alanine has been researched along with dichloroacetic acid in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (58.06) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeVivo, DC; Haymond, MW; Nelson, JS; Obert, KA; Pagliara, AS | 1 |
| Baverel, G; Brière, R; Gougoux, A; Lemieux, G; Vinay, P | 1 |
| Kornhauser, DM; Moore, GW; Stacpoole, PW | 1 |
| Aoki, TT; Goodman, MN; Ruderman, NB | 1 |
| Herndon, DN; Jahoor, F; Miyoshi, H; Wolfe, RR | 1 |
| Hammen, HW; Radeck, W; Schadewaldt, P; Staib, W | 1 |
| Placko, R; Siegel, JH; Vary, TC | 1 |
| Favier, RJ; Flandrois, R; Koubi, HE; Mayet, MH; Semporé, B; Simi, B | 1 |
| Harding, GB; Thompson, LC; Ward, RA; Wathen, RL | 1 |
| Cherrington, AD; Diamond, MP; Lacy, WW; Suhrer, JH; Williams, PE | 1 |
| Caldecourt, MA; Palmer, TN; Sugden, MC | 1 |
| Hems, R | 2 |
| Duff, DA; Snell, K | 1 |
| Aynsley-Green, A; Jenkins, PA; Soltész, G; Weindling, AM | 1 |
| Baumgartner, TG; Curry, SH; Harman, EM; Misbin, RI; Stacpoole, PW | 1 |
| Cherrington, AD; Diamond, MP; Erlendson, L; Lacy, WW; Rabin, D; Rollings, RC; Williams, PE | 1 |
| Cherrington, AD; Diamond, MP; Lacy, WW; Williams, PE | 1 |
| Moore, GW; Oates, JA; Rabin, D; Stacpoole, PW; Wells, PG; Wilkinson, GR | 1 |
| Arnold, DL; De Stefano, N; Ford, B; Genge, A; Karpati, G; Matthews, PM | 1 |
| Frazer, E; Jahoor, F; Zhang, XJ | 1 |
| Brown, J; Gore, DC; Lee, R | 1 |
| Brown, JA; Gore, DC | 1 |
| Dickson, AJ; Murray, K | 1 |
| Adam, R; Dimicoli, JL; Patry, J | 1 |
| Brocks, C; Chatham, JC; Lloyd, S | 1 |
| Giraud, G; Karolin, J; Wynne, K | 1 |
| Adam, R; Blouquit, Y; Dimicoli, JL; Nedelec, JF; Patry, J | 1 |
| Jahoor, F; Shangraw, RE | 1 |
| Bangsbo, J; Gibala, MJ; Howarth, KR; Krustrup, P | 1 |
| Kakimoto, N; Katayama, K; Koga, Y; Matsuishi, T; Naito, E; Povalko, N; Tanaka, M | 1 |
3 trial(s) available for alanine and dichloroacetic acid
| Article | Year |
|---|---|
Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders.
Topics: Acetylcysteine; Adenosine Diphosphate; Adolescent; Adult; Aged; Alanine; Brain; Child; Creatine; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Female; Humans; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondrial Myopathies; Placebos; Pyruvate Dehydrogenase Complex | 1995 |
Dichloroacetate inhibits peripheral efflux of pyruvate and alanine during hormonally simulated catabolic stress.
Topics: Adult; Alanine; Dichloroacetic Acid; Epinephrine; Glucagon; Glucose; Humans; Hydrocortisone; Male; Muscle Proteins; Nitrogen; Pyruvates; Pyruvic Acid; Wounds and Injuries | 1993 |
Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis.
Topics: Adult; Alanine; C-Peptide; Dichloroacetic Acid; Female; Gas Chromatography-Mass Spectrometry; Glucagon; Humans; Insulin; Kinetics; Lactates; Liver; Liver Cirrhosis; Male; Oxidation-Reduction; Pyruvic Acid | 2004 |
28 other study(ies) available for alanine and dichloroacetic acid
| Article | Year |
|---|---|
Defective activation of the pyruvate dehydrogenase complex in subacute necrotizing encephalomyelopathy (Leigh disease).
Topics: Alanine; Blood Glucose; Brain; Brain Diseases; Decarboxylation; Dichloroacetic Acid; Enzyme Activation; Fibroblasts; Humans; In Vitro Techniques; Infant; Liver; Necrosis; Phosphorylation; Pyruvate Dehydrogenase Complex Deficiency Disease; Syndrome | 1979 |
Relationship between lactate and glutamine metabolism in vitro by the kidney: differences between dog and rat and importance of alanine synthesis in the dog.
Topics: Acidosis; Alanine; Aminooxyacetic Acid; Animals; Dichloroacetic Acid; Dogs; Fluoroacetates; Gluconeogenesis; Glutamine; Kidney Cortex; Lactates; Rats | 1979 |
Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia.
Topics: Acetates; Acidosis; Adult; Aged; Alanine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus; Dichloroacetic Acid; Female; Humans; Hyperlipidemias; Ketone Bodies; Lactates; Male; Middle Aged; Triglycerides | 1978 |
Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids; Animals; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Female; Glucose; Glycerol; Insulin; Lactates; Muscles; Perfusion; Pyruvates; Rats; Starvation | 1978 |
Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion.
Topics: Absorption; Adult; Alanine; Burns; Carbon Isotopes; Child; Child, Preschool; Dichloroacetic Acid; Energy Metabolism; Glucose; Humans; Infusions, Intravenous; Lactates; Lactic Acid; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Reference Values | 1991 |
Transamination and oxidative decarboxylation of L-isoleucine, L-alloisoleucine and related 2-oxo acids in perfused rat hind limb muscle.
Topics: Alanine; Amination; Amino Acids, Branched-Chain; Animals; Decarboxylation; Dichloroacetic Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Isoleucine; Male; Muscles; Oxidation-Reduction; Phenylalanine; Rats; Rats, Inbred Strains; Stereoisomerism | 1989 |
Pharmacologic modulation of increased release of gluconeogenic precursors from extra-splanchnic organs in sepsis.
Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Cycloserine; Dichloroacetic Acid; Gluconeogenesis; Glutamate-Ammonia Ligase; Glutamine; Hepatectomy; Intestine, Small; Lactates; Lactic Acid; Liver; Male; Methionine Sulfoximine; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Sepsis | 1989 |
Effects of gluconeogenic precursor flux alterations on glycogen resynthesis after prolonged exercise.
Topics: Alanine; Animals; Blood Glucose; Dichloroacetic Acid; Fatty Acids, Nonesterified; Gluconeogenesis; Glycerol; Glycogen; Lactates; Liver Glycogen; Male; Muscles; Nicotinic Acids; Physical Exertion; Propranolol; Rats; Rats, Inbred Strains | 1987 |
Comparative metabolic effects of acetate and dichloroacetate infusion in the anesthetized dog.
Topics: Acetates; Alanine; Animals; Bicarbonates; Blood Glucose; Carbon Dioxide; Dichloroacetic Acid; Dogs; Electrolytes; Fasting; Fatty Acids; Hydrogen-Ion Concentration; Insulin; Lactates; Oxygen; Phosphates; Pyruvates | 1985 |
Contribution of the liver and extrasplanchnic tissues to the hypoglycemic action of dichloroacetate in the conscious dog.
Topics: Acetates; Alanine; Animals; Dichloroacetic Acid; Dogs; Epinephrine; Glucagon; Glucose; Hypoglycemia; Insulin; Lactates; Liver; Norepinephrine; Somatostatin | 1982 |
Amino acid oxidation and alanine production in rat hemidiaphragm in vitro. Effects of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids; Animals; Aspartic Acid; Diaphragm; Dichloroacetic Acid; Glucose; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Muscles; Oxidation-Reduction; Rats; Rats, Inbred Strains; Starvation | 1984 |
Mitochondrial compartmentation of metabolic CO2 resulting from its site of origin in relation to urea synthesis.
Topics: Acetazolamide; Alanine; Animals; Carbon Dioxide; Cell Compartmentation; Dichloroacetic Acid; Formates; Glutamates; Glutamic Acid; Liver; Mitochondria, Liver; Pyruvates; Rats; Rats, Inbred Strains; Urea | 1984 |
Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids, Branched-Chain; Animals; Dichloroacetic Acid; In Vitro Techniques; Male; Muscles; Rats; Rats, Inbred Strains; Starvation | 1984 |
Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA).
Topics: Acetates; Acidosis; Alanine; Diazoxide; Dichloroacetic Acid; Humans; Hypoglycemia; Infant; Infant, Newborn; Lactates; Male | 1983 |
Treatment of lactic acidosis with dichloroacetate.
Topics: 3-Hydroxybutyric Acid; Acetates; Acidosis; Adolescent; Adult; Aged; Alanine; Bicarbonates; Blood Pressure; Dichloroacetic Acid; Female; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Lactates; Lactic Acid; Male; Middle Aged | 1983 |
The effect of dichloroacetate and hydroxypyruvate on the entry of 14C from [1-14C]alanine into urea in rat hepatocytes.
Topics: Acetates; Alanine; Animals; Carbon Radioisotopes; Dichloroacetic Acid; Kinetics; Liver; Pyruvates; Rats; Urea | 1983 |
Dichloroacetate--its in vivo effects on carbohydrate metabolism in the conscious dog.
Topics: Acetates; Alanine; Amino Acids; Animals; Dichloroacetic Acid; Dogs; Female; Glucagon; Gluconeogenesis; Glucose; Glycerol; Insulin; Kinetics; Liver; Male | 1980 |
Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver.
Topics: Acetates; Alanine; Animals; Dichloroacetic Acid; Dogs; Female; Gluconeogenesis; Kinetics; Lactates; Lactic Acid; Liver; Male | 1981 |
Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans.
Topics: Acetates; Adult; Alanine; Blood Glucose; Dichloroacetic Acid; Female; Humans; Kinetics; Lactates; Male; Metabolic Clearance Rate; Middle Aged | 1980 |
Mechanisms by which dichloroacetate lowers lactic acid levels: the kinetic interrelationships between lactate, pyruvate, alanine, and glucose.
Topics: Alanine; Animals; Blood Glucose; Dichloroacetic Acid; Dogs; Epinephrine; Glucagon; Glucose; Glycolysis; Hindlimb; Kinetics; Lactates; Male; Pyruvates; Somatostatin; Time Factors | 1994 |
In vivo metabolic response of glucose to dichloroacetate in humans.
Topics: Adult; Alanine; Dichloroacetic Acid; Feedback; Glucose; Humans; Hyperglycemia; Lactates; Lactic Acid; Male; Muscle, Skeletal | 1996 |
Dichloroacetate inhibits glutamine oxidation by decreasing pyruvate availability for transamination.
Topics: Alanine; Animals; Cell Line; Cell Survival; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glutamine; Hybridomas; Oxidation-Reduction; Pyruvic Acid; Time Factors | 1997 |
The effect of dichloroacetate and alanine on the metabolic recovery of perfused mouse liver after cold ischemia.
Topics: Adenosine; Alanine; Allopurinol; Animals; Carbon Isotopes; Cold Temperature; Cryopreservation; Dichloroacetic Acid; Fasting; Glutamine; Glutathione; Insulin; Ischemia; Liver; Male; Mice; Nuclear Magnetic Resonance, Biomolecular; Organ Preservation; Organ Preservation Solutions; Phosphorus; Raffinose; Reperfusion Injury; Tissue Donors | 1999 |
Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.
Topics: Acetyl Coenzyme A; Alanine; Animals; Buffers; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glucose; Heart; Heart Function Tests; Heart Rate; Hypoglycemic Agents; In Vitro Techniques; Insulin; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardium; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2003 |
Low-frequency modes of peptides and globular proteins in solution observed by ultrafast OHD-RIKES spectroscopy.
Topics: Alanine; Animals; Biophysical Phenomena; Biophysics; Dichloroacetic Acid; Hydrogen; Lactalbumin; Lactoglobulins; Muramidase; Neutrons; Pepsin A; Peptides; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Scattering, Radiation; Spectrum Analysis, Raman; Time Factors | 2003 |
Multinuclear NMR investigations on the metabolic recovery of the isolated perfused mouse liver after cold preservation.
Topics: Alanine; Animals; Carbon Isotopes; Cryopreservation; Dichloroacetic Acid; Enzyme Activation; Fasting; Ketone Oxidoreductases; Liver; Liver Glycogen; Male; Mice; Microcirculation; Nuclear Magnetic Resonance, Biomolecular; Perfusion; Recovery of Function; Triglycerides | 2003 |
Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake.
Topics: Adult; Alanine; Biopsy; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Exercise; Exercise Test; Humans; Kinetics; Knee; Male; Muscle, Skeletal; Oxidation-Reduction; Oxygen Consumption; Supine Position | 2006 |
Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene.
Topics: Alanine; Cells, Cultured; Child, Preschool; Dichloroacetic Acid; Electroencephalography; Fibroblasts; Humans; Lactic Acid; Leigh Disease; Male; Mutation; Pyruvate Dehydrogenase (Lipoamide); Pyruvic Acid; Statistics, Nonparametric | 2012 |