alanine has been researched along with cysteine in 961 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 257 (26.74) | 18.7374 |
| 1990's | 186 (19.35) | 18.2507 |
| 2000's | 335 (34.86) | 29.6817 |
| 2010's | 149 (15.50) | 24.3611 |
| 2020's | 34 (3.54) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Brandsch, M; Gebauer, S; Laug, L; Schäfer, S; Thondorf, I; Voigt, V; Zebisch, K | 1 |
| Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S | 1 |
| Ebert, C; Ebert, G; Rossmeissl, G | 1 |
| Kim, CY; Sternberg, M | 1 |
| Narukawa, M | 1 |
| Shimizu, H; Yamamura, Y | 1 |
| Szajer, C | 1 |
| Dingwall, C; Fersht, AR | 1 |
| Barton, BP; Faguet, GB; Garver, FA; Smith, LL | 1 |
| Ellory, JC; Jones, SE; Wolowyk, MW; Young, JD | 1 |
| Kajiyama, KI; Nakayama, F; Sakamoto, M | 1 |
| Conn, EE; Creveling, RK; Floss, HG; Mazelis, M; Tsai, MD; Weaver, J | 1 |
| Ellory, JC; Young, JD | 1 |
| Ho, CK; Kern, HL; Ostrove, SA | 1 |
| Coughlan, MP | 1 |
| Gross, E | 1 |
| Cannon, WO; Frolichstein, CF; Martin, JF; Olney, JW; Perez, VJ | 1 |
| Davis, L; Kapke, G | 1 |
| Gosalvez, M; Weinhouse, S | 1 |
| Casey, R; Lang, A | 1 |
| Muller, LD; Rodriguez, D | 1 |
| Asch, HL; Read, CP | 1 |
| Gundalakh, AI; Mel'k, MV; Shcheglova, SA; Volkova, ZA | 1 |
| Guadalix, FJ; Ruiz, MC | 1 |
| Kester, AS; Mayfield, DC | 1 |
| Finley, JW; Friedman, M; Snow, JT | 1 |
| Benassi, CA; Guggi, A; Rocchi, R; Salvadori, S; Tomatis, R | 1 |
| Heinrich, D; Kubli, F; Metz, J; Wesch, H | 1 |
| Ellory, JC; Tucker, EM; Young, JD | 1 |
| Delers, F; Engler, R; Grimble, RF; Jackson, AA; Persaud, C; Wride, MJ | 1 |
| Choe, HW; Grunert, HP; Hahn, U; Heinemann, U; Koellner, G; Saenger, W; Zouni, A | 1 |
| Akasaka, T; Ono, N; Sawai, T; Yamaguchi, A | 1 |
| Fukamachi, H; Iijima, H; Ishikawa, M; Iwamatsu, A; Kadoya, T; Kobayashi, K; Matsuki, S; Satake-Ishikawa, R; Shimada, Y; Tsumura, H | 1 |
| Anderson, S; Falick, AM; Kosen, PA; Kuntz, ID; Marks, CB | 1 |
| Standring, DN; Zhou, S | 1 |
| Miller, SM; Moore, MJ; Walsh, CT | 1 |
| Lee, GJ; McFadden, BA | 1 |
| Katzenellenbogen, BS; Reese, JC | 1 |
| Prakash, L; Prakash, S; Sung, P | 2 |
| Dröge, W; Eck, HP; Gmünder, H | 1 |
| Andersson, M; Bergenhem, N; Carlsson, U; Jonsson, BH; Kihlgren, A; Mårtensson, LG | 1 |
| Dyson, HJ; Hoey, K; Lerner, RA; Norrby, E; Parks, DE; Wright, PE | 1 |
| Cohen, S; Flashner, Y; Gozes, Y; Grosfeld, H; Kronman, C; Lazar, A; Leitner, M; Marcus, D; Shafferman, A; Velan, B | 1 |
| Ploch, SA; Smith, DJ | 1 |
| Hallinan, EA | 1 |
| Sen, SK | 1 |
| Fuchs, JA; Langsetmo, K; Woodward, C | 1 |
| Remesar, X; Rodríguez-Martín, A | 1 |
| Holden, HM; Jacobson, BL; Krezel, AM; Markley, JL; Oh, BH; Rayment, I; Skjeldal, L; Westler, WM | 1 |
| Amioka, H; Dojo, S; Hayashi, K; Hiraoka, M; Hirata, Y; Kurushima, H; Nakashima, K; Nishio, E; Ohtani, H; Saeki, M | 1 |
| Chang, JY; Knecht, R | 1 |
| Nekliudov, AD | 1 |
| Berry, A; Deonarain, MP; Perham, RN; Scrutton, NS | 1 |
| Bass, SH; Mulkerrin, MG; Wells, JA | 1 |
| Inaka, K; Kikuchi, M; Matsushima, M; Morikawa, K; Taniyama, Y | 1 |
| Hakvoort, TB; Margoliash, E; Sprinkle, JR | 1 |
| Mullins, LS; Raushel, FM; Walsh, CT; Zawadzke, LE | 1 |
| Hojo, K; Kanegae, T; Mieda, Y; Nagoya, T; Nomura, M; Okubo, H; Shimamura, M; Tsukamoto, S | 1 |
| Gavel, Y; von Heijne, G | 1 |
| Ahern, JD; Balishin, NL; Defeo-Jones, D; Edwards, GM; FitzGerald, DJ; Heimbrook, DC; Oliff, A; Pastan, I; Patrick, DR; Stirdivant, SM | 1 |
| Getzoff, ED; Hallewell, RA; Lepock, JR; McRee, DE; Redford, SM; Tainer, JA | 1 |
| Kilberg, MS; Mailliard, ME | 1 |
| Brzović, P; Dunn, MF; Greene, RC; Holbrook, EL | 1 |
| Beale, D; Coadwell, J | 1 |
| Schuster, SM; Van Heeke, G | 1 |
| Liwo, A; Tarnowska, M; Tempczyk, A | 1 |
| Houghten, RA; Lerner, RA; Norrby, E; Parks, DE; Utter, G | 1 |
| LaVelle, JM; Mangold, JB; Mischke, MR | 1 |
| Cavallini, D; Costa, M; Fontana, M; Pecci, I; Pensa, B | 1 |
| De La Rosa, J; Hirschberger, LL; Stipanuk, MH | 1 |
| Hoeltzli, SD; Smith, CH | 1 |
| Moseley, RH; Murphy, SM | 1 |
| Kato, H; Kimura, A; Nishioka, T; Oda, J; Tanaka, T | 1 |
| Nakabeppu, Y; Sekiguchi, M; Takano, K | 1 |
| Kiick, DM; Phillips, RS | 2 |
| Cullis, PM; Kleanthous, C; Lewendon, A; Murray, IA; Shaw, WV | 1 |
| Bannai, S; Ishii, T; Sato, H; Watanabe, H | 1 |
| Bourre, JM; Lefauconnier, JM; Roux, F; Tayarani, I | 1 |
| Frasier-Scott, K; Hatzakis, H; Jones, CM; Seong, D; Wu, KK | 1 |
| Esaki, N; Karai, N; Nakamura, T; Soda, K; Tanaka, H | 1 |
| Clark-Lewis, I; Hood, LE; Kent, SB | 1 |
| Johnson, LW; Smith, CH | 1 |
| Barr, PJ; Gibson, HL; Hallewell, RA; Matheson, NR; Travis, J | 1 |
| Profy, AT; Schimmel, P | 1 |
| Nigrovic, V; Smith, S | 1 |
| Cavallini, D; Federici, G; Nardini, M; Ricci, G | 1 |
| Jacobson, E; Kurzawaski, G; Tustanowski, S | 1 |
| Hayashi, H; Hori, M; Sakata, N; Takeuchi, T; Umezawa, H; Yamato, M | 1 |
| Ikehara, M; Ohtsuka, E; Tanaka, T; Tokunaga, T | 1 |
| Katayama, I; Nishioka, K | 1 |
| Blocher, JC; Busta, FF | 1 |
| Christensen, HN; Vadgama, JV | 1 |
| Fincham, DA; Mason, DK; Young, JD | 1 |
| Kunert, J | 1 |
| Karlsson, JO; Sjöstrand, J | 1 |
| Fleet, GW; Knowles, JR; Porter, RR | 1 |
| George, DT; Rayfield, EJ; Wannemacher, RW | 1 |
| Kagamiyama, H; Matsubara, H; Shin, M; Wada, K | 1 |
| Genco, RJ; Karush, F; Tenenhouse, HS | 1 |
| Becker, FL; Kroll, WA; Schneider, JA | 1 |
| Schmid, A | 2 |
| Plapp, R; Strominger, JL | 1 |
| Mayer, D; Raake, W; Schmid, A | 1 |
| Hallberg, D; Soda, M | 1 |
| Yoshida, A | 1 |
| Hirsh, DI; Lipmann, F | 1 |
| Abrol, YP; Blumenthal, SG; Conn, EE; Hendrickson, HR | 1 |
| Crippa, PR; Tedeschi, RA; Vecli, A | 1 |
| Donelli, MG; Garattini, S; Rosso, R | 1 |
| Miyajima, R; Otsuka, S; Shiio, I | 1 |
| Suzuki, N; Tucker, D | 1 |
| Read, CP; Southworth, GC | 1 |
| Barker, HA; Jeng, IM; Somack, R | 1 |
| Kornecki-Gerrity, EH; Penney, DG | 1 |
| Lifshitz, F; Wapnir, RA | 1 |
| Andrews, AT | 1 |
| Kubacz, GJ | 1 |
| Lipsett, MN | 1 |
| Hirshfield, IN; Zamecnik, PC | 1 |
| Amons, R; Groene, A; Möller, W; Terhorst, C | 1 |
| Foote, LJ; Keenan, BS; Kredich, NM | 1 |
| Cassidy, PJ; Kahan, FM; Kahan, JS; Kropp, H | 1 |
| Van Campen, D | 1 |
| Dembinski, A; Konturek, SJ; Radecki, T; Thor, P | 1 |
| Katsoyannis, PG; Okada, Y; Zalut, C | 1 |
| Segal, S; States, B | 1 |
| Gebhart, E | 1 |
| Balasubramanian, M; Myers, RF | 1 |
| Carbonell, J; Felíu, JE; Marco, R; Sols, A | 1 |
| Chirgadze, YN; Shestopalov, BV; Venyaminov, SY | 1 |
| Jung, G; Ottnad, M; Rimpler, M | 1 |
| Hill, LJ; Martin, WG | 1 |
| Stevenson, KJ | 1 |
| Degani, Y; Patchornik, A | 1 |
| Bahadur, K; Singh, YP; Verma, ML | 1 |
| Read, CP; Ruff, MD | 1 |
| Magdon, E; Schröder, E; Semenov, L | 1 |
| Borek, E; Hay, J; Pillinger, DJ | 1 |
| Kumagai, H; Matsui, H; Ogata, K; Ohkishi, H; Yamada, H | 1 |
| Degani, Y; Patchornik, A; Spande, TF; Witkop, B | 1 |
| Korobkova, TP; Kovsharova, IN; Maximova, TS; Terekhova, LP | 1 |
| Margoliash, E; Nolan, C; Peterson, JD; Steiner, DF | 1 |
| Schechter, I | 1 |
| Nurmikko, V; Pyykkö, K | 1 |
| Hampton, JR | 2 |
| Roy, AK | 1 |
| Kumagai, H; Miles, EW | 1 |
| Conn, EE; Floss, HG; Hadwiger, L | 1 |
| Mäkinen, KK; Paunio, KU | 1 |
| Buu-Hoï, NP; Hauspie, R; Lambelin, G; Nicolle, J | 1 |
| Cylwik, B; Nowak, HF | 1 |
| Sierra, G | 1 |
| Jarvis, B | 1 |
| Farr, J; Jarvis, B | 1 |
| Abel, CA; Grey, HM; Prahl, JW | 1 |
| Castric, PA; Conn, EE | 1 |
| Jolley, CJ; Yankeelov, JA | 1 |
| Okaju, M; Shapshak, P | 1 |
| Chatagner, F; Deme, D | 1 |
| Chatagner, F; Guion-Rain, MC | 1 |
| Husain, I; Norris, RF; Poupard, JA | 1 |
| Adams, GE; Aldrich, JE; Bisby, RH; Cundall, RB; Redpath, JL; Willson, RL | 1 |
| De Marco, C; Rinaldi, A | 1 |
| Flavin, M; Posner, BI | 1 |
| Braunstein, AE; Goryachenkova, EV; Tolosa, EA; Willhardt, IH; Yefremova, LL | 1 |
| Haniu, M; Massey, V; Mayhew, S; Tanaka, M; Yasunobu, KT | 1 |
| Christensen, HN; Koser, BH | 1 |
| Hornig, D; Weber, F; Wiss, O | 1 |
| Damoglou, AP; Lindley, H; Stapleton, IW | 1 |
| Haniu, M; Massey, V; Matsueda, G; Mayhew, S; Tanaka, M; Yasunobu, KT | 1 |
| Markelova, SI; Zharikova, GG | 3 |
| Stapleton, IW; Weber, OA | 1 |
| Keiser, HR; Lovenberg, W; Sjoerdsma, A; Slavik, M | 1 |
| Asquith, RS; Shah, AV | 1 |
| Carminatti, H; Jiménez de Asúa, L; Leiderman, B; Rozengurt, E | 1 |
| Chen, SS; Duerre, JA; Walgate, JH | 1 |
| Anfinsen, CB; Arnon, R; Maron, E; Sela, M | 1 |
| Oppermann, W; Welge-Lüssen, L | 1 |
| Guest, JR; Yanofsky, C | 1 |
| Bernfield, M; Brimacombe, R; Jaouni, T; Leder, P; Nirenberg, M; Trupin, J | 1 |
| Dunnill, PM; Fowden, L | 1 |
| Khorana, HG; Morgan, AR; Wells, RD | 1 |
| Ebata, M; Miyazaki, K; Otsuka, H | 1 |
| Diven, WF; Johnston, MM | 1 |
| Hoshino, S; Tsubota, H | 1 |
| Adams, E | 1 |
| Crewther, WG; Nicholls, PW | 1 |
| Cook, ES; Nutini, LG; Tanaka, K; Tsuchiya, Y | 1 |
| Duggan, AW; Johnston, GA | 1 |
| Haber, E; Waterfield, M | 1 |
| Oguri, K; Shiraki, H; Tsukamoto, H; Yoshimura, H | 1 |
| Neuhoff, V; Weise, M | 1 |
| Morino, Y; Okamoto, M | 1 |
| Baranova, IP; Egorov, NS | 1 |
| Evered, DF; Wass, M | 1 |
| Basappa, SC; Rehácek, Z | 1 |
| McConnell, WB; Nigam, SN | 1 |
| Diller, A; Schirch, LV | 1 |
| Dintzis, HM; McMenamy, RH; Watson, F | 1 |
| Giovanelli, J; Mudd, SH | 1 |
| Kimura, T; Nagata, Y; Tsurugi, J | 1 |
| Atassi, MZ; Cheng, SH; Perlstein, MT | 1 |
| Kloss, G; Schwarz, E | 1 |
| Kickuth, R; Scheffer, F; Schlimme, E | 1 |
| Konovalova, ZB | 1 |
| Ansorge, S; Bohley, P | 1 |
| Ashmarin, IP; Diurnbaum, VI; Sadikova, NV; Stapanova, IS | 1 |
| Demeyer, DI; Henderickx, HK | 1 |
| Arends, M; Armstrong, DA; Lal, M; Wilkening, VG | 1 |
| Petit, JF; Roberts, WS; Strominger, JL | 1 |
| Blout, ER; Coleman, DL | 1 |
| Chou, C; Larin, FF; Rose, CM; Wurtman, RJ | 1 |
| King, KW; Rock, GC | 1 |
| Manahan, J; Mandl, I | 1 |
| Steenbergen, ST; Weinberg, ED | 1 |
| Gertner, D; Wagner, D; Zilkha, A | 1 |
| Schneider, G | 1 |
| Grecz, N; Rajan, KS; Tang, T | 1 |
| Conn, EE; Hendrickson, HR | 1 |
| Meister, A; Tate, SS | 1 |
| McCormick, DB; Sigel, H; Wright, LD | 1 |
| Anwar, RA; Narayanan, AS | 1 |
| Daniels, VG; Newey, H; Smyth, DH | 1 |
| Neish, WJ; Rylett, A | 1 |
| Ettlinger, L; Jlli, HU; Müller, J | 1 |
| Patchornik, A; Wilchek, M; Zioudrou, C | 1 |
| Martin, WG; Miraglia, RJ; Patrick, H; Spaeth, DG | 1 |
| Christian, JH; Waltho, JA | 1 |
| Hollomon, DW | 1 |
| Ebata, M; Otsuka, H; Takahashi, Y | 1 |
| Elinov, NP; Kashkin, AP | 1 |
| Blum, JJ; Owens, I | 1 |
| Harper, E; Scharrer, B; Seifter, S | 1 |
| Efron, ML; Mechanic, GL; Shih, VE | 1 |
| Carlisle, SA; Morse, GE; Willett, NP | 1 |
| Agnihotri, VP; Vaartaja, O | 1 |
| Archer, EG; Christensen, HN; Liang, M | 1 |
| Alter, SC; Cooney, DA; Jayaram, N; Levine, M; Swengros, SG | 1 |
| Fersht, AR; Tsui, WC | 1 |
| Hug, DH; Hunter, JK | 1 |
| Jones, DP; Lash, LH | 1 |
| Ida, S; Kuriyama, K; Nishimura, C | 1 |
| Dudley, RE; Klaassen, CD | 1 |
| Baker, DH; Finley, JW; Robbins, KR | 1 |
| Corcoran, DH; Ferguson, EW; Fretto, LJ; McKee, PA | 1 |
| Ellory, JC; Jones, SE; Young, JD | 1 |
| Kawakami, B; Nagasawa, T; Ohkishi, H; Tani, Y; Yamada, H | 1 |
| Dall'Asta, V; Franchi-Gazzola, R; Gazzola, GC; Guidotti, GG | 1 |
| Biber, J; Murer, H; Stange, G; Stieger, B | 1 |
| Friedman, M; Masri, MS | 1 |
| Gurtoo, HL; Hipkens, JH; Sharma, SD | 1 |
| Jahoor, F; Jaksic, T; Miller, RG | 1 |
| Hardman, MJ; Jones, KM; Kitson, KE; Kitson, TM; Tweedie, JW | 1 |
| Azzariti, A; Doonan, S; Giannattasio, S; Marra, E; Merafina, RS; Quagliariello, E | 1 |
| Li, J; Pickart, CM | 1 |
| Kim, PS; Lumb, KJ | 1 |
| Eckardt, S; Köhr, G; Lüddens, H; Monyer, H; Seeburg, PH | 1 |
| Kim, PS; Staley, JP | 1 |
| Campbell, DG; Cohen, P; Cohen, PT; Dalby, KN; MacKintosh, C; MacKintosh, RW | 1 |
| Gerchman, Y; Olami, Y; Padan, E; Rimon, A; Schuldiner, S | 1 |
| Ingendoh, A; Schmidt, B; Selmer, T; von Figura, K | 1 |
| Iida, M; Imanaka, T; Ito, K; Jinnouchi, H; Kamohara, S; Kan, M; Kanai, F; Nishioka, Y; Ohnishi, T; Todaka, M | 1 |
| Azzariti, A; Doonan, S; Giannattasio, S; Marra, E; Quagliariello, E | 1 |
| Bartels, CF; Bedows, E; Boime, I; Huth, JR; Ruddon, RW; Suganuma, N | 1 |
| Arakawa, T; Fox, GM; Holst, PL; Horan, TP; Narhi, LO; Prestrelski, SJ; Rees, DC; Schiffer, SG; Tsai, LB | 1 |
| Yadid, G; Youdim, MB; Zinder, O | 1 |
| Bassuk, JA; Folkman, MJ; Lane, TF; Sage, EH; Yost, JC | 1 |
| Forest, E; Golinelli, MP; Meyer, J; Petillot, Y | 1 |
| Honma, M; Kawai, J; Yamada, M | 1 |
| Claiborne, A; Hol, WG; Mande, SS; Parsonage, D | 1 |
| Offer, G; Sessions, R | 1 |
| Paravicini, G; Payton, MA; Proudfoot, AE; Scully, P; Wells, TN | 1 |
| Douglas, CP; Gottlieb, T; Siarakas, S | 1 |
| Islam, SA; Weaver, DL; Weaver, TD | 1 |
| Belikov, VM; Dementieva, IS; Faleev, NG; Gogoleva, OI; Zakomirdina, LN | 1 |
| Kim, EJ; Rea, PA; Zhen, RG | 1 |
| Maxon, ME; Tjian, R | 1 |
| Fujinaga, J; Gaillard, J; Lutz, M; Meyer, J | 1 |
| Langer, M; Lieber, A; Rétey, J | 1 |
| Bustin, M; Friedman, FK; Lehn, DA; Postnikov, YV; Robinson, RC; Shiloach, J | 1 |
| Hewish, DR; Macaulay, SL; Polites, M; Ward, CW | 1 |
| Harata, K; Jigami, Y; Muraki, M | 1 |
| Mason, AJ | 1 |
| Arola, L; Salvadó, MJ | 1 |
| Lane, LK | 1 |
| Bakker, A; Finkelstein, SD; Keller, G; Pricolo, VE; Przygodzki, R; Sayegh, R; Swalsky, PA | 1 |
| Bernstein, BE; Herriott, JR; Hoffman, RC; Horvath, S; Klevit, RE | 1 |
| Davidson, FF; Khorana, HG; Loewen, PC | 1 |
| Kelly, JW; McCutchen, SL | 1 |
| Dumont, S; Fournel, M; Veillette, A | 1 |
| Kennedy, ME; Limbird, LE | 1 |
| Boekhoff, I; Breer, H; Restrepo, D | 1 |
| Pryor, MJ; Wright, PJ | 1 |
| Balasubramanian, S; Boxer, SG; Lambright, DG | 1 |
| Haseltine, WA; Zazopoulos, E | 1 |
| Deshusses, J; Geindre, M; L'Hostis, C | 1 |
| Kahana, C; Tobias, KE | 1 |
| Dötsch, V; Oswald, RE; Wagner, G | 1 |
| Hampson, DR; Pickering, DS; Salter, MW; Taverna, FA | 1 |
| Galli, G; Grandi, G; Grifantini, R; Pratesi, C | 1 |
| Chiu, ML; Folcher, M; Griffin, P; Holt, T; Klatt, T; Thompson, CJ | 1 |
| Flint, DH | 1 |
| Allen, JM; Hutchinson, MJ | 1 |
| Hallmann, A; Schmidt, B; Selmer, T; Sumper, M; von Figura, K | 1 |
| Bell, EA; Brownson, DM; Li, CJ; Mabry, TJ; Perera, C | 1 |
| Kavanaugh, MP; Zerangue, N | 1 |
| Gaggelli, E; Grzonka, Z; Kasprzykowski, F; Kozlowski, H; Maccotta, A; Valensin, G | 1 |
| Apfel, CM; Lamour, FP; Lardelli, P | 1 |
| Eulitz, M; Janosch, P; Kolch, W; Mischak, H; Philipp, A; Schellerer, M; Seitz, T; Steen, H | 1 |
| Czaplinski, K; Peltz, SW; Weng, Y | 1 |
| Gloss, LM; Kirsch, JF; Spencer, DE | 1 |
| Roy, I | 1 |
| Kessler, H; König, W; Michael, K; Sandow, J; Wittmann, V | 1 |
| Ahn, SM; Chung, T; Kim, K; Lee, SM; Park, JW | 1 |
| Communi, D; Erneux, C | 1 |
| Hirashiki, I; Hiro, I; Ito, A; Ogata, F; Tsugeno, Y | 1 |
| Kojima, Y; Kurasaki, M; Yamaguchi, R | 1 |
| Adam, EJ; Adam, SA; Chi, NC | 1 |
| Behlke, J; Heidrich, K; Kriegel, T; Otto, A; Rush, J; Wenzel, KW | 1 |
| McFadden, BA; Rehman, A | 2 |
| Pardo, JP; Petrov, VV; Slayman, CW | 1 |
| Bradley, TM; Demple, B; Ding, H; Hidalgo, E; Leautaud, V | 1 |
| Honma, M; Ito, H; Kiuchi, M; Matsui, H; Murakami, T | 1 |
| Hober, S; Nilsson, B; Uhlén, M | 1 |
| Boime, I; Furuhashi, M; Kikkawa, F; Mizuochi, T; Moriwaki, T; Nakata, M; Suganuma, N; Tomoda, Y | 1 |
| George, SR; Jin, H; O'Dowd, BF; Zastawny, R | 1 |
| Ishizaka, K; Mikayama, T; Nakano, T; Sugie, K; Takakura, K; Tomura, T | 1 |
| Nwabisi, VC; Nwanze, EA | 1 |
| Casimiro, DR; Evans, RM; Kliewer, SA; Provencal, J; Sem, DS; Wright, PE | 1 |
| Muneyuki, E; Odaka, M; Yoshida, M | 1 |
| Bertoldi, M; Castellani, S; Dominici, P; Moore, PS; Voltattorni, CB | 1 |
| Acheson, NH; Di Flumeri, C; Keng, T | 1 |
| Cotten, JF; Welsh, MJ | 1 |
| Dierks, T; Schmidt, B; von Figura, K | 1 |
| Ageta, T; Duprè, S; Fontana, M; Kodama, H; Sugahara, K; Yu, S; Zhang, J | 1 |
| García-Arenal, F; Malpica, JM; Moreno, IM; Rodríguez-Cerezo, E | 1 |
| Chung, CH; Kang, MS; Kim, HS; Kwon, JA; Seol, JH; Yoo, SJ | 1 |
| Betz, H; Schloss, P; Sur, C | 1 |
| Albi, JL; Esteve, M; Gallardo, MA; Sánchez, J | 1 |
| Lo, B; Silverman, M | 1 |
| Marrone, L; Viswanatha, T | 1 |
| Cantacuzène, D; Harth-Fritschy, E | 1 |
| Davies, PL; DeLuca, CI; Jia, Z; Ye, Q | 1 |
| Gehrig, P; Gervasoni, P; Plückthun, A | 1 |
| Colella, TA; Engelhard, VH; Gulden, PH; Hunt, DF; Kittlesen, DJ; Shabanowitz, J; Shabanowitz, JA; Skipper, JC; Slingluff, CL; Thompson, LW | 1 |
| Dierks, T; Lecca, MR; Schmidt, B; von Figura, K | 1 |
| Gorbalenya, AE | 1 |
| Brennan, C; Hehir, MJ; Kantrowitz, ER; Nolte, M; Stec, B | 1 |
| Bolin, KA; Hanson, P; Millhauser, GL; Wright, SJ | 1 |
| Ramachandran, S; Ratnaparkhi, GS; Udgaonkar, JB; Varadarajan, R | 1 |
| Cambi, A; Neuhard, J; Vincenzetti, S; Vita, A | 1 |
| Blanot, D; Legrand, R; Masson, A; Nosal, F; Parquet, C; Schoot, B; van Heijenoort, J | 1 |
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| Bustos, D; Decher, N; Goldstein, M; González, W; Kiper, AK; Netter, MF; Ortiz-Bonnin, B; Ramírez, D; Rinné, S | 1 |
| Huo, L; van der Donk, WA | 1 |
| Boal, AK; Booker, SJ; Grove, TL; Schwalm, EL | 1 |
| Kobayashi, M; Kumano, T; Shimizu, S; Suzuki, T | 1 |
| Cai, R; Chen, C; Grewer, C; Guo, Z; Wang, J; Yuan, Y; Zhang, Z | 1 |
| Altegoer, F; Bange, G; Blauenburg, B; Fage, CD; Linne, U; Marahiel, MA; Mielcarek, A | 1 |
| McLuckey, SA; Pilo, AL; Zhao, F | 1 |
| Atkins, WM; Bouldin, SD; Guttman, M; Outten, CE; Scian, M | 1 |
| Ando, T; Ihara, K; Isogai, E; Katsube, S; Kim, S; Yoneyama, H | 1 |
| Mochizuki, M; Nishio, H; Tsuda, S; Yoshiya, T | 1 |
| Boonen, M; Gilis, F; Jadot, M; Staudt, C; Tevel, V | 1 |
| Simmonds, RS; Timkovich, R; Xing, M | 1 |
| Brahma, V; Garg, R; Karthikeyan, S; Sahni, G; Srivastava, R; Verma, L | 1 |
| AraUjo, TL; Azevedo-Santos, AP; da Silva, SA; Fontelles, JL; Fries, DM; Gaspar, RS; Laurindo, FR; Mastrogiovanni, M; Paes, AM; Sena, EM; Sousa, HR; Trostchansky, A | 1 |
| Asai, A; Inoue, Y; Iwamoto, K; Matsuno, K; Muraoka, D; Ogo, N; Taguchi, K; Uehara, Y | 1 |
| Yang, M; Zhang, C; Zhang, MZ; Zhang, S | 1 |
| Dong, L; Liu, Y | 1 |
| He, Z; Huang, Z; Liu, S; Liu, X; Wang, Z; Wu, Y; Zhou, J | 1 |
| Asami, T; Kamaura, M; Niida, A; Sakamoto, K; Sameshima, T; Sasaki, S; Yaguchi, M; Yonemori, K | 1 |
| Firkins, JL; Lapierre, H; Ouellet, DR; Pellerin, D; Sok, M | 1 |
| Bachhawat, AK; Chandel, A | 1 |
| Friedrich, MG; Oakley, AJ; Schey, KL; Truscott, RJW; Wang, Z | 1 |
| Aurousseau, MRP; Bethge, T; Blunck, R; Bowie, D; Herrmann, A; Liebsch, F; McGuire, H; Multhaup, G; Scolari, S | 1 |
| Gregory, JF; Kent, J; Kožich, V; Kraus, JP; Krijt, J; Křížková, M; Majtan, T; Ralat, MA; Sokolová, J | 1 |
| Dos Santos, PC | 1 |
| Es'haghi, Z; Hooshmand, S | 1 |
| Abd Elmoneim, H; Louedec, L; Mohy El Din, M; Norel, X; Senbel, A; Sharabi, F | 1 |
| Ayyar, BV; Hearty, S; O'Kennedy, R | 1 |
| Becher, E; Claußen, L; Eisen, S; Heese, A; Jehmlich, N; Purswani, J; Rohwerder, T | 1 |
| Brigaud, T; Chelain, E; Devillers, E; Gadais, C; Gasparik, V; Pytkowicz, J | 1 |
| Bobeica, SC; van der Donk, WA | 1 |
| Schey, KL; Wang, Z | 1 |
| Brindisi, M; Ghosh, AK; Ghosh, K; Huang, X; Kumaragurubaran, N; Lendy, EK; Mesecar, AD; Tang, J; Yen, YC | 1 |
| Hamad, M; Monjarás Feria, J; Ruan, X; Valvano, MA | 1 |
| Bottecchia, C; Noël, T | 1 |
| Chen, H; Feng, Z; Leng, C; Liu, G; Lv, X; Qiao, Y; Sun, J; Zhang, Y | 1 |
| Clerici, M; Growkova, K; Komander, D; Morgan, MT; Morrow, ME; Simicek, M; Sixma, TK; Wolberger, C; Yan, M | 1 |
| Funaki, R; Igarashi, K; Komatsu, T; Morita, Y | 1 |
| Cabrales, P; Carlström, M; Isbell, TS; Kim-Shapiro, DB; Kleschyov, AL; Lundberg, JO; Oh, JY; Patel, RP; Pernow, J; Sun, CW; Townes, T; Tsai, AG; Wajih, N; Yang, J; Zhuge, Z | 1 |
| Balakrishna, AM; Eisenhaber, B; Eisenhaber, F; Grüber, A; Grüber, G; Kamariah, N; Shin, J; Toh, YK | 1 |
| Liu, H; Nash, MA; Schittny, V | 1 |
| Mothersole, RG; Wolthers, KR | 1 |
| Du, W; Gao, C | 1 |
| Ahn, YH; Huang, B; VanHecke, GC; Yapa Abeywardana, M | 1 |
| Alessandri, C; Brandstetter, H; Gadermaier, G; Griessner, I; Huber, CG; Mari, A; Regl, C; Soh, WT; Stemeseder, T; Stock, LG; Stutz, H; Völker, T; Wildner, S | 1 |
| Galsgaard, KD; Holst, JJ; Jepsen, SL; Kjeldsen, SAS; Pedersen, J; Wewer Albrechtsen, NJ | 1 |
| Cheng, B; Li, T | 1 |
| Himeno, S; Ogawa, M; Okamoto, Y; Sumi, D; Suzukawa, K | 1 |
| Fernández-García, C; Foden, CS; Islam, S; Maugeri, L; Powner, MW; Sheppard, TD | 1 |
| Michaelis, S; Mossberg, OW; Odinammadu, KO; Spear, ED; Wood, KM; Xu, W | 1 |
| Papanikolopoulou, K; Prifti, E; Samiotaki, M; Stamatakis, G; Tsakiri, EN; Vourkou, E | 1 |
| Badepally, NG; Singh, A; Surolia, A | 1 |
| Leeuwon, SZ; Liu, WR; Qiao, Y; Yu, G | 1 |
| Addo, MA; Dos Santos, PC; Edwards, AM | 1 |
| De Luca, S; Digilio, G; Saviano, M; Verdoliva, V | 1 |
| Becker, K; Bernhagen, J; Bourilhon, P; Hahn, J; Przyborski, JM; Rahlfs, S; Schipper, S; Springer, E | 1 |
| Bell, AG; Benavides, I; Deming, TJ; Evans, D; Houk, KN; Raftery, ED; Scott, WA | 1 |
| Chen, H; Pan, H; Ren, F; Ren, P; Wang, W | 1 |
| Anjum Zia, M; Jahan, N; Kiran, S; Mujtaba, N; Naqvi, SAR; Sultana, B | 1 |
| Abe, K; Hidaka, M; Kunii, K; Kurono, K; Miyamoto, A; Nanatani, K; Ogasawara, S; Suzuki, S; Yamanaka, T; Yoshimi, A | 1 |
| Gugkaeva, ZT; Larionov, VA; Maleev, VI; Mardiyan, ZZ; Poghosyan, AS; Saghyan, AS; Smol'yakov, AF | 1 |
| Chen, X; Ge, T; He, Z; Wang, J; Yuan, H; Zhang, L | 1 |
| Li, Z; Luo, Y; Ren, W; Teng, Y; Wang, H; Zhao, R | 1 |
| Homma, H; Katane, M; Miyamoto, T; Saitoh, Y; Sakai-Kato, K; Sekine, M | 1 |
| Bacchella, C; Casella, L; Dell'Acqua, S; Gentili, S; Monzani, E; Mozzi, SI; Tegoni, M | 1 |
| Abe, K; Chiba, F; Kimura, T; Kon, N; Nanatani, K; Suzuki, S | 1 |
| Ji, G; Luo, B; Shen, G; Tian, T | 1 |
| Cui, Y; Feng, C; Gao, H; Li, D; Mao, H; Wang, C; Wei, X; Yang, J; Zhu, J | 1 |
| Cui, H; Hayat, K; Ho, CT; Xia, X; Zhang, X; Zhou, T | 1 |
| Endo, K; Kitamura, H; Makabe, H; Sawa, T; Tanaka, S; Umezawa, K | 1 |
| Cui, H; Hayat, K; Ho, CT; Xia, X; Zhai, Y; Zhang, F; Zhang, X; Zhou, T | 1 |
| Karakirova, Y | 1 |
| Chen, M; Chen, ZS; Deng, R; Huang, J; Huang, M; Liu, R; Lyu, W; Miao, Q; Qi, M; Qi, Q; Wang, C; Wen, Q; Wu, C; Xie, J; Ye, W; Zhang, D; Zhang, J; Zhang, Z | 1 |
| Buncherd, H; Chokchaichamnankit, D; Eurtivong, C; Mongkolsuk, S; Nontaleerak, B; Srisomsap, C; Sukchawalit, R; Svasti, J; Weeraphan, C | 1 |
| Cheng, B; Li, W; Ling, Z; Lu, J; Su, Z; Tao, X; Wang, J; Yang, X | 1 |
| Li, Z; Liang, L; Yan, W; Zhang, J; Zhang, Q; Zhang, Y; Zuo, M | 1 |
| Ghiabi, P; Green, SR; Santhakumar, V; Vedadi, M; Yong, D | 1 |
| Akamatsu, M; Asao, M; Fujita, T; Iwamura, H | 1 |
| Dean, KE; Klein, G; Renaudet, O; Reymond, JL | 1 |
11 review(s) available for alanine and cysteine
| Article | Year |
|---|---|
[Aliphatic alpha-amino acids as biologically active compounds].
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cysteine; Glutamates; Glutamic Acid; Glycine; Homeostasis; Humans | 1990 |
Selective cleavage and modification of peptides and proteins.
Topics: Alanine; Aspartic Acid; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Glutamates; Glycine; Hydrogen-Ion Concentration; Methionine; Muramidase; Oxidation-Reduction; Peptides; Phenylalanine; Proline; Proteins; Pyrrolidines; Ribonucleases; Serine; Succinates; Threonine; Tryptophan | 1970 |
[Multiple sulfatase deficiency].
Topics: Alanine; Aldehydes; Brain; Cysteine; Humans; Kidney; Leukodystrophy, Metachromatic; Sulfatases; Sulfoglycosphingolipids | 1998 |
Back to Camelot: defining the specific role of tRNA in protein synthesis.
Topics: Alanine; Alleles; Cysteine; Escherichia coli; Genetic Code; Hemoglobins; History, 20th Century; Models, Biological; Molecular Biology; Protein Biosynthesis; RNA, Transfer | 1999 |
Marfey's reagent for chiral amino acid analysis: a review.
Topics: Alanine; Amines; Amino Acids; Animals; Bacteria; Biochemistry; Body Fluids; Cysteine; Dinitrobenzenes; Humans; Peptides; Stereoisomerism | 2004 |
Structure-activity relationships of urotensin II and URP.
Topics: Alanine; Amino Acid Sequence; Animals; Cysteine; Disulfides; Humans; Molecular Sequence Data; Molecular Structure; Peptide Fragments; Peptide Hormones; Protein Conformation; Sequence Alignment; Structure-Activity Relationship; Tyrosine; Urotensins | 2008 |
MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk and disease progression: a meta-analysis.
Topics: Alanine; Amino Acid Substitution; Carcinoma; Case-Control Studies; Cysteine; Disease Progression; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors; Threonine; Urinary Bladder Neoplasms | 2013 |
Insights into the evolution of lanthipeptide biosynthesis.
Topics: Alanine; Amino Acids; Bacterial Proteins; Cyclization; Cysteine; Evolution, Molecular; Hydro-Lyases; Multienzyme Complexes; Peptides, Cyclic; Protein Processing, Post-Translational; Serine; Sulfides; Threonine | 2013 |
Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.
Topics: Alanine; Animals; Binding Sites; Biotechnology; Catalysis; Catalytic Domain; Cysteine; Glycine; Humans; Models, Molecular; Protein Processing, Post-Translational; Serine; Sulfotransferases | 2015 |
Lack of association between MTHFR A1298C variant and Alzheimer's disease: evidence from a systematic review and cumulative meta-analysis.
Topics: Alanine; Alzheimer Disease; Cysteine; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2017 |
Photocatalytic Modification of Amino Acids, Peptides, and Proteins.
Topics: Alanine; Amino Acids; Catalysis; Cysteine; Light; Methionine; Oxidation-Reduction; Peptides; Proteins; Tryptophan | 2019 |
3 trial(s) available for alanine and cysteine
| Article | Year |
|---|---|
Daily rhythms in the concentrations of various amino acids in human plasma.
Topics: Adolescent; Adult; Alanine; Amino Acids; Circadian Rhythm; Cysteine; Dietary Proteins; Glutamates; Glycine; Humans; Isoleucine; Male; Methionine; Phenylalanine; Tryptophan; Tyrosine | 1968 |
Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study.
Topics: Adult; Alanine; Azathioprine; Crohn Disease; Cysteine; Female; Humans; Inosine Triphosphatase; Male; Methyltransferases; Patient Dropouts; Prospective Studies; Pyrophosphatases | 2005 |
Effects of randomized supplementation of methionine or alanine on cysteine and glutathione production during the early phase of treatment of children with edematous malnutrition.
Topics: Alanine; Cysteine; Diet; Dietary Supplements; Erythrocytes; Glutathione; Humans; Infant; Isotopes; Kwashiorkor; Methionine; Up-Regulation | 2014 |
947 other study(ies) available for alanine and cysteine
| Article | Year |
|---|---|
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Topics: Amino Acid Transport Systems; Caco-2 Cells; Endocytosis; Humans; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters | 2011 |
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2022 |
On the specific cleavage of cysteine containing peptides and proteins.
Topics: Alanine; Amino Acids; Chemical Phenomena; Chemistry; Cysteine; Glutathione; Hydrogen-Ion Concentration; Hydrolysis; Molecular Weight; Peptides; Proteins | 1977 |
Lysinoalanine formation in protein food ingredients.
Topics: Alanine; Chemical Phenomena; Chemistry; Cysteine; Dietary Proteins; Disulfides; Food Handling; Hydrogen-Ion Concentration; Kinetics; Lysine | 1977 |
[Inhibiting effects of anti-proteinase agents upon induced ovulation].
Topics: Alanine; Animals; Chorionic Gonadotropin; Citrates; Cysteine; Edetic Acid; Female; Glutamates; Gonadotropins, Equine; Humans; Hydrochloric Acid; Microbial Collagenase; Ovary; Ovulation; Oxalates; Rats; Superovulation | 1975 |
Effects of diaminopropionate, deoxyadenosine, and theophylline on stimulated formation of cyclic AMP and GMP by depolarizing agents in slices of guinea-pig cerebral cortex.
Topics: Adenosine; Alanine; Amino Acids, Diamino; Animals; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Cysteine; Deoxyadenosines; Glutamates; Guinea Pigs; Histamine; In Vitro Techniques; Male; Nucleotides, Cyclic; Ouabain; Potassium; Theophylline; Veratridine; Xanthines | 1977 |
Influence of amino acids on the activity of cellulolytic enzymes obtained from spent medium of Fusarium cultures and on the "Cellulase S" Novo.
Topics: Alanine; Amino Acids; Cellulase; Cysteine; Cystine; Fusarium; Glycoside Hydrolases; Hydrogen-Ion Concentration; Methionine; Temperature; Time Factors | 1975 |
Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions.
Topics: Alanine; Amino Acyl-tRNA Synthetases; Cysteine; Escherichia coli; Kinetics; Protein Binding; Serine; Substrate Specificity | 1979 |
Gamma heavy chain disease: clinical aspects and characterization of a deleted, noncovalently linked gamma1 heavy chain dimer (BAZ).
Topics: Aged; Alanine; Cysteine; Female; Glycine; Heavy Chain Disease; Humans; Immunoglobulin G; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Molecular Weight; Peptide Termination Factors; Plasma Cells; Submandibular Gland | 1977 |
Sodium-dependent cysteine transport in human red blood cells.
Topics: Alanine; Biological Transport, Active; Cations, Monovalent; Choline; Cysteine; Erythrocytes; Humans; In Vitro Techniques; Sodium | 1979 |
Gas-liquid chromatography and mass spectrometry of lanthionine, lysinoalanine, and S-carboxyethylcysteine.
Topics: Alanine; Animals; Chromatography, Gas; Cysteine; Keratins; Lysine; Mass Spectrometry; Wool | 1977 |
Stereochemistry of the beta-cyanoalanine synthetase and S-alkylcysteine lyase reactions.
Topics: Alanine; Cysteine; Isotope Labeling; Lyases; Malates; Stereoisomerism; Tritium | 1978 |
Sodium-dependent amino acid transport in human erythrocytes [proceedings].
Topics: Alanine; Biological Transport; Cysteine; Erythrocytes; Humans; Sodium | 1978 |
Comparison of transport at the anterior and posterior surfaces of the calf lens.
Topics: Alanine; Amino Acids; Animals; Arginine; Biological Transport; Cattle; Cysteine; Epithelium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kinetics; Lens, Crystalline; Leucine; Serine | 1977 |
On the origin of the cyanolysable sulphur in molybdenum iron/sulphur flavin hydroxylases.
Topics: Alanine; Aldehyde Oxidoreductases; Arsenic; Binding Sites; Chemical Phenomena; Chemistry; Cyanides; Cysteine; Iron-Sulfur Proteins; Ketone Oxidoreductases; Metalloproteins; Molybdenum; Sulfides; Sulfur; Xanthine Dehydrogenase; Xanthine Oxidase | 1977 |
alpha, beta-Unsaturated and related amino acids in peptides and proteins.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Cysteine; Disulfides; Nisin; Peptides; Proteins; Subtilisins | 1977 |
Regional uptake of neurotoxic and nontoxic amino acids in vivo by the infant mouse brain.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Brain; Cysteine; Glutamates; Hypothalamus; Male; Mice; Neurons; Thalamus; Time Factors | 1976 |
Stereochemistry of the reaction of sheep liver threonine dehydratase. A nuclear magnetic resonance and optical rotatory dispersion study of its reaction pathway and products.
Topics: Alanine; Animals; Butyrates; Cysteine; Hydro-Lyases; Keto Acids; Liver; Magnetic Resonance Spectroscopy; Optical Rotatory Dispersion; Propionates; Serine; Sheep; Stereoisomerism; Threonine; Threonine Dehydratase | 1976 |
Control mechanisms of oxygen and glucose utilization in tumours.
Topics: Alanine; Animals; Carcinoma, Ehrlich Tumor; Cysteine; Glucose; Glycolysis; Kinetics; Mitochondria; Models, Biological; Oxygen Consumption; Phenylalanine; Phosphoenolpyruvate; Pyruvate Kinase; Pyruvates; Uncoupling Agents | 1976 |
Specific cyanylation and cleavage at cysteine-104 human hemoglobin alpha-chain. A novel approach to the problem of the alpha-chain tryptic core in the study of haemoglobin variants by "fingerprinting" methods.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Cyanides; Cysteine; Hemoglobins; Hemoglobins, Abnormal; Histidine; Humans; Hydrolysis; Pepsin A; Peptide Fragments; Protein Conformation; Trypsin | 1975 |
Methionine hydroxy analog supplementation of low protein calf rations.
Topics: Alanine; Amino Acids, Essential; Animal Feed; Animals; Body Weight; Cattle; Cysteine; Dietary Proteins; Female; Lysine; Male; Methionine; Milk; Nutritional Requirements; Phenylalanine | 1975 |
Membrane transport in Schistosoma mansoni: transport of amino acids by adult males.
Topics: Alanine; Amino Acids; Animals; Arginine; Biological Transport; Chromatography; Cysteine; Female; Glutamates; Glycine; Kinetics; Male; Methionine; Mice; Proline; Schistosoma mansoni; Tryptophan | 1975 |
[Some indices of nitrogen metabolism in patients with viral hepatitis].
Topics: Adolescent; Adult; Alanine; Ammonia; Asparagine; Chronic Disease; Cysteine; Cystinuria; Glutamates; Glycine; Hepatitis A; Humans; Isoleucine; Leucine; Methionine; Middle Aged; Nitrogen; Phenylalanine; Serine; Threonine; Urea; Valine | 1975 |
[Free amino acids in the amniotic fluid and in maternal blood in advanced pregnancy].
Topics: Alanine; Amino Acids; Amniotic Fluid; Cysteine; Female; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Pregnancy Trimester, Third; Proline; Serine; Threonine; Tyrosine; Valine | 1975 |
Nutrition of Vitreoscilla stercoraria.
Topics: Alanine; Amino Acids; Aspartic Acid; Cysteine; Glutamates; Glutamine; Proline; Serine; Thiotrichaceae | 1975 |
Relative reactivities of sulfhydryl groups with N-acetyl dehydroalanine and N-acetyl dehydroalanine methyl ester.
Topics: Alanine; Chemical Phenomena; Chemistry; Cysteine; Esters; Magnetic Resonance Spectroscopy; Penicillamine; Sulfhydryl Compounds; Temperature; Time Factors | 1976 |
Studies on trypsin inhibitors. Part I. Synthesis of protected peptides related to sequence 1-10 of porcine pancreatic secretory trypsin inhibitor II (Kazal).
Topics: Alanine; Animals; Arginine; Cysteine; Glutamine; Peptides; Proline; Serine; Swine; Threonine; Trypsin Inhibitor, Kazal Pancreatic; Trypsin Inhibitors; Valine | 1976 |
[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part I: Changes in concentration in normal pregnancy (author's transl)].
Topics: Alanine; Amino Acids; Amniotic Fluid; Chromatography, Gas; Cysteine; Female; Gestational Age; Glycine; Humans; Hydroxyproline; Methionine; Ornithine; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1976 |
Amino acid transport in normal and glutathione-deficient sheep erythrocytes.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Biological Transport; Cysteine; Erythrocytes; Glutathione; In Vitro Techniques; Kinetics; Lysine; Sheep; Sodium; Temperature; Time Factors | 1976 |
Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet.
Topics: Alanine; alpha-Macroglobulins; Animals; Ceruloplasmin; Cysteine; Dietary Proteins; Eating; Food, Fortified; Glutathione; Glycine; Kidney; Liver; Male; Organ Size; Orosomucoid; Proteins; Rats; Rats, Wistar; Recombinant Proteins; Tumor Necrosis Factor-alpha; Zinc | 1992 |
His92Ala mutation in ribonuclease T1 induces segmental flexibility. An X-ray study.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Sequence; Catalysis; Cysteine; Guanine; Guanosine Monophosphate; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Ribonuclease T1; Structure-Activity Relationship; Temperature; Valine; X-Ray Diffraction | 1992 |
Serine residues responsible for tetracycline transport are on a vertical stripe including Asp-84 on one side of transmembrane helix 3 in transposon Tn10-encoded tetracycline/H+ antiporter of Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Antiporters; Aspartic Acid; Bacterial Proteins; Base Sequence; Biological Transport; Carrier Proteins; Cell Membrane; Cysteine; DNA Transposable Elements; DNA, Bacterial; Escherichia coli; Immunoblotting; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Repressor Proteins; Serine; Tetracycline; Threonine | 1992 |
The substitution of cysteine 17 of recombinant human G-CSF with alanine greatly enhanced its stability.
Topics: Alanine; Animals; Bone Marrow Cells; Cysteine; Female; Granulocyte Colony-Stimulating Factor; Hot Temperature; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Recombinant Proteins; Structure-Activity Relationship | 1992 |
Disulfide bond-coupled folding of bovine pancreatic trypsin inhibitor derivatives missing one or two disulfide bonds.
Topics: Alanine; Alkylation; Aprotinin; Cysteine; Disulfides; Dithiothreitol; Glutathione; Kinetics; Mass Spectrometry; Oxidation-Reduction; Protein Conformation | 1992 |
Cys residues of the hepatitis B virus capsid protein are not essential for the assembly of viral core particles but can influence their stability.
Topics: Alanine; Base Sequence; Capsid; Cysteine; Endopeptidases; Hepatitis B virus; Macromolecular Substances; Molecular Sequence Data; Structure-Activity Relationship; Substrate Specificity; Virus Replication | 1992 |
C-terminal cysteines of Tn501 mercuric ion reductase.
Topics: Alanine; Base Sequence; Binding Sites; Catalysis; Cysteine; Escherichia coli; Kinetics; Mercuric Chloride; Mercury; Molecular Sequence Data; Mutagenesis, Site-Directed; Niacinamide; Oxidation-Reduction; Oxidoreductases; Phenotype; Spectrophotometry; Structure-Activity Relationship; Sulfhydryl Compounds; Transformation, Bacterial | 1992 |
Serine-376 contributes to the binding of substrate by ribulose-bisphosphate carboxylase/oxygenase from Anacystis nidulans.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Cyanobacteria; Cysteine; Enzyme Activation; Kinetics; Mutagenesis, Site-Directed; Protein Binding; Ribulose-Bisphosphate Carboxylase; Serine; Substrate Specificity; Threonine | 1992 |
Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Chloramphenicol O-Acetyltransferase; CHO Cells; Cricetinae; Cysteine; Estradiol; Humans; Kinetics; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Receptors, Estrogen; Recombinant Fusion Proteins; TATA Box; Temperature; Transcription, Genetic; Transcriptional Activation; Transfection | 1992 |
Stable ester conjugate between the Saccharomyces cerevisiae RAD6 protein and ubiquitin has no biological activity.
Topics: Alanine; Base Sequence; Cysteine; Deoxyribonucleotides; DNA Repair; DNA, Fungal; Esters; Fungal Proteins; Immunoblotting; Ligases; Molecular Sequence Data; Mutagenesis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin-Conjugating Enzymes; Ubiquitins | 1991 |
Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones.
Topics: Alanine; Arginine; Biological Transport; Cell Division; Cell Membrane; Cells, Cultured; Clone Cells; Cysteine; Cystine; Glutamates; Glutamic Acid; HIV Seropositivity; Humans; Lymphocytes; Methionine; Mitogens; Phytohemagglutinins; T-Lymphocytes | 1991 |
Role of an evolutionarily invariant serine for the stability of human carbonic anhydrase II.
Topics: Alanine; Binding Sites; Biological Evolution; Carbonic Anhydrases; Cysteine; Erythrocytes; Humans; Mutation; Protein Conformation; Serine | 1992 |
Immunogenic peptides corresponding to the dominant antigenic region alanine-597 to cysteine-619 in the transmembrane protein of simian immunodeficiency virus have a propensity to fold in aqueous solution.
Topics: Alanine; Amino Acid Sequence; Animals; Antibody Specificity; Cross Reactions; Cysteine; Humans; Immunodominant Epitopes; Macaca; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Rabbits; Simian Immunodeficiency Virus; Solutions; Viral Envelope Proteins | 1992 |
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.
Topics: Acetylcholinesterase; Alanine; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cysteine; Disulfides; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Plasmids; Protein Denaturation; Recombinant Proteins; Restriction Mapping; Thermodynamics; Transfection | 1991 |
Impaired alanine uptake by basolateral liver plasma membrane vesicles from rats consuming ethanol.
Topics: Alanine; Alcohol Drinking; Animals; Biological Transport; Cell Membrane; Cholesterol; Cysteine; Liver; Male; Membrane Fluidity; Rats; Rats, Inbred Strains; Sodium | 1991 |
Formation of a dehydroalanyl residue from S-benzylcysteine upon HF cleavage of a [Sar1, Cys8]-angiotensin II peptide resin.
Topics: Alanine; Cysteine; Hydrofluoric Acid; Magnetic Resonance Spectroscopy; Molecular Structure; Resins, Synthetic | 1991 |
Isolation method for lysine-excreting mutants of Arthrobacter globiformis.
Topics: Alanine; Arthrobacter; Bacteriological Techniques; Cysteine; Drug Resistance, Microbial; Lysine; Methylnitronitrosoguanidine; Mutation | 1991 |
The conserved, buried aspartic acid in oxidized Escherichia coli thioredoxin has a pKa of 7.5. Its titration produces a related shift in global stability.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Binding Sites; Buffers; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Proline; Protein Conformation; Sulfhydryl Compounds; Thioredoxins | 1991 |
L-alanine transport in isolated cells of interscapular brown adipose tissue in rat.
Topics: Adipose Tissue, Brown; Alanine; Aminoisobutyric Acids; Animals; Biological Transport, Active; Cysteine; Female; Glutamine; Kinetics; Leucine; Potassium; Rats; Rats, Inbred Strains; Scapula; Sodium | 1991 |
Two-dimensional magnetization exchange spectroscopy of Anabaena 7120 ferredoxin. Nuclear Overhauser effect and electron self-exchange cross peaks from amino acid residues surrounding the 2Fe-2S* cluster.
Topics: Alanine; Arginine; Binding Sites; Cyanobacteria; Cysteine; Ferredoxins; Iron; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Oxidation-Reduction; Spectrum Analysis; Sulfur | 1991 |
Analysis of neutral amino acid transport systems in the small intestine: a study of brush border membrane vesicles.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Culture Media; Cysteine; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Microvilli; Proline; Serine | 1991 |
Direct analysis of the disulfide content of proteins: methods for monitoring the stability and refolding process of cystine-containing proteins.
Topics: Alanine; Amino Acids; Animals; Chromatography, High Pressure Liquid; Cysteine; Cystine; Diazonium Compounds; Drug Stability; Humans; Lysinoalanine; Protein Conformation; Proteins; Reproducibility of Results; Sensitivity and Specificity; Sulfanilic Acids; Sulfides | 1991 |
Directed mutagenesis of the redox-active disulphide bridge in glutathione reductase from Escherichia coli.
Topics: Alanine; Base Sequence; Binding Sites; Cysteine; Disulfides; Escherichia coli; Glutathione Reductase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Oxidation-Reduction; Plasmids; Spectrophotometry | 1990 |
A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.
Topics: Alanine; Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Circular Dichroism; Cysteine; Fluorescence; Genetic Variation; Growth Hormone; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Somatotropin; Tryptophan; Tyrosine | 1991 |
The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast.
Topics: Alanine; Crystallization; Cysteine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Genes, Fungal; Hot Temperature; Humans; Models, Molecular; Muramidase; Mutation; Protein Conformation; Saccharomyces cerevisiae; X-Ray Diffraction | 1991 |
Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.
Topics: Alanine; Alleles; Cysteine; DNA Repair; Dose-Response Relationship, Radiation; Genes, Fungal; Genotype; Ligases; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin-Conjugating Enzymes; Ubiquitins; Ultraviolet Rays; Valine | 1990 |
Reversible import of apocytochrome c into mitochondria.
Topics: Alanine; Animals; Apoproteins; Biological Transport; Cysteine; Cytochrome c Group; Cytochromes c; Drosophila melanogaster; Kinetics; Mice; Mice, Inbred ICR; Mitochondria, Liver; Mutation; Protein Binding; Protein Biosynthesis; Serine; Transcription, Genetic | 1990 |
Kinetic evidence for the formation of D-alanyl phosphate in the mechanism of D-alanyl-D-alanine ligase.
Topics: Adenosine Triphosphate; Alanine; Aniline Compounds; Cysteine; Kinetics; Oxygen Isotopes; Peptide Synthases; Phosphates; Phosphorylation; Salmonella typhimurium; Sulfhydryl Compounds | 1990 |
Effects of amino acids on acute alcohol intoxication in mice--concentrations of ethanol, acetaldehyde, acetate and acetone in blood and tissues.
Topics: Acetaldehyde; Acetates; Acetone; Alanine; Alcoholic Intoxication; Amino Acids; Animals; Cysteine; Ethanol; Male; Mice; Mice, Inbred ICR | 1990 |
A conserved cleavage-site motif in chloroplast transit peptides.
Topics: Alanine; Amino Acid Sequence; Arginine; Carrier Proteins; Chloroplasts; Cysteine; Isoleucine; Molecular Sequence Data; Plant Proteins; Valine | 1990 |
Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.
Topics: ADP Ribose Transferases; Alanine; Animals; Antineoplastic Agents; Bacterial Toxins; Cell Line; Cloning, Molecular; Cysteine; ErbB Receptors; Exotoxins; Female; Humans; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Neoplasms; Pseudomonas aeruginosa Exotoxin A; Recombinant Fusion Proteins; Transforming Growth Factor alpha; Transforming Growth Factors; Virulence Factors | 1990 |
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.
Topics: Alanine; Amino Acid Sequence; Animals; Calorimetry, Differential Scanning; Cattle; Crystallization; Cysteine; Enzyme Stability; Hot Temperature; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Superoxide Dismutase; X-Ray Diffraction | 1990 |
Sodium-dependent neutral amino acid transport by human liver plasma membrane vesicles.
Topics: Adult; Alanine; Amino Acids; Aminoisobutyric Acids; Biological Transport; Cell Membrane; Cysteine; Glutamine; Histidine; Humans; Kinetics; Liver; Sodium | 1990 |
Reaction mechanism of Escherichia coli cystathionine gamma-synthase: direct evidence for a pyridoxamine derivative of vinylglyoxylate as a key intermediate in pyridoxal phosphate dependent gamma-elimination and gamma-replacement reactions.
Topics: Alanine; Allylglycine; Carbon-Oxygen Lyases; Cysteine; Escherichia coli; Fatty Acids, Monounsaturated; Homoserine; Kinetics; Lyases; Molecular Structure; Pyridoxal Phosphate; Pyridoxamine; Spectrophotometry; Spectrophotometry, Ultraviolet | 1990 |
Some observations on the replacement of the conserved amino acid residues of immunoglobulin domains.
Topics: Alanine; Amino Acids; beta 2-Microglobulin; Computer Graphics; Cysteine; Immunoglobulin Constant Regions; Immunoglobulin Variable Region; Immunoglobulins; Leucine; Serine; Tryptophan; Tyrosine | 1989 |
The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity.
Topics: Alanine; Amidophosphoribosyltransferase; Amino Acid Sequence; Aspartate-Ammonia Ligase; Bacillus subtilis; Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Glutamine; Humans; Ligases; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Plasmids; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid | 1989 |
A theoretical study of glucosamine synthase. Part I. Molecular mechanics calculations on substrate binding.
Topics: Alanine; Amino Acid Sequence; Cysteine; Fructosephosphates; Glutamate-Ammonia Ligase; Hydrogen Bonding; Mathematics; Models, Theoretical; Molecular Sequence Data; Protein Binding; Protein Conformation | 1989 |
Immunochemistry of the dominating antigenic region Ala582 to Cys604 in the transmembranous protein of simian and human immunodeficiency virus.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, Surface; Binding, Competitive; Cross Reactions; Cysteine; HIV Antibodies; HIV Antigens; HIV Infections; Humans; Immunohistochemistry; Macaca mulatta; Membrane Proteins; Mice; Molecular Sequence Data; Peptides; Rabbits; Simian Immunodeficiency Virus | 1989 |
Azidoalanine mutagenicity in Salmonella: effect of homologation and alpha-methyl substitution.
Topics: Acetates; Alanine; Azides; Chemical Phenomena; Chemistry; Citric Acid Cycle; Cysteine; Methylation; Mutagenicity Tests; Salmonella typhimurium; Structure-Activity Relationship | 1989 |
High-performance liquid chromatography of cystathionine, lanthionine and aminoethylcysteine using o-phthaldialdehyde precolumn derivatization.
Topics: Alanine; Chromatography, High Pressure Liquid; Cystathionine; Cysteine; Indicators and Reagents; o-Phthalaldehyde; Sulfides | 1989 |
Determination of cysteinesulfinate, hypotaurine and taurine in physiological samples by reversed-phase high-performance liquid chromatography.
Topics: Alanine; Aminobutyrates; Animals; Chromatography, High Pressure Liquid; Cysteine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Liver; Male; Neurotransmitter Agents; o-Phthalaldehyde; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Taurine | 1985 |
Alanine transport systems in isolated basal plasma membrane of human placenta.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Biological Transport; Cell Membrane; Cysteine; Dihydroalprenolol; Female; Humans; Kinetics; Maternal-Fetal Exchange; Placenta; Pregnancy | 1989 |
Effects of ethanol on amino acid transport in basolateral liver plasma membrane vesicles.
Topics: Alanine; Animals; Biological Transport; Cell Membrane; Cysteine; Ethanol; Kinetics; Leucine; Liver; Membrane Fluidity; Potassium; Quaternary Ammonium Compounds; Rats; Sodium | 1989 |
Role of cysteine residues in glutathione synthetase from Escherichia coli B. Chemical modification and oligonucleotide site-directed mutagenesis.
Topics: Alanine; Amino Acids; Chemical Phenomena; Chemistry; Chloromercuribenzoates; Codon; Cysteine; Dithionitrobenzoic Acid; Escherichia coli; Ethylmaleimide; Genes, Bacterial; Glutathione Synthase; Mutation; p-Chloromercuribenzoic Acid; Peptide Synthases; Plasmids; Sulfhydryl Compounds; Thiocyanates; Transformation, Bacterial | 1988 |
Functional sites of the Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions.
Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Chromatography, High Pressure Liquid; Cysteine; DNA Repair; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation; Methylation; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors; Transcription, Genetic | 1988 |
Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase.
Topics: Alanine; Binding, Competitive; Catalysis; Cysteine; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Lyases; Oxindoles; Pyridoxal Phosphate; Solvents; Tryptophan; Tryptophanase | 1988 |
Substitutions in the active site of chloramphenicol acetyltransferase: role of a conserved aspartate.
Topics: Alanine; Arginine; Asparagine; Aspartic Acid; Binding Sites; Chloramphenicol; Chloramphenicol O-Acetyltransferase; Cysteine; Drug Stability; Escherichia coli; Histidine; Hot Temperature; Hydrogen Bonding; Kinetics; Mutation; Structure-Activity Relationship; Sulfhydryl Reagents | 1988 |
Neutral amino acid transport in mouse peritoneal macrophages.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Cells, Cultured; Cysteine; Kinetics; Leucine; Macrophages; Male; Mice; Mice, Inbred C57BL; Serine; Tritium | 1987 |
Evidence for an alanine, serine, and cysteine system of transport in isolated brain capillaries.
Topics: Alanine; Animals; Biological Transport; Capillaries; Cerebrovascular Circulation; Cysteine; Female; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Serine; Sodium | 1987 |
Influence of natural and recombinant interleukin 2 on endothelial cell arachidonate metabolism. Induction of de novo synthesis of prostaglandin H synthase.
Topics: 6-Ketoprostaglandin F1 alpha; Alanine; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Chromatography, High Pressure Liquid; Cycloheximide; Cysteine; Dactinomycin; Endothelium, Vascular; Enzyme Induction; Epoprostenol; Humans; Interleukin-2; Molecular Weight; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Serine; Structure-Activity Relationship; Tissue Plasminogen Activator; von Willebrand Factor | 1988 |
Mechanism of reactions catalyzed by selenocysteine beta-lyase.
Topics: Alanine; Animals; Binding Sites; Cysteine; In Vitro Techniques; Keto Acids; Liver; Lyases; Pyridoxamine; Selenium; Selenocysteine; Swine | 1985 |
Mechanistic deductions from kinetic isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Erwinia herbicola and Citrobacter freundii tyrosine phenol-lyase.
Topics: Alanine; Binding, Competitive; Citrobacter; Cysteine; Deuterium; Erwinia; Hydrogen-Ion Concentration; Kinetics; Lyases; Phenylalanine; Pyridoxal Phosphate; Tyrosine; Tyrosine Phenol-Lyase | 1988 |
Role of disulfide bridges in determining the biological activity of interleukin 3.
Topics: Alanine; Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Disulfides; DNA; Humans; Interleukin-3; Molecular Sequence Data; Peptide Mapping; Structure-Activity Relationship | 1988 |
Neutral amino acid transport systems of microvillous membrane of human placenta.
Topics: Alanine; Amino Acids; Aminobutyrates; Biological Transport, Active; Cysteine; Female; Humans; Leucine; Microvilli; Placenta; Pregnancy; Sodium; Tryptophan | 1988 |
Recombinant DNA-derived forms of human alpha 1-proteinase inhibitor. Studies on the alanine 358 and cysteine 358 substituted mutants.
Topics: Alanine; alpha 1-Antitrypsin; Blood Proteins; Chemical Phenomena; Chemistry; Cysteine; Dithiothreitol; DNA, Recombinant; Endopeptidases; Humans; Kinetics; Macromolecular Substances; Mutation; Neutrophils; Pancreas; Pancreatic Elastase; Saccharomyces cerevisiae; Serine Endopeptidases; Structure-Activity Relationship | 1986 |
A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase.
Topics: Alanine; Alkylation; Amino Acid Sequence; Amino Acyl-tRNA Synthetases; Binding Sites; Cysteine; Escherichia coli; Ethylmaleimide; Glutamine; Glycine-tRNA Ligase; Kinetics; Mutation | 1986 |
Involvement of nucleophiles in the inactivation of atracurium.
Topics: Alanine; Animals; Atracurium; Cysteine; Inactivation, Metabolic; Neuromuscular Blocking Agents; Propionates; Rats; Tubocurarine | 1987 |
The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase.
Topics: Alanine; Amino Acids; Animals; Cattle; Cystathionine; Cysteine; Cystine; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Hydrogen-Ion Concentration; Kidney; Kinetics; Molecular Weight; Rats; Species Specificity; Structure-Activity Relationship; Substrate Specificity; Sulfides; Transaminases | 1986 |
Synthesis and uptake of taurine by isolated human granulocytes.
Topics: Adult; Alanine; Binding, Competitive; Biological Transport; Cysteine; Granulocytes; Humans; Sodium; Taurine; Temperature | 1986 |
Biosynthesis of valanimycin.
Topics: Alanine; Anti-Bacterial Agents; Azo Compounds; Carbon Radioisotopes; Cysteine; Leucine; Magnesium; Streptomyces; Tritium; Valine | 1986 |
Synthesis and expression of a human growth hormone (somatotropin) gene mutated to change cysteine-165 to alanine.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Codon; Cysteine; Escherichia coli; Genes; Growth Hormone; Humans; Mutation; Oligodeoxyribonucleotides; Plasmids | 1985 |
Hapten-specific prophylaxis of murine contact sensitivity by DNP-amino acid derivatives.
Topics: Alanine; Amino Acids; Animals; Cell Division; Cysteine; Dermatitis, Contact; Dinitrofluorobenzene; Dinitrophenols; Female; Glycine; Haptens; Immunization, Passive; Lymph Nodes; Lysine; Mice; Mice, Inbred BALB C; Spleen | 1985 |
Inhibition of germinant binding by bacterial spores in acidic environments.
Topics: Alanine; Bacillus cereus; Clostridium botulinum; Cysteine; Hydrogen-Ion Concentration; Spores, Bacterial; Time Factors | 1985 |
A new Na+-independent transport system for dipolar amino acids apparently corresponding to systems persisting after erythrocyte maturation in some mammalian genotypes.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Columbidae; Cysteine; Erythrocyte Aging; Erythrocytes; Horses; Kinetics; Serine; Sheep; Sodium; Species Specificity; Threonine | 1985 |
Characterization of a novel Na+-independent amino acid transporter in horse erythrocytes.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Cations, Monovalent; Cysteine; Erythrocytes; Horses; Sodium; Substrate Specificity | 1985 |
Metabolism of sulfur-containing amino acids in the dermatophyte Microsporum gypseum. I. Neutral amino acids.
Topics: Alanine; Amino Acids, Sulfur; Arginine; Chromatography, Thin Layer; Cysteine; Cystine; Homocystine; Hydrogen-Ion Concentration; Methionine; Microsporum; Sulfates; Sulfides; Sulfites | 1985 |
Axonal transport of proteins in retinal ganglion cells. Amino acid incorporation into rapidly transported proteins and distribution of radioactivity to the lateral geniculate body and the superior colliculus.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axonal Transport; Cysteine; Female; Geniculate Bodies; Glycine; Histidine; Leucine; Lysine; Male; Methionine; Nerve Tissue Proteins; Optic Nerve; Phenylalanine; Proline; Rabbits; Retina; Superior Colliculi; Tritium; Tryptophan | 1972 |
The antibody binding site. Labelling of a specific antibody against the photo-precursor of an aryl nitrene.
Topics: Alanine; Amino Acids; Aminopeptidases; Animals; Antibodies; Arginine; Binding Sites; Blood Protein Electrophoresis; Cattle; Cysteine; Epitopes; gamma-Globulins; Glycine; Haptens; Iodoacetates; Lysine; Nitrophenols; Peptides; Photochemistry; Photolysis; Rabbits; Serum Albumin; Tritium; Trypsin | 1972 |
Altered glucoregulatory hormones during acute pneumococcal sepsis in the rhesus monkey.
Topics: Alanine; Amino Acids; Animals; Blood Cell Count; Blood Glucose; Cysteine; Fasting; Glucagon; Glucose; Glucose Tolerance Test; Growth Hormone; Haplorhini; Hydrocortisone; Injections, Intravenous; Insulin; Macaca; Male; Methods; Pneumococcal Infections; Streptococcus pneumoniae | 1974 |
Ferredoxin from a blue-green alga, Aphanothece sacrum (Suringar) Okada.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Cyanobacteria; Cysteine; Ferredoxins; Iron; Leucine; NADH, NADPH Oxidoreductases; Plants; Sulfur; Tyrosine | 1974 |
Equine antihapten antibody. VI. Subunits of polyalanylated gamma-G(T)-immunoglobulin.
Topics: Alanine; Alkylation; Animals; Antigen-Antibody Reactions; Antigens; Chemical Phenomena; Chemistry; Chromatography, Gel; Coloring Agents; Cysteine; Diphtheria Antitoxin; gamma-Globulins; Haptens; Horses; Immune Sera; Immunoelectrophoresis; Immunoglobulin G; Optical Rotatory Dispersion; Peptides; Rabbits; Ultracentrifugation | 1968 |
Measurement of intracellular amino acids in cultured skin fibroblasts. The effect of storage on cystine recovery and evaluation of three methods of cell preparation.
Topics: Alanine; Amino Acids; Cells, Cultured; Cysteine; Cystinosis; Edetic Acid; Female; Fibroblasts; Freezing; Glutamates; Glycine; Heterozygote; Humans; Isoleucine; Leucine; Male; Methods; Skin; Temperature; Trypsin; Valine | 1974 |
[Effect of different thiols on renal excretion of water and osmotically active substances in the rabbit].
Topics: Absorption; Alanine; Animals; beta-Aminoethyl Isothiourea; Cysteine; Dimercaprol; Kidney Concentrating Ability; Kidney Tubules; Osmolar Concentration; Penicillamine; Rabbits; Serine; Urine | 1968 |
[Effect of mercaptans on urine volume and osmolarity in rabbits].
Topics: Alanine; Animals; beta-Aminoethyl Isothiourea; Cysteine; Dimercaprol; Female; Kidney; Osmolar Concentration; Penicillamine; Rabbits; Receptors, Drug; Serine; Sodium Chloride; Thiosulfates; Urine; Vasopressins | 1969 |
Biosynthesis of the peptidoglycan of bacterial cell walls. 18. Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens.
Topics: Alanine; Carbon Isotopes; Cell Wall; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Cysteine; Electrophoresis; Electrophoresis, Disc; Glycine; Glycosaminoglycans; Hydrogen-Ion Concentration; Lactobacillus; Molecular Weight; Nickel; Oxidation-Reduction; RNA, Transfer; Serine; Transferases; Uracil Nucleotides | 1970 |
Proceedings: Inhibition of acetylcholine deactivating enzymes of the horse plasma by heavy metals and arsenic.
Topics: Acetates; Acetylcholine; Alanine; Animals; Arsenic; Cadmium; Copper; Cysteine; Dimercaprol; Dose-Response Relationship, Drug; Enzymes; Horses; In Vitro Techniques; Iron; Lead; Mercury; Metals; Nitrates; Physostigmine; Titanium; Zinc | 1974 |
Hepatic blood flow changes following intravenous infusion of various single amino acids in dogs. 3.
Topics: Alanine; Amino Acids; Animals; Arginine; Cysteine; Dogs; Electromagnetic Phenomena; Hepatic Artery; Hepatic Veins; Injections, Intravenous; Liver; Liver Circulation; Lysine; Phenylalanine; Portal System; Rheology; Stimulation, Chemical; Threonine; Tryptophan | 1974 |
Micromethod for the quantitative determination of L-alanine.
Topics: Alanine; Aminobutyrates; Cysteine; Isoleucine; Kinetics; Microchemistry; NAD; Serine; Spectrum Analysis; Valine | 1965 |
The divergence in reactivity of aminoacyl transfer ribonucleic acid synthetases of Escherichia coli with hydroxylamine.
Topics: Alanine; Amino Acids; Carbon Isotopes; Chromatography, Ion Exchange; Cysteine; Escherichia coli; Glutamates; Glycine; Hydroxylamines; Isoleucine; Kinetics; Leucine; Ligases; Lysine; Methionine; Periodic Acid; Phenylalanine; RNA, Bacterial; RNA, Transfer; Threonine; Tryptophan; Tyrosine | 1968 |
Cyanide metabolism in higher plants. 3. The biosynthesis of beta-cyanolanine.
Topics: Alanine; Amino Acids; Asparagine; Carbon Isotopes; Colorimetry; Cyanides; Cysteine; Hydro-Lyases; Hydrogen Cyanide; Plants; Serine; Stimulation, Chemical | 1968 |
Radical yield in X-irradiated biological molecules. II. Naturally-occurring amino-acids.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutamates; Histamine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Radiation Effects; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
On the neurotoxic effects induced by alkylating agents.
Topics: Alanine; Animals; Anti-Bacterial Agents; Antimetabolites; Azaserine; Behavior, Animal; Central Nervous System; Chlorambucil; Cyclophosphamide; Cysteine; Drug Antagonism; Glycine; Male; Mannitol; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Phenobarbital; Phenytoin; Rats; Seizures; Spasm; Thiourea; Triethylenemelamine; Tryptophan | 1966 |
Regulation of aspartate family amino acid biosynthesis in Brevibacterium flavum. I. Inhibition by amino acids of the enzymes in threonine biosynthesis.
Topics: Alanine; Alcohol Oxidoreductases; Amino Acids; Aspartate-Semialdehyde Dehydrogenase; Aspartic Acid; Brevibacterium; Cysteine; Glutathione; Isoleucine; Lyases; Lysine; Methionine; Phosphotransferases; Serine; Temperature; Threonine | 1968 |
Amino acids as olfactory stimuli in freshwater catfish, Ictalurus catus (Linn.).
Topics: Alanine; Amino Acids; Animals; Asparagine; Cysteine; Fishes; Glutamine; Methionine; Olfactory Mucosa; Stereoisomerism | 1971 |
Absorption of some amino acids by the haemoflagellate, Trypanosoma gambiense.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Transport; Carbon Isotopes; Cysteine; Glutamates; Glycine; Iodoacetates; Kinetics; Leucine; Lysine; Ornithine; Rats; Serine; Threonine; Trypanosoma brucei gambiense | 1972 |
Ornithine degradation in Clostridium sticklandii; pyridoxal phosphate and coenzyme A dependent thiolytic cleavage of 2-amino-4-ketopentanoate to alanine and acetyl coenzyme A.
Topics: Acetyl Coenzyme A; Alanine; Amino Acids; Apoproteins; Carbon Radioisotopes; Catalysis; Chromatography, Paper; Clostridium; Coenzyme A; Cysteine; Electrophoresis, Paper; Enzyme Activation; Keto Acids; Ornithine; Pyridoxal Phosphate; Species Specificity; Structure-Activity Relationship; Sulfhydryl Reagents; Thiolester Hydrolases; Valerates | 1974 |
Kinetic properties of pyruvate kinases from turtle liver and heart.
Topics: Alanine; Allosteric Regulation; Animals; Binding Sites; Citrates; Cysteine; Enzyme Activation; Fructosephosphates; Hexosediphosphates; Hydrogen-Ion Concentration; Isoleucine; Ketoglutaric Acids; Kinetics; Liver; Magnesium; Methionine; Myocardium; Organ Specificity; Phenylalanine; Phosphoenolpyruvate; Protein Binding; Pyruvate Kinase; Serine; Succinates; Tryptophan; Turtles; Valine | 1974 |
L-phenylalanine interactions with structurally related substances at the intestinal mucosa.
Topics: Alanine; Amino Acids; Animals; Binding Sites; Binding, Competitive; Biological Transport; Carbon Radioisotopes; Cysteine; Dihydroxyphenylalanine; Female; Intestinal Mucosa; Intestine, Small; Jejunum; Kinetics; Phenylalanine; Rats; Receptors, Drug; Serine; Time Factors | 1974 |
Navy (Haricot)-bean (Phaseolus vulgaris) lectin. Isolation and characterization of tow components from a toxic agglutinating extract.
Topics: Alanine; Animals; Aspartic Acid; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cysteine; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Glucosamine; Glycoproteins; Hemagglutination Tests; Horses; Lectins; Leucine; Leukocytes; Mannose; Methionine; Molecular Weight; Plant Lectins; Plants; Quail; Serine; Tryptophan | 1974 |
The role of amino acids as stimulants of antral release.
Topics: Acetylcholine; Alanine; Amino Acids; Animals; Choline; Cysteine; Dogs; Female; Gastric Fistula; Gastric Juice; Glycine; Histamine; Male; Pentagastrin; Phenylalanine; Pyloric Antrum; Secretory Rate; Serine; Stimulation, Chemical | 1974 |
Biosynthesis of 4-thiouridylate. Participation of a sulfurtransferase containing pyridoxal 5'-phosphate.
Topics: Alanine; Aldehydes; Borohydrides; Chromatography; Cysteine; Enzyme Activation; Escherichia coli; Hydroxyapatites; Hydroxylamines; Kinetics; Organophosphorus Compounds; Picolines; Pyridoxal Phosphate; Pyruvates; RNA, Transfer; Serine; Sulfhydryl Compounds; Sulfur Isotopes; Sulfurtransferases; Thiouridine; Uridine | 1972 |
Thiosine-resistant mutants of Escherichia coli K-12 with growth-medium-dependent lysl-tRNA synthetase activity. I. Isolation and physiological characterization.
Topics: Alanine; Amino Acids; Amino Acyl-tRNA Synthetases; Arginine; Carbon Isotopes; Culture Media; Cysteine; Drug Resistance, Microbial; Drug Stability; Escherichia coli; Ethylamines; Genotype; Glutamates; Kinetics; Lysine; Mutagens; Mutation; Species Specificity; Structure-Activity Relationship; Sulfonic Acids; Temperature; Time Factors | 1972 |
50-S ribosomal proteins. Purification and partial characterization of two acidic proteins, A 1 and A 2, isolated from 50-S ribosomes of Escherichia coli.
Topics: Alanine; Amino Acids; Autoanalysis; Bacterial Proteins; Chromatography, DEAE-Cellulose; Cysteine; Electrophoresis; Escherichia coli; Histidine; Isoelectric Focusing; Molecular Weight; Ribosomes; Sodium Dodecyl Sulfate; Tryptophan; Tyrosine; Ultracentrifugation | 1972 |
The stoichiometry and kinetics of the inducible cysteine desulfhydrase from Salmonella typhimurium.
Topics: Acrylates; Alanine; Amino Acids; Ammonium Sulfate; Bacterial Proteins; Binding, Competitive; Borohydrides; Carboxylic Acids; Cysteine; Enzyme Induction; Hydrogen-Ion Concentration; Kinetics; Lyases; Mathematics; Models, Chemical; Optical Rotatory Dispersion; Pyruvates; Salmonella typhimurium; Streptomycin; Sulfides; Thiazoles | 1973 |
The mechanism of action of fosfomycin (phosphonomycin).
Topics: Acyltransferases; Alanine; Amino Acids; Amino Sugars; Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Biological Transport; Cell Wall; Cysteine; Electrophoresis, Paper; Escherichia coli; Ethers, Cyclic; Kinetics; Micrococcus; Organophosphorus Compounds; Penicillins; Peptide Biosynthesis; Phosphoenolpyruvate; Phosphorus Radioisotopes; Salmonella typhimurium; Spheroplasts; Staphylococcus; Structure-Activity Relationship; Time Factors; Tritium; Uridine Diphosphate Sugars | 1974 |
Enhancement of iron absorption from ligated segments of rat intestine by histidine, cysteine, and lysine: effects of removing ionizing groups and of stereoisomerism.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Chelating Agents; Chemical Phenomena; Chemistry; Cysteine; Deamination; Decarboxylation; Duodenum; Histidine; Intestine, Small; Ions; Iron; Iron Isotopes; Ligation; Lysine; Male; Rats; Serine; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 1973 |
Release of cholecystokinin by amino acids.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Bicarbonates; Cholecystokinin; Cysteine; Dogs; Drug Synergism; Duodenum; Glutamates; Glycine; Intestinal Mucosa; Pancreas; Pancreatic Juice; Perfusion; Phenylalanine; Secretin; Threonine; Tryptophan | 1973 |
Synthesis of a biologically active insulin analog lacking the intrachain cyclic system.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Benzyl Compounds; Biological Assay; Cattle; Cysteine; Disulfides; Hydrazines; Insulin; Mice; Peptides; Proteins; Radioimmunoassay; Sheep; Structure-Activity Relationship; Sulfonic Acids | 1973 |
Quantitation of cyst(e)ine in human fibroblasts and separation of cysteines sulfinic acid, cysteic acid and taurine.
Topics: Alanine; Chromatography, Ion Exchange; Chromatography, Paper; Cysteine; Cystine; Cystinosis; Fibroblasts; Humans; Methods; Skin; Spectrophotometry; Sulfinic Acids; Sulfonic Acids; Sulfur Isotopes; Taurine | 1973 |
[Comparative studies on the influence of radioprotectors and amino acids on the chromosome-damaging activity of 8-hydroxyquinoline sulfate in human lymphocytes in vitro].
Topics: Alanine; Amino Acids; Arginine; Asparagine; beta-Aminoethyl Isothiourea; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; Cysteamine; Cysteine; Dose-Response Relationship, Drug; Glutamates; Histidine; Humans; Lymphocytes; Methionine; Quinolines | 1973 |
Nutrient media for plant parasitic nematodes. V. Amino acid nutrition of Aphelenchoides rutgersi.
Topics: Alanine; Amino Acids; Aminobutyrates; Culture Media; Cysteine; Cystine; Glutamine; Histidine; Isoleucine; Leucine; Methionine; Mitosporic Fungi; Nematoda; Phenylalanine; Reproduction; Tyrosine | 1973 |
Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues.
Topics: Adenosine Triphosphate; Adipose Tissue; Alanine; Allosteric Regulation; Animals; Brain; Cysteine; Enzyme Activation; Fructosephosphates; Isoenzymes; Kidney; Kinetics; Liver; Muscles; Phenylalanine; Phosphoenolpyruvate; Pyruvate Kinase; Rats | 1973 |
Intensities and other spectral parameters of infrared amide bands of polypeptides in the beta- and random forms.
Topics: Alanine; Amides; Amino Acid Sequence; Bombyx; Chemical Phenomena; Chemistry; Cysteine; Fibroins; Glycine; Lysine; Peptides; Polymers; Spectrophotometry, Infrared | 1973 |
[Chiro-optical properties of sulfur containing amino acids].
Topics: Alanine; Amino Acids; Circular Dichroism; Cystathionine; Cysteine; Cystine; Homocysteine; Homocystine; Hydrogen-Ion Concentration; Methionine; Molecular Conformation; Optical Rotatory Dispersion; Spectrophotometry, Ultraviolet; Sulfides; Sulfur; Temperature | 1973 |
The synthesis of taurine from sulfate. V. Regulatory modifiers of the chick liver enzyme system.
Topics: Adenosine Monophosphate; Alanine; Allosteric Regulation; Animals; Chickens; Cysteine; Ethionine; Homocysteine; Liver; Methionine; Organophosphorus Compounds; S-Adenosylmethionine; Serine; Sulfinic Acids; Sulfonic Acids; Sulfur Radioisotopes; Sulfuric Acids; Sulfurtransferases; Taurine | 1973 |
The instability of S-beta-(4-pyridylethyl)-L-cysteine to performic acid.
Topics: Alanine; Amino Acids; Autoanalysis; Chromatography, Gas; Cysteine; Drug Stability; Electrophoresis, Paper; Formates; Hydrogen-Ion Concentration; Hydrolysis; Indicators and Reagents; Oxidation-Reduction; Peroxides; Pyridines; Sulfinic Acids; Sulfones | 1973 |
Cyanylation of sulfhydryl groups by 2-nitro-5-thiocyanobenzoic acid. High-yield modification and cleavage of peptides at cysteine residues.
Topics: Alanine; Amino Acids; Benzoates; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Cysteine; Cystine; Disulfides; Electrophoresis, Paper; Glutathione; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Methods; Nitro Compounds; Oxidation-Reduction; Peptides; Spectrophotometry; Sulfhydryl Compounds; Thiocyanates | 1974 |
Effect of concentrations of ammonium molybdate, diammonium hydrogen phosphate, formaldehyde, and minerals in mixture on the synthesis of amino acids.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, Paper; Colorimetry; Cysteine; Formaldehyde; Glycine; Histidine; Minerals; Molybdenum; Organophosphorus Compounds; Quaternary Ammonium Compounds; Sterilization; Sunlight; Tyrosine | 1974 |
Specificity of amino acid transport in Trypanosoma equiperdum.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Binding Sites; Biological Transport; Carbon Radioisotopes; Culture Media; Cysteine; Diffusion; Glucose; Glutamates; Histidine; Lysine; Phenylalanine; Stimulation, Chemical; Trypanosoma | 1974 |
[On the radiation-protective effect of sulfhydryl group containing carbonic acids].
Topics: Alanine; Animals; Cysteamine; Cysteine; Escherichia coli; Female; Mice; Radiation Injuries, Experimental; Radiation-Protective Agents; Sulfhydryl Compounds | 1967 |
Effect of hypermethylation on the functional properties of transfer ribonucleic acid.
Topics: Alanine; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Cysteine; Escherichia coli; Glutamine; Glycine; Histidine; Isoleucine; Kinetics; Leucine; Methylation; RNA, Bacterial; RNA, Transfer | 1969 |
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
Topics: Alanine; Amino Acids; Ammonia; Catechols; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Culture Media; Cysteine; Electrophoresis; Escherichia coli; Feedback; Kinetics; Lyases; Methods; Molecular Weight; Phenols; Protamines; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Stereoisomerism; Sulfates; Tyrosine; Ultracentrifugation | 1970 |
[Formation of antibiotics antimetabolites of amino acids and vitamins by Actinomyces].
Topics: Actinomyces; Alanine; Amino Acids; Anti-Bacterial Agents; Antimetabolites; Arginine; Bacteria; Cysteine; Depression, Chemical; Escherichia coli; Flavobacterium; Glycine; Methionine; Ornithine; Pyridoxine; Streptomyces; Thiamine; Vitamins | 1971 |
The structure of bovine proinsulin.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Cattle; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Cysteine; Electrophoresis; Insulin; Islets of Langerhans; Pepsin A; Peptides; Polymers; Species Specificity; Sulfides; Swine; Trypsin | 1971 |
Prolonged survival of glutaraldehyde-treated skin homografts.
Topics: Alanine; Aldehydes; Animals; Binding Sites; Cysteine; Female; Glutarates; Graft Rejection; Lysine; Mice; Peptides; Phenylalanine; Polymers; Skin; Skin Transplantation; Time Factors; Transplantation Immunology; Transplantation, Homologous | 1971 |
Regulation of tryptophanase formation in Escherichia coli.
Topics: Alanine; Amino Acids; Culture Media; Cysteine; Enzyme Activation; Escherichia coli; Glycine; Homoserine; Lysine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenylalanine; Proteins; Serine; Time Factors | 1971 |
Serine metabolism in the culture form of Trypanosoma cruzi: synthesis of other amino acids.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Chromatography, Ion Exchange; Cysteine; Glutamates; Glycine; Protein Biosynthesis; Proteins; Serine; Threonine; Trypanosoma cruzi | 1971 |
Inhibition of the alanine tRNA aminoacylation by Ca 2+ .
Topics: Alanine; Amino Acids; Amino Acyl-tRNA Synthetases; Calcium; Carbon Isotopes; Cysteine; Escherichia coli; Kinetics; Proline; RNA, Transfer; Transfer RNA Aminoacylation | 1971 |
The B protein of Escherichia coli tryptophan synthetase. II. New -elimination and -replacement reactions.
Topics: Alanine; Carbon Isotopes; Chemical Phenomena; Chemistry; Chlorine; Cysteine; Escherichia coli; Ethers; Glycerophosphates; Hydro-Lyases; Indoles; Kinetics; Mercaptoethanol; Methanol; Models, Biological; Serine; Sulfhydryl Compounds; Sulfides; Tryptophan | 1971 |
Enzymatic formation of beta-cyanoalanine from cyanide.
Topics: Adenosine Triphosphate; Alanine; Chemical Phenomena; Chemistry; Chloromercuribenzoates; Cyanides; Cysteine; Edetic Acid; Hydroxylamines; Indicators and Reagents; Isoniazid; Magnesium; Mercury; Plants; Pyridoxal Phosphate; Semicarbazides; Serine | 1965 |
Studies on oral enzymes. VI. Hydrolysis of periodontal collagen by plaque enzyme extract.
Topics: Alanine; Collagen; Cysteine; Dental Plaque; Edetic Acid; Glycine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Indicators and Reagents; Periodontium; Phosphates; Phosphorus; Tissue Extracts | 1966 |
[Effects of various amino acids on the sensitivity of 11 strains of Staphylococcus aureus to penicillin G].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Glycine; Isoleucine; Leucine; Methionine; Penicillin G; Penicillin Resistance; Staphylococcus; Stereoisomerism; Tryptophan; Valine | 1969 |
[Effect of alanine and cysteine on the liver of mice of the R3 19c strain].
Topics: Alanine; Animals; Cysteine; Histocytochemistry; Liver; Mice | 1967 |
Inhibition of the amino acid induced initiation of germination of bacterial spores by chlorocresol.
Topics: Alanine; Bacillus subtilis; Cresols; Cysteine; Endopeptidases; Isoleucine; Leucine; Spores; Valine | 1970 |
Enzymic reduction of the C-terminal dehydroalanyl-lysine sequence in nisin.
Topics: Alanine; Anti-Bacterial Agents; Bacillus cereus; Binding Sites; Cysteine; Lysine; Oxidoreductases; Peptides | 1970 |
Partial purification, specificity and mechanism of action of the nisin-inactivating enzyme from Bacillus cereus.
Topics: Alanine; Anti-Bacterial Agents; Bacillus cereus; Buffers; Carbon Isotopes; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Gel; Cysteine; Drug Stability; Electrophoresis; Erythromycin; Hot Temperature; Hydrolysis; Kinetics; Lysine; Neomycin; Oxidoreductases; Penicillin G; Peptides; Stereoisomerism; Streptomycin; Tetracycline | 1971 |
Carboxy-terminal structure of the chain of human IgA myeloma proteins.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Antigens; Aspartic Acid; Bence Jones Protein; Blood Protein Electrophoresis; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Gel; Cyanides; Cysteine; Glutamates; Glycine; Humans; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Iodine Isotopes; Methods; Models, Structural; Oxidation-Reduction; Peptides; Rabbits; Sulfides; Thiocyanates; Threonine; Tyrosine; Valine | 1971 |
Formation of -cyanoalanine by O-acetylserine sulfhydrylase.
Topics: Acetates; Alanine; Ammonium Sulfate; Bacillus megaterium; Carbon Isotopes; Cell-Free System; Chemical Precipitation; Chromatography, DEAE-Cellulose; Colorimetry; Culture Media; Cyanides; Cysteine; Lyases; Protamines; Serine; Sulfates | 1971 |
-Bromo- -(5-imidazolyl)propionic acid and its reaction with cysteine.
Topics: Alanine; Amino Acids; Autoanalysis; Bromine; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Cysteine; Drug Stability; Histidine; Hydrogen-Ion Concentration; Imidazoles; Indicators and Reagents; Kinetics; Propionates; Stereoisomerism | 1972 |
Detection of non-protein amino acids in the presence of protein amino acids. II.
Topics: Alanine; Amino Acids; Autoanalysis; Buffers; Chemical Phenomena; Chemistry; Chromatography; Colorimetry; Cysteine; Hydrogen-Ion Concentration; Isoleucine; Methods; Proteins; Threonine; Urea; Valine | 1972 |
[Active center of rat liver homoserine dehydratase].
Topics: Alanine; Animals; Binding Sites; Cystathionine; Cysteine; Deamination; Homocysteine; Homoserine; Hydro-Lyases; Hydrogen Sulfide; Kinetics; Liver; Methionine; Protein Binding; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 1972 |
Rat liver cysteine sulfinate decarboxylase: some observations about substrate specificity.
Topics: Alanine; Ammonium Sulfate; Animals; Carboxy-Lyases; Chemical Precipitation; Chromatography, Gel; Cysteine; Cytoplasm; Kinetics; Liver; Male; Molecular Weight; Nitrogen; Oxygen; Rats; Structure-Activity Relationship; Sulfonic Acids | 1972 |
Influence of nutrition on the morphology of a strain of Bifidobacterium bifidum.
Topics: Acetates; Alanine; Amino Acids; Asparagine; Aspartic Acid; Culture Media; Cysteine; Glutamates; Lactobacillus; Mutation; Nutritional Physiological Phenomena; Quaternary Ammonium Compounds; Serine; Surface-Active Agents; Tryptophan | 1972 |
Selective free radical reactions with proteins and enzymes: reactions of inorganic radical anions with amino acids.
Topics: Alanine; Amino Acids; Bromides; Carbonates; Chlorides; Cysteine; Free Radicals; Histidine; Hydrogen-Ion Concentration; Iodides; Kinetics; Methionine; Muramidase; Proteins; Radiation Effects; Radiochemistry; Spectrophotometry; Thiocyanates; Tryptophan; Tyrosine | 1972 |
Oxidative deamination of sulfonyl, sulfonyl and thiosulfonyl amino acids by D-aspartate oxidase.
Topics: Alanine; Amino Acid Oxidoreductases; Amino Acids; Animals; Aspartic Acid; Cattle; Cysteine; Deamination; Homocysteine; Kidney; Kinetics; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Rabbits; Sulfinic Acids; Sulfonic Acids; Swine | 1972 |
Cystathionine -synthase. Studies of hydrogen exchange reactions.
Topics: Alanine; Aminobutyrates; Catalysis; Chemical Phenomena; Chemistry; Cystathionine; Cysteine; Deuterium; Homoserine; Kinetics; Lyases; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Salmonella; Serine; Succinates; Tritium | 1972 |
Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine -synthase.
Topics: Acetates; Alanine; Amino Acids; Animals; Catalysis; Chickens; Chlorine; Chromatography, Gel; Chromatography, Paper; Cycloserine; Cysteamine; Cysteine; Electrophoresis, Paper; Glycolates; Homocysteine; Hydro-Lyases; Hydroxylamines; Isoelectric Focusing; Kinetics; L-Serine Dehydratase; Liver; Mercaptoethanol; Nitriles; Penicillamine; Propionates; Pyridoxal Phosphate; Rats; Serine; Species Specificity; Sulfhydryl Compounds; Sulfides; Sulfuric Acids; Thioglycolates | 1971 |
Amino acid sequence of the Peptostreptococcus elsdenii flavodoxin.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Bacterial Proteins; Binding Sites; Cyanogen Bromide; Cysteine; Flavin Mononucleotide; Methionine; Peptides; Peptostreptococcus; Protein Binding; Trypsin | 1971 |
Effect of substrate structure on coupling ratio for Na + -dependent transport of amino acids.
Topics: Alanine; Amino Acids; Animals; Asparagine; Biological Transport; Carbon Isotopes; Columbidae; Cysteine; Erythrocytes; Hydroxyproline; Kinetics; Models, Biological; Models, Structural; Potassium; Potassium Isotopes; Proline; Serine; Sodium; Sodium Chloride; Sodium Isotopes; Structure-Activity Relationship; Threonine; Tritium | 1971 |
The effect of vitamin C depletion on the free amino acid content in blood plasma of the guinea pig.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Ascorbic Acid Deficiency; Aspartic Acid; Citrulline; Cysteine; Glutamates; Glycine; Guinea Pigs; Histidine; Isoleucine; Lysine; Male; Methionine; Ornithine; Phenylalanine; Proline; Serine; Threonine; Time Factors; Tyrosine; Valine | 1971 |
The hydrolysis by thermolysin of dipeptide derivatives that conatin substituted cysteine.
Topics: Alanine; Amides; Crystallization; Cysteine; Dipeptides; Endopeptidases; Hydrolysis; Kinetics; Leucine; Phenylalanine; Thermolysin; Valine | 1971 |
Amino- and carboxyl-terminal amino acid sequences of the Peptostreptococcus eisdenii and Clostridium pasteurianum flavodoxins.
Topics: Alanine; Alkylation; Amino Acid Sequence; Amino Acids; Bacterial Proteins; Carboxypeptidases; Chromatography, Gas; Chromatography, Thin Layer; Clostridium; Cysteine; Desulfovibrio; Flavin Mononucleotide; Flavoproteins; Hydrazines; Kinetics; Leucine; Lysine; Molecular Weight; Peptostreptococcus; Protein Binding; Species Specificity; Structure-Activity Relationship; Valine | 1971 |
[Dissociation of S- and P-variants of Bacillus brevis var. G.-B. on a synthetic medium with amino acids as the only source of nitrogen].
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Culture Media; Cysteine; Genetic Variation; Glycine; Histidine; Leucine; Lysine; Mutation; Nitrogen; Ornithine; Phenylalanine; Serine; Stimulation, Chemical; Threonine; Time Factors; Tryptophan; Valine | 1971 |
Dissociation constants of lanthionine and its structure in aqueous solution.
Topics: Alanine; Amino Acids; Chemical Phenomena; Chemistry; Chlorine; Computers; Cysteine; Deuterium; Dicarboxylic Acids; Hydrogen-Ion Concentration; Infrared Rays; Magnetic Resonance Spectroscopy; Mathematics; Models, Chemical; Nitrates; Optical Rotatory Dispersion; Potentiometry; Sodium; Spectrophotometry; Stereoisomerism; Sulfides; Temperature; Thermodynamics; Tosyl Compounds | 1971 |
Hyperaminoacidemia in rabbits treated with 6-azauridine triacetate.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Antimetabolites; Cystathionine; Cysteine; Homocysteine; Male; Methionine; Nucleosides; Rabbits | 1971 |
The photochemical degradation of cystine in aqueous solutions in the presence of nitrogen.
Topics: Air; Alanine; Amino Acids; Ammonia; Chemical Phenomena; Chemistry; Cysteine; Cystine; Dicarboxylic Acids; Electrophoresis; Hydrogen Sulfide; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Nitrogen; Photolysis; Radiation Effects; Sulfides; Sulfinic Acids; Sulfur; Ultraviolet Rays | 1971 |
Allosteric properties of skeletal muscle pyruvate kinase.
Topics: Alanine; Allosteric Regulation; Animals; Cysteine; Drug Interactions; Enzyme Activation; Glyceric Acids; Hydrogen-Ion Concentration; Kinetics; Muscles; Phenylalanine; Pyruvate Kinase; Rabbits; Serine | 1971 |
Oxidative deamination of sulfur amino acids by bacterial and snake venom L-amino acid oxidase.
Topics: Adenosine; Alanine; Amino Acid Oxidoreductases; Animals; Catalase; Cattle; Chromatography, Thin Layer; Cysteine; Cystine; Homocysteine; Homocystine; Hydrogen-Ion Concentration; Kinetics; Liver; Methionine; Models, Biological; Models, Structural; Oxygen Consumption; Proteus; S-Adenosylmethionine; Snakes; Species Specificity; Sulfides; Sulfur; Venoms | 1971 |
Antibodies reactive with native lysozyme elicited by a completely synthetic antigen.
Topics: Alanine; Amino Acids; Animals; Antibodies; Antigen-Antibody Reactions; Bacteriophages; Carbon Isotopes; Chemical Phenomena; Chemistry; Cross Reactions; Cysteine; Electrophoresis; Energy Transfer; Fluorometry; Goats; Iodine Isotopes; Molecular Weight; Muramidase; Naphthalenes; Oxidation-Reduction; Paper; Peptides; Polysaccharides; Rabbits; Sulfonic Acids; Trypsin; Ultracentrifugation | 1971 |
[Amino acid determination in the aqueous humor and vitreous body of single eyes].
Topics: Alanine; Amino Acids; Animals; Aqueous Humor; Aspartic Acid; Chromatography, Ion Exchange; Cysteine; Glutamates; Glycine; Leucine; Phenylalanine; Rabbits; Taurine; Vitreous Body | 1969 |
Amino acid replacements associated with reversion and recombination within a coding unit.
Topics: Alanine; Amino Acids; Aspartic Acid; Cysteine; Escherichia coli; Genetic Code; Genetics; Glycine; In Vitro Techniques; Isoleucine; Ligases; Lysine; Mutation; Peptides; Serine; Tryptophan; Valine | 1965 |
RNA codewords and protein synthesis, 8. Nucleotide sequences of synonym codons for arginine, valine, cysteine, and alanine.
Topics: Alanine; Arginine; Bacterial Proteins; Chemical Phenomena; Chemistry; Cysteine; Escherichia coli; Genetic Code; In Vitro Techniques; Nucleotides; Ribosomes; RNA, Transfer; Valine | 1965 |
Enzymatic formation of beta-cyanoalanine from cyanide by Escherichia coli extracts.
Topics: Adenosine Triphosphate; Alanine; Carbon Isotopes; Chemical Phenomena; Chemistry; Cyanides; Cysteine; Escherichia coli; Magnesium; Serine; Sulfides; Threonine | 1965 |
Studies on polynucleotides. LXXIV. Direct translation in vitro of single-stranded DNA-like polymers with repeating nucleotide sequences in the presence of neomycin B.
Topics: Alanine; Carbon Isotopes; Chromatography, Paper; Cysteine; DNA, Bacterial; Escherichia coli; Genetic Code; Histidine; Methionine; Neomycin; Peptide Biosynthesis; Polynucleotides; Ribosomes; RNA, Transfer; Thiocyanates; Threonine; Valine | 1967 |
Studi on siomycin. II. The composition and degradation products of siomycin A.
Topics: Acetaldehyde; Alanine; Amino Acids; Anti-Bacterial Agents; Butyrates; Carbon; Chemical Phenomena; Chemistry; Cysteine; Optical Rotatory Dispersion; Oxidation-Reduction; Propionates; Pyruvates; Quinazolines; Thiazoles; Threonine; Valine | 1969 |
Studies on amino acid racemases. I. Partial purification and properties of the alanine racemase from Lactobacillus fermenti.
Topics: Acetates; Alanine; Aminobutyrates; Aspartic Acid; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Computers; Cysteine; Drug Stability; Glutamates; Glutathione; Hydrogen-Ion Concentration; Isomerases; Kinetics; Lactobacillus; Mercaptoethanol; Methods; Models, Biological; Models, Chemical; Pyridoxal Phosphate; Serine; Stereoisomerism; Temperature | 1969 |
Transaminase activity in sheep rumen content.
Topics: Alanine; Alanine Transaminase; Animals; Arginine; Aspartic Acid; Cysteine; Eukaryota; Glutamates; Hydrogen-Ion Concentration; Isoleucine; Leucine; Methionine; Phenylalanine; Rumen; Serine; Sheep; Temperature; Threonine; Tryptophan; Tyrosine; Valine | 1969 |
Reaction of dithionite and bisulfite with pyridoxal and pyridoxal enzymes.
Topics: Alanine; Alanine Transaminase; Aspartate Aminotransferases; Chemical Phenomena; Chemistry; Cysteine; Enzymes; Isomerases; Pyridoxal Phosphate; Spectrophotometry; Sulfites | 1969 |
Reduction of S-carboxymethylcysteine and methionine with sodium in liquid ammonia.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Cold Temperature; Cysteine; Glutathione; Glycine; Insulin; Keratins; Methionine; Oxidation-Reduction; Peptides; Sodium; Time Factors; Wool | 1969 |
Effects of omega-amino acids and related compounds on staphylococcal infections in mice: a combined prophylactic-therapeutic procedure.
Topics: Alanine; Amino Acids; Aminobutyrates; Aminocaproates; Animals; Culture Media; Cyclohexanecarboxylic Acids; Cysteine; Dipeptides; Female; Glycine; Histidine; Hydroxybutyrates; Injections, Subcutaneous; Mice; Staphylococcal Infections; Staphylococcus; Sulfinic Acids; Taurine; Valerates | 1970 |
[Biosynthesis of gramicidin C on synthetic media with amino acids as the only N source].
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Culture Media; Cysteine; Glycine; Histidine; Hydrogen-Ion Concentration; Leucine; Lysine; Nitrogen; Ornithine; Phenylalanine; Serine; Threonine; Tryptophan; Tyrothricin; Valine | 1970 |
Glutamate and related amino acids in cat spinal roots, dorsal root ganglia and peripheral nerves.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cats; Cysteamine; Cysteine; Ganglia, Spinal; Glutamates; Glycine; Peripheral Nerves; Spinal Nerves | 1970 |
Amino acid sequence analysis with methyl isothiocyanate. Resolution of the methylthiohydantoins by gas-liquid partition chromatography.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Bence Jones Protein; Cattle; Chromatography, Gas; Cysteine; Dipeptides; Glutamates; Hydantoins; Indicators and Reagents; Insulin; Methods; Serine; Serum Albumin, Bovine; Solvents; Thiocyanates; Threonine | 1970 |
[Metabolism of drugs. LXVI. Studies on the metabolic fate of pantethine].
Topics: Alanine; Animals; Carbon Isotopes; Chromatography; Cysteine; Male; Pantothenic Acid; Rabbits; Rats; Spectrum Analysis; Sulfides | 1970 |
Determination of pico-mole quantities of gamma-amino-butyric acid (GABA) and serotonin.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoradiography; Brain Chemistry; Carbon Isotopes; Cerebellum; Chromatography; Cysteine; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methods; Microchemistry; Phenylalanine; Proline; Radionuclide Imaging; Rats; Serine; Serotonin; Threonine; Tyrosine; Valine | 1970 |
A comparative study on the affinity labelling of aspartate aminotransferase isozymes by beta-bromopyruvate.
Topics: Alanine; Aldehydes; Animals; Aspartate Aminotransferases; Bromine; Chemical Phenomena; Chemistry; Cysteine; Isoenzymes; Mitochondria, Muscle; Myocardium; Picolines; Protein Denaturation; Pyruvates; Sulfinic Acids; Swine | 1970 |
[Effect of amino acids on the growth of Streptococcus lactis and biosynthesis of nisin].
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Depression, Chemical; Glutamates; Glycine; Histidine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Stimulation, Chemical; Streptococcus; Threonine; Tryptophan; Valine | 1970 |
Lysine uptake in cultured Trypanosoma cruzi: interactions of competitive inhibitors.
Topics: Alanine; Animals; Biological Transport; Cysteine; Glycine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Trypanosoma; Tyrosine; Valine | 1970 |
Transport of penicillamine across mucosa of the rat small intestine in vitro.
Topics: Alanine; Animals; Benzoates; Biological Transport; Chemical Phenomena; Chemistry; Chromatography; Cyanides; Cysteine; In Vitro Techniques; Indicators and Reagents; Intestinal Mucosa; Intestine, Small; Inulin; Male; Mathematics; Penicillamine; Potassium; Pyridoxine; Rats; Spectrophotometry; Stereoisomerism; Sulfhydryl Reagents; Sulfides; Sulfur Isotopes; Tetroses; Valine; Water | 1970 |
Effect of Tween 80 on alkaloid-producing cultures of Claviceps paspali.
Topics: Acids; Alanine; Amino Acids; Ascomycota; Chromatography, Paper; Citrates; Colorimetry; Culture Media; Cysteine; Ergot Alkaloids; Fumarates; Histidine; Methionine; Oxaloacetates; Spectrophotometry; Succinates; Surface-Active Agents | 1971 |
Biosynthesis of -cyanoalanine in Vicia sativa.
Topics: Alanine; Carbon Isotopes; Cyanides; Cysteine; Glutamates; Nitriles; Plants; Potassium; Protein Binding; Serine; Time Factors; Toxins, Biological | 1971 |
[Dissociation of R- and P plus-variants of Bacillus brevis var. G.-B. during growth on a synthetic medium with amino acids as the only source of nitrogen].
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Culture Media; Cysteine; Genetic Variation; Glycine; Histidine; Leucine; Lysine; Nitrogen; Ornithine; Phenylalanine; Serine; Threonine; Tryptophan; Valine | 1971 |
Serine transhydroxymethylase. Affinity of the active site for substrates, substrate analogues, and anions.
Topics: Alanine; Aldehydes; Aminoisobutyric Acids; Animals; Benzoates; Binding Sites; Chlorides; Cysteamine; Cysteine; Electrophoresis; Folic Acid; Glycine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Models, Biological; Organophosphonates; Phosphates; Potassium; Propionates; Pyridoxal Phosphate; Rabbits; Serine; Spectrophotometry; Stereoisomerism; Sulfates; Sulfhydryl Compounds; Sulfonic Acids; Thermodynamics; Threonine; Transferases; Ultracentrifugation | 1971 |
Cyanogen bromide fragments of human serum albumin.
Topics: Acetamides; Alanine; Amino Acids; Aspartic Acid; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cyanides; Cysteine; Electrophoresis; Formates; Guanidines; Humans; Hydrogen-Ion Concentration; Iodoacetates; Leucine; Methods; Naphthalenes; Oxidation-Reduction; Peptides; Phenylalanine; Proline; Quaternary Ammonium Compounds; Serum Albumin; Sulfates; Sulfhydryl Reagents; Sulfonic Acids; Tetroses; Urea | 1971 |
Transsulfuration in higher plants. Partial purification and properties of beta-cystathionase of spinach.
Topics: Alanine; Amino Acids; Benzoates; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Cysteine; Drug Stability; Edible Grain; Ethylmaleimide; Homocysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; Models, Structural; Plants; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Species Specificity; Spectrophotometry; Stereoisomerism; Sulfates; Sulfides; Sulfur; Triticum | 1971 |
Studies on adrenal steroid hydroxylases. The reactivity of triphenyl phosphine with labile sulfur in adrenal iron-sulfur protein (adrenodoxin).
Topics: Adrenal Glands; Air; Alanine; Animals; Benzene Derivatives; Bromine; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; Cysteine; Ferredoxins; Hydrocarbons, Halogenated; Iron; Kinetics; Models, Structural; Nickel; Nitrogen; Organometallic Compounds; Phosphines; Pyruvates; Serine; Spectrophotometry; Sulfhydryl Compounds; Sulfides; Trichloroacetic Acid; Tritium | 1971 |
Desulfurization of sulfur amino acids and proteins with Raney nickel.
Topics: Acetates; Alanine; Albumins; Boron Compounds; Catalysis; Chemical Phenomena; Chemistry; Cysteine; Cystine; Globins; Hydrogen-Ion Concentration; Methionine; Muramidase; Nickel; Proteins; Sulfur; Temperature | 1971 |
[Free amino acids and other ninhydrin-positive substances in the normal horny layer and in psoriasis scales].
Topics: Alanine; Amino Acids; Ammonia; Asparagine; Chromatography; Citrulline; Cysteine; Glycine; Histidine; Humans; Imidazoles; Phenylalanine; Proline; Psoriasis; Serine; Skin; Taurine; Threonine; Urea | 1967 |
[Biosphere products of Sinapis alba. I. Rhizosphere products].
Topics: Alanine; Amino Acids; Aminobutyrates; Arabinose; Arginine; Aspartic Acid; Citrates; Cysteine; Glucose; Glutamates; Glycine; Hexoses; Histidine; Keto Acids; Leucine; Mannose; Mustard Plant; Oxalates; Pentoses; Plants, Medicinal; Proline; Ribose; Threonine; Valine; Xylose | 1967 |
[On the interactions between an active dye and thioenzymes].
Topics: Alanine; Animals; Coloring Agents; Cysteine; Fructose-Bisphosphate Aldolase; Glutathione; Hydrogen-Ion Concentration; Lysine; Muscle Proteins; Papain; Temperature | 1967 |
[Quantitative paper chromatography amino acid determination. Stanardization of the procedure and method of testing of new paper types].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chromatography, Paper; Cysteine; Glutamates; Glycine; Histidine; Indicators and Reagents; Leucine; Lysine; Methionine; Methods; Paper; Phenylalanine; Serine; Spectrum Analysis; Sulfones; Threonine; Tyrosine; Ultraviolet Rays; Valine | 1967 |
[Isolation, fractionation, sedimentation studies and investigation of characteristic amino acids of ox brain histones].
Topics: Alanine; Amino Acids; Animals; Arginine; Brain Chemistry; Cattle; Cell Nucleus; Chemical Phenomena; Chemistry; Cysteine; Glutamates; Histones; Lysine; Thymus Gland; Ultracentrifugation | 1967 |
Ammonia production by rumen microbes in vitro.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Asparagine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rumen; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
The cobalt-60 gamma radiolysis of cysteine in deaerated aqueous solutions at pH values between 5 and 6.
Topics: Alanine; Chemical Phenomena; Chemistry, Physical; Cobalt Isotopes; Cysteine; Cystine; Hydrogen-Ion Concentration; Radiation Effects; Water | 1968 |
Biosynthesis of the peptidoglycan of bacterial cell walls. 8. Specificity in the utilization of L-alanyl transfer ribonucleic acid for interpeptide bridge synthesis in Arthrobacter crystallopoietes.
Topics: Alanine; Arthrobacter; Carbon Isotopes; Cell Wall; Cysteine; Peptide Biosynthesis; Polysaccharides, Bacterial; RNA, Bacterial; RNA, Transfer; Uracil Nucleotides | 1968 |
The optical activity of the disulfide bond in L-cystine and some derivatives of L-cystine.
Topics: Alanine; Amides; Chemical Phenomena; Chemistry; Cysteine; Cystine; Spectrum Analysis; Sulfides | 1968 |
Amino acid synthesis from glucose-U-14C in Argyrotaenia velutinana (Lepidoptera: Tortricidae) larvae.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Carbon Isotopes; Colorimetry; Cysteine; Glucose; Glutamates; Glycine; Insecta | 1968 |
Primary structure of insoluble tendon collagen. 3. Analysis of products of tryptic digestion of native collagen.
Topics: Achilles Tendon; Alanine; Aldehydes; Amino Acids; Animals; Arginine; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Collagen; Cysteine; Electrophoresis; Glutamine; Glycine; Hexosamines; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Proline; Serine; Sulfur; Threonine; Trypsin; Tyrosine; Valine | 1968 |
Trace metal requirements for malformin biosynthesis.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Aspartic Acid; Aspergillus; Chromium; Cobalt; Copper; Cysteine; Glutamine; Glycine; Histidine; Iron; Isoleucine; Leucine; Lysine; Manganese; Metals; Molybdenum; Peptide Biosynthesis; Phenylalanine; Plant Growth Regulators; Proline; Serine; Trace Elements; Tryptophan; Tyrosine; Valine; Zinc | 1968 |
One step synthesis of alpha-sulfo-beta-alanine.
Topics: Alanine; Chemical Phenomena; Chemistry; Cysteine; Oxidation-Reduction; Sulfur | 1968 |
[On the influence of the starting position on migration of substances in paper electrophoresis].
Topics: Alanine; Amino Acids; Aminobutyrates; Arginine; Asparagine; Cysteine; Electrophoresis; Glucose; Glutamates; Glutamine; Glycine; Histidine; Leucine; Lysine; Methionine; Serine; Serum Albumin; Taurine; Tryptophan | 1968 |
Mixed chelates of Ca(II)-pyridine-2,6-dicarboxylate with some amino acids related to bacterial spores.
Topics: Alanine; Amino Acids; Bacteria; Bacterial Proteins; Calcium; Chelating Agents; Cysteine; Glycine; Hydrogen-Ion Concentration; Picolinic Acids; Potentiometry; Spores | 1968 |
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.
Topics: Alanine; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Gel; Colorimetry; Cyanides; Cysteine; Electrophoresis; Lyases; Plants, Edible; Serine; Sulfides; Toxins, Biological | 1969 |
The effects of various vitamin B6 5'-phosphate derivatives on the structure and activities of L-aspartate beta-decarboxylase.
Topics: Alanine; Alcaligenes; Amines; Aspartic Acid; Binding Sites; Carbon Isotopes; Carboxy-Lyases; Chemical Phenomena; Chemistry; Cysteine; Dialysis; Electrophoresis; Fluorometry; Hydrolases; Kinetics; Models, Chemical; Molecular Weight; Pyridoxal Phosphate; Pyridoxine; Pyruvates; Spectrum Analysis; Sulfur; Transaminases | 1969 |
Structure of Mn2+ and Cu2+ complexes with L-methionine, S-methyl-L-cysteine, L-threonine and L-serine.
Topics: Alanine; Amino Acids; Aminobutyrates; Binding Sites; Chemical Phenomena; Chemistry; Copper; Cysteine; Drug Stability; Keto Acids; Magnetic Resonance Spectroscopy; Manganese; Methionine; Serine; Sulfur; Threonine | 1969 |
The specificity of purified porcine pancreatic elastase.
Topics: Alanine; Animals; Chromatography; Cysteine; Electrophoresis; Glutamates; Glycine; Histidine; Insulin; Leucine; Pancreas; Pancreatic Elastase; Phenylalanine; Serine; Swine; Valine | 1969 |
Stereochemical specificity of neutral amino acid transfer systems in rat small intestine.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Cysteine; Hydroxyproline; Ileum; Intestine, Small; Jejunum; Leucine; Methionine; Pipecolic Acids; Proline; Rats; Sarcosine; Serine; Stereoisomerism | 1969 |
Glutamyl-L-cysteinyl-beta-alanine.
Topics: Alanine; Chemical Phenomena; Chemistry; Cysteine; Glutamates; Peptides | 1963 |
[Effect of the C-source on the growth requirements of acetic acid bacteria].
Topics: Acetobacter; Alanine; Amino Acids; Bacteria; Carbon; Cysteine; Cystine; Ethanol; Glucose; In Vitro Techniques; Vitamins | 1965 |
The conversion of L-beta-chloroalanine peptides to L-cysteine peptides.
Topics: Alanine; Chemical Phenomena; Chemistry; Cysteine; Peptides | 1966 |
On the synthesis of taurine from sulfate by the chick. I. Influential dietary factors.
Topics: Alanine; Amino Alcohols; Animals; Cysteine; Diet; Glycine; In Vitro Techniques; Kidney; Liver; Myocardium; Poultry; Pyruvates; Serine; Spleen; Sulfates; Sulfites; Taurine; Thiosulfates | 1966 |
Water relations of Salmonella oranienburg; stimulation of respiration by amino acids.
Topics: Alanine; Asparagine; Aspartic Acid; Carbon Isotopes; Culture Media; Cysteine; Glucose; Glutamine; Glycine; Methionine; Oxygen Consumption; Proline; Salmonella; Serine; Threonine; Water | 1966 |
Reducing compounds and the growth of Phytophthora infestans.
Topics: Alanine; Amino Acids; Ascorbic Acid; Cysteine; Cystine; Fungi; Glutathione; Glycolates; Light; Methionine; Thioglycolates | 1966 |
Analysis of N-methylamino acids by automatic amino acid analyzer and gas-liquid chromatography.
Topics: Alanine; Anti-Bacterial Agents; Arginine; Aspartic Acid; Autoanalysis; Chromatography, Gas; Cysteine; Cystine; Glutamates; Glycine; Indicators and Reagents; Isoleucine; Lysine; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1966 |
[Composition and properties of the preparations isolated from Act. coelicolor with the aid of beta-naphtol].
Topics: Acetates; Actinomyces; Alanine; Arginine; Aspartic Acid; Chromatography, Paper; Cysteine; Glucosamine; Glutamates; Glycerol; Leucine; Lysine; Naphthalenes; Peptides; Phosphates; Ribose; Serine; Valine | 1966 |
Amino acid esters as inhibitors of growth and of aminoacyl transfer ribonucleic acid synthetases in Euglena and Astasia.
Topics: Alanine; Amino Acids; Antimetabolites; Aspartic Acid; Cysteine; Esters; Euglena; Eukaryota; Glutamates; Hydrogen-Ion Concentration; Leucine; Ligases; Methionine; Phenylalanine; RNA, Transfer; Tryptophan; Tyrosine | 1967 |
Electron microscopic and biochemical characterization of collagen in blattarian insects.
Topics: Alanine; Ammonia; Animals; Arginine; Aspartic Acid; Collagen; Connective Tissue Cells; Cysteine; Cystine; Female; Glutamates; Glycine; Histidine; Histocytochemistry; Hydroxyproline; Insecta; Isoleucine; Leucine; Lysine; Male; Methionine; Microscopy, Electron; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1967 |
Rapid short-column chromatography of amino acids. A method for blood and urine specimens in the diagnosis and treatment of metabolic disease.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Aminobutyrates; Autoanalysis; Buffers; Chromatography, Ion Exchange; Citrates; Cysteine; Cystine; Glutamates; Glutamine; Glycine; Humans; Hydrogen-Ion Concentration; Hydroxyproline; Isoleucine; Phenylalanine; Proline; Sarcosine; Serine; Threonine; Tyrosine; Valine | 1967 |
Requirements for growth of Streptococcus agalactiae in a chemically defined medium.
Topics: Alanine; Ascorbic Acid; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Proline; Serine; Streptococcus; Thioglycolates | 1967 |
The influence of nitrogenous compounds on growth of Pythium species.
Topics: Alanine; Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Cysteine; Fungi; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Nitrates; Nitrites; Nitrogen; Peptones; Quaternary Ammonium Compounds; Serine; Succinates; Threonine; Yeast, Dried | 1967 |
A distinct Na+-requiring transport system for alanine, serine, cysteine, and similar amino acids.
Topics: Alanine; Amino Acids; Animals; Carcinoma, Ehrlich Tumor; Cysteine; Depression, Chemical; Kinetics; Radiation Effects; Serine; Sodium | 1967 |
The metabolism of L-asparagine in Asparagus officinalis.
Topics: Alanine; Asparagine; Aspartate Aminotransferases; Aspartate-Ammonia Ligase; Biochemistry; Chromatography, Gel; Cyanides; Cysteine; France; History, 19th Century; Hydro-Lyases; Lyases; Plants; Substrate Specificity | 1980 |
Probing the principles of amino acid selection using the alanyl-tRNA synthetase from Escherichia coli.
Topics: Alanine; Alanine-tRNA Ligase; Amino Acyl-tRNA Synthetases; Aminobutyrates; Cysteine; Escherichia coli; Kinetics; Pyrophosphatases; RNA, Transfer; Substrate Specificity | 1981 |
Roles of cysteine sulfinate and transaminase on in vitro dark reversion of urocanase in Pseudomonas putida.
Topics: Alanine; Cysteine; Darkness; Glutamates; Glutamic Acid; Hydro-Lyases; Neurotransmitter Agents; Pseudomonas; Taurine; Transaminases; Ultraviolet Rays; Urocanate Hydratase | 1982 |
Characteristics of cysteine uptake in intestinal basolateral membrane vesicles.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Cysteine; Intestine, Small; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1984 |
Taurine biosynthesis in frog retina: effects of light and dark adaptations.
Topics: Adaptation, Physiological; Alanine; Animals; Cysteic Acid; Cysteine; Dark Adaptation; Light; Neurotransmitter Agents; Rana catesbeiana; Retina; Taurine | 1983 |
Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity.
Topics: Alanine; Animals; Aspartic Acid; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Cysteine; Drug Synergism; Glutathione; Ketones; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Maleates; Rats; Rats, Inbred Strains; Transaminases; Triglycerides | 1984 |
Studies on the utilization of lysinoalanine and lanthionine.
Topics: Alanine; Amino Acids; Animals; Chickens; Cysteine; Dietary Proteins; Female; Hydrogen-Ion Concentration; Kidney; Lysine; Lysinoalanine; Male; Nutritive Value; Rats; Species Specificity; Structure-Activity Relationship; Sulfides | 1980 |
Localization of a cross-link donor site in the alpha-chain of human fibrin.
Topics: Alanine; Amino Acid Sequence; Cross-Linking Reagents; Cyanogen Bromide; Cysteine; Fibrin; Fibrinogen; Lysine; Peptides; Threonine; Valine | 1980 |
Amino acid transport via the red cell anion transport system.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Alanine; Amino Acids; Biological Transport; Carrier Proteins; Cysteine; Depression, Chemical; Erythrocytes; Glycine; Humans; In Vitro Techniques; Proline; Serine; Threonine; Valine | 1981 |
Synthesis of D-cysteine from 3-chloro-D-alanine and hydrogen sulfide by 3-chloro-D-alanine hydrogen chloride-lyase (deaminating) of Pseudomonas putida.
Topics: Alanine; beta-Alanine; Cysteine; Hydrogen Sulfide; Hydrogen-Ion Concentration; Kinetics; Lyases; Pseudomonas; Spectrophotometry, Infrared; Stereoisomerism | 1981 |
The transport of alanine, serine, and cysteine in cultured human fibroblasts.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Aminoisobutyric Acids; Biological Transport; Cells, Cultured; Cysteine; Fibroblasts; Humans; Kinetics; Serine; Sodium | 1982 |
Transport of L-cysteine by rat renal brush border membrane vesicles.
Topics: Alanine; Animals; Biological Transport; Cell-Free System; Cysteine; Cystine; Kidney; Male; Membrane Potentials; Microvilli; Phenylalanine; Rats; Sodium; Stereoisomerism; Sulfhydryl Compounds | 1983 |
Transformation of dehydroalanine residues in casein to S-beta-(2-pyridylethyl)-L-cysteine side chains.
Topics: Acetylation; Alanine; Amino Acids; Caseins; Cysteine; Indicators and Reagents; Pyridines | 1982 |
Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide.
Topics: Acrolein; Alanine; Animals; Body Weight; Carcinoma 256, Walker; Cyclophosphamide; Cysteine; Female; Glutathione; Hematuria; Infusions, Parenteral; Liver; Male; Mice; Rats; Time Factors | 1981 |
Decreased cysteine and proline synthesis in parenterally fed, premature infants.
Topics: Alanine; Amino Acids; Aspartic Acid; Birth Weight; Blood Glucose; Carbon Isotopes; Cysteine; Electrolytes; Energy Intake; Female; Food, Formulated; Gas Chromatography-Mass Spectrometry; Gestational Age; Glucose; Glutamic Acid; Glycine; Humans; Infant Food; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature; Lipids; Male; Parenteral Nutrition; Parenteral Nutrition Solutions; Proline; Serine; Solutions | 1995 |
Human class 1 aldehyde dehydrogenase. Expression and site-directed mutagenesis.
Topics: 2,2'-Dipyridyl; Alanine; Aldehyde Dehydrogenase; Cysteine; Disulfides; Humans; Mutagenesis, Site-Directed; Sulfhydryl Reagents | 1995 |
Use of protease sensitivity to probe the conformations of newly synthesised mutant forms of mitochondrial aspartate aminotransferase.
Topics: Alanine; Animals; Aspartate Aminotransferases; Cell-Free System; Cysteine; Kinetics; Mitochondria, Liver; Mutagenesis, Site-Directed; Plasmids; Point Mutation; Pronase; Protein Conformation; Rats; Recombinant Fusion Proteins; Serine; Tetrahydrofolate Dehydrogenase | 1995 |
Binding of phenylarsenoxide to Arg-tRNA protein transferase is independent of vicinal thiols.
Topics: Acyltransferases; Alanine; Aminoacyltransferases; Arsenicals; Base Sequence; Cysteine; DNA Primers; Iodine Radioisotopes; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Saccharomyces cerevisiae; Serine; Sulfhydryl Compounds | 1995 |
Formation of a hydrophobic cluster in denatured bovine pancreatic trypsin inhibitor.
Topics: Alanine; Amino Acid Sequence; Animals; Aprotinin; Cattle; Cloning, Molecular; Cysteine; Escherichia coli; Isoleucine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Protein Denaturation; Protein Folding; Tyrosine; Water | 1994 |
NMDA receptor channels: subunit-specific potentiation by reducing agents.
Topics: Alanine; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cysteine; Dithiothreitol; Drug Synergism; Ethylmaleimide; Glutamates; Glutamic Acid; Glutathione; Humans; Ion Channels; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Transfection | 1994 |
Formation of a native-like subdomain in a partially folded intermediate of bovine pancreatic trypsin inhibitor.
Topics: Alanine; Animals; Aprotinin; Cattle; Circular Dichroism; Cysteine; Disulfides; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Protein Folding; Recombinant Proteins | 1994 |
The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.
Topics: Alanine; Amino Acid Sequence; Bacterial Toxins; Base Sequence; Cyanobacteria; Cysteine; Humans; Iodine Radioisotopes; Isotope Labeling; Microcystins; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Binding; Protein Phosphatase 1 | 1995 |
Replacements of histidine 226 of NhaA-Na+/H+ antiporter of Escherichia coli. Cysteine (H226C) or serine (H226S) retain both normal activity and pH sensitivity, aspartate (H226D) shifts the pH profile toward basic pH, and alanine (H226A) inactivates the ca
Topics: Alanine; Aspartic Acid; Codon; Cysteine; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Phenotype; Point Mutation; Serine; Sodium-Hydrogen Exchangers | 1995 |
A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency.
Topics: Alanine; Aldehydes; Amino Acid Sequence; Animals; Cell Line; Conserved Sequence; Cysteine; DNA, Complementary; Fibroblasts; Humans; Lysosomal Storage Diseases; Molecular Sequence Data; Mutation; Sequence Homology, Amino Acid; Sulfatases | 1995 |
Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM.
Topics: Adult; Aged; Alanine; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cysteine; Diabetes Mellitus, Type 2; DNA; DNA Primers; Exons; Female; Genetic Linkage; Humans; Insulin; Japan; Kinetics; Macromolecular Substances; Male; Middle Aged; Molecular Sequence Data; Pedigree; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Polymerase Chain Reaction; Receptor, Insulin; Recombinant Proteins; Threonine; Transfection; Tyrosine | 1995 |
Cumulative effects of mutations in newly synthesised mitochondrial aspartate aminotransferase on uptake into mitochondria.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartate Aminotransferases; Cysteine; Kinetics; Mitochondria; Mutagenesis, Site-Directed; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; Serine | 1995 |
Disulfide bond mutations affect the folding of the human chorionic gonadotropin-beta subunit in transfected Chinese hamster ovary cells.
Topics: Alanine; Amino Acid Sequence; Animals; CHO Cells; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Cricetinae; Cysteine; Disulfides; Humans; Kinetics; Models, Structural; Mutagenesis, Site-Directed; Peptide Fragments; Protein Conformation; Protein Folding; Transfection | 1993 |
Production and characterization of an analog of acidic fibroblast growth factor with enhanced stability and biological activity.
Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Animals; Base Sequence; Biological Assay; Cell Division; Circular Dichroism; Cysteine; Escherichia coli; Fibroblast Growth Factor 1; Glycine; Histidine; Hot Temperature; Mice; Molecular Sequence Data; Mutation; Protein Denaturation; Protein Engineering; Recombinant Proteins; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1993 |
Uptake and receptor sites for glycine in isolated bovine adrenal medulla chromaffin cells.
Topics: Acetamides; Adrenal Medulla; Alanine; Animals; beta-Alanine; Cattle; Cell Membrane; Choline; Cysteine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Kinetics; Ouabain; Receptors, Glycine; Sarcosine; Sodium; Strychnine; Taurine; Temperature | 1993 |
Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca(2+)-binding EF-hand sequence.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Aorta; Binding Sites; Calcium; Capillaries; Cattle; Cell Division; Cells, Cultured; Cysteine; DNA; Dose-Response Relationship, Drug; Endothelium, Vascular; Fibroblast Growth Factor 2; Heparin; Isotope Labeling; Molecular Sequence Data; Osteonectin; Thymidine; Tritium | 1995 |
Electrospray-ionization mass spectrometry of molecular variants of a [2Fe-2S] ferredoxin.
Topics: Alanine; Apoproteins; Clostridium; Cysteine; Ferredoxins; Genetic Variation; Iron; Macromolecular Substances; Mass Spectrometry; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Serine; Sulfur | 1995 |
Identification of the reactive sulfhydryl group of 1-aminocyclopropane-1-carboxylate deaminase.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Amino Acids, Cyclic; Carbon-Carbon Lyases; Cysteine; Iodoacetamide; Lyases; Molecular Sequence Data; Naphthalenesulfonates; Protein Conformation; Pseudomonas; Spectrophotometry, Ultraviolet; Temperature | 1993 |
Crystallographic analyses of NADH peroxidase Cys42Ala and Cys42Ser mutants: active site structures, mechanistic implications, and an unusual environment of Arg 303.
Topics: Alanine; Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Mutation; Peroxidases; Protein Structure, Tertiary; Serine | 1995 |
Computer modelling of the alpha-helical coiled coil: packing of side-chains in the inner core.
Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Computer Simulation; Cysteine; Glutamates; Glutamine; Histidine; Hydrogen Bonding; Isoleucine; Leucine; Lysine; Methionine; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Serine; Thermodynamics; Threonine; Tyrosine; Valine | 1995 |
Mechanism of irreversible inactivation of phosphomannose isomerases by silver ions and flamazine.
Topics: Alanine; Antifungal Agents; Base Sequence; Candida albicans; Carbazoles; Cations, Monovalent; Cysteine; Dose-Response Relationship, Drug; Indoles; Mannose-6-Phosphate Isomerase; Mercuric Chloride; Molecular Sequence Data; Mutagenesis, Site-Directed; Organometallic Compounds; Silver; Silver Sulfadiazine | 1995 |
Evaluation of E test as a rapid method for determining MICs for nutritionally variant streptococci.
Topics: Agar; Alanine; Animals; Culture Media; Cysteine; Endocarditis, Bacterial; Horses; Humans; Indicator Dilution Techniques; Microbial Sensitivity Tests; Pyridoxine; Streptococcus; Sulfhydryl Compounds | 1994 |
MacMolecular: a program for visualization of molecular structures on the Macintosh.
Topics: Alanine; Computer Graphics; Cysteine; Microcomputers; Models, Molecular; Molecular Conformation; Peptides; Protein Conformation; Protein Structure, Secondary; Software | 1994 |
Tryptophanase from Escherichia coli: catalytic and spectral properties in water-organic solvents.
Topics: Alanine; Catalysis; Cysteine; Dimethylformamide; Escherichia coli; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Methanol; Pyridoxal Phosphate; Solutions; Spectrophotometry, Ultraviolet; Stereoisomerism; Substrate Specificity; Tryptophan; Tryptophanase; Water | 1994 |
Site-directed mutagenesis of vacuolar H(+)-pyrophosphatase. Necessity of Cys634 for inhibition by maleimides but not catalysis.
Topics: Alanine; Amino Acid Sequence; Arabidopsis; Base Sequence; Catalysis; Cysteine; DNA, Complementary; Ethylmaleimide; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrophosphatases; Saccharomyces cerevisiae; Serine; Vacuoles | 1995 |
Transcriptional activity of transcription factor IIE is dependent on zinc binding.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Cysteine; DNA-Binding Proteins; HeLa Cells; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Structure, Secondary; Recombinant Proteins; TATA Box; TATA-Box Binding Protein; Transcription Factor TFIIB; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Zinc; Zinc Fingers | 1994 |
Mutated forms of the [2Fe-2S] ferredoxin from Clostridium pasteurianum with noncysteinyl ligands to the iron-sulfur cluster.
Topics: Alanine; Base Sequence; Clostridium; Cysteine; DNA, Bacterial; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferredoxins; Iron; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Sulfur | 1994 |
Histidine ammonia-lyase mutant S143C is posttranslationally converted into fully active wild-type enzyme. Evidence for serine 143 to be the precursor of active site dehydroalanine.
Topics: Alanine; Base Sequence; Cysteine; Histidine Ammonia-Lyase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygen; Protein Precursors; Protein Processing, Post-Translational; Pseudomonas putida; Recombinant Proteins; Serine; Structure-Activity Relationship; Sulfhydryl Compounds; Threonine | 1994 |
The cooperative binding of chromosomal protein HMG-14 to nucleosome cores is reduced by single point mutations in the nucleosomal binding domain.
Topics: Alanine; Base Sequence; Binding Sites; Cysteine; Escherichia coli; Gene Expression; Glutamic Acid; High Mobility Group Proteins; Humans; Iodoacetamide; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleosomes; Point Mutation; Protein Conformation; Recombinant Proteins; Structure-Activity Relationship; Sulfhydryl Compounds | 1994 |
Cysteine-524 is not the only residue involved in the formation of disulphide-bonded dimers of the insulin receptor.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cricetinae; Cricetulus; Cysteine; Disulfides; DNA; DNA Primers; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Glucose; Humans; Insulin; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Receptor, Insulin; Signal Transduction; Transfection | 1994 |
Alteration of the substrate specificity of human lysozyme by site-specific intermolecular cross-linking.
Topics: Alanine; Arginine; Base Sequence; Carbohydrate Sequence; Chitin; Circular Dichroism; Cross-Linking Reagents; Cysteine; Glucosides; Humans; Maleimides; Models, Molecular; Molecular Sequence Data; Muramidase; Mutagenesis, Site-Directed; Mutation; Oligosaccharides; Osmolar Concentration; Protein Conformation; Structure-Activity Relationship; Substrate Specificity | 1994 |
Functional analysis of the cysteine residues of activin A.
Topics: Activins; Alanine; Amino Acid Sequence; Cell Line; Cysteine; Escherichia coli; Humans; Inhibins; Kidney; Molecular Sequence Data; Mutation; Protein Precursors; Transfection | 1994 |
The plasma amino acid response to cafeteria feeding and essential-amino acid gavage in weaning rats.
Topics: Alanine; Amino Acids; Amino Acids, Essential; Animals; Cysteine; Diet; Female; Food Services; Glutamates; Glutamic Acid; Glutamine; Glycine; Hydroxyproline; Methionine; Ornithine; Proline; Rats; Rats, Wistar | 1993 |
Functional expression of rat alpha 1 Na,K-ATPase containing substitutions for cysteines 454, 458, 459, 513 and 551.
Topics: Adenosine Triphosphate; Alanine; Animals; Blotting, Western; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Mutagenesis, Site-Directed; Mutation; Ouabain; Rats; Serine; Sodium-Potassium-Exchanging ATPase; Transfection | 1993 |
K-ras-2 topographic genotyping of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Alanine; Arginine; Aspartic Acid; Codon; Cysteine; DNA, Neoplasm; Exons; Forecasting; Genes, ras; Genotype; Glycine; Humans; Leucine; Mutation; Pancreas; Pancreatic Neoplasms; Serine; Survival Rate; Valine | 1994 |
Structure of a histidine-X4-histidine zinc finger domain: insights into ADR1-UAS1 protein-DNA recognition.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Cysteine; DNA; DNA-Binding Proteins; Histidine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Protein Conformation; Saccharomyces cerevisiae Proteins; Solutions; Transcription Factors; Zinc Fingers | 1994 |
Structure and function in rhodopsin: replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state.
Topics: Alanine; Amino Acid Sequence; Animals; Cattle; Cysteine; Disulfides; Guanine Nucleotides; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Denaturation; Recombinant Proteins; Rhodopsin; Rod Opsins; Structure-Activity Relationship; Temperature; Transducin | 1994 |
Intermolecular disulfide linkages are not required for transthyretin amyloid fibril formation in vitro.
Topics: Alanine; Amino Acid Sequence; Amyloid; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Macromolecular Substances; Microscopy, Electron; Mutagenesis, Site-Directed; Prealbumin; Protein Conformation; Recombinant Proteins | 1993 |
Conserved cysteine residues are critical for the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Conserved Sequence; Cysteine; DNA; Ethylmaleimide; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein-Tyrosine Kinases | 1993 |
Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.
Topics: Acylation; Alanine; Allosteric Regulation; Amino Acid Sequence; Animals; Cell Line; Chromatography, Affinity; Cysteine; Dogs; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kidney; Kinetics; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Receptors, Adrenergic, beta; Recombinant Proteins; Serine; Swine; Transfection; Yohimbine | 1993 |
Rapid kinetic measurements of second messenger formation in olfactory cilia from channel catfish.
Topics: Alanine; Amino Acids; Animals; Cilia; Cyclic AMP; Cyclic GMP; Cysteine; Epithelium; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Ictaluridae; Inositol 1,4,5-Trisphosphate; Kinetics; Olfactory Mucosa; Second Messenger Systems; Thionucleotides | 1993 |
The effects of site-directed mutagenesis on the dimerization and secretion of the NS1 protein specified by dengue virus.
Topics: Alanine; Animals; Base Sequence; Cysteine; Dengue Virus; DNA Mutational Analysis; Fluorescent Antibody Technique; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Simian virus 40; Structure-Activity Relationship; Transfection; Viral Nonstructural Proteins | 1993 |
Dynamics of protein relaxation in site-specific mutants of human myoglobin.
Topics: Alanine; Amino Acid Sequence; Cysteine; Heme; Humans; Kinetics; Mathematics; Mutagenesis, Site-Directed; Myoglobin; Protein Conformation; Recombinant Proteins; Spectrophotometry; Time Factors | 1993 |
Disulfide bond formation in the human immunodeficiency virus type 1 Nef protein.
Topics: Acquired Immunodeficiency Syndrome; Alanine; Alleles; Animals; Cell Line; Cysteine; Disulfides; Gene Products, nef; HIV-1; Humans; Mutagenesis, Site-Directed; nef Gene Products, Human Immunodeficiency Virus; T-Lymphocytes; Virus Replication | 1993 |
Active transport of L-proline in the protozoan parasite Trypanosoma brucei brucei.
Topics: Adenosine Triphosphate; Alanine; Animals; Azetidinecarboxylic Acid; Binding, Competitive; Biological Transport, Active; Cell Membrane Permeability; Cysteine; Digitonin; Hydrogen-Ion Concentration; Hydroxyproline; Iodoacetates; Iodoacetic Acid; Kinetics; Potassium Cyanide; Proline; Temperature; Thermodynamics; Trypanosoma brucei brucei | 1993 |
Intersubunit location of the active site of mammalian ornithine decarboxylase as determined by hybridization of site-directed mutants.
Topics: Alanine; Animals; Base Sequence; Binding Sites; Cysteine; Eflornithine; Lysine; Macromolecular Substances; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleic Acid Hybridization; Ornithine Decarboxylase; Pyridoxal Phosphate; Structure-Activity Relationship | 1993 |
Amino-acid-type-selective triple-resonance experiments.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Calcium-Binding Proteins; Carbon; Carrier Proteins; Cysteine; Glycine; Image Enhancement; Isoleucine; Magnetic Resonance Spectroscopy; Methionine; Microfilament Proteins; Nitrogen; Serine; Valine | 1996 |
Palmitoylation of the GluR6 kainate receptor.
Topics: Alanine; Animals; Autoradiography; Base Sequence; Cell Line; Cysteine; DNA, Complementary; Embryo, Mammalian; Embryo, Nonmammalian; GluK2 Kainate Receptor; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Open Reading Frames; Palmitic Acid; Palmitic Acids; Phosphorylation; Point Mutation; Protein Kinase C; Protein Processing, Post-Translational; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spodoptera; Transfection; Tritium | 1995 |
Topological mapping of the cysteine residues of N-carbamyl-D-amino-acid amidohydrolase and their role in enzymatic activity.
Topics: Alanine; Amidohydrolases; Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Cysteine; DNA Primers; Genes, Bacterial; Iodoacetates; Iodoacetic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Plasmids; Point Mutation; Recombinant Proteins; Restriction Mapping; Rhizobium; Serine | 1996 |
Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividans.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Anti-Bacterial Agents; Bacterial Proteins; Chromatography, Thin Layer; Cysteine; Electrophoresis, Polyacrylamide Gel; Mass Spectrometry; Molecular Sequence Data; Peptide Mapping; Protein Binding; Streptomyces; Thiostrepton; Trans-Activators | 1996 |
Escherichia coli contains a protein that is homologous in function and N-terminal sequence to the protein encoded by the nifS gene of Azotobacter vinelandii and that can participate in the synthesis of the Fe-S cluster of dihydroxy-acid dehydratase.
Topics: Alanine; Amino Acid Sequence; Azotobacter vinelandii; Bacterial Proteins; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Disulfides; Escherichia coli; Genes, Bacterial; Haemophilus influenzae; Hydro-Lyases; Iron-Sulfur Proteins; Kinetics; Macromolecular Substances; Molecular Sequence Data; Naphthalenesulfonates; Pantetheine; Peptide Fragments; Pyridoxal Phosphate; Sequence Homology, Amino Acid; Sulfhydryl Reagents | 1996 |
The functional role of the gamma-chain cysteine in Fc gamma RI-mediated phagocytosis using co-transfected COS-7 cells.
Topics: Alanine; Animals; Cell Line; Chlorocebus aethiops; Cysteine; Erythrocytes; Humans; Kidney; Mutagenesis, Site-Directed; Phagocytosis; Point Mutation; Polymerase Chain Reaction; Receptors, IgG; Recombinant Proteins; Sheep; Transfection | 1996 |
The evolutionary conservation of a novel protein modification, the conversion of cysteine to serinesemialdehyde in arylsulfatase from Volvox carteri.
Topics: Alanine; Aldehydes; Amino Acid Sequence; Arylsulfatases; Borohydrides; Chlorophyta; Chromatography, High Pressure Liquid; Conserved Sequence; Cysteine; Evolution, Molecular; Humans; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Sequence Analysis; Sequence Homology, Amino Acid; Trypsin | 1996 |
Nonprotein amino acids from seeds of Cycas circinalis and Phaseolus vulgaris.
Topics: Alanine; Amino Acids; Betaine; Cysteine; Dipeptides; Fabaceae; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Peptides; Pipecolic Acids; Plants, Medicinal; Seeds | 1996 |
Interaction of L-cysteine with a human excitatory amino acid transporter.
Topics: Alanine; Amino Acid Transport System X-AG; Animals; Binding, Competitive; Biological Transport, Active; Brain Chemistry; Carrier Proteins; Cysteine; Electrophysiology; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Kinetics; Oocytes; Patch-Clamp Techniques; Protons; Receptors, Neurotransmitter; Symporters; Xenopus laevis | 1996 |
1H-NMR and 13C-NMR investigation of complexes of Mn2+ with ocytocin analogues in (2H6)dimethylsulfoxide.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Carbon Isotopes; Cysteine; Deuterium; Dimethyl Sulfoxide; Glutamine; Hydrogen; Magnetic Resonance Spectroscopy; Manganese; Models, Molecular; Molecular Sequence Data; Oxytocin; Proline; Protein Binding; Protein Conformation; Sarcosine; Sulfhydryl Compounds; Thermodynamics; Threonine | 1996 |
Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.
Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Base Sequence; Benzoates; Binding Sites; Chromans; Cysteine; Humans; Kinetics; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Protein Biosynthesis; Rabbits; Receptors, Retinoic Acid; Reticulocytes; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Retinoids; Sequence Homology, Amino Acid; Transcription, Genetic; Transcriptional Activation; Tretinoin | 1996 |
Negative regulation of Raf-1 by phosphorylation of serine 621.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Chlorocebus aethiops; Cloning, Molecular; Consensus Sequence; COS Cells; Cysteine; Homeostasis; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Mapping; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Serine; Transfection | 1996 |
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein.
Topics: Adenosine Triphosphatases; Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Chromatography, Ion Exchange; Cloning, Molecular; Conserved Sequence; Cysteine; DNA Helicases; DNA Probes; Escherichia coli; Fungal Proteins; Glutamic Acid; Histidine; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; RNA Helicases; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Trans-Activators | 1996 |
Cysteine-191 in aspartate aminotransferases appears to be conserved due to the lack of a neutral mutation pathway to the functional equivalent, alanine-191.
Topics: Alanine; Amino Acid Sequence; Aspartate Aminotransferases; Conserved Sequence; Cysteine; Escherichia coli; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Denaturation; Structure-Activity Relationship; Urea | 1996 |
The masked cysteine residues in methylmalonyl-CoA mutase from Propionibacterium shermanii are essential for catalytic activity.
Topics: Alanine; Cloning, Molecular; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Methylmalonyl-CoA Mutase; Mutagenesis, Site-Directed; Propionibacterium; Protein Folding; Recombinant Proteins; Sulfhydryl Compounds | 1996 |
S- and C-glycopeptide derivatives of an LH-RH agonist.
Topics: Alanine; Animals; Buserelin; Carbohydrates; Cysteine; Female; Glycopeptides; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Ovulation; Protein Conformation; Rats; Structure-Activity Relationship | 1996 |
Yeast thiol-dependent protector protein expression enhances the resistance of Escherichia coli to hydrogen peroxide.
Topics: Alanine; Animals; Binding Sites; Blotting, Western; Catalase; Cell Death; Cell Division; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Escherichia coli; Fungal Proteins; Gene Expression Regulation, Bacterial; Hydrogen Peroxide; Isopropyl Thiogalactoside; Mutagenesis, Site-Directed; Neoplasm Proteins; Oxidants; Oxidation-Reduction; Oxidative Stress; Peroxidases; Peroxiredoxins; Proteins; Rabbits; Recombinant Proteins; Saccharomyces cerevisiae; Superoxide Dismutase | 1996 |
Identification of an active site cysteine residue in human type I Ins(1,4,5)P3 5-phosphatase by chemical modification and site-directed mutagenesis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Cattle; Circular Dichroism; Cysteine; Enzyme Inhibitors; Humans; Indicators and Reagents; Inositol Polyphosphate 5-Phosphatases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoric Monoester Hydrolases; Sequence Alignment; Serine; Substrate Specificity; Sulfhydryl Compounds | 1996 |
Characterization of rat monoamine oxidase A with noncovalently-bound FAD expressed in yeast cells.
Topics: Alanine; Animals; Cysteine; DNA, Complementary; Flavin-Adenine Dinucleotide; Kinetics; Kynuramine; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutagenesis, Site-Directed; Pargyline; Protein Binding; Rats; Saccharomyces cerevisiae; Serotonin; Substrate Specificity | 1996 |
A mutant metallothionein which has inverse fragment composition exhibits high cadmium-binding ability.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Cadmium; Cysteine; Escherichia coli; Humans; Metallothionein; Molecular Sequence Data; Point Mutation; Recombinant Proteins | 1997 |
Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97.
Topics: Alanine; beta Karyopherins; Binding Sites; Biological Transport; Cell Compartmentation; Cell Nucleus; Cysteine; GTP-Binding Proteins; Humans; Nuclear Proteins; Point Mutation; ran GTP-Binding Protein; Recombinant Proteins; Structure-Activity Relationship | 1997 |
Autophosphorylation-inactivation site of hexokinase 2 in Saccharomyces cerevisiae.
Topics: Alanine; Cysteine; Hexokinase; Phosphorylation; Point Mutation; Saccharomyces cerevisiae; Serine | 1997 |
Serine319 and 321 are functional in isocitrate lyase from Escherichia coli.
Topics: Alanine; Asparagine; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression Regulation, Bacterial; Glycine; Histidine; Isocitrate Lyase; Isocitrates; Kinetics; Magnesium; Mutagenesis, Site-Directed; Oligonucleotides; Plasmids; Proline; Sequence Alignment; Serine; Threonine | 1997 |
Yeast plasma-membrane H(+)-ATPase: the role of cysteine residues.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Chromosome Mapping; Cloning, Molecular; Cysteine; DNA, Fungal; Ethylmaleimide; Gene Expression Regulation, Fungal; Immunoblotting; Mutagenesis, Site-Directed; Proton Pumps; Proton-Translocating ATPases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1996 |
Cysteine-to-alanine replacements in the Escherichia coli SoxR protein and the role of the [2Fe-2S] centers in transcriptional activation.
Topics: Alanine; Bacterial Proteins; Base Sequence; beta-Galactosidase; Cysteine; DNA Primers; Electron Spin Resonance Spectroscopy; Escherichia coli; Iron-Sulfur Proteins; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Recombinant Fusion Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 1997 |
Substitutions of alanine for cysteine at a reactive thiol site and for lysine at a pyridoxal phosphate binding site of 1-aminocyclopropane-1-carboxylate deaminase.
Topics: Absorption; Alanine; Base Sequence; Binding Sites; Carbon-Carbon Lyases; Catalysis; Cysteine; Escherichia coli; Gene Expression Regulation, Enzymologic; Lyases; Lysine; Mutagenesis, Site-Directed; Mutation; Plasmids; Pyridoxal Phosphate; Spectrophotometry, Ultraviolet; Substrate Specificity; Sulfhydryl Compounds; Valine | 1997 |
Disulfide exchange folding of disulfide mutants of insulin-like growth factor I in vitro.
Topics: Alanine; Circular Dichroism; Cysteine; Disulfides; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Folding; Receptor, IGF Type 1 | 1997 |
Alteration of N-linked oligosaccharide structures of human chorionic gonadotropin beta-subunit by disruption of disulfide bonds.
Topics: Acetylglucosamine; Alanine; Animals; CHO Cells; Chorionic Gonadotropin, beta Subunit, Human; Chromatography, High Pressure Liquid; Cricetinae; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Galactose; Glycosylation; Humans; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mutation; Neuraminidase; Oligosaccharides; Protein Conformation; Tritium | 1997 |
Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acylation; Adenylyl Cyclases; Alanine; Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Cricetinae; Cysteine; Dopamine; Dopamine Agonists; GTP-Binding Proteins; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Radioligand Assay; Receptors, Adrenergic, beta-2; Receptors, Dopamine D1; Sequence Alignment; Software; Transfection | 1997 |
High-affinity binding of bioactive glycosylation-inhibiting factor to antigen-primed T cells and natural killer cells.
Topics: Alanine; Animals; Asparagine; Binding Sites; Cell Line; Cysteine; Escherichia coli; Humans; Hybridomas; Killer Cells, Natural; Kinetics; Lymphocyte Activation; Lymphokines; Macrophages; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Point Mutation; Prostatic Secretory Proteins; Recombinant Proteins; Serine; Suppressor Factors, Immunologic; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha | 1997 |
Biochemical studies on the toxicity of 1, 1'-dimethyl-4, 4'-bipyridylium dichloride in the rat.
Topics: Alanine; Analysis of Variance; Animals; Buthionine Sulfoximine; Cysteine; Herbicides; Lung; Male; Maleates; Microsomes; Microsomes, Liver; Paraquat; Rats; Rats, Wistar | 1997 |
NMR spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2. The carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Cell Line; Cysteine; DNA; DNA-Binding Proteins; Humans; Magnetic Resonance Spectroscopy; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Recombinant Fusion Proteins; Transfection; Zinc Fingers | 1997 |
A single mutation at the catalytic site of TF1-alpha3beta3gamma complex switches the kinetics of ATP hydrolysis from negative to positive cooperativity.
Topics: Adenosine Triphosphate; Alanine; Binding Sites; Catalysis; Cysteine; Dose-Response Relationship, Drug; Hydrolysis; Kinetics; Leucine; Mathematics; Mutation; Proton-Translocating ATPases; Tyrosine | 1997 |
Mutation of cysteine 111 in Dopa decarboxylase leads to active site perturbation.
Topics: 5-Hydroxytryptophan; Alanine; Animals; Base Sequence; Binding Sites; Circular Dichroism; Cysteine; Dopa Decarboxylase; Hydrogen-Ion Concentration; Kidney; Kinetics; Levodopa; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Spectrophotometry; Structure-Activity Relationship; Swine | 1997 |
A conserved cysteine residue in yeast uroporphyrinogen decarboxylase is not essential for enzymatic activity.
Topics: Alanine; Cysteine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Mutagenesis, Site-Directed; Plasmids; Saccharomyces cerevisiae; Serine; Transformation, Genetic; Uroporphyrinogen Decarboxylase | 1997 |
Covalent modification of the regulatory domain irreversibly stimulates cystic fibrosis transmembrane conductance regulator.
Topics: Adenosine Triphosphate; Alanine; Binding Sites; Cyclic AMP-Dependent Protein Kinases; Cysteine; Cystic Fibrosis Transmembrane Conductance Regulator; Cytoplasm; Ethylmaleimide; Humans; Models, Chemical; Mutagenesis, Site-Directed; Transfection | 1997 |
Conversion of cysteine to formylglycine: a protein modification in the endoplasmic reticulum.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Biological Transport; Cerebroside-Sulfatase; Cysteine; Endoplasmic Reticulum; Glycine; Humans; Lysosomal Storage Diseases; Molecular Sequence Data; Protein Biosynthesis; Protein Processing, Post-Translational | 1997 |
Simultaneous determination of urinary cystathionine, lanthionine, S-(2-aminoethyl)-L-cysteine and their cyclic compounds using liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization.
Topics: Alanine; Atmospheric Pressure; Chromatography, Ion Exchange; Cystathionine; Cysteine; Humans; Ions; Mass Spectrometry; Reference Values; Sulfides | 1997 |
A mutation in tomato aspermy cucumovirus that abolishes cell-to-cell movement is maintained to high levels in the viral RNA population by complementation.
Topics: Alanine; Cucumovirus; Cysteine; Genetic Complementation Test; Genetic Heterogeneity; Plant Viral Movement Proteins; Point Mutation; RNA, Viral; Solanum lycopersicum; Viral Proteins; Virus Replication | 1997 |
Site-directed mutagenesis of the Cys residues in ClpA, the ATPase component of protease Ti (ClpAP) in Escherichia coli.
Topics: Adenosine Triphosphatases; Alanine; Caseins; Cysteine; Electrophoresis, Polyacrylamide Gel; Endopeptidase Clp; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Mutagenesis, Site-Directed; Serine; Serine Endopeptidases; Sulfhydryl Reagents | 1997 |
The rat serotonin transporter: identification of cysteine residues important for substrate transport.
Topics: Alanine; Amino Acid Substitution; Animals; Carrier Proteins; Cell Line; Cell Membrane; Citalopram; Cysteine; Humans; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Conformation; Rats; Recombinant Proteins; Serine; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection | 1997 |
L-alanine uptake by frog (Rana esculenta) red blood cells.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Biological Transport, Active; Cysteine; Erythrocytes; Female; Fishes; In Vitro Techniques; Kinetics; Male; Mammals; Rana esculenta; Sodium | 1997 |
Replacement of Ala-166 with cysteine in the high affinity rabbit sodium/glucose transporter alters transport kinetics and allows methanethiosulfonate ethylamine to inhibit transporter function.
Topics: Alanine; Animals; Biological Transport; Cysteine; Ethyl Methanesulfonate; Kinetics; Membrane Glycoproteins; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Rabbits; Recombinant Proteins; Sodium-Glucose Transporter 1; Xenopus laevis | 1998 |
Effect of selective cysteine --> alanine replacements on the catalytic functions of lysine: N6-hydroxylase.
Topics: 2,6-Dichloroindophenol; Alanine; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cyanogen Bromide; Cysteine; Dithionitrobenzoic Acid; Flavoproteins; Iodoacetates; Iodoacetic Acid; Lysine; Mass Spectrometry; Mixed Function Oxygenases; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Peptide Fragments; Protein Conformation; Recombinant Proteins; Sequence Analysis; Trypsin | 1997 |
Esterification of 9-fluorenylmethoxycarbonyl-glycosylated serine and cysteine derivatives with an hydroxymethyl resin.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Cysteine; Dinitrobenzenes; Esterification; Fluorenes; Glycosylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Peptides; Resins, Plant; Serine; Stereoisomerism; Triazines | 1997 |
Cysteine 195 has a critical functional role in catalysis by isocitrate lyase from Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cysteine; Escherichia coli; Glycine; Isocitrate Lyase; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Sequence Alignment; Sequence Analysis; Sequence Homology, Amino Acid; Serine; Threonine; Valine | 1997 |
The effects of steric mutations on the structure of type III antifreeze protein and its interaction with ice.
Topics: Alanine; Amino Acid Substitution; Animals; Antifreeze Proteins, Type III; Crystallization; Crystallography, X-Ray; Cysteine; Eels; Ice; Methionine; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Secondary; Proteins; Stereoisomerism; Water | 1998 |
Two conformational states of beta-lactamase bound to GroEL: a biophysical characterization.
Topics: Alanine; beta-Lactamases; Chaperonin 60; Cysteine; Guanidine; Kinetics; Macromolecular Substances; Mass Spectrometry; Protein Conformation; Protein Denaturation; Protein Folding; Temperature | 1998 |
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cancer Vaccines; Cysteine; Cytotoxicity, Immunologic; HLA-A1 Antigen; Humans; Immunodominant Epitopes; Melanoma; Monophenol Monooxygenase; Peptide Fragments; Serine; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1998 |
Conversion of cysteine to formylglycine in eukaryotic sulfatases occurs by a common mechanism in the endoplasmic reticulum.
Topics: Alanine; Animals; Cell Line; Cerebroside-Sulfatase; Chondro-4-Sulfatase; Cricetinae; Cysteine; Endoplasmic Reticulum; Eukaryotic Cells; Glycine; Humans; Protein Processing, Post-Translational; Time Factors | 1998 |
Non-canonical inteins.
Topics: Adenosine Triphosphatases; Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Consensus Sequence; Conserved Sequence; Cyanobacteria; Cysteine; Databases as Topic; Methanococcus; Molecular Sequence Data; Open Reading Frames; Peptide Library; Protein Splicing; Sequence Alignment; Sequence Homology, Amino Acid; Serine | 1998 |
Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
Topics: Alanine; Alkaline Phosphatase; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Serine | 1998 |
An NMR investigation of the conformational effect of nitroxide spin labels on Ala-rich helical peptides.
Topics: Alanine; Circular Dichroism; Cyclic N-Oxides; Cysteine; Magnetic Resonance Spectroscopy; Mesylates; Peptides; Protein Structure, Secondary; Spin Labels | 1998 |
Discrepancies between the NMR and X-ray structures of uncomplexed barstar: analysis suggests that packing densities of protein structures determined by NMR are unreliable.
Topics: Alanine; Amino Acid Substitution; Bacillus; Bacterial Proteins; Crystallization; Crystallography, X-Ray; Cysteine; Dimerization; Macromolecular Substances; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Folding; Ribonucleases; Structure-Activity Relationship | 1998 |
Studies on cysteine residues involved in the active site of human cytidine deaminase.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Cloning, Organism; Cysteine; Cytidine Deaminase; Dimerization; Genetic Complementation Test; Humans; Kinetics; Mutagenesis, Site-Directed; Recombinant Proteins; Sulfhydryl Reagents; Zinc | 1998 |
Site-directed mutagenesis and chemical modification of the two cysteine residues of the UDP-N-acetylmuramoyl:L-alanine ligase of Escherichia coli.
Topics: Alanine; Alkylation; Cysteine; Enzyme Activation; Enzyme Stability; Escherichia coli; Ethylmaleimide; Mutagenesis, Site-Directed; Peptide Mapping; Peptide Synthases; Reducing Agents | 1998 |
Atomic force microscopy detects changes in the interaction forces between GroEL and substrate proteins.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Substitution; Chaperonin 60; Citrate (si)-Synthase; Cysteine; Escherichia coli; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Saccharomyces cerevisiae; Sensitivity and Specificity | 1998 |
Characteristics of L-alanine transport in cardiac sarcolemmal vesicles and into isolated cardiac myocytes.
Topics: Alanine; Animals; beta-Alanine; Biological Transport; Cysteine; Glutamine; In Vitro Techniques; Myocardium; Phenylalanine; Sarcolemma; Sheep; Sodium | 1998 |
Dimerization of P-selectin glycoprotein ligand-1 (PSGL-1) required for optimal recognition of P-selectin.
Topics: Alanine; Animals; Cell Adhesion; Cell Membrane; COS Cells; Cysteine; Dimerization; Fucosyltransferases; Humans; Ligands; Membrane Glycoproteins; N-Acetylglucosaminyltransferases; P-Selectin; Solubility; Tumor Cells, Cultured | 1998 |
Crystal structure of phosphate binding protein labeled with a coumarin fluorophore, a probe for inorganic phosphate.
Topics: Alanine; Amino Acid Substitution; Carrier Proteins; Computer Simulation; Coumarins; Crystallization; Crystallography, X-Ray; Cysteine; Escherichia coli; Fluorescent Dyes; Models, Molecular; Mutagenesis, Site-Directed; Phosphate-Binding Proteins; Phosphates; Stereoisomerism | 1998 |
Structure of the interhelical loops and carboxyl terminus of bacteriorhodopsin by X-ray diffraction using site-directed heavy-atom labeling.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Bacteriorhodopsins; Chloromercuribenzoates; Cysteine; Glycine; Isotope Labeling; Molecular Sequence Data; Mutagenesis, Site-Directed; Photochemistry; Protein Structure, Secondary; Proton Pumps; Spectrophotometry, Ultraviolet; Valine; X-Ray Diffraction | 1998 |
Functional significance of cysteine residues in the delta opioid receptor studied by site-directed mutagenesis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cysteine; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Receptors, Opioid, delta; Serine | 1998 |
Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Cysteine; Humans; Insulin; Insulin-Like Growth Factor I; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Receptor, IGF Type 1 | 1998 |
Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Topics: Alanine; Binding Sites; Circular Dichroism; Cysteine; Cysteine Synthase; Deuterium; Enzyme Activation; Enzyme Stability; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Insertional; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1998 |
Rapid reduction of Hg(II) by mercuric ion reductase does not require the conserved C-terminal cysteine pair using HgBr2 as the substrate.
Topics: Alanine; Bacillus; Binding Sites; Bromides; Catalysis; Conserved Sequence; Cysteine; Glutathione Reductase; Kinetics; Mercury Compounds; Models, Molecular; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Oxidoreductases; Peptide Fragments; Substrate Specificity | 1998 |
Mitochondrial DNA mutations and pathogenicity.
Topics: Alanine; Cysteine; DNA, Mitochondrial; Female; Fuchs' Endothelial Dystrophy; Glycine; Humans; Mutation; Threonine | 1998 |
Effects of the cys mutations on structure and function of the ATP-dependent HslVU protease in Escherichia coli. The Cys287 to Val mutation in HslU uncouples the ATP-dependent proteolysis by HslvU from ATP hydrolysis.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alanine; ATP-Dependent Proteases; Cysteine; Endopeptidases; Escherichia coli; Ethylmaleimide; Heat-Shock Proteins; Hydrolysis; Mutagenesis, Site-Directed; Protein Conformation; Serine; Serine Endopeptidases; Substrate Specificity; Valine | 1998 |
Differential roles for disulfide bonds in the structural integrity and biological activity of kappa-Bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist.
Topics: Alanine; Animals; Bungarotoxins; Circular Dichroism; Cysteine; Disulfides; Models, Molecular; Mutagenesis, Site-Directed; Neurons; Nicotinic Antagonists; Oocytes; Protein Folding; Protein Structure, Secondary; Xenopus laevis | 1998 |
Lattice models for proteins reveal multiple folding nuclei for nucleation-collapse mechanism.
Topics: Alanine; Amino Acid Sequence; Cysteine; Glycine; Kinetics; Models, Molecular; Molecular Sequence Data; Peptides; Plant Proteins; Point Mutation; Protein Folding; Proteins; Spectrin; Thermodynamics | 1998 |
Human serum, cysteine and histidine inhibit the oxidation of low density lipoprotein less at acidic pH.
Topics: Alanine; Antioxidants; Blood; Copper; Cysteine; Extracellular Space; Histidine; Humans; Hydrogen-Ion Concentration; Lipoproteins, LDL; Oxidation-Reduction | 1998 |
Posttranslational formation of formylglycine in prokaryotic sulfatases by modification of either cysteine or serine.
Topics: Alanine; Arylsulfatases; Bacterial Proteins; Binding Sites; Borohydrides; Cysteine; Glycine; Klebsiella pneumoniae; Mutagenesis, Site-Directed; Peptide Fragments; Prokaryotic Cells; Protein Processing, Post-Translational; Pseudomonas aeruginosa; Recombinant Proteins; Sequence Analysis; Serine; Sulfates; Trypsin | 1998 |
The five cysteine residues located in the active site region of bovine aspartyl (asparaginyl) beta-hydroxylase are not essential for catalysis.
Topics: Alanine; Animals; Binding Sites; Catalysis; Cattle; Cysteine; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Recombinant Proteins | 1998 |
Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry.
Topics: Alanine; Catalysis; Crystallization; Cysteine; Cysteine Synthase; Hydrogen-Ion Concentration; Microspectrophotometry; Models, Chemical; Salmonella typhimurium; Serine; Sodium Azide; Structure-Activity Relationship | 1998 |
An improved procedure for the preparation of X-ray diffraction-quality crystals of cytochrome p450cam.
Topics: Alanine; Amino Acid Substitution; Camphor 5-Monooxygenase; Cysteine; Point Mutation; Recombinant Proteins; X-Ray Diffraction | 1998 |
Role of the pro-alpha2(I) COOH-terminal region in assembly of type I collagen: disruption of two intramolecular disulfide bonds in pro-alpha2(I) blocks assembly of type I collagen.
Topics: Alanine; Animals; Base Sequence; Cell Line; Cloning, Molecular; Collagen; Cysteine; Dimerization; Disulfides; DNA Primers; Mice; Mutagenesis, Site-Directed; Protein Precursors; Protein Processing, Post-Translational | 1998 |
m-Calpain subunits remain associated in the presence of calcium.
Topics: Alanine; Animals; Calcium; Calpain; Caseins; Catalytic Domain; Cattle; Cysteine; Dimerization; Glutamic Acid; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Protein Binding; Recombinant Proteins; Serine | 1998 |
Protein engineering of BamHI restriction endonuclease: replacement of Cys54 by Ala enhances catalytic activity.
Topics: Alanine; Amino Acid Substitution; Bacillus; Bacteriophage lambda; Binding Sites; Catalysis; Catalytic Domain; Cysteine; Deoxyribonuclease BamHI; DNA; Escherichia coli; Kinetics; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Recombinant Proteins; Sequence Analysis, DNA; SOS Response, Genetics; Transformation, Bacterial | 1998 |
Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.
Topics: Alanine; Binding Sites; Circular Dichroism; Cysteine; Escherichia coli; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Glycine; Humans; Isoenzymes; Kinetics; Models, Molecular; Mutation; Protein Conformation; Recombinant Proteins; Spectrophotometry, Ultraviolet; Tryptophan | 1998 |
Conserved cysteines of the human immunodeficiency virus type 1 protease are involved in regulation of polyprotein processing and viral maturation of immature virions.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Conserved Sequence; COS Cells; Cysteine; Diamines; Dithiothreitol; Gene Products, gag; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Microtomy; Molecular Sequence Data; Oligopeptides; Protein Precursors; Protein Processing, Post-Translational; Proteins; Virion; Virus Assembly | 1999 |
Functional analysis of conserved cysteines in heparan sulfate N-deacetylase-N-sulfotransferases.
Topics: Alanine; Amidohydrolases; Amino Acid Substitution; Animals; Catalysis; Cysteine; Dithiothreitol; Enzyme Inhibitors; Ethylmaleimide; Hydrogen-Ion Concentration; Kinetics; Liver; Rats; Recombinant Proteins; Sulfotransferases | 1999 |
Functional consequences of a decreased potassium affinity in a potassium channel pore. Ion interactions and C-type inactivation.
Topics: Alanine; Animals; Cysteine; Electrophysiology; Kinetics; Membrane Potentials; Mice; Oocytes; Patch-Clamp Techniques; Potassium; Potassium Channels; Protein Conformation; Reverse Transcriptase Polymerase Chain Reaction; Shaker Superfamily of Potassium Channels; Sodium; Sodium Channel Blockers; Sodium Channels; Xenopus laevis | 1999 |
Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production.
Topics: Alanine; Amino Acid Substitution; Binding, Competitive; Cell Line; Cell Membrane; Conserved Sequence; Cyclic AMP; Cysteine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Secondary; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Receptors, Vasoactive Intestinal Polypeptide, Type I; Recombinant Proteins; Serine; Transfection; Vasoactive Intestinal Peptide | 1998 |
Variants of ribonuclease inhibitor that resist oxidation.
Topics: Alanine; Cysteine; Dose-Response Relationship, Drug; Escherichia coli; Humans; Hydrogen Peroxide; Models, Molecular; Oxygen; Protein Structure, Secondary; Ribonuclease, Pancreatic; Ribonucleases | 1999 |
Conformational unfolding studies of three-disulfide mutants of bovine pancreatic ribonuclease A and the coupling of proline isomerization to disulfide redox reactions.
Topics: Alanine; Amino Acid Substitution; Animals; Cattle; Cysteine; Disulfides; Mutagenesis, Site-Directed; Oxidation-Reduction; Proline; Protein Conformation; Protein Folding; Protein Isoforms; Ribonuclease, Pancreatic; Serine; Spectrometry, Fluorescence; Spectrophotometry | 1999 |
Rate-determining step of Escherichia coli alkaline phosphatase altered by the removal of a positive charge at the active center.
Topics: Alanine; Alkaline Phosphatase; Binding Sites; Cysteine; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Magnesium; Models, Molecular; Mutagenesis, Site-Directed; Phosphates | 1999 |
Thioredoxin reductase from Plasmodium falciparum: evidence for interaction between the C-terminal cysteine residues and the active site disulfide-dithiol.
Topics: Alanine; Animals; Binding Sites; Cysteine; Disulfides; Dithionite; Dithionitrobenzoic Acid; Kinetics; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Peptide Fragments; Plasmodium falciparum; Thioredoxin-Disulfide Reductase; Titrimetry; Toluene | 1999 |
Key role of barstar Cys-40 residue in the mechanism of heat denaturation of bacterial ribonuclease complexes with barstar.
Topics: Alanine; Bacillus; Bacterial Proteins; Cysteine; Endoribonucleases; Enzyme Stability; Heating; Mutagenesis, Site-Directed; Protein Denaturation; Ribonucleases | 1999 |
The cysteine-proximal aspartates in the Fx-binding niche of photosystem I. Effect of alanine and lysine replacements on photoautotrophic growth, electron transfer rates, single-turnover flash efficiency, and EPR spectral properties.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Binding Sites; Cyanobacteria; Cysteine; Electron Spin Resonance Spectroscopy; Electron Transport; Kinetics; Lysine; Membrane Proteins; Mutagenesis, Site-Directed; NADP; Photosynthetic Reaction Center Complex Proteins; Photosystem I Protein Complex; Structure-Activity Relationship | 1999 |
Glutamate regulates IP3-type and CICR stores in the avian cochlear nucleus.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alanine; Animals; Benzoates; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Chelating Agents; Chick Embryo; Cochlear Nucleus; Cyclic AMP; Cycloleucine; Cysteine; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Gallic Acid; Glutamic Acid; Glycine; Ibotenic Acid; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Receptors, Cytoplasmic and Nuclear; Ryanodine; Second Messenger Systems; Thionucleotides | 1999 |
Sequence determinants directing conversion of cysteine to formylglycine in eukaryotic sulfatases.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Catalytic Domain; Cerebroside-Sulfatase; Cysteine; DNA Primers; Glycine; Molecular Sequence Data; Mutagenesis, Site-Directed; Sequence Homology, Amino Acid | 1999 |
Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Carbachol; Cell Membrane; Conserved Sequence; COS Cells; Cysteine; Disulfides; GTP-Binding Proteins; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Phosphatidylinositols; Protein Structure, Secondary; Radioligand Assay; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Transfection; Tritium | 1999 |
Electric fields in active sites: substrate switching from null to strong fields in thiol- and selenol-subtilisins.
Topics: Acylation; Alanine; Amino Acid Substitution; Asparagine; Binding Sites; Crystallography, X-Ray; Cysteine; Esters; Glycine; Kinetics; Models, Molecular; Proline; Protein Conformation; Selenocysteine; Spectrum Analysis, Raman; Static Electricity; Substrate Specificity; Subtilisins | 1999 |
Site-directed mutagenesis of the cysteine ligands to the [4Fe-4S] cluster of Escherichia coli MutY.
Topics: Alanine; Cell Fractionation; Cysteine; DNA Glycosylases; DNA Repair; DNA, Bacterial; Enzyme Activation; Enzyme Stability; Escherichia coli; Histidine; Iron-Sulfur Proteins; Ligands; Models, Molecular; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Protein Binding; Recombinant Proteins; Serine | 1999 |
Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase.
Topics: Acylation; Adenosine Triphosphate; Alanine; Amino Acids; Cysteine; Escherichia coli; Homocysteine; Hydrolysis; Lactams; Leucine; Lysine-tRNA Ligase; Methionine; Ornithine; RNA Editing; RNA, Transfer, Lys; Threonine | 1999 |
Aminoethylcysteine can replace the function of the essential active site lysine of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Catalysis; Cysteine; Enzyme Activation; Hydroxymethylglutaryl CoA Reductases; Iodoacetamide; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Pseudomonas | 1999 |
A spectroscopic and calorimetric investigation on the thermal stability of the Cys3Ala/Cys26Ala azurin mutant.
Topics: Alanine; Azurin; Base Sequence; Calorimetry, Differential Scanning; Circular Dichroism; Cysteine; DNA Primers; Drug Stability; Electron Spin Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Spectrophotometry; Thermodynamics | 1999 |
Tryptophan mediated photoreduction of disulfide bond causes unusual fluorescence behaviour of Fusarium solani pisi cutinase.
Topics: Alanine; Amides; Carboxylic Ester Hydrolases; Cysteine; Disulfides; Fluorescence; Fusarium; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Sulfhydryl Compounds; Sulfhydryl Reagents; Tryptophan | 1999 |
Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Conserved Sequence; Cysteine; DNA Ligase ATP; DNA Ligases; DNA Mutational Analysis; DNA Repair; Escherichia coli; Genetic Complementation Test; Ligases; Methyl Methanesulfonate; Molecular Sequence Data; Mutagens; Saccharomyces cerevisiae; Structure-Activity Relationship; Ultraviolet Rays; Viral Proteins | 1999 |
Identification of two serine residues involved in catalysis by fatty acid amide hydrolase.
Topics: Alanine; Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Catalysis; COS Cells; Cysteine; Isoflurophate; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phospholipases A; Protease Inhibitors; Serine; Sulfhydryl Compounds | 1999 |
Streptolysin O: inhibition of the conformational change during membrane binding of the monomer prevents oligomerization and pore formation.
Topics: Alanine; Allosteric Regulation; Animals; Asparagine; Bacterial Proteins; Cysteine; Erythrocyte Membrane; Glutamic Acid; Lipid Bilayers; Membrane Proteins; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Conformation; Rabbits; Sheep; Spectrometry, Fluorescence; Streptolysins; Temperature | 1999 |
Yap1p activates gene transcription in an oxidant-specific fashion.
Topics: Alanine; Binding Sites; Cysteine; Diamide; DNA-Binding Proteins; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Reporter; Hydrogen Peroxide; Membrane Proteins; Mutagenesis; Oxidants; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thioredoxins; Transcription Factors; Transcription, Genetic | 1999 |
Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus.
Topics: Alanine; Anti-HIV Agents; Computer Simulation; Cysteine; Drug Design; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Pyridines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiourea; Tyrosine; Valine | 1999 |
Preference of Cd(II) and Zn(II) for the two metal sites in Bacillus cereus beta-lactamase II: A perturbed angular correlation of gamma-rays spectroscopic study.
Topics: Alanine; Amino Acid Substitution; Bacillus cereus; Binding Sites; Cadmium; Cations, Divalent; Cephalosporinase; Cephalosporins; Cysteine; Gamma Rays; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Sodium Chloride; Solutions; Spectrum Analysis; X-Ray Diffraction; Zinc | 1999 |
Cysteine 111 affects coupling of single-stranded DNA binding to ATP hydrolysis in the herpes simplex virus type-1 origin-binding protein.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Cysteine; Dithiothreitol; DNA Helicases; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Ethylmaleimide; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Sequence Homology, Amino Acid; Viral Proteins | 2000 |
Time-resolved site-directed spin-labeling studies of bacteriorhodopsin: loop-specific conformational changes in M.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Bacteriorhodopsins; Cysteine; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Kinetics; Mesylates; Molecular Sequence Data; Mutagenesis, Site-Directed; Photolysis; Protein Conformation; Protein Structure, Secondary; Purple Membrane; Spectrophotometry, Ultraviolet; Spin Labels | 2000 |
Inactivation of cysteine proteases by peptidyl epoxides: characterization of the alkylation sites on the enzyme and the inactivator.
Topics: Acids; Alanine; Alkylation; Cysteine; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Epoxy Compounds; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; Papain; Phenylalanine; Sulfhydryl Compounds | 2000 |
Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Cysteine; Glutamic Acid; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Threonine | 2000 |
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Cells, Cultured; Cycloheximide; Cysteine; Cysteine Endopeptidases; Down-Regulation; Humans; Indicators and Reagents; Iodide Peroxidase; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis; Plasmids; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Selenium Radioisotopes; Thyroxine; Transfection; Triiodothyronine, Reverse | 2000 |
Single-turnover kinetic analysis of Trypanosoma cruzi S-adenosylmethionine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Alanine; Animals; Binding Sites; Catalysis; Cysteine; Decarboxylation; Deuterium Oxide; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Putrescine; Schiff Bases; Trypanosoma cruzi | 2000 |
Oxidation-reduction properties of the regulatory disulfides of sorghum chloroplast nicotinamide adenine dinucleotide phosphate-malate dehydrogenase.
Topics: Alanine; Chloroplasts; Cysteine; Disulfides; Edible Grain; Enzyme Activation; Hydrogen-Ion Concentration; Malate Dehydrogenase; Malate Dehydrogenase (NADP+); Mutagenesis, Site-Directed; Oxidation-Reduction; Recombinant Proteins; Titrimetry | 2000 |
Selected cysteine residues in transmembrane domains of mu-opioid receptor are critical for effects of sulfhydryl reagents.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; CHO Cells; COS Cells; Cricetinae; Cysteine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethyl Methanesulfonate; Humans; Ligands; Membranes; Mesylates; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, mu; Sulfhydryl Reagents | 2000 |
Cystine knot mutations affect the folding of the glycoprotein hormone alpha-subunit. Differential secretion and assembly of partially folded intermediates.
Topics: Alanine; Amino Acid Substitution; Cell Line; Cysteine; Cystine; Disulfides; Dithiothreitol; Glycoprotein Hormones, alpha Subunit; Humans; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Folding; Protein Structure, Secondary; Recombinant Proteins; Transfection | 2000 |
Possible interference between tissue-non-specific alkaline phosphatase with an Arg54-->Cys substitution and acounterpart with an Asp277-->Ala substitution found in a compound heterozygote associated with severe hypophosphatasia.
Topics: Alanine; Alkaline Phosphatase; Amino Acid Substitution; Animals; Arginine; Aspartic Acid; COS Cells; Cysteine; DNA, Complementary; Heterozygote; Hypophosphatasia; Mutation, Missense; Transfection | 2000 |
Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1.
Topics: Alanine; Amino Acid Substitution; Animals; Arginine; Cell Line; Cysteine; Dimerization; Female; Glutamic Acid; In Vitro Techniques; Kinetics; Ligands; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spodoptera; Transfection; Xenopus laevis | 2000 |
A structure-function study of a proton transport pathway in the gamma-class carbonic anhydrase from Methanosarcina thermophila.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Biological Transport; Carbonic Anhydrases; Cysteine; Deuterium; Escherichia coli; Genetic Variation; Glutamic Acid; Glutamine; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Methanosarcina; Mutagenesis, Site-Directed; Protons; Serine; Solvents; Structure-Activity Relationship; Threonine; Tryptophan | 2000 |
Identification of copper ligands in Aspergillus oryzae tyrosinase by site-directed mutagenesis.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspergillus oryzae; Binding Sites; Blotting, Western; Catalysis; Circular Dichroism; Copper; Cysteine; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Ligands; Molecular Sequence Data; Monophenol Monooxygenase; Mutagenesis, Site-Directed; Nitrogen; Oxygenases; Peroxidases; Protein Binding; Recombinant Fusion Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Spectrophotometry, Atomic; Sulfur; Thioredoxins | 2000 |
Serine 121 is an essential amino acid for biotin sulfoxide reductase functionality.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Binding Sites; Biotin; Catalysis; Chromatography, High Pressure Liquid; Coenzymes; Conserved Sequence; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Factor Xa; Glutathione Transferase; Guanine Nucleotides; Iron-Sulfur Proteins; Ligands; Mass Spectrometry; Metalloproteins; Molecular Sequence Data; Molybdenum Cofactors; Mutagenesis, Site-Directed; NADP; Oxidative Stress; Oxidoreductases; Oxygen; Paraquat; Pteridines; Pterins; Recombinant Fusion Proteins; Rhodobacter sphaeroides; Sequence Homology, Amino Acid; Serine; Spectrometry, Fluorescence; Threonine; Time Factors | 2000 |
Mechanism of phosphoanhydride cleavage by baculovirus phosphatase.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Baculoviridae; Catalysis; Cloning, Molecular; Cysteine; DNA Mutational Analysis; Dose-Response Relationship, Drug; Escherichia coli; Humans; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Organophosphates; Oxygen; Phosphoric Monoester Hydrolases; Phosphorus; Plasmids; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship; Temperature; Time Factors; Transformation, Genetic | 2000 |
Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: N-ethylmaleimide-sensitive face of helix II.
Topics: Alanine; Amino Acid Sequence; Cold Temperature; Cysteine; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Glycine; Hot Temperature; Leucine; Membrane Proteins; Membrane Transport Modulators; Membrane Transport Proteins; Mesylates; Models, Molecular; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Periplasm; Protein Structure, Secondary; Solvents; Sulfhydryl Reagents; Symporters | 2000 |
Synthetic null-cysteine phospholamban analogue and the corresponding transmembrane domain inhibit the Ca-ATPase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cysteine; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Lipid Bilayers; Membrane Proteins; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Phosphatidylcholines; Protein Structure, Tertiary; Structure-Activity Relationship | 2000 |
Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Conserved Sequence; Cysteine; Disulfides; Endoplasmic Reticulum; Gene Deletion; Genetic Complementation Test; Genotype; Glycoproteins; Humans; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Phenotype; Protein Folding; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2000 |
Altering the reaction specificity of eukaryotic ornithine decarboxylase.
Topics: Alanine; Animals; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Cysteine; Decarboxylation; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Ornithine Decarboxylase; Putrescine; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substrate Specificity; Trypanosoma brucei brucei | 2000 |
An alternative protein splicing mechanism for inteins lacking an N-terminal nucleophile.
Topics: Alanine; Alternative Splicing; Bacterial Proteins; Carrier Proteins; Catalysis; Cell Line; Cloning, Molecular; Cysteine; Methanococcus; Models, Genetic; Mutagenesis, Site-Directed; Mutation; Polymorphism, Genetic; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Serine | 2000 |
Contribution of individual disulfide bonds to the oxidative folding of ribonuclease A.
Topics: Alanine; Animals; Cattle; Cysteine; Disulfides; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Protein Folding; Recombinant Proteins; Ribonuclease, Pancreatic; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2000 |
The role of cysteine residues in tellurite resistance mediated by the TehAB determinant.
Topics: Alanine; Alkylating Agents; Bacterial Proteins; Binding Sites; Cysteine; Dithionitrobenzoic Acid; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Iodoacetamide; Iodoacetates; Ligands; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Phenotype; Plasmids; Protein Binding; Protein Conformation; Protein Denaturation; S-Adenosylmethionine; Sulfhydryl Reagents; Tellurium; Up-Regulation | 2000 |
Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: redox independent functions.
Topics: Alanine; Bacterial Proteins; Catalysis; Cyclic N-Oxides; Cysteine; Diuretics, Osmotic; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radical Scavengers; Humans; Hydroxyl Radical; Indicators and Reagents; Kinetics; Mannitol; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidative Stress; Oxygen; Reactive Oxygen Species; Superoxides; Thioredoxins; Thiourea; Time Factors | 2000 |
Structure-function study and anti-HIV activity of synthetic peptide analogues derived from viral chemokine vMIP-II.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Anti-HIV Agents; Cell Line; Chemokines; Cysteine; Cytopathogenic Effect, Viral; Giant Cells; Glycine; HIV-1; Humans; Molecular Sequence Data; Peptide Fragments; Peptides; Phenylalanine; Protein Conformation; Receptors, CXCR4; Solutions; Structure-Activity Relationship; Virus Replication | 2000 |
Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; COS Cells; Cysteine; Disulfides; Dithiothreitol; Molecular Sequence Data; Mutation; Protein Conformation; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins | 2000 |
Serine and alanine mutagenesis of the nine native cysteine residues of the human A(1) adenosine receptor.
Topics: Alanine; Amino Acid Sequence; Cells, Cultured; Cysteine; Humans; Molecular Sequence Data; Mutagenesis; Protein Conformation; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Serine; Transfection; Tritium; Xanthines | 2000 |
Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Binding, Competitive; Blood-Brain Barrier; Brain Neoplasms; Cysteine; Glioblastoma; Humans; Iodine Radioisotopes; Isoquinolines; Male; Methyltyrosines; Neoplasm Transplantation; Phenylalanine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serine; Tetrahydroisoquinolines; Tomography, Emission-Computed, Single-Photon; Tumor Cells, Cultured | 2000 |
Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue.
Topics: Adenosine; Alanine; Cysteine; Cytosine; Deamination; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; Enzyme Inhibitors; Escherichia coli; Mutagenesis, Site-Directed; S-Adenosylmethionine; Serine; Uracil | 2000 |
Zinc release from the CH2C6 zinc finger domain of FILAMENTOUS FLOWER protein from Arabidopsis thaliana induces self-assembly.
Topics: Alanine; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Chelating Agents; Chromatography, Gel; Circular Dichroism; Cysteine; Edetic Acid; Gene Deletion; Genetic Vectors; Glutathione Transferase; Histidine; Leucine; Ligands; Molecular Sequence Data; Mutation; Plant Proteins; Plasmids; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sulfhydryl Compounds; Time Factors; Transcription, Genetic; Zinc; Zinc Fingers | 2001 |
Redox properties and coordination structure of the heme in the co-sensing transcriptional activator CooA.
Topics: Alanine; Bacterial Proteins; Cysteine; Electrochemistry; Escherichia coli Proteins; Fimbriae Proteins; Heme; Histidine; Iron; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Spectrum Analysis, Raman; Transcriptional Activation | 2001 |
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase.
Topics: Alanine; Catalysis; Cell Line; Cysteine; Gene Expression; Humans; Iodide Peroxidase; Iodine Radioisotopes; Kinetics; Mutagenesis; Recombinant Proteins; Selenocysteine; Structure-Activity Relationship; Thyroxine; Transfection; Triiodothyronine | 2000 |
The effects of cysteine to alanine mutations of CD18 on the expression and adhesion of the CD11/CD18 integrins.
Topics: Alanine; Animals; CD18 Antigens; Cell Adhesion; Chlorocebus aethiops; COS Cells; Cysteine; Gene Expression; Genetic Variation; Integrin alphaXbeta2; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Mutagenesis, Site-Directed; Transfection | 2000 |
Identification of active site residues in E. coli ketopantoate reductase by mutagenesis and chemical rescue.
Topics: Acetic Acid; Alanine; Alcohol Oxidoreductases; Alkylation; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Cysteine; Deuterium; Escherichia coli; Formates; Gene Expression Regulation, Bacterial; Glutamic Acid; Kinetics; Lysine; Molecular Sequence Data; Pantothenic Acid; Recombinant Proteins; Sequence Alignment; Substrate Specificity | 2000 |
Novel mutations in the GALK1 gene in patients with galactokinase deficiency.
Topics: Adolescent; Adult; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Child, Preschool; Cysteine; Female; Galactokinase; Galactosemias; Humans; Male; Methionine; Mice; Molecular Sequence Data; Mutation; Proline; Sequence Deletion; Threonine | 2001 |
Second mutations rescue point mutant of the Na(+)/H(+) exchanger NHE1 showing defective surface expression.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Cell Line; Cell Membrane; Cysteine; Mammals; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Sodium; Sodium-Hydrogen Exchangers; Transfection; Tyrosine | 2000 |
Assembly of cytochrome f into the cytochrome bf complex in isolated pea chloroplasts.
Topics: Alanine; Amino Acids; Brassica; Chloroplasts; Cysteine; Cytochrome b Group; Cytochrome b6f Complex; Cytochromes; Cytochromes f; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Mutagenesis, Site-Directed; Mutation; Pisum sativum; Protein Binding; Protein Biosynthesis; Protein Precursors; Ribulose-Bisphosphate Carboxylase; Subcellular Fractions; Thylakoids; Time Factors; Transcription, Genetic | 2001 |
Electrogenic Na(+)-dependent L-alanine transport in the lizard duodenum. Involvement of systems A and ASC.
Topics: Alanine; Animals; beta-Alanine; Biological Transport; Carrier Proteins; Cysteine; Duodenum; Electric Conductivity; Epithelium; Intestinal Mucosa; Kinetics; Lizards; Membrane Potentials; Serine; Sodium | 2001 |
Cysteinylation of MHC class II ligands: peptide endocytosis and reduction within APC influences T cell recognition.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antigen Presentation; Antigen-Presenting Cells; B-Lymphocytes; Cell Line; Coculture Techniques; Cysteine; Cystine; Endocytosis; HLA-D Antigens; Humans; Hybridomas; Hydrogen-Ion Concentration; Immunodominant Epitopes; Immunoglobulin kappa-Chains; Ligands; Mice; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Protein Binding; T-Lymphocytes | 2001 |
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation.
Topics: Alanine; Alkylation; Animals; Cysteine; DNA Damage; DNA Topoisomerases, Type II; Drosophila; Humans; Intercalating Agents; KB Cells; Mutagenesis, Site-Directed; Naphthoquinones; Quinones; Sulfhydryl Compounds; Tumor Cells, Cultured; Vitamin K | 2001 |
Inactivation of pyruvate formate-lyase by dioxygen: defining the mechanistic interplay of glycine 734 and cysteine 419 by rapid freeze-quench EPR.
Topics: Acetylation; Acetyltransferases; Alanine; Cysteine; Electron Spin Resonance Spectroscopy; Enzyme Activation; Escherichia coli; Free Radicals; Freezing; Glycine; Mutagenesis, Site-Directed; Oxygen; Peroxides; Serine | 2001 |
Mechanism underlying slow kinetics of the OFF gating current in Shaker potassium channel.
Topics: Alanine; Cations; Cell Line; Cysteine; Humans; Ions; Kinetics; Leucine; Meglumine; Models, Biological; Mutation; Potassium Channels; Shaker Superfamily of Potassium Channels; Tetraethylammonium; Transfection | 2001 |
Consequences of a modified putative substrate-activation site on catalysis by yeast pyruvate decarboxylase.
Topics: Alanine; Catalysis; Cysteine; Deuterium Oxide; Enzyme Activation; Hydrogen; Kinetics; Models, Chemical; Pyruvate Decarboxylase; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Solvents; Substrate Specificity; Thiamine Pyrophosphate; Thiazoles | 2001 |
Organization of the multiple coenzymes and subunits and role of the covalent flavin link in the complex heterotetrameric sarcosine oxidase.
Topics: Acetates; Alanine; Arthrobacter; Asparagine; Coenzymes; Corynebacterium; Cysteine; Enzyme Stability; Flavin Mononucleotide; Flavins; Gene Expression Regulation, Bacterial; Glycine; Histidine; Macromolecular Substances; Mutagenesis, Site-Directed; Oxidoreductases, N-Demethylating; Pseudomonas; Recombinant Proteins; Sarcosine Oxidase; Sulfites; Valine | 2001 |
Biochemical characterization and identification of catalytic residues in alpha-glucuronidase from Bacillus stearothermophilus T-6.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Binding Sites; Calorimetry, Differential Scanning; Catalysis; Catalytic Domain; Chromatography, Gel; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Geobacillus stearothermophilus; Glutamic Acid; Glycoside Hydrolases; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Temperature; Trioses | 2001 |
Development and evaluation of a boronate inhibitor of gamma-glutamyl transpeptidase.
Topics: Alanine; Alanine Transaminase; Aminobutyrates; Animals; Aspartate Aminotransferases; Binding Sites; Boron Compounds; Carbon Isotopes; Cell Division; Cell Line; Culture Media; Cysteine; gamma-Glutamyltransferase; Glutamine; Hydrogen-Ion Concentration; Kinetics; Liver; Magnetic Resonance Spectroscopy; Oxaloacetic Acid; Protons; Pyruvic Acid; Rats | 2001 |
Mutation of cysteine-295 to alanine in secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus affects the enantioselectivity and substrate specificity of ketone reductions.
Topics: Alanine; Alcohol Dehydrogenase; Amino Acid Sequence; Amino Acid Substitution; Bacillus; Base Sequence; Crystallography, X-Ray; Cysteine; DNA Primers; Ketones; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Sequence Homology, Amino Acid; Stereoisomerism; Substrate Specificity | 2001 |
Studies on analogs of a peptide derived from alpha-fetoprotein having antigrowth properties.
Topics: Alanine; alpha-Fetoproteins; Animals; Antineoplastic Agents; Chromatography, Gel; Cysteine; Dose-Response Relationship, Drug; Epitopes; Estrogens; Female; Glycine; Humans; Hydrogen-Ion Concentration; Mice; Peptides; Protein Structure, Secondary; Serine; Time Factors; Uterus | 2001 |
The role of the cysteine residues of ThiI in the generation of 4-thiouridine in tRNA.
Topics: Alanine; Amino Acid Motifs; Bacterial Proteins; Carbon-Sulfur Lyases; Cloning, Molecular; Cysteine; Disulfides; Dithionitrobenzoic Acid; Escherichia coli; Escherichia coli Proteins; Iron; Models, Chemical; Mutagenesis, Site-Directed; Plasmids; RNA, Transfer; Spectrophotometry; Sulfur; Sulfurtransferases; Thiamine; Thiouridine; Time Factors; Ultraviolet Rays; Uracil | 2001 |
Mutagenesis of beta-tubulin cysteine residues in Saccharomyces cerevisiae: mutation of cysteine 354 results in cold-stable microtubules.
Topics: Alanine; Benomyl; Cold Temperature; Cysteine; Fungal Proteins; Fungicides, Industrial; Microtubules; Mutagenesis, Site-Directed; Protein Structure, Secondary; Saccharomyces cerevisiae; Serine; Tubulin | 2001 |
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; Crystallography, X-Ray; Cysteine; Frizzled Receptors; Humans; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Sequence Alignment; Signal Transduction; Wnt Proteins; Xenopus; Xenopus Proteins; Zebrafish Proteins | 2001 |
Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine.
Topics: Alanine; Benzylamines; Chromatography, Liquid; Cyclopropanes; Cysteine; Enzyme Activation; Enzyme Inhibitors; Flavin Mononucleotide; Monoamine Oxidase Inhibitors; Mutagenesis, Site-Directed; Oxidoreductases, N-Demethylating; Phenylhydrazines; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2001 |
NAD+-dependent DNA ligase encoded by a eukaryotic virus.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Base Sequence; Catalysis; Cysteine; DNA Ligases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Evolution, Molecular; Gene Deletion; Genetic Vectors; Models, Biological; Molecular Sequence Data; Mutation; NAD; Phylogeny; Poxviridae; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Time Factors; Tyrosine; Zinc; Zinc Fingers | 2001 |
Cysteine substitutions reveal dual functions of the amino-terminal tail in cystic fibrosis transmembrane conductance regulator channel gating.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Alanine; Animals; Cysteine; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Indicators and Reagents; Ion Channel Gating; Mesylates; Xenopus | 2001 |
Stabilization of cauliflower mosaic virus P3 tetramer by covalent linkage.
Topics: Alanine; Amino Acid Sequence; Animals; Aphids; Base Sequence; Brassica; Caulimovirus; Cell Fractionation; Centrifugation, Density Gradient; Cloning, Molecular; Cysteine; DNA Replication; DNA, Viral; Molecular Sequence Data; Mutation; Plant Diseases; Plant Leaves; Viral Proteins; Virus Assembly; Virus Replication | 2001 |
Role of cysteine residues in structural stability and function of a transmembrane helix bundle.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Aminobutyrates; Animals; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cell Membrane; Cysteine; Detergents; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorenes; Kinetics; Lysophospholipase; Models, Molecular; Molecular Sequence Data; Muscle Fibers, Fast-Twitch; Muscle, Skeletal; Peptide Biosynthesis; Protein Conformation; Protein Structure, Tertiary; Rabbits; Sarcoplasmic Reticulum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature | 2001 |
Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cell Line; Cysteine; Disulfides; Humans; Hypothalamic Hormones; Isomerism; Melanins; Molecular Sequence Data; Peptide Fragments; Peptides, Cyclic; Pituitary Hormones; Protein Conformation; Receptors, G-Protein-Coupled; Receptors, Pituitary Hormone | 2001 |
Structural heterogeneity of blue copper proteins: an EPR study of amicyanin and of wild-type and Cys3Ala/Cys26Ala mutant azurin.
Topics: Alanine; Azurin; Bacterial Proteins; Copper; Cysteine; Electron Spin Resonance Spectroscopy; Metalloproteins; Models, Statistical; Mutation; Protein Conformation | 2001 |
Changes in mate recognition through alterations of pheromones and receptors in the multisexual mushroom fungus Schizophyllum commune.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Blotting, Southern; Cell Membrane; Cell Nucleus; Chemoreceptor Cells; Cysteine; DNA; Gene Library; Genes, Fungal; Genes, Mating Type, Fungal; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Pheromones; Polymerase Chain Reaction; Reproduction; Schizophyllum; Sequence Homology, Amino Acid | 2001 |
The structure and domain organization of Escherichia coli isocitrate lyase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Aspergillus nidulans; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Escherichia coli; Isocitrate Lyase; Models, Molecular; Molecular Sequence Data; Phosphopyruvate Hydratase; Protein Conformation; Protein Folding; Protein Structure, Quaternary; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2001 |
Characterization of loops of the yeast mitochondrial ADP/ATP carrier facing the cytosol by site-directed mutagenesis.
Topics: Adenosine Diphosphate; Alanine; Anti-Bacterial Agents; Blotting, Western; Bongkrekic Acid; Cell Division; Cysteine; Cytosol; DNA; DNA Primers; Electrophoresis, Polyacrylamide Gel; Eosine Yellowish-(YS); Fluorescent Dyes; Mitochondria; Mitochondrial ADP, ATP Translocases; Models, Biological; Mutagenesis, Site-Directed; Mutation; Protein Structure, Tertiary; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 2001 |
Identification and characterization of the DNA binding domain of CpG-binding protein.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Base Sequence; Binding Sites; Blotting, Western; CpG Islands; Cysteine; DNA; DNA Methylation; Histidine; Humans; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligonucleotides; Plasmids; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Transcriptional Activation; Zinc | 2001 |
Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activity.
Topics: Alanine; Amino Acid Sequence; Animals; CHO Cells; Chorionic Gonadotropin; COS Cells; Cricetinae; Cysteine; Dimerization; Disulfides; Dose-Response Relationship, Drug; Hormones; Humans; Hydrogen-Ion Concentration; Immunoassay; Luteinizing Hormone; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Rats; Signal Transduction | 2001 |
Role of conservative residue Cys158 in the formation of an active photoprotein complex of obelin.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Apoproteins; Conserved Sequence; Cysteine; Kinetics; Luminescent Measurements; Luminescent Proteins; Recombinant Proteins; Serine | 2001 |
Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Cysteine 184 and histidine 120 of sortase form a thiolate-imidazolium ion pair for catalysis.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Aminoacyltransferases; Bacterial Proteins; Binding Sites; Catalysis; Cell Wall; Cysteine; Cysteine Endopeptidases; Histidine; Hydrolysis; Imidazoles; Ions; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Peptides; Plasmids; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Staphylococcus aureus; Sulfhydryl Compounds; Time Factors; Tryptophan | 2002 |
Adjacent cysteine residues as a redox switch.
Topics: Alanine; Amino Acid Sequence; Catalysis; Cysteine; Disulfides; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Plasmids; Protein Conformation; Ribonuclease, Pancreatic; Sequence Homology, Amino Acid; Serine | 2001 |
[Studies on hereditary deficiency of coagulation factor V].
Topics: Adult; Alanine; Blood Coagulation Disorders, Inherited; Blood Platelets; Cysteine; Factor V; Humans; Male; Plasma; Point Mutation | 2001 |
Differential effect of brefeldin A on the palmitoylation of surfactant protein C proprotein mutants.
Topics: Alanine; Animals; Antioxidants; Brefeldin A; Cell Membrane; Cell Nucleus; CHO Cells; Cricetinae; Cysteine; Immunohistochemistry; Kinetics; Leucine; Masoprocol; Monensin; Mutation; Nocodazole; Palmitic Acid; Palmitic Acids; Peptides; Proline; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Pulmonary Surfactants; Recombinant Proteins; Transfection | 2002 |
Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1.
Topics: Alanine; Alleles; Asparagine; Binding Sites; Calcium; Calcium Channels; Codon; Codon, Nonsense; Cysteine; Fungal Proteins; Hydroxylamine; Immunoblotting; Membrane Glycoproteins; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Threonine; Time Factors; Tryptophan; Two-Hybrid System Techniques | 2002 |
The streptococcal hyaluronan synthases are inhibited by sulfhydryl-modifying reagents, but conserved cysteine residues are not essential for enzyme function.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Carbohydrates; Cysteine; Dose-Response Relationship, Drug; Escherichia coli; Ethylmaleimide; Genetic Variation; Genetic Vectors; Glucuronosyltransferase; Glycosyltransferases; Hyaluronan Synthases; Kinetics; Mass Spectrometry; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Streptococcus; Structure-Activity Relationship; Sulfhydryl Reagents; Transferases; Xenopus Proteins | 2002 |
Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1 from Serratia marcescens.
Topics: Alanine; Amino Acid Sequence; beta-Lactamases; Catalytic Domain; Crystallography, X-Ray; Cysteine; Hydrolysis; Imipenem; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Serratia marcescens | 2002 |
Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Biological Transport; Biotin; Biotinylation; Conserved Sequence; Cysteine; Disulfides; Dithiothreitol; Electrophysiology; Humans; Membrane Proteins; Mercaptoethanol; Molecular Sequence Data; Mutation; Oocytes; Protein Structure, Tertiary; Receptors, Purinergic P2; Receptors, Purinergic P2X; Reducing Agents; Sequence Homology, Amino Acid; Xenopus laevis | 2002 |
Importance of Na,K-ATPase residue alpha 1-Arg544 in the segment Arg544-Asp567 for high-affinity binding of ATP, ADP, or MgATP.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Conserved Sequence; Cysteine; Glutamic Acid; Magnesium; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Saccharomyces cerevisiae; Serine; Sodium-Potassium-Exchanging ATPase; Swine; Thermodynamics | 2002 |
Conformational propensities of protein folding intermediates: distribution of species in the 1S, 2S, and 3S ensembles of the [C40A,C95A] mutant of bovine pancreatic ribonuclease A.
Topics: Alanine; Animals; Cattle; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Endopeptidases; Hydrolysis; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Ribonuclease, Pancreatic | 2002 |
A site-directed mutagenesis analysis of tNOX functional domains.
Topics: Alanine; Binding Sites; Capsaicin; Cysteine; Enzyme Inhibitors; Escherichia coli; Mutagenesis, Site-Directed; NAD; NADH, NADPH Oxidoreductases; Recombinant Proteins; Time Factors | 2002 |
NMR structural study of two-disulfide variant of hen lysozyme: 2SS[6-127, 30-115]--a disulfide intermediate with a partly unfolded structure.
Topics: Alanine; Amino Acid Substitution; Animals; Chickens; Cysteine; Disulfides; Genetic Variation; Methionine; Muramidase; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Folding; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Protons; Recombinant Proteins | 2002 |
Modulation of cyanoalanine synthase and O-acetylserine (thiol) lyases A and B activity by beta-substituted alanyl and anion inhibitors.
Topics: Alanine; Allosteric Regulation; Allosteric Site; Anions; Carbon-Oxygen Lyases; Cysteine; Cysteine Synthase; Dimerization; Homocysteine; Hydrogen Bonding; Intracellular Membranes; Isoenzymes; Kinetics; Lyases; Mitochondria; Models, Biological; Multienzyme Complexes; Potassium Cyanide; Saccharomyces cerevisiae Proteins; Serine; Spinacia oleracea | 2002 |
Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Estradiol; Lysine; Macromolecular Substances; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phosphoadenosine Phosphosulfate; Protein Binding; Protein Conformation; Serine; Sulfates; Sulfotransferases | 2002 |
Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor.
Topics: Alanine; Amino Acid Substitution; Animals; Catalysis; COS Cells; Cysteine; Dithiothreitol; Genetic Vectors; Humans; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Kinetics; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Selenocysteine; Thyroxine; Triiodothyronine | 2002 |
Recombinant lysine:N(6)-hydroxylase: effect of cysteine-->alanine replacements on structural integrity and catalytic competence.
Topics: Alanine; Calorimetry, Differential Scanning; Cysteine; Dithionitrobenzoic Acid; Enzyme Stability; Flavin-Adenine Dinucleotide; Hot Temperature; Iopanoic Acid; Kinetics; Mixed Function Oxygenases; Models, Chemical; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Recombinant Proteins | 2002 |
Zn(2+) binding properties of single-point mutants of the C-terminal zinc finger of the HIV-1 nucleocapsid protein: evidence of a critical role of cysteine 49 in Zn(2+) dissociation.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Capsid; Capsid Proteins; Cobalt; Cysteine; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; Histidine; HIV-1; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Point Mutation; Protein Binding; Serine; Spectrophotometry; Viral Proteins; Zinc; Zinc Fingers | 2002 |
Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function.
Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Base Sequence; Cell Line; Circular Dichroism; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutathione Transferase; Insecta; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Point Mutation; Potassium; Proline; Protein Folding; Recombinant Proteins; Sequence Homology, Amino Acid; Spider Venoms; Tyrosine; Ultraviolet Rays | 2002 |
Iron-sulfur cluster biosynthesis: characterization of Schizosaccharomyces pombe Isa1.
Topics: Alanine; Amino Acid Sequence; Cloning, Molecular; Cross-Linking Reagents; Cysteine; DNA-Binding Proteins; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferredoxins; Iron-Sulfur Proteins; Molecular Sequence Data; Mutation; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Sequence Homology, Amino Acid; Spectroscopy, Mossbauer; Transcription Factors | 2002 |
The activity of leukocyte NADPH oxidase: regulation by p47PHOX cysteine and serine residues.
Topics: Alanine; Cell-Free System; Cysteine; Cytosol; Gene Expression Regulation, Enzymologic; Humans; Leukocytes; Lymphocytes; Mutation; NADPH Oxidases; Oxidation-Reduction; Phosphoproteins; Phosphorylation; Serine | 2002 |
Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: implications for the mechanism of iron-sulfur cluster assembly.
Topics: Alanine; Bacterial Proteins; Binding Sites; Carbon-Sulfur Lyases; Cysteine; Disulfides; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Proteins; Iron; Iron-Sulfur Proteins; Lyases; Models, Chemical; Protein Binding; Sulfur; Time Factors | 2002 |
Repression of photosynthesis gene expression by formation of a disulfide bond in CrtJ.
Topics: Aerobiosis; Alanine; Bacterial Proteins; Cysteine; Disulfides; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Mutagenesis; Oxidoreductases; Oxygen; Photosynthesis; Promoter Regions, Genetic; Repressor Proteins; Rhodobacter capsulatus; Transcription Factors | 2002 |
Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport of lipophilic cationic compounds.
Topics: Alanine; Amino Acid Substitution; Bacterial Proteins; Benzimidazoles; Binding Sites; Biological Transport, Active; Cell Membrane; Cysteine; Drug Resistance, Multiple; Ethidium; Fluoresceins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary | 2002 |
Changing the lactose permease of Escherichia coli into a galactose-specific symporter.
Topics: Alanine; Calcium-Binding Proteins; Cysteine; Disaccharides; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Galactose; Lactose; Membrane Transport Proteins; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Periplasmic Binding Proteins; Substrate Specificity; Symporters | 2002 |
Characterization of the first cytoplasmic loop of subunit a of the Escherichia coli ATP synthase by surface labeling, cross-linking, and mutagenesis.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Bacterial Proton-Translocating ATPases; Cross-Linking Reagents; Cysteine; Cytoplasm; Escherichia coli; Glutamine; Immunoblotting; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Time Factors | 2002 |
Atypical muscle pathology and a survey of cis-mutations in deaf patients harboring a 1555 A-to-G point mutation in the mitochondrial ribosomal RNA gene.
Topics: Adult; Alanine; Anti-Bacterial Agents; Audiology; Cysteine; Cytochrome b Group; Deafness; DNA, Mitochondrial; Female; Glycine; Hearing; Humans; Male; Middle Aged; Muscle, Skeletal; Mutation; Pedigree; Point Mutation; RNA; RNA, Mitochondrial; RNA, Ribosomal; Streptomycin; Threonine | 2002 |
Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; COS Cells; Cross-Linking Reagents; Cysteine; Disulfides; Ethyl Methanesulfonate; Hydrolysis; Ligands; Molecular Sequence Data; Muscarinic Agonists; Muscarinic Antagonists; Mutagenesis, Site-Directed; N-Methylscopolamine; Peptide Fragments; Peptide Mapping; Phosphatidylinositols; Protein Structure, Tertiary; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Sulfhydryl Compounds; Transfection; Tritium | 2002 |
A 13C-NMR study of the inhibition of papain by a dipeptide-glyoxal inhibitor.
Topics: Alanine; Catalysis; Cysteine; Dipeptides; Glyoxal; Magnetic Resonance Spectroscopy; Models, Chemical; Papain; Phenylalanine; Sulfhydryl Compounds | 2002 |
Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C.
Topics: Alanine; Binding Sites; Catalysis; Chromatography, Gel; Cysteine; Disulfides; Dithiothreitol; DNA, Superhelical; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutamate-Ammonia Ligase; Iron; Kinetics; Models, Biological; Mutagenesis, Site-Directed; Mutation; Mycobacterium tuberculosis; Oxygen; Peroxidases; Peroxiredoxins; Plasmids; Sulfhydryl Compounds | 2002 |
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.
Topics: Alanine; Amino Acid Substitution; Animals; Cell Line; Cysteine; DNA; DNA Nucleotidyltransferases; DNA-Binding Proteins; Gene Rearrangement, B-Lymphocyte; Genes, RAG-1; Glutamic Acid; Homeodomain Proteins; Humans; Macromolecular Substances; Mice; Mutagenesis, Site-Directed; Nuclear Proteins; Nucleic Acid Conformation; Phenotype; Protein Interaction Mapping; Recombinant Fusion Proteins; Recombination, Genetic; Regulatory Sequences, Nucleic Acid; Serine; Substrate Specificity; VDJ Recombinases | 2002 |
Regulation of cAMP-dependent protein kinase activity by glutathionylation.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Biotinylation; Conserved Sequence; Cyclic AMP-Dependent Protein Kinases; Cysteine; Diamide; Glutathione; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Processing, Post-Translational; Protein Subunits; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sulfhydryl Compounds | 2002 |
Association of human papillomavirus type 58 variant with the risk of cervical cancer.
Topics: Adult; Alanine; Base Sequence; Cysteine; Female; Genetic Variation; Glycine; Hong Kong; Humans; Middle Aged; Molecular Sequence Data; Neoplasm Invasiveness; Odds Ratio; Papillomaviridae; Papillomavirus Infections; Point Mutation; Prevalence; Risk; Severity of Illness Index; Threonine; Tumor Virus Infections; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2002 |
Locking the hydrophobic loop 262-274 to G-actin surface by a disulfide bridge prevents filament formation.
Topics: Actin Cytoskeleton; Actins; Alanine; Cross-Linking Reagents; Cysteine; Disulfides; Dithiothreitol; Hydrophobic and Hydrophilic Interactions; Leucine; Magnesium Chloride; Mutagenesis, Site-Directed; Oxidation-Reduction; Peptide Fragments; Phalloidine; Polymers; Protein Engineering; Protein Structure, Tertiary; Saccharomyces cerevisiae Proteins | 2002 |
An intramolecular disulfide bridge as a catalytic switch for serotonin N-acetyltransferase.
Topics: Alanine; Amino Acid Sequence; Animals; Arylamine N-Acetyltransferase; Catalysis; COS Cells; Cysteine; Disulfides; Dose-Response Relationship, Drug; Hydrogen Peroxide; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxidative Stress; Peptides; Protein Binding; Time Factors | 2002 |
Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cell Separation; Cells, Cultured; Colchicine; Cysteine; DNA Mutational Analysis; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Glycosylation; Humans; Kinetics; Leukotriene C4; Microscopy, Confocal; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Structure-Activity Relationship; Time Factors; Transfection; Trypsin; Vincristine | 2002 |
Isolation and characterization of modified species of a mutated (Cys125 -Ala) recombinant human interleukin-2.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cysteine; Electrophoresis, Polyacrylamide Gel; Humans; Interleukin-2; Molecular Sequence Data; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization | 2002 |
Stabilization of the R allosteric structure of Escherichia coli aspartate transcarbamoylase by disulfide bond formation.
Topics: Adenosine Triphosphate; Alanine; Allosteric Site; Aspartate Carbamoyltransferase; Aspartic Acid; Catalysis; Catalytic Domain; Cross-Linking Reagents; Cysteine; Cytidine Triphosphate; Disulfides; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Kinetics; Models, Molecular; Mutation; Protein Binding; Protein Structure, Quaternary; Scattering, Radiation; X-Rays | 2002 |
The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Asialoglycoprotein Receptor; Cell Membrane; COS Cells; Cysteine; Cytoplasm; DNA, Complementary; Humans; Molecular Sequence Data; Mutation; Palmitic Acid; Palmitic Acids; Plasmids; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Transfection | 2002 |
Posttranslational modification of serine to formylglycine in bacterial sulfatases. Recognition of the modification motif by the iron-sulfur protein AtsB.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Arylsulfatases; beta-Galactosidase; Blotting, Western; Cysteine; Cytosol; Dose-Response Relationship, Drug; Escherichia coli; Glutathione Transferase; Glycine; Iron-Sulfur Proteins; Klebsiella pneumoniae; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Protein Binding; Protein Processing, Post-Translational; Protein Sorting Signals; Serine; Subcellular Fractions; Sulfatases; Two-Hybrid System Techniques | 2003 |
Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A1 and rat A3 adenosine receptors: consequences for agonist-stimulated translocation of arrestin3.
Topics: Alanine; Animals; Arrestins; beta-Adrenergic Receptor Kinases; Cell Line; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cysteine; Endosomes; Green Fluorescent Proteins; Humans; Kinetics; Luminescent Proteins; Mutagenesis, Site-Directed; Palmitic Acid; Phosphorylation; Protein Structure, Tertiary; Protein Transport; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Recombinant Fusion Proteins; Transfection | 2002 |
[Association of the renin-angiotensin system gene polymorphism with nephropathy in type II diabetes].
Topics: Adult; Alanine; Alleles; Angiotensinogen; Case-Control Studies; Cysteine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Female; Genotype; Humans; Male; Methionine; Middle Aged; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin-Angiotensin System; Threonine | 2002 |
Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells.
Topics: Alanine; Amino Acid Transport Systems; Amino Acids, Cyclic; Animals; beta-Alanine; Biological Transport; Calcium; Cysteine; Dose-Response Relationship, Drug; Leucine; Nitric Oxide Donors; PC12 Cells; Phenylalanine; Rats; RNA, Messenger; S-Nitrosothiols; Stereoisomerism; Tritium | 2003 |
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
Topics: Alanine; Algorithms; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Blotting, Western; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Catalysis; Cysteine; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Kinetics; Malonyl Coenzyme A; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Point Mutation; Protein Binding; Protein Isoforms; Rats; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Threonine | 2003 |
Structural and thermodynamic studies on a salt-bridge triad in the NADP-binding domain of glutamate dehydrogenase from Thermotoga maritima: cooperativity and electrostatic contribution to stability.
Topics: Alanine; Arginine; Binding Sites; Crystallography, X-Ray; Cysteine; Enzyme Stability; Glutamate Dehydrogenase; Glutamic Acid; Guanidine; Lysine; Mutagenesis, Site-Directed; NADP; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Salts; Serine; Static Electricity; Structure-Activity Relationship; Thermodynamics; Thermotoga maritima; Urea | 2002 |
Dramatic stabilization of the native state of human carbonic anhydrase II by an engineered disulfide bond.
Topics: Alanine; Amino Acid Substitution; Carbonic Anhydrase II; Circular Dichroism; Cysteine; Disulfides; Enzyme Activation; Enzyme Stability; Genetic Variation; Guanidine; Humans; Leucine; Mutagenesis, Site-Directed; Neisseria gonorrhoeae; Protein Denaturation; Protein Folding | 2002 |
Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2.
Topics: Alanine; Amino Acid Substitution; Animals; Brain; Cell Membrane; Cysteine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Secondary; Rats; Recombinant Proteins; Sodium-Calcium Exchanger; Transfection | 2002 |
Understanding the dynamics of Spinocerebellar Ataxia 8 (SCA8) locus through a comparative genetic approach in humans and apes.
Topics: Alanine; Alleles; Animals; Cysteine; Genetic Variation; Glycine; Gorilla gorilla; Humans; Nerve Tissue Proteins; Pan troglodytes; Polymerase Chain Reaction; Pongo pygmaeus; Risk Factors; RNA, Long Noncoding; RNA, Untranslated; Species Specificity; Spinocerebellar Degenerations; Threonine; Trinucleotide Repeat Expansion | 2003 |
Genetic variation in cyclooxygenase 1: effects on response to aspirin.
Topics: Adult; Alanine; Aspirin; Blood Platelets; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cysteine; Dinoprost; DNA, Complementary; Ethanol; Female; Glycine; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Reference Values; Sequence Analysis, DNA; Sex Characteristics; Threonine; Thromboxane B2 | 2003 |
CAG mutation effect on rate of progression in Huntington's disease.
Topics: Age of Onset; Alanine; Cysteine; Disease Progression; DNA Mutational Analysis; Female; Follow-Up Studies; Glycine; Humans; Huntington Disease; Male; Mutation; Phenotype; Trinucleotide Repeat Expansion | 2002 |
Mutational analysis of roles for extracellular cysteine residues in the assembly and function of human alpha 7-nicotinic acetylcholine receptors.
Topics: Alanine; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Cell Line; Cell Membrane; Conserved Sequence; Cysteine; DNA Mutational Analysis; Extracellular Space; Humans; Iodine Radioisotopes; Kinetics; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Binding; Protein Subunits; Receptors, Nicotinic; Transfection | 2003 |
Identification of a functionally important conformation-sensitive region of the secretory Na+-K+-2Cl- cotransporter (NKCC1).
Topics: Alanine; Amino Acid Sequence; Animals; Biological Transport; Cell Line; Cysteine; Ethyl Methanesulfonate; Extracellular Space; Humans; Kidney; Mercury; Mesylates; Molecular Sequence Data; Mutagenesis; Protein Conformation; Rats; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Sulfhydryl Reagents | 2003 |
The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin.
Topics: Alanine; Azurin; Calorimetry, Differential Scanning; Copper; Cysteine; Kinetics; Protein Conformation; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Temperature; Thermodynamics; Zinc | 2003 |
Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Alanine; Animals; Aspartic Acid; Cell Line; COS Cells; Cysteine; ErbB Receptors; Helminth Proteins; Humans; Immunoblotting; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Serine; Signal Transduction; src Homology Domains; Transfection | 2003 |
Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications.
Topics: Alanine; Amino Acid Sequence; Carbon-Carbon Lyases; Carboxylic Acids; Catalysis; Chromatography, High Pressure Liquid; Cloning, Molecular; Crotonates; Cyclopropanes; Cysteine; Dithionitrobenzoic Acid; Glycine; Kinetics; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Pseudomonas; Recombinant Proteins; Serine; Titrimetry | 2003 |
Influence of interleukin-12 receptor beta1 polymorphisms on tuberculosis.
Topics: Adult; Aged; Alanine; Asian People; Blotting, Western; Case-Control Studies; Cysteine; Female; Genetic Predisposition to Disease; Genotype; Glycine; Haplotypes; Humans; Interferon-gamma; Japan; Killer Cells, Natural; Male; Middle Aged; Mutation, Missense; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, Interleukin; Receptors, Interleukin-12; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Threonine; Tuberculosis | 2003 |
Progressive skeletal myopathy, a phenotypic variant of desmin myopathy associated with desmin mutations.
Topics: Alanine; Animals; Carcinoma; Cell Line; Cysteine; Desmin; DNA Mutational Analysis; Female; Fluorescent Antibody Technique; Glycine; Humans; Male; Methionine; Mice; Molecular Sequence Data; Muscular Diseases; Myoblasts; Pedigree; Phenotype; Point Mutation; Transfection | 2003 |
Partial rescue of functional interactions of a nonpalmitoylated mutant of the G-protein G alpha s by fusion to the beta-adrenergic receptor.
Topics: Adenylyl Cyclases; Alanine; Animals; Cell Membrane; Cysteine; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gs; Humans; Hydroxylamine; Intracellular Fluid; Mice; Mutagenesis, Site-Directed; Palmitic Acid; Protein Binding; Protein Subunits; Protein Transport; Rats; Receptors, Adrenergic, beta-2; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured | 2003 |
Substrate specificity of mutants of the hydroxynitrile lyase from Manihot esculenta.
Topics: Alanine; Aldehyde-Lyases; Chromatography, Gas; Cysteine; Leucine; Manihot; Mutation; Nitriles; Tyrosine | 2003 |
Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations.
Topics: Alanine; Asia; Case-Control Studies; Chi-Square Distribution; Cysteine; Ethnicity; Exons; Gene Frequency; Genotype; Glycine; Heroin Dependence; Humans; Linkage Disequilibrium; Mutation; Polymorphism, Genetic; Receptors, Opioid, mu; Threonine | 2003 |
Enantioselective synthesis of alpha-methyl-D-cysteine and lanthionine building blocks via alpha-methyl-D-serine-beta-lactone.
Topics: Alanine; Cysteine; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Serine; Sulfides | 2003 |
Characterization of an Escherichia coli mutant MutY with a cysteine to alanine mutation at the iron-sulfur cluster domain.
Topics: Alanine; Bacterial Proteins; Cysteine; DNA Glycosylases; DNA Primers; DNA Repair; DNA, Bacterial; Enzyme Activation; Enzyme Stability; Escherichia coli; Iron-Sulfur Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; N-Glycosyl Hydrolases; Polymerase Chain Reaction; Protein Binding; Protein Denaturation; Recombinant Fusion Proteins | 2003 |
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family.
Topics: Adolescent; Adult; Alanine; Child; Cysteine; Female; Genetic Linkage; Glycine; Hemiplegia; Humans; Lod Score; Male; Microsatellite Repeats; Middle Aged; Migraine Disorders; Mutation, Missense; Phenotype; Polymorphism, Single-Stranded Conformational; Spinocerebellar Ataxias | 2003 |
ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore.
Topics: Alanine; Apolipoprotein A-I; Asian People; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Cysteine; Genotype; Glycine; Haplotypes; Humans; India; Isoleucine; Linkage Disequilibrium; Lipids; Malaysia; Male; Methionine; Polymorphism, Genetic; Sequence Analysis, DNA; Singapore; Threonine; Triglycerides; Valine; White People | 2003 |
Apolipoprotein E, angiotensin-converting enzyme and alpha-1-antichymotrypsin genotypes are not associated with post-stroke dementia.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Alleles; alpha 1-Antitrypsin; Apolipoproteins E; Cysteine; Dementia; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation; Neuropsychological Tests; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Promoter Regions, Genetic; Stroke; Threonine | 2003 |
Natural disulfide bond-disrupted mutants of AVR4 of the tomato pathogen Cladosporium fulvum are sensitive to proteolysis, circumvent Cf-4-mediated resistance, but retain their chitin binding ability.
Topics: Alanine; Amino Acids; Blood Proteins; Carrier Proteins; Chitin; Chromatography, High Pressure Liquid; Cladosporium; Cysteine; Disulfides; Fungal Proteins; Genotype; Magnetic Resonance Spectroscopy; Models, Molecular; Mutation; Necrosis; Peptides; Phenotype; Polysaccharides; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Solanum lycopersicum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Transcription, Genetic; Tyrosine | 2003 |
Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference.
Topics: Alanine; Amino Acid Substitution; Animals; Catalytic Domain; COS Cells; Cysteine; Enzyme Activation; Humans; In Vitro Techniques; Iodide Peroxidase; Mutagenesis, Site-Directed; Selenocysteine; Substrate Specificity; Thyroxine; Triiodothyronine | 2003 |
MG2 and lactoferrin form a heterotypic complex in salivary secretions.
Topics: Adult; Alanine; Cysteine; Humans; Immunoglobulin A, Secretory; Lactoferrin; Leucine; Mucins; Oligopeptides; Oxidants; Periodic Acid; Protein Binding; Protein Interaction Mapping; Salivary Proteins and Peptides; Sequence Analysis, Protein; Species Specificity | 2003 |
Protein and gene analyses of dysferlinopathy in a large group of Japanese muscular dystrophy patients.
Topics: Age of Onset; Alanine; Blotting, Western; Calpain; Cysteine; Cytoskeletal Proteins; DNA Mutational Analysis; Dysferlin; Dystroglycans; Dystrophin; Glycine; Humans; Immunohistochemistry; Japan; Membrane Glycoproteins; Membrane Proteins; Muscle Proteins; Muscle, Skeletal; Muscular Dystrophies; Mutation; Neuromuscular Diseases; Sarcoglycans; Sequence Analysis, Protein; Tyrosine | 2003 |
Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite.
Topics: Alanine; Amino Acids; Animals; Arginine; Binding Sites; Cysteine; Eukaryotic Initiation Factor-4G; Glutathione Transferase; Glycine; Models, Genetic; Models, Molecular; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Structure, Tertiary; Rabbits; Recombinant Fusion Proteins; Reticulocytes; Rhinovirus; Rosaniline Dyes; Time Factors; Tyrosine | 2003 |
Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads.
Topics: Adolescent; Adult; Alanine; Case-Control Studies; Cleft Lip; Cleft Palate; Cysteine; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Haplotypes; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Norway; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Registries; Risk Factors; Threonine | 2003 |
Mutational analysis of the human FATE gene in 144 infertile men.
Topics: Adult; Alanine; Amino Acid Sequence; Animals; Arginine; Cysteine; DNA Mutational Analysis; DNA Primers; DNA-Binding Proteins; Exons; Humans; Infertility, Male; Introns; Karyotyping; Male; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Polymorphism, Genetic; Serine; Threonine; Transcription Factors; X Chromosome | 2003 |
Protein stability and plasticity of the hydrophobic cavity in wheat ns-LTP.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Antigens, Plant; Carrier Proteins; Computer Simulation; Cysteine; Disulfides; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Plant Proteins; Point Mutation; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Temperature; Triticum; Water | 2003 |
Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.
Topics: 14-3-3 Proteins; Adaptor Proteins, Signal Transducing; Alanine; Alkaline Phosphatase; Amino Acid Motifs; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromaffin Cells; Cross-Linking Reagents; Cysteine; Dose-Response Relationship, Drug; Exocytosis; Glutathione Transferase; GTP-Binding Proteins; Humans; Models, Genetic; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; rab GTP-Binding Proteins; rab3 GTP-Binding Proteins; Rabphilin-3A; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Temperature; Transfection; Two-Hybrid System Techniques; Tyrosine 3-Monooxygenase; Vesicular Transport Proteins; Zinc Fingers | 2003 |
Biogenesis of Fe-S cluster by the bacterial Suf system: SufS and SufE form a new type of cysteine desulfurase.
Topics: Alanine; Bacterial Proteins; Carbon-Sulfur Lyases; Chromatography; Chromatography, Gel; Cysteine; Cytosol; Dickeya chrysanthemi; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunoblotting; Iron-Sulfur Proteins; Kinetics; Lyases; Models, Biological; Models, Chemical; Mutagenesis, Site-Directed; Plasmids; Protein Binding; Selenocysteine; Subcellular Fractions; Time Factors; Two-Hybrid System Techniques | 2003 |
Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase.
Topics: Alanine; Cell Line, Tumor; Cysteine; Electrophoretic Mobility Shift Assay; Humans; Luciferases; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Biosynthesis; RNA-Binding Proteins; RNA, Messenger; Thymidylate Synthase; Transfection | 2003 |
The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.
Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Biotin; Biotinylation; Carrier Proteins; Cell Membrane; Cricetinae; Cysteine; Cytosol; Folic Acid; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reduced Folate Carrier Protein; RNA; Streptolysins | 2003 |
2-D array formation of genetically engineered viral cages on au surfaces and imaging by atomic force microscopy.
Topics: Alanine; Amino Acid Substitution; Bromovirus; Capsid Proteins; Cysteine; Genetic Engineering; Gold; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Protein Conformation; Virion | 2003 |
[Enzymatic desulfination and decarboxylation of the l-cysteine sulfinic acid; its quantitative transformation into alanine & hypotaurine].
Topics: Alanine; Biochemical Phenomena; Cysteine; Decarboxylation; Hydro-Lyases; Lyases; Sulfinic Acids; Taurine | 1952 |
[Desulfination and decarboxylation of the l-cysteine sulfinic acid in the living animal].
Topics: Alanine; Animals; Biochemical Phenomena; Cysteine; Decarboxylation; Hydro-Lyases; Life; Lyases; Sulfinic Acids | 1952 |
Enzymic decarboxylation of cysteic and cysteine sulphinic acids.
Topics: Alanine; Cysteine; Decarboxylation; Liver Extracts | 1954 |
[Microbiological evaluation of the alliin-alliinase enzymesubstrate system].
Topics: Alanine; Anti-Bacterial Agents; Antibiotics, Antitubercular; Carbon-Sulfur Lyases; Cysteine; Dermatologic Agents; Enzymes | 1954 |
[Formation of thiosulfate from alaninethiosulfonic acid and from cysteinesulfonate].
Topics: Alanine; Cysteine; Thiosulfates | 1960 |
Amino acids, amino sugars and sugars present in the cell wall of some strains of Streptococcus pyogenes.
Topics: Alanine; Amino Acids; Amino Sugars; Arginine; Aspartic Acid; Cell Wall; Cysteine; Glucosamine; Glutamates; Glycine; Hexosamines; Isoleucine; Leucine; Lysine; Serine; Streptococcus pyogenes; Threonine; Valine | 1962 |
[Decomposition of cystine, cysteine, cystine-dihydantoin, lanthionine and lanthionine-dihydantoin in aqueous solutions].
Topics: Alanine; Amino Acids; Cysteine; Cystine; Hydantoins; Sulfides | 1962 |
[Study of thge degradation of L-cysteine by a apurified enzyme isolated isolatted form rat liver("soluble" cystein desulfurase or cystathinase)].
Topics: Alanine; Animals; Cysteine; Liver; Lyases; Pyruvates; Rats; Sulfides | 1963 |
[RESEARCH ON THE NUTRITION OF ERWINIA CAROTOVORA].
Topics: Alanine; Aminobutyrates; Ammonium Compounds; Arginine; Asparagine; Aspartic Acid; Boron; Calcium; Cobalt; Copper; Creatine; Creatinine; Culture; Culture Media; Cysteine; Cystine; Erwinia; Glutamates; Glycine; Iron; Lysine; Magnesium; Manganese; Methionine; Minerals; Molybdenum; Pectobacterium carotovorum; Proteins; Quaternary Ammonium Compounds; Tryptophan; Tyrosine; Zinc | 1963 |
ENVIRONMENTAL CONTROL OF THE COURSE OF DEVELOPMENT IN DICTYOSTELIUM DISCOIDEUM.
Topics: Alanine; Calcium; Calcium, Dietary; Carbohydrate Metabolism; Chlorides; Citrates; Culture Media; Cysteine; Dictyostelium; Fungi; Glucose; Glycine; Histidine; Hydrogen-Ion Concentration; Magnesium; Potassium; Proteins; Sodium; Succinates | 1963 |
STUDIES ON COLLETOTRICHUM CAPSICI III. THE EFFECT OF INITIAL PH ON THE GROWTH AND AMINO ACID COMPOSITION.
Topics: Alanine; Amino Acids; Aminobutyrates; Arginine; Aspartic Acid; Chromatography; Colletotrichum; Cysteine; Fungi; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Phenylalanine; Research; Serine; Tyrosine | 1963 |
[SOME EXPERIMENTAL DATA ON THE ROLE OF SOLUBLE RNA IN PROTEIN SYNTHESIS].
Topics: Alanine; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Leucine; Liver; Nucleoproteins; Protein Biosynthesis; Proteins; Rats; Research; RNA; RNA, Bacterial; Sulfonic Acids; Yeasts | 1963 |
[SPECIFICITY OF ACTIVATION ENZYMES WITH RESPECT TO RIBONUCLEIC ACIDS ESTERIFIED BY AMINO ACIDS].
Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Ligases; Methionine; Nucleoproteins; Poultry; Proteins; Research; RNA; RNA, Bacterial; Serine; Sulfur Isotopes; Tyrosine | 1963 |
[STUDY OF THE PURIFICATION AND PROPERTIES OF 6-PHOSPHOGLUCONATE DEHYDROGENASE (6 PGD) EXTRACTED FROM BACILLUS SUBTILIS].
Topics: Alanine; Bacillus subtilis; Chromatography; Cysteine; Enzyme Inhibitors; Gluconates; Glycine; Glycosides; Ion Exchange Resins; NADP; Oxidoreductases; Peptides; Phosphogluconate Dehydrogenase; Prostaglandins D; Research; Sulfhydryl Compounds; Valine | 1963 |
FURTHER STUDIES OF RADIATION EFFECTS ON THE PROTEINS AND THEIR CONSTITUENTS.
Topics: Alanine; Amino Acids; Animals; Caseins; Cattle; Chemistry Techniques, Analytical; Chymotrypsin; Collagen; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Gelatin; Glycine; Histones; Muramidase; Ovalbumin; Pepsin A; Proteins; Radiation Effects; Ribonucleases; Serum Albumin; Serum Albumin, Bovine; Temperature; Zein | 1964 |
A SIMPLE PREPARATION METHOD FOR DIPHOSPHOMIDAZOLE.
Topics: Alanine; Amides; Calcium Phosphates; Chlorides; Chromatography; Cysteine; Cystine; Glycine; Histidine; Imidazoles; Ion Exchange Resins; Methionine; Phosphates; Phosphorus; Research; Serine; Tryptophan; Tyrosine | 1964 |
NUTRITIONAL FACTORS RELATING TO GROWTH AND OXYTETRACYCLINE FORMATION BY STREPTOMYCES RIMOSUS.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Culture Media; Cysteine; Cystine; Glutamine; Glycine; Histidine; Isoleucine; Lysine; Metabolism; Methionine; Oxytetracycline; Research; Serine; Streptomyces; Streptomyces rimosus | 1964 |
INOTROPIC ACTIVITY OF A SERIES OF AMINO ACIDS.
Topics: Adrenal Glands; Alanine; Amino Acids; Blood Pressure; Cysteine; Dogs; Glycine; Heart; Leucine; Methionine; Pharmacology; Research; Sensory Receptor Cells; Serine; Threonine | 1964 |
THE DEVELOPMENTAL SIGNIFICANCE OF ALANINE DEHYDROGENASE IN BACILLUS SUBTILIS.
Topics: Alanine; Alanine Dehydrogenase; Alanine Transaminase; Amino Acid Oxidoreductases; Amino Acids; Aminobutyrates; Ammonia; Aspartate Aminotransferases; Bacillus subtilis; Cysteine; Isoleucine; Leucine; Lyases; Methionine; Mutation; Research; Serine; Spectrophotometry; Spores; Spores, Bacterial; Valine | 1964 |
RECOMBINATION BETWEEN NOCARDIA ERYTHROPOLIS AND NOCARDIA CANICRURIA.
Topics: Adenine; Alanine; Anti-Bacterial Agents; Arginine; Cysteine; Cystine; Drug Resistance; Drug Resistance, Microbial; Glycine; Guanine; Histidine; Hypoxanthines; Isoleucine; Leucine; Lysine; Metabolism; Methionine; Mutation; Nocardia; Recombination, Genetic; Research; Streptomycin; Valine; Xanthines | 1964 |
AMINO ACIDS AS PROTECTIVE COMPOUNDS IN ULTRAVIOLET-IRRADIATED HANSENULA WINGEI.
Topics: Alanine; Amino Acids; Arginine; Cysteine; Cystine; Ethionine; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Pichia; Proline; Radiation-Protective Agents; Research; Serine; Threonine; Tryptophan; Tyrosine; Ultraviolet Rays; Valine; Yeasts | 1964 |
SELENOAMINO ACIDS AS RADIATION PROTECTORS IN VITRO.
Topics: Alanine; Alcohol Oxidoreductases; Amino Acids; Arginine; Cysteine; Cystine; Histidine; In Vitro Techniques; Leucine; Methionine; Phenylalanine; Radiation-Protective Agents; Research; Ribonucleases; Selenium; Serine | 1964 |
A PYRIDOXAL-BETA-CYANOALANINE RELATION IN THE RAT.
Topics: Alanine; Amino Acids; Anticonvulsants; Chromatography; Cysteine; Enzyme Inhibitors; Lathyrism; Peptides; Pharmacology; Pyridoxal; Pyridoxine; Radiometry; Rats; Research; Seeds; Toxicology; Urine | 1964 |
ENZYMATIC DESULFINATION OF CYSTEINE SULFINIC ACID.
Topics: Alanine; Alcaligenes; Aspartic Acid; Biochemical Phenomena; Biochemistry; Carboxy-Lyases; Cysteine; Keto Acids; Ketoglutaric Acids; Pyridoxal Phosphate; Research; Sulfites | 1964 |
PENETRATING OF BRAIN AND BRAIN TUMOR. V. COPPER-64 CHELATES.
Topics: Alanine; Animals; Biological Transport; Blood; Brain; Brain Neoplasms; Chelating Agents; Copper; Cysteine; Isonicotinic Acids; Metabolism; Mice; Muscles; Pentetic Acid; Radioisotopes; Radionuclide Imaging; Research | 1964 |
METABOLIC PRODUCTS IN PIGEON TISSUES AFTER FEEDING GLUCOSE.
Topics: Alanine; Animals; Arginine; Aspartic Acid; Birds; Carbohydrate Metabolism; Carbon Isotopes; Columbidae; Cysteine; Dietary Carbohydrates; Fructose; Glucose; Glutamates; Lactates; Muscles; Myocardium; Research | 1964 |
THE MAJOR ALKALINE PROTEINASE OF ASPERGILLUS ORYZAE, ASPERGILLOPEPTIDASE B. II. PARTIAL SPECIFIC VOLUME, MOLECULAR WEIGHT, AND AMINO ACID COMPOSITION.
Topics: Alanine; Amides; Amino Acids; Aspergillus; Aspergillus oryzae; Bacterial Proteins; Buffers; Chemical Phenomena; Chemistry, Physical; Cysteine; Cystine; Densitometry; Endopeptidases; Glycine; Molecular Weight; Nitrogen; Peptide Hydrolases; Research; Serine; Serine Endopeptidases; Tryptophan | 1964 |
ENZYMATIC PROPERTIES OF ALANINE DEHYDROGENASE OF BACILLUS SUBTILIS.
Topics: Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Amino Acids; Aminobutyrates; Bacillus subtilis; Benzoates; Caproates; Chemical Phenomena; Chemistry; Chloromercuribenzoates; Cysteine; Isoleucine; Ketoglutaric Acids; Metals; NAD; Oxalates; Pyruvates; Research; Serine; Valine | 1965 |
FORMATION OF A D-ALANYL PEPTIDE IN EXTRACTS OF LACTOBACILLUS PLANTARUM.
Topics: Adenosine Triphosphate; Alanine; Chromatography; Cysteine; Electrophoresis; Lactobacillus; Lactobacillus plantarum; Peptides; Research | 1965 |
Nitrogenous compounds in germination and postgerminative development of Bacillus megaterium spores.
Topics: Alanine; Arginine; Asparagine; Bacillus; Bacillus megaterium; Culture Media; Cysteine; Hot Temperature; Leucine; Nitrates; Nitrogen; Proline; Spores, Bacterial; Valine | 1962 |
L-Alanine dehydrogenase: a mechanism controlling the specificity of amino acid-induced germination of Bacillus cereus spores.
Topics: Alanine; Alanine Dehydrogenase; Amino Acids; Bacillus; Bacillus cereus; Cysteine; Oxidoreductases; Spores, Bacterial | 1961 |
Utilization of sulfur compounds by Streptococcus bovis.
Topics: Alanine; Amino Acids; Arginine; Cysteine; Methionine; Nitrogen; Streptococcus; Streptococcus bovis; Sulfates; Sulfides; Sulfites; Sulfur; Thiosulfates | 1961 |
Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia.
Topics: Alanine; Alleles; Chi-Square Distribution; Cysteine; DNA Mutational Analysis; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Lymphocytes; Methylenetetrahydrofolate Reductase (NADPH2); Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Schizophrenia; Threonine | 2003 |
Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits.
Topics: Adult; Alanine; Alleles; Cysteine; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Personality; Polymerase Chain Reaction; Polymorphism, Genetic; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Surveys and Questionnaires; Threonine; Tryptophan Hydroxylase | 2003 |
Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients.
Topics: Adolescent; Adult; Aged; Alanine; Case-Control Studies; Cognition; Cysteine; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Polymerase Chain Reaction; Polymorphism, Genetic; Psychiatric Status Rating Scales; Receptor, Muscarinic M1; Receptors, Muscarinic; Schizophrenia; Schizophrenic Psychology | 2003 |
Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways.
Topics: Adiponectin; Alanine; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Chromatography, Gel; Cryoelectron Microscopy; Cysteine; Dimerization; Disulfides; Dithiothreitol; Genes, Reporter; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Luciferases; Mice; Molecular Sequence Data; Muscles; Mutagenesis, Site-Directed; NF-kappa B; Protein Conformation; Protein Isoforms; Proteins; Sequence Homology, Amino Acid; Signal Transduction | 2003 |
pH-induced conformational changes of AcrA, the membrane fusion protein of Escherichia coli multidrug efflux system.
Topics: Alanine; Bacterial Outer Membrane Proteins; Biological Transport; Carrier Proteins; Cell Membrane; Cysteine; Drug Resistance, Multiple, Bacterial; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Hydrogen-Ion Concentration; Lipoproteins; Membrane Fusion; Membrane Proteins; Membrane Transport Proteins; Models, Chemical; Multidrug Resistance-Associated Proteins; Plasmids; Protein Conformation; Spectrophotometry; Temperature | 2003 |
Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway.
Topics: Adenocarcinoma; Adenoviridae; Alanine; Apoptosis; Caspases; Cell Adhesion; Cell Death; Cell Line; Cell Line, Tumor; Cell Survival; Cysteine; DNA Fragmentation; DNA, Complementary; Enzyme Activation; Fibronectins; Genes, Dominant; Humans; Immunoblotting; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Integrin beta1; Male; Microscopy, Fluorescence; Microtubule-Associated Proteins; Models, Biological; Neoplasm Proteins; Oligonucleotides, Antisense; Plasmids; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Survivin; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
Role of His-16 in turnover of T4 pyrimidine dimer glycosylase.
Topics: Alanine; Aspartic Acid; Cell Survival; Cysteine; Dimerization; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Glutamic Acid; Histidine; Kinetics; Lysine; Models, Biological; Mutagenesis, Site-Directed; Mutation; Oligonucleotides; Phenotype; Plasmids; Serine; Time Factors; Ultraviolet Rays | 2004 |
Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain.
Topics: Alanine; Amino Acid Transport System A; Amino Acid Transport System ASC; Amino Acid Transport System L; Amino Acid Transport System y+; Animals; beta-Alanine; Blotting, Western; Brain; Brain Chemistry; Cell Line; Cysteine; Dose-Response Relationship, Drug; Embryo, Mammalian; Fusion Regulatory Protein-1; Glycine; Humans; Immunohistochemistry; Kidney; Male; Mice; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sodium; Synaptosomes; Transfection | 2003 |
Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening.
Topics: Alanine; Cells, Cultured; Cysteine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Mutation; Narcotic Antagonists; Receptors, Opioid, mu; Sulfur Radioisotopes | 2003 |
Increased rigidity of domain structures enhances the stability of a mutant enzyme created by directed evolution.
Topics: Alanine; Amino Acid Substitution; Amino Acids; Bacterial Proteins; Cysteine; Directed Molecular Evolution; Dithionitrobenzoic Acid; Enzyme Stability; Hot Temperature; Models, Chemical; Mutagenesis, Site-Directed; Nucleotidyltransferases; Protein Structure, Tertiary; Sulfhydryl Reagents; Thermodynamics | 2003 |
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2.
Topics: Alanine; Angiotensin-Converting Enzyme 2; Carboxypeptidases; Cell Line; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Glutamic Acid; Humans; Inhibitory Concentration 50; Membrane Glycoproteins; Mutation; Peptidyl-Dipeptidase A; Point Mutation; Protein Binding; Protein Structure, Tertiary; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus; Transfection; Viral Envelope Proteins | 2004 |
Effect of pH on the oxidation-reduction properties of thioredoxins.
Topics: Alanine; Animals; Aspartic Acid; Binding Sites; Chlamydomonas reinhardtii; Cysteine; Disulfides; Electron Transport; Escherichia coli Proteins; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Oxidation-Reduction; Protons; Thioredoxin h; Thioredoxins; Tryptophan | 2003 |
Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts.
Topics: 5' Untranslated Regions; Adult; Alanine; Alcoholism; Case-Control Studies; Chi-Square Distribution; Cohort Studies; Cysteine; Female; Gene Frequency; Genetic Variation; Genotype; Glycine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Threonine | 2003 |
Oligosaccharide-peptide ligation of glycosyl thiolates with dehydropeptides: synthesis of S-linked mucin-related glycopeptide conjugates.
Topics: Alanine; Antigens, Tumor-Associated, Carbohydrate; Cysteine; Glycopeptides; Glycosylation; Mucins; Oligosaccharides; Peptides; Stereoisomerism; Sulfhydryl Compounds; Thiogalactosides | 2003 |
Phospholamban binds in a compact and ordered conformation to the Ca-ATPase.
Topics: Alanine; Amino Acid Sequence; Animals; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cysteine; Cytosol; Fluorescence Polarization; Fluorescence Resonance Energy Transfer; Maleimides; Membrane Lipids; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rabbits | 2004 |
Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alanine; Amino Acid Substitution; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cysteine; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Hydrolysis; Kinetics; Mutation; Pertussis Toxin; Protein Binding; Protein Subunits; RGS Proteins; Thermodynamics; Trypsin; Tryptophan | 2004 |
NMR analysis shows that a b-type variant of Hydrogenobacter thermophilus cytochrome c552 retains its native structure.
Topics: Alanine; Amino Acid Sequence; Bacteria, Aerobic; Cysteine; Cytochrome c Group; Heme; Hydrogen; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methionine; Models, Molecular; Molecular Sequence Data; Mutagenesis; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protons; Temperature | 2004 |
Differences in recurrent COL7A1 mutations in dystrophic epidermolysis bullosa: ethnic-specific and worldwide recurrent mutations.
Topics: Alanine; Arginine; Asian People; Collagen Type VII; Cysteine; Epidermolysis Bullosa Dystrophica; Gene Deletion; Gene Frequency; Global Health; Glutamic Acid; Glycine; Humans; Japan; Mutation; Recurrence; United Kingdom | 2004 |
Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase.
Topics: Acetyl Coenzyme A; Alanine; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Carbon Radioisotopes; Catalysis; Coenzyme A Ligases; Cysteine; Decarboxylation; Kinetics; Malonyl Coenzyme A; Molecular Sequence Data; Mutagenesis, Site-Directed; Substrate Specificity | 2004 |
Kinetic characterization of yeast pyruvate carboxylase isozyme Pyc1 and the Pyc1 mutant, C249A.
Topics: Acetyl Coenzyme A; Acetyl-CoA Carboxylase; Adenosine Diphosphate; Alanine; Amino Acid Sequence; Bicarbonates; Carbamyl Phosphate; Carbon-Nitrogen Ligases; Catalysis; Cysteine; Deuterium Exchange Measurement; Escherichia coli Proteins; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; o-Phthalaldehyde; Phosphorylation; Pyruvate Carboxylase; Saccharomyces cerevisiae Proteins; Solvents | 2004 |
Post-translational formylglycine modification of bacterial sulfatases by the radical S-adenosylmethionine protein AtsB.
Topics: Alanine; Amino Acid Motifs; Bacteria; Binding Sites; Chelating Agents; Cysteine; Dose-Response Relationship, Drug; Escherichia coli; Glutathione Transferase; Hydrogen; Iron-Sulfur Proteins; Klebsiella pneumoniae; Models, Chemical; Mutagenesis, Site-Directed; Oxygen; Peptides; Protein Processing, Post-Translational; S-Adenosylmethionine; Sulfatases; Temperature; Time Factors | 2004 |
[Structural analogues of chloromycetin. II. Method of antagonists and synergics in compared study of modes of action of D.L. cysteine and of D.L. beta 2-thienylalanine on E. coli in synthetic medium].
Topics: Alanine; Chloramphenicol; Cysteine; Escherichia coli; Inorganic Chemicals; Organic Chemicals | 1950 |
ADAM family protein Mde10 is essential for development of spore envelopes in the fission yeast Schizosaccharomyces pombe.
Topics: Alanine; Alleles; Amino Acid Sequence; Base Sequence; Binding Sites; Blotting, Northern; Blotting, Southern; Blotting, Western; Catalytic Domain; Cell Membrane; Centrifugation, Density Gradient; Cysteine; DNA, Complementary; Endoplasmic Reticulum; Epitopes; Ethanol; Ether; Fungal Proteins; Gene Deletion; Gene Library; Genotype; Green Fluorescent Proteins; Luminescent Proteins; Meiosis; Metalloproteases; Microscopy, Electron; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Open Reading Frames; Plasmids; Protein Structure, Tertiary; Recombinant Fusion Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Time Factors; Transcription, Genetic | 2004 |
A new procedure for the quantitative splitting of lanthionine to cysteine.
Topics: Alanine; Amino Acids; Cysteine; Sulfides | 1952 |
A covalently linked recombinant albumin dimer is more rapidly cleared in vivo than are wild-type and mutant C34A albumin.
Topics: Alanine; Amino Acid Substitution; Animals; Base Sequence; Cloning, Molecular; Cysteine; Dimerization; DNA Primers; Metabolic Clearance Rate; Mutagenesis, Site-Directed; Pichia; Plasmids; Polymerase Chain Reaction; Rabbits; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Serum Albumin | 2004 |
Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Blotting, Western; Carbon-Sulfur Lyases; Cell Division; Chromatography, High Pressure Liquid; Cysteine; Escherichia coli; Escherichia coli Proteins; Hydro-Lyases; Iron-Sulfur Proteins; Models, Chemical; Molecular Sequence Data; Mutation; Phenotype; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; RNA, Transfer; Subcellular Fractions; Succinate Dehydrogenase; Thionucleotides | 2004 |
S-palmitoylation modulates human estrogen receptor-alpha functions.
Topics: Alanine; Blotting, Western; Cell Membrane; Cysteine; Enzyme Activation; Estrogen Receptor alpha; Gene Deletion; HeLa Cells; Humans; Hypoglycemic Agents; Immunoblotting; Luciferases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Receptors, Estrogen; Signal Transduction; Time Factors; Transcriptional Activation; Transfection | 2004 |
Rescue of protein splicing activity from a Magnetospirillum magnetotacticum intein-like element.
Topics: Alanine; Alternative Splicing; Catalysis; Cysteine; Magnetospirillum; Models, Genetic; Mutation; Phenylalanine; Polymorphism, Genetic; Protein Splicing; Protein Structure, Tertiary; RNA Splicing; Serine; Tyrosine | 2004 |
Conformational changes within the cytosolic portion of phospholamban upon release of Ca-ATPase inhibition.
Topics: Alanine; Amino Acid Sequence; Animals; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cyclic AMP-Dependent Protein Kinases; Cysteine; Cytosol; Enzyme Activation; Enzyme Inhibitors; Fluorescence Polarization; Fluorescence Resonance Energy Transfer; Maleimides; Molecular Sequence Data; Muscle Fibers, Fast-Twitch; Mutagenesis, Site-Directed; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Rabbits | 2004 |
An appraisal of multiple NADPH binding-site models proposed for cytochrome P450 reductase, NO synthase, and related diflavin reductase systems.
Topics: Alanine; Bacillus megaterium; Binding Sites; Catalysis; Cysteine; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; NADP; NADPH-Ferrihemoprotein Reductase; Nitric Oxide Synthase; Oxidation-Reduction; Spectrophotometry; Substrate Specificity | 2004 |
Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3.
Topics: Alanine; Amino Acid Sequence; Blood Platelets; Cell Line; Crystallography, X-Ray; Cysteine; Dimerization; Disulfides; DNA, Complementary; Fibrinogen; Flow Cytometry; Humans; Integrin alphaVbeta3; Lysine; Models, Molecular; Models, Statistical; Molecular Sequence Data; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Software; Structure-Activity Relationship; Thrombasthenia; Transfection | 2004 |
3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism.
Topics: Alanine; Amino Acid Substitution; Catalysis; Colorimetry; Coronavirus 3C Proteases; Cysteine; Cysteine Endopeptidases; Deuterium Exchange Measurement; Endopeptidases; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Serine; Severe acute respiratory syndrome-related coronavirus; Solvents; Substrate Specificity; Temperature; Thermodynamics; Viral Proteins | 2004 |
Possible association of interleukin 1 gene locus polymorphisms with low back pain.
Topics: Adult; Alanine; Alleles; Cohort Studies; Cysteine; Finland; Genetic Predisposition to Disease; Genotype; Glycine; Humans; Interleukin-1; Intervertebral Disc Displacement; Low Back Pain; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Middle Aged; Pain Measurement; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Interleukin; Regression Analysis; Risk; RNA; Surveys and Questionnaires; Threonine | 2004 |
Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein.
Topics: Alanine; Amino Acid Motifs; Amino Acid Substitution; Animals; Bone Morphogenetic Proteins; Cysteine; Drosophila; Drosophila Proteins; Gene Expression Regulation, Developmental; Genes, Insect; Ligands; Microinjections; Point Mutation; Protein Structure, Tertiary; RNA; Sequence Deletion; Structure-Activity Relationship; Tryptophan; Wings, Animal; Xenopus | 2004 |
rBPI(10-193) is secreted by CHO cells and retains the activity of rBPI21.
Topics: Alanine; Amino Acid Substitution; Animals; Antimicrobial Cationic Peptides; Bacteremia; Blood Proteins; CHO Cells; Cricetinae; Cysteine; Disease Models, Animal; Lipopolysaccharides; Membrane Proteins; Mice; Mutagenesis, Site-Directed; Peptide Fragments; Polymerase Chain Reaction; Recombinant Proteins; Staphylococcus aureus; Transfection; Tumor Necrosis Factor-alpha | 2004 |
Evidence for a proton transfer network and a required persulfide-bond-forming cysteine residue in Ni-containing carbon monoxide dehydrogenases.
Topics: Alanine; Aldehyde Oxidoreductases; Asparagine; Bacterial Proteins; Biological Transport; Catalysis; Clostridium; Cysteine; Electron Spin Resonance Spectroscopy; Histidine; Lysine; Multienzyme Complexes; Mutagenesis, Site-Directed; Nickel; Protons; Serine; Sulfides | 2004 |
Electron paramagnetic resonance reveals a large-scale conformational change in the cytoplasmic domain of phospholamban upon binding to the sarcoplasmic reticulum Ca-ATPase.
Topics: Alanine; Animals; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cyclic N-Oxides; Cysteine; Cytoplasm; Disulfides; Electron Spin Resonance Spectroscopy; Lipid Bilayers; Models, Chemical; Mutagenesis, Site-Directed; Phenylalanine; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spin Labels | 2004 |
Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis.
Topics: Alanine; Binding Sites; Cell Line; Cysteine; DNA, Complementary; Epitopes; Humans; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Kinetics; Ligands; Models, Molecular; Mutagenesis; Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary | 2004 |
Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene.
Topics: Adult; Age of Onset; Aged; Alanine; Alleles; Alzheimer Disease; Amyloid Precursor Protein Secretases; Apolipoproteins E; Cysteine; Female; Gene Frequency; Glycine; Haplotypes; Humans; Logistic Models; Male; Membrane Glycoproteins; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Threonine | 2004 |
Temperature-induced structural changes in putidaredoxin: a circular dichroism and UV-VIS absorption study.
Topics: Alanine; Binding Sites; Circular Dichroism; Cysteine; Escherichia coli; Ferredoxins; Hydrogen Bonding; Iron; Oxidation-Reduction; Spectrophotometry; Sulfur; Temperature | 2004 |
Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aggression; Alanine; Alzheimer Disease; Chi-Square Distribution; Cohort Studies; Cysteine; Female; Gene Frequency; Genetic Variation; Genotype; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Genetic; Psychiatric Status Rating Scales; Psychomotor Agitation; Retrospective Studies; Sex Factors; Tryptophan Hydroxylase | 2004 |
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.
Topics: Alanine; Amino Acid Sequence; Autophagy-Related Protein 8 Family; Autophagy-Related Proteins; Binding Sites; Cell Line; Cell Membrane; Cell-Free System; Culture Media; Cysteine; Cysteine Endopeptidases; Escherichia coli; Glutathione Transferase; Green Fluorescent Proteins; HeLa Cells; Humans; Lipids; Luminescent Proteins; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phagocytosis; Phospholipase D; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Receptors, GABA-A; RNA Interference; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Transfection | 2004 |
Role of cysteine residues in the NCKX2 Na+/Ca(2+)-K+ Exchanger: generation of a functional cysteine-free exchanger.
Topics: Alanine; Amino Acid Sequence; Cell Line; Cysteine; Humans; Molecular Sequence Data; Mutagenesis; Precipitin Tests; Retinal Cone Photoreceptor Cells; Serine; Sodium-Calcium Exchanger; Spectrometry, Fluorescence | 2004 |
Cysteine-scanning mutagenesis of the fifth external loop of serotonin transporter.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Biological Transport; Carrier Proteins; Cocaine; Cysteine; Dose-Response Relationship, Drug; Epitopes; HeLa Cells; Humans; Ions; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sodium; Threonine | 2004 |
The fourth transmembrane domain of the Helicobacter pylori Na+/H+ antiporter NhaA faces a water-filled channel required for ion transport.
Topics: Alanine; Amino Acid Sequence; Antiporters; Aspartic Acid; Binding Sites; Cell Membrane; Cysteine; Cytoplasm; DNA; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Helicobacter pylori; Ion Transport; Ions; Kinetics; Leucine; Lithium; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protons; Serine; Sodium-Hydrogen Exchangers; Threonine; Valine; Water | 2004 |
Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.
Topics: Alanine; Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Cell Line; Conserved Sequence; Cysteine; Disulfides; Humans; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Proline; Protein Structure, Tertiary; Protein Subunits; Receptors, Glycine; Tryptophan | 2004 |
The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.
Topics: Alanine; Animals; Cell Line; Cysteine; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Humans; Mice; Mutation; Phenylalanine; Plant Proteins; Point Mutation; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Taste; Taste Buds; Transfection | 2004 |
The effect of sugar, amino acid, metal ion, and NaCl on model Maillard reaction under pH control.
Topics: Alanine; Amino Acids; Arabinose; Arginine; Aspartic Acid; Biochemistry; Carbohydrates; Colorimetry; Copper; Cysteine; Fructose; Glucose; Glutamic Acid; Glycine max; Hot Temperature; Hydrogen-Ion Concentration; Ions; Iron; Isoleucine; Leucine; Lysine; Maltose; Metals; Models, Chemical; Phenylalanine; Proline; Serine; Sodium Chloride; Temperature; Time Factors; Valine; Xylose | 2004 |
Genetic variation in apolipoprotein D and Alzheimer's disease.
Topics: Age of Onset; Aged; Alanine; Alzheimer Disease; Apolipoproteins; Apolipoproteins D; Case-Control Studies; Cysteine; Female; Finland; Gene Frequency; Genetic Variation; Genotype; Glycine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Threonine | 2004 |
The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity.
Topics: Alanine; Cell Line, Tumor; Chloramphenicol O-Acetyltransferase; Cysteine; Genes, Reporter; Glycine; Humans; Linkage Disequilibrium; Neuroblastoma; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptor, Serotonin, 5-HT2A; Threonine; Transfection | 2004 |
Association of estrogen receptor alpha polymorphisms with susceptibility to chronic hepatitis B virus infection.
Topics: Adult; Alanine; Alleles; Asian People; Chromosome Mapping; Cysteine; Estrogen Receptor alpha; Female; Genetic Predisposition to Disease; Haplotypes; Hepatitis B, Chronic; Heterozygote; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Estrogen; Threonine | 2004 |
A novel zinc finger structure in the large subunit of human general transcription factor TFIIE.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Cysteine; DNA Primers; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutathione Transferase; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Transcription Factors, TFII; Transcription, Genetic; Zinc; Zinc Fingers | 2004 |
CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans.
Topics: Aged; Alanine; Black or African American; Case-Control Studies; Confounding Factors, Epidemiologic; Cysteine; Cytochrome P-450 CYP1A1; Female; Genotype; Glycine; Hispanic or Latino; Humans; Linkage Disequilibrium; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; San Francisco; Smoking; Threonine | 2005 |
Alanine and taurine formation from injected cysteine in the rat.
Topics: Alanine; Animals; Cysteine; Cystine; Rats; Taurine | 1950 |
Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis.
Topics: Alanine; Alkynes; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Cystathionine gamma-Lyase; Cysteine; Enzyme Inhibitors; Glyburide; Glycine; Heart Rate; Hydrogen Sulfide; Hypoglycemic Agents; KATP Channels; Liver; Male; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shock, Hemorrhagic | 2004 |
A piezoelectric quartz crystal biosensor: the use of two single cysteine mutants of the periplasmic Escherichia coli glucose/galactose receptor as target proteins for the detection of glucose.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Biosensing Techniques; Crystallization; Cysteine; Escherichia coli Proteins; Glucose; Ligands; Mutagenesis, Site-Directed; Periplasm; Protein Binding; Protein Conformation; Quartz; Receptors, Cell Surface; Surface Properties | 2004 |
Light-induced structural changes of LOV domain-containing polypeptides from Arabidopsis phototropin 1 and 2 studied by small-angle X-ray scattering.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Computer Simulation; Cryptochromes; Cysteine; Dimerization; Escherichia coli; Flavoproteins; Kinetics; Light; Models, Molecular; Molecular Weight; Peptides; Photochemistry; Protein Conformation; Protein Isoforms; Protein Structure, Quaternary; Protein Structure, Tertiary; Recombinant Proteins | 2004 |
Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Carnitine; Carnitine O-Palmitoyltransferase; Catalysis; Cysteine; DNA Primers; Humans; Kinetics; Malonyl Coenzyme A; Models, Chemical; Molecular Sequence Data; Mutagenesis; Mutation; Myocardium; Palmitic Acid; Palmitoylcarnitine; Pichia; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine | 2005 |
Substrate-trapping techniques in the identification of cellular PTP targets.
Topics: Alanine; Aspartic Acid; Catalytic Domain; Cysteine; Glutathione; Mutation; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Serine; Substrate Specificity; Vanadates | 2005 |
Membrane transport proteins with complete replacement of transmembrane helices with polyalanine sequences remain functional.
Topics: Alanine; Amino Acid Sequence; Connexin 43; Cysteine; Gap Junctions; Humans; Kinetics; Membrane Transport Proteins; Models, Molecular; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Oocytes; Peptides; Plasmids; Protein Structure, Secondary | 2005 |
Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.
Topics: Alanine; Amiloride; Amino Acid Sequence; Animals; Binding Sites; Cadmium; Cations; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Electrophysiology; Epithelial Sodium Channels; Mice; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oocytes; Protein Binding; Protein Structure, Tertiary; RNA, Complementary; Sequence Homology, Amino Acid; Serine; Sodium Channels; Time Factors; Xenopus | 2005 |
Identification of a membrane-localized cysteine cluster near the substrate-binding sites of the Streptococcus equisimilis hyaluronan synthase.
Topics: Alanine; Binding Sites; Carbon Isotopes; Cell Membrane; Cysteine; Glucuronosyltransferase; Hyaluronan Synthases; Isotope Labeling; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Serine; Streptococcus equi; Structure-Activity Relationship | 2005 |
Energetics of proton transfer pathways in reaction centers from Rhodobacter sphaeroides. The Glu-H173 activated mutants.
Topics: Alanine; Cysteine; Cytoplasm; Electron Transport; Electrons; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Models, Molecular; Mutation; Nitrogen; Oxidation-Reduction; Oxygen; Protons; Rhodobacter sphaeroides; Software | 2005 |
Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique.
Topics: Alanine; Amino Acid Substitution; Coronavirus 3C Proteases; Cysteine; Cysteine Endopeptidases; Endopeptidases; Fluorescence Resonance Energy Transfer; Histidine; Hydrogen-Ion Concentration; Kinetics; Methionine; Mutagenesis, Site-Directed; Severe acute respiratory syndrome-related coronavirus; Substrate Specificity; Temperature; Viral Proteins | 2005 |
Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain.
Topics: Alanine; Animals; Binding Sites; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cysteine; Models, Molecular; Molecular Structure; Mutation; Nucleotides; Protein Structure, Tertiary; RNA; Substrate Specificity | 2005 |
Identification of residues that contribute to receptor activation through the analysis of compensatory mutations in the G protein-coupled alpha-factor receptor.
Topics: Alanine; Amino Acid Sequence; Cysteine; DNA Mutational Analysis; Genes, Suppressor; Genetic Testing; Mating Factor; Molecular Sequence Data; Mutagenesis; Peptides; Phenylalanine; Receptors, G-Protein-Coupled; Receptors, Mating Factor; Receptors, Peptide; Saccharomyces cerevisiae Proteins; Serine; Signal Transduction; Threonine; Transcription Factors; Tyrosine | 2005 |
Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.
Topics: Alanine; Animals; Benzene Derivatives; Binding Sites; Cell Line; Cell Membrane; Cysteine; Dose-Response Relationship, Drug; Humans; Ligands; Mice; Models, Chemical; Models, Molecular; Mutation; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Taste; Tryptophan | 2005 |
Renin-angiotensin system and haemostasis gene polymorphisms and outcome after coronary artery bypass graft surgery.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Angiotensinogen; Blood Coagulation; Blood Pressure; Coronary Artery Bypass; Coronary Artery Disease; Cysteine; Factor V; Female; Follow-Up Studies; Genotype; Humans; Integrin beta3; Male; Methionine; Middle Aged; Myocardial Contraction; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Stroke Volume; Threonine; Treatment Outcome | 2005 |
Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity.
Topics: Aerobiosis; Alanine; Amino Acid Sequence; Amino Acid Substitution; Anaerobiosis; Animals; Catalysis; Cysteine; Cytochrome Reductases; Dithionite; Electron Transport Complex IV; Flavoproteins; Humans; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Photochemistry; Rats; Structural Homology, Protein | 2005 |
Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant.
Topics: Alanine; Amino Acid Substitution; Apoptosis; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cysteine; Dependovirus; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Mitosis; Mutation, Missense; Neoplasm Proteins; Survivin | 2005 |
Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Blotting, Western; Cell Membrane; Cysteine; Dimerization; Dose-Response Relationship, Drug; Electrophysiology; Gene Deletion; GluK2 Kainate Receptor; Immunoprecipitation; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Oocytes; Phenotype; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; RNA, Complementary; Sequence Homology, Amino Acid; Software | 2005 |
Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.
Topics: Alanine; Amino Acid Sequence; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cysteine; DNA Primers; Genes, Tumor Suppressor; Glycine; Humans; In Situ Nick-End Labeling; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Promoter Regions, Genetic; Protein Biosynthesis; Protein Prenylation; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Sequence Homology, Amino Acid; Serine; Tetrazolium Salts; Thiazoles; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2005 |
Denaturant-assisted formation of a stabilizing disulfide bridge from engineered cysteines in nonideal conformations.
Topics: Alanine; Carbonic Anhydrase II; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Entropy; Enzyme Stability; Guanidine; Humans; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Neisseria gonorrhoeae; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Software; Structure-Activity Relationship | 2005 |
Crystal structure of S-ribosylhomocysteinase (LuxS) in complex with a catalytic 2-ketone intermediate.
Topics: Alanine; Arginine; Bacillus subtilis; Bacterial Proteins; Binding Sites; Carbon-Sulfur Lyases; Catalysis; Cobalt; Crystallization; Crystallography, X-Ray; Cysteine; Ferrous Compounds; Histidine; Homocysteine; Hydrolases; Ketones; Models, Molecular; Mutagenesis, Site-Directed; Serine; Spectrophotometry, Ultraviolet; Substrate Specificity; Vibrio | 2005 |
Probing the oligomeric state of phospholamban variants in phospholipid bilayers from solid-state NMR measurements of rotational diffusion rates.
Topics: Alanine; Amino Acid Sequence; Calcium-Binding Proteins; Carbon Isotopes; Cysteine; Deuterium Exchange Measurement; Dimyristoylphosphatidylcholine; Electrophoresis, Polyacrylamide Gel; Genetic Variation; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Proteins; Models, Chemical; Molecular Sequence Data; Phospholipids; Phosphorus Isotopes; Thermodynamics | 2005 |
Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.
Topics: Alanine; Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Amino Acids; Amino Acids, Aromatic; Animals; Arginine; Biological Transport; Blotting, Northern; Blotting, Western; Cell Lineage; Chickens; Cloning, Molecular; Cysteine; Dimerization; DNA, Complementary; Dogs; Dose-Response Relationship, Drug; Evolution, Molecular; Gene Library; Gene Silencing; Glutamine; Glycine; HeLa Cells; Humans; In Situ Hybridization; Inhibitory Concentration 50; Intestine, Small; Kidney; Kinetics; Levodopa; Mice; Molecular Sequence Data; Open Reading Frames; Pan troglodytes; Phylogeny; Proline; Protein Binding; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sodium; Transfection | 2005 |
Serine 16 phosphorylation induces an order-to-disorder transition in monomeric phospholamban.
Topics: Alanine; Amino Acid Sequence; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cysteine; Enzyme Inhibitors; Molecular Sequence Data; Mutation; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Protein Conformation; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serine; Solutions; Structure-Activity Relationship; Thermodynamics | 2005 |
Substitution of the cysteine 438 residue in the cytoplasmic tail of the glucagon-like peptide-1 receptor alters signal transduction activity.
Topics: Adenylyl Cyclases; Alanine; Animals; CHO Cells; Consensus Sequence; Cricetinae; Cyclic AMP; Cysteine; Cytoplasm; Endocytosis; Female; Glucagon-Like Peptide-1 Receptor; GTP-Binding Proteins; Mutagenesis, Site-Directed; Mutation; Palmitates; Protein Kinase C; Rats; Receptors, Glucagon; Serine; Signal Transduction; Transfection | 2005 |
Dilated cardiomyopathy may be an early sign of the C826A Fukutin-related protein mutation.
Topics: Adult; Alanine; Cardiomyopathy, Dilated; Creatine Kinase; Cysteine; DNA Mutational Analysis; Genetic Linkage; Humans; Leg; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Mutation; Pentosyltransferases; Phenotype; Proteins; Siblings | 2005 |
Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect.
Topics: Alanine; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cysteine; Cytoplasm; Dimerization; Diploidy; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Glutathione Transferase; Histidine; Humans; Keratinocytes; Mice; Microscopy, Confocal; Mink; Mutation; Protein Kinases; Recombinant Fusion Proteins; RNA, Small Interfering; Time Factors; Transfection; Tumor Suppressor Proteins | 2005 |
[Anti-oxidative effect of ribonuclease inhibitor by site-directed mutagenesis and expression in Pichia pastoris].
Topics: Alanine; Amino Acid Substitution; Antioxidants; Blotting, Western; Catalysis; Cysteine; Electroporation; Enzyme Inhibitors; Gene Expression; Humans; Hydrogen Peroxide; Mutagenesis, Site-Directed; Mutation; Pichia; Placental Hormones; Plasmids; Recombinant Proteins; Ribonuclease, Pancreatic; Transformation, Genetic | 2005 |
Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alanine; Benzylamines; Binding Sites; Catalysis; Cyclopropanes; Cysteine; Flavins; Humans; Kynuramine; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Pichia; Recombinant Proteins; Serotonin; Substrate Specificity; Sulfhydryl Compounds | 2005 |
The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide.
Topics: Alanine; Alkylating Agents; Amino Acid Substitution; Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Cysteine; Disulfides; Hemagglutinins; Humans; Hydrolysis; Macrophages; Maleimides; Metalloendopeptidases; Peptide Fragments; Polyethylene Glycols; Protein Denaturation; Recombinant Proteins; Sterol O-Acyltransferase; Sulfhydryl Compounds | 2005 |
Point mutations at the type I Cu ligands, Cys457 and Met467, and at the putative proton donor, Asp105, in Myrothecium verrucaria bilirubin oxidase and reactions with dioxygen.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Copper; Cysteine; Dithionite; Fungal Proteins; Glutamic Acid; Glutamine; Hypocreales; Ligands; Methionine; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Point Mutation; Protons; Serine | 2005 |
Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe.
Topics: Alanine; Alleles; Amino Acid Sequence; Cysteine; Dimerization; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; GATA Transcription Factors; Gene Expression Regulation, Fungal; Green Fluorescent Proteins; Homeostasis; Iron; Kinetics; Leucine; Models, Genetic; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA, Messenger; Schizosaccharomyces pombe Proteins; Transcription Factors; Transcription, Genetic; Zinc Fingers | 2005 |
Functional analysis of recombinant Bbeta15C and Bbeta15A fibrinogens demonstrates that Bbeta15G residue plays important roles in FPB release and in lateral aggregation of protofibrils.
Topics: Alanine; Animals; Batroxobin; Blotting, Western; Catalysis; Chromatography, High Pressure Liquid; Cysteine; Dimerization; Disulfides; Electrophoresis, Polyacrylamide Gel; Fibrin; Fibrinogen; Fibrinopeptide B; Glycine; Heterozygote; Humans; Immunoblotting; Kinetics; Microscopy, Electron, Scanning; Mutagenesis; Protein Binding; Recombinant Proteins; Snake Venoms; Thrombin; Time Factors | 2005 |
Mechanism of zinc coordination by point-mutated structures of the distal CCHC binding motif of the HIV-1 NCp7 protein.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Capsid Proteins; Cysteine; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; Histidine; HIV-1; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Sequence Data; Peptide Fragments; Point Mutation; Protein Binding; Serine; Spectrometry, Fluorescence; Viral Proteins; Zinc | 2005 |
Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Calcium; Catalytic Domain; Crystallography, X-Ray; Cysteine; Glycine; Humans; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutation, Missense; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Oxygen; Protein Structure, Secondary; Sequence Homology, Amino Acid; Sphingolipidoses; Sulfatases; Tumor Cells, Cultured | 2005 |
Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching.
Topics: Adaptation, Physiological; Alanine; Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Chemotaxis; Conserved Sequence; Cysteine; Cytoplasm; Disulfides; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Glycine; Histidine Kinase; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Receptors, Amino Acid; Salmonella typhimurium; Signal Transduction | 2005 |
The crystal structure of Mlc, a global regulator of sugar metabolism in Escherichia coli.
Topics: Alanine; Arthrobacter; Bacillus subtilis; beta-Galactosidase; Binding Sites; Carbohydrate Metabolism; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Databases, Protein; Dimerization; Escherichia coli; Escherichia coli Proteins; Fructokinases; Glucokinase; Glucose; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Repressor Proteins; Serine; Transcription, Genetic; Zinc | 2005 |
Agrobacterium phytochrome as an enzyme for the production of ZZE bilins.
Topics: Agrobacterium tumefaciens; Alanine; Amino Acid Substitution; Bacterial Proteins; Bile Pigments; Biliverdine; Chromatography, High Pressure Liquid; Cysteine; Isomerism; Light; Methanol; Photochemistry; Photoreceptors, Microbial; Phycobilins; Phycocyanin; Phytochrome; Protein Kinases; Protein Processing, Post-Translational; Pyrroles; Spectrophotometry, Ultraviolet; Tetrapyrroles | 2005 |
D-Serine uptake by isolated retinas is consistent with ASCT-mediated transport.
Topics: 4-Chloro-7-nitrobenzofurazan; Alanine; Ambystoma; Amino Acid Transport System ASC; Animals; Biological Transport; Cysteine; Electrophoresis, Capillary; In Vitro Techniques; Retina; Serine; Sodium; Threonine; Time Factors | 2005 |
SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels.
Topics: Adult; Alanine; Conserved Sequence; Cysteine; Erythromelalgia; Female; Genes, Dominant; Heterozygote; Humans; Male; Mutation; Mutation, Missense; NAV1.7 Voltage-Gated Sodium Channel; Nervous System Diseases; Pedigree; Polymorphism, Genetic; Sodium Channels; Threonine | 2005 |
Versatile and stereoselective syntheses of orthogonally protected beta-methylcysteine and beta-methyllanthionine.
Topics: Alanine; Amino Acid Sequence; Aziridines; Catalysis; Cysteine; Molecular Structure; Stereoisomerism; Sulfides; Threonine | 2005 |
The melanocortin-1 receptor carboxyl terminal pentapeptide is essential for MC1R function and expression on the cell surface.
Topics: Alanine; Amino Acid Sequence; Cell Line; Cell Membrane; Cysteine; Flow Cytometry; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Protein Binding; Receptor, Melanocortin, Type 1; Sequence Deletion; Transfection | 2005 |
Isolation and characterization of hemolymph antifreeze proteins from larvae of the longhorn beetle Rhagium inquisitor (L.).
Topics: Alanine; Amino Acids; Animals; Antifreeze Proteins; Arginine; Cations; Chromatography, Ion Exchange; Coleoptera; Cysteine; Glycine; Hemolymph; Isoelectric Focusing; Larva; Mass Spectrometry; Threonine | 2005 |
Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation.
Topics: Alanine; Antigens, CD; Antigens, Differentiation; B7-1 Antigen; B7-2 Antigen; Cell Line, Transformed; CTLA-4 Antigen; Cysteine; Dimerization; Disulfides; Glycosylation; Humans; Immunosuppressive Agents; Jurkat Cells; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Membrane Microdomains; Point Mutation; Protein Binding; T-Lymphocytes | 2005 |
Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Brain; Catalysis; Catalytic Domain; Cattle; Chlorocebus aethiops; Chromatography; COS Cells; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Histidine; Humans; Immunoblotting; Kidney; Lysosomes; Macrophages; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Open Reading Frames; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Phospholipids; Plasmids; Pulmonary Surfactants; Rats; Sequence Homology, Amino Acid; Serine; Surface-Active Agents; Transfection | 2005 |
A crystallographic study of Cys69Ala flavodoxin II from Azotobacter vinelandii: structural determinants of redox potential.
Topics: Alanine; Amino Acid Sequence; Azotobacter vinelandii; Binding Sites; Crystallography, X-Ray; Cysteine; Flavin Mononucleotide; Flavodoxin; Glycine; Hydrogen Bonding; Leucine; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Sequence Homology, Amino Acid; Structural Homology, Protein; Tryptophan | 2005 |
The prevalence of C807T mutation of glycoprotein Ia gene among young male survivors of myocardial infarction: a relation with coronary angiography results.
Topics: Adult; Alanine; Case-Control Studies; Coronary Angiography; Cysteine; Gene Expression; Gene Frequency; Genetic Predisposition to Disease; Humans; Integrin alpha2; Male; Middle Aged; Mutation; Myocardial Infarction; Polymorphism, Genetic; Threonine | 2005 |
Association of the 1438G/A and 102T/C polymorphism of the 5-HT2A receptor gene with irritable bowel syndrome 5-HT2A gene polymorphism in irritable bowel syndrome.
Topics: Alanine; Case-Control Studies; Cysteine; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glycine; Humans; Irritable Bowel Syndrome; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2A; Threonine | 2005 |
Essential cysteine residues in Bacillus subtilis spore photoproduct lyase identified by alanine scanning mutagenesis.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Bacillus subtilis; Conserved Sequence; Cysteine; Molecular Sequence Data; Mutagenesis, Site-Directed; Proteins; Sequence Homology, Amino Acid; Spectrum Analysis | 2005 |
Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alanine; Barrett Esophagus; Cardia; Case-Control Studies; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Cysteine; DNA, Neoplasm; Esophageal Neoplasms; Female; Gene Frequency; Glycine; Homozygote; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Stomach Neoplasms | 2005 |
Plasma amino acid concentrations in patients with coronary heart disease: a comparison between U.K. Indian Asian and Caucasian men.
Topics: Alanine; Asian People; Biomarkers; Blood Glucose; Coronary Disease; Cysteine; Feeding Behavior; Humans; Male; Middle Aged; White People | 2005 |
Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant.
Topics: Alanine; Amino Acid Motifs; Animals; Binding Sites; Chlorocebus aethiops; Consensus Sequence; COS Cells; Cysteine; Intracellular Signaling Peptides and Proteins; Mice; Mutation; NIH 3T3 Cells; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Substrate Specificity; Threonine; Vanadates | 2006 |
Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa.
Topics: Alanine; Anti-Infective Agents; Betaine-Aldehyde Dehydrogenase; Binding Sites; Catalysis; Chromatography; Cysteine; Disulfiram; Dithionitrobenzoic Acid; Enzyme Inhibitors; Glutathione; Kinetics; Methyl Methanesulfonate; Models, Chemical; Mutagenesis, Site-Directed; Mutation; NADP; Protein Conformation; Protein Structure, Quaternary; Proteins; Pseudomonas aeruginosa; Sulfhydryl Compounds; Temperature; Time Factors | 2006 |
Is there a folate-related gene-environment interaction in the etiology of childhood acute lymphoblastic leukemia?
Topics: Alanine; Bone Marrow; Child; Child, Preschool; Cysteine; Dietary Supplements; DNA, Neoplasm; Female; Folic Acid; Genotype; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Threonine | 2006 |
Engineering artificially split inteins for applications in protein chemistry: biochemical characterization of the split Ssp DnaB intein and comparison to the split Sce VMA intein.
Topics: Adenosine Triphosphatases; Alanine; Bacterial Proteins; Base Sequence; Cysteine; Dimerization; DNA Helicases; DnaB Helicases; Inteins; Kinetics; Mutation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Splicing; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Synechocystis; Temperature | 2006 |
Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Cysteine; Cytosol; Endocytosis; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins; HeLa Cells; Humans; Leucine; Lysosomes; Microscopy, Confocal; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Protein Structure, Tertiary; Protein Transport; Recombinant Proteins; Transient Receptor Potential Channels; TRPM Cation Channels | 2006 |
Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement.
Topics: Adolescent; Alanine; Angiotensinogen; Child; Child, Preschool; Cysteine; DNA Transposable Elements; Female; Gene Deletion; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; IgA Vasculitis; Kidney Diseases; Male; Methionine; Nephrotic Syndrome; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Proteinuria; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Severity of Illness Index; Threonine | 2006 |
Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.
Topics: Alanine; Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Cysteine; Erythromycin; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide | 2006 |
Fluorescence energy transfer studies of human deoxycytidine kinase: role of cysteine 185 in the conformational changes that occur upon substrate binding.
Topics: Alanine; Binding Sites; Cysteine; Deoxycytidine Kinase; Energy Transfer; Enzyme Activation; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Kinetics; Maleimides; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Nucleosides; Phosphates; Protein Binding; Protein Conformation; Substrate Specificity; Tryptophan | 2006 |
Analysis of the three dimensional structure of the CXGXC motif in the CMGCC and CAGYC regions of alpha-and beta-subunits of human chorionic gonadotropin: importance of glycine residue (G) in the motif.
Topics: Alanine; Amino Acid Motifs; Chorionic Gonadotropin, beta Subunit, Human; Computer Simulation; Cysteine; Glycine; Glycoprotein Hormones, alpha Subunit; Humans; Protein Conformation; Protein Structure, Tertiary | 2006 |
[Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke].
Topics: Adult; Aged; Alanine; Alleles; Brain Ischemia; Cysteine; Female; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Risk Assessment; Risk Factors; Sequence Analysis, DNA; Stroke; Threonine | 2006 |
Biochemical characterization of Drosophila gamma-glutamyl carboxylase and its role in fly development.
Topics: Alanine; Amino Acid Substitution; Animals; Carbon-Carbon Ligases; Cell Line; Cysteine; Drosophila; Fertility; Humans; Mutagenesis, Site-Directed; Peptides; Vitamin K | 2006 |
Comparative species utilization and toxicity of sulfur amino acids.
Topics: Alanine; Amino Acids, Sulfur; Animals; Biological Availability; Cysteine; Cystine; Dietary Supplements; Glutathione; Homocysteine; Humans; Hydroxylation; Isomerism; Methionine; Species Specificity; Sulfides; Taurine; Vitamin U | 2006 |
Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations.
Topics: Alanine; Amino Acid Sequence; Animals; Cell Membrane; Cysteine; Dimerization; Disulfides; Drosophila melanogaster; Drosophila Proteins; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Humans; Molecular Sequence Data; Multiple Endocrine Neoplasia Type 2a; Mutation; Protein Binding; Proto-Oncogene Proteins c-ret; Sequence Alignment; Sequence Homology, Amino Acid; Thyroid Neoplasms | 2006 |
Stereoselective synthesis of orthogonally protected alpha-methylnorlanthionine.
Topics: Alanine; Amino Acids; Catalysis; Cysteine; Molecular Structure; Nisin; Peptides, Cyclic; Stereoisomerism; Sulfides | 2006 |
Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Cysteine; Female; Glutamic Acid; Glycine; Humans; Leucine; Male; Middle Aged; Multivariate Analysis; Mutation; Phenylalanine; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Receptor, Fibroblast Growth Factor, Type 3; Sequence Analysis, DNA; Serine; Tyrosine; Urinary Bladder Neoplasms | 2006 |
Drosophila nuclear receptor E75 is a thiolate hemoprotein.
Topics: Alanine; Amino Acid Sequence; Animals; Cysteine; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Electron Spin Resonance Spectroscopy; Gene Expression; Heme; Hemeproteins; Histidine; Humans; Ligands; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Sequence Alignment; Solubility; Spectrophotometry, Ultraviolet; Sulfur; Transcription Factors | 2006 |
DNA-repair gene polymorphisms predict favorable clinical outcome among patients with advanced squamous cell carcinoma of the head and neck treated with cisplatin-based induction chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Combined Chemotherapy Protocols; Arginine; Asparagine; Aspartic Acid; Carcinoma, Squamous Cell; Cisplatin; Cysteine; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Endonucleases; Female; Gene Frequency; Genotype; Glutamine; Head and Neck Neoplasms; Humans; Lysine; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Survival Analysis; Treatment Outcome; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein | 2006 |
S100A8 triggers oxidation-sensitive repulsion of neutrophils.
Topics: Alanine; Animals; Calgranulin A; Cells, Cultured; Chemotaxis, Leukocyte; Cysteine; Flow Cytometry; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Rats; Recombinant Proteins | 2006 |
Molecular dynamics simulations of Hydrogenobacter thermophilus cytochrome c552: comparisons of the wild-type protein, a b-type variant, and the apo state.
Topics: Alanine; Apoproteins; Bacterial Proteins; Binding Sites; Cysteine; Cytochrome c Group; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Structure, Secondary | 2006 |
Determination of the gas-phase acidities of cysteine-polyalanine peptides using the extended kinetic method.
Topics: Alanine; Carboxylic Acids; Cysteine; Entropy; Gases; Kinetics; Peptide Mapping; Peptides; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds | 2007 |
Re: Response of a KIT-positive extra-abdominal fibromatosis to imatinib mesylate and KIT genetic analysis.
Topics: Alanine; Antineoplastic Agents; Benzamides; Biomarkers, Tumor; Cysteine; Fibroma; Humans; Imatinib Mesylate; Leucine; Methionine; Mutagenesis; Mutation; Piperazines; Polymorphism, Genetic; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Treatment Outcome | 2006 |
Cys303 in the histidine kinase PhoR is crucial for the phosphotransfer reaction in the PhoPR two-component system in Bacillus subtilis.
Topics: Alanine; Bacillus subtilis; Bacterial Proteins; Cysteine; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Bacterial; Histidine Kinase; Mutation; Operon; Phosphorylation; Plasmids; Protein Kinases; Signal Transduction | 2007 |
Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress.
Topics: Activating Transcription Factor 6; Alanine; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cricetulus; Cysteine; Disulfides; Endoplasmic Reticulum; Golgi Apparatus; Humans; Mice; Models, Biological; Molecular Sequence Data; Oxidation-Reduction; Proprotein Convertases; Protein Processing, Post-Translational; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Transport; Sequence Alignment; Serine Endopeptidases; Structure-Activity Relationship; Substrate Specificity; Tunicamycin | 2007 |
The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity.
Topics: Alanine; Blotting, Western; Carrier Proteins; Cells, Cultured; cis-trans-Isomerases; Cysteine; Eye Proteins; Genetic Vectors; Humans; Mutagenesis, Site-Directed; Palmitates; Pigment Epithelium of Eye; Subcellular Fractions | 2006 |
Regulation of the arsenic-responsive transcription factor Yap8p involves the ubiquitin-proteasome pathway.
Topics: Alanine; Amino Acid Substitution; Arsenic; Arsenites; Basic-Leucine Zipper Transcription Factors; beta-Galactosidase; Blotting, Western; Cysteine; Dimerization; Dose-Response Relationship, Drug; Gene Expression Regulation, Fungal; Genes, Fungal; Plasmids; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcriptional Activation; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2007 |
Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Cysteine; Escherichia coli; Hepacivirus; Protein Denaturation; Protein Precursors; Protein Structure, Tertiary; Viral Nonstructural Proteins; Zinc | 2007 |
Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity.
Topics: Adenylyl Cyclases; Alanine; Animals; Baculoviridae; Cell Line; Cell Membrane; Cysteine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gs; Guanidine; Guanosine Triphosphate; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; Humans; Mutation, Missense; Receptors, Histamine H2; Recombinant Fusion Proteins; Species Specificity; Spodoptera; Transfection | 2007 |
Rhenium analogues of promising renal imaging agents with a [99mTc(CO)3]+ core bound to cysteine-derived dipeptides, including lanthionine.
Topics: Alanine; Crystallography, X-Ray; Cysteine; Dipeptides; Kidney; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Organometallic Compounds; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Rhenium; Sensitivity and Specificity; Sulfides | 2007 |
DFT studies using supercells and projector-augmented waves for structure, energetics, and dynamics of glycine, alanine, and cysteine.
Topics: Alanine; Cysteine; Glycine; Hydrogen Bonding; Models, Molecular; Molecular Structure; Quantum Theory; Spectrophotometry, Infrared | 2007 |
Alanine scanning and Fe-BABE probing of the bacteriophage ø29 prohead RNA-connector interaction.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Bacteriophages; Base Sequence; Capsid Proteins; Cysteine; DNA Packaging; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Hydroxyl Radical; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Mutation; Nucleic Acid Conformation; Protein Binding; RNA, Viral; Sequence Alignment | 2007 |
Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation.
Topics: Alanine; Allosteric Regulation; Amino Acid Sequence; Anesthetics, Inhalation; Animals; Binding Sites; Cysteine; Ethanol; Female; In Vitro Techniques; Ion Channel Gating; Lysine; Molecular Sequence Data; Mutation; Oocytes; Proline; Protein Structure, Tertiary; Protein Subunits; Receptors, Glycine; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Sequence Alignment; Signal Transduction; Xenopus laevis | 2007 |
Complementation of an E. coli cysteine auxotrophic mutant for the structural modification study of 3'(2'),5'-bisphosphate nucleotidase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Arabidopsis Proteins; Base Sequence; Cysteine; Cytosine; Escherichia coli; Genetic Complementation Test; Molecular Sequence Data; Mutagenesis; Mutation; Nucleotidases; Phosphoric Monoester Hydrolases; Sequence Homology, Amino Acid; Thymine; Valine | 2007 |
Electronic excitations of glycine, alanine, and cysteine conformers from first-principles calculations.
Topics: Alanine; Cysteine; Glycine; Models, Molecular; Molecular Conformation | 2007 |
Characterization of transport systems for cysteine, lysine, alanine, and leucine in wool follicles of sheep.
Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Animals; Biological Transport; Cysteine; Hair Follicle; Kinetics; Leucine; Lysine; Sheep; Tissue Culture Techniques; Wool | 2007 |
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
Topics: Alanine; Amino Acid Substitution; Antigens, Neoplasm; Benzoquinones; Cysteine; DNA Cleavage; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Superhelical; Etoposide; Humans; Kinetics; Mass Spectrometry; Models, Molecular; Mutant Proteins; Mutation; Protein Structure, Tertiary; Quinones; Recombinant Proteins; Temperature | 2007 |
Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter.
Topics: Alanine; Animals; Aspartic Acid; Binding Sites; Cysteine; Dicarboxylic Acid Transporters; Excitatory Amino Acid Transporter 3; Glutamic Acid; HeLa Cells; Humans; Microinjections; Mutation; Neurons; Oocytes; Protein Conformation; Protein Structure, Tertiary; Rabbits; Serine; Succinic Acid; Transfection; Xenopus laevis | 2007 |
Hair is the news.
Topics: Alanine; Amino Acids; Ammonia; Animals; Cysteine; Hair; Hair Follicle; Humans; Sulfides | 2007 |
Docking of the periplasmic FecB binding protein to the FecCD transmembrane proteins in the ferric citrate transport system of Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Arginine; ATP-Binding Cassette Transporters; Biological Transport; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Ferric Compounds; Gene Expression Regulation, Bacterial; Glutamic Acid; Hydrogen Bonding; Ion Pumps; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Polymerase Chain Reaction; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Structure-Activity Relationship | 2007 |
Substitution of conserved cysteine residues in wheat streak mosaic virus HC-Pro abolishes virus transmission by the wheat curl mite.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arachnid Vectors; Cysteine; Cysteine Endopeptidases; Mites; Potyviridae; Sequence Alignment; Triticum; Viral Proteins | 2007 |
Effects of Ala substitution for conserved Cys residues in mouse ileal and hepatic Na+-dependent bile acid transporters.
Topics: Alanine; Amino Acid Substitution; Animals; Bile Acids and Salts; Conserved Sequence; Cysteine; Ileum; Kinetics; Liver; Mice; Mutation, Missense; Organic Anion Transporters, Sodium-Dependent; Symporters; Taurocholic Acid | 2007 |
Molecular mechanism of oxidative stress perception by the Orp1 protein.
Topics: Alanine; Binding Sites; Cysteine; Disulfides; Genetic Complementation Test; Glutathione Peroxidase; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Mutation; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Phenylalanine; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sulfenic Acids; Transcription Factors | 2007 |
Conformation, dynamics, and insertion of a noncysteine-containing protegrin-1 analogue in lipid membranes from solid-state NMR spectroscopy.
Topics: Alanine; Amino Acid Sequence; Anti-Infective Agents; Antimicrobial Cationic Peptides; Carbon Radioisotopes; Cell Membrane; Cholesterol; Cysteine; Disulfides; Lipid Bilayers; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylglycerols; Protein Conformation; Proteins | 2007 |
Structural studies on Vibrio cholerae ToxR periplasmic and cytoplasmic domains.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Cysteine; Cytoplasm; Dimerization; Disulfides; DNA-Binding Proteins; Escherichia coli; Molecular Sequence Data; Mutagenesis, Site-Directed; Periplasmic Proteins; Protein Structure, Tertiary; Transcription Factors; Vibrio cholerae | 2007 |
The natural product avrainvillamide binds to the oncoprotein nucleophosmin.
Topics: Alanine; Animals; Antineoplastic Agents; Binding Sites; Biological Products; Biotin; Blotting, Western; Chlorocebus aethiops; COS Cells; Cysteine; HeLa Cells; Humans; Indoles; Microscopy, Fluorescence; Nuclear Proteins; Nucleophosmin; Oncogene Proteins; Tumor Cells, Cultured | 2007 |
Novel mutations in exon 6 of the GFAP gene affect a highly conserved if motif in the rod domain 2B and are associated with early onset infantile Alexander disease.
Topics: Age of Onset; Alanine; Alexander Disease; Cysteine; DNA Mutational Analysis; Exons; Female; Frontal Lobe; Glial Fibrillary Acidic Protein; Humans; Infant; Magnetic Resonance Imaging; Male; Mutation; Protein Structure, Tertiary; Tyrosine; Valine | 2007 |
F413C and A531V but not R894X myotonia congenita mutations cause defective endoplasmic reticulum export of the muscle-specific chloride channel CLC-1.
Topics: Alanine; Amino Acids; Animals; Arginine; Cells, Cultured; Chloride Channels; Coatomer Protein; Cysteine; Endoplasmic Reticulum; Female; Humans; Immunoprecipitation; Muscle Cells; Muscle Proteins; Mutation; Oligonucleotides, Antisense; Phenylalanine; Protein Transport; Rats; Rats, Sprague-Dawley; Transfection; Valine | 2008 |
Cysteine 10 is critical for the activity of Ochrobactrum anthropi glutathione transferase and its mutation to alanine causes the preferential binding of glutathione to the H-site.
Topics: Alanine; Bacterial Proteins; Binding Sites; Cysteine; Glutathione; Glutathione Transferase; Mutation, Missense; Ochrobactrum anthropi | 2008 |
Identifying the presence of a disulfide linkage in peptides by the selective elimination of hydrogen disulfide from collisionally activated alkali and alkaline earth metal complexes.
Topics: Alanine; Animals; Cations; Cysteine; Disulfides; Gastric Mucosa; Hydrogen Sulfide; Insulin; Intestinal Mucosa; Metals; Models, Chemical; Peptides; Spectrometry, Mass, Electrospray Ionization; Swine; Vasopressins | 2008 |
Functional and structural roles of conserved cysteine residues in the carboxyl-terminal domain of the follicle-stimulating hormone receptor in human embryonic kidney 293 cells.
Topics: Alanine; Amino Acid Sequence; Cell Line; Computer Simulation; Cyclic AMP; Cysteine; Humans; Kidney; Lipoylation; Molecular Sequence Data; Mutation; Receptors, FSH; Serine; Threonine | 2008 |
Dehydroalanine derived from cysteine is a common post-translational modification in human serum albumin.
Topics: Alanine; Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Humans; Models, Chemical; Molecular Sequence Data; Molecular Structure; Protein Processing, Post-Translational; Serum Albumin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2008 |
Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: versatile and switchable access to functionalized proteins.
Topics: Alanine; Alkylation; Cysteine; Models, Molecular; Molecular Structure; Protein Processing, Post-Translational; Proteins; Spectrometry, Mass, Electrospray Ionization; Surface Properties | 2008 |
TNF-alpha-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells.
Topics: Alanine; Animals; Bacterial Proteins; Biomarkers, Tumor; Blotting, Western; Carcinogens; Chronic Disease; Cysteine; Flow Cytometry; Gastric Mucosa; Gastritis; Gene Expression Regulation, Neoplastic; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Japan; Mice; Microscopy, Confocal; Mutation; NF-kappa B; Recombinant Proteins; Stomach Neoplasms; Tumor Necrosis Factor-alpha | 2008 |
Role of disulfide bonds in goose-type lysozyme.
Topics: Alanine; Animals; Biochemistry; Catalysis; Cysteine; Disulfides; Geese; Hydrogen-Ion Concentration; Models, Molecular; Muramidase; Mutation; Protein Conformation; Serine; Struthioniformes; Temperature | 2008 |
Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases.
Topics: Alanine; Aldehydes; Animals; Binding Sites; Cloning, Molecular; Cysteine; Drosophila Proteins; Enzyme Inhibitors; Escherichia coli Proteins; gamma-Aminobutyric Acid; Hydrocarbons, Aromatic; NAD; NADP; Nuclear Magnetic Resonance, Biomolecular; Substrate Specificity; Succinate-Semialdehyde Dehydrogenase | 2008 |
Mutagenesis of the cysteine-rich clip domain in the Drosophila patterning protease, Snake.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Animals; Catalysis; Catalytic Domain; Cysteine; Drosophila; Drosophila Proteins; Embryo, Nonmammalian; Molecular Sequence Data; Mutagenesis; Protein Structure, Secondary; Protein Structure, Tertiary; RNA, Messenger; Serine Endopeptidases | 2008 |
Ribosomal synthesis of bicyclic peptides via two orthogonal inter-side-chain reactions.
Topics: Alanine; Alkynes; Amino Acid Sequence; Amino Acids; Aminobutyrates; Codon; Cysteine; Glycine; Peptides, Cyclic; Ribosomes; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Templates, Genetic | 2008 |
Stereoselective synthesis of triply isotope-labeled Ser, Cys, and Ala: amino acids for stereoarray isotope labeling technology.
Topics: Alanine; Amino Acids; Cysteine; Isotope Labeling; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Biology; Serine; Stereoisomerism | 2008 |
Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies.
Topics: Alanine; Animals; Animals, Newborn; Calbindins; Calcium Channels, N-Type; Cells, Cultured; Cysteine; Disease Models, Animal; Glycine; Green Fluorescent Proteins; Ion Channel Gating; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Molecular; Mutation; Nervous System Diseases; Patch-Clamp Techniques; Purkinje Cells; S100 Calcium Binding Protein G; Silver Staining; Threonine; Tyrosine 3-Monooxygenase | 2008 |
Only five of 10 strictly conserved disulfide bonds are essential for folding and eight for function of the HIV-1 envelope glycoprotein.
Topics: Alanine; CD4-Positive T-Lymphocytes; Cysteine; Disulfides; Endoplasmic Reticulum; HeLa Cells; HIV Envelope Protein gp120; HIV Envelope Protein gp160; Humans; Mutagenesis, Site-Directed; Oxygen; Protein Binding; Protein Folding; Protein Structure, Tertiary; Protein Transport | 2008 |
Dispensable residues in the active site of the cytochrome c biogenesis protein CcmH.
Topics: Aerobiosis; Alanine; Amino Acid Sequence; Amino Acid Substitution; Bacterial Outer Membrane Proteins; Binding Sites; Conserved Sequence; Cysteine; Cytochromes c; Escherichia coli; Escherichia coli Proteins; Protein Structure, Tertiary | 2008 |
Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies.
Topics: Adenovirus E3 Proteins; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding, Competitive; Carbohydrates; Cell Line; Conserved Sequence; Cysteine; Epitopes; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis; Mutant Proteins; Mutation; Peptide Mapping; Protein Conformation; Recombinant Proteins | 2008 |
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins.
Topics: Alanine; Combinatorial Chemistry Techniques; Cysteine; Escherichia coli; Humans; Leucine-tRNA Ligase; Methionine; Molecular Structure; Mutation; Protein Conformation; Proteins; RNA, Transfer; Superoxide Dismutase | 2008 |
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Female; Glutamic Acid; Glycine; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Mice; Microinjections; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Piperidines; Plasmids; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Reference Standards; Sequence Homology, Amino Acid; Temperature; Xenopus laevis; Zinc | 2009 |
A preliminary report on the effect of dimeric rhGDF-5 and its monomeric form rhGDF-5C465A on bone healing of rat cranial defects.
Topics: Absorbable Implants; Alanine; Animals; Bone Diseases; Collagen; Cysteine; Disulfides; Drug Carriers; Growth Differentiation Factor 5; Osteogenesis; Parietal Bone; Protein Multimerization; Rats; Rats, Wistar; Recombinant Proteins; Treatment Outcome; Wound Healing | 2009 |
DNA repair and free radicals, new insights into the mechanism of spore photoproduct lyase revealed by single amino acid substitution.
Topics: Alanine; Amino Acids; Bacillus subtilis; Catalysis; Catalytic Domain; Cloning, Molecular; Cysteine; DNA Repair; Free Radicals; Iron-Sulfur Proteins; Models, Chemical; Proteins; Sulfinic Acids; Thymine; Ultraviolet Rays | 2008 |
Reversible intramolecular hydrogen transfer between cysteine thiyl radicals and glycine and alanine in model peptides: absolute rate constants derived from pulse radiolysis and laser flash photolysis.
Topics: Alanine; Cysteine; Glycine; Hydrogen; Kinetics; Peptides; Photochemistry | 2008 |
Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Copper; Cysteine; Humans; Molecular Chaperones; Molecular Sequence Data; Mutation; Protein Multimerization; Protein Structure, Tertiary; Selenocysteine; Spectrum Analysis; Sulfhydryl Compounds; Superoxide Dismutase | 2008 |
Changing the recognition site of a conjugative relaxase by rational design.
Topics: Alanine; Amino Acid Substitution; Base Sequence; Binding Sites; Conjugation, Genetic; Cysteine; DNA Nucleotidyltransferases; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Models, Genetic; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Plasmids; Protein Binding; Protein Engineering; Substrate Specificity; Valine | 2009 |
A disulfide linked model of the complement protein C8gamma complexed with C8alpha indel peptide.
Topics: Alanine; Complement C8; Crystallography, X-Ray; Cysteine; Dimerization; Disulfides; Humans; Models, Chemical; Models, Molecular; Peptides; Protein Conformation | 2009 |
A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Biophysical Phenomena; Conserved Sequence; Cysteine; Dithiothreitol; Ether-A-Go-Go Potassium Channels; Hydrophobic and Hydrophilic Interactions; Ion Channel Gating; Molecular Sequence Data; Mutant Proteins; Mutation; Oxidation-Reduction; Protein Structure, Secondary; Protein Structure, Tertiary; Structure-Activity Relationship; Xenopus laevis | 2008 |
The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity.
Topics: Alanine; Catalytic Domain; Crystallography, X-Ray; Cysteine; Cysteine Synthase; Hydrogen Peroxide; Models, Chemical; Mycobacterium tuberculosis; Oxidative Stress; Protein Conformation; Sulfur | 2009 |
An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen.
Topics: Alanine; Amino Acid Sequence; Animals; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; CHO Cells; Cricetinae; Cricetulus; Cysteine; Electrophysiology; Escherichia coli; Hydrogen-Ion Concentration; Lipid Bilayers; Lysine; Membrane Potentials; Mutation; Phenylalanine; Potassium; Protein Multimerization | 2009 |
Noncooperative Formation of the off-pathway molten globule during folding of the alpha-beta parallel protein apoflavodoxin.
Topics: Alanine; Amino Acid Substitution; Apoproteins; Azotobacter vinelandii; Cysteine; Flavodoxin; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Thermodynamics | 2009 |
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.
Topics: Alanine; Catalysis; Cystathionine gamma-Lyase; Cysteine; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Hyperhomocysteinemia; Kinetics; Mass Spectrometry; Models, Chemical; Recombinant Proteins; Sulfides; Sulfur; Temperature | 2009 |
Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli.
Topics: Alanine; Cysteine; Diamide; Escherichia coli; Methionine; Methyltransferases; Mutation; Oxidation-Reduction; Structure-Activity Relationship | 2009 |
Elucidation of the disulfide bridge pattern of the recombinant human growth and differentiation factor 5 dimer and the interchain Cys/Ala mutant monomer.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Escherichia coli; Growth Differentiation Factor 5; Humans; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Protein Conformation; Protein Multimerization; Recombinant Proteins | 2009 |
Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Membrane; Chlorocebus aethiops; COS Cells; Cysteine; Dimerization; Fluorescence Resonance Energy Transfer; Inhibitory Concentration 50; Membrane Lipids; Microscopy, Fluorescence; Molecular Sequence Data; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Secretin; Transfection | 2009 |
Construction and functional analyses of a comprehensive sigma54 site-directed mutant library using alanine-cysteine mutagenesis.
Topics: Alanine; Cysteine; DNA; DNA-Directed RNA Polymerases; Gene Library; Isomerism; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Protein Structure, Tertiary; RNA Polymerase Sigma 54; Transcription, Genetic | 2009 |
Chemical analysis of late stages of pheomelanogenesis: conversion of dihydrobenzothiazine to a benzothiazole structure.
Topics: Acids; Alanine; Animals; Benzothiazoles; Cysteine; Cysteinyldopa; Dihydroxyphenylalanine; Hair Color; Humans; Hydrolysis; Iodine Compounds; Melanins; Mice; Monophenol Monooxygenase; Oxidation-Reduction; Peroxides; Thiazines | 2009 |
Enantiospecific adsorption of amino acids on hydroxylated quartz (0001).
Topics: Adsorption; Alanine; Amino Acids; Cysteine; Glycine; Hydrogen Bonding; Hydroxylation; Models, Molecular; Molecular Conformation; Quantum Theory; Quartz; Serine; Stereoisomerism | 2009 |
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions.
Topics: Alanine; Chromatography, High Pressure Liquid; Computer Simulation; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Humans; Hydrogen Sulfide; Kinetics; Mass Spectrometry; Models, Biological; Models, Chemical; Molecular Conformation; Serine; Sulfides; Sulfur | 2009 |
Alanine substitutions of noncysteine residues in the cysteine-stabilized alphabeta motif.
Topics: Alanine; alpha-Amylases; Amino Acid Sequence; Amino Acid Substitution; Circular Dichroism; Cysteine; Defensins; Fabaceae; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins; Protein Binding; Protein Denaturation; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Stability; Protein Structure, Secondary; Proteins; Sequence Alignment; Spectrometry, Fluorescence | 2009 |
Aplysia cys-loop glutamate-gated chloride channels reveal convergent evolution of ligand specificity.
Topics: Alanine; Amino Acid Sequence; Animals; Aplysia; Chloride Channels; Cysteine; Evolution, Molecular; Glycine; Ion Channel Gating; Ivermectin; Ligands; Molecular Sequence Data; Phylogeny; Protein Subunits; Receptors, GABA-A; Sequence Alignment; Substrate Specificity | 2009 |
The CDH1-160C>A polymorphism is a risk factor for colorectal cancer.
Topics: Aged; Alanine; Antigens, CD; Cadherins; Case-Control Studies; Colorectal Neoplasms; Cysteine; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; United Kingdom; White People | 2009 |
Through the looking glass, mechanistic insights from enantiomeric human defensins.
Topics: Alanine; alpha-Defensins; Aminobutyrates; Animals; Antigens, Bacterial; Bacterial Toxins; Crystallography, X-Ray; Cysteine; Escherichia coli; Humans; Kinetics; Mice; Microbial Sensitivity Tests; Staphylococcus aureus; Stereoisomerism; Surface Plasmon Resonance | 2009 |
Facile formation of dehydroalanine from S-nitrosocysteines.
Topics: Alanine; Catalysis; Cysteine; Phosphines; S-Nitrosothiols | 2009 |
Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin.
Topics: Alanine; Amino Acid Substitution; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Chlorocebus aethiops; Cofilin 1; COS Cells; Cysteine; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibroblasts; Humans; Hydrogen Peroxide; Mitochondria, Liver; Oxidants; Oxidation-Reduction; Plasmids; Rats; Recombinant Proteins; RNA, Small Interfering; Subcellular Fractions; Taurine; Time Factors; Transfection | 2009 |
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation.
Topics: Alanine; Anticodon; Archaea; Catalysis; Codon; Crystallography, X-Ray; Cysteine; Kinetics; Models, Molecular; Molecular Conformation; Mutation; Protein Conformation; Protein Structure, Tertiary; RNA, Transfer; Temperature | 2009 |
Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Topics: Aged; Alanine; Asian People; Cell Adhesion Molecules; Cysteine; Female; Genetic Predisposition to Disease; Genotype; Glycine; GTPase-Activating Proteins; Humans; Hypertension; Logistic Models; Male; Middle Aged; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Polymorphism, Genetic | 2010 |
Kinetic analysis of cysteine desulfurase CD0387 from Synechocystis sp. PCC 6803: formation of the persulfide intermediate.
Topics: Alanine; Bacterial Proteins; Carbon-Sulfur Lyases; Catalytic Domain; Cysteine; Kinetics; Mutagenesis, Site-Directed; Spectrophotometry; Substrate Specificity; Sulfides; Synechocystis | 2009 |
Desulfurization of cysteine-containing peptides resulting from sample preparation for protein characterization by mass spectrometry.
Topics: Alanine; Cysteine; Disulfides; Mass Spectrometry; Oxidation-Reduction; Peptides; Proteins | 2010 |
Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus.
Topics: Alanine; Biological Transport; Cysteine; Humans; Membrane Transport Proteins; Protein Structure, Secondary; Serine | 2010 |
N-terminal acetylation of cellular proteins creates specific degradation signals.
Topics: Acetylation; Alanine; Amino Acid Sequence; Cysteine; Half-Life; Methionine; Protein Stability; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Substrate Specificity; Ubiquitin-Protein Ligases; Ubiquitination; Valine | 2010 |
Cysteine as a modulator residue in the active site of xenobiotic reductase A: a structural, thermodynamic and kinetic study.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Coumarins; Cysteine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Protein Conformation; Pseudomonas putida; Serine; Substrate Specificity; Thermodynamics; Xenobiotics | 2010 |
Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor A activation.
Topics: Alanine; Amino Acid Substitution; Animals; Bacterial Proteins; Cell Line; Cysteine; Dimerization; DNA-Binding Proteins; Escherichia coli Proteins; Humans; Membrane Proteins; Models, Molecular; Protein Conformation; Protein Stability; Protein Structure, Tertiary; Rats; Receptors, Atrial Natriuretic Factor; Signal Transduction; Transcription Factors | 2010 |
Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes?
Topics: Alanine; Anaerobiosis; Binding Sites; Catalysis; Cysteine; Electron Spin Resonance Spectroscopy; Eukaryota; Glycine; Iron-Sulfur Proteins; Oxidation-Reduction; S-Adenosylmethionine; Serine; Substrate Specificity; Sulfatases | 2010 |
Anatomy of a red copper center: spectroscopic identification and reactivity of the copper centers of Bacillus subtilis Sco and its Cys-to-Ala variants.
Topics: Alanine; Bacillus subtilis; Bacterial Proteins; Copper; Cysteine; Genetic Variation; Ligands; Membrane Proteins; Models, Molecular; Mutagenesis, Site-Directed; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Sulfhydryl Compounds; X-Ray Absorption Spectroscopy | 2010 |
The action of formaldehyde on the cystine disulphide linkage of wool; the conversion of subfraction A of the combined cystine into combined lanthionine and djenkolic acid and subfraction B into combined thiazolidine-4-carboxylic acid.
Topics: Alanine; Animals; Cysteine; Cystine; Formaldehyde; Humans; Sulfides; Thiazolidines; Wool | 1947 |
Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification.
Topics: Acidithiobacillus; Alanine; Amino Acid Substitution; Catalytic Domain; Crystallography, X-Ray; Cysteine; Hydrogen Sulfide; Ligands; Oxidation-Reduction; Oxygen; Protein Structure, Secondary; Quinone Reductases; Sulfides | 2010 |
Reversible hydrogen transfer between cysteine thiyl radical and glycine and alanine in model peptides: covalent H/D exchange, radical-radical reactions, and L- to D-Ala conversion.
Topics: Alanine; Amino Acid Sequence; Cysteine; Deuterium Exchange Measurement; Free Radicals; Gas Chromatography-Mass Spectrometry; Glycine; Hydrogen; Models, Molecular; Peptides; Photolysis; Sulfhydryl Compounds; Ultraviolet Rays | 2010 |
Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Bacillus cereus; Cysteine; Gene Knockout Techniques; Molecular Sequence Data; Multigene Family; Mutation; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Conformation; Serine | 2010 |
Single-molecule dynamics of gating in a neurotransmitter transporter homologue.
Topics: Alanine; Allosteric Regulation; Aquifoliaceae; Bacterial Proteins; Crystallography, X-Ray; Cysteine; Escherichia coli; Fluorescence Resonance Energy Transfer; Leucine; Models, Molecular; Molecular Dynamics Simulation; Plasma Membrane Neurotransmitter Transport Proteins; Protein Conformation; Sodium | 2010 |
The application of an aryl hydrazine linker prevents beta-elimination side products in the SPPS of C-terminal cysteine peptides.
Topics: Alanine; Amino Acid Sequence; Cysteine; Hydrazines; Molecular Sequence Data; Molecular Structure; Peptides | 2010 |
Structural and biochemical characterization of free methionine-R-sulfoxide reductase from Neisseria meningitidis.
Topics: Alanine; Catalysis; Cysteine; Dimerization; Disulfides; Genomics; Kinetics; Methionine Sulfoxide Reductases; Models, Chemical; Mutation; Neisseria meningitidis; Peptides; Protein Binding; Protein Structure, Tertiary; Sulfenic Acids | 2010 |
Molecular dynamics simulations of Zn(2+) coordination in protein binding sites.
Topics: Alanine; Alcohol Dehydrogenase; Amino Acids; Binding Sites; Cysteine; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Proteins; Zinc | 2010 |
Biological hydrogen production by the algal biomass Chlorella vulgaris MSU 01 strain isolated from pond sediment.
Topics: Alanine; Anaerobiosis; Aspartic Acid; Biomass; Bioreactors; Carbon; Chlorella vulgaris; Citric Acid; Culture Media; Cysteine; Fermentation; Geologic Sediments; Glucose; Hydrogen; Hydrogen-Ion Concentration; Mannitol; Pyruvic Acid; Succinic Acid | 2011 |
Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Alkynes; Animals; Aorta, Thoracic; Clone Cells; Cyclic AMP; Cyclic GMP; Cystathionine gamma-Lyase; Cysteine; Endothelial Cells; Glycine; Humans; Hydrogen Sulfide; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; RNA, Small Interfering; Vasodilation | 2010 |
Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum.
Topics: Acylation; Alanine; Animals; CD36 Antigens; Cell Line, Tumor; Cell Membrane; Chlorocebus aethiops; COS Cells; Cysteine; Endoplasmic Reticulum; Flow Cytometry; Golgi Apparatus; Humans; Immunoblotting; Lipoproteins, LDL; Lipoylation; Membrane Microdomains; Microscopy, Fluorescence; Mutation; Protein Processing, Post-Translational; Protein Transport; RNA Processing, Post-Transcriptional | 2010 |
Proliferative and protective effects of SurR9-C84A on differentiated neural cells.
Topics: Alanine; Amino Acid Motifs; Amino Acid Substitution; Animals; Arginine; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Proliferation; Cysteine; Humans; Inhibitor of Apoptosis Proteins; Mice; Microtubules; Mutation; Neurons; Protein Binding; Repressor Proteins; Survivin; Tretinoin | 2010 |
Traceless ligation of cysteine peptides using selective deselenization.
Topics: Alanine; Amino Acid Sequence; Cysteine; Peptides; Phosphines; Selenocysteine | 2010 |
Kinetic analysis of the bisubstrate cysteine desulfurase SufS from Bacillus subtilis.
Topics: Alanine; Bacillus subtilis; Bacterial Proteins; Carbon-Sulfur Lyases; Cysteine; Iron-Sulfur Proteins; Kinetics | 2010 |
Novel oxidative modifications in redox-active cysteine residues.
Topics: Alanine; Amino Acid Sequence; Animals; Catalytic Domain; Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); HEK293 Cells; Humans; Mass Spectrometry; Mice; Mitochondrial Proteins; Molecular Sequence Data; Mutant Proteins; Nucleoside-Diphosphate Kinase; Oxidation-Reduction; Peptides; Peroxiredoxin VI; Protein Processing, Post-Translational; Recombinant Proteins; Serine; Sulfenic Acids; Sulfinic Acids | 2011 |
Chemical form of selenium affects its uptake, transport, and glutathione peroxidase activity in the human intestinal Caco-2 cell model.
Topics: Alanine; Caco-2 Cells; Cysteine; Enzyme Activation; Glutathione Peroxidase; Humans; Organoselenium Compounds; Selenium; Selenocysteine; Sodium Selenite | 2011 |
Why does the inner-helix mutation A413C double the stoichiometry of Kv1.3 channel block by emopamil but not by verapamil?
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Cysteine; Humans; Hydrogen Bonding; Kv1.3 Potassium Channel; Molecular Sequence Data; Mutation; Potassium Channel Blockers; Protein Structure, Secondary; Stereoisomerism; Verapamil | 2011 |
Evidence for the presence of a critical disulfide bond in the mouse EP3γ receptor.
Topics: Alanine; Animals; Cysteine; Disulfides; HEK293 Cells; Humans; Mice; Mutagenesis, Site-Directed; Mutation; Receptors, Prostaglandin E, EP3 Subtype; Transfection | 2011 |
Viral envelope protein folding and membrane hemifusion are enhanced by the conserved loop region of HIV-1 gp41.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cell Fusion; Cell Line, Tumor; Cell Survival; Cysteine; Disulfides; HIV Envelope Protein gp41; HIV-1; Host-Pathogen Interactions; Humans; Jurkat Cells; Kinetics; Membrane Fusion; Molecular Sequence Data; Oxidation-Reduction; Peptides; Protein Conformation; Protein Folding; Time Factors | 2011 |
Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase.
Topics: Alanine; Binding Sites; Catalysis; Catalytic Domain; Chromatography, High Pressure Liquid; Cloning, Molecular; Cysteine; Glutathione; Glutathione Transferase; Humans; Mass Spectrometry; Methionine; Mutagenesis, Site-Directed; Protein Binding; Substrate Specificity | 2011 |
BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility.
Topics: Adult; Aged; Alanine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Case-Control Studies; Cell Line, Tumor; Cysteine; Female; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Genetic Predisposition to Disease; Genotype; Humans; Immunohistochemistry; Logistic Models; Lymphatic Metastasis; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-bcl-2; Risk Assessment; Risk Factors | 2011 |
The role of Cys271 in conformational changes of arginine kinase.
Topics: Alanine; Animals; Arginine Kinase; Catalysis; Chromatography, Gel; Cloning, Molecular; Cysteine; DNA Primers; Fluorescence; Mutagenesis, Site-Directed; Penaeidae; Protein Conformation; Structure-Activity Relationship | 2011 |
Three novel CYP17A1 gene mutations (A82D, R125X, and C442R) found in combined 17α-hydroxylase/17,20-lyase deficiency.
Topics: Adrenal Hyperplasia, Congenital; Adult; Alanine; Amino Acid Substitution; Arginine; Aspartic Acid; Base Sequence; Cells, Cultured; Cysteine; Female; Humans; Mutation, Missense; Steroid 17-alpha-Hydroxylase; Young Adult | 2011 |
A "tag-and-modify" approach to site-selective protein modification.
Topics: Alanine; Alkynes; Azides; Catalysis; Copper; Cysteine; Disulfides; Free Radicals; Glycosylation; Palladium; Protein Prenylation; Proteins; Ruthenium | 2011 |
Application of XANES profiles to X-ray spectromicroscopy for biomedical specimens: Part I. Discrimination of macromolecules with sulfur atoms.
Topics: Alanine; Animals; Cattle; Cysteine; Cystine; Glutathione; Hemoglobins; Histones; Macromolecular Substances; Methionine; Molecular Conformation; Serum Albumin, Bovine; Spectrometry, X-Ray Emission; Sulfides; Sulfur Compounds | 2011 |
Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Alanine; Antitubercular Agents; Catalytic Domain; Cell Wall; Crystallography, X-Ray; Cysteine; Drug Design; Energy Metabolism; Enzyme Inhibitors; Histidine; Molecular Dynamics Simulation; Mycobacterium tuberculosis; Protein Conformation; Protons | 2011 |
Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy.
Topics: Age Factors; Aged; Aged, 80 and over; Alanine; Alleles; Angiotensinogen; Confidence Intervals; Cysteine; DNA Transposable Elements; Female; Gene Deletion; Genetic Predisposition to Disease; Genotype; Humans; Male; Methionine; Middle Aged; Odds Ratio; Optic Neuropathy, Ischemic; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sex Factors; Threonine | 2011 |
Adsorption of amino acids (ALA, CYS, HIS, MET) on zeolites: fourier transform infrared and Raman spectroscopy investigations.
Topics: Adsorption; Alanine; Amino Acids; Cysteine; Histidine; Hydrogen-Ion Concentration; Methionine; Microscopy, Electron, Scanning; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Zeolites | 2011 |
L-cysteine-enhanced renaturation of bioactive soluble tumor necrosis factor ligand family member LIGHT from inclusion bodies in Escherichia coli.
Topics: Alanine; Apoptosis; Biological Assay; Buffers; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanidine; Humans; Inclusion Bodies; Plasmids; Protein Renaturation; Recombinant Proteins; Tumor Necrosis Factor Ligand Superfamily Member 14 | 2011 |
Cross-linking of wheat gluten proteins during production of hard pretzels.
Topics: Alanine; Chromatography, Ion Exchange; Cross-Linking Reagents; Cysteine; Cystine; Food Handling; Food Technology; Glutens; Hot Temperature; Hydrogen-Ion Concentration; Lysine; Lysinoalanine; Maillard Reaction; Reducing Agents; Sodium Dodecyl Sulfate; Sodium Hydroxide; Sulfides; Triticum | 2012 |
Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.
Topics: Adenosine Triphosphate; Alanine; Animals; Calcium; Calcium Signaling; Cell Line, Transformed; Computer Simulation; Cysteine; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Humans; Ion Channel Gating; Membrane Potentials; Models, Molecular; Mutation; Patch-Clamp Techniques; Permeability; Rats; Receptors, Purinergic P2X3; Silver Nitrate; Transfection; Tyrosine | 2011 |
Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine.
Topics: Alanine; Amino Acid Sequence; Cysteine; Deuterium Exchange Measurement; Deuterium Oxide; Free Radicals; Hydrogen; Hydrogen-Ion Concentration; Peptides; Photolysis; Thermodynamics | 2011 |
Interdomain movements in metabotropic glutamate receptor activation.
Topics: Alanine; Allosteric Regulation; Animals; Cysteine; Disulfides; Humans; Models, Molecular; Movement; Mutant Proteins; Mutation; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2011 |
Formation of dehydroalanine from mimosine and cysteine: artifacts in gas chromatography/mass spectrometry based metabolomics.
Topics: Alanine; Artifacts; Cells, Cultured; Cysteine; Gas Chromatography-Mass Spectrometry; Hot Temperature; Humans; Metabolomics; Mimosine; Skin | 2011 |
Using infrared spectroscopy of cyanylated cysteine to map the membrane binding structure and orientation of the hybrid antimicrobial peptide CM15.
Topics: Alanine; Algorithms; Anti-Infective Agents; Antimicrobial Cationic Peptides; Circular Dichroism; Cysteine; Lauric Acids; Lipid Bilayers; Lipid Metabolism; Lipids; Micelles; Phosphatidylcholines; Protein Structure, Secondary; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Thiocyanates | 2011 |
Are thrombophilia more multifactorial than we thought: report of mosaicism for FII G20210A and novel FII T20061C gene variants.
Topics: Alanine; Biomarkers; Cysteine; Female; Genotype; Glycine; Humans; Hypertension, Pulmonary; Middle Aged; Mosaicism; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prothrombin; Pulmonary Embolism; Recurrence; Risk Factors; Threonine; Thrombophilia | 2012 |
Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicans.
Topics: Alanine; Amino Acid Substitution; ATP-Binding Cassette Transporters; Candida albicans; Cross-Linking Reagents; Cysteine; Drug Resistance, Fungal; Fungal Proteins; Membrane Transport Proteins; Mutagenesis, Site-Directed | 2012 |
Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications.
Topics: Alanine; Alkylation; Cysteine; Histones; Humans; Models, Molecular; Protein Conformation; Protein Processing, Post-Translational | 2012 |
Biophysical characterisation of the nucleocapsid protein from a highly pathogenic porcine reproductive and respiratory syndrome virus strain.
Topics: Alanine; Amino Acid Substitution; Animals; Cysteine; Nucleocapsid Proteins; Porcine Reproductive and Respiratory Syndrome; Porcine respiratory and reproductive syndrome virus; RNA, Viral; Swine | 2012 |
Insights into the mechanism of activation of the phosphorylation-independent response regulator NblR. Role of residues Cys69 and Cys96.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Cysteine; Gene Expression Regulation, Bacterial; Light; Oxidation-Reduction; Phosphorylation; Photosynthesis; Phycobilisomes; Protein Conformation; Sequence Alignment; Stress, Physiological; Synechococcus; Transcription Factors | 2012 |
Toxic role of K+ channel oxidation in mammalian brain.
Topics: 2,2'-Dipyridyl; Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Animals, Genetically Modified; Apoptosis; Brain; Caenorhabditis elegans; Cells, Cultured; Cricetinae; Cricetulus; Cysteine; Disease Models, Animal; Disulfides; Electric Stimulation; Embryo, Mammalian; Female; Fluoresceins; Humans; Hydrogen Peroxide; Male; Mass Spectrometry; Membrane Potentials; Mice; Neurons; Oxidants; Oxidation-Reduction; Oxidative Stress; Patch-Clamp Techniques; Peptide Fragments; Presenilin-1; Propanols; Shab Potassium Channels; Transfection | 2012 |
Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations.
Topics: Alanine; Amino Acid Sequence; Carbohydrate Sequence; Cysteine; Erythropoietin; Glycosylation; Models, Chemical; Molecular Sequence Data; Molecular Structure; Oligosaccharides; Peptide Fragments; Protein Stability; Protein Structure, Secondary | 2012 |
Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Biological Transport; Cell Line, Transformed; Cell Membrane; Cysteine; Estradiol; Estrone; HEK293 Cells; Humans; Kinetics; Leukotriene C4; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Structure-Activity Relationship | 2012 |
From EPOthilone to EPO: Aa challenge for natural product synthesis.
Topics: Alanine; Cysteine; Erythropoietin; Peptide Fragments | 2012 |
Functional significance of conserved cysteines in the human organic cation transporter 2.
Topics: 1-Methyl-4-phenylpyridinium; Alanine; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Cricetinae; Cricetulus; Cysteine; Female; Humans; Mutation; Organic Cation Transport Proteins; Organic Cation Transporter 2; Ovary; Phenylalanine; Tetraethylammonium; Transfection | 2012 |
Site-specific chemical protein conjugation using genetically encoded aldehyde tags.
Topics: Alanine; Aldehydes; Animals; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cysteine; Escherichia coli; Glycine; Mass Spectrometry; Oxidoreductases Acting on Sulfur Group Donors; Proteins; Recombinant Proteins; Sulfatases | 2012 |
Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acyl Coenzyme A; Alanine; Alkylation; Amino Acid Motifs; Amino Acid Sequence; Animals; Biocatalysis; Calcium; Cysteine; Ions; Mice; Mutagenesis, Site-Directed; Oxidation-Reduction; Phosphatidylcholines; Protein Structure, Tertiary; Recombinant Proteins | 2012 |
Monitoring structural transitions in IDPs by vibrational spectroscopy of cyanylated cysteine.
Topics: Alanine; Algorithms; Chromatography, Affinity; Circular Dichroism; Cysteine; Escherichia coli; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Binding; Protein Conformation; Protein Folding; Recombinant Fusion Proteins; Spectroscopy, Fourier Transform Infrared; Staining and Labeling; Thiocyanates | 2012 |
Investigations on the photoregulation of chloroplast movement and leaf positioning in Arabidopsis.
Topics: Alanine; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Chloroplasts; Cysteine; Darkness; Gene Expression Regulation, Plant; Light; Phosphoproteins; Phytochrome A; Phytochrome B; Plant Leaves; Plants, Genetically Modified; Protein Serine-Threonine Kinases; Protein Structure, Tertiary | 2013 |
Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.
Topics: Alanine; Animals; Binding Sites; Chloride Channels; Cysteine; Cystic Fibrosis Transmembrane Conductance Regulator; Glycine; Hydrazines; Oocytes; Xenopus laevis | 2012 |
Cyclization of peptides by using selenolanthionine bridges.
Topics: Alanine; Amino Acid Sequence; Cyclization; Cysteine; Organoselenium Compounds; Peptides; Stereoisomerism | 2012 |
A buried ionizable residue destabilizes the native state and the transition state in the folding of monellin.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cysteine; Glutamic Acid; Hydrogen-Ion Concentration; Ions; Kinetics; Plant Proteins; Protein Folding; Protein Refolding; Protein Unfolding; Thermodynamics | 2012 |
Are alanine, cysteine, glycine and valine amino acids the cause of non-immune hydrops fetalis?
Topics: Adult; Alanine; Amniocentesis; Amniotic Fluid; Cysteine; Female; Glycine; Humans; Hydrops Fetalis; Pregnancy; Pregnancy Trimester, Second; Ultrasonography, Prenatal; Valine | 2012 |
The role of amino acids in spina bifida.
Topics: Adult; Alanine; Amino Acids; Amniocentesis; Amniotic Fluid; Cystathionine; Cysteine; Female; Gestational Age; Humans; Phenylalanine; Pregnancy; Pregnancy Trimester, Second; Spinal Dysraphism; Tryptophan; Tyrosine; Ultrasonography, Prenatal | 2012 |
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
Topics: Alanine; Allosteric Regulation; Animals; Binding Sites; Cell Line; CHO Cells; Cricetinae; Cysteine; Heart; Humans; KCNQ1 Potassium Channel; Models, Molecular; Mutagenesis, Site-Directed; Myocardium; Quinidine | 2013 |
Lipidation of the autotransporter NalP of Neisseria meningitidis is required for its function in the release of cell-surface-exposed proteins.
Topics: Alanine; Amino Acid Substitution; Cysteine; Kinetics; Lipid Metabolism; Membrane Transport Proteins; Mutagenesis, Site-Directed; Mutant Proteins; Neisseria meningitidis; Protein Processing, Post-Translational; Serine Endopeptidases | 2013 |
The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
Topics: Alanine; Animals; Cystathionine; Cysteine; Cysteine Dioxygenase; Diet; Electron Transport Complex IV; Enzyme Stability; Female; Glutathione; Hydrogen Sulfide; Kidney; Liver; Lung; Male; Mice; Mice, Knockout; Organ Specificity; Pancreas; Sulfides; Taurine | 2013 |
Importance of cysteine residues in the thyroid hormone transporter MCT8.
Topics: 4-Chloromercuribenzenesulfonate; Alanine; Amino Acid Substitution; Cell Line, Tumor; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Humans; Monocarboxylic Acid Transporters; Mutagenesis, Site-Directed; Point Mutation; Sulfhydryl Reagents; Symporters; Time Factors; Transfection | 2013 |
Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2.
Topics: Alanine; Amino Acid Sequence; Amino Acid Transport System ASC; Animals; Binding Sites; Cysteine; HEK293 Cells; Humans; Membrane Potentials; Minor Histocompatibility Antigens; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Structure, Tertiary; Rats; Serine; Sodium | 2013 |
Transmembrane domain V plays a stabilizing role in the function of human bile acid transporter SLC10A2.
Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Biological Transport; Chlorocebus aethiops; COS Cells; Cysteine; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organic Anion Transporters, Sodium-Dependent; Protein Interaction Domains and Motifs; Protein Stability; Recombinant Proteins; Sodium; Symporters; Taurocholic Acid | 2013 |
Combined effects of polymorphisms of DNA-repair protein genes and metabolic enzyme genes on the risk of cholangiocarcinoma.
Topics: Alanine; Arginine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Cysteine; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Genotype; Glutamine; Glutathione Transferase; Histidine; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Serine; Valine; X-ray Repair Cross Complementing Protein 1 | 2013 |
Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Boron Compounds; Calcium Channels; Cysteine; Disulfides; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Kinetics; Molecular Sequence Data; Point Mutation; Protein Structure, Tertiary | 2013 |
Alanine scanning mutagenesis of hepatitis C virus E2 cysteine residues: Insights into E2 biogenesis and antigenicity.
Topics: Alanine; Amino Acid Substitution; Antibodies, Viral; Cysteine; Hepacivirus; Hepatitis C; Humans; Mutagenesis; Tetraspanin 28; Viral Envelope Proteins | 2014 |
Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation.
Topics: Alanine; Amino Acyl-tRNA Synthetases; Anticodon; Carrier Proteins; Cysteine; Escherichia coli; Escherichia coli Proteins; Protein Biosynthesis; Protein Structure, Tertiary; RNA, Transfer, Amino Acyl; RNA, Transfer, Pro | 2014 |
S-Michael additions to chiral dehydroalanines as an entry to glycosylated cysteines and a sulfa-Tn antigen mimic.
Topics: Alanine; Antigens, Tumor-Associated, Carbohydrate; Carbohydrates; Cysteine; Diamide; Glycosylation; Models, Molecular; Molecular Conformation | 2014 |
Four Cys residues in heterodimeric 2-oxoacid:ferredoxin oxidoreductase are required for CoA-dependent oxidative decarboxylation but not for a non-oxidative decarboxylation.
Topics: Acetyl Coenzyme A; Alanine; Archaeal Proteins; Cysteine; Decarboxylation; Escherichia coli; Free Radicals; Iron; Iron-Sulfur Proteins; Ketone Oxidoreductases; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Multimerization; Recombinant Proteins; Sulfolobus; Sulfur | 2014 |
Synthesis of granulocyte-macrophage colony-stimulating factor as homogeneous glycoforms and early comparisons with yeast cell-derived material.
Topics: Alanine; Amino Acid Sequence; Cysteine; Escherichia coli; Glycosylation; Granulocyte-Macrophage Colony-Stimulating Factor; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Conformation | 2014 |
STIM1 and SLC24A4 Are Critical for Enamel Maturation.
Topics: Alanine; Ameloblasts; Amelogenesis; Animals; Antiporters; Arginine; Calcium Signaling; Child; Child, Preschool; Consanguinity; Cysteine; Cytosine; Dental Enamel Hypoplasia; Female; Genetic Variation; Homozygote; Humans; Membrane Proteins; Mice; Mutation, Missense; Neoplasm Proteins; Pedigree; Stromal Interaction Molecule 1; Thymine; Valine | 2014 |
THI1, a protein involved in the biosynthesis of thiamin in Arabidopsis thaliana: structural analysis of THI1(A140V) mutant.
Topics: Alanine; Arabidopsis; Arabidopsis Proteins; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Gene Expression; Isoenzymes; Kinetics; Mutation; Protein Stability; Protein Unfolding; Recombinant Proteins; Thermodynamics; Thiamine; Thiamine Pyrophosphate; Valine | 2014 |
Effects of pH and lactate on hydrogen sulfide production by oral Veillonella spp.
Topics: Alanine; Ammonia; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Hydrogen Sulfide; Hydrogen-Ion Concentration; Lactic Acid; Serine; Sulfides; Veillonella | 2014 |
A facile synthesis of differently protected cystathionines in aqueous solutions.
Topics: Acetates; Alanine; Cystathionine; Cysteine; Peptides; Sodium Bicarbonate; Solutions; Sulfides; Water | 2014 |
A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
Topics: Alanine; Amino Acid Sequence; Animals; Anoctamin-1; Binding Sites; Calcium; Calmodulin; Chloride Channels; Cysteine; Drosophila; Electrophysiology; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Ions; Mice; Molecular Sequence Data; Mutagenesis; Mutation; Neoplasm Proteins; Oxidation-Reduction; Sequence Homology, Amino Acid; Solvents; Strontium; Xenopus laevis | 2014 |
Identification of a unique radical S-adenosylmethionine methylase likely involved in methanopterin biosynthesis in Methanocaldococcus jannaschii.
Topics: Alanine; Cloning, Molecular; Cysteine; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Methanocaldococcus; Methyltransferases; Molecular Structure; Pterins; Substrate Specificity | 2014 |
Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Aurora Kinase A; Binding Sites; Catalytic Domain; Cysteine; Escherichia coli; Models, Molecular; Molecular Sequence Data; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Structure, Secondary; Sulfhydryl Compounds | 2014 |
The sole cysteine residue (Cys301) of tetrathionate hydrolase from Acidithiobacillus ferrooxidans does not play a role in enzyme activity.
Topics: Acidithiobacillus; Alanine; Amino Acid Sequence; Bacterial Proteins; Cysteine; Enzyme Assays; Gene Expression; Hydrolases; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Sequence Alignment | 2014 |
Vitamin B-6 restriction reduces the production of hydrogen sulfide and its biomarkers by the transsulfuration pathway in cultured human hepatoma cells.
Topics: Alanine; Biomarkers; Carcinoma, Hepatocellular; Cysteine; Hep G2 Cells; Homocysteine; Humans; Hydrogen Sulfide; Linear Models; Liver Neoplasms; Pyridoxal Phosphate; Sulfides; Vitamin B 6; Vitamin B 6 Deficiency | 2014 |
Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.
Topics: Adhesins, Bacterial; Alanine; Aspirin; Bacterial Adhesion; Cells, Cultured; Cyclooxygenase 2; Cysteine; Cysteine Endopeptidases; Dinoprostone; Fibroblasts; Gene Knockout Techniques; Gingipain Cysteine Endopeptidases; Gingiva; Humans; Hydrolases; Immunoassay; Intramolecular Oxidoreductases; Mutation; Porphyromonas gingivalis; Prostaglandin-E Synthases; Protein-Arginine Deiminases; Real-Time Polymerase Chain Reaction; Signal Transduction | 2014 |
Pre-steady-state kinetic and structural analysis of interaction of methionine γ-lyase from Citrobacter freundii with inhibitors.
Topics: Alanine; Bacterial Proteins; Carbon-Sulfur Lyases; Catalytic Domain; Citrobacter freundii; Crystallography, X-Ray; Cycloserine; Cysteine; Enzyme Inhibitors; Escherichia coli; Gene Expression; Glycine; Imines; Kinetics; Models, Chemical; Pyridoxal Phosphate; Recombinant Proteins; Thermodynamics; Valine | 2015 |
Conserved disulfide bond is not essential for the adenosine A2A receptor: Extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cell Membrane; Cysteine; Disulfides; Gene Expression; HEK293 Cells; Humans; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Protein Transport; Receptor, Adenosine A2A; Recombinant Proteins; Sequence Alignment; Structure-Activity Relationship | 2015 |
Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.
Topics: Alanine; Animals; Chlorocebus aethiops; COS Cells; Cysteine; HEK293 Cells; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; Protein Subunits; Rats; Receptor, Metabotropic Glutamate 5; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Transcriptional Activation; Transfection | 2015 |
MTHFR C677T and prothrombin G20210A mutations in a woman from Dalmatia with silent brain infarction. .
Topics: Alanine; Anticoagulants; Biomarkers; Brain Infarction; Croatia; Cysteine; Female; Glycine; Heterozygote; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Pedigree; Prothrombin; Threonine; Thrombophilia; Treatment Outcome | 2014 |
Site-directed mutagenesis around the CuA site of a polyphenol oxidase from Coreopsis grandiflora (cgAUS1).
Topics: Alanine; Binding Sites; Catechol Oxidase; Chalcones; Copper; Coreopsis; Cysteine; Mutagenesis, Site-Directed; Plant Proteins | 2015 |
Impact of eNOS-Dependent Oxidative Stress on Endothelial Function and Neointima Formation.
Topics: Alanine; Animals; Aorta; Cattle; Citrulline; Cysteine; Endothelium, Vascular; HEK293 Cells; Humans; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neointima; Nitric Oxide Synthase Type III; Oxidative Stress; Superoxides; Vasodilation | 2015 |
Tetrahydropyranyl, a nonaromatic acid-labile Cys protecting group for Fmoc peptide chemistry.
Topics: Alanine; Amino Acids; Cysteine; Fluorenes; Molecular Structure; Peptides; Pyrans; Solid-Phase Synthesis Techniques | 2015 |
Deletion of the Proposed Iron Chaperones IscA/SufA Results in Accumulation of a Red Intermediate Cysteine Desulfurase IscS in Escherichia coli.
Topics: Alanine; Carbon-Sulfur Lyases; Carrier Proteins; Cysteine; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Iron; Iron-Sulfur Proteins; Molecular Chaperones; Mutagenesis, Site-Directed; Oxidation-Reduction; Pyridoxal Phosphate; Recombinant Proteins; Sulfides | 2015 |
Comparison of the backbone dynamics of wild-type Hydrogenobacter thermophilus cytochrome c(552) and its b-type variant.
Topics: Alanine; Bacteria; Bacterial Proteins; Cysteine; Cytochrome c Group; Heme; Hydrogen; Models, Molecular; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation | 2015 |
In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine-Serine-Cysteine Transporter 2.
Topics: Alanine; Amino Acid Transport System ASC; Animals; Aspartic Acid; Cysteine; Excitatory Amino Acid Transporter 1; Glutamic Acid; Glutamine; Ion Transport; Male; Minor Histocompatibility Antigens; Pericytes; Rats, Wistar; Retina; Serine | 2015 |
Eukaryotic formylglycine-generating enzyme catalyses a monooxygenase type of reaction.
Topics: Alanine; Animals; Baculoviridae; Biocatalysis; Catalytic Domain; Cysteine; Disulfides; Dithiothreitol; Enzyme Assays; Gene Expression; Glycine; Humans; Kinetics; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Oxygen; Recombinant Proteins; Sf9 Cells; Spodoptera; Sulfatases | 2015 |
Albumin binding and ligand-exchange processes of the Ru(III) anticancer agent NAMI-A and its bis-DMSO analogue determined by ENDOR spectroscopy.
Topics: Alanine; Antineoplastic Agents; Buffers; Cysteine; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Humans; Ligands; Organometallic Compounds; Protein Binding; Ruthenium Compounds; Serum Albumin | 2015 |
Identification of lanthionine and lysinoalanine in heat-treated wheat gliadin and bovine serum albumin using tandem mass spectrometry with higher-energy collisional dissociation.
Topics: Alanine; Animals; Cattle; Chymotrypsin; Cysteine; Cystine; Gliadin; Hot Temperature; Hydrogen-Ion Concentration; Lysine; Lysinoalanine; Proteolysis; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfides; Threonine; Triticum; Trypsin | 2016 |
An unusual highly emissive water-soluble iridium lissamine-alanine complex and its use in a molecular logic gate.
Topics: Alanine; Cysteine; Iridium; Logic; Mercury; Molecular Structure; Organometallic Compounds; Rhodamines; Solubility; Water | 2016 |
Conformational Interconversions of Amino Acid Derivatives.
Topics: Alanine; Amino Acids; Cysteine; Models, Molecular; Molecular Conformation; Quantum Theory; Serine; Thermodynamics | 2016 |
Defining Multiple Characteristic Raman Bands of α-Amino Acids as Biomarkers for Planetary Missions Using a Statistical Method.
Topics: Alanine; Aspartic Acid; Atmosphere; Cysteine; Earth, Planet; Exobiology; Extraterrestrial Environment; Glutamine; Glycine; Humans; Mars; Models, Statistical; Space Simulation; Spacecraft; Spectrum Analysis, Raman | 2016 |
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.
Topics: Alanine; Amino Acid Sequence; Animals; Cell Membrane; Conserved Sequence; Cysteine; Disulfides; Electric Conductivity; Genetic Testing; Glycosylation; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Mutagenesis; Mutant Proteins; Mutation; Nerve Tissue Proteins; Potassium Channels; Potassium Channels, Tandem Pore Domain; Protein Binding; Protein Domains; Protein Multimerization; Protein Subunits; Xenopus | 2016 |
Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic.
Topics: Alanine; Animals; Anti-Bacterial Agents; Bacillus cereus; Bacteriocins; Cysteine; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxidoreductases; Peptides; Protein Sorting Signals; Rabbits; Recombinant Proteins; Sulfides; Vancomycin-Resistant Enterococci | 2016 |
Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.
Topics: Adenosine; Alanine; Amino Acid Substitution; Anticodon; Catalytic Domain; Crystallography, X-Ray; Cysteine; Escherichia coli Proteins; Methylation; Methyltransferases; Nucleic Acid Conformation; Protein Structure, Tertiary; RNA, Bacterial; RNA, Transfer, Glu; S-Adenosylmethionine | 2016 |
Nitrile-synthesizing enzyme: Screening, purification and characterization.
Topics: Alanine; Culture Media; Cyanides; Cysteine; Hydrogen-Ion Concentration; Kinetics; Lyases; Molecular Weight; Nitriles; Pseudomonas; Serine; Serine O-Acetyltransferase; Substrate Specificity; Temperature | 2016 |
Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification.
Topics: Alanine; Amino Acid Transport System A; Amino Acid Transport Systems; Animals; Cysteine; Disulfides; Dithiothreitol; Ethylmaleimide; HEK293 Cells; Humans; Ion Transport; Mutagenesis; Mutation; Polyethylene Glycols; Rats; Sodium; Sulfhydryl Compounds | 2016 |
Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU.
Topics: Alanine; Bacillus subtilis; Bacterial Proteins; Carbon-Sulfur Lyases; Catalytic Domain; Crystallography, X-Ray; Cysteine; Deuterium Exchange Measurement; Frataxin; Iron-Binding Proteins; Iron-Sulfur Proteins; Models, Molecular; Multigene Family; Protein Binding; Protein Conformation; Protein Multimerization; Pyridoxal Phosphate; Sulfides | 2016 |
Selective Gas-Phase Oxidation and Localization of Alkylated Cysteine Residues in Polypeptide Ions via Ion/Ion Chemistry.
Topics: Alanine; Alkylation; Cysteine; Gases; Ions; Mass Spectrometry; Oxidation-Reduction; Peptides; Periodic Acid; Protein Processing, Post-Translational; Safrole | 2016 |
The Myeloablative Drug Busulfan Converts Cysteine to Dehydroalanine and Lanthionine in Redoxins.
Topics: Alanine; Busulfan; Cysteine; Humans; Myeloablative Agonists; Sulfides; Tandem Mass Spectrometry | 2016 |
Impact of charged amino acid substitution in the transmembrane domain of L-alanine exporter, AlaE, of Escherichia coli on the L-alanine export.
Topics: Alanine; Amino Acid Motifs; Amino Acid Substitution; Amino Acid Transport Systems, Neutral; Arginine; Aspartic Acid; Biological Transport; Cysteine; Escherichia coli; Escherichia coli Proteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Protein Domains | 2017 |
Combination of Thiol-Additive-Free Native Chemical Ligation/Desulfurization and Intentional Replacement of Alanine with Cysteine.
Topics: Alanine; Amino Acid Sequence; Benzimidazoles; Corticotropin-Releasing Hormone; Cysteine; Humans; Molecular Sequence Data; Nerve Tissue Proteins; Peptides; Solid-Phase Synthesis Techniques; Sulfhydryl Compounds; Urocortins | 2016 |
A conserved glycine residue in the C-terminal region of human ATG9A is required for its transport from the endoplasmic reticulum to the Golgi apparatus.
Topics: Alanine; Amino Acid Motifs; Autophagy-Related Proteins; Cell Membrane; Cysteine; Endoplasmic Reticulum; Gene Deletion; Glycine; Golgi Apparatus; HeLa Cells; Humans; Membrane Proteins; Microscopy, Fluorescence; Protein Domains; Protein Transport; Vesicular Transport Proteins | 2016 |
Solution structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain of Zoocin A.
Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Bacteriocins; Catalytic Domain; Cloning, Molecular; Cysteine; Endopeptidases; Escherichia coli; Gene Expression; Kinetics; Lysostaphin; Models, Molecular; Mutation; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Streptococcus equi; Substrate Specificity | 2017 |
Biochemical and structural characterization of a novel halotolerant cellulase from soil metagenome.
Topics: Alanine; Bacterial Proteins; Catalysis; Cellulase; Cellulose; Circular Dichroism; Crystallography, X-Ray; Cysteine; Hot Temperature; Hydrogen-Ion Concentration; Industrial Microbiology; Metagenome; Models, Molecular; Molecular Conformation; Mutation; Open Reading Frames; Plasmids; Recombinant Proteins; Salts; Soil; Soil Microbiology; Solubility; Substrate Specificity; Temperature | 2016 |
Novel antiplatelet role for a protein disulfide isomerase-targeted peptide: evidence of covalent binding to the C-terminal CGHC redox motif.
Topics: Alanine; Amino Acid Motifs; Blood Platelets; Catalytic Domain; Cysteine; Disulfides; Humans; Oxidation-Reduction; Peptides; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Procollagen-Proline Dioxygenase; Protein Binding; Protein Disulfide-Isomerases; Protein Domains; Protein Folding | 2017 |
Inhibition of STAT3 by Anticancer Drug Bendamustine.
Topics: Alanine; Antineoplastic Agents, Alkylating; Bendamustine Hydrochloride; Binding Sites; Cell Line, Tumor; Cysteine; Drug Screening Assays, Antitumor; Gene Expression; Humans; Peptides; Phosphotyrosine; Point Mutation; Protein Binding; src Homology Domains; STAT3 Transcription Factor; Structure-Activity Relationship | 2017 |
Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions.
Topics: Alanine; Amino Acid Sequence; Animals; Anti-Infective Agents; Bacteria; Bacterial Load; beta-Defensins; Birds; Cell Line; Chemotaxis; Chickens; Colony Count, Microbial; Cysteine; Dendritic Cells; Disulfides; Drug Combinations; Hydrophobic and Hydrophilic Interactions; Macrophages; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Peptides; Protein Conformation; Serine; Sodium Chloride | 2017 |
Comparative studies of the catalytic mechanisms of two chorismatases: CH-fkbo and CH-Hyg5.
Topics: Alanine; Amino Acid Motifs; Bacterial Proteins; Biocatalysis; Catalytic Domain; Chorismic Acid; Cysteine; Glycine; Hydrolysis; Kinetics; Models, Molecular; Oxo-Acid-Lyases; Protons; Pyruvic Acid; Quantum Theory; Streptomyces; Structure-Activity Relationship; Thermodynamics | 2017 |
Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.
Topics: Alanine; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cysteine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Mutation; Peptides, Cyclic; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship | 2017 |
Amino acid composition of rumen bacteria and protozoa in cattle.
Topics: Alanine; Amino Acids; Animal Feed; Animals; Bacteria; Bacterial Proteins; Cattle; Cysteine; Digestion; Duodenum; Lysine; Methionine; Protozoan Proteins; Rumen | 2017 |
Redox regulation of the yeast voltage-gated Ca
Topics: Alanine; Amino Acid Sequence; Calcium Channels; Conserved Sequence; Cysteine; Cytoplasm; Glutathione; Hydrogen-Ion Concentration; Mutation; Oxidation-Reduction; Oxidative Stress; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thioredoxins | 2017 |
Hotspots of age-related protein degradation: the importance of neighboring residues for the formation of non-disulfide crosslinks derived from cysteine.
Topics: Age Factors; Alanine; beta-Crystallin A Chain; Cysteine; Databases, Protein; Disulfides; Eye Proteins; Humans; Lens, Crystalline; Models, Molecular; Oligopeptides; Proteolysis; Tandem Mass Spectrometry | 2017 |
Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.
Topics: Alanine; Amino Acid Substitution; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Bacterial Proteins; Biological Transport; Copper; Cysteine; Cytosol; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; HEK293 Cells; Humans; Luminescent Proteins; Microscopy, Fluorescence; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Protein Folding; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Fusion Proteins; RNA Interference | 2017 |
Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase.
Topics: Alanine; Animals; Biomarkers; Catalysis; Cystathionine beta-Synthase; Cysteine; Haplorhini; Homocysteine; Hydrogen Sulfide; Kinetics; Mice; Mice, Knockout; Serine; Sulfides; Sulfur | 2018 |
B. subtilis as a Model for Studying the Assembly of Fe-S Clusters in Gram-Positive Bacteria.
Topics: Alanine; Bacillus subtilis; Bacterial Proteins; Biosynthetic Pathways; Carbon-Sulfur Lyases; Cysteine; Iron-Sulfur Proteins; Protein Folding; Sulfides | 2017 |
Simultaneous quantification of arginine, alanine, methionine and cysteine amino acids in supplements using a novel bioelectro-nanosensor based on CdSe quantum dot/modified carbon nanotube hollow fiber pencil graphite electrode via Taguchi method.
Topics: Alanine; Amino Acids; Arginine; Cysteine; Dietary Supplements; Electrochemistry; Electrodes; Graphite; Limit of Detection; Methionine; Nanotubes, Carbon; Quantum Dots; Spectroscopy, Fourier Transform Infrared | 2017 |
Potassium channels modulate the action but not the synthesis of hydrogen sulfide in rat corpus cavernosum.
Topics: Alanine; Animals; Cysteine; Dose-Response Relationship, Drug; Glyburide; Hydrogen Sulfide; Male; Penis; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium | 2017 |
Decoding Selection Bias Imparted by Unpaired Cysteines: a Tug of War Between Expression and Affinity.
Topics: Alanine; Animals; Antibody Affinity; Antibody Specificity; Bacteriophage M13; Cysteine; Enzyme-Linked Immunosorbent Assay; Myocardium; Peptide Library; Peroxidase; Rabbits; Single-Chain Antibodies; Troponin I | 2018 |
Active site alanine preceding catalytic cysteine determines unique substrate specificity in bacterial CoA-acylating prenal dehydrogenase.
Topics: Acyl Coenzyme A; Alanine; Bacterial Proteins; Burkholderiales; Catalytic Domain; Cysteine; Oxidoreductases; Substrate Specificity | 2018 |
Probing the Outstanding Local Hydrophobicity Increases in Peptide Sequences Induced by Incorporation of Trifluoromethylated Amino Acids.
Topics: Alanine; Amino Acid Sequence; Cysteine; Halogenation; Hydrophobic and Hydrophilic Interactions; Methionine; Peptides | 2018 |
The Enzymology of Prochlorosin Biosynthesis.
Topics: Alanine; Alkynes; Aquatic Organisms; Cyanobacteria; Cyclization; Cysteine; Kinetics; Peptides; Prochlorococcus; Protein Engineering; Recombinant Proteins; Substrate Specificity; Sulfides; Zinc | 2018 |
Quantification of thioether-linked glutathione modifications in human lens proteins.
Topics: Adolescent; Alanine; Aminobutyrates; Cataract; Cellular Senescence; Chromatography, Liquid; Crystallins; Cysteine; Glutathione; Humans; Lens, Crystalline; Middle Aged; Protein Processing, Post-Translational; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfides; Threonine; Tissue Donors; Young Adult | 2018 |
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Topics: Alanine; Amides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Bridged Bicyclo Compounds; Carboxylic Acids; Catalytic Domain; Crystallography, X-Ray; Cysteine; Humans; Isoxazoles; Molecular Structure; Protease Inhibitors | 2018 |
Escherichia coli and Pseudomonas aeruginosa lipopolysaccharide O-antigen ligases share similar membrane topology and biochemical properties.
Topics: Alanine; Bacterial Proteins; Carbon-Oxygen Ligases; Cell Membrane; Cysteine; Escherichia coli; Escherichia coli Proteins; Lipid A; Maleimides; Membrane Proteins; O Antigens; Periplasm; Polyethylene Glycols; Pseudomonas aeruginosa | 2018 |
Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Fermentation; Glutamic Acid; Glutamine; Glutathione; Hydrogen-Ion Concentration; Metabolic Networks and Pathways; Metabolome; Methionine; Nitrogen; Streptococcus thermophilus | 2018 |
Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
Topics: Alanine; Amino Acid Substitution; Carrier Proteins; Catalysis; Cysteine; Deubiquitinating Enzymes; Endopeptidases; Humans; Mutation; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Trans-Activators; Ubiquitin; Ubiquitin-Specific Proteases; Ubiquitination | 2018 |
Hemoglobin(βC93A)-Albumin Cluster: Mutation of Cysteine-β93 to Alanine Allows Moderate Reduction of O
Topics: Alanine; Amino Acid Substitution; Cysteine; Hemoglobins, Abnormal; Humans; Oxygen; Phytic Acid; Pichia; Protein Binding; Recombinant Proteins; Serum Albumin, Human | 2019 |
Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.
Topics: Alanine; Amino Acid Substitution; Animals; beta-Globins; Biological Transport; Blood Platelets; Cysteine; Disease Models, Animal; Erythrocytes; Hemoglobins; Humans; Hypoxia; Isolated Heart Preparation; Male; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Myocardial Reperfusion Injury; Nitric Oxide; Platelet Activation; Rats, Sprague-Dawley; Skin; Vasodilation; Ventricular Function, Left; Ventricular Pressure | 2019 |
Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C assembling.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Enterococcus faecalis; Escherichia coli; Gene Expression; Kinetics; Molecular Docking Simulation; Mutagenesis, Site-Directed; Peroxiredoxins; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Subunits; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Vancomycin; Vancomycin Resistance | 2019 |
Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex.
Topics: Alanine; Cysteine; Disulfides; Luminescent Proteins; Models, Molecular; Protein Denaturation; Protein Domains; Protein Stability; Red Fluorescent Protein; Single-Domain Antibodies; Temperature; Thermodynamics | 2019 |
Structural and Kinetic Insight into the Biosynthesis of H
Topics: Alanine; Bacterial Proteins; Cystathionine beta-Synthase; Cysteine; Cysteine Synthase; Fusobacterium nucleatum; Humans; Hydro-Lyases; Hydrogen Sulfide; Kinetics; Multienzyme Complexes; Protein Conformation; Pyridoxal Phosphate; Structure-Activity Relationship; Sulfides; Yeasts | 2019 |
Selective Adhesion and Directional Migration of Endothelial Cells Guided by Cys-Ala-Gly Peptide Density Gradient on Antifouling Polymer Brushes.
Topics: Alanine; Cell Adhesion; Cell Movement; Cell Polarity; Cells, Cultured; Chemotaxis; Coated Materials, Biocompatible; Cysteine; Dose-Response Relationship, Drug; Endothelial Cells; Glycine; Humans; Materials Testing; Myocytes, Smooth Muscle; Oligopeptides; Polymers | 2019 |
Isotopically Labeled Clickable Glutathione to Quantify Protein S-Glutathionylation.
Topics: Alanine; Azides; Click Chemistry; Cysteine; Glutathione; Isotope Labeling; Protein S | 2020 |
Boiling down the cysteine-stabilized LTP fold - loss of structural and immunological integrity of allergenic Art v 3 and Pru p 3 as a consequence of irreversible lanthionine formation.
Topics: Alanine; Amino Acid Sequence; Animals; Antigens, Plant; Artemisia; Carrier Proteins; Cross Reactions; Cysteine; Epitopes; Escherichia coli; Food Hypersensitivity; Humans; Immunoglobulin E; Immunoglobulin G; Mice; Plant Proteins; Pollen; Prunus; Sulfides | 2019 |
Alanine, arginine, cysteine, and proline, but not glutamine, are substrates for, and acute mediators of, the liver-α-cell axis in female mice.
Topics: Alanine; Amino Acids; Animals; Arginine; Blood Glucose; Cysteine; Female; Glucagon; Glucagon-Secreting Cells; Glutamine; In Vitro Techniques; Insulin; Liver; Mice; Proline; Receptors, Glucagon | 2020 |
Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus 3C Proteases; Cysteine; Cysteine Endopeptidases; Molecular Docking Simulation; Ritonavir; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |
Arsenite suppresses the transcriptional activity of EVI1 through the binding to CCHC-type Zn finger domain.
Topics: Alanine; Amino Acid Substitution; Arsenites; Binding Sites; Cell Nucleus; Complex Mixtures; Cysteine; Dithiothreitol; Electrophoretic Mobility Shift Assay; GATA2 Transcription Factor; Gene Expression Regulation; Humans; K562 Cells; MDS1 and EVI1 Complex Locus Protein; Peptides; Protein Binding; Recombinant Proteins; Signal Transduction; Sodium Compounds; Zinc Fingers | 2020 |
Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water.
Topics: Alanine; Catalysis; Cysteine; Kinetics; Nitriles; Origin of Life; Peptides; Serine | 2020 |
Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.
Topics: Alanine; Amino Acid Sequence; Cell Nucleus; Cysteine; Lamin Type A; Membrane Proteins; Membranes; Metalloendopeptidases; Metalloproteases; Prenylation; Yeasts; Zinc | 2020 |
The Two Cysteines of Tau Protein Are Functionally Distinct and Contribute Differentially to Its Pathogenicity
Topics: Aging; Alanine; Amino Acid Substitution; Animals; Animals, Genetically Modified; Behavior, Animal; Cysteine; Drosophila; Epitopes; Female; Humans; Male; Microtubules; Mutation; Phosphorylation; tau Proteins; Tauopathies | 2021 |
Role of a cysteine residue in substrate entry and catalysis in MtHIBADH: Analysis by chemical modifications and site-directed mutagenesis.
Topics: Alanine; Alcohol Oxidoreductases; Bacterial Proteins; Catalysis; Cysteine; Dinitrobenzenes; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; p-Chloromercuribenzoic Acid; Protein Conformation; Recombinant Proteins; Serine; Structure-Activity Relationship; Substrate Specificity | 2021 |
Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid.
Topics: Alanine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cysteine; Models, Molecular; Protein Conformation; Protein Processing, Post-Translational; Proteins; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Thiocyanates | 2021 |
Methods to Investigate the Kinetic Profile of Cysteine Desulfurases.
Topics: Alanine; Carbon-Sulfur Lyases; Cysteine; Iron-Sulfur Proteins; Kinetics; Sulfur | 2021 |
Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides.
Topics: Alanine; Alkylation; Aziridines; Catalysis; Chromatography, Gel; Chromatography, Liquid; Cysteine; Heating; Microwaves; Molecular Structure; Peptides; Sulfides | 2021 |
Characterization of Plasmodium falciparum macrophage migration inhibitory factor homologue and its cysteine deficient mutants.
Topics: Alanine; Cysteine; Deoxyribonucleases; Humans; Macrophage Migration-Inhibitory Factors; Plasmodium falciparum; Recombinant Proteins | 2022 |
Poly(dehydroalanine): Synthesis, Properties, and Functional Diversification of a Fluorescent Polypeptide.
Topics: Alanine; Cysteine; Peptides; Sulfhydryl Compounds | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cysteine; Glutamine; Humans; Minor Histocompatibility Antigens; Pancreas; Pancreatic Neoplasms; Reactive Oxygen Species; Serine | 2022 |
Isolation and characterization of novel antihypertensive bioactive peptides from brassica napus and angiotensin-converting enzyme (ace) inhibition potential.
Topics: Alanine; Angiotensins; Antihypertensive Agents; Arginine; Brassica napus; Cysteine; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Peptides; Peptidyl-Dipeptidase A; Phenylalanine; Proline; Tandem Mass Spectrometry; Threonine; Tyrosine; Valine | 2022 |
Oligomeric state of the aspartate:alanine transporter from Tetragenococcus halophilus.
Topics: Alanine; Antiporters; Aspartic Acid; Cysteine; Enterococcaceae; Glutamates; Membrane Transport Proteins; Succinates | 2022 |
Sequential Heck Cross-Coupling and Hydrothiolation Reactions Taking Place in the Ligand Sphere of a Chiral Dehydroalanine Ni(II) Complex: Asymmetric Route to β-Aryl Substituted Cysteines.
Topics: Alanine; Catalysis; Cysteine; Iodides; Ligands | 2022 |
Rapid, sensitive analysis method for determining the nitrogen stable isotope ratio of total free amino acids in soil.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Histidine; Leucine; Lysine; Nitrogen; Nitrogen Isotopes; Phenylalanine; Serine; Soil; Tryptophan | 2022 |
Nontargeted metabolomic analysis to unravel alleviation mechanisms of carbon nanotubes on inhibition of alfalfa growth under pyrene stress.
Topics: Alanine; Aspartic Acid; Cysteine; Glutamates; Glyoxylates; Medicago sativa; Nanotubes, Carbon; Polycyclic Aromatic Hydrocarbons; Pyrenes; Sand; Soil; Soil Pollutants | 2022 |
Characterization of human cystathionine γ-lyase enzyme activities toward d-amino acids.
Topics: Alanine; Amino Acid Isomerases; Amino Acids; Animals; Cystathionine; Cystathionine gamma-Lyase; Cysteine; Escherichia coli; Homoserine; Humans; Hydro-Lyases; Lyases; Mammals; Racemases and Epimerases; Serine | 2022 |
Role of the Cysteine in R3 Tau Peptide in Copper Binding and Reactivity.
Topics: Alanine; Alzheimer Disease; Copper; Cysteine; Disulfides; Dopamine; Humans; Peptides; Protein Aggregates; tau Proteins | 2022 |
Conformational transition induced in the aspartate:alanine antiporter by L-Ala binding.
Topics: Alanine; Antiporters; Aspartic Acid; Binding Sites; Cysteine; Fluorescent Dyes; Lactic Acid; Liposomes; Maleimides; Protein Conformation | 2022 |
LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis.
Topics: Alanine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine; Gene Expression Regulation, Neoplastic; Glutamates; Glutaminase; Glutamine; Humans; Ketoglutaric Acids; Melanoma; MicroRNAs; Oncogenes; RNA, Long Noncoding; Serine; YAP-Signaling Proteins | 2022 |
Effects of hydrogen peroxide and l-tryptophan on antioxidative potential, apoptosis, and mammalian target of rapamycin signaling in bovine intestinal epithelial cells.
Topics: Alanine; Animals; Antioxidants; Apoptosis; Catalase; Cattle; Cysteine; Epithelial Cells; Hydrogen Peroxide; Large Neutral Amino Acid-Transporter 1; Mammals; Oxidative Stress; Serine; Signal Transduction; Superoxide Dismutase; TOR Serine-Threonine Kinases; Tryptophan | 2022 |
Competitive Formation of 2,3-Butanedione and Pyrazines through Intervention of Added Cysteine during Thermal Processing of Alanine-Xylose Amadori Compounds.
Topics: Alanine; Cysteine; Pyrazines; Xylose | 2022 |
Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4
Topics: Alanine; Amino Acid Transport System ASC; Amino Acids; Animals; CD4-Positive T-Lymphocytes; Cysteine; Glutamine; Interferon-gamma; Mammals; Mice; Minor Histocompatibility Antigens; Proanthocyanidins; Serine; T-Lymphocytes; TOR Serine-Threonine Kinases | 2023 |
Cysteine-Induced pH-Dependent Formation of Thiols and Sulfides or 2-Acetylthiazole and Pyrazines during Thermal Treatment of
Topics: Alanine; Cysteine; Hydrogen-Ion Concentration; Maillard Reaction; Pyrazines; Sulfhydryl Compounds; Sulfides; Xylose | 2023 |
Application of Amino Acids for High-Dosage Measurements with Electron Paramagnetic Resonance Spectroscopy.
Topics: Alanine; Amino Acids; Cysteine; Electron Spin Resonance Spectroscopy; Free Radicals; Proline | 2023 |
lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2.
Topics: Alanine; Carrier Proteins; Cell Line, Tumor; Cysteine; Humans; In Situ Hybridization, Fluorescence; Liver Neoplasms; Membrane Proteins; Membrane Transport Proteins; RNA, Long Noncoding; Serine | 2023 |
The redox-sensing mechanism of Agrobacterium tumefaciens NieR as a thiol-based oxidation sensor for hypochlorite stress.
Topics: Agrobacterium tumefaciens; Alanine; Bacterial Proteins; Cysteine; Disulfides; DNA; Escherichia coli; Hypochlorous Acid; Oxidation-Reduction; Sulfhydryl Compounds | 2023 |
ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus.
Topics: Alanine; Amino Acid Transport System ASC; Cell Differentiation; Cysteine; Early Growth Response Protein 1; Glutamine; Humans; Lichen Planus, Oral; Reactive Oxygen Species | 2023 |
Umami-BERT: An interpretable BERT-based model for umami peptides prediction.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Cysteine; Peptides | 2023 |
Discovery of Nedd4 auto-ubiquitination inhibitors.
Topics: Alanine; Cysteine; Tandem Mass Spectrometry; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2023 |
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste | 1987 |
A green fluorescent chemosensor for amino acids provides a versatile high-throughput screening (HTS) assay for proteases.
Topics: Amino Acids; Copper; Drug Evaluation, Preclinical; Endopeptidases; Fluoresceins; Fluorescence; Kinetics; Ligands; Molecular Probes | 2003 |