Compounds > alanine

alanine and alpha-synuclein

alanine has been researched along with alpha-synuclein in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (6.00)18.2507
2000's29 (58.00)29.6817
2010's17 (34.00)24.3611
2020's1 (2.00)2.80

Authors

AuthorsStudies
Epplen, JT; Graeber, M; Kösel, S; Krüger, R; Kuhn, W; Müller, T; Przuntek, H; Riess, O; Schöls, L; Woitalla, D1
Crowther, RA; Goedert, M; Jakes, R; Spillantini, MG1
Conway, KA; Harper, JD; Lansbury, PT2
Alves da Costa, C; Ancolio, K; Checler, F; Uéda, K1
Conway, KA; Lansbury, PT; Rochet, JC1
Epplen, JT; Krüger, R; Kuhn, W; Leenders, KL; Maguire, RP; Müller, T; Portman, AT; Przuntek, H; Riess, O; Schöls, L; Schröder, U; Sprengelmeyer, R; Veenma, L; Woitalla, D1
Copeland, NG; Dawson, TM; Jenkins, NA; Lee, MK; Mandir, AS; Price, DL; Qui, D; Stirling, W; Xu, X; Xu, Y1
Athanassiadou, A; Ellul, J; Papadimitriou, A; Papapetropoulos, S; Papapetropoulos, T; Paschalis, C1
Cha, CI; Chung, YH; Joo, KM; Kim, MJ1
Du, HN; Hu, HY; Hu, J; Li, HT; Luo, XY; Tang, L; Zhou, JW1
Sidhu, A; Vernier, P; Wersinger, C1
Bussell, R; Eliezer, D1
Darabie, AA; Fraser, PE; Han, K; Jo, E; McLaurin, J; Tandon, A1
Bisceglio, G; Farrer, MJ; Hope, AD; Hulihan, M; Kachergus, J; Lincoln, S; Myhre, R1
Aebischer, P; Bauer, M; Brice, A; Iwatsubo, T; Lo Bianco, C; Sajadi, A; Schneider, BL1
Auburger, G; Cabin, DE; Gispert-Sanchez, S; Murphy, D; Myers, RR; Nussbaum, RL1
Axelsen, PH; Englander, SW; Giasson, BI; Graves, CL; Greenbaum, EA; Lupoli, MA; Lynch, DR; Mishizen-Eberz, AJ1
Frasier, M; Haas, C; Kahle, P; Lee, JM; Magnuson, D; McCarthy, L; Walzer, M; Wolozin, B1
Butterfield, DA; Calabrese, V; Frasier, M; Poon, HF; Shreve, N; Wolozin, B1
Cabodevilla, F; Catena, S; Cuadrado, M; Dalfó, E; Ferrer, I; Gil-Bea, FJ; Gómez-Isla, T; Nieto, M; Ramírez, MJ; Ribé, E; Sánchez, B; Sesma, T1
Bax, A; Ulmer, TS1
Copeland, NG; Jenkins, NA; Lee, MK; Martin, LJ; Pan, Y; Price, AC; Price, DL; Sterling, W1
Athanassiadou, A; Chung, EJ; Davanos, N; Ki, CS; Kim, JY; Lee, WY; Stavrou, EF1
Arai, T; Goedert, M; Hasegawa, M; Hisanaga, S; Ishii, A; Iwatsubo, T; Mann, D; Nonaka, T; Saito, T; Taniguchi, S1
Lee, D; Park, SS; Schulz, EM1
Barry, CH; Fink, AL; Ulrih, NP1
Emmanouilidou, E; Stefanis, L; Vekrellis, K1
Gureviciene, I; Gurevicius, K; Tanila, H1
Sotiriou, E; Stefanis, L; Vassilatis, DK; Vila, M1
Adame, A; Crews, L; Dallapiccola, B; Marongiu, R; Masliah, E; Patrick, C; Spencer, B; Trejo, M; Valente, EM1
Aigner, R; Burgmayer, R; Couillard-Despres, S; Kandasamy, M; Klucken, J; Marxreiter, F; Nuber, S; Riess, O; Winkler, J; Winner, B1
Fan, Z; Feany, MB; Hyman, BT; McFarland, NR; McLean, PJ; Schwarzschild, MA; Xu, K1
Giasson, BI; Mazzulli, JR; Waxman, EA1
Bax, A; Bodner, CR; Dobson, CM; Maltsev, AS1
Graham, DR; Sidhu, A1
Bornemann, A; Deller, T; Den Dunnen, WF; Dickson, D; Gai, WP; Gierga, K; Krüger, R; Nuber, S; Petrasch-Parwez, E; Rami, A; Riess, O; Rüb, U; Schöls, L; Seidel, K; Wszolek, Z1
Gerhardt, E; Kermer, P; Outeiro, TF; Szego, ÉM1
Chen, Y; Ding, ZT; Jiang, YP; Lan, DM; Liu, FT; Ren, HM; Wang, J; Wu, JJ; Yue, ZY; Zhao, J1
Aloglu, AK; Coskuner, O; Dunn, A; Sakallioglu, IT; Wise-Scira, O1
Esmer, H; Ettle, B; Klucken, J; Kragh, CL; Marxreiter, F; Masliah, E; May, VE; Nuber, S; Patrick, C; Riess, O; Winkler, J; Winner, B1
Harvey, BK; Maguire-Zeiss, KA; Männistö, PT; Myöhänen, TT; Richie, CT; Savolainen, MH1
Fujinaga, M; Furutsuka, K; Hashimoto, H; Hatori, A; Kawamura, K; Kumata, K; Nengaki, N; Shimoda, Y; Shiomi, S; Takei, M; Wakizaka, H; Xie, L; Yamasaki, T; Yui, J; Zhang, MR1
Boddeke, HW; Copray, JC; Ferrari, MF; Melo, TQ; van Zomeren, KC1
Dai, L; Kuang, S; Li, J; Rao, Z; Tang, X; Yang, L; Zhong, H; Zhong, Z1
Brotchie, JM; Chiu, WH; Decher, N; Geibl, FF; Henrich, MT; Koprich, JB; Lee, B; Matschke, LA; Oertel, WH; Timmermann, L1
Beratis, I; Fragkiadaki, S; Kontaxopoulou, D; Koros, C; Marek, K; Papadimitriou, D; Papageorgiou, SG; Papagiannakis, N; Prentakis, A; Seibyl, J; Simitsi, A; Stamelou, M; Stefanis, L; Trapali, XG1
Krishnamurthy, S; Mishra, A1
Julku, UH; Kilpeläinen, T; Myöhänen, TT; Svarcbahs, R1
Mason, JM; Meade, RM; Watt, KJC; Williams, RJ1

Other Studies

50 other study(ies) available for alanine and alpha-synuclein

ArticleYear
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
    Nature genetics, 1998, Volume: 18, Issue:2

    Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Base Sequence; Female; Humans; Male; Nerve Tissue Proteins; Parkinson Disease; Pedigree; Point Mutation; Polymorphism, Single-Stranded Conformational; Proline; Synucleins

1998
Synthetic filaments assembled from C-terminally truncated alpha-synuclein.
    FEBS letters, 1998, Oct-09, Volume: 436, Issue:3

    Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Cloning, Molecular; Humans; Microscopy, Electron; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Open Reading Frames; Phosphoproteins; Point Mutation; Proline; Recombinant Proteins; Sequence Deletion; Synucleins; Threonine

1998
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.
    Nature medicine, 1998, Volume: 4, Issue:11

    Topics: Age of Onset; Alanine; alpha-Synuclein; Amino Acid Substitution; Circular Dichroism; Humans; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Electron; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphoproteins; Point Mutation; Recombinant Proteins; Substantia Nigra; Synucleins; Threonine

1998
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
    Biochemistry, 2000, Mar-14, Volume: 39, Issue:10

    Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine

2000
Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells.
    Neuroscience letters, 2000, May-12, Volume: 285, Issue:2

    Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Cell Line; Cysteine Endopeptidases; Humans; Mice; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Synucleins; Threonine; Transfection

2000
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein.
    Biochemistry, 2000, Sep-05, Volume: 39, Issue:35

    Topics: Alanine; alpha-Synuclein; Amyloid; Animals; Chromatography, Gel; Humans; Mice; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Protein Conformation; Protein Folding; Protein Precursors; Spectroscopy, Fourier Transform Infrared; Synucleins; Threonine

2000
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.
    Neurology, 2001, May-22, Volume: 56, Issue:10

    Topics: Aged; Alanine; alpha-Synuclein; Amino Acid Sequence; Apolipoproteins E; Brain; DNA Mutational Analysis; Female; Genotype; Germany; Humans; Male; Middle Aged; Mutation; Nerve Tissue Proteins; Neuropsychological Tests; Parkinsonian Disorders; Pedigree; Proline; Synucleins; Thiolester Hydrolases; Tomography, Emission-Computed; Ubiquitin Thiolesterase

2001
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Jun-25, Volume: 99, Issue:13

    Topics: Alanine; alpha-Synuclein; Animals; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; Synucleins; Threonine

2002
Clinical characteristics of the alpha-synuclein mutation (G209A)-associated Parkinson's disease in comparison with other forms of familial Parkinson's disease in Greece.
    European journal of neurology, 2003, Volume: 10, Issue:3

    Topics: Age of Onset; Aged; Aged, 80 and over; Alanine; alpha-Synuclein; DNA Mutational Analysis; Family Health; Female; Glycine; Greece; Humans; Male; Middle Aged; Mutation; Nerve Tissue Proteins; Parkinson Disease; Pedigree; Phenotype; Psychiatric Status Rating Scales; Synucleins

2003
Immunohistochemical study on the distribution of alpha-synuclein in the central nervous system of transgenic mice expressing a human Cu/Zn superoxide dismutase mutation.
    Neuroscience letters, 2003, May-22, Volume: 342, Issue:3

    Topics: Alanine; alpha-Synuclein; Animals; Central Nervous System; Disease Models, Animal; Glycine; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Rats; Superoxide Dismutase; Synucleins; Tissue Distribution

2003
A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.
    Biochemistry, 2003, Jul-29, Volume: 42, Issue:29

    Topics: Alanine; alpha-Synuclein; Amino Acid Motifs; Benzothiazoles; Circular Dichroism; Escherichia coli; Glycine; Humans; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Peptides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Synucleins; Thiazoles; Time Factors; Valine

2003
Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant.
    Biochemistry, 2004, Feb-10, Volume: 43, Issue:5

    Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Biotinylation; Cell Death; Cell Line; Cell Line, Tumor; Cells, Cultured; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Proline; Protein Transport; Rats; Synucleins; Transfection; Trypsin

2004
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein.
    Biochemistry, 2004, Apr-27, Volume: 43, Issue:16

    Topics: Alanine; alpha-Synuclein; Humans; Lipid Metabolism; Liposomes; Micelles; Mutation, Missense; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Phosphatidic Acids; Phosphatidylcholines; Proline; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Threonine

2004
alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis.
    European journal of biochemistry, 2004, Volume: 271, Issue:15

    Topics: Alanine; alpha-Synuclein; Animals; Circular Dichroism; Dimerization; Fatty Acids; Humans; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Protein Binding; Protein Structure, Quaternary; Rats; Spectrometry, Fluorescence; Surface Properties; Synaptic Membranes; Synaptosomes; Synucleins; Tyrosine

2004
Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease.
    Neuroscience letters, 2004, Aug-26, Volume: 367, Issue:1

    Topics: Adult; Age Factors; Alanine; alpha-Synuclein; DNA Mutational Analysis; Exons; Family Health; Female; Humans; Male; Middle Aged; Mutation; Nerve Tissue Proteins; Parkinsonian Disorders; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synucleins; Threonine

2004
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Dec-14, Volume: 101, Issue:50

    Topics: Alanine; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopamine; Female; Gene Expression; Genetic Therapy; Genetic Vectors; Lentivirus; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphorylation; Rats; Rats, Wistar; Synucleins; Ubiquitin-Protein Ligases

2004
Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background.
    Neurobiology of aging, 2005, Volume: 26, Issue:1

    Topics: Age Factors; Alanine; alpha-Synuclein; Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Motor Activity; Mutation; Nerve Tissue Proteins; Parkinson Disease; Phenylenediamines; RNA; Sciatic Nerve; Spinal Cord; Synucleins; Threonine; Wallerian Degeneration

2005
The E46K mutation in alpha-synuclein increases amyloid fibril formation.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Blotting, Western; Calpain; Chromatography, Gel; Circular Dichroism; DNA, Complementary; Glutamic Acid; Humans; Kinetics; Lysine; Microscopy, Electron; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Protein Conformation; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Time Factors

2005
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
    Experimental neurology, 2005, Volume: 192, Issue:2

    Topics: Age Factors; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Movement Disorders; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphorylation; Proline; Synucleins; tau Proteins

2005
Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.
    Neurobiology of disease, 2005, Volume: 18, Issue:3

    Topics: Alanine; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Energy Metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Proline; Synucleins

2005
Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice.
    Neurobiology of aging, 2006, Volume: 27, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; Alanine; alpha-Synuclein; Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Insecticides; Mice; Mice, Transgenic; Neurons; Neurotoxins; Proline; Rotenone; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase

2006
Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Humans; Kinetics; Magnetic Resonance Spectroscopy; Micelles; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutation; Parkinson Disease; Point Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Sodium Dodecyl Sulfate; Valine

2005
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-04, Volume: 26, Issue:1

    Topics: Alanine; alpha-Synuclein; Animals; Brain Stem; Cell Death; DNA Damage; Humans; Mice; Mice, Transgenic; Mitochondria; Mutation; Neocortex; Nerve Degeneration; Parkinson Disease; Threonine

2006
The Ala53Thr mutation in the alpha-synuclein gene in a Korean family with Parkinson disease.
    Clinical genetics, 2007, Volume: 71, Issue:5

    Topics: Adult; Age of Onset; Alanine; alpha-Synuclein; Amino Acid Substitution; Family; Haplotypes; Humans; Korea; Male; Mutation; Parkinson Disease; Pedigree; Threonine

2007
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
    FEBS letters, 2007, Oct-02, Volume: 581, Issue:24

    Topics: Alanine; alpha-Synuclein; Animals; Brain; Casein Kinase II; Epitopes; Heparin; Humans; Mutation; Neurodegenerative Diseases; Phosphoserine; Rats; Tissue Culture Techniques

2007
Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.
    The European journal of neuroscience, 2007, Volume: 26, Issue:11

    Topics: Alanine; alpha-Methyltyrosine; alpha-Synuclein; Animals; Animals, Genetically Modified; Cells, Cultured; Dopamine; Drosophila; Embryo, Nonmammalian; Enzyme Inhibitors; Glutathione; Green Fluorescent Proteins; Homeostasis; Humans; Indoles; Mutation; Nerve Degeneration; Proline; Receptors, Dopamine D1; Time Factors; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins

2007
Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties.
    Biochimica et biophysica acta, 2008, Volume: 1782, Issue:10

    Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Amyloid; Circular Dichroism; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Mutation, Missense; Parkinson Disease; Protein Folding; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Tyrosine

2008
Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome.
    Neurobiology of aging, 2010, Volume: 31, Issue:6

    Topics: Alanine; alpha-Synuclein; Ammonium Chloride; Animals; Benzoquinones; Cerebral Cortex; Chromatography, Gel; Coloring Agents; Congo Red; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Humans; Immunoprecipitation; Lactams, Macrocyclic; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; PC12 Cells; Proteasome Endopeptidase Complex; Protein Folding; Rats; Transfection; Tyrosine

2010
Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus.
    Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:1

    Topics: Aging; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Dentate Gyrus; Electric Stimulation; Escape Reaction; Excitatory Postsynaptic Potentials; Humans; Locomotion; Mice; Mice, Transgenic; Mutation; Neuronal Plasticity; Perforant Pathway; Proline; Reaction Time; Synapses; Time Factors

2009
Selective noradrenergic vulnerability in α-synuclein transgenic mice.
    Neurobiology of aging, 2010, Volume: 31, Issue:12

    Topics: Alanine; alpha-Synuclein; Animals; Disease Models, Animal; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Norepinephrine; Parkinson Disease; Threonine

2010
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.
    Journal of neurochemistry, 2009, Volume: 108, Issue:6

    Topics: Adenosine Triphosphate; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Calcium; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Flufenamic Acid; Gene Expression Regulation; Green Fluorescent Proteins; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mitochondria; Mutation; Neuroblastoma; Neurons; Protein Kinases; Rats; Threonine; Transfection; Tryptophan

2009
Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.
    The European journal of neuroscience, 2009, Volume: 29, Issue:5

    Topics: Alanine; alpha-Synuclein; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Proliferation; Doublecortin Domain Proteins; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mutation; Neurogenesis; Neurons; Neuropeptides; Olfactory Bulb; Proliferating Cell Nuclear Antigen; Proline

2009
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
    Journal of neuropathology and experimental neurology, 2009, Volume: 68, Issue:5

    Topics: Alanine; alpha-Synuclein; Animals; Aspartic Acid; Basal Ganglia; Cell Count; Dependovirus; Disease Models, Animal; Dopamine; Green Fluorescent Proteins; Humans; Mutation; Nerve Tissue Proteins; Parkinson Disease; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; Substantia Nigra; Tyrosine 3-Monooxygenase

2009
Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization.
    Biochemistry, 2009, Oct-13, Volume: 48, Issue:40

    Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Amyloid; Humans; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Transmission; Microscopy, Immunoelectron; Mutagenesis, Site-Directed; Peptide Fragments; Polymers; Protein Folding; Valine

2009
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.
    Biochemistry, 2010, Feb-09, Volume: 49, Issue:5

    Topics: Alanine; alpha-Synuclein; Genetic Variation; Glutamic Acid; Humans; Lysine; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Parkinson Disease; Peptide Fragments; Phospholipids; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Solutions; Threonine

2010
Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior.
    Journal of neuroscience research, 2010, Volume: 88, Issue:8

    Topics: Age Factors; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Anxiety; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Gene Expression Regulation; Humans; Hyperkinesis; Maze Learning; Mice; Mice, Transgenic; Motor Activity; Mutation; Norepinephrine; Serotonin Plasma Membrane Transport Proteins; Tyrosine

2010
First appraisal of brain pathology owing to A30P mutant alpha-synuclein.
    Annals of neurology, 2010, Volume: 67, Issue:5

    Topics: Aged; Alanine; alpha-Synuclein; Brain; Brain Diseases; Family Health; Glial Fibrillary Acidic Protein; Humans; Inclusion Bodies; Male; Mutation; Proline

2010
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.
    Journal of the neurological sciences, 2011, Nov-15, Volume: 310, Issue:1-2

    Topics: Acetylcholinesterase; Alanine; alpha-Synuclein; Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Dopamine; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; MPTP Poisoning; Mutation; Neurons; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor, trkB; Time Factors

2011
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.
    Neurochemical research, 2012, Volume: 37, Issue:9

    Topics: Adenine; Alanine; alpha-Synuclein; Animals; Autophagy; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Lysosomes; Microscopy, Electron, Transmission; PC12 Cells; Phagosomes; Phosphoinositide-3 Kinase Inhibitors; Point Mutation; Proteasome Inhibitors; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles; Threonine; Transduction, Genetic; Trehalose; Up-Regulation

2012
Structures and free energy landscapes of the wild-type and A30P mutant-type α-synuclein proteins with dynamics.
    ACS chemical neuroscience, 2013, Mar-20, Volume: 4, Issue:3

    Topics: Alanine; alpha-Synuclein; Energy Metabolism; Humans; Molecular Dynamics Simulation; Mutant Proteins; Mutation, Missense; Proline; Protein Structure, Secondary; Protein Structure, Tertiary

2013
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.
    Neurobiology of disease, 2013, Volume: 59

    Topics: Alanine; alpha-Synuclein; Animals; Anxiety; Avoidance Learning; Cell Count; Disease Models, Animal; Doublecortin Domain Proteins; Doxycycline; Gene Expression Regulation; Hippocampus; Humans; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurogenesis; Neuroglia; Neuropeptides; Olfactory Bulb; Proline

2013
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.
    Neurobiology of disease, 2014, Volume: 68

    Topics: Alanine; alpha-Synuclein; Animals; Autophagy; Brain; Brain Diseases; Cell Line, Transformed; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Proline; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Time Factors

2014
Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Jan-13, Volume: 36, Issue:2

    Topics: Alanine; alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Agents; Exploratory Behavior; Female; Humans; Motor Activity; Oximes; Parkinson Disease; Protein Binding; Pyridines; Radioisotopes; Radionuclide Imaging; Rats; Rats, Transgenic; Receptors, Metabotropic Glutamate; Threonine; Time Factors

2016
Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease.
    Experimental brain research, 2017, Volume: 235, Issue:3

    Topics: Alanine; alpha-Synuclein; Cell Differentiation; Cell Line, Tumor; Gene Expression Regulation; Humans; Kymography; Luminescent Proteins; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Neuroblastoma; Oligopeptides; Reactive Oxygen Species; RNA, Messenger; Threonine; Transfection

2017
Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson's Disease.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2018, Volume: 45, Issue:2

    Topics: Alanine; alpha-Synuclein; Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Ginkgo biloba; Glutathione; Glutathione Peroxidase; Locomotion; Malondialdehyde; Mice; Mice, Transgenic; Muscle Strength; Mutation; Parkinson Disease; Plant Extracts; Superoxide Dismutase; Swimming; Threonine

2018
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.
    Acta neuropathologica communications, 2018, 05-10, Volume: 6, Issue:1

    Topics: Alanine; alpha-Synuclein; Animals; Calcium-Binding Proteins; Disease Models, Animal; Endopeptidase K; Humans; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Mutation; Nerve Tissue Proteins; Neuroglia; Neurons; Parkinson Disease; Protein Aggregates; Protein Transport; Threonine; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase

2018
123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2018, Volume: 33, Issue:11

    Topics: Adult; Alanine; alpha-Synuclein; Cognition Disorders; Cohort Studies; Corpus Striatum; Dopamine; Female; Functional Laterality; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Threonine; Tomography, Emission-Computed, Single-Photon; Tropanes

2018
Rebamipide Mitigates Impairments in Mitochondrial Function and Bioenergetics with α-Synuclein Pathology in 6-OHDA-Induced Hemiparkinson's Model in Rats.
    Neurotoxicity research, 2019, Volume: 35, Issue:3

    Topics: Administration, Oral; Alanine; alpha-Synuclein; Animals; Antioxidants; Antiparkinson Agents; Apoptosis; Dose-Response Relationship, Drug; Energy Metabolism; Functional Laterality; Male; Mitochondria; Motor Activity; Neuroprotective Agents; Oxidative Stress; Parkinsonian Disorders; Quinolones; Random Allocation; Rats; Substantia Nigra

2019
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
    Scientific reports, 2019, 11-22, Volume: 9, Issue:1

    Topics: Aging; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Humans; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Parkinson Disease; Proline; Threonine

2019
A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding.
    Journal of molecular biology, 2021, 12-03, Volume: 433, Issue:24

    Topics: Alanine; alpha-Synuclein; Antiparkinson Agents; Cryoelectron Microscopy; Cytoplasmic Vesicles; Dopaminergic Neurons; Humans; Lipids; Parkinson Disease; Peptide Library; Peptidomimetics; Point Mutation; Protein Aggregates; Protein Folding

2021