alanine has been researched along with amyloid beta-peptides in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Daggett, V; Kirshenbaum, K | 1 |
| Fraser, PE; McLaurin, J | 1 |
| Akiyama, H; Ikeda, K; Kondo, H; McGeer, PL; Mori, H; Nishimura, T; Oda, T; Sahara, N | 1 |
| Antzutkin, ON; Balbach, JJ; Leapman, RD; Reed, J; Rizzo, NW; Tycko, R | 1 |
| Davis, J; Keane, DM; Melchor, JP; Romanov, G; Saporito-Irwin, SM; Van Nostrand, WE; Xu, F | 1 |
| Komano, H; Kurono, Y; Maeda, Y; Nishimura, M; Sai, X; Shiraishi, H; Wang, HQ; Yanagisawa, K | 1 |
| Atack, JR; Best, JD; Ellis, S; Harrison, T; Jay, MT; Lewis, HD; Ma, J; Nadin, A; Otu, F; Pattison, C; Reilly, M; Shearman, MS; Williamson, TL | 1 |
| Shivaprasad, S; Wetzel, R; Williams, AD | 1 |
| Herzig, MC; Jucker, M; Paganetti, P; Staufenbiel, M | 1 |
| Argellati, F; d'Abramo, C; Pizzuti, A; Pronzato, MA; Ricciarelli, R; Zingg, JM | 1 |
| Bérod, A; Le Bars, D; Verdurand, M; Zimmer, L | 1 |
| Aoki, M; Dillner, K; Graff, C; Lilius, L; Näslund, J; Rönnbäck, A; Winblad, B; Zhu, S | 1 |
| Chen, YC; Chen, YR; Huang, HB; Lin, TH; Liu, HT; Lo, CJ; Shiao, MS; Su, CL; Wang, CC | 1 |
| Annes, WF; Ayan-Oshodi, M; de la Peña, A; Friedrich, S; Lowe, SL; Sirois, PJ; Willis, BA; Zhang, W | 1 |
| Belda, O; Edlund, M; Jämsä, A; Lindström, E | 1 |
| Popović, K; Sendula-Jengić, V; Smoljan, I; Svedružić, ZM | 1 |
| Hopkins, CR | 1 |
| Chen, YC; Chen, YR; Ho, LK; Huang, HB; Lin, TH; Liu, HT; Lo, CJ; Shiao, MS; Wang, CC | 1 |
| Bhunia, A; Krishnamoorthy, J; Ramamoorthy, A; Yesuvadian, R | 1 |
| Bowers, MT; Liu, D; Roychaudhuri, R; Teplow, DB; Zheng, X | 1 |
| Fukui, K; Hayakari, R; Imaizumi, T; Matsumiya, T; Tanaka, H; Tanji, K; Tsuruga, K; Yachi, K; Yoshida, H | 1 |
| Andreasson, U; Bateman, RJ; Blennow, K; Bourgeois, P; Dean, RA; Holtzman, DM; Marcil, A; Mawuenyega, KG; May, PC; Nutu, M; Paul, SM; Portelius, E; Siemers, E; Sigurdson, WC; Zetterberg, H | 1 |
2 trial(s) available for alanine and amyloid beta-peptides
| Article | Year |
|---|---|
Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants.
Topics: Aged; Alanine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Azepines; Biological Availability; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Administration Schedule; Female; Food-Drug Interactions; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nootropic Agents; Patient Dropouts; Peptide Fragments; Tablets | 2012 |
Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease.
Topics: Adult; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Azepines; Biomarkers; Cohort Studies; Double-Blind Method; Humans; Male; Middle Aged; Peptide Fragments; Protease Inhibitors; Single-Blind Method; Young Adult | 2012 |
20 other study(ies) available for alanine and amyloid beta-peptides
| Article | Year |
|---|---|
Sequence effects on the conformational properties of the amyloid beta (1-28) peptide: testing a proposed mechanism for the alpha-->beta transition.
Topics: Alanine; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Glutamates; Glutamine; Glycine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Structure-Activity Relationship; Water | 1995 |
Effect of amino-acid substitutions on Alzheimer's amyloid-beta peptide-glycosaminoglycan interactions.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Chondroitin Sulfates; Circular Dichroism; Dermatan Sulfate; Glycosaminoglycans; Heparin; Humans; Hydrogen Bonding; Microscopy, Electron; Molecular Sequence Data; Mutation; Peptide Fragments; Protein Binding; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Static Electricity | 2000 |
Variable deposition of amyloid beta-protein (A beta) with the carboxy-terminus that ends at residue valine40 (A beta 40) in the cerebral cortex of patients with Alzheimer's disease: a double-labeling immunohistochemical study with antibodies specific for
Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Antibody Specificity; Cerebral Cortex; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Peptide Fragments; Staining and Labeling; Threonine; Valine | 1997 |
Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils.
Topics: Alanine; Amino Acid Sequence; Amyloid beta-Peptides; Dimerization; Humans; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Structure, Secondary; Quantum Theory | 2000 |
Localization of a fibrillar amyloid beta-protein binding domain on its precursor.
Topics: Alanine; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Binding Sites; Cell Death; Cells, Cultured; Endothelium, Vascular; Escherichia coli; Exons; Humans; Islet Amyloid Polypeptide; Kinetics; Models, Molecular; Molecular Sequence Data; Muscle, Smooth; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Peptides; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2002 |
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Blotting, Western; Carbamates; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; gamma-Aminobutyric Acid; Gene Expression Regulation; Membrane Glycoproteins; Membrane Proteins; Mice; Peptide Fragments; Presenilin-1; Presenilin-2; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; Radioimmunoassay; Statistics, Nonparametric; Transgenes; Triglycerides | 2004 |
Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-di
Topics: Alanine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Azepines; Brain; Dose-Response Relationship, Drug; Endopeptidases; Female; Humans; Male; Mice; Mice, Transgenic; Peptide Fragments; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 2005 |
Alanine scanning mutagenesis of Abeta(1-40) amyloid fibril stability.
Topics: Alanine; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Models, Molecular; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Protein Conformation; Thermodynamics | 2006 |
BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cerebral Amyloid Angiopathy; Disease Models, Animal; Glycine; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Presenilin-1 | 2007 |
In vitro effect of PPAR-gamma2 Pro12Ala polymorphism on the deposition of Alzheimer's amyloid-beta peptides.
Topics: Alanine; Amyloid beta-Peptides; Animals; Cell Line, Transformed; Cloning, Molecular; Enzyme-Linked Immunosorbent Assay; Humans; Luciferases; Mice; Peptide Fragments; Polymorphism, Genetic; PPAR gamma; Proline; Transfection | 2007 |
Effects of amyloid-β peptides on the serotoninergic 5-HT1A receptors in the rat hippocampus.
Topics: Alanine; Amyloid beta-Peptides; Animals; Autoradiography; Fluorine Radioisotopes; Glial Fibrillary Acidic Protein; Hippocampus; Peptide Fragments; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin; Vesicular Glutamate Transport Protein 1 | 2011 |
Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.
Topics: Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition Disorders; Disease Progression; Enzyme-Linked Immunosorbent Assay; Escape Reaction; Exploratory Behavior; Glycine; Humans; Learning Disabilities; Maze Learning; Mice; Mice, Transgenic; Mutation; Peptide Fragments; Statistics, Nonparametric | 2011 |
Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40.
Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Cell Survival; Humans; Leucine; Mutation; Neurons; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Peptide Fragments; Phenylalanine; Protein Conformation; Rats; Urea | 2011 |
BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Azepines; Benzothiadiazines; Cell Line, Tumor; Cyclic S-Oxides; Humans; Peptide Fragments | 2011 |
Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.
Topics: Alanine; Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Azepines; Biocatalysis; Humans; Kinetics; Models, Biological; Mutation; Peptide Fragments; Presenilin-1; Protein Binding; Substrate Specificity | 2012 |
ACS chemical neuroscience molecule spotlight on semagacestat (LY450139).
Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Azepines; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Molecular Structure; Multicenter Studies as Topic; Neuroprotective Agents; Peptide Fragments; Protein Processing, Post-Translational; Receptors, Notch; Signal Transduction | 2010 |
Effect of alanine replacement of l17 and f19 on the aggregation and neurotoxicity of arctic-type aβ40.
Topics: Alanine; Amino Acid Substitution; Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Humans; Kinetics; Mutation; Neurotoxins; Peptide Fragments; Protein Multimerization; Protein Stability; Protein Structure, Secondary; Reactive Oxygen Species | 2013 |
Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study.
Topics: Alanine; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Azepines; Binding Sites; Humans; Imidazoles; Kinetics; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Piperidines; Protease Inhibitors; Protein Conformation; Protein Multimerization; Sulindac | 2014 |
Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation.
Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Microscopy, Electron, Transmission; Mutation; Peptide Fragments; Protein Structure, Secondary; Threonine; Valine | 2015 |
Rebamipide reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Gene Expression; Humans; Neurons; Peptide Fragments; Quinolones; Sirtuin 1 | 2017 |