alanine and eglumetad

alanine has been researched along with eglumetad in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (87.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bueno, AB; Catlow, J; Clay, MP; Coffey, DS; Collado, I; Dantzig, AH; de Dios, A; Domínguez, C; Herin, MF; Jiang, H; Lindstrom, T; Martín, JA; Martín, LM; Martínez-Grau, MA; Monn, JA; Montero, C; Pedregal, C; Schoepp, DD; Stratford, RE; Tabas, LB; Tizzano, JP; Wright, RA	1
Danysz, W	1
Hart, JC; Johnson, BG; Knitowski, KM; McKinzie, DL; Perkins, EJ; Rorick-Kehn, LM; Schoepp, DD	1
Li, W; Neugebauer, V	1
Abraham, T; Perkins, EJ	1
Dunayevich, E; Erickson, J; Landbloom, R; Levine, L; Schoepp, DD; Tollefson, GD	1
Eriksson, AH; Pak, YA; Perkins, EJ; Sawada, G; Varma, MV; Zimmerman, CL	1
Eriksson, AH; Perkins, EJ; Varma, MV; Zimmerman, CL	1

Reviews

1 review(s) available for alanine and eglumetad

Article	Year
LY-544344. Eli Lilly. IDrugs : the investigational drugs journal, 2005, Volume: 8, Issue:9 Topics: Alanine; Animals; Anti-Anxiety Agents; Anxiety; Bridged Bicyclo Compounds; Clinical Trials as Topic; Humans; Prodrugs; Receptors, Metabotropic Glutamate; Structure-Activity Relationship	2005

Trials

1 trial(s) available for alanine and eglumetad

Article	Year
Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:7 Topics: Adult; Alanine; Analysis of Variance; Anxiety Disorders; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Treatment Outcome	2008

Article

Year

Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:7

Topics: Adult; Alanine; Analysis of Variance; Anxiety Disorders; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Treatment Outcome

2008

Other Studies

6 other study(ies) available for alanine and eglumetad

Article	Year
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist. Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16 Topics: Administration, Oral; Alanine; Animals; Anti-Anxiety Agents; Biological Availability; Bridged Bicyclo Compounds; Cell Line, Tumor; Cricetinae; Cricetulus; Dipeptides; Humans; Male; Peptide Transporter 1; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex, Startle; Stereoisomerism; Structure-Activity Relationship; Symporters	2005
Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:2 Topics: Administration, Oral; Alanine; Animals; Behavior, Animal; Biological Availability; Body Temperature; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Motor Activity; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stress, Physiological; Time Factors	2006
Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain. Journal of neurophysiology, 2006, Volume: 96, Issue:4 Topics: Alanine; Aminobutyrates; Amygdala; Animals; Arthritis; Bridged Bicyclo Compounds; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamates; Male; Neuronal Plasticity; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission	2006
Pharmacokinetics, metabolism, and excretion of the intestinal peptide transporter 1 (SLC15A1)-targeted prodrug (1S,2S,5R,6S)-2-[(2'S)-(2-amino)propionyl]aminobicyclo[3.1.0.]hexen-2,6-dicarboxylic acid (LY544344) in rats and dogs: assessment of first-pass Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:10 Topics: Alanine; Animals; Biotransformation; Bridged Bicyclo Compounds; Dogs; Dose-Response Relationship, Drug; Feces; Female; Hydrolysis; Male; Peptide Transporter 1; Prodrugs; Rats; Rats, Inbred F344; Symporters	2007
Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxy Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:1 Topics: Alanine; Animals; Biological Availability; Bridged Bicyclo Compounds; Caco-2 Cells; Cell Line; Chromatography, High Pressure Liquid; Dogs; Excitatory Amino Acid Agonists; Humans; Intestinal Absorption; Tandem Mass Spectrometry	2009
The intestinal absorption of a prodrug of the mGlu2/3 receptor agonist LY354740 is mediated by PEPT1: in situ rat intestinal perfusion studies. Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:3 Topics: Alanine; Animals; Bridged Bicyclo Compounds; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Intestinal Absorption; Male; Peptide Transporter 1; Prodrugs; Rats; Rats, Inbred F344; Symporters	2010