alanine has been researched along with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.38) | 18.7374 |
| 1990's | 22 (52.38) | 18.2507 |
| 2000's | 15 (35.71) | 29.6817 |
| 2010's | 4 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC | 1 |
| Gordon, FJ; Pawloski-Dahm, C | 1 |
| Bowie, D; Smart, TG | 2 |
| Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
| Ross, SM; Roy, DN; Spencer, PS | 1 |
| Bernardi, G; Bonci, A; Calabresi, P; Mercuri, NB; Stratta, F | 1 |
| Bregnedal, P; Brehm, L; Bøgesø, KP; Ebert, B; Frederiksen, K; Hansen, JJ; Krogsgaard-Larsen, P; Lenz, S | 1 |
| Jane, DE; Mayer, ML; Watkins, JC; Wong, LA | 1 |
| Lücke, T; Neugebauer, V; Schaible, HG | 1 |
| Ebert, B; Krogsgaard-Larsen, P; Lenz, SM; Lund, TM; Madsen, U | 1 |
| Beaver, KM; Hawkins, LM; Jane, DE; Roberts, PJ; Sunter, DC; Taylor, PM | 1 |
| Honoré, T; Sheardown, MJ; Suzdak, PD | 1 |
| Mayer, ML; Wong, LA | 1 |
| Bräuner-Osborne, H; Ebert, B; Krogsgaard-Larsen, P; Nakanishi, S; Sekiyama, N; Skjaerbaek, N; Sløk, FA | 1 |
| Fleischer-Lambropoulos, E; Geladopoulos, T; Kazazoglou, T; Kentroti, S; Stefanis, C; Vernadakis, A | 1 |
| Beart, PM; Ganakas, AM; Lawrence, AJ; Lunn, ML; Mercer, LD | 1 |
| Beart, PM; Cheung, NS; Larm, JA | 1 |
| Espitia, SA; Hawkinson, JE | 1 |
| Bonham, AC; Chen, CY; Liu, Z | 1 |
| Banno, T; Kohno, K | 1 |
| Henley, JM; Olivera, S; Rodriguez-Ithurralde, D | 1 |
| Ashworth-Preece, MA; Chen, F; Jarrott, B; Lawrence, AJ | 1 |
| Arai, A; Kessler, M; Rogers, G | 1 |
| Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F | 1 |
| Clippe, A; Gressens, P; Knoops, B; Plaisant, F; Vander Stricht, D | 1 |
| Gouaux, E; Jin, R | 1 |
| Alt, AJ; Bleakman, D; Bortolotto, ZA; Buelens, FP; Clarke, VR; Collingridge, GL; Dolman, NP; Jane, DE; Kelland, EE; More, JC; Nistico, R; Ogden, AM; Pilato, F; Troop, HM | 1 |
| Begtrup, M; Bräuner-Osborne, H; Calí, P; Clausen, RP; Egebjerg, J; Greenwood, JR; Hansen, KB; Nielsen, B | 1 |
| Ayalon, G; Elgavish, S; Segev, E; Stern-Bach, Y | 1 |
| Brask, J; Brodin, L; Chauhan, A; Chaves-Olarte, E; Kjaerulff, O; Löw, P; Owe-Larsson, B; Thelestam, M | 1 |
| Arai, AC; Kessler, M | 1 |
| Dolman, NP; Ghosal, A; Jane, DE; Mayer, ML | 1 |
| Alt, A; Bleakman, D; Collingridge, GL; Dolman, NP; Jane, DE; Knauss, JL; More, JC; Troop, HM | 1 |
| Jayaraman, V; Mankiewicz, KA; Rambhadran, A; Wathen, L | 1 |
| Hammond, RS; Hoffman, DA; Lin, L; Sidorov, MS; Wikenheiser, AM | 1 |
| Frerking, M; Wondolowski, J | 1 |
| Champeil, E; Proni, G; Sapse, D | 1 |
| Lash-Van Wyhe, LL; Pentikäinen, OT; Postila, PA; Sakai, R; Sasaki, M; Swanson, GT; Tsubone, K | 1 |
| Finn, R; Kovács, AD; Pearce, DA | 1 |
| Kumar, J; Mayer, ML; Schuck, P | 1 |
| Chang, YC; Chen, EC; Chung, HW; Fang, W; Hsu, WL; Lee, YT; Wu, CY; Wu, HI | 1 |
42 other study(ies) available for alanine and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
| Article | Year |
|---|---|
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil | 1992 |
Evidence for a kynurenate-insensitive glutamate receptor in nucleus tractus solitarii.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Blood Pressure; Cycloleucine; Electric Stimulation; Female; Heart Rate; Ibotenic Acid; Kynurenic Acid; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Interaction of 5-bromowillardiine with non-NMDA receptors expressed in Xenopus laevis oocytes injected with chick brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chickens; Female; Ibotenic Acid; Injections; Kainic Acid; Membrane Potentials; Neuromuscular Depolarizing Agents; Oocytes; Quisqualic Acid; Receptors, Dopamine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1991 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
Beta-N-oxalylamino-L-alanine action on glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Piperazines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Membranes; Thiocyanates | 1989 |
Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dopamine; Electrophysiology; Female; Glycine; Male; Neurons; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Tetrodotoxin | 1993 |
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Crystallography, X-Ray; Dizocilpine Maleate; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Rats; Receptors, AMPA; Stereoisomerism | 1994 |
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil | 1994 |
Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons.
Topics: Acute Disease; Afferent Pathways; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Cycloleucine; Inflammation; Knee Joint; Male; N-Methylaspartate; Neurons; Pain; Pressure; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cell Membrane; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Isoxazoles; Male; Organ Specificity; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Structure-Activity Relationship | 1994 |
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Male; Pyrimidinones; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Synaptic Membranes; Tritium; Uracil | 1995 |
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Pertussis Toxin; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Virulence Factors, Bordetella | 1993 |
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis | 1993 |
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Concanavalin A; Ganglia, Spinal; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neurons; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Magnetic Resonance Spectroscopy; Molecular Structure; N-Methylaspartate; Receptors, Metabotropic Glutamate | 1996 |
Stimulation of glutamine synthetase activity by excitatory amino acids in astrocyte cultures derived from aged mouse cerebral hemispheres may be associated with non-N-methyl-D-aspartate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Division; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamate-Ammonia Ligase; Glutamic Acid; Mice; N-Methylaspartate; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1996 |
Localisation and properties of AMPA-insensitive kainate sites: receptor autoradiography and gene expression in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Base Sequence; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Gene Expression Regulation; In Vitro Techniques; Male; Molecular Sequence Data; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Uracil | 1996 |
(S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Mice; Neurons; Pyrimidines; Receptors, Kainic Acid | 1996 |
Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain; Excitatory Amino Acid Agonists; In Vitro Techniques; Ligands; Male; Pyrimidines; Rats; Receptors, AMPA; Stereoisomerism; Thiocyanates | 1997 |
Metabotropic glutamate receptors depress vagal and aortic baroreceptor signal transmission in the NTS.
Topics: Action Potentials; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Pressoreceptors; Rabbits; Receptors, Metabotropic Glutamate; Solitary Nucleus; Synaptic Transmission; Vagus Nerve | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
Acetylcholinesterase potentiates [3H]fluorowillardiine and [3H]AMPA binding to rat cortical membranes.
Topics: Acetylcholinesterase; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blotting, Western; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA | 1999 |
Visualisation of AMPA binding sites in the brain stem of normotensive and hypertensive rats.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Stem; Denervation; Hypertension; Male; Neurons, Afferent; Nodose Ganglion; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Solitary Nucleus; Tissue Distribution; Vagus Nerve | 1999 |
The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alternative Splicing; Animals; Antihypertensive Agents; Benzothiadiazines; Binding Sites; Binding, Competitive; Cells, Cultured; Excitatory Amino Acid Agonists; Humans; Kidney; Pyrimidines; Rats; Receptors, AMPA; Tritium | 2000 |
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2001 |
Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice.
Topics: Acetylcysteine; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxidants; Brain; Catalase; Cell Death; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Electrons; Excitatory Amino Acid Agonists; Female; Humans; Kainic Acid; Male; Mice; Neurons; Peroxidases; Peroxiredoxins; Polyethylene Glycols; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors | 2003 |
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil | 2003 |
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Line; Female; Humans; Kainic Acid; Kinetics; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Nerve Fibers; Protein Subunits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Spinal Nerve Roots | 2004 |
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Topics: 2-Amino-5-phosphonovalerate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; N-Methylaspartate; Pyrazoles; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thermodynamics; Tritium | 2004 |
Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Blotting, Western; Cell Membrane; Cysteine; Dimerization; Dose-Response Relationship, Drug; Electrophysiology; Gene Deletion; GluK2 Kainate Receptor; Immunoprecipitation; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Oocytes; Phenotype; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; RNA, Complementary; Sequence Homology, Amino Acid; Software | 2005 |
Inhibition of hippocampal synaptic transmission by impairment of Ral function.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arabidopsis Proteins; Asparagine; Bacterial Toxins; Blotting, Western; Carbon Isotopes; Cells, Cultured; Drug Interactions; Electric Stimulation; Enterotoxins; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Glucose; Hippocampus; Membrane Potentials; Mutation; Neural Inhibition; Neurons; Patch-Clamp Techniques; ral GTP-Binding Proteins; Rats; Synaptic Transmission; Toxins, Biological; Transfection | 2005 |
Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Allosteric Site; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Membranes; Peptides, Cyclic; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tritium | 2006 |
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Antagonists; GluK2 Kainate Receptor; Glutamic Acid; Hydrogen Bonding; Models, Molecular; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Conformation; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Thymine; Xenopus laevis | 2006 |
Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Line; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Molecular Structure; Pyrimidinones; Rats; Receptors, Kainic Acid; Recombinant Proteins; Structure-Activity Relationship; Time Factors; Uracil | 2006 |
Chemical interplay in the mechanism of partial agonist activation in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Protein Binding; Protein Conformation; Protein Structure, Secondary; Pyrimidinones; Receptors, AMPA; Spectroscopy, Fourier Transform Infrared; Uracil | 2008 |
Protein kinase a mediates activity-dependent Kv4.2 channel trafficking.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Green Fluorescent Proteins; Hippocampus; Isoquinolines; Mutation; Neurons; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Serine; Shal Potassium Channels; Sulfonamides; Transfection | 2008 |
Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Baclofen; Benzothiadiazines; Biophysics; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; Galactolipids; Hippocampus; In Vitro Techniques; Interneurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Thymine | 2009 |
Ab initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid) and kainic acid (2S-(2 alpha, 3 beta, 4 beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Behavior; Brain; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Molecular Sequence Data; Mutation; Proline; Quantum Theory; Receptors, AMPA; Thermodynamics; Tyrosine | 2009 |
Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Green Fluorescent Proteins; Humans; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Receptors, Kainic Acid; Structure-Activity Relationship; Time Factors; Transfection; Tritium | 2010 |
Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Death; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dose-Response Relationship, Drug; Drug Resistance; Excitatory Amino Acid Agonists; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Pyrimidinones; Receptors, Glutamate; Species Specificity | 2010 |
Structure and assembly mechanism for heteromeric kainate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Line, Transformed; Chromatography, Gel; Crystallography; Crystallography, X-Ray; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Glutamic Acid; Humans; Membrane Potentials; Mice; Models, Molecular; Mutagenesis; Oocytes; Protein Structure, Tertiary; Pyrimidines; Receptors, AMPA; Receptors, Kainic Acid; Transfection; Xenopus | 2011 |
Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Brain-Derived Neurotrophic Factor; Calcium Channels; Calcium Signaling; Embryo, Mammalian; Gene Expression Regulation, Developmental; Glutamic Acid; Hippocampus; Kinetics; Primary Cell Culture; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Synapses; TOR Serine-Threonine Kinases; TRPV Cation Channels | 2015 |