alanine and deuterium oxide

alanine has been researched along with deuterium oxide in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (9.68)18.2507
2000's20 (64.52)29.6817
2010's7 (22.58)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Cerdán, S; Erhard, P; Moldes, M; Seelig, J1
Malthouse, JP; Phelan, P1
Alvarez, J; Cerdán, S; Cruz, F; García-Espinosa, MA; García-Martín, M; Moldes, M1
Kinch, LN; Phillips, MA1
Breton, J; Hanson, DK; Joshi, HM; Nabedryk, E1
Hitomi, K; Ishikawa, T; Iwai, S; Kim, ST; Mizukoshi, T; Nakamura, H; Todo, T1
Golbik, R; Hübner, G; Jordan, F; Seliger, B; Spinka, M; Tittmann, K; Wang, J1
Jung, MK; Nogales, E; Oakley, BR; Oakley, CE; Prigozhina, N1
Eker, F; Griebenow, K; Huang, Q; Schweitzer-Stenner, R1
Decatur, SM; Nguyen, JY; Silva, RA1
Chapman, SK; Miles, CS; Mowat, CG; Reid, GA; Rothery, EL; Walkinshaw, MD1
Furutani, Y; Kamo, N; Kandori, H; Shimono, K; Sudo, Y1
Alexander, JC; Brunengraber, H; Chandramouli, V; Fatica, R; Landau, BR; Previs, SF1
Bederman, IR; Brunengraber, DZ; Dufner, DA; Ismail-Beigi, F; Kimball, SR; Previs, SF; Rachdaoui, N; Siegfried, BA1
Do, SH; Jeong, KS; Jeong, W; Kim, YK; Lee, J; Noh, DH1
Alexander, JC; Bederman, IR; Dufner, DA; Previs, SF1
He, X; Jiang, Y; Ortiz de Montellano, PR1
Bazhulina, NP; Demidkina, TV; Faleev, NG; Gollnick, PD; Kulikova, VV; Papisova, AI; Phillips, RS1
Hochstrasser, RM; Kim, YS1
Abdallah, P; Allain, G; Basset, A; Belloto, E; Beylot, M; Diraison, F1
Awada, M; Bautista, A; Gardner, JL; Hellerstein, MK; Lindwall, G; Turner, SM1
Borsacchi, S; Catalano, D; Veracini, CA1
Ghomi, M; Hernández, B; Nsangou, M; Pflüger, F1
Cimpoiaşu, VM; Popa, R; Scorei, RI1
Kerwin, BA; Mozziconacci, O; Schöneich, C1
Neefus, CD; Pu, Q; Tillinghast, EK; Townley, MA; Zercher, CK1
Bechshoeft, R; Ebenstein, D; Holm, L; Holstein-Rathlou, NH; Kjaer, M; Matthews, DE; O'Rourke, B; Toth, MJ1
Balashov, SP; Dioumaev, AK; Dolgikh, DA; Imasheva, ES; Kirpichnikov, MP; Lanyi, JK; Lukashev, EP; Petrovskaya, LE; Rubin, AB; Sychev, SV; Wang, JM1
Chin, J; Moozeh, K; So, SM1
Jones, J; Marques, C; Rito, J; Viegas, F; Viegas, I1
Munakata, K; Nakagawa, M; Sumi, K; Yamada, K; Yoshida, N1

Trials

1 trial(s) available for alanine and deuterium oxide

ArticleYear
Quantifying rates of protein synthesis in humans by use of 2H2O: application to patients with end-stage renal disease.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:4

    Topics: Adult; Aged; Alanine; Body Water; Deuterium Oxide; Female; Humans; Hydrogen; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Molecular Weight; Protein Biosynthesis; Renal Dialysis; Serum Albumin

2004

Other Studies

30 other study(ies) available for alanine and deuterium oxide

ArticleYear
1H-2H exchange in the perfused rat liver metabolizing [3-13C]alanine and 2H2O as detected by multinuclear NMR spectroscopy.
    NMR in biomedicine, 1994, Volume: 7, Issue:6

    Topics: Alanine; Animals; Aspartic Acid; Carbon Isotopes; Deuterium; Deuterium Oxide; Glutamic Acid; Hydrogen; Liver; Magnetic Resonance Spectroscopy; Male; Perfusion; Rats; Rats, Sprague-Dawley

1994
1H-NMb spectroscopy of beta-thiocyanatoalanine.
    Biochemical Society transactions, 1996, Volume: 24, Issue:1

    Topics: Alanine; Deuterium Oxide; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Thiocyanates

1996
Effects of heavy water on hepatic intracellular pH and phosphatidylcholine turnover. A 31P NMR study.
    Cellular and molecular biology (Noisy-le-Grand, France), 1997, Volume: 43, Issue:5

    Topics: Alanine; Amiloride; Animals; Deuterium Oxide; Hydrogen-Ion Concentration; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Perfusion; Phosphatidylcholines; Phospholipases; Phosphorus Isotopes

1997
Single-turnover kinetic analysis of Trypanosoma cruzi S-adenosylmethionine decarboxylase.
    Biochemistry, 2000, Mar-28, Volume: 39, Issue:12

    Topics: Adenosylmethionine Decarboxylase; Alanine; Animals; Binding Sites; Catalysis; Cysteine; Decarboxylation; Deuterium Oxide; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Putrescine; Schiff Bases; Trypanosoma cruzi

2000
Fourier transform infrared evidence of proton uptake by glutamate L212 upon reduction of the secondary quinone QB in the photosynthetic reaction center from Rhodobacter capsulatus.
    Biochemistry, 2000, Nov-28, Volume: 39, Issue:47

    Topics: Alanine; Amino Acid Substitution; Deuterium Oxide; Glutamic Acid; Glutamine; Kinetics; Light; Mutagenesis, Site-Directed; Oxidation-Reduction; Photosynthetic Reaction Center Complex Proteins; Protein Conformation; Protons; Quinones; Rhodobacter capsulatus; Spectroscopy, Fourier Transform Infrared; Water

2000
Role of two histidines in the (6-4) photolyase reaction.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Deoxyribodipyrimidine Photo-Lyase; Deuterium Oxide; DNA Repair; Glutamine; Histidine; Hydrogen-Ion Concentration; Leucine; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protons; Sequence Homology, Amino Acid; Substrate Specificity; Time Factors; Tryptophan; Xenopus

2001
Consequences of a modified putative substrate-activation site on catalysis by yeast pyruvate decarboxylase.
    Biochemistry, 2001, Feb-13, Volume: 40, Issue:6

    Topics: Alanine; Catalysis; Cysteine; Deuterium Oxide; Enzyme Activation; Hydrogen; Kinetics; Models, Chemical; Pyruvate Decarboxylase; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Solvents; Substrate Specificity; Thiamine Pyrophosphate; Thiazoles

2001
Alanine-scanning mutagenesis of Aspergillus gamma-tubulin yields diverse and novel phenotypes.
    Molecular biology of the cell, 2001, Volume: 12, Issue:7

    Topics: Alanine; Alleles; Aspergillus nidulans; Benomyl; Deuterium Oxide; Fungal Proteins; Genes, Fungal; Microtubule-Associated Proteins; Models, Molecular; Mutagenesis, Site-Directed; Nocodazole; Phenotype; Protein Structure, Tertiary; Tubulin

2001
Dihedral angles of trialanine in D2O determined by combining FTIR and polarized visible Raman spectroscopy.
    Journal of the American Chemical Society, 2001, Oct-03, Volume: 123, Issue:39

    Topics: Alanine; Deuterium Oxide; Glycine; Peptides; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman

2001
Probing the effect of side chains on the conformation and stability of helical peptides via isotope-edited infrared spectroscopy.
    Biochemistry, 2002, Dec-24, Volume: 41, Issue:51

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Carbon Isotopes; Circular Dichroism; Deuterium Oxide; Leucine; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Conformation; Protein Structure, Secondary; Repetitive Sequences, Amino Acid; Spectrophotometry, Infrared; Thermodynamics

2002
Histidine 61: an important heme ligand in the soluble fumarate reductase from Shewanella frigidimarina.
    Biochemistry, 2003, Nov-18, Volume: 42, Issue:45

    Topics: Alanine; Crystallization; Crystallography, X-Ray; Cytochrome c Group; Deuterium Oxide; Electron Transport; Flavin-Adenine Dinucleotide; Heme; Histidine; Kinetics; Ligands; Methionine; Molecular Weight; Mutagenesis, Site-Directed; Potentiometry; Shewanella; Solubility; Solvents; Succinate Dehydrogenase

2003
Hydrogen bonding alteration of Thr-204 in the complex between pharaonis phoborhodopsin and its transducer protein.
    Biochemistry, 2003, Dec-09, Volume: 42, Issue:48

    Topics: Alanine; Amino Acid Substitution; Archaeal Proteins; Carotenoids; Deuterium Oxide; Halorhodopsins; Hydrogen Bonding; Natronobacterium; Phenylalanine; Photoreceptors, Microbial; Sensory Rhodopsins; Serine; Spectroscopy, Fourier Transform Infrared; Threonine; Tyrosine

2003
Using 2H2O to study the influence of feeding on protein synthesis: effect of isotope equilibration in vivo vs. in cell culture.
    American journal of physiology. Endocrinology and metabolism, 2005, Volume: 288, Issue:6

    Topics: Alanine; Animals; Carrier Proteins; Cell Culture Techniques; Cell Line; Deuterium Oxide; Intracellular Signaling Peptides and Proteins; Male; Phosphoproteins; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Serum Albumin

2005
Measurement of estrogen effect on bone turnover by 2H2O labeling.
    Calcified tissue international, 2005, Volume: 76, Issue:5

    Topics: Alanine; Animals; Body Weight; Bone Matrix; Bone Remodeling; Deuterium Oxide; Drug Implants; Estradiol; Extracellular Matrix Proteins; Female; Femur; Osteoclasts; Ovariectomy; Rats; Rats, Sprague-Dawley

2005
Novel application of the "doubly labeled" water method: measuring CO2 production and the tissue-specific dynamics of lipid and protein in vivo.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:5

    Topics: Alanine; Animals; Carbon Dioxide; Deuterium Oxide; Epididymis; Gas Chromatography-Mass Spectrometry; Glycerol; Glycerophosphates; Isotope Labeling; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Models, Biological; Myocardium; Oxygen Isotopes; Proteins; Reproducibility of Results; Triglycerides; Trimethylsilyl Compounds; Water

2006
Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.
    Biochemistry, 2006, Jan-17, Volume: 45, Issue:2

    Topics: Alanine; Amino Acid Substitution; Bacterial Proteins; Bicyclic Monoterpenes; Camphor 5-Monooxygenase; Catalysis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Deuterium Oxide; Free Radicals; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Hydroxylation; Isomerism; Leucine; Monoterpenes; Oxidation-Reduction

2006
Aspartic acid 214 in Citrobacter freundii tyrosine phenol-lyase ensures sufficient C--H-acidity of the external aldimine intermediate and proper orientation of the cofactor at the active site.
    Biochimica et biophysica acta, 2006, Volume: 1764, Issue:7

    Topics: Alanine; Apoenzymes; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Citrobacter freundii; Coenzymes; Deuterium Oxide; Homoserine; Kinetics; Molecular Structure; Mutation; Phenylalanine; Recombinant Fusion Proteins; Spectrophotometry; Tyrosine; Tyrosine Phenol-Lyase

2006
Dynamics of amide-I modes of the alanine dipeptide in D2O.
    The journal of physical chemistry. B, 2005, Apr-14, Volume: 109, Issue:14

    Topics: Alanine; Amides; Deuterium Oxide; Dipeptides; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Oscillometry; Protein Structure, Secondary; Proteins; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Temperature; Thermodynamics; Time Factors; Water

2005
Determination of protein replacement rates by deuterated water: validation of underlying assumptions.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:5

    Topics: Adult; Alanine; Animals; Apolipoprotein B-100; Deuterium Oxide; Female; Humans; Kinetics; Liver; Male; Middle Aged; Muscle, Skeletal; Myocardium; Peptide Biosynthesis; Rats; Rats, Wistar; Receptors, LDL

2007
Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:6

    Topics: Administration, Oral; Alanine; Animals; Atorvastatin; Carbon Tetrachloride; Collagen; Deuterium Oxide; Drug Evaluation, Preclinical; Enalapril; Gas Chromatography-Mass Spectrometry; Griseofulvin; Heptanoic Acids; Hydroxyproline; Interferon-gamma; Liver; Liver Cirrhosis, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrroles; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Rosiglitazone; Species Specificity; Thiazolidinediones; Time Factors

2007
Structure and orientation of small molecules dissolved in the liquid crystalline phases of CsPFO/water system by multinuclear NMR.
    Physical chemistry chemical physics : PCCP, 2009, May-28, Volume: 11, Issue:20

    Topics: Alanine; Deuterium Oxide; Fluorocarbons; Magnetic Resonance Spectroscopy; Micelles; Models, Molecular; Molecular Conformation; Organometallic Compounds; Phenylalanine; Pyridines; Water

2009
Vibrational analysis of amino acids and short peptides in hydrated media. IV. Amino acids with hydrophobic side chains: L-alanine, L-valine, and L-isoleucine.
    The journal of physical chemistry. B, 2009, Mar-12, Volume: 113, Issue:10

    Topics: Alanine; Amino Acids; Carbon; Deuterium Oxide; Hydrogen; Isoleucine; Leucine; Models, Theoretical; Molecular Conformation; Peptides; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Valine; Water

2009
Enantiodifferent proton exchange in alanine and asparagine in the presence of H(2)(17)O.
    Journal of molecular evolution, 2010, Volume: 71, Issue:1

    Topics: Alanine; Asparagine; Deuterium Oxide; Magnetic Resonance Spectroscopy; Oxygen Isotopes; Stereoisomerism

2010
Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine.
    The journal of physical chemistry. B, 2011, Oct-27, Volume: 115, Issue:42

    Topics: Alanine; Amino Acid Sequence; Cysteine; Deuterium Exchange Measurement; Deuterium Oxide; Free Radicals; Hydrogen; Hydrogen-Ion Concentration; Peptides; Photolysis; Thermodynamics

2011
Small organic solutes in sticky droplets from orb webs of the spider Zygiella atrica (Araneae; Araneidae): β-alaninamide is a novel and abundant component.
    Chemistry & biodiversity, 2012, Volume: 9, Issue:10

    Topics: Alanine; Amides; Animals; Deuterium Oxide; Magnetic Resonance Spectroscopy; Putrescine; Silk; Spiders

2012
Determination of steady-state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans.
    American journal of physiology. Endocrinology and metabolism, 2013, Apr-15, Volume: 304, Issue:8

    Topics: Alanine; Amino Acids; Animals; Blood Proteins; Body Water; Deuterium Oxide; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Kinetics; Male; Models, Biological; Rats; Rats, Sprague-Dawley

2013
Breaking the carboxyl rule: lysine 96 facilitates reprotonation of the Schiff base in the photocycle of a retinal protein from Exiguobacterium sibiricum.
    The Journal of biological chemistry, 2013, Jul-19, Volume: 288, Issue:29

    Topics: Absorption; Alanine; Amino Acid Substitution; Bacterial Proteins; Biological Transport; Deuterium Oxide; Escherichia coli; Halobacterium; Hydrogen-Ion Concentration; Kinetics; Light; Liposomes; Lysine; Mutant Proteins; Protons; Schiff Bases; Sodium Azide; Time Factors

2013
Catalytic Stereoinversion of L-Alanine to Deuterated D-Alanine.
    Angewandte Chemie (International ed. in English), 2015, Aug-03, Volume: 54, Issue:32

    Topics: Alanine; Catalysis; Chloroform; Deuterium; Deuterium Oxide; Magnetic Resonance Spectroscopy; Stereoisomerism; Thermodynamics

2015
Determination of muscle protein synthesis rates in fish using (2)H2O and (2)H NMR analysis of alanine.
    Analytical biochemistry, 2016, 09-15, Volume: 509

    Topics: Alanine; Animals; Bass; Deuterium Oxide; Fish Proteins; Nuclear Magnetic Resonance, Biomolecular; Protein Biosynthesis

2016
Application of elemental analysis-coupled isotope ratio mass spectrometry for protein turnover analysis using deuterium labeling: Purification and analysis of hydrogen isotope ratio of non-derivatized protein-bound alanine.
    Rapid communications in mass spectrometry : RCM, 2023, Jun-30, Volume: 37, Issue:12

    Topics: Alanine; Animals; Deuterium; Deuterium Oxide; Hydrogen; Insulins; Isotope Labeling; Mass Spectrometry; Mice

2023