alanine has been researched along with alanosine in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (59.46) | 18.7374 |
| 1990's | 14 (18.92) | 18.2507 |
| 2000's | 12 (16.22) | 29.6817 |
| 2010's | 2 (2.70) | 24.3611 |
| 2020's | 2 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Seegmiller, JE; Willis, RC | 1 |
| Graff, JC; Plagemann, PG | 1 |
| Adamson, RH; Anandaraj, S; Cooney, DA; Jayaram, HN; Kelley, JM | 1 |
| Adamson, RH; Anandaraj, S; Cooney, DA; Jayaram, HN; Kelley, J; Kelley, JA; Montgomery, JA; Tyagi, AK | 1 |
| Ames, MM; Powis, G | 1 |
| Dye, FJ; Kollar, EJ | 1 |
| Kratsas, RG | 1 |
| Boyd, JF; Budd, T; Fabian, C; Green, SJ; Neidhart, JA; Osborne, CK; Von Hoff, DD | 1 |
| Alfieri, AA; Hong, SS; Kim, JH; Kim, SH | 1 |
| Bingham, H; Chan, VL; Du, RP; Juranka, P; Pang, JC | 1 |
| Ahluwalia, G; Broder, S; Cooney, DA; Dalal, M; Flora, KP; Fridland, A; Hao, Z; Johns, DG; Mitsuya, H | 1 |
| Daniels, R; Flickinger, RA; Gerbracht, T | 1 |
| Carbone, PP; Davis, TE; Earle, JD; Elson, PJ; Glover, DJ; Hahn, RG; Kvols, LK; Trump, DL; Vogl, SE | 1 |
| Allan, PW; Bennett, LL; Brockman, RW; Rose, LM; Shaddix, SC | 1 |
| Chang, M; Creagan, ET; Cullinan, SA; Ebbert, L; Mailliard, JA; Morton, RF; Veeder, MH | 1 |
| Martin, GM; Turker, MS | 1 |
| Baillon, J; Hervé, G; Tauc, P | 1 |
| Assandri, A; Barone, D; Galliani, G; Grandi, M; Lancini, GC; Mistrello, G | 1 |
| Watts, RW | 1 |
| Kvols, LK; Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ | 1 |
| Powis, G | 1 |
| Bean, TL; Walker, MD; Webster, HK; Whaun, JM | 1 |
| Cooney, DA; Tyagi, AK | 2 |
| Bassi, L; Mistrello, G | 1 |
| Adwankar, MK; Amonkar, AJ; Chitnis, MP | 1 |
| Ahmann, DL; Creagan, ET; Green, SJ; Long, HJ | 1 |
| Cheng, HW; Rice, A; Verham, R; Wang, AL; Wang, CC | 1 |
| Allsop, J; Watts, RW | 1 |
| Creagan, ET; Ingle, JN; O'Fallon, JR; Schutt, AJ | 1 |
| Morrison, FS; Tranum, BL; Weick, JK | 1 |
| El Sayed, YM; Nguyen, BT; Sadée, W | 1 |
| Goldsmith, MA; Greenspan, EM; Holland, JF; Ohnuma, T; Spigelman, M | 1 |
| Hahn, RG; Hineman, V; Moertel, CG; Rubin, J; Schutt, AJ | 1 |
| Creagan, ET; Kovach, JS; O'Connell, MJ | 1 |
| Cadman, E; Goldberg, D; Heimer, R | 1 |
| Bodey, GP; Burgess, MA; Dosik, GM; Stewart, D; Valdivieso, M | 1 |
| Alston, TA; Bright, HJ | 1 |
| Cooney, DA; Jayaram, HN; Johnson, RK; Swiniarski, JK; Tyagi, AK | 1 |
| Kovach, JS; Powis, G | 1 |
| Koch, MR; Lea, MA | 1 |
| Cooney, DA; McGee, E; Thake, DC; Tyagi, AK | 1 |
| Anandaraj, SJ; Chitnis, M; Cooney, DA; Han, N; Jayaram, HN; Montgomery, JA; Thomas, JH; Tyagi, AK | 1 |
| Gupta, RS | 1 |
| Ahmed, N; Weidemann, MJ | 1 |
| Meredith, M; Metz, S; Rabaglia, M | 1 |
| Datta, SK; Guicherit, OM; Kellems, RE | 1 |
| Downs, SM | 1 |
| Haigh, JR; Houben, K; Howard, BD; Ramachandran, B; Rozenberg, YY; Varpetian, A | 1 |
| Cooper, BF; Guicherit, OM; Kellems, RE; Rudolph, FB | 1 |
| Christopherson, RI; Clark, JM; Dunn, IS; Musk, P; Parsons, PG; Rose, SE; Szabados, E; Thompson, D | 1 |
| Chan, PK; Finch, RA | 1 |
| Batova, A; Bridgeman, L; Diccianni, MB; Nobori, T; Vu, T; Yu, AL; Yu, J | 1 |
| Bromberg, Y; Brosh, S; Danziger, E; Sidi, Y; Sperling, O; Zoref-Shani, E | 1 |
| Carrera, CJ; Carson, DA; Hori, H; Hori, Y; Nobori, T; Rosenbach, MD; Tran, P | 1 |
| Batova, A; Carrera, CJ; Shao, L; Yu, AL; Yu, J | 1 |
| Amylon, MD; Batova, A; Bridgeman, LJ; Carrera, CJ; Diccianni, MB; Kung, FH; Omura-Minamisawa, M; Pullen, J; Yu, AL; Yu, J | 1 |
| Dagher, PC | 1 |
| Yu, J | 1 |
| Efferth, T; Gebhart, E; Ross, DD; Sauerbrey, A | 1 |
| Demers, R; Elliott, G; Gantverg, A; Pineault, J | 1 |
| Bertino, JR; Cole, P; Gorlick, R; Gu, B; Li, W; Martin, DS; Mizobuchi, H; Su, D | 1 |
| Caldas, C; Capella, G | 1 |
| Batova, A; Carrera, CJ; Cottam, H; Diccianni, MB; Yu, AL; Yu, J | 1 |
| Huang, J; Lipscomb, WN | 1 |
| Carrière, J; Crépin, D; Elliott, G; Guettier, C; Kanekal, S; Lévi, F; Li, XM | 1 |
| Bilodeau-Goeseels, S; Guillemette, C; Richard, FJ; Sasseville, M | 1 |
| Bonomo, J; Gill, RT; Lynch, MD; Price, JV; Warnecke, T | 1 |
| Burris, HA; Kindler, HL; Oliff, IA; Sandler, AB | 1 |
| Efferth, T | 1 |
| Benz, C; Cadman, E; Heimer, R; O'Shaughnessy, J | 1 |
| Chen, LT; Fang, FM; Huang, HY; Kung, HJ; Li, CF; Li, SH; Tsai, JW; Wang, JW; Wang, YH; Yu, SC | 1 |
| Balskus, EP; McCallum, ME; Ng, TL; Wang, JX; Wu, KJY; Zheng, CR | 1 |
| Daniel-Ivad, P; He, HY; Niikura, H; Ryan, KS; Wang, M | 1 |
5 review(s) available for alanine and alanosine
| Article | Year |
|---|---|
Some regulatory and integrative aspects of purine nucleotide biosynthesis and its control: an overview.
Topics: Adenylosuccinate Synthase; Alanine; Animals; Brain; Formates; Humans; IMP Dehydrogenase; Inosine Monophosphate; Liver; Lymphocyte Activation; Purine Nucleotides; Rats; Ribavirin; Ribonucleotides; S-Adenosylhomocysteine | 1983 |
Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man.
Topics: Alanine; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Ifosfamide; Kinetics; Methotrexate; Thymidine | 1983 |
Biochemical pharmacology, metabolism, and mechanism of action of L-alanosine, a novel, natural antitumor agent.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Antiviral Agents; Bacteria; Chemical Phenomena; Chemistry; Drug Evaluation; Drug Resistance; Humans; Immunosuppressive Agents; Kinetics; Stereoisomerism | 1984 |
Alanosine (UCSD).
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Humans | 2001 |
Personalized cancer medicine: from molecular diagnostics to targeted therapy with natural products.
Topics: Alanine; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Biomarkers, Tumor; Cytogenetics; Drug Resistance, Neoplasm; ErbB Receptors; Genetic Variation; Humans; Neoplasms; Phytotherapy; Precision Medicine; RNA, Messenger | 2010 |
4 trial(s) available for alanine and alanosine
| Article | Year |
|---|---|
Phase II study of L-alanosine (NSC 153353) in patients with advanced breast cancer. A Southwest Oncology Group study.
Topics: Adenocarcinoma; Adult; Aged; Alanine; Antibiotics, Antineoplastic; Breast Neoplasms; Drug Evaluation; Female; Humans; Middle Aged | 1991 |
Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma.
Topics: Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cimetidine; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged; Phosphonoacetic Acid; Pleural Neoplasms; Soft Tissue Neoplasms | 1987 |
Clinical trial of PALA and L-Alanosine in advanced colorectal carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Nausea; Phosphonoacetic Acid; Rectal Neoplasms; Stomatitis | 1983 |
A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer.
Topics: Adenine; Adolescent; Adult; Aged; Alanine; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylase | 2009 |
65 other study(ies) available for alanine and alanosine
| Article | Year |
|---|---|
Increases in purine excretion and rate of synthesis by drugs inhibiting IMP dehydrogenase or adenylosuccinate synthetase activities.
Topics: Adenylosuccinate Synthase; Alanine; Animals; Cell Line; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Ligases; Lymphocytes; Mycophenolic Acid; Nitrosamines; Purines; Ribonucleotides; Spleen | 1979 |
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate.
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Aspartic Acid; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Glucose; Hypoxanthines; Inosine Nucleotides; Liver Neoplasms; Mengovirus; Neoplasm Proteins; Neoplasms, Experimental; Nitroso Compounds; Purine Nucleotides; Pyrimidine Nucleotides; RNA, Neoplasm; Succinates; Uracil Nucleotides; Uridine | 1976 |
Pharmacologic disposition of DL-alanosine in mice, rats, dogs, and monkeys.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Aspartic Acid; Carbon Dioxide; Cats; Cells, Cultured; Dogs; Female; Haplorhini; Intestine, Small; Kidney; Kinetics; Leukemia, Experimental; Liver; Lung; Male; Nitrosamines; Rats; Sodium; Temperature | 1977 |
Metabolites of alanosine, an antitumor antibiotic.
Topics: Alanine; Amines; Animals; Antibiotics, Antineoplastic; Blood Proteins; Decarboxylation; Hemoglobins; Malate Dehydrogenase; Male; Mice; Mitochondria; Neoplasms, Experimental; Nitrosamines; Oxidation-Reduction; RNA, Transfer | 1979 |
Determination of L-alanosine in plasma and urine by reversed-phase high-performance liquid chromatography of the Dns derivative.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Dansyl Compounds; Female; Humans; Male; Microchemistry; Nitrosamines; Rabbits | 1979 |
Inhibition of mouse molar tooth germ morphogenesis in organ culture by alanosine.
Topics: Adenine; Alanine; Animals; Mice; Mice, Inbred BALB C; Mitosis; Molar; Morphogenesis; Nitrosamines; Odontogenesis; Organ Culture Techniques; Tooth Germ | 1978 |
Decrease in fertility, fecundity, and egg size after feeding alanosine to Phormia regina.
Topics: Alanine; Animals; Diptera; Female; Fertility; Insect Control; Nitroso Compounds; Ovum | 1975 |
Increased tumor control rates in murine fibrosarcoma by combined therapy with L-alanosine and radiation.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Body Temperature; Combined Modality Therapy; Dose-Response Relationship, Drug; Fibrosarcoma; Ketamine; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Radiation-Sensitizing Agents | 1989 |
Imbalance of purine nucleotides in alanosine-resistant baby hamster kidney cells.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Kinase; Adenylosuccinate Lyase; Adenylosuccinate Synthase; Alanine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; Culture Media; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphotransferases; Purines; Selection, Genetic; Transformation, Genetic; Uridine | 1989 |
Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.
Topics: Alanine; Animals; Cell Line; Chromatography, High Pressure Liquid; Deoxyadenine Nucleotides; Deoxyribonucleotides; Didanosine; Dideoxynucleotides; HIV; Inosine; Nucleotides; T-Lymphocytes | 1987 |
Cell growth and division in relation to differentiation of mouse erythroleukemia cells.
Topics: Alanine; Animals; Cell Differentiation; Cell Division; Cell Line; Cycloheximide; Friend murine leukemia virus; Hydrogen-Ion Concentration; Leukemia, Erythroblastic, Acute; Mice; Mycophenolic Acid; Protein Biosynthesis; RNA, Ribosomal | 1988 |
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Drug Evaluation; Female; Humans; Isoxazoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oxazoles; Thiadiazoles; Vinblastine | 1988 |
Alterations in nucleotide pools induced by 3-deazaadenosine and related compounds. Role of adenylate deaminase.
Topics: Adenine; Adenosine Kinase; Alanine; Aminoglycosides; AMP Deaminase; Animals; Anti-Bacterial Agents; Cell Survival; Coformycin; Hypoxanthine; Hypoxanthines; Mice; Nucleotide Deaminases; Nucleotides; Time Factors; Tubercidin | 1988 |
Induction of adenine salvage in mouse cell lines deficient in adenine phosphoribosyltransferase.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Alanine; Animals; Azaserine; Cell Line; Cross Reactions; Drug Resistance; Gene Expression Regulation; Karyotyping; Mice; Mycoplasma; Pentosyltransferases | 1985 |
L-alanosine: a noncooperative substrate for Escherichia coli aspartate transcarbamylase.
Topics: Alanine; Antibiotics, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbon Radioisotopes; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Molecular Conformation; Radioisotope Dilution Technique; Substrate Specificity | 1985 |
Contragestational profile of the tumor-inhibiting agent, L-alanosine, in the rat and the hamster.
Topics: Adenine; Alanine; Animals; Antibiotics, Antineoplastic; Aspartic Acid; Cell Division; Cricetinae; Dose-Response Relationship, Drug; Female; Fertility; Mesocricetus; Pregnancy; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Synthesis of adenosine nucleotides from hypoxanthine by human malaria parasites (Plasmodium falciparum) in continuous erythrocyte culture: inhibition by hadacidin but not alanosine.
Topics: Adenosine Triphosphate; Adenylosuccinate Synthase; Alanine; Animals; Erythrocytes; Glycine; Humans; Hypoxanthines; Plasmodium falciparum; Purine Nucleotides | 1984 |
Effect of L-alanosine on immune response.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Antibody Formation; Cells, Cultured; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Erythrocytes; Female; Hypersensitivity, Delayed; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Neoplasms, Experimental; Sheep; Spleen | 1984 |
Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias.
Topics: Alanine; Animals; Asparaginase; Doxorubicin; Drug Resistance; Leukemia, Experimental; Male; Mice; Vincristine | 1984 |
Phase II evaluation of L-alanosine (NSC-153353) for patients with disseminated malignant melanoma.
Topics: Alanine; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Skin Neoplasms | 1984 |
Differential effects of inhibitors of purine metabolism on two trichomonad species.
Topics: Alanine; Animals; Chromatography, High Pressure Liquid; Formycins; Glycine; Mycophenolic Acid; Purine Nucleotides; Purines; Pyrimidine Nucleosides; Species Specificity; Toyocamycin; Trichomonas vaginalis; Tritrichomonas; Tubercidin; Vidarabine | 1984 |
Purine de novo synthesis in liver and developing rat brain, and the effect of some inhibitors of purine nucleotide interconversion.
Topics: Aging; Alanine; Allopurinol; Animals; Animals, Newborn; Anti-Bacterial Agents; Azaserine; Brain; Female; Fetus; Liver; Male; Pregnancy; Purine Nucleotides; Purines; Rats; Rats, Inbred Strains; Ribavirin; Ribonucleosides | 1983 |
Phase II clinical trial of L-alanosine in advanced upper aerodigestive cancer.
Topics: Alanine; Carcinoma, Squamous Cell; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Leukopenia; Male; Stomatitis; Thrombocytopenia | 1983 |
The treatment of acute leukemia with continuous infusion L-Alanosine.
Topics: Acute Disease; Adolescent; Adult; Aged; Alanine; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Infusions, Parenteral; Leukemia; Male; Middle Aged | 1983 |
Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells.
Topics: Adenine; Adenosine; Alanine; Animals; Antimetabolites, Antineoplastic; Cell Division; DNA Replication; Guanine; Kinetics; Lymphoma; Methylthioinosine; Mice; Mycophenolic Acid | 1984 |
Phase I study of L-alanosine (NSC 15353).
Topics: Adult; Aged; Alanine; Antibiotics, Antineoplastic; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Stomatitis | 1983 |
A phase II study of alanosine in advanced large bowel carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Alanine; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation; Female; Humans; Male; Middle Aged; Nausea; Rectal Neoplasms; Stomatitis | 1983 |
A Phase I study of the combination N-(phosphonacetyl)-L-aspartate (PALA, NSC-224131) and L-alanosine (NSC-153353) in patients with advanced cancer.
Topics: Alanine; Aspartic Acid; Diarrhea; Digestive System Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Humans; Injections, Intravenous; Organophosphorus Compounds; Phosphonoacetic Acid; Stomatitis | 1983 |
Modulation of fluoropyrimidine metabolism in L1210 cells by L-alanosine.
Topics: Adenine; Alanine; Animals; Aspartic Acid; Cells, Cultured; Clone Cells; Deoxyuridine; Leukemia L1210; Mice; Nucleotides; Pyrimidines; Time Factors | 1983 |
Phase I study of L-alanosine using a daily x 3 schedule.
Topics: Adult; Aged; Alanine; Antibiotics, Antineoplastic; Drug Evaluation; Female; Hematopoiesis; Humans; Male; Middle Aged | 1982 |
Enzymatic release of nitric oxide from L-alanosine, an antineoplastic antibiotic.
Topics: Alanine; Amino Acid Oxidoreductases; Animals; Antibiotics, Antineoplastic; Biotransformation; Free Radicals; In Vitro Techniques; L-Amino Acid Oxidase; Models, Chemical; Nitric Oxide | 1982 |
Studies on the mechanism of resistance of selected murine tumors to L-alanosine.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibiotics, Antineoplastic; DNA; Drug Resistance; Leukemia L1210; Leukemia P388; Male; Mice; Neoplasms, Experimental; Nerve Tissue Proteins; Nitrosamines; Peptide Synthases; Succinates | 1981 |
Binding of copper and zinc by the antitumour agent L-alanosine.
Topics: Alanine; Animals; Chelating Agents; Copper; Humans; Lethal Dose 50; Leukemia P388; Male; Mice; Neoplasms; Nitrosamines; Rabbits; Superoxide Dismutase; Zinc | 1981 |
Uptake of 14C-labeled dicarboxylic amino acids in hepatocytes and hepatoma cells.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Amino Acids, Dicarboxylic; Aminoisobutyric Acids; Animals; Antibiotics, Antineoplastic; Aspartic Acid; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Phosphonoacetic Acid; Rats; Sodium | 1981 |
Determinants of the toxicity of L-alanosine to various organs of the mouse.
Topics: Adenylosuccinate Lyase; Adenylosuccinate Synthase; Alanine; Animals; Antibiotics, Antineoplastic; Male; Mice; Organ Specificity; Peptide Synthases; Tissue Distribution | 1981 |
Interaction of L-alanosine (NSC 153, 353) with enzymes metabolizing L-aspartic acid, L-glutamic acid and their amides.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Animals; Antineoplastic Agents; Aspartic Acid; Biological Transport, Active; DNA; Glutamates; Inosine Monophosphate; Liver; Male; Mice; Nitrosamines | 1980 |
A novel synergistic effect of alanosine and guanine on adenine nucleotide synthesis in mammalian cells. Alanosine as a useful probe for investigating purine nucleotide metabolism.
Topics: Adenine; Adenine Nucleotides; Adenylosuccinate Synthase; Alanine; Animals; Cell Division; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Female; Guanine; Humans; Nitrosamines; Ovary; Purine Nucleotides | 1980 |
Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase.
Topics: Adenylosuccinate Synthase; Alanine; Animals; Antibiotics, Antineoplastic; Biotransformation; DNA, Neoplasm; Ligases; Mice; Neoplasms, Experimental; Nitrosamines; Purines; Ribonucleotides | 1980 |
Biochemical effect of three different inhibitors of purine/pyrimidine metabolism on differentiation in HL60 cells.
Topics: Alanine; Cell Differentiation; Cell Division; Formates; Hematopoiesis; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine Monophosphate; Isoxazoles; Leukemia, Myeloid; Mycophenolic Acid; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Reactive Oxygen Species; Tumor Cells, Cultured | 1995 |
Cytosolic biosynthesis of GTP and ATP in normal rat pancreatic islets.
Topics: Adenosine Triphosphate; Alanine; Animals; Cytosol; Guanosine Triphosphate; Insulin; Islets of Langerhans; Male; Mercaptopurine; Mycophenolic Acid; Rats; Rats, Sprague-Dawley | 1995 |
Adenylosuccinate synthetase: a dominant amplifiable genetic marker in mammalian cells.
Topics: Adenylosuccinate Synthase; Alanine; Animals; Cell Line; Cell Separation; Cell Survival; Cricetinae; Cricetulus; Gene Amplification; Gene Transfer Techniques; Genes, Dominant; Genetic Markers; Transformation, Genetic | 1994 |
High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants.
Topics: Adenylosuccinate Synthase; Alanine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Hypoxanthine; Hypoxanthines; Inosine; Inosine Monophosphate; Meiosis; Mercaptopurine; Mice; Mycophenolic Acid; Oocytes; Purine-Nucleoside Phosphorylase; Purines; Uric Acid; Xanthine Oxidase | 1994 |
Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells.
Topics: Alanine; Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; DNA, Complementary; Gene Expression; Glycine; Glycoproteins; Molecular Sequence Data; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Oncogene Proteins; PC12 Cells; Phosphonoacetic Acid; RNA, Messenger; Symporters | 1993 |
Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells. Molecular cloning of a cDNA encoding the "non-muscle" isozyme.
Topics: Adenylosuccinate Synthase; Alanine; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Consensus Sequence; DNA Primers; Drug Resistance; Gene Amplification; Genes; Humans; Isoenzymes; Liver; Molecular Sequence Data; Muscles; Sequence Alignment; Sequence Homology, Amino Acid; Tissue Distribution | 1994 |
Purine deoxynucleoside metabolism in human melanoma cells with a high spontaneous mutation rate.
Topics: Alanine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Survival; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxyribonucleotides; HeLa Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Inosine; Magnetic Resonance Spectroscopy; Melanoma; Mutation; Ribavirin; Thioguanine; Tumor Cells, Cultured | 1996 |
ATP depletion affects NPM translocation and exportation of rRNA from nuclei.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Alanine; Antibiotics, Antineoplastic; Azides; Cell Nucleus; Dinitrophenols; HeLa Cells; Humans; Kinetics; Mycophenolic Acid; Nuclear Proteins; Nucleolus Organizer Region; Nucleophosmin; Ribosomes; RNA, Ribosomal; Sodium Azide | 1996 |
Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy.
Topics: Adenosine Monophosphate; Alanine; Antimetabolites, Antineoplastic; Chromosomes, Human, Pair 9; DNA Mutational Analysis; DNA, Neoplasm; Exons; Genes; Genes, Tumor Suppressor; Humans; Leukemia-Lymphoma, Adult T-Cell; Methionine; Neoplasm Proteins; Polymerase Chain Reaction; Purine-Nucleoside Phosphorylase; Sequence Deletion; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Adenine nucleotide metabolism in primary rat neuronal cultures.
Topics: Adenine Nucleotides; Alanine; Animals; Cells, Cultured; Cellular Senescence; Homeostasis; Neurons; Purines; Rats | 1996 |
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
Topics: Alanine; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Feasibility Studies; Genetic Vectors; Humans; Lung Neoplasms; Methionine; Methotrexate; Neoplasm Proteins; Purine-Nucleoside Phosphorylase; Purines; Tetrahydrofolates; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies.
Topics: Alanine; Antibiotics, Antineoplastic; Cell Division; Colony-Forming Units Assay; Deoxyadenosines; Drug Design; Hematopoietic Stem Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Purine-Nucleoside Phosphorylase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1997 |
Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro.
Topics: Adenosine Monophosphate; Alanine; Antibiotics, Antineoplastic; Humans; Leukemia-Lymphoma, Adult T-Cell; Polymerase Chain Reaction; Purine-Nucleoside Phosphorylase; Thymidine | 1999 |
Modeling ischemia in vitro: selective depletion of adenine and guanine nucleotide pools.
Topics: Adenosine Triphosphate; Alanine; Animals; Antibiotics, Antineoplastic; Antimycin A; Apoptosis; Cell Hypoxia; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Guanosine; Guanosine Triphosphate; Ischemia; Kidney Cortex; Kidney Tubules, Proximal; LLC-PK1 Cells; Male; Models, Biological; Mycophenolic Acid; Necrosis; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Swine | 2000 |
Identification of gene expression profiles predicting tumor cell response to L-alanosine.
Topics: Alanine; Antibiotics, Antineoplastic; Cell Division; Cluster Analysis; Drug Resistance, Multiple; Gene Expression Profiling; HL-60 Cells; Humans; Tumor Suppressor Protein p53 | 2003 |
Determination of derivatized l-alanosine in plasma by liquid chromatography-tandem mass spectrometry.
Topics: Alanine; Antibiotics, Antineoplastic; Antineoplastic Agents; Chromatography, Ion Exchange; Mass Spectrometry; Sensitivity and Specificity | 2004 |
Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.
Topics: Alanine; Antibiotics, Antineoplastic; DNA, Complementary; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Methylthioinosine; Purine-Nucleoside Phosphorylase; Sarcoma; Transfection; Tumor Cells, Cultured | 2004 |
MTAP homozygous deletion: an Achilles heel of human cancers ready for clinical use?
Topics: Adenosine Monophosphate; Alanine; Antibiotics, Antineoplastic; Clinical Trials as Topic; Drug Resistance, Neoplasm; Gene Deletion; Homozygote; Humans; Neoplasms; Purine-Nucleoside Phosphorylase | 2005 |
EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine.
Topics: Adenine; Alanine; Antibiotics, Antineoplastic; Cell Line, Tumor; Deoxyadenosines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Erythroid Precursor Cells; Furans; Granulocyte Precursor Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Purine-Nucleoside Phosphorylase; Salvage Therapy; Thionucleosides | 2006 |
T-state active site of aspartate transcarbamylase: crystal structure of the carbamyl phosphate and L-alanosine ligated enzyme.
Topics: Alanine; Aspartate Carbamoyltransferase; Binding Sites; Carbamyl Phosphate; Crystallization; Crystallography, X-Ray; Escherichia coli; Ligands; Protein Structure, Tertiary | 2006 |
Circadian pharmacology of L-alanosine (SDX-102) in mice.
Topics: Alanine; Animals; Antineoplastic Agents; Body Weight; Bone Marrow; Chronotherapy; Darkness; Gene Expression; Hemorrhage; Intestines; Leukemia P388; Light; Liver; Lymphopenia; Male; Mice; Neutropenia; Purine-Nucleoside Phosphorylase; Treatment Outcome | 2006 |
Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro.
Topics: Alanine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Cattle; Cell Nucleus; Colforsin; Cyclic AMP; Enzyme Activation; Female; Hypoglycemic Agents; Meiosis; Metformin; Multienzyme Complexes; Mycophenolic Acid; Oocytes; Protein Serine-Threonine Kinases; Protein Subunits; Ribonucleotides | 2007 |
Genome-scale analysis of anti-metabolite directed strain engineering.
Topics: Alanine; Algorithms; Antimetabolites; Asparagine; Aspartic Acid; Cloning, Molecular; Contig Mapping; Escherichia coli; Gene Expression Profiling; Gene Frequency; Genetic Engineering; Genome, Bacterial; Genomic Library; Genomics; Lac Operon; Mutagenesis, Insertional; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phenotype; Plasmids; Selection, Genetic | 2008 |
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity.
Topics: Alanine; Animals; Azaserine; Cell Line, Tumor; Cell Survival; Diazooxonorleucine; Dose-Response Relationship, Drug; Fluorouracil; Methotrexate; Nucleic Acid Synthesis Inhibitors; Purines; Thioinosine; Thionucleotides; Uracil Nucleotides | 1981 |
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
Topics: Alanine; Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Cyclin D1; Down-Regulation; Female; Fibrosarcoma; Heterografts; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, SCID; Middle Aged; Molecular Targeted Therapy; Purine-Nucleoside Phosphorylase; Survival Analysis | 2014 |
The l-Alanosine Gene Cluster Encodes a Pathway for Diazeniumdiolate Biosynthesis.
Topics: Alanine; Azo Compounds; Bacterial Proteins; Biosynthetic Pathways; Molecular Structure; Multigene Family; Streptomyces | 2020 |
Biosynthesis of the N-N-Bond-Containing Compound l-Alanosine.
Topics: Alanine; Aspartic Acid; Glutamic Acid; Molecular Structure; Multigene Family; Streptomyces | 2020 |