alanine has been researched along with fluorouracil in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (41.38) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, BM; Meanwell, NA; Shu, YZ; Zhuo, X | 1 |
| Akiyoshi, H; Fujii, S; Minato, Y; Okuda, H; Toide, H | 1 |
| Furusawa, M; Hara, Y; Kono, A | 1 |
| Barnes, S; Diasio, RB; Sweeny, DJ | 1 |
| Barnes, S; Diasio, RB; Heggie, GD; Sweeny, DJ | 1 |
| Bisaillon, JG; De Repentigny, J; Mathieu, LG | 1 |
| Kensler, CJ; Swiniarski, J; Venditti, JM; Wodinsky, I | 1 |
| Gray, PN; Rachmeller, M | 1 |
| Pine, MJ | 1 |
| Koenig, H; Patel, A | 1 |
| Powis, G | 1 |
| Almond, MR; Chestnut, WG; Harrington, JA; Porter, DJ; Spector, T; Tanoury, G | 1 |
| Imaoka, T; Kawaguchi, T; Kishi, K; Kiyono, K; Kubo, M; Tatsumi, K; Yamauchi, T; Yanagihara, Y | 1 |
| Fujimoto, S; Kaneko, M; Kikugawa, M; Kontani, Y; Tamaki, N | 1 |
| Harada, M; Kimura, A; Koga, K; Miura, I; Nishitani, H | 1 |
| GARRETT, AJ; ROGERS, HJ | 1 |
| Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z | 1 |
| Furuhata, T; Hata, F; Hirata, K; Katsuramaki, T; Kawakami, M; Kihara, C; Kimura, Y; Ohmura, T; Okita, K; Sasaki, K; Tsuruma, T; Yamaguchi, K | 1 |
| Benz, C; Cadman, E; Heimer, R; O'Shaughnessy, J | 1 |
| Furuta, R; Hibi, S; Ina, K; Kabeya, M; Kataoka, T; Kato, T; Kawai, M; Kayukawa, S; Kikuchi, F; Minagawa, Y; Tajiri, C; Yuasa, S | 1 |
| Do, H; Hong, S; Jung, Y; Kim, H; Kim, YM; Kong, H; Lee, Y; Yoon, JH | 1 |
| Adamski, J; Halama, A; Hrabě de Angelis, M; Möller, G; Riesen, N | 1 |
| Jensen, BV; Larsen, FO; Nielsen, DL; Palshof, JA; Pfeiffer, P | 1 |
| Abe, M; Bamba, N; Enami, A; Makihara, K; Masaoka, M; Masuda, N; Mizutani, M; Shikata, A; Takada, S; Yamamoto, M; Yamamura, J; Yasojima, H | 1 |
| Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA | 1 |
| Asano, RT; Fujimoto, SI; Imano, M; Itoh, T; Matsuda, T; Nishida, S; Satou, T; Takeda, T; Tsubaki, M | 1 |
| Kamiki, Y; Makino, K; Takeuchi, I | 1 |
| Ahmad, SI | 1 |
| Jiang, Y | 1 |
2 review(s) available for alanine and fluorouracil
| Article | Year |
|---|---|
Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man.
Topics: Alanine; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Ifosfamide; Kinetics; Methotrexate; Thymidine | 1983 |
A systematic review of salvage therapy to patients with metastatic colorectal cancer previously treated with fluorouracil, oxaliplatin and irinotecan +/- targeted therapy.
Topics: Alanine; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colorectal Neoplasms; Databases, Factual; ErbB Receptors; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Molecular Targeted Therapy; Organoplatinum Compounds; Oxaliplatin; Phenylurea Compounds; PubMed; Pyridines; Retreatment; Salvage Therapy; Treatment Failure; Triazines | 2014 |
1 trial(s) available for alanine and fluorouracil
| Article | Year |
|---|---|
[Pilot study on clinical effects of rebamipide gargle against oral mucositis induced by fluoropyrimidines].
Topics: Alanine; Antimetabolites, Antineoplastic; Colonic Neoplasms; Fluorouracil; Humans; Mouthwashes; Pilot Projects; Prospective Studies; Quinolones; Stomach Neoplasms; Stomatitis | 2011 |
26 other study(ies) available for alanine and fluorouracil
| Article | Year |
|---|---|
Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.
Topics: Drug Design; Fluorine; Halogenation; Humans; Pharmaceutical Preparations | 2020 |
Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Alanine; Animals; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; NADP; Neoplasms, Experimental; Nucleic Acid Precursors; Rats; Tegafur; Tissue Distribution | 1977 |
[Effect of uracil on the both reactions, 5-fluorouracil degradation into 2-fluoro-beta-alanine and 5-fluorouracil splitting from tegafur in human tumor].
Topics: Adenocarcinoma, Papillary; Alanine; beta-Alanine; Fluorouracil; Humans; Lung Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil | 1989 |
Formation of conjugates of 2-fluoro-beta-alanine and bile acids during the metabolism of 5-fluorouracil and 5-fluoro-2-deoxyuridine in the isolated perfused rat liver.
Topics: Alanine; Animals; beta-Alanine; Bile; Bile Acids and Salts; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Liver; Male; Perfusion; Rats | 1988 |
Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation.
Topics: Alanine; beta-Alanine; Bile Acids and Salts; Cholic Acids; Chromatography, High Pressure Liquid; Fluorouracil; Humans; Mass Spectrometry; Pancreatic Neoplasms | 1987 |
Influence of cell wall inhibitors in thymine-requiring Staphylococcus aureus strains.
Topics: Alanine; Cell Wall; Cycloserine; DNA, Bacterial; Fluorouracil; Methicillin; Mucoproteins; Penicillin Resistance; Penicillins; Staphylococcus; Thymine | 1972 |
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mechlorethamine; Methotrexate; Mice; Neoplasm Transplantation; Prednisone; Procarbazine; Prognosis; Radioisotope Teletherapy; Radiotherapy Dosage; Transplantation, Homologous; Vinblastine; Vincristine | 1974 |
The effect of 5-fluorouracil and 6-thioguanine incorporation on the amino acid acceptor activity of Escherichia coli tRNA.
Topics: Alanine; Amino Acids; Carbon Isotopes; Centrifugation, Density Gradient; Escherichia coli; Fluorouracil; Glutamates; Leucine; Lysine; Methionine; Phenylalanine; RNA, Bacterial; RNA, Transfer; Thioguanine; Tyrosine; Valine | 1967 |
Response of intracellular proteolysis to alteration of bacterial protein and the implications in metabolic regulation.
Topics: Alanine; Bacillus subtilis; Bacterial Proteins; Canavanine; Carbon Isotopes; Chloramphenicol; Dactinomycin; Escherichia coli; Fluorouracil; Leucine; Phenylalanine; Puromycin; Temperature; Ultraviolet Rays | 1967 |
The acute cerebellar syndrome in 5-fluorouracil chemotherapy: a manifestation of fluoroacetate intoxication.
Topics: Alanine; Animals; Brain Chemistry; Cats; Cerebellar Ataxia; Citrates; Citric Acid Cycle; Fluoroacetates; Fluorouracil; Kidney; Liver; Seizures | 1970 |
Enzymatic elimination of fluoride from alpha-fluoro-beta-alanine.
Topics: Alanine; Alanine Transaminase; Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; beta-Alanine; Catalysis; Chemical Phenomena; Chemistry, Physical; Enzyme Activation; Enzyme Inhibitors; Fluorides; Fluorouracil; Glyoxylates; Kinetics; Liver; Malondialdehyde; Molecular Sequence Data; Rats; Stereoisomerism; Substrate Specificity; Transaminases | 1995 |
3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase.
Topics: Alanine; Animals; Antineoplastic Agents; Dihydrouracil Dehydrogenase (NAD+); Drug Synergism; Fluorouracil; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Pyridines; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Tumor Cells, Cultured; Uracil | 1993 |
Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine-glyoxylate aminotransferase 2.
Topics: Alanine; Alanine Transaminase; Animals; beta-Alanine; Fluorouracil; Kinetics; Liver; Precipitin Tests; Rats; Transaminases; Uracil | 1993 |
Comparative studies on the metabolism of new fluorinated pyrimidine drugs in the liver by in vivo 19F magnetic resonance spectroscopic observation.
Topics: Alanine; Animals; Dihydrouracil Dehydrogenase (NAD+); Drug Interactions; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyridines; Rats; Rats, Wistar; Tegafur; Uracil | 1993 |
THE INTERRELATIONSHIP BETWEEN MUCOPEPTIDE AND RIBITOL TEICHOIC ACID FORMATION AS SHOWN BY THE EFFECT OF INHIBITORS.
Topics: Alanine; Carbohydrate Metabolism; Cell Physiological Phenomena; Cell Wall; Chemistry Techniques, Analytical; Cycloserine; Dextrans; Fluorouracil; Glucosamine; Glycine; Lysine; Mucoproteins; Penicillin G; Pentosephosphates; Peptides; Pharmacology; Research; Ribitol; Staphylococcus; Staphylococcus aureus; Teichoic Acids | 1965 |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cytosine; DNA Probes; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype; Humans; Leucovorin; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Polymorphism, Genetic; Random Allocation; Thymidylate Synthase; Thymine; Transfection; Transplantation, Heterologous; Valine | 2004 |
Plasma level of a 5-fluorouracil metabolite, fluoro-beta-alanine correlates with dihydropyrimidine dehydrogenase activity of peripheral blood mononuclear cells in 5-fluorouracil treated patients.
Topics: Aged; Alanine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Combined Modality Therapy; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Leukocytes, Mononuclear; Male; Middle Aged; o-Phthalaldehyde | 2006 |
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity.
Topics: Alanine; Animals; Azaserine; Cell Line, Tumor; Cell Survival; Diazooxonorleucine; Dose-Response Relationship, Drug; Fluorouracil; Methotrexate; Nucleic Acid Synthesis Inhibitors; Purines; Thioinosine; Thionucleotides; Uracil Nucleotides | 1981 |
Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site.
Topics: Alanine; Amino Acids, Aromatic; Animals; Antimetabolites, Antineoplastic; Cecum; Colon; Delayed-Action Preparations; Fluorouracil; Gastrointestinal Contents; Hydrogen-Ion Concentration; Male; Molecular Targeted Therapy; Prodrugs; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2011 |
Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine.
Topics: Alanine; Amino Acids; Apoptosis; Biomarkers; Carnitine; Caspase 3; Caspase 7; Cell Line, Tumor; Etoposide; Flow Injection Analysis; Fluorouracil; Glutamic Acid; HEK293 Cells; Hep G2 Cells; Humans; Metabolomics; Precision Medicine | 2013 |
[Therapeutic effect of rebamipide for oral mucositis associated with FEC therapy for breast cancer].
Topics: Adult; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Middle Aged; Quinolones; Stomatitis | 2014 |
Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model.
Topics: Alanine; Animals; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Apoptosis; Disease Models, Animal; Fluorouracil; Glutathione; Intestine, Small; Macrophages; Male; Mice, Inbred BALB C; Mucositis; Nitric Oxide Synthase Type II; Quinolones; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2015 |
Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
Topics: Alanine; Animals; Antimetabolites; Antioxidants; Cell Death; Cell Survival; Fluorouracil; Gene Expression Regulation; Humans; Keratinocytes; Mucositis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinolones; TOR Serine-Threonine Kinases | 2018 |
Therapeutic efficacy of rebamipide-loaded PLGA nanoparticles coated with chitosan in a mouse model for oral mucositis induced by cancer chemotherapy.
Topics: Alanine; Animals; Anti-Ulcer Agents; Chitosan; Coated Materials, Biocompatible; Drug Liberation; Fluorouracil; Lactic Acid; Male; Mice, Inbred ICR; Microscopy, Electron, Scanning; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinolones; Stomatitis; Treatment Outcome | 2018 |
5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Deoxyribonucleosides; Deoxyribose; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Inflammation; Models, Theoretical; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Study the nature of interaction between 5-Fluorouracil anti-cancer drug and borospherene.
Topics: Alanine; Amino Acids; Antineoplastic Agents; Drug Delivery Systems; Fluorouracil | 2022 |