alanine has been researched along with dinitrobenzenes in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (22.92) | 18.7374 |
| 1990's | 7 (14.58) | 18.2507 |
| 2000's | 14 (29.17) | 29.6817 |
| 2010's | 14 (29.17) | 24.3611 |
| 2020's | 2 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Campos-Neto, A; Levine, H; Schlossman, SF; Yanovski, A; Yaron, A | 1 |
| Imm, A; Meyer-Delius, M; Rüde, E; Stötter, H | 1 |
| Lai, CH; Maurer, PH; Shevach, EM | 1 |
| Adamson, JG; Crivici, A; Hoang, T; Lajoie, GA | 1 |
| Lübbe, D; Schwartze, G | 1 |
| Blanc, T; Leopold, EJ; Tran, AD | 1 |
| Christen, P; Kochhar, S | 1 |
| Hudecz, F; Mezö, G; Szókán, G | 1 |
| Aberhart, DJ; Cotting, JA; Lin, HJ | 1 |
| Abadie, A; Löwy, I; Prouvost-Danon, A; Thèze, J | 1 |
| Goodman, JW; Kindler, H; Nitecki, DE; Scott, D | 1 |
| Licht, A; Pecht, I; Zidovetzki, R | 1 |
| Chedid, L; Lowy, I; Theze, J | 1 |
| Abuaf, PA; Corkum, N; Crowther, JB; Goldstein, G; Goodlett, DR; Kowalski, KA; Mukherjee, TK; Savage, PA; Tolan, JW | 1 |
| Goodnough, DB; Lutz, MP; Wood, PL | 1 |
| Cantacuzène, D; Harth-Fritschy, E | 1 |
| Armstrong, DW; Gaucher, A; Mazaleyrat, JP; Péter, A; Török, G; Wakselman, M | 1 |
| Christen, P; Kochhar, S; Mouratou, B | 1 |
| Hess, S; Pannell, LK; van Beek, J | 1 |
| Biddison, WE; Damirjian, M; Gagnon, SJ; Turner, R; Wang, Z | 1 |
| FITTKAU, S | 1 |
| Czerwenka, C; Kählig, H; Lindner, W; Lipkowitz, KB; Maier, NM; Zhang, MM | 1 |
| Bhushan, R; Brückner, H | 2 |
| Berlinck, RG; de Oliveira, MF; König, GM; Molinski, TF; Rogers, EW | 1 |
| Ackermann, BL; Berna, MJ | 1 |
| Downey, B; Ngim, KK; Zynger, J | 1 |
| Bhushan, R; Brückner, H; Kumar, V | 1 |
| Kikuchi, Y; Shinoda, J | 1 |
| Bhushan, R; Kumar, V | 1 |
| Bhushan, R; Kumar, V; Tanwar, S | 1 |
| Bhushan, R; Kumar, R | 1 |
| Bhushan, R; Tanwar, S | 1 |
| Gutheil, WG; Jamindar, D | 1 |
| Bhushan, R; Dixit, S; Tanwar, S | 1 |
| Bhushan, R; Dubey, R | 1 |
| Julínek, O; Lindner, W; Urbanová, M | 1 |
| Hess, S | 2 |
| Concheiro, M; Huestis, MA; Newmeyer, MN | 1 |
| Bhushan, R; Vashistha, VK | 1 |
| Capon, RJ; Fremlin, LJ; Khalil, Z; Prasad, P; Ratnayake, R; Salim, AA; Vijayasarathy, S | 1 |
| Alexander, A; Jones, J; Jones, M; Negrusz, A; Shu, I | 1 |
| Borg, D; Kolb, E; Lantigua, C; Stripp, R | 1 |
| Ahmadi, SH; Tabar Heydar, K; Yaghoubnejad, S; Zadmard, R | 1 |
| Ayon, NJ; Gutheil, WG; Sharma, AD | 1 |
| Bhushan, R; Martens, J; Sethi, S | 1 |
| Badepally, NG; Singh, A; Surolia, A | 1 |
3 review(s) available for alanine and dinitrobenzenes
| Article | Year |
|---|---|
Marfey's reagent for chiral amino acid analysis: a review.
Topics: Alanine; Amines; Amino Acids; Animals; Bacteria; Biochemistry; Body Fluids; Cysteine; Dinitrobenzenes; Humans; Peptides; Stereoisomerism | 2004 |
Use of Marfey's reagent and analogs for chiral amino acid analysis: assessment and applications to natural products and biological systems.
Topics: Alanine; Amino Acids; Animals; Biological Products; Dinitrobenzenes; Humans; Peptides; Stereoisomerism | 2011 |
Assessment and application of Marfey's reagent and analogs in enantioseparation: a decade's perspective.
Topics: Alanine; Amino Acids; Animals; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dinitrobenzenes; Humans; Hydrophobic and Hydrophilic Interactions; Stereoisomerism | 2021 |
45 other study(ies) available for alanine and dinitrobenzenes
| Article | Year |
|---|---|
Specificity and genetic restrictions of the guinea-pig immune response to dinitrophenyl-lysyl-alanyl octapeptides.
Topics: Alanine; Animals; Antibody Formation; Antibody Specificity; Dinitrobenzenes; Female; Genes, MHC Class II; Guinea Pigs; Immunity, Cellular; Isoelectric Focusing; Lysine; Male; Nitrobenzenes; Oligopeptides; T-Lymphocytes | 1978 |
Specificity of H-2-linked Ir gene control in mice: recognition of the core structure A--L in defined sequence analogues of (T,G,)-A--L.
Topics: Alanine; Animals; Antibodies; Cell Separation; Cross Reactions; Dinitrobenzenes; Female; Genes, MHC Class II; H-2 Antigens; Immune Sera; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Oligopeptides; Peptides; Spleen; T-Lymphocytes | 1979 |
Immune responses of outbred guinea pigs to the sequential polymer poly(L-Tyr-L-Glu-L-Ala-Gly): association of response to strain 13 histocompatibility locus.
Topics: Alanine; Animals; Antibody Formation; Dinitrobenzenes; Dose-Response Relationship, Immunologic; Genes; Glutamates; Glycine; Guinea Pigs; Histocompatibility; Immune Sera; Isoantibodies; Peptides; Serum Albumin, Bovine; Skin Tests; Tyrosine | 1977 |
Use of Marfey's reagent to quantitate racemization upon anchoring of amino acids to solid supports for peptide synthesis.
Topics: Alanine; Amino Acids; Chromatography, High Pressure Liquid; Dinitrobenzenes; Indicators and Reagents; Peptides; Stereoisomerism | 1992 |
[Effect of structure of hapten carrying model substances on contact reaction: DNP conjugates of stereoisomers of alpha-alanine following DNCB sensitization].
Topics: Alanine; Dermatitis, Contact; Dinitrobenzenes; Dinitrochlorobenzene; Female; Haptens; Humans; Male; Patch Tests; Structure-Activity Relationship | 1990 |
Free solution capillary electrophoresis and micellar electrokinetic resolution of amino acid enantiomers and peptide isomers with L- and D-Marfey's reagents.
Topics: Alanine; Amino Acids; Dinitrobenzenes; Electrophoresis; Isomerism; Kinetics; Micelles; Peptides | 1990 |
Amino acid analysis by high-performance liquid chromatography after derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide.
Topics: Alanine; Amino Acids; Aspartate Aminotransferases; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dinitrobenzenes; Fructose-Bisphosphate Aldolase; Muramidase; Nitrobenzenes | 1989 |
Application of Marfey's reagent in racemization studies of amino acids and peptides.
Topics: Alanine; Amino Acids; Chromatography, High Pressure Liquid; Dinitrobenzenes; Hydrolysis; Leucine; Nitrobenzenes; Peptides; Stereoisomerism | 1988 |
Separation by high-performance liquid chromatography of (3R)- and (3S)-beta-leucine as diastereomeric derivatives.
Topics: Alanine; Amino Acid Isomerases; Chromatography, High Pressure Liquid; Dinitrobenzenes; Intramolecular Transferases; Leucine; Stereoisomerism | 1985 |
Fine specificity and idiotype analysis of the IgE response to the synthetic terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) and its dinitrophenyl conjugate (DNP-GAT).
Topics: Alanine; Animals; Antibody Specificity; Biopolymers; Cross Reactions; Cytoplasmic Granules; Dinitrobenzenes; Epitopes; Female; Glutamates; Immunoglobulin E; Immunoglobulin G; Immunoglobulin Idiotypes; Male; Mast Cells; Mice; Mice, Inbred Strains; Tyrosine | 1980 |
Immunogenicity of biotinylated hapten-avidin complexes.
Topics: Alanine; Aminocaproates; Animals; Antibody Formation; Avidin; Binding, Competitive; Biotin; Dinitrobenzenes; Enzyme-Linked Immunosorbent Assay; Female; Haptens; Immunoglobulin G; Lysine; Macromolecular Substances; Male; Mice; Mice, Inbred Strains; Ovalbumin; Peptides | 1984 |
Positive cooperativity in the hapten binding by the VL dimer of protein 315.
Topics: 4-Chloro-7-nitrobenzofurazan; Alanine; Animals; Dinitrobenzenes; Haptens; Immunoglobulin A; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Lysine; Mice; Mice, Inbred BALB C; Models, Biological; Myeloma Proteins; Protein Binding; Protein Conformation; Spectrophotometry; Thermodynamics | 1981 |
Stimulation of the in vivo dinitrophenyl antibody response to the DNP conjugate of L-glutamic acid60-L-alanine30-L-Tyrosine10 (GAT) polymer by a synthetic adjuvant, muramyl dipeptide (MDP): target cells for adjuvant activity and isotypic pattern of MDP-st
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Alanine; Animals; Antibody Formation; B-Lymphocytes; Dinitrobenzenes; Female; Glutamates; Glycopeptides; Immunization, Passive; Immunologic Memory; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Mice, Inbred DBA; Nitrobenzenes; Ovalbumin; Pertussis Vaccine; Polymers; T-Lymphocytes; Tyrosine | 1980 |
Peptide chiral purity determination: hydrolysis in deuterated acid, derivatization with Marfey's reagent and analysis using high-performance liquid chromatography-electrospray ionization-mass spectrometry.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Deuterium; Dinitrobenzenes; Hydrolysis; Indicators and Reagents; Mass Spectrometry; Molecular Sequence Data; Peptides; Protein Conformation | 1995 |
Separation and quantification of D- and L-phosphoserine in rat brain using N alpha-(2,4-dinitro-5-fluorophenyl)-L-alaninamide (Marfey's reagent) by high-performance liquid chromatography with ultraviolet detection.
Topics: Alanine; Animals; Brain Chemistry; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dinitrobenzenes; Hippocampus; Indicators and Reagents; Male; Phosphoserine; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Stereoisomerism | 1995 |
Esterification of 9-fluorenylmethoxycarbonyl-glycosylated serine and cysteine derivatives with an hydroxymethyl resin.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Cysteine; Dinitrobenzenes; Esterification; Fluorenes; Glycosylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Peptides; Resins, Plant; Serine; Stereoisomerism; Triazines | 1997 |
High-performance liquid chromatographic separation of novel atropic alpha,alpha-disubstituted-beta-amino acids, either on different beta-cyclodextrin-bonded phases or as their 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide derivatives.
Topics: Alanine; Amino Acids; Chromatography, High Pressure Liquid; Dinitrobenzenes; Hydrogen-Ion Concentration; Indicators and Reagents; Stereoisomerism | 1999 |
Amino acid analysis by high-performance liquid chromatography after derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (Marfey's reagent).
Topics: Alanine; Amino Acids; Chromatography, High Pressure Liquid; Dinitrobenzenes; Hydrolysis; Indicators and Reagents | 2000 |
Acid hydrolysis of silk fibroins and determination of the enrichment of isotopically labeled amino acids using precolumn derivatization and high-performance liquid chromatography-electrospray ionization-mass spectrometry.
Topics: Acetic Acid; Alanine; Amino Acids; Animals; Bombyx; Calibration; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Diet; Dinitrobenzenes; Exocrine Glands; Fibroins; Hydrolysis; Insect Proteins; Larva; Nitrogen Radioisotopes; Silk; Software; Spectrometry, Mass, Electrospray Ionization; Spiders | 2002 |
MHC recognition by hapten-specific HLA-A2-restricted CD8+ CTL.
Topics: Alanine; Amino Acid Substitution; Antigen Presentation; Asparagine; Cell Line; Cell Membrane; Cells, Cultured; Cytotoxicity, Immunologic; Dinitrobenzenes; Epitopes, T-Lymphocyte; Haptens; HLA-A Antigens; HLA-A2 Antigen; Humans; Lysine; Peptide Fragments; Protein Binding; T-Lymphocytes, Cytotoxic; Transfection | 2003 |
[SEPARATION OF 2,4-DINITROPHENYL-AMINOACIDS BY HIGH-VOLTAGE PAPER ELECTROPHORESIS].
Topics: Acetates; Alanine; Amino Acids; Buffers; Dinitrobenzenes; Dinitrophenols; Electrophoresis; Electrophoresis, Paper; Hydrogen-Ion Concentration; Paper; Pyridines; Research | 1965 |
Chiral recognition of peptide enantiomers by cinchona alkaloid derived chiral selectors: mechanistic investigations by liquid chromatography, NMR spectroscopy, and molecular modeling.
Topics: Alanine; Carbamates; Chromatography, Liquid; Cinchona Alkaloids; Dinitrobenzenes; Magnetic Resonance Spectroscopy; Models, Molecular; Oligopeptides; Peptides; Stereoisomerism; Thermodynamics | 2003 |
Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey's analysis.
Topics: Alanine; Animals; Australia; Brazil; Dinitrobenzenes; Florida; Isoxazoles; Mixed Function Oxygenases; Molecular Structure; Porifera; Stereoisomerism; Tyrosine | 2005 |
Quantification of serine enantiomers in rat brain microdialysate using Marfey's reagent and LC/MS/MS.
Topics: Alanine; Animals; Brain; Chromatography, High Pressure Liquid; Dinitrobenzenes; Microdialysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Serine; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2007 |
Analysis of monoethanolamine by derivatization with Marfey's reagent and HPLC.
Topics: Alanine; Chromatography, High Pressure Liquid; Dinitrobenzenes; Drug Stability; Ethanolamine; Reproducibility of Results; Sensitivity and Specificity | 2007 |
Indirect resolution of enantiomers of penicillamine by TLC and HPLC using Marfey's reagent and its variants.
Topics: Alanine; Antirheumatic Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dinitrobenzenes; Molecular Structure; Penicillamine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stereoisomerism | 2007 |
Rod1, an arrestin-related protein, is phosphorylated by Snf1-kinase in Saccharomyces cerevisiae.
Topics: Alanine; Amino Acid Substitution; AMP-Activated Protein Kinases; Arrestin; Carrier Proteins; Dinitrobenzenes; Drug Resistance, Fungal; Fungal Proteins; Gene Expression Regulation, Fungal; Membrane Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Transcription Factors | 2007 |
Indirect resolution of baclofen enantiomers from pharmaceutical dosage form by reversed-phase liquid chromatography after derivatization with Marfey's reagent and its structural variants.
Topics: Alanine; Baclofen; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dinitrobenzenes; Dosage Forms; GABA Agonists; Reference Standards; Reproducibility of Results; Stereoisomerism | 2008 |
Chromatographic separation of enantiomers of non-protein alpha-amino acids after derivatization with Marfey's reagent and its four variants.
Topics: Alanine; Amino Acids; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dinitrobenzenes; Sensitivity and Specificity; Trifluoroacetic Acid | 2009 |
Reversed-phase high performance liquid chromatographic separation of diastereomers of beta-amino alcohols and microwave assisted synthesis of Marfey's reagent, its chiral variants and diastereomers.
Topics: Alanine; Amino Alcohols; Chromatography, High Pressure Liquid; Dinitrobenzenes; Hydrophobic and Hydrophilic Interactions; Linear Models; Microwaves; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2009 |
Reversed-phase liquid chromatographic determination of enantiomers of atenolol in rat plasma using derivatization with Marfey's reagent.
Topics: Alanine; Animals; Atenolol; Chromatography, High Pressure Liquid; Dinitrobenzenes; Drug Stability; Linear Models; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2009 |
A liquid chromatography-tandem mass spectrometry assay for Marfey's derivatives of L-Ala, D-Ala, and D-Ala-D-Ala: application to the in vivo confirmation of alanine racemase as the target of cycloserine in Escherichia coli.
Topics: Alanine; Alanine Racemase; Biological Assay; Cell Wall; Chromatography, Liquid; Cycloserine; Dinitrobenzenes; Dipeptides; Escherichia coli; Reference Standards; Reproducibility of Results; Substrate Specificity; Tandem Mass Spectrometry | 2010 |
Indirect enantioresolution of (R,S)-mexiletine by reversed-phase high-performance liquid chromatography via diastereomerization with [(S,S)-O,O'-di-p-toluoyl tartaric acid anhydride], (S)-naproxen and nine chiral reagents synthesized as variants of Marfey
Topics: Alanine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dinitrobenzenes; Mexiletine; Naproxen; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tartrates | 2011 |
Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R,S)-Cinacalcet.
Topics: Alanine; Arginine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Chromatography, Thin Layer; Cinacalcet; Dinitrobenzenes; Histidine; Hydrogen-Ion Concentration; Linear Models; Naphthalenes; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Temperature | 2011 |
Study of stereoselective interactions of carbamoylated quinine and quinidine with 3,5-dinitrobenzoyl α-amino acids using VCD spectroscopy in the region of C−H stretching vibrations.
Topics: Absorption; Alanine; Amino Acids; Circular Dichroism; Dinitrobenzenes; Glycine; Hydrophobic and Hydrophilic Interactions; Isoleucine; Leucine; Quinidine; Quinine; Stereoisomerism; Valine; Vibration | 2011 |
A universal HPLC-MS method to determine the stereochemistry of common and unusual amino acids.
Topics: Alanine; Amino Acids; Chromatography, High Pressure Liquid; Dinitrobenzenes; Hydrolysis; Isothiocyanates; Mass Spectrometry; Peptides; Proteins; Reference Standards; Statistics as Topic; Stereoisomerism | 2012 |
Rapid quantitative chiral amphetamines liquid chromatography-tandem mass spectrometry: method in plasma and oral fluid with a cost-effective chiral derivatizing reagent.
Topics: Adult; Alanine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dinitrobenzenes; Humans; Limit of Detection; Male; Methamphetamine; Reference Standards; Saliva; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tandem Mass Spectrometry | 2014 |
Synthesis of variants of Marfey's reagent having d-amino acids as chiral auxiliaries and liquid-chromatographic enantioseparation of (RS)-Mexiletine in spiked plasma: assessment and comparison with L-amino acid analogs.
Topics: Alanine; Amides; Amino Acids; Blood Chemical Analysis; Chromatography, Liquid; Dinitrobenzenes; Humans; Indicators and Reagents; Mexiletine; Microwaves; Sensitivity and Specificity; Stereoisomerism | 2015 |
C3 and 2D C3 Marfey's Methods for Amino Acid Analysis in Natural Products.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Biological Products; Dinitrobenzenes; Molecular Structure; Stereoisomerism | 2016 |
Determination of methamphetamine enantiomer composition in human hair by non-chiral liquid chromatography-tandem mass spectrometry method.
Topics: Alanine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dinitrobenzenes; Hair; Humans; Limit of Detection; Methamphetamine; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Substance Abuse Detection; Tandem Mass Spectrometry | 2016 |
Chiral Analysis of Methamphetamine in Oral Fluid Samples: A Method to Distinguish Licit from Illicit Drug Use.
Topics: Alanine; Amphetamine-Related Disorders; Calibration; Central Nervous System Stimulants; Chromatography, Reverse-Phase; Dinitrobenzenes; Drug Monitoring; Humans; Isomerism; Linear Models; Methamphetamine; Reference Standards; Reproducibility of Results; Saliva; Solid Phase Extraction; Structure-Activity Relationship; Substance Abuse Detection; Tandem Mass Spectrometry | 2018 |
Preparation and evaluation of a chiral HPLC stationary phase based on cone calix[4]arene functionalized at the upper rim with l-alanine units.
Topics: Alanine; Calixarenes; Chromatography, High Pressure Liquid; Dinitrobenzenes; Models, Chemical; Pharmaceutical Preparations; Phenols; Stereoisomerism | 2018 |
LC-MS/MS-Based Separation and Quantification of Marfey's Reagent Derivatized Proteinogenic Amino Acid DL-Stereoisomers.
Topics: Alanine; Amino Acids; Chromatography, Liquid; Dinitrobenzenes; Glycine; Hydrogen-Ion Concentration; Kinetics; Methicillin-Resistant Staphylococcus aureus; Sensitivity and Specificity; Solvents; Stereoisomerism; Tandem Mass Spectrometry | 2019 |
A Universal HPLC-MS Method to Determine the Stereochemistry of Common and Unusual Amino Acids.
Topics: Alanine; Amino Acids; Buffers; Chromatography, High Pressure Liquid; Dinitrobenzenes; Hydrolysis; Isothiocyanates; Mass Spectrometry; Nitro Compounds; Peptides; Stereoisomerism | 2019 |
Role of a cysteine residue in substrate entry and catalysis in MtHIBADH: Analysis by chemical modifications and site-directed mutagenesis.
Topics: Alanine; Alcohol Oxidoreductases; Bacterial Proteins; Catalysis; Cysteine; Dinitrobenzenes; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; p-Chloromercuribenzoic Acid; Protein Conformation; Recombinant Proteins; Serine; Structure-Activity Relationship; Substrate Specificity | 2021 |