alanine has been researched along with alaproclate in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (71.62) | 18.7374 |
| 1990's | 15 (20.27) | 18.2507 |
| 2000's | 5 (6.76) | 29.6817 |
| 2010's | 1 (1.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eneroth, P; Ross, SB; Syvälahti, E | 1 |
| Bartfai, T; Hedlund, B; Lindberg, UH; Ogren, SO | 1 |
| Jäkälä, P; Riekkinen, P; Sirviö, J; Valjakka, A | 1 |
| Riekkinen, P; Sirviö, J | 1 |
| Sommerfelt, L; Ursin, R | 2 |
| Jäkälä, P; Riekkinen, P; Sirviö, J | 1 |
| Ross, SB | 3 |
| Brodin, E; Ogren, SO; Theodorsson-Norheim, E | 1 |
| Hedlund, B | 2 |
| Brodin, E; Brodin, K; Iwarsson, K; Ogren, SO; Rosén, A | 1 |
| Fasmer, OB; Hole, K; Hunskaar, S | 1 |
| Altman, HJ; Dilsaver, SC; Normile, HJ | 1 |
| Bjorvatn, B; Sommerfelt, L; Underland, G; Ursin, R | 1 |
| Horn, AM; Watts, AG | 1 |
| Aberg-Wistedt, A; Alvariza, M; Bertilsson, L; Malmgren, R; Wachtmeister, H | 1 |
| Alberts, P; Ogren, SO | 1 |
| Andersen, P; Hedlund, B | 1 |
| Aberg-Wistedt, A; Asberg, M; Bertilsson, L; Mårtensson, B; Montero, D; Wägner, A | 1 |
| Bartfai, T; Iverfeldt, K; Ogren, SO | 1 |
| Fowler, CJ; Ogren, SO; Thorell, G | 1 |
| Bidziński, A; Hauptmann, M; Kostowski, W; Płaźnik, A; Tamborska, E | 1 |
| Fuller, RW | 1 |
| Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A | 1 |
| Smith, DF | 1 |
| Rényi, L | 1 |
| Hauge, ER; Sommerfelt, L; Ursin, R | 1 |
| Archer, T; Danysz, W; Hiltunen, AJ; Järbe, TU; Kostowski, W; Malatynska, E; Plaznik, A | 1 |
| Eide, PK; Hole, K | 1 |
| Bartfai, T; Danielsson, E; Nordström, O; Ogren, SO; Peterson, LL | 1 |
| Altman, HJ | 1 |
| Ask, AL; Fowler, CJ; Hall, H; Kelder, D; Ross, SB; Sääf, J | 1 |
| Davis, KL; Hollander, E; Mohs, RC | 1 |
| Fink, G; Horn, AM | 1 |
| Hole, DR; Hunter, AJ; Wilson, CA | 1 |
| Phillips, OM; Williams, DC; Wood, KM | 1 |
| Gawell, L; Hall, H; Ross, SB | 1 |
| Altman, HJ; Ogren, SO; Stone, WS | 1 |
| Dehlin, O; Hedenrud, B; Jansson, P; Nörgård, J | 1 |
| Checkley, SA; Thompson, C | 1 |
| Bartfai, T; Carlsson, S; Ogren, SO | 1 |
| Bolger, MB; Lee, JD; Ransom, RW; Shih, JC | 1 |
| Hall, H; Wedel, I | 1 |
| Hall, H; Ross, SB | 1 |
| Hall, H; Holm, AC; Lindberg, UH; Ogren, SO | 1 |
| Archer, T; Minor, BG; Ross, SB | 1 |
| Archer, T; Johansson, G; Ogren, SO; Ross, SB | 1 |
| Altman, HJ; Nordy, DA; Ogren, SO | 1 |
| Hall, H; Ross, SB; Sällemark, M | 1 |
| Bergman, I; Bråne, G; Gottfries, CG; Jostell, KG; Karlsson, I; Svennerholm, L | 1 |
| Calverley, PM; Carmichael, GL; Scott, DB | 1 |
| Eccleston, D; Frost, SJ; Hassanyeh, F; Marshall, EF | 1 |
| Holm, AC; Ogren, SO | 1 |
| Breimer, DD; Teunissen, MW; Vinnars, E; Wahlén, A | 1 |
| Graffner, C; Lindgren, JE; Nicklasson, M | 1 |
| Pawłowski, L; Przegaliński, E; Rawłów, A | 1 |
| Brodin, A; Nicklasson, M | 1 |
| Brodin, E; Franck, J; Rosén, A | 1 |
| Goldstein, DS; Kopin, IJ; Pacak, K; Yadid, G | 1 |
| Rogawski, MA; Svensson, BE; Werkman, TR | 1 |
| Akerman, KE; Courtney, M; Hallnemo, G; Westlind-Danielsson, A; Wilkinson, A | 1 |
| Chai, CY; Chen, WY; Cheng, FC; Kuo, JS; Li, HT; Liu, L; Yang, CS | 1 |
| Allard, P; Marcusson, JO; Ross, SB | 1 |
| Hu, PS; Ross, SB | 1 |
| Friedman, RD; Hull, EM; Lorrain, DS; Matuszewich, L | 1 |
| Czoty, PW; Ginsburg, BC; Howell, LL | 1 |
| Balster, RL; Harvey, SA; Nicholson, KL; Wiley, JL | 1 |
| Alkon, DL; Sun, MK | 1 |
| Cheng, FC; Chiu, YT; Gong, CL; Kuo, JS; Lin, NN; Lin, SZ | 1 |
| Clark, TM; Hirschler, AN; Lawecki, JL; Samandu, TR; Shepherd, JJ | 1 |
| Badimon, L; Casani, L; Estruch, R; Lamuela-Raventos, RM; Mendieta, G; Vilahur, G | 1 |
3 review(s) available for alanine and alaproclate
| Article | Year |
|---|---|
Biochemical pharmacology of the serotonin system.
Topics: Alanine; Brain; Citalopram; Clomipramine; Fenfluramine; Fluoxetine; Fluvoxamine; Humans; Monoamine Oxidase Inhibitors; Neurons; Oximes; p-Chloroamphetamine; Paroxetine; Piperidines; Propylamines; Receptors, Serotonin; Reserpine; Serotonin; Serotonin Antagonists; Synapses; Tetrabenazine; Zimeldine | 1986 |
Therapeutic effects of serotonin uptake inhibitors in depression.
Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine | 1986 |
Cholinergic approaches to the treatment of Alzheimer's disease.
Topics: 4-Aminopyridine; Alanine; Alzheimer Disease; Aminopyridines; Arecoline; Clinical Trials as Topic; Humans; Parasympathomimetics; Physostigmine; Piracetam; Pyrrolidines; Research Design; Succinimides; Synapses | 1986 |
5 trial(s) available for alanine and alaproclate
| Article | Year |
|---|---|
Alaproclate a novel antidepressant? A biochemical and clinical comparison with zimeldine.
Topics: Adult; Aged; Alanine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Serotonin; Serotonin Antagonists; Zimeldine | 1985 |
Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder.
Topics: Adult; Aged; Alanine; Antidepressive Agents; Blood Platelets; Carrier Proteins; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Outcome and Process Assessment, Health Care; Psychiatric Status Rating Scales; Receptors, Drug; Receptors, Neurotransmitter; Receptors, Serotonin; Zimeldine | 1987 |
Cholinergic approaches to the treatment of Alzheimer's disease.
Topics: 4-Aminopyridine; Alanine; Alzheimer Disease; Aminopyridines; Arecoline; Clinical Trials as Topic; Humans; Parasympathomimetics; Physostigmine; Piracetam; Pyrrolidines; Research Design; Succinimides; Synapses | 1986 |
A double-blind comparison of alaproclate and placebo in the treatment of patients with senile dementia.
Topics: Aged; Alanine; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; Humans; Intelligence; Male; Neuropsychological Tests | 1985 |
Effects of alaproclate and morphine on the ventilatory response to carbon dioxide in normal man.
Topics: Adult; Alanine; Carbon Dioxide; Depression, Chemical; Drug Synergism; Humans; Male; Morphine; Respiration; Time Factors | 1983 |
67 other study(ies) available for alanine and alaproclate
| Article | Year |
|---|---|
Acute effects of zimelidine and alaproclate, two inhibitors of serotonin uptake, on neuroendocrine function.
Topics: Adult; Alanine; Blood Platelets; Brompheniramine; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Growth Hormone; Humans; Hydrocortisone; In Vitro Techniques; Luteinizing Hormone; Male; Pituitary Hormones, Anterior; Prolactin; Pyridines; Serotonin; Serotonin Antagonists; Thyrotropin; Zimeldine | 1979 |
GEA 857, a putative blocker of potassium conductance, enhances muscarinic agonist-evoked responses: dissociation from an action on 5-HT mechanisms.
Topics: Alanine; Animals; Antidepressive Agents; Brain; Male; Motor Activity; Parasympathomimetics; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Selective Serotonin Reuptake Inhibitors; Serotonin; Valine | 1992 |
The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats.
Topics: Alanine; Animals; Antidepressive Agents; Biogenic Monoamines; Brain Chemistry; Cues; Fenclonine; Male; Psychomotor Performance; Rats; Rats, Inbred Strains; Serotonin; Swimming | 1992 |
Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.
Topics: Aging; Alanine; Animals; Antidepressive Agents; Electroencephalography; Electrophysiology; Imidazoles; Male; Methysergide; Ondansetron; Pilocarpine; Rats; Rats, Inbred Strains; Scopolamine; Serotonin Antagonists | 1991 |
Behavioral, sleep-waking and EEG power spectral effects following the two specific 5-HT uptake inhibitors zimeldine and alaproclate in cats.
Topics: Alanine; Animals; Behavior, Animal; Cats; Electroencephalography; Female; Hallucinations; Interpersonal Relations; Male; Motor Activity; Serotonin Antagonists; Sleep; Sleep Stages; Sleep, REM; Wakefulness; Zimeldine | 1991 |
The effects of increased serotonergic and decreased cholinergic activities on spatial navigation performance in rats.
Topics: Alanine; Animals; Antidepressive Agents; Cues; Male; Parasympathetic Nervous System; Pilocarpine; Psychomotor Performance; Rats; Rats, Inbred Strains; Scopolamine; Serotonin; Space Perception | 1991 |
Further studies on the high-affinity binding of 3H-alaproclate to membranes from rat liver and some other tissues.
Topics: Adrenal Glands; Alanine; Animals; Binding Sites; In Vitro Techniques; Kidney; Kinetics; Liver; Male; Membranes; Microsomes, Liver; Myocardium; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stereoisomerism; Subcellular Fractions | 1990 |
Effects of subchronic treatment with imipramine, zimelidine and alaproclate on regional tissue levels of substance P- and neurokinin A/neurokinin B-like immunoreactivity in the brain and spinal cord of the rat.
Topics: Alanine; Animals; Antidepressive Agents; Brain Chemistry; Central Nervous System; Imipramine; Immune Sera; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Zimeldine | 1987 |
Alaproclate inhibits potassium currents and thereby enhances muscarinic stimulation in N1E-115 neuroblastoma cells.
Topics: Alanine; Antidepressive Agents; Calcium Radioisotopes; Carbachol; Cells, Cultured; Ion Channels; Membrane Potentials; Microelectrodes; Neuroblastoma; Parasympathomimetics; Rubidium Radioisotopes | 1987 |
Alaproclate affects membrane ion channels in GH3/B6 pituitary cells.
Topics: Action Potentials; Alanine; Aminopyridines; Antidepressive Agents; Cell Membrane; Ion Channels; Pituitary Gland | 1987 |
Increased levels of substance P and cholecystokinin in rat cerebral cortex following repeated electroconvulsive shock and subchronic treatment with a serotonin uptake inhibitor.
Topics: Alanine; Animals; Cerebral Cortex; Cholecystokinin; Electroshock; Male; Rats; Rats, Inbred Strains; Serotonin Antagonists; Substance P | 1989 |
Antinociceptive effects of serotonergic reuptake inhibitors in mice.
Topics: Alanine; Analgesics; Animals; Citalopram; Clomipramine; Desipramine; Formaldehyde; Hot Temperature; Male; Mice; Neurotransmitter Uptake Inhibitors; Serotonin Antagonists; Substance P | 1989 |
Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats.
Topics: Alanine; Animals; Antidepressive Agents; Body Temperature; Drug Synergism; Male; Oxotremorine; p-Chloroamphetamine; Rats; Rats, Inbred Strains | 1989 |
Increased waking as well as increased synchronization following administration of selective 5-HT uptake inhibitors to rats.
Topics: Alanine; Animals; Antidepressive Agents; Arousal; Brain; Cortical Synchronization; Dose-Response Relationship, Drug; Drinking; Eating; Electroencephalography; Evoked Potentials; Fenclonine; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Serotonin; Sleep Stages; Wakefulness; Zimeldine | 1989 |
Effects of 5-hydroxytryptamine uptake blockers on the concentration in brain of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male rats, pro-oestrous rats and ovariectomized rats treated with oestrogen and progesterone.
Topics: Alanine; Animals; Brain; Castration; Estradiol; Female; Hydroxyindoleacetic Acid; Hypothalamus; Male; Pregnancy; Proestrus; Progesterone; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Zimeldine | 1985 |
Effects of alaproclate, potassium channel blockers, and lidocaine on the release of 3H-acetylcholine from the guinea-pig ileum myenteric plexus.
Topics: Acetylcholine; Alanine; Animals; Antidepressive Agents; Cholinergic Fibers; Electric Stimulation; Guinea Pigs; Ileum; Lidocaine; Myenteric Plexus; Norepinephrine; Potassium Channels; Sympathetic Nervous System; Tritium | 1989 |
Alaproclate increases the excitability of hippocampal CA1 pyramidal cells and blocks the slow after-hyperpolarization.
Topics: Alanine; Animals; Antidepressive Agents; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Pyramidal Tracts; Rats; Rats, Inbred Strains | 1989 |
Substance P receptors in the rat spinal cord: the effect of GTP and of chronic antidepressant treatment.
Topics: Alanine; Animals; Antidepressive Agents; Guanosine Triphosphate; Imipramine; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Zimeldine | 1988 |
Investigation into the effects in-vitro of the 5-hydroxytryptamine reuptake inhibitor, alaproclate, on carbachol-stimulated inositol phospholipid breakdown in the rat cerebral cortex.
Topics: Alanine; Animals; Antidepressive Agents; Carbachol; Cerebral Cortex; In Vitro Techniques; Inositol; Inositol Phosphates; Male; Rats; Rats, Inbred Strains; Sugar Phosphates | 1987 |
Brain neurotransmitter systems mediating behavioral deficits produced by inescapable shock treatment in rats.
Topics: Alanine; Amphetamine; Animals; Antidepressive Agents; Atropine; Brain; Desipramine; Diazepam; Electroshock; Escape Reaction; Male; Motor Activity; Neurotransmitter Agents; Physostigmine; Rats; Rats, Inbred Strains; Valproic Acid | 1988 |
The stereoselectivity of serotonin uptake in brain tissue and blood platelets: the topography of the serotonin uptake area.
Topics: Alanine; Amphetamine; Aniline Compounds; Animals; Antidepressive Agents; Blood Platelets; Brain; Fluoxetine; Humans; Male; Methadone; Mianserin; Mirtazapine; Morpholines; Naphthalenes; Nefopam; Nomifensine; Paroxetine; Piperidines; Rabbits; Serotonin; Stereoisomerism; Tranylcypromine; Viloxazine; Zimeldine | 1986 |
The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N,N-dimethyltryptamine-induced ejaculation in the rat.
Topics: Alanine; Animals; Behavior, Animal; Citalopram; Ejaculation; Fluoxetine; Male; Metergoline; Methoxydimethyltryptamines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Time Factors; Zimeldine | 1986 |
Similar effect on REM sleep but differential effect on slow wave sleep of the two 5-HT uptake inhibitors zimeldine and alaproclate in cats and rats.
Topics: Alanine; Animals; Brain; Cats; Electroencephalography; Female; Male; Neurotransmitter Uptake Inhibitors; Rats; Serotonin; Sleep Stages; Species Specificity; Zimeldine | 1987 |
The effects of zimeldine and alaproclate combined with a small dose of 5-HTP on waking and sleep stages in cats.
Topics: 5-Hydroxytryptophan; Alanine; Animals; Cats; Drug Synergism; Electroencephalography; Female; Male; Sleep Stages; Sleep, REM; Wakefulness; Zimeldine | 1987 |
Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs.
Topics: Alanine; Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Male; Rats; Rats, Inbred Strains; Time Factors; Zimeldine | 1988 |
Acute and chronic treatment with selective serotonin uptake inhibitors in mice: effects on nociceptive sensitivity and response to 5-methoxy-N,N-dimethyltryptamine.
Topics: Alanine; Animals; Biological Transport, Active; Clomipramine; Male; Methoxydimethyltryptamines; Mice; Nociceptors; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Zimeldine | 1988 |
In vivo and in vitro studies on the potentiation of muscarinic receptor stimulation by alaproclate, a selective 5-HT uptake blocker.
Topics: Alanine; Animals; Brain; Cyclic GMP; Drug Synergism; Hippocampus; Male; Mice; Oxotremorine; Physostigmine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Serotonin; Tremor | 1985 |
Mediation of storage and retrieval with two drugs that selectively modulate serotonergic neurotransmission.
Topics: Alanine; Animals; Avoidance Learning; Memory; Mental Recall; Piperidines; Rats; Retention, Psychology; Serotonin; Synaptic Transmission | 1985 |
Cortical beta- and alpha 2- adrenoceptor binding, hypothalamic noradrenaline and pineal melatonin concentrations measured at different times of the day after repeated treatment of rats with imipramine, zimeldine, alaproclate and amiflamine.
Topics: Alanine; Animals; Antidepressive Agents; Body Weight; Cerebral Cortex; Circadian Rhythm; Dihydroalprenolol; Hypothalamus; Imipramine; Kinetics; Male; Melatonin; Norepinephrine; Phenethylamines; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Zimeldine | 1986 |
Effects of 5-hydroxytryptamine uptake blockers on the release of LH and prolactin in several different experimental steroid models in the rat.
Topics: Alanine; Animals; Castration; Estradiol; Female; Luteinizing Hormone; Pituitary Gland, Anterior; Pregnancy; Proestrus; Progesterone; Prolactin; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Zimeldine | 1985 |
Studies into the dual effects of serotonergic pharmacological agents on female sexual behaviour in the rat: preliminary evidence that endogenous 5HT is stimulatory.
Topics: 5-Hydroxytryptophan; Adrenalectomy; Alanine; Animals; Castration; Cinanserin; Female; Ketanserin; Metergoline; Methysergide; Mianserin; Piperidines; Progesterone; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Sexual Behavior, Animal; Zimeldine | 1985 |
Kinetics of the interaction of sertraline with the human platelet plasma membrane 5-hydroxytryptamine carrier.
Topics: 1-Naphthylamine; Alanine; Binding, Competitive; Blood Platelets; Cell Membrane; Humans; Imipramine; In Vitro Techniques; Naphthalenes; Receptors, Serotonin; Serotonin; Sertraline | 1988 |
Proadifen-sensitive high affinity binding of 3H-alaproclate to liver membranes.
Topics: Alanine; Animals; Antidepressive Agents; Binding, Competitive; Cell Membrane; In Vitro Techniques; Kinetics; Liver; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Subcellular Fractions | 1987 |
Stereoselective high-affinity binding of 3H-alaproclate to membranes from rat cerebral cortex.
Topics: Alanine; Animals; Antidepressive Agents; Binding, Competitive; Cell Membrane; Cerebral Cortex; Imipramine; In Vitro Techniques; Kinetics; Male; Proadifen; Rats; Rats, Inbred Strains; Stereoisomerism; Subcellular Fractions | 1987 |
Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrieval.
Topics: Acetylcholine; Alanine; Animals; Avoidance Learning; Brain; Cholinergic Fibers; Drug Interactions; Male; Memory; Mice; Oxotremorine; Quipazine; Scopolamine; Serotonin | 1987 |
The effects of alaproclate on the pupillary responses to tyramine, phenylephrine and pilocarpine in depressed patients.
Topics: Alanine; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Phenylephrine; Pilocarpine; Pupil; Serotonin Antagonists; Sympathomimetics; Time Factors; Tyramine | 1985 |
Serotonergic potentiation of muscarinic agonist evoked tremor and salivation in rat and mouse.
Topics: Alanine; Animals; Arecoline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Oxotremorine; Parasympathomimetics; Physostigmine; Rats; Rats, Inbred Strains; Salivation; Serotonin; Serotonin Antagonists; Tremor | 1985 |
Photoinactivation of serotonin uptake by an arylazido derivative of 5-hydroxytryptamine.
Topics: Affinity Labels; Alanine; Animals; Azides; Binding, Competitive; Biological Transport; Cerebral Cortex; Fenfluramine; Kinetics; Male; p-Chloroamphetamine; Photochemistry; Rats; Serotonin; Serotonin Antagonists; Spectrum Analysis | 1985 |
The effects of manipulation of presynaptic 5-HT nerve terminals on postsynaptic 5-HT1 and 5-HT2 binding sites of the rat brain.
Topics: Alanine; Animals; Antidepressive Agents; Binding Sites; Brain; Male; Nerve Endings; p-Chloroamphetamine; Phenethylamines; Rats; Rats, Inbred Strains; Serotonin; Synapses | 1985 |
Maximal turnover number of the membranal serotonin carrier in rat brain synaptosomes in vitro.
Topics: Alanine; Animals; Brain; Hydroxyindoleacetic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin; Synaptic Membranes; Zimeldine | 1983 |
Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia.
Topics: Alanine; Animals; Antidepressive Agents, Tricyclic; Brain; Dopamine; Drug Synergism; Hydroxyindoleacetic Acid; Male; Mice; Molecular Conformation; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Serotonin; Spinal Cord | 1984 |
Attenuation of the post-decapitation convulsions after repeated treatment of rats with desipramine, imipramine and maprotiline.
Topics: Alanine; Animals; Anticonvulsants; Antidepressive Agents; Desipramine; Imipramine; Male; Maprotiline; Rats; Rats, Inbred Strains; Time Factors; Zimeldine | 1984 |
The effect of acute zimeldine and alaproclate administration on the acquisition of two-way active avoidance: comparison with other antidepressant agents, test of selectivity and sub-chronic studies.
Topics: Alanine; Animals; Antidepressive Agents; Avoidance Learning; Clomipramine; Fenclonine; Male; Mianserin; Rats; Rats, Inbred Strains; Serotonin Antagonists; Zimeldine | 1984 |
Role of serotonin in memory: facilitation by alaproclate and zimeldine.
Topics: Alanine; Animals; Avoidance Learning; Cyproheptadine; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Male; Memory; Mice; Quipazine; Serotonin; Time Factors; Zimeldine | 1984 |
Effect of destruction of central noradrenergic and serotonergic nerve terminals by systemic neurotoxins on the long-term effects of antidepressants on beta-adrenoceptors and 5-HT2 binding sites in the rat cerebral cortex.
Topics: Alanine; Amines; Animals; Antidepressive Agents; Benzylamines; Binding Sites; Cerebral Cortex; Clenbuterol; Desipramine; Dihydroalprenolol; Male; Mianserin; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Spiperone; Zimeldine | 1984 |
Alaproclate: a pharmacokinetic and biochemical study in patients with dementia of Alzheimer type.
Topics: Aged; Alanine; Alzheimer Disease; Dementia; Female; Humans; Kinetics; Male; Serotonin | 1983 |
Alaproclate--an open clinical study in depressive illness.
Topics: Adult; Aged; Alanine; Antidepressive Agents; Blood Platelets; Female; Humans; Kinetics; Male; Middle Aged; Psychiatric Status Rating Scales; Serotonin | 1984 |
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia.
Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; p-Chloroamphetamine; Pain; Pyridines; Rats; Serotonin; Zimeldine | 1980 |
Influence of alaproclate on antipyrine metabolite formation in man.
Topics: Adult; Alanine; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Edaravone; Half-Life; Humans; Liver; Male; Oxidation-Reduction | 1984 |
Correlations between in vitro dissolution rate and bioavailability of alaproclate tablets.
Topics: Absorption; Adult; Alanine; Biological Availability; Humans; In Vitro Techniques; Kinetics; Male; Random Allocation; Solubility; Tablets; Time Factors | 1984 |
Alaproclate: further pharmacological evidence for 5-HT uptake inhibition in vivo.
Topics: Alanine; Animals; Central Nervous System; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reflex; Serotonin; Stomach | 1983 |
A rotating disk method to study the influence of binding agents on the dissolution rate.
Topics: Alanine; Chemistry, Pharmaceutical; Excipients; Solubility; Tablets | 1982 |
Effects of acute systemic treatment with the 5 HT-uptake blocker alaproclate on tissue levels and release of substance P in rat periaqueductal grey.
Topics: 5,7-Dihydroxytryptamine; Alanine; Animals; Cholecystokinin; Kinetics; Male; Morphine; Neurokinin A; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Substance P | 1995 |
Comparison of high affinity binding of 3H-proadifen and 3H-(-)-cocaine to rat liver membranes.
Topics: Alanine; Animals; Binding, Competitive; Cadmium; Cadmium Chloride; Chlorides; Cocaine; Liver; Male; Microsomes, Liver; Proadifen; Rats; Rats, Sprague-Dawley; Subcellular Fractions | 1995 |
Endogenous serotonin stimulates striatal dopamine release in conscious rats.
Topics: 5,7-Dihydroxytryptamine; Alanine; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Male; Microdialysis; Perfusion; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists | 1994 |
Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K+ channel cDNA.
Topics: Alanine; Animals; Antidepressive Agents; Cell Line, Transformed; DNA, Complementary; Extracellular Space; Fibroblasts; Hippocampus; Neurons; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1994 |
Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.
Topics: Alanine; Animals; Antidepressive Agents; Calcium; Cells, Cultured; Cerebellum; Glycine; Magnesium; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 1994 |
The dorsal facial area of the medulla in cats: inhibitory action of serotonin on glutamate release in regulating common carotid blood flow.
Topics: Alanine; Animals; Carotid Artery, Common; Cats; Cerebrovascular Circulation; Female; Glutamic Acid; Male; Medulla Oblongata; Microdialysis; Potassium Chloride; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereotaxic Techniques | 1996 |
[3H]WIN 35,428 binding in the human brain.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Frontal Lobe; Humans; Male; Middle Aged; Paroxetine; Radioligand Assay; Selective Serotonin Reuptake Inhibitors | 1996 |
NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
Topics: 4-Aminopyridine; Alanine; Animals; Behavior, Animal; Cerebellum; Convulsants; Cyclic GMP; Drug Interactions; Harmaline; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Selective Serotonin Reuptake Inhibitors; Valine | 1997 |
Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation in male rats.
Topics: Alanine; Animals; Copulation; Ejaculation; Erectile Dysfunction; Extracellular Space; Hypothalamus; Locomotion; Male; Microdialysis; Microinjections; Preoptic Area; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin | 1997 |
Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys.
Topics: Alanine; Animals; Behavior, Animal; Brain Chemistry; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Infusions, Intravenous; Male; Microdialysis; Quipazine; Receptors, Serotonin; Reinforcement, Psychology; Saimiri; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists | 2002 |
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats.
Topics: Acoustic Stimulation; Adrenergic Uptake Inhibitors; Alanine; Amantadine; Animals; Binding Sites; Desipramine; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ibogaine; Loudness Perception; Male; Memantine; Muscarinic Antagonists; Neural Inhibition; Orphenadrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Selective Serotonin Reuptake Inhibitors | 2003 |
Open space swimming test to index antidepressant activity.
Topics: Alanine; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Imipramine; Iproniazid; Mianserin; Motor Activity; Predictive Value of Tests; Rats; Rats, Inbred WF; Rats, Wistar; Swimming; Treatment Outcome | 2003 |
Inhibitory actions of serotonin on glutamate release in dorsal medulla suppress systemic arterial pressure of cats.
Topics: Alanine; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Glutamic Acid; Male; Medulla Oblongata; Microdialysis; Neural Inhibition; Potassium Chloride; Presynaptic Terminals; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptic Transmission; Up-Regulation | 2004 |
Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis?
Topics: Acid-Base Equilibrium; Aedes; Alanine; Animals; Body Water; Hemolymph; Hydrogen-Ion Concentration; Larva; Lethal Dose 50; Methiothepin; Osmotic Pressure; Quipazine; Salinity; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Serotonin Antagonists; Sodium | 2009 |
Beer elicits vasculoprotective effects through Akt/eNOS activation.
Topics: Acetylcholine; Alanine; Animals; Beer; Cholesterol; Coronary Artery Disease; Coronary Vessels; Diet, Western; Dyslipidemias; Endothelium, Vascular; Enzyme Inhibitors; Ethanol; Female; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Oncogene Protein v-akt; Oxidative Stress; Random Allocation; Sus scrofa; Swine; Triglycerides; Vasodilation; Vasodilator Agents | 2014 |