alanine and adenosine

alanine has been researched along with adenosine in 90 studies

Research

Studies (90)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (18.89)	18.7374
1990's	12 (13.33)	18.2507
2000's	15 (16.67)	29.6817
2010's	11 (12.22)	24.3611
2020's	35 (38.89)	2.80

Authors

Authors	Studies
Ensign, JC; Hirsch, CF	2
Gollakota, KG; Ram, BP; Rana, RS	1
Cheung, WY; Lynch, TJ; Tallant, EA	1
Shimizu, H; Yamamura, Y	1
Ensign, JC; Grund, AD	1
Aronson, AI; Fitz-James, PC	1
Yousten, AA	1
Barnini, S; Batoni, G; Capaccioli, A; Cercignani, G; Freer, G; Senesi, S	1
Doi, M; Hayashi, N; In, Y; Inoue, M; Ishida, T; Mitsunaga, J; Shoku, Y; Ueda, H	1
Adam, R; Bismuth, H; Capron-Laudereau, M; Dimicoli, JL; Lhoste, JM; Nedelec, JF; Patry, J	1
Bingham, H; Chan, VL; Du, RP; Juranka, P; Pang, JC	1
Isono, K; Osada, H	1
Buc, HA; Claeyssens, S; Lavoinne, A; Matray, F; Pinosa, M	1
Ichishita, H; Odagiri, H; Shimizu, H	1
Cochran, SA; Ordal, ZJ	1
Briones, R; Chagoya de Sánchez, V; Piña, E	1
Chen, SS; Duerre, JA; Walgate, JH	1
Fredholm, BB; Sandberg, G	1
El Sayed, YM; Nguyen, BT; Sadée, W	1
Akhondzadeh, S; Stone, TW	2
Adam, R; Astarcioglu, I; Bismuth, H; Dimicoli, JL; Gigou, M; Patry, J; Sebagh, M	1
Cardoso, LF; Martini, LH; Souza, DO; Tasca, CI; Vendite, D	1
Jacobson, KA; Jiang, Q; Kim, J; Van Rhee, AM; Wess, J; Yehle, S	1
Fabbri, E; Lucchi, R; Notari, S; Poli, A; Virgili, M	1
Beukers, MW; Dalpiaz, A; IJzerman, AP; Schofield, PR; Townsend-Nicholson, A	1
Clements, MO; Moir, A	1
Adam, R; Dimicoli, JL; Patry, J	1
Breitenbach, JM; Cheng, YC; Drach, JC; Geiser, F; Gullen, E; Hartline, CB; Kern, ER; Kira, T; Ptak, RG; Qiu, YL; Zemlicka, J	1
Bhagwat, AS; Sharath, AN; Weinhold, E	1
Clarke, S; Griffith, SC; Thapar, N; Yeates, TO	1
Fraser, ME; Joyce, MA; Ryan, DG; Wolodko, WT	1
Bryła, J; Derlacz, RA; Jagielski, AK; Jarzyna, R; Lietz, T; Winiarska, K; Wohner, D	1
Bagley, CJ; D'Andrea, RJ; Darrow, AL; Derian, CK; Moretti, PA; Pitson, SM; Qi, J; Vadas, MA; Wattenberg, BW; Zareie, R; Zebol, JR	1
Fuller, BJ; So, PW	1
Hohmeier, N; Lempka, M; Verspohl, EJ	1
Aoyama, Y; Hohsaka, T; Kanatani, K; Matsumoto, H; Sando, S; Sato, N	1
Bandur, N; Finking, R; Koert, U; Marahiel, MA; May, JJ; Weber, TT; Wiegeshoff, F	1
Remm, M; Tats, A; Tenson, T	1
Frerking, M; Partovi, D	1
Cuevas-Covarrubias, SA; Gonzalez-Huerta, LM; Messina-Baas, OM	1
Aoyama, Y; Kanatani, K; Sando, S	1
de Groot, H; Rauen, U; Wille, T	1
Micura, R; Steger, J	1
Dignam, JD; Garbett, NC; Griffith, WP; Guo, J; Holloway, A; Mueser, T	1
De Clercq, E	2
Boal, AK; Booker, SJ; Grove, TL; Schwalm, EL	1
Aurelio, L; Christopoulos, A; Gregory, KJ; May, LT; Nguyen, AT; Nguyen, TD; Scammells, PJ; Sexton, PM; Thomas, T; Vecchio, EA; White, PJ	1
Baltos, JA; Christopoulos, A; Gregory, KJ; May, LT; Muñoz, LL; Nguyen, AT; Nguyen, TD; Sexton, PM; Thomas, T; White, PJ	1
Bavari, S; Cardile, AP; Martins, KA; Reisler, RB; Warren, TK	1
Jochmans, D; Neyts, J	1
Babusis, D; Birkus, G; Cho, A; Eng, S; Fenaux, M; Feng, JY; Kirschberg, T; Park, Y; Ray, AS; Tirunagari, N; Voitenleitner, C; Wang, T; Xu, Y; Yang, H	1
Feng, JY; Götte, M; Porter, DP; Tchesnokov, EP	1
Du, B; Kang, HYJ; Li, XY; Qiu, HB; Sun, B; Tong, ZH; Wang, F; Wang, YS; Zhan, X	1
Alvarez, JC; Annane, D; Etting, I; Larabi, IA; Moine, P	1
Carvalho Junior, RN; J C Neto, AM; Martins, AY; Reis, AF; S Costa, JF; Silva Arouche, TD	1
Bunel, V; Descamps, D; Jaquet, P; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH	1
Bunel, V; Descamps, D; Jaquet, P; Le Beller, C; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH	1
Muller, FL; Yan, VC	1
Cies, JJ; Davis, MR; Pham, CU	1
Arnold, L; Chernobrovkin, A; Friman, T; Martinez Molina, D	1
Chen, YS; Chu, J; German, P; Humeniuk, R; John Ling, KH; Mathias, A; Tarnowski, T; van Ingen, E; Xiao, D	1
Brügel, M; Habler, K; Liebchen, U; Paal, M; Scharf, C; Schönermarck, U; Teupser, D; Vogeser, M	1
Bojkova, D; Buyck, C; Ciesek, S; Cinatl, J; De Jonghe, S; De Meyer, S; Jochmans, D; Leyssen, P; Neyts, J; Van Damme, E; Van Loock, M	1
Celik, I; Duzgun, Z; Erol, M	1
Babusis, D; Cao, H; German, P; Humeniuk, R; Kirby, BJ; Ling, J; Lutz, JD; Mathias, A; Osinusi, A; Porter, D; Reddy, YS; Wei, X	1
Gandhi, M; Gerona, R; Metcalfe, J; Ong, CM; Reckers, A; Wu, AHB	1
Daftarian, PM; George, MV; Kleiman, E; Magcase, D; Mao, B; Sierra, G	1
Abe, T; Maekawa, M; Mano, N; Sato, T; Yamaguchi, H	1
Deb, S; Reeves, AA	1
Elfiky, AA; Elshemey, WM; Ibrahim, IM; Ibrahim, MN; Mahran, HA; Sonousi, A	1
Bode-Böger, SM; Hoeper, MM; Kielstein, JT; Martens-Lobenhoffer, J; Schmidt, JJ	1
Beadle, JR; Carlin, AF; Clark, AE; Garretson, AF; Hostetler, KY; Leibel, SL; McMillan, RE; McVicar, RN; Murphy, J; Schooley, RT; Smith, VI; Valiaeva, N; Xie, J; Zhang, XQ	1
Hansen, PE; Hansen, PR; Jürgens, G; Rasmussen, HB; Taboureau, O; Thomsen, R; Zeth, K	1
Assis, LC; da Cunha, EFF; de Almeida La Porta, F; de Castro Ramalho, T; de Castro, AA; de Jesus, JPA; Kuca, K; Nepovimova, E	1
Cho, JY; Choe, PG; Han, SS; Jeong, SI; Kang, CK; Kim, DK; Kim, NJ; Lee, S; Lee, SM; Oh, MD; Park, WB; Yang, L	1
Hamada, S; Hirai, T; Imoto, E; Ito, I; Itohara, K; Kai, S; Katada, Y; Matsumura, K; Nakagawa, T; Ohtsuru, S; Sato, Y; Sukeishi, A; Tanabe, N; Terada, T; Yanagita, M; Yonezawa, A	1
Green, DJ; Imburgia, CE; Kelley, WE; Mcknite, AM; Reilly, CA; Rower, JE; Watt, KM	1
Beadle, JR; Chatterjee, P; Flint, M; Hostetler, KY; Lo, MK; Montgomery, JM; Murphy, J; Schooley, RT; Shrivastava-Ranjan, P; Spiropoulou, CF; Valiaeva, N	1
Aukland, MH; Brunen, S; Grossmann, O; Leutzsch, M; List, B; Mitschke, B; Obradors, C; Schwengers, SA	1
Defant, A; Dosi, F; Innocenti, N; Mancini, I	1
André, E; Chiu, W; De Jonghe, S; Jochmans, D; Leyssen, P; Maes, P; Neyts, J; Raymenants, J; Slechten, B; Vangeel, L	1
Antonia, S; Aregay, M; Barlow, ML; Beg, AA; Boyle, TA; Castro, J; Chen, DT; Chen, Z; Chiappori, AA; Creelan, B; Gray, JE; Haura, EB; Hurtado, FK; Manenti, L; Morgan, L; Morris, E; Tanvetyanon, T; Thapa, R	1
Babusis, D; Bannister, R; Baric, RS; Barrett, KT; Bilello, JP; Bleier, BJ; Brown, AJ; Chun, K; Cihlar, T; Conrad, WS; Dong, S; Du Pont, V; Feng, JY; Gully, KL; Kalla, R; Mackman, RL; Martinez, DR; May, SR; Meganck, RM; Montgomery, SA; Moreira, FR; Murakami, E; Schäfer, A; Sheahan, TP; Subramanian, R; Tang, J; Won, JJ; Zweigart, MR	1
Bilello, JP; Camus, G; Cihlar, T; Du Pont, V; Kurhade, C; Li, J; Lu, X; Maiorova, E; Manhas, S; Martin, R; Mo, H; Perry, JK; Pitts, J; Porter, DP; Riola, N; Rodriguez, L; Shi, PY; Xie, X	1
Bosma, LBE; Leegwater, E; Moes, DJAR; Ottens, TH; van der Meer, IM; van Nieuwkoop, C; Wilms, EB	1
Agrati, C; Ascoli Bartoli, T; Benvenuto, D; Marchioni, L; Nicastri, E; Stazi, GV; Tempestilli, M	1
Vatandaslar, H	1

Reviews

7 review(s) available for alanine and adenosine

Article	Year
C-Nucleosides To Be Revisited. Journal of medicinal chemistry, 2016, Mar-24, Volume: 59, Issue:6 Topics: Adenine; Adenosine; Alanine; Animals; Antineoplastic Agents; Antiviral Agents; Humans; Nucleosides; Nucleotides; Pseudouridine; Purine Nucleosides; Pyrrolidines; Triazines	2016
Will There Be a Cure for Ebola? Annual review of pharmacology and toxicology, 2017, 01-06, Volume: 57 Topics: Adenine; Adenosine; Adenosine Monophosphate; Africa, Western; Alanine; Animals; Antiviral Agents; Disease Outbreaks; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Purine Nucleosides; Pyrrolidines; Ribonucleotides	2017
The path towards effective antivirals against rabies. Vaccine, 2019, 08-02, Volume: 37, Issue:33 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Drug Repositioning; Humans; Post-Exposure Prophylaxis; Pyrazines; Pyrrolidines; Rabies; Rabies virus	2019
New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections. Chemistry, an Asian journal, 2019, Nov-18, Volume: 14, Issue:22 Topics: Adenine; Adenosine; Alanine; Amides; Antiviral Agents; Base Pairing; Ebolavirus; Guanine; Hemorrhagic Fevers, Viral; Humans; Nucleotides; Phosphoric Acids; Pyrazines; Triazines	2019
[Pharmacotherapeutics for the new coronavirus pneumonia]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2020, Mar-12, Volume: 43, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antiviral Agents; China; Coronavirus Infections; COVID-19; Cytochrome P-450 CYP3A Inhibitors; Drug Therapy, Combination; Humans; Lopinavir; Pneumonia, Viral; Retrospective Studies; Ribonucleotides; Ritonavir	2020
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor. Clinical pharmacokinetics, 2021, Volume: 60, Issue:5 Topics: Adenosine; Adenosine Monophosphate; Adult; Alanine; Animals; Antiviral Agents; Area Under Curve; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Drug Interactions; Furans; Half-Life; Humans; Metabolic Clearance Rate; Pyrroles; SARS-CoV-2; Triazines	2021
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19. Viruses, 2021, 07-14, Volume: 13, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Humans; Phosphorylation; Prodrugs; SARS-CoV-2	2021

Trials

1 trial(s) available for alanine and adenosine

Article	Year
Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 06-01, Volume: 28, Issue:11 Topics: Adenosine; Alanine; Antibodies, Monoclonal, Humanized; Aspartate Aminotransferases; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Purinergic P1 Receptor Antagonists; Tumor Microenvironment	2022

Article

Year

Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 06-01, Volume: 28, Issue:11

Topics: Adenosine; Alanine; Antibodies, Monoclonal, Humanized; Aspartate Aminotransferases; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Purinergic P1 Receptor Antagonists; Tumor Microenvironment

2022

Other Studies

82 other study(ies) available for alanine and adenosine

Article	Year
Nutritionally defined conditions for germination of Streptomyces viridochromogenes spores. Journal of bacteriology, 1976, Volume: 126, Issue:1 Topics: Adenosine; Alanine; Aminobenzoates; Calcium; Carbon Dioxide; Culture Media; Glucose; Glutamates; Hydrogen-Ion Concentration; Magnesium; Saccharomyces cerevisiae; Spores, Bacterial; Stereoisomerism; Streptomyces; Temperature	1976
Heat activation of Streptomyces viridochromogenes spores. Journal of bacteriology, 1976, Volume: 126, Issue:1 Topics: Adenosine; Alanine; Aminobenzoates; Calcium; Culture Media; Glutamates; Hot Temperature; Hydrogen-Ion Concentration; Magnesium; Spores, Bacterial; Stereoisomerism; Streptomyces; Time Factors	1976
Inhibition of germination of Bacillus cereus T spores by phenylglyoxal. Folia microbiologica, 1979, Volume: 24, Issue:3 Topics: Adenosine; Alanine; Aldehydes; Bacillus cereus; Culture Media; Glyoxal; Picolinic Acids; Spores, Bacterial	1979
Brevibacterium liquefaciens adenylate cyclase and its in vivo stimulation by pyruvate. Journal of bacteriology, 1975, Volume: 124, Issue:3 Topics: Adenosine; Adenylyl Cyclases; Alanine; Brevibacterium; Cell Membrane; Cyclic AMP; Glucose; Phosphoric Diester Hydrolases; Pyruvates; Stereoisomerism; Stimulation, Chemical	1975
Effects of diaminopropionate, deoxyadenosine, and theophylline on stimulated formation of cyclic AMP and GMP by depolarizing agents in slices of guinea-pig cerebral cortex. Journal of neurochemistry, 1977, Volume: 28, Issue:2 Topics: Adenosine; Alanine; Amino Acids, Diamino; Animals; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Cysteine; Deoxyadenosines; Glutamates; Guinea Pigs; Histamine; In Vitro Techniques; Male; Nucleotides, Cyclic; Ouabain; Potassium; Theophylline; Veratridine; Xanthines	1977
Role of carbon dioxide in germination of spores of Streptomyces viridochromogenes. Archives of microbiology, 1978, Sep-01, Volume: 118, Issue:3 Topics: Adenosine; Alanine; Carbon Dioxide; Citric Acid Cycle; Culture Media; Oxaloacetates; Spores, Bacterial; Streptomyces	1978
Properties of Bacillus cereus spore coat mutants. Journal of bacteriology, 1975, Volume: 123, Issue:1 Topics: Adenosine; Alanine; Bacillus cereus; Bacterial Proteins; Freeze Etching; Muramidase; Mutation; Peptides; Phenotype; Spores, Bacterial	1975
Germination of Bacillus cereus endospores: a proposed role for heat shock and nucleosides. Canadian journal of microbiology, 1975, Volume: 21, Issue:8 Topics: Adenosine; Alanine; Alanine Racemase; Bacillus cereus; Hot Temperature; Inosine; Nucleosides; Spores, Bacterial; Stereoisomerism; Time Factors	1975
Role of spore coats in the germinative response of Bacillus cereus to adenosine and its analogues. Canadian journal of microbiology, 1992, Volume: 38, Issue:1 Topics: Adenosine; Alanine; Bacillus cereus; Cell Membrane; Spores, Bacterial	1992
X-ray crystallographic conformational study of 5'-O-[N-(L-alanyl)-sulfamoyl]adenosine, a substrate analogue for alanyl-tRNA synthetase. Biochimica et biophysica acta, 1991, Oct-25, Volume: 1080, Issue:2 Topics: Adenosine; Alanine; Alanine-tRNA Ligase; Hydrogen Bonding; Indicators and Reagents; Models, Molecular; Molecular Conformation; Molecular Structure; Substrate Specificity; X-Ray Diffraction	1991
Mouse liver metabolism after 24-hour and 48-hour cold preservation using UW, hydroxyethyl starch-free UW, and Euro-Collins solutions: A 31P, 13C NMR spectroscopy and biochemical analysis. Transplantation proceedings, 1990, Volume: 22, Issue:2 Topics: Adenosine; Adenosine Triphosphate; Alanine; Allopurinol; Animals; Carbon Isotopes; Gluconeogenesis; Glucose; Glutathione; Hypertonic Solutions; Insulin; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Organ Preservation; Organ Preservation Solutions; Perfusion; Phosphorus; Raffinose; Solutions	1990
Imbalance of purine nucleotides in alanosine-resistant baby hamster kidney cells. Somatic cell and molecular genetics, 1989, Volume: 15, Issue:2 Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Kinase; Adenylosuccinate Lyase; Adenylosuccinate Synthase; Alanine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; Culture Media; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphotransferases; Purines; Selection, Genetic; Transformation, Genetic; Uridine	1989
Mechanism of action and selective toxicity of ascamycin, a nucleoside antibiotic. Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Alanine; Anti-Bacterial Agents; Bacteria; Bacterial Proteins; DNA, Bacterial; Escherichia coli; Microbial Sensitivity Tests; Peptide Biosynthesis; Peptides; Poly U; RNA, Bacterial; Xanthomonas	1985
The mechanism by which adenosine decreases gluconeogenesis from lactate in isolated rat hepatocytes. The Biochemical journal, 1987, Sep-01, Volume: 246, Issue:2 Topics: Adenine Nucleotides; Adenosine; Alanine; Animals; Cyclic AMP; Gluconeogenesis; In Vitro Techniques; Ketone Bodies; Lactates; Lactic Acid; Liver; Phosphates; Pyruvates; Pyruvic Acid; Rats	1987
Stimulated formation of cyclic adenosine 3':5'-monophosphate by aspartate and glutamate in cerebral cortical slices of guinea pig. The Journal of biological chemistry, 1974, Sep-25, Volume: 249, Issue:18 Topics: Adenine; Adenosine; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Calcium; Carbon Radioisotopes; Cerebral Cortex; Cocaine; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Glutamates; Guinea Pigs; Kinetics; Male; Phosphoric Diester Hydrolases; Stereoisomerism; Stimulation, Chemical; Structure-Activity Relationship; Theophylline	1974
Oxidative activation of Bacillus cereus spores. Applied microbiology, 1973, Volume: 25, Issue:2 Topics: Adenosine; Alanine; Bacillus cereus; Boric Acids; Food Microbiology; Hot Temperature; Inosine; Kinetics; Mercaptoethanol; Spores; Spores, Bacterial; Stereoisomerism; Stimulation, Chemical; Time Factors	1973
Inhibition by adenosine of the cortisol-induced liver glycogen accumulation in adrenalectomized rats. Biochemical pharmacology, 1971, Volume: 20, Issue:10 Topics: Adenosine; Adipose Tissue; Adrenalectomy; Alanine; Animals; Carbon Isotopes; Drug Antagonism; Glucose; Hydrocortisone; Lipids; Liver Glycogen; Male; Rats; Stimulation, Chemical	1971
Oxidative deamination of sulfur amino acids by bacterial and snake venom L-amino acid oxidase. Archives of biochemistry and biophysics, 1971, Volume: 146, Issue:1 Topics: Adenosine; Alanine; Amino Acid Oxidoreductases; Animals; Catalase; Cattle; Chromatography, Thin Layer; Cysteine; Cystine; Homocysteine; Homocystine; Hydrogen-Ion Concentration; Kinetics; Liver; Methionine; Models, Biological; Models, Structural; Oxygen Consumption; Proteus; S-Adenosylmethionine; Snakes; Species Specificity; Sulfides; Sulfur; Venoms	1971
Regulation of thymocyte proliferation: effects of L-alanine, adenosine and cyclic AMP in vitro. Thymus, 1981, Volume: 3, Issue:2 Topics: Adenosine; Adenosine Deaminase; Alanine; Animals; Cell Division; Cyclic AMP; Cyclopentanes; Guinea Pigs; Kinetics; Male; Mitosis; Pyrrolidinones; Rolipram; T-Lymphocytes; Theophylline	1981
Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells. Cancer research, 1984, Volume: 44, Issue:6 Topics: Adenine; Adenosine; Alanine; Animals; Antimetabolites, Antineoplastic; Cell Division; DNA Replication; Guanine; Kinetics; Lymphoma; Methylthioinosine; Mice; Mycophenolic Acid	1984
Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors. British journal of pharmacology, 1995, Volume: 115, Issue:3 Topics: Action Potentials; Adenosine; Alanine; Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Corpus Striatum; Culture Techniques; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Hippocampus; Male; Muscimol; Neuronal Plasticity; Pregnanediones; Pregnanolone; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA; Receptors, Metabotropic Glutamate; Valine	1995
Protective effect of alanine against graft failure of transplanted livers from fasted donor rats. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Alanine; Alanine Transaminase; Allopurinol; Analysis of Variance; Animals; Aspartate Aminotransferases; Fasting; Glutathione; Graft Survival; Insulin; L-Lactate Dehydrogenase; Liver Glycogen; Liver Transplantation; Male; Organ Preservation; Organ Preservation Solutions; Raffinose; Random Allocation; Rats; Rats, Inbred Lew	1995
Modulation of adenosine-induced cAMP accumulation via metabotropic glutamate receptors in chick optic tectum. Neurochemical research, 1995, Volume: 20, Issue:9 Topics: Adenosine; Alanine; Animals; Benzoates; Chickens; Cyclic AMP; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Quinoxalines; Receptors, Metabotropic Glutamate; Superior Colliculi	1995
Glutamate-independent long term depression in rat hippocampus by activation GABAA receptors. Life sciences, 1996, Volume: 58, Issue:13 Topics: 2-Amino-5-phosphonovalerate; Adenosine; Alanine; Animals; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Muscimol; Neuronal Plasticity; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A	1996
Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition. Molecular pharmacology, 1996, Volume: 50, Issue:3 Topics: Adenosine; Adenylyl Cyclases; Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Binding, Competitive; Cyclic AMP; GTP-Binding Proteins; Humans; Kinetics; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Polymerase Chain Reaction; Protein Structure, Secondary; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Recombinant Proteins; Ribose; Sequence Tagged Sites; Serine	1996
Neurochemical changes in cerebellum of goldfish exposed to various temperatures. Neurochemical research, 1997, Volume: 22, Issue:2 Topics: Acclimatization; Adenine Nucleotides; Adenosine; Alanine; Animals; Aspartic Acid; Cerebellum; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Goldfish; Kinetics; Potassium; Serine; Taurine; Temperature	1997
Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors. Biochemical pharmacology, 1998, Dec-01, Volume: 56, Issue:11 Topics: Adenosine; Alanine; Amino Acid Substitution; Animals; Binding, Competitive; CHO Cells; Cricetinae; Entropy; Humans; Kinetics; Point Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptors, Purinergic P1; Theophylline; Thermodynamics; Threonine; Transfection; Xanthines	1998
Role of the gerI operon of Bacillus cereus 569 in the response of spores to germinants. Journal of bacteriology, 1998, Volume: 180, Issue:24 Topics: Adenosine; Alanine; Amino Acid Sequence; Bacillus cereus; Base Sequence; Cloning, Molecular; DNA, Bacterial; Genes, Bacterial; Guanosine; Inosine; Molecular Sequence Data; Operon; Sequence Analysis, DNA; Spores, Bacterial	1998
The effect of dichloroacetate and alanine on the metabolic recovery of perfused mouse liver after cold ischemia. NMR in biomedicine, 1999, Volume: 12, Issue:6 Topics: Adenosine; Alanine; Allopurinol; Animals; Carbon Isotopes; Cold Temperature; Cryopreservation; Dichloroacetic Acid; Fasting; Glutamine; Glutathione; Insulin; Ischemia; Liver; Male; Mice; Nuclear Magnetic Resonance, Biomolecular; Organ Preservation; Organ Preservation Solutions; Phosphorus; Raffinose; Reperfusion Injury; Tissue Donors	1999
Synthesis and enantioselectivity of the antiviral effects of (R,Z)-,(S,Z)-methylenecyclopropane analogues of purine nucleosides and phosphoralaninate prodrugs: influence of heterocyclic base, type of virus and host cells. Antiviral chemistry & chemotherapy, 2000, Volume: 11, Issue:3 Topics: Adenosine; Alanine; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Cyclopropanes; Cytomegalovirus; Hepatitis B virus; Herpesviridae; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV-1; Humans; Molecular Structure; Prodrugs; Stereoisomerism; Virus Replication; Viruses	2000
Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue. Biochemistry, 2000, Nov-28, Volume: 39, Issue:47 Topics: Adenosine; Alanine; Cysteine; Cytosine; Deamination; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; Enzyme Inhibitors; Escherichia coli; Mutagenesis, Site-Directed; S-Adenosylmethionine; Serine; Uracil	2000
Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides. The Journal of biological chemistry, 2002, Jan-11, Volume: 277, Issue:2 Topics: Adenosine; Alanine; Archaeal Proteins; Deoxyadenosines; Enzyme Stability; Ethionine; Humans; Hydrogen-Ion Concentration; Methylation; Molecular Structure; Oligopeptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Pyrococcus furiosus; Recombinant Proteins; S-Adenosylhomocysteine; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Temperature; Thionucleosides	2002
Two glutamate residues, Glu 208 alpha and Glu 197 beta, are crucial for phosphorylation and dephosphorylation of the active-site histidine residue in succinyl-CoA synthetase. Biochemistry, 2002, Jan-15, Volume: 41, Issue:2 Topics: Adenosine; Alanine; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamic Acid; Histidine; Hydrogen Bonding; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Succinate-CoA Ligases; Time Factors	2002
Purinergic regulation of glucose and glutamine synthesis in isolated rabbit kidney-cortex tubules. Archives of biochemistry and biophysics, 2002, Aug-15, Volume: 404, Issue:2 Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Ammonium Chloride; Animals; Aspartic Acid; Calcium Signaling; Cyclic AMP; Dose-Response Relationship, Drug; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glutamine; Glycerol; Hypoxanthine; In Vitro Techniques; Inosine; Kidney Tubules; Ligands; Male; Phosphorylation; Pyruvic Acid; Rabbits; Signal Transduction	2002
The nucleotide-binding site of human sphingosine kinase 1. The Journal of biological chemistry, 2002, Dec-20, Volume: 277, Issue:51 Topics: Adenosine; Adenosine Triphosphate; Affinity Labels; Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Azides; Baculoviridae; Binding Sites; Blotting, Western; Calmodulin; Catalysis; Catalytic Domain; Cell Line; DNA, Complementary; Gene Deletion; Humans; Insecta; Kinetics; Lysine; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nucleotides; Phosphotransferases (Alcohol Group Acceptor); Photoaffinity Labels; Protein Binding; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Transfection	2002
Enhanced energy metabolism during cold hypoxic organ preservation: studies on rat liver after pyruvate supplementation. Cryobiology, 2003, Volume: 46, Issue:3 Topics: Adenosine; Adenosine Triphosphate; Alanine; Allopurinol; Animals; Cryopreservation; Dose-Response Relationship, Drug; Drug Combinations; Energy Metabolism; Glutathione; Insulin; Lactic Acid; Liver; Male; Organ Preservation Solutions; Osmolar Concentration; Pyruvic Acid; Raffinose; Rats; Rats, Sprague-Dawley; Succinic Acid	2003
Diadenosine tetraphosphate (Ap4A) induces a diabetogenic situation: its impact on blood glucose, plasma insulin, gluconeogenesis, glucose uptake and GLUT-4 transporters. Die Pharmazie, 2003, Volume: 58, Issue:12 Topics: 3T3 Cells; Adenosine; Adenosine Triphosphate; Adipocytes; Alanine; Animals; Blood Glucose; Blotting, Western; Cell Line, Tumor; Deoxyglucose; Diabetes Mellitus; Dinucleoside Phosphates; Epinephrine; Female; Glucagon; Gluconeogenesis; Glucose; Glucose Transporter Type 4; Hepatocytes; In Vitro Techniques; Insulin; Liver; Male; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Perfusion; Rats; Rats, Wistar; Vasoconstrictor Agents	2003
A small-molecule-based approach to sense codon-templated natural-unnatural hybrid peptides. Selective silencing and reassignment of the sense codon by orthogonal reacylation stalling at the single-codon level. Journal of the American Chemical Society, 2005, Jun-08, Volume: 127, Issue:22 Topics: Acylation; Adenosine; Alanine; Amino Acid Sequence; Codon; Escherichia coli; Gene Silencing; Molecular Sequence Data; Oligopeptides; Phenylalanine; Phenylalanine-tRNA Ligase; RNA, Messenger; RNA, Transfer, Amino Acyl; Tetrahydrofolate Dehydrogenase	2005
Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall. The FEBS journal, 2005, Volume: 272, Issue:12 Topics: Adenosine; Alanine; Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Base Sequence; Carbon-Oxygen Ligases; Carrier Proteins; Cell Wall; Cloning, Molecular; Drug Resistance, Bacterial; Enzyme Inhibitors; Escherichia coli Proteins; Growth Inhibitors; Microbial Sensitivity Tests; Molecular Sequence Data; Protein Processing, Post-Translational; Substrate Specificity; Transferases; Transferases (Other Substituted Phosphate Groups); Vancomycin	2005
Highly expressed proteins have an increased frequency of alanine in the second amino acid position. BMC genomics, 2006, Feb-16, Volume: 7 Topics: Adenosine; Alanine; Animals; Codon; Escherichia coli; Gene Expression; Genome, Archaeal; Genome, Bacterial; Genomics; Nucleotides; Open Reading Frames; Peptide Chain Initiation, Translational; Proteins; Sequence Analysis, Protein	2006
Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors. Neuropharmacology, 2006, Volume: 51, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Alanine; Animals; Baclofen; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Agonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Naphthalenes; Neuromuscular Depolarizing Agents; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Kainic Acid; Receptors, Presynaptic; Thymine	2006
Two affected siblings with nuclear cataract associated with a novel missense mutation in the CRYGD gene. Molecular vision, 2006, Aug-24, Volume: 12 Topics: Adenosine; Adult; Alanine; Amino Acid Substitution; Case-Control Studies; Cataract; Cytosine; Female; gamma-Crystallins; Glutamic Acid; Haplotypes; Heterozygote; Humans; Lens Nucleus, Crystalline; Male; Microsatellite Repeats; Mutation, Missense; Pedigree	2006
A simple approach to sense codon-templated synthesis of natural/unnatural hybrid peptides. Nucleic acids symposium series (2004), 2005, Issue:49 Topics: Adenosine; Alanine; Base Sequence; Codon; Enzyme Inhibitors; Molecular Sequence Data; Naphthalenes; Peptides; Phenylalanine; Phenylalanine-tRNA Ligase; Protein Biosynthesis; Protein Engineering; RNA, Transfer, Phe; Templates, Genetic; Tetrahydrofolate Dehydrogenase	2005
Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments. Journal of vascular surgery, 2008, Volume: 47, Issue:2 Topics: Adenosine; Alanine; Allopurinol; Animals; Aorta; Aspartic Acid; Buffers; Cell Survival; Citrates; Cold Temperature; Deferoxamine; Endothelial Cells; Glucose; Glutathione; Glycine; Histidine; Hydrogen-Ion Concentration; Insulin; Iron; Iron Chelating Agents; Mannitol; Membrane Potential, Mitochondrial; Mitochondria; Organ Preservation; Organ Preservation Solutions; Platelet Adhesiveness; Potassium Chloride; Procaine; Raffinose; Rewarming; Swine; Time Factors	2008
Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs. Bioorganic & medicinal chemistry, 2011, Sep-01, Volume: 19, Issue:17 Topics: Adenosine; Alanine; Glycine; Hydrolysis; Isoleucine; Peptides; Polystyrenes; Ribosomes; RNA; RNA, Transfer, Amino Acyl; Solid-Phase Synthesis Techniques	2011
Allosteric interaction of nucleotides and tRNA(ala) with E. coli alanyl-tRNA synthetase. Biochemistry, 2011, Nov-15, Volume: 50, Issue:45 Topics: Adenosine; Adenosine Triphosphate; Alanine; Alanine-tRNA Ligase; Allosteric Site; Amino Acid Sequence; Bacterial Proteins; Dimerization; Escherichia coli; Models, Molecular; Molecular Sequence Data; Protein Structure, Quaternary; Recombinant Proteins; RNA, Transfer, Ala; Thermodynamics	2011
Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA. Science (New York, N.Y.), 2016, Apr-15, Volume: 352, Issue:6283 Topics: Adenosine; Alanine; Amino Acid Substitution; Anticodon; Catalytic Domain; Crystallography, X-Ray; Cysteine; Escherichia coli Proteins; Methylation; Methyltransferases; Nucleic Acid Conformation; Protein Structure, Tertiary; RNA, Bacterial; RNA, Transfer, Glu; S-Adenosylmethionine	2016
Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity. Molecular pharmacology, 2016, Volume: 90, Issue:6 Topics: Adenosine; Alanine; Allosteric Regulation; Allosteric Site; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Humans; Ligands; Molecular Dynamics Simulation; Mutation; Protein Structure, Secondary; Receptor, Adenosine A1; Signal Transduction; Structural Homology, Protein; Structure-Activity Relationship	2016
Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy. Molecular pharmacology, 2016, Volume: 90, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Alanine; Amino Acid Substitution; Animals; Binding Sites; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Humans; Ligands; Molecular Dynamics Simulation; Mutant Proteins; Protein Structure, Secondary; Receptor, Adenosine A1; Structural Homology, Protein; Structure-Activity Relationship; Xanthines	2016
Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:8 Topics: Adenosine; Administration, Oral; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Cells, Cultured; Dogs; Hepacivirus; Hepatitis C; Humans; Male; Nucleotides; Prodrugs; Rats; Triazines; Virus Replication	2018
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir. Viruses, 2019, 04-04, Volume: 11, Issue:4 Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Antiviral Agents; DNA-Directed RNA Polymerases; Ebolavirus; Enzyme Inhibitors; Humans; Kinetics; Molecular Structure; Prodrugs; Respiratory Syncytial Virus, Human; Ribonucleotides; RNA-Dependent RNA Polymerase; RNA, Viral; Substrate Specificity; Viral Proteins	2019
Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient. Clinical chemistry and laboratory medicine, 2020, 08-27, Volume: 58, Issue:9 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chromatography, Liquid; Coronavirus Infections; COVID-19; Drug Monitoring; Drug Stability; Female; Furans; Humans; Limit of Detection; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pyrroles; Reproducibility of Results; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2020
Interactions Between Remdesivir, Ribavirin, Favipiravir, Galidesivir, Hydroxychloroquine and Chloroquine with Fragment Molecular of the COVID-19 Main Protease with Inhibitor N3 Complex (PDB ID:6LU7) Using Molecular Docking. Journal of nanoscience and nanotechnology, 2020, 12-01, Volume: 20, Issue:12 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Binding Sites; Chloroquine; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cysteine Endopeptidases; Drug Interactions; Humans; Hydrogen Bonding; Hydroxychloroquine; Ligands; Molecular Docking Simulation; Nanotechnology; Pandemics; Pneumonia, Viral; Protease Inhibitors; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Static Electricity; Viral Nonstructural Proteins	2020
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19. Antimicrobial agents and chemotherapy, 2020, 10-20, Volume: 64, Issue:11 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; beta-Cyclodextrins; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Interactions; Furans; Humans; Intensive Care Units; Lung Transplantation; Multiple Organ Failure; Pandemics; Pneumonia, Viral; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity". Antimicrobial agents and chemotherapy, 2020, 11-17, Volume: 64, Issue:12 Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung Transplantation; Neuroglia; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity. Antimicrobial agents and chemotherapy, 2020, 11-17, Volume: 64, Issue:12 Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on haemodialysis. The Journal of antimicrobial chemotherapy, 2021, 02-11, Volume: 76, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Furans; Humans; Kidney Failure, Chronic; Pyrroles; Renal Dialysis; Triazines	2021
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target. SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; ATPases Associated with Diverse Cellular Activities; Cell Cycle Proteins; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; Furans; Hep G2 Cells; Humans; Mass Spectrometry; Proteomics; Pyrroles; Triazines; United States; United States Food and Drug Administration	2021
Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies. Analytical biochemistry, 2021, 03-15, Volume: 617 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, High Pressure Liquid; COVID-19 Drug Treatment; Drug Monitoring; Furans; Humans; Limit of Detection; Pyrroles; Tandem Mass Spectrometry; Triazines	2021
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum Journal of pharmaceutical and biomedical analysis, 2021, Mar-20, Volume: 196 Topics: Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Chloroquine; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Furans; Humans; Hydroxychloroquine; Isotopes; Lopinavir; Pandemics; Pyrazines; Pyrroles; Ritonavir; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2021
In vitro activity of itraconazole against SARS-CoV-2. Journal of medical virology, 2021, Volume: 93, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Repositioning; Furans; Humans; Itraconazole; Pyrroles; SARS-CoV-2; Triazines; Vero Cells; Virus Replication	2021
In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase. Molecular diversity, 2022, Volume: 26, Issue:1 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Pyrazines; Pyrrolidines; Ribavirin; RNA, Viral; SARS-CoV-2	2022
A combined assay for quantifying remdesivir and its metabolite, along with dexamethasone, in serum. The Journal of antimicrobial chemotherapy, 2021, 06-18, Volume: 76, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, Liquid; COVID-19 Drug Treatment; Dexamethasone; Furans; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2021
Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells. Scientific reports, 2021, 05-05, Volume: 11, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Alanine; CD8-Positive T-Lymphocytes; Cell Proliferation; Humans; Immunologic Memory; T-Lymphocytes	2021
Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2021, Volume: 24 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Dogs; Dose-Response Relationship, Drug; Drug Approval; Furans; Humans; Kidney; Kidney Tubules, Proximal; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Pyrroles; Triazines	2021
Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2021, Volume: 24 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Computer Simulation; COVID-19; COVID-19 Drug Treatment; Databases, Chemical; Drug Interactions; Furans; Humans; Prodrugs; Pyrroles; Risk Assessment; Risk Factors; SARS-CoV-2; Triazines	2021
Novel adenosine derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective. Pharmacological reports : PR, 2021, Volume: 73, Issue:6 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Binding Sites; Computer Simulation; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Drug Design; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; SARS-CoV-2	2021
Pharmacokinetics of Remdesivir and GS-441524 during PIRRT and Seraph 100 Therapy. Clinical journal of the American Society of Nephrology : CJASN, 2021, Volume: 16, Issue:8 Topics: Adenosine; Adenosine Monophosphate; Adult; Aged; Alanine; COVID-19 Drug Treatment; Female; Hemofiltration; Humans; Intermittent Renal Replacement Therapy; Male; SARS-CoV-2	2021
Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs. Antimicrobial agents and chemotherapy, 2021, 09-17, Volume: 65, Issue:10 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; COVID-19 Drug Treatment; Cricetinae; Humans; Lipids; Prodrugs; SARS-CoV-2	2021
Effect of drug metabolism in the treatment of SARS-CoV-2 from an entirely computational perspective. Scientific reports, 2021, 10-07, Volume: 11, Issue:1 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Design; Drug Discovery; Humans; Metabolic Networks and Pathways; Molecular Docking Simulation; Nitro Compounds; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Thiazoles	2021
Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series. Clinical and translational science, 2022, Volume: 15, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Kidney; Renal Replacement Therapy	2022
Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction. CPT: pharmacometrics & systems pharmacology, 2022, Volume: 11, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Body Surface Area; COVID-19; COVID-19 Drug Treatment; Drug Administration Schedule; Extracorporeal Membrane Oxygenation; Female; Glomerular Filtration Rate; Humans; Japan; Kidney Diseases; Male; Middle Aged; Monte Carlo Method; Precision Medicine; Retrospective Studies	2022
Remdesivir and GS-441524 Extraction by Ex Vivo Extracorporeal Life Support Circuits. ASAIO journal (American Society for Artificial Internal Organs : 1992), 2022, 09-01, Volume: 68, Issue:9 Topics: Adenosine; Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; Extracorporeal Membrane Oxygenation; Humans; Renal Replacement Therapy	2022
Broad-Spectrum Microbiology spectrum, 2021, 12-22, Volume: 9, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Glyceryl Ethers; Humans; Lipids; Nucleosides; Prodrugs; SARS-CoV-2	2021
Direct and Catalytic C-Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside. Angewandte Chemie (International ed. in English), 2022, 03-07, Volume: 61, Issue:11 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Catalysis; Chemistry Techniques, Synthetic; COVID-19 Drug Treatment; Cyclization; Glycosylation; Humans; Models, Molecular; Nucleosides; Stereoisomerism; Time Factors	2022
Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibitors. International journal of molecular sciences, 2022, Jan-04, Volume: 23, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Cellulose; Computational Biology; Coronavirus RNA-Dependent RNA Polymerase; Molecular Docking Simulation; Molecular Dynamics Simulation; Nucleosides; Pyrolysis; SARS-CoV-2	2022
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern. Antiviral research, 2022, Volume: 198 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Microbial Sensitivity Tests; Nitriles; Proline; RNA-Dependent RNA Polymerase; SARS-CoV-2; Vero Cells; Virus Replication	2022
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice. Science translational medicine, 2022, 05-04, Volume: 14, Issue:643 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus Infections; COVID-19 Drug Treatment; Humans; Mice; Nucleosides; Parents; Prodrugs; SARS-CoV-2	2022
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants. Antimicrobial agents and chemotherapy, 2022, 06-21, Volume: 66, Issue:6 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2	2022
Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients. Antimicrobial agents and chemotherapy, 2022, 06-21, Volume: 66, Issue:6 Topics: Adenosine; Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; COVID-19 Drug Treatment; Critical Illness; Furans; Humans; Monte Carlo Method; Triazines	2022
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjects. The Journal of antimicrobial chemotherapy, 2022, 09-30, Volume: 77, Issue:10 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Transaminases; Triazines	2022
A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA Polymerase. International journal of molecular sciences, 2022, Jul-27, Volume: 23, Issue:15 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Nucleotides; Pandemics; RNA, Viral; SARS-CoV-2	2022