alanine has been researched along with adenosine monophosphate in 1097 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (2.73) | 18.7374 |
| 1990's | 10 (0.91) | 18.2507 |
| 2000's | 12 (1.09) | 29.6817 |
| 2010's | 25 (2.28) | 24.3611 |
| 2020's | 1020 (92.98) | 2.80 |
| Authors | Studies |
|---|---|
| Kesbeke, F; Thillart, G; Waarde, A | 1 |
| Gest, H; Johansson, BC | 1 |
| Paecht-Horowitz, M | 2 |
| Rao, NA; Seethalakshmi, S | 1 |
| Graff, JC; Plagemann, PG | 1 |
| Armstrong, DW; Fendler, JH; Saburi, M; Sequin, R | 1 |
| Goodman, MN; Lowenstein, JM | 1 |
| Choe, HW; Grunert, HP; Hahn, U; Heinemann, U; Koellner, G; Saenger, W; Zouni, A | 1 |
| Brunie, S; Ghosh, G; Pelka, H; Schulman, LH | 1 |
| Hägele, H; Weicker, H | 1 |
| Kimura, K; Kobayashi, H; Matsuoka, K | 1 |
| Jasin, M; Regan, L; Schimmel, P | 1 |
| Baquer, NZ; Srivastava, LK | 1 |
| Baron, P; Griffaton, G; Lowy, R | 2 |
| Bryce, GF | 1 |
| Deuel, TF; Prusiner, S | 1 |
| Kingdon, HS | 1 |
| Hachimori, A; Ito, M; Samejima, T | 1 |
| Oppenheim, B; Patchornik, A | 1 |
| Horecker, RL; Melloni, E; Pontremoli, S; Sia, CL; Traniello, S | 1 |
| Das, S; Marshall, FD; Skaper, SD | 1 |
| Deuel, TF; Turner, DC | 1 |
| Segal, A; Stadtman, ER | 1 |
| Hashimoto, T; Miyazawa, S; Sakurai, T; Shindo, Y | 1 |
| Hanson, RW; Jomain-Baum, M; Ogata, K | 1 |
| Hill, LJ; Martin, WG | 1 |
| Bernlohr, RW; Donohue, TJ | 1 |
| Platt, E; Robson, B | 1 |
| Cooney, DA; Jayaram, HN; Johnson, RK; Swiniarski, JK; Tyagi, AK | 1 |
| Giroux, EL; Kantrowitz, ER; Lu, G; Williams, MK | 1 |
| Aureli, T; Conti, F; Di Cocco, ME; Ghirardi, O; Giuliani, A; Miccheli, A; Ramacci, MT | 1 |
| Oliveira, CR; Rego, AC; Santos, MS | 1 |
| Buchbinder, JL; Fletterick, RJ | 1 |
| Batova, A; Bridgeman, L; Diccianni, MB; Nobori, T; Vu, T; Yu, AL; Yu, J | 1 |
| Aquaro, S; Balzarini, J; De Clercq, E; Heijtink, R; Kruining, J; McGuigan, C; Naesens, L; Pannecouque, C; Perno, CF; Wedgwood, O; Witvrouw, M | 1 |
| Amylon, MD; Batova, A; Bridgeman, LJ; Carrera, CJ; Diccianni, MB; Kung, FH; Omura-Minamisawa, M; Pullen, J; Yu, AL; Yu, J | 1 |
| Choe, JY; Fromm, HJ; Honzatko, RB; Nelson, SW | 1 |
| Luo, L; Walsh, CT | 1 |
| Blanchard, JS; Zheng, R | 1 |
| Brosius, JL; Colman, RF | 1 |
| Hua, S; Inesi, G; Lewis, D; Ma, H; Toyoshima, C | 1 |
| Bryła, J; Derlacz, RA; Jagielski, AK; Jarzyna, R; Lietz, T; Winiarska, K; Wohner, D | 1 |
| Beauvallet, C; Blanquet, S; Dessen, P; Hountondji, C; Lazennec, C; Pernollet, JC; Plateau, P | 1 |
| GOLDSTEIN, J; HOLLEY, RW | 1 |
| KUBY, SA; OLSON, OE | 1 |
| Caldas, C; Capella, G | 1 |
| Dang, Q; Erion, MD; Jiang, T; Kasibhatla, SR; Lipscomb, WN; Potter, SC; Reddy, KR; Reddy, MR; van Poelje, PD | 1 |
| Kim, G; Levine, RL; Luo, S | 1 |
| Schwer, B; Shuman, S; Wang, LK | 1 |
| Bae, E; Bingman, CA; Lee, JE; Phillips, GN; Raines, RT | 1 |
| Drozak, J; Stroobant, V; Van Schaftingen, E; Veiga-da-Cunha, M; Vertommen, D | 1 |
| Beckman, J; Konigsberg, WH; Wang, J; Xia, S | 1 |
| Boll, B; Heide, L; Herbst, DA; Stehle, T; Zocher, G | 1 |
| Jacewicz, A; Remus, BS; Shuman, S | 1 |
| Babusis, D; Bannister, R; Barauskas, O; Bavari, S; Braun, MR; Carra, E; Chen, SS; Chun, K; Cihlar, T; Clarke, MO; Doerffler, E; Donnelly, G; Eaton, BP; Fearns, R; Feng, JY; Flint, M; Garza, NL; Gharaibeh, D; Gomba, L; Grimes, E; Hui, HC; Jordan, R; Kenny, T; Kugelman, JR; Larson, N; Lee, WA; Lew, W; Lo, MK; Mackman, RL; Mayers, DL; McMullan, LK; Nagle, ER; Neville, S; Nichol, ST; Nichols, DK; Nuss, JE; Palacios, G; Park, Y; Perron, M; Ray, AS; Retterer, CJ; Ross, B; Shurtleff, AC; Siegel, D; Soloveva, V; Spiropoulou, CF; Stray, KM; Strickley, R; Stuthman, KS; Swaminathan, S; Trancheva, I; Van Tongeren, SA; Wang, Q; Warren, TK; Welch, LS; Wells, J; Wilhelmsen, CL; Wolfe, L; Wong, P; Xu, Y; Zamani, R; Zhang, L | 1 |
| Bell, DJ; Bhagani, S; Cropley, I; Filipe, A; Gifford, RJ; Gopal, R; Hopkins, S; Hughes, J; Jabeen, F; Jacobs, M; Johannessen, I; Karageorgopoulos, D; Lackenby, A; Lester, R; Liu, RS; MacConnachie, A; Mahungu, T; Marshall, N; Martin, D; Mepham, S; Orton, R; Palmarini, M; Patel, M; Perry, C; Peters, SE; Porter, D; Ritchie, D; Ritchie, ND; Rodger, A; Seaton, RA; Sreenu, VB; Templeton, K; Thomson, EC; Warren, S; Wilkie, GS; Zambon, M | 1 |
| Faull, K; Hwang, L; Ibba, M; Moghal, A | 1 |
| Bavari, S; Cardile, AP; Martins, KA; Reisler, RB; Warren, TK | 1 |
| Antierens, A; Burzio, C; Caluwaerts, S; De Clerck, H; Dörnemann, J; Kolié, MC; McElroy, AK; Ronsse, A; Sprecher, A; Van Herp, M; Yosifiva, V | 1 |
| Bannister, R; Barauskas, O; Bavari, S; Carra, E; Chun, K; Cihlar, T; Clarke, MO; Doerffler, E; Feng, JY; Hui, HC; Jordan, R; Knox, J; Lee, G; Lee, WA; Lew, W; Lo, MK; Mackman, RL; Neville, S; Perron, M; Perry, J; Ray, AS; Rheingold, AL; Ross, B; Siegel, D; Soloveva, V; Stray, KM; Strickley, R; Swaminathan, S; Wang, Q; Warren, TK; Wolfe, L; Xu, Y; Zhang, L | 1 |
| Arvey, A; Cihlar, T; Clarke, MO; Flint, M; Hotard, AL; Hui, HC; Jordan, R; Lo, MK; Mackman, RL; McMullan, LK; Nichol, ST; Perron, M; Ray, AS; Shrivastava-Ranjan, P; Siegel, D; Spiropoulou, CF; Sudhamsu, J | 1 |
| Babusis, D; Bannister, R; Baric, RS; Case, JB; Cihlar, T; Clarke, MO; Denison, MR; Feng, JY; Graham, RL; Gralinski, LE; Jordan, R; Leist, SR; Mackman, RL; Menachery, VD; Palmiotti, CA; Park, Y; Pyrc, K; Ray, AS; Sheahan, TP; Siegel, D; Sims, AC; Spahn, JE; Trantcheva, I | 1 |
| Jochmans, D; Neyts, J | 1 |
| Goyal, S; Grover, A; Grover, S; Jamal, S; Kaur, J; Kumari, A; Pandey, B; Singh, A | 1 |
| Agostini, ML; Andres, EL; Baric, RS; Case, JB; Cihlar, T; Clarke, MO; Denison, MR; Feng, JY; Graham, RL; Jordan, R; Lu, X; Mackman, RL; Ray, AS; Sheahan, TP; Siegel, D; Sims, AC; Smith, EC | 1 |
| Check Hayden, E | 1 |
| Nakkazi, E | 1 |
| Adams, PL; Beigel, JH; El-Kamary, SS; Ince, WL; Krafft, A; Nam, HH; Sims, AC | 1 |
| Feng, JY; Götte, M; Porter, DP; Tchesnokov, EP | 1 |
| Bannister, R; Cihlar, T; Cronin, J; de Wit, E; Feldmann, F; Feldmann, H; Gary, JM; Jordan, R; Klena, JD; Lo, MK; Nichol, ST; Patel, NR; Spiropoulou, CF; Zaki, SR | 1 |
| Baric, RS; Brown, AJ; Cihlar, T; Denison, MR; Dinnon, KH; Feng, JY; Graham, RL; Sheahan, TP; Sims, AC; Won, JJ | 1 |
| Díaz-Sáez, L; Gray, D; Hunter, WN; McElroy, SP; Torrie, LS | 1 |
| Lucey, DR | 1 |
| Aboulhab, J; Ahuka, S; Albert, S; Ali, R; Barrett, K; Bonnett, T; Cahill, K; Camara, M; Cao, H; Cone, K; Coulibaly, S; Crozier, I; Davey, RT; Diaz, J; Dighero-Kemp, B; Dodd, LE; Duvenhage, M; Eckes, R; Gettinger, N; Grais, R; Hensley, L; Herpin, B; Higgs, E; Holman, W; Ibanda, A; Kojan, R; Lane, HC; Ledgerwood, J; Levine, AC; Lusakibanza Manzo, M; Mbala-Kingebeni, P; Moench, T; Mukadi, D; Mukumbayi, P; Mulangu, S; Muyembe-Tamfum, JJ; Nordwall, J; Nzolo, D; Pierson, J; Proffitt, C; Proschan, M; Sivahera, B; Sivapalasingam, S; Smolskis, M; Sow, Y; Teitelbaum, M; Tierney, J; Tshiani Mbaya, O; Tshomba Oloma, A; Vallée, D; Walker, R | 1 |
| Avadhanula, V; Bahl, J; Hixson, J; Kim, DK; Machado, AA; Piedra, FA; Piedra, PA; Qiu, X; Teng, MN | 1 |
| Babusis, D; Baric, RS; Bauer, L; Brown, AJ; Cihlar, T; Clarke, MO; Denison, MR; Feng, JY; Hogg, A; Jordan, R; Leist, SR; Montgomery, SA; Porter, D; Schäfer, A; Sellers, S; Sheahan, TP; Sims, AC; Spahn, JE; Won, J | 1 |
| Lu, H | 1 |
| Cao, R; Hu, Z; Liu, J; Shi, Z; Wang, M; Xiao, G; Xu, M; Yang, X; Zhang, L; Zhong, W | 1 |
| Cihlar, T; Cronin, J; de Wit, E; Feldmann, F; Feldmann, H; Jordan, R; Okumura, A; Scott, D; Thomas, T | 1 |
| Maxmen, A | 1 |
| Feng, JY; Gordon, CJ; Götte, M; Porter, DP; Tchesnokov, EP | 1 |
| Lu, X; Pan, B; Sun, P; Sun, W; Xu, C | 1 |
| Li, J; Qi, C; Shen, L; Wang, Y; Zhang, Q | 1 |
| Elfiky, AA | 1 |
| De Clercq, E; Li, G | 1 |
| Anderson, PO | 1 |
| Brouqui, P; Colson, P; Lagier, JC; Raoult, D; Rolain, JM | 1 |
| Chen, PL; Hsueh, PR; Huang, CT; Ko, WC; Lee, NY; Lee, PI; Rolain, JM | 1 |
| Dong, L; Gao, J; Hu, S | 1 |
| Martinez, MA | 2 |
| Du, B; Kang, HYJ; Li, XY; Qiu, HB; Sun, B; Tong, ZH; Wang, F; Wang, YS; Zhan, X | 1 |
| Hsueh, PR; Hsueh, SC; Ko, WC; Lai, CC; Liu, YH; Wang, CY; Wang, YH; Yen, MY | 1 |
| Duan, Y; Zhou, C; Zhu, HL | 1 |
| Carradori, S | 1 |
| Atluri, S; Hirsch, JA; Manchikanti, L | 1 |
| Cohen, J; Kupferschmidt, K | 2 |
| Dai, Y; Huang, S; Zhang, C; Zheng, F | 1 |
| Li, YN; Su, Y | 1 |
| Cohen, S; Corbett, R; Haczku, A; Hardin, K; Nguyen, MV; Pidcock, W; Sanville, B; Schivo, M; Sebat, C; Thompson, GR | 1 |
| Reina, J | 1 |
| Ceccarelli, F; Conti, F; Di Franco, M; Spinelli, FR | 1 |
| Chang, YL; Chen, MY; Lee, WS; Lu, CC | 1 |
| Chan, MCW; Chen, D; Cheung, PP; Choy, KT; Chu, DKW; Huang, X; Hui, KPY; Kaewpreedee, P; Peiris, M; Sia, SF; Wong, AY; Yen, HL | 1 |
| Agostini, ML; Baric, RS; Bluemling, GR; Brown, AJ; Chappell, JD; Denison, MR; Dinnon, KH; George, AS; Graham, RL; Harcourt, J; Hill, CS; Hughes, TM; Kolykhalov, AA; Leist, SR; Lu, X; Montgomery, SA; Natchus, MG; Painter, G; Pruijssers, AJ; Saindane, M; Schäfer, A; Sheahan, TP; Sims, AC; Stevens, LJ; Swanstrom, R; Tamin, A; Thornburg, NJ; Zhou, S | 1 |
| Barlow, A; Barlow, B; Claassen, CW; Heavner, JJ; Heavner, MS; Landolf, KM; Yeung, SYA | 1 |
| Ahmed, S; Asperges, E; Bernett, J; Brainard, DM; Cao, H; Castagna, A; Chelliah, D; Chen, D; Chihara, S; Childs, R; Chokkalingam, A; Cohen, SH; Cunningham, J; D'Arminio Monforte, A; Desai, P; DeZure, A; Diaz, G; Elboudwarej, E; Feldt, T; Flanigan, T; Gaggar, A; Green, G; Green, ML; Grein, J; Henne, I; Ismail, S; Kato, H; L'Her, E; Lapadula, G; Lescure, FX; Maeno, T; Majumder, S; Massari, M; Mera, R; Mora-Rillo, M; Mutoh, Y; Myers, RP; Nguyen, D; Nicastri, E; Oda, R; Ohmagari, N; Osinusi, AO; Quiros-Roldan, E; Redinski, J; Sellers, S; Shin, D; Studemeister, A; Tan, SK; Telep, L; Timbs, L; Verweij, E; Winterbourne, L; Yo, K; Zhao, Y; Zhong, L; Zoufaly, A | 1 |
| Cao, L; Gao, Y; Ge, J; Guddat, LW; Hu, T; Hua, T; Huang, Y; Li, J; Liu, F; Liu, Z; Lou, Z; Ming, Z; Rao, Z; Sun, Q; Wang, H; Wang, Q; Wang, T; Xu, W; Yan, L; Yang, H; Yang, X; Zhang, B; Zhang, L; Zhang, Y; Zhao, Y; Zheng, L; Zhu, C; Zhu, Y | 1 |
| Kirchdoerfer, RN | 1 |
| Bottega, A; da Rosa, TF; Foletto, VS; Hörner, A; Hörner, R; Serafin, MB | 1 |
| Belfer, JJ; Bondici, A; Dumkow, LE; Hillaker, E; Murad, H | 1 |
| Cutrell, JB; Jodlowski, TZ; Monogue, ML; Sanders, JM | 1 |
| Arora, N; Banerjee, AK | 1 |
| Avery, RK; Boyarsky, BJ; Durand, CM; Garonzik-Wang, JM; Getsin, SN; Jackson, KR; Kernodle, AB; Massie, AB; Po-Yu Chiang, T; Segev, DL; Van Pilsum Rasmussen, SE; Werbel, WA | 1 |
| Alvarez, K; Canard, B; Decroly, E; Eydoux, C; Ferron, F; Guillemot, JC; Le, NT; Peersen, O; Selisko, B; Shannon, A | 1 |
| Feng, JY; Gordon, CJ; Götte, M; Perry, JK; Porter, DP; Tchesnokov, EP; Woolner, E | 1 |
| Şimşek Yavuz, S; Ünal, S | 1 |
| Costanzo, M; De Giglio, MAR; Roviello, GN | 1 |
| Lal, A; Mishra, AK; Sahu, KK | 1 |
| Bergan, S; Elens, L; Hesselink, DA; Langman, LJ; Lemaitre, F; Moes, DJAR; Molinaro, M; Venkataramanan, R | 1 |
| Gangadaran, P; Jogalekar, MP; Veerabathini, A | 1 |
| Hsueh, PR; Jean, SS; Lee, PI | 1 |
| Goldgur, Y; Shuman, S; Unciuleac, MC | 1 |
| Al-Saffar, F; Cruz, D; Fan, A; Gaynor, P; Hsu, JJ; Kamath, M; Nsair, A | 1 |
| Aryal, D; Beane, A; Dondorp, AM; Hayat, M; Schultz, MJ | 1 |
| Ge, J; Li, H; Liu, Z | 1 |
| Aronson, JK; Ferner, RE | 1 |
| Beard, T; Cowan, M; Manning, TJ; Thomas-Richardson, J | 1 |
| Aaron, JG; Arcasoy, S; Aversa, MM; Benvenuto, LJ; Brown, RS; Cohen, DJ; Dadhania, DM; Dove, LM; Dube, GK; Emond, JC; Farr, MA; Husain, SA; Kapur, S; Kodiyanplakkal, RP; Miko, BA; Mohan, S; Pereira, MR; Ratner, LE; Rosenblatt, RE; Samstein, B; Satlin, M; Small, CB; Tsapepas, DS; Uriel, N; Verna, EC; Walsh, TJ | 1 |
| Ledford, H | 5 |
| Augustin, M; Hallek, M; Nitschmann, S | 2 |
| Alkindi, N; Mazer-Amirshahi, M; Mehta, N; Pourmand, A | 1 |
| Ahsan, W; Alhazmi, HA; Bratty, MA; Javed, S; Najmi, A | 1 |
| Ardura, M; Auletta, JJ; Dandoy, C; Hartley, D; Jaglowski, S; Lehmann, L | 1 |
| Kao, JH; Su, TH | 1 |
| Jeevaratnam, K | 1 |
| Chang, S; Gao, M; Jiang, H; Jiang, HW; Jiang, Y; Luan, X; Mao, C; Shen, DD; Shen, J; Shen, Q; Su, H; Tao, SC; Tian, G; Wang, X; Xie, YC; Xu, HE; Xu, Y; Yin, W; Zhang, S; Zhang, Y; Zhao, W; Zhou, F | 1 |
| Dai, J; Huang, J; Jiang, H; Li, C; Li, R; Li, X; Liu, B; Ma, Q; Pan, W; Shi, Y; Wang, Z; Xie, Y; Yang, Z; Zhao, J; Zheng, K | 1 |
| Antonucci, M; Avataneo, V; Cusato, J; D'Avolio, A; de Nicolò, A; di Perri, G; Lamorde, M; Manca, A; Palermiti, A; Waitt, C; Walimbwa, S | 1 |
| Delang, L; Neyts, J | 1 |
| Lapadula, G | 1 |
| Ballout, RA; Bukrinsky, MI; Remaley, AT; Sviridov, D | 1 |
| Fang, Y; Meng, XM; Ni, WJ; Shen, AZ; Xu, T; Zhou, H | 1 |
| Adebayo, AI; Adeoye, AO; Olaoye, IF; Oso, BJ; Tijjani, H | 1 |
| Cao, D; Li, C; Li, G; Li, Z; Sun, R; Wang, X | 1 |
| Baden, LR; Morrissey, S; Rubin, EJ | 6 |
| Kiessling, L; MacLaughlin, C; Sattin, S | 1 |
| Douedi, S; Miskoff, J | 1 |
| Coumou, J; de Vries, PJ | 1 |
| Hendaus, MA | 1 |
| Babadaei, MMN; Bloukh, SH; Falahati, M; Haghighat, S; Hasan, A; Kachooei, E; Sharifi, M; Vahdani, Y | 1 |
| Gadebusch Bondio, M; Marloth, M | 1 |
| Anastasiou, IA; Eleftheriadou, I; Tentolouris, A; Tentolouris, N; Tsilingiris, D | 1 |
| Yang, K | 1 |
| Baggett, MV; Rhee, EP; Shepard, JO; Sise, ME; Stevens, JS | 1 |
| Ferguson, J; Gumma, M; Kappagoda, S; Quintero, O; Rogers, A; Rosser, JI; Scott, J; Subramanian, A | 1 |
| Boucher, HW; Ison, MG; Wolfe, C | 1 |
| Aldrich, M; Cabana, MD; Chao, JY; Derespina, KR; Goldman, DL; Herold, BC; Medar, SS; Ushay, HM; Weingarten, J | 1 |
| Angeli, E; Antinori, S; Bonazzetti, C; Borghi, B; Castelli, A; Coen, M; Colombo, R; Corbellino, M; Cossu, MV; Galli, M; Giacomelli, A; Giorgi, R; Gismondo, MR; Gubertini, G; Magni, C; Meroni, L; Milazzo, L; Mileto, D; Oreni, L; Pagani, G; Pellicciotta, M; Rech, R; Ridolfo, AL; Rizzardini, G; Rusconi, S; Torre, A; Vimercati, S | 1 |
| Bonovas, S; Piovani, D | 1 |
| Fätkenheuer, G; Lundgren, J | 1 |
| Hoffmann, C | 1 |
| Lai, T; Wu, B; Wu, J | 1 |
| Brainard, D; Grein, J; Myers, RP | 1 |
| Berlin, DA; Gulick, RM; Martinez, FJ | 1 |
| Scudellari, M | 1 |
| Andini, R; Bertolino, L; Corcione, A; Durante-Mangoni, E; Florio, LL; Mele, F; Murino, P; Zampino, R | 1 |
| Jia, X; Kai, G; Li, L; Nile, A; Nile, SH; Qiu, J | 1 |
| Stuebe, A | 1 |
| Carugati, M; Castaldo, G; Faccioli, P; Franzetti, M; Iemoli, E; Longoni, E; Molteni, C; Ormas, V; Pandolfo, A; Piconi, S; Pozzetti, U | 1 |
| Estella, Á; Garnacho-Montero, J | 1 |
| Norrie, JD | 1 |
| Cao, B; Cao, L; Cheng, Z; Ding, D; Du, G; Du, R; Fan, G; Fu, S; Gao, L; Gu, X; Guo, T; Hayden, FG; Horby, PW; Hu, Y; Jaki, T; Jiang, Y; Jin, Y; Li, H; Liu, B; Liu, Z; Lu, Q; Lu, Y; Luo, G; Mei, C; Qin, H; Ruan, S; Shang, L; Tang, X; Wan, Y; Wang, A; Wang, C; Wang, K; Wang, S; Wang, Y; Wu, F; Xu, J; Yang, C; Yang, J; Ye, X; Ye, Y; Yin, W; Zhang, D; Zhang, Y; Zhao, J; Zhou, F | 1 |
| Marto, N; Monteiro, EC | 1 |
| Aggarwal, G; Aggarwal, S; Bangalore, S; Henry, BM | 1 |
| Cattaneo, D; Clementi, E; Corbellino, M; Galli, M; Gervasoni, C; Riva, A | 1 |
| Ahmad, SI | 1 |
| Cramer, P; Dienemann, C; Farnung, L; Hillen, HS; Kokic, G; Tegunov, D | 1 |
| Gottlieb, M; Hicks, C; Liang, SY; Long, B; Rosenberg, H | 1 |
| Bhattacharya, M; Chakraborty, C; Lee, SS; Saha, A; Sharma, AR; Sharma, G | 2 |
| Feldmann, H; Geisbert, TW; Sprecher, A | 1 |
| Atmar, RL; Babiker, AG; Beigel, JH; Benfield, T; Bonnett, T; Burgess, TH; Chu, HY; Creech, CB; Dierberg, K; Dodd, LE; Fätkenheuer, G; Finberg, RW; Green, M; Hohmann, E; Hsieh, L; Kalil, AC; Kline, S; Kortepeter, MG; Lane, HC; Lopez de Castilla, D; Luetkemeyer, A; Lundgren, J; Lye, DC; Makowski, M; Mehta, AK; Nayak, S; Neaton, JD; Oh, MD; Ohmagari, N; Osinusi, A; Paredes, R; Patterson, TF; Pett, S; Ruiz-Palacios, GM; Short, WR; Sweeney, DA; Tapson, V; Tomashek, KM; Touloumi, G; Zingman, BS | 1 |
| Atzrodt, CL; Clements, TP; Maknojia, I; McCarthy, RDP; Oldfield, TM; Po, J; Stepp, HE; Ta, KTL | 1 |
| Dresser, LD; Jorgensen, SCJ; Kebriaei, R | 1 |
| Cao, B; Cheng, Z; Du, G; Du, R; Fan, G; Fu, S; Gao, L; Hayden, FG; Horby, PW; Hu, Y; Jaki, T; Jin, Y; Liu, W; Liu, Y; Lu, Q; Lu, Y; Luo, G; Ruan, S; Wang, C; Wang, K; Wang, Y; Zhang, D; Zhang, Y; Zhao, J; Zhou, F | 1 |
| Arya, A; Dwivedi, VD | 1 |
| Sun, D | 1 |
| Cheng, B; Li, T | 1 |
| Dolin, R; Hirsch, MS | 1 |
| Ahn, MY; Blair, C; Brainard, DM; Bruno, R; Cao, H; Chen, YS; Diaz, G; Gaggar, A; Galli, M; Goldman, JD; Hui, DS; Hyland, RH; Lye, DCB; Marks, KM; Marty, FM; Montejano, R; Mullane, KM; Muñoz, J; Nahass, RG; Osinusi, AO; SenGupta, D; Spinner, CD; Subramanian, A; Tashima, KT; Towner, WJ; Wei, X | 1 |
| Davies, M; Dhanda, S; Evans, A; Lane, S; Osborne, V; Roy, D; Shakir, S | 1 |
| Jain, S; Jolly, T; Mansuri, Z; Shah, B; Zafar, MK | 1 |
| Bannister, R; Bavari, S; Bearss, J; Blair, C; Cihlar, T; Donnelly, G; Garza, N; Gomba, L; Jordan, R; Lee, E; Moreau, A; Porter, DP; Steffens, J; Van Tongeren, S; Warren, TK; Weidner, JM; Wells, J; Wetzel, K | 1 |
| Beh, DLL; Chew, N; Ngiam, JN; Poh, KK; Sia, CH | 1 |
| Beretta, P; Carnevale, S; Morbini, P | 1 |
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| Hadi, MA; Hasan, SS; Kow, CS; Thiruchelvam, K | 1 |
| Armstrong, LA; Beale, R; Bineva-Todd, G; Canal, B; Diffley, JFX; Drury, LS; Howell, M; Kulathu, Y; Labib, K; Lim, CT; Milligan, JC; O'Reilly, N; Ozono, E; Tan, KW; Ulferts, R; Weissmann, F; Wu, M; Zeisner, TU; Zeng, J | 1 |
| Basier, C; Basu, S; Beale, R; Canal, B; Cowling, VH; Curran, JF; Deegan, T; Diffley, JFX; Drury, LS; Fujisawa, R; Howell, M; Labib, K; Lim, CT; Mak, T; McClure, AW; Roberts, EL; Tan, KW; Ulferts, R; Weissmann, F; Wu, M; Zeisner, TU | 1 |
| Layton, AT; Sadria, M | 1 |
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| Aballi, S; Andersen, JT; Aukrust, P; Barratt-Due, A; Berg, Å; Blomberg, B; Dahl, TB; Dalgard, O; Dudman, S; Dyrhol-Riise, AM; Eiken, R; Ernst, G; Finbråten, AK; Fladeby, C; Hannula, R; Haugli, M; Heggelund, L; Hoel, H; Hoff, DAL; Holten, AR; Johannessen, A; Kåsine, T; Kildal, AB; Kittang, BR; Le, LAK; Lund-Johansen, F; Mathiessen, A; Mielnik, P; Müller, F; Nezvalova-Henriksen, K; Olsen, IC; Olsen, RB; Skåra, KH; Skei, NV; Skudal, H; Steffensen, A; Tholin, B; Thoresen, L; Tonby, K; Tran, T; Trøseid, M; Tveita, A; Ystrøm, CM | 1 |
| Abraham, GM; Andrews, R; Dunn, A; Etxeandia-Ikobaltzeta, I; Forciea, MA; Haeme, R; Humphrey, LL; Jokela, JA; Miller, MC; Qaseem, A; Tschanz, MP; Yost, J | 1 |
| Chao, CM; Hsueh, PR; Lai, CC | 1 |
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| Alexander, B; Beck, BF; Crothers, K; Kobayashi, T; Lund, BC; Miller, DR; Ohl, ME; Richardson Miell, K; Vaughan Sarrazin, MS | 1 |
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| Au, ICH; Cowling, BJ; Lau, EHY; Lau, KTK; Wong, CKH; Xiong, X | 1 |
| Argentieri, G; Bernasconi, E; Gianella, P; Grazioli-Gauthier, L; Vanini, G | 1 |
| Coogan, A; Duwe, I; Faltraco, F; Palm, D; Simon, F; Thome, J; Tucha, O; Uzoni, A | 1 |
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| de Vries, YA; Field, SM; Hoek, JM; Linde, M; Muradchanian, J; Pittelkow, MM; van Ravenzwaaij, D | 1 |
| Bode-Böger, SM; Hoeper, MM; Kielstein, JT; Martens-Lobenhoffer, J; Schmidt, JJ | 1 |
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| Choi, SH; Hwang, Y; Jo, YH | 1 |
| Busnadiego, I; Caflisch, A; Fernbach, S; Glas, I; Hale, BG; Hunziker, A; Marrafino, F; Moroz-Omori, EV; Pohl, MO; Stertz, S; Wiedmer, L | 1 |
| Arcuri, C; Aseri, M; Barve, P; Chaudhuri, S; Gupta, R; Kumar, S; Shah, S | 1 |
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| Aboumrad, M; Huizenga, H; Neupane, N; Riblet, N; Shiner, B; Young-Xu, Y | 1 |
| Kamath, A; Singh, A | 1 |
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| Carpenedo, R; Chinè, E; Dauri, M; Leonardis, F; Natoli, S; Vannicola, F | 1 |
| Kassab, H; Manickam, R; Mechineni, A | 1 |
| Ejima, K; Fujita, Y; Iwami, S; Iwanami, S; Kim, KS; Kuba, K; Miyazaki, T; Oda, T | 1 |
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| Dey, M; Singh, RK | 1 |
| Akash, MSH; Ashraf, T; Khosa, MK; Qureshi, QH; Rehman, K | 1 |
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| Bhatti, K; Chidurala, RM; Das, R; Mehta, DK; Rana, M; Saini, M | 1 |
| Chifiriuc, C; Manoliu, L; Mernea, M; Seiman, CD; Seiman, DD; Sogor, C; Speranta, A | 1 |
| Egorova, NN; Ishimaru, M; Iwagami, M; Kuno, T; Miyamoto, Y; Takahashi, M | 1 |
| Abdullah, N; Anderson, EJ; Anglin, O; Barney, G; Bennett, NM; Billing, L; Bye, E; Chatelain, R; Como-Sabetti, K; Eisenberg, N; Felsen, CB; Fry, AM; Garg, S; Hall, A; Havers, FP; Herlihy, R; Hill, M; Kawasaki, B; Kim, L; Kim, S; Kirley, PD; Maslar, A; Milucky, J; Monroe, ML; Muse, A; O'Halloran, A; Openo, KP; Patel, K; Pham, H; Reeg, L; Reingold, A; Ryan, PA; Schaffner, W; Shiltz, J; Shrum Davis, S; Sutton, M; Talbot, HK; Taylor, C; Teno, K; Weigel, A; Whitaker, M; Wortham, J; Yousey-Hindes, K | 1 |
| Bilello, J; Cihlar, T; Feng, J; Humeniuk, R; Li, L; Li, R; Mackman, R; Murakami, E; Osinusi, A; Porter, D | 1 |
| Hansen, PE; Hansen, PR; Jürgens, G; Rasmussen, HB; Taboureau, O; Thomsen, R; Zeth, K | 1 |
| Gauffin, O; Grundmark, B; Rocca, E; Savage, R; Vidlin, SH | 1 |
| Bibilik, MO; Bilgic, A; Gonen, MS; Jarrett, J; Keskindemirci, Y; Kutlubay, Z; Malhan, S; Oksuz, E; Ozcagli, G; Sahin, T; Tabak, F | 1 |
| Benson, CA; Davey, RT; Dodd, LE; Doernberg, SB; Gallagher, SK; Grossberg, R; Hynes, NA; Lye, DC; Paules, CI; Ponce, PO; Rapaka, RR; Short, WR; Voell, J; Wang, J; Wolfe, CR; Yang, OO | 1 |
| Khaheshi, I; Shahrbaf, MA; Tabary, M | 1 |
| Bartolini, D; Cruciani, G; Galli, F; Gioiello, A; Pistilli, A; Rende, M; Stabile, AM; Vacca, C | 1 |
| Deng, F; Ding, Q; Gan, T; Gao, H; Gong, M; Huang, W; Huang, Y; Li, Q; Nie, J; Rao, Y; Wang, Y; Wu, Y; Yang, Y; Zhang, R; Zhong, J | 1 |
| Chow, VT; Chu, JJH; Tan, KSW; Tan, YL | 1 |
| Bednar, P; Herout, V; Hrabovsky, S; Husa, P; Kabut, T; Kral, Z; Lengerova, M; Mayer, J; Pacasova, R; Prochazkova, J; Ruzek, D; Weinbergerova, B; Zdrazilova-Dubska, L | 1 |
| Afifi, N; Althani, A; Angelini, F; Caceci, T; Cenciarelli, C; Marei, HE; Pozzoli, G | 1 |
| Alexander, GC; An, H; Andersen, KM; Bates, B; Bennett, TD; Chute, CG; Garibaldi, BT; Joseph, C; Kocis, PT; Madhira, V; Mansour, O; Mehta, HB; Moffitt, R; Rashidi, ES; Setoguchi, S | 1 |
| Cornely, OA; Franz, J; Jakobs, F; Jeck, J; Kron, A; Kron, F | 1 |
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| Algren, H; Arguinchona, H; Berrington, WR; Chang, SC; Choi, R; Christensen, AB; Christensen, J; Cover, CJ; Cronenweth, C; Davila, J; Diaz, GA; Doherty, G; Echaiz, JF; Fee, M; Footer, B; French, T; Gluckman, T; Goldman, JD; Goulet, D; Grunkemeier, GL; Hadlock, J; Hammond, TC; Laurenson, C; Mackiewicz, J; Malkoski, S; Marfori, JE; Matson, MD; McClung, D; McKelvey, PA; Micikas, M; Mukkamala, Y; Pacifico, A; Parsons, GT; Pusch, T; Rai, E; Robicsek, A; Robinson, P; Roper, R; Rueda, J; Sarafian, F; Standaert, S; Tallman, GB; Tipton, R; Ward, BC | 1 |
| Bonnett, T; Dodd, LE; Fintzi, J; Frank, MG; Ganesan, A; Huprikar, NA; McLellan, SLF; Mehta, AK; Sweeney, DA; Tebas, P | 1 |
| Bendixsen Randall, T; Coones, JA; Dunay, MA; Holloway, RL; McClain, SL; Mohr, CE; Norris, SLW; Sasaki, BH; Vietri, NJ | 1 |
| Ascione, T; Conti, V; Filippelli, A; Franci, G; Pagliano, P; Piazza, O; Scarpati, G; Sellitto, C | 1 |
| Awano, N; Fujimoto, K; Inomata, M; Ito, Y; Izumo, T; Kuse, N; Matsumoto, H; Muto, Y; Saiki, A; Sakamoto, K; Takada, K; Tone, M | 1 |
| Alders, N; Bamford, A; Best, T; Boshier, FAT; Breuer, J; Bynoe, PD; Dalton, C; de Silva, TI; Frauenfelder, C; Goldstein, RA; Grandjean, L; Grunewald, S; Hatcher, J; Köeglmeier, J; Myerson, P; Pang, J; Parker, M; Penner, J; Roy, S; Williams, R | 1 |
| Berk, H; Demir Önder, K; Öztoprak, N; Seremet Keskin, A; Seyman, D | 1 |
| Au, ICH; Chung, MSH; Cowling, BJ; Lau, EHY; Lau, KTK; Wong, CKH; Xiong, X | 1 |
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| Barati, S; Dastan, A; Dastan, F; Fakharian, A; Haseli, S; Jamaati, H; Mirenayat, M; Rezaei, M; Torkaman, P; Yousefian, S | 1 |
| Davis, MR; Jorgensen, SCJ; Lapinsky, SE | 1 |
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| Ceccarelli, G; Celani, L; d'Ettorre, G; Lombardi, F; Mancone, M; Marazzato, M; Mastroianni, CM; Piccirilli, A; Pugliese, F; Trinchieri, V | 1 |
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| Arabi, M; Bitar, F; Eid, AH; Fakhri, G; Younis, NK; Zareef, RO | 1 |
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| Asakura, H; Hirai, K; Kanda, Y; Tsuji, K; Yamada, S | 1 |
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| Agüero, D; Albiach, L; Almuedo-Riera, A; Alonso, R; Ambrosioni, J; Bodro, M; Camon, AM; Cardozo, C; Castro, P; Chumbita, M; Cuesta, G; de la Mora, L; Del Rio, A; Dueñas, G; Garcia, F; Garcia-Pouton, N; Garcia-Vidal, C; Hernandez-Meneses, M; Herrera, S; Inciarte, A; Marcos, MA; Martínez, JA; Meira, F; Mensa, J; Morata, L; Muñoz, J; Nicolas, JM; Prieto-Gonzalez, S; Puerta-Alcalde, P; Sanjuan, G; Soriano, A; Tuset, M; Vila, J | 1 |
| Ching, PR; Lee, C | 1 |
| Adams, DH; Alatorre-Alexander, J; Cardoso, A; Chakladar, S; Crowe, B; de Bono, S; de Cassia Pellegrini, R; Ely, EW; Estrada, V; Goldman, JD; Kartman, CE; Krishnan, V; Liao, R; Marconi, VC; Piruzeli, MLB; Ramanan, AV; Reis, P; Som, M; Zhang, X | 1 |
| Brown, CE; Clement, FM; Congly, SE; Saxinger, L; Varughese, RA | 1 |
| Ambrus, C; Bakos, É; Özvegy-Laczka, C; Sarkadi, B; Telbisz, Á | 1 |
| Cherrington, NJ; Ekins, S; McGrath, ME; Miller, SR; Wright, SH; Zorn, KM | 2 |
| Brondeel, KC; Charipova, K; Cornett, EM; Erwin, A; Fox, CJ; Gress, KL; Kaye, AD; Kevil, CG; Knight, HE; Lerner, ZI; Urits, I; Urman, RD | 1 |
| Al-Sawalha, NA; Keewan, N; Slati, F; Taha, HR | 1 |
| Banerjee, A; Kanwar, M; Maiti, S | 1 |
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| Barzilay, R; Collins, JJ; Eastman, RT; Itkin, Z; Jaakkola, TS; Jin, W; Stokes, JM; Zakharov, AV | 1 |
| Anson, BJ; Ghosh, AK; Hattori, SI; Higashi-Kuwata, N; Lendy, EK; Mesecar, AD; Mitsuya, H; Raghavaiah, J; Shahabi, D; Yadav, M | 1 |
| da Silva Filipe, A; Furnon, W; Kohl, A; Lieber, G; MacLean, OA; Mair, D; Merits, A; Orton, RJ; Palmarini, M; Patel, AH; Pinto, RM; Stewart, ME; Suarez, NM; Szemiel, AM; Thomson, EC; Turnbull, ML; Wang, S; Wickenhagen, A; Willett, BJ; Wilson, SJ | 1 |
| Ader, F; Belhadi, D; Bouscambert-Duchamp, M; Burdet, C; Costagliola, D; Diallo, A; Greil, R; Guedj, J; Hites, M; Lê, MP; Mentré, F; Paiva, JA; Peiffer-Smadja, N; Peytavin, G; Poissy, J; Staub, T; Yazdanpanah, Y | 1 |
| Gyselinck, I; Janssens, W | 1 |
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| Azzam, EI; Jadhav, AB; Wang, Y; Yu, J | 1 |
| Hussar, DA | 1 |
| Basler, CF; Davey, RA; Edwards, MR; El-Sayed, NS; Jureka, AS; Keiser, PT; Lohan, S; Parang, K; Tiwari, RK; Totonchy, J; Williams, CG | 1 |
| Aisa, HA; Jiang, H; Li, J; Luan, X; Shang, W; Shen, J; Tian, G; Wang, Z; Xiao, G; Xie, Y; Xu, HE; Xu, Y; Yin, W; Zhang, L; Zhang, S; Zhang, Y | 1 |
| Apostolidou, S; Avataneo, V; Kobbe, R; Rau, C; Singer, D | 1 |
| Bannister, R; Bavari, S; Cihlar, T; Donnelly, G; Garza, NL; Gomba, L; Iversen, PL; Kane, CD; Norris, S; Porter, DP; Steffens, J; Stuthman, KS; Van Tongeren, SA; Warren, TK; Weidner, JM; Wells, J; Zeng, X | 1 |
| Casciano, R; Chandak, A; Gottlieb, RL; Haubrich, R; Hodgkins, P; Kuritzkes, DR; Liang, S; Mozaffari, E; Sax, PE; Thrun, M; Wohl, DA; Zhang, Z | 1 |
| Almario-Hernandez, AF; Doerholt, K; Drysdale, SB; Gilmour, C; Heath, PT; Pereira, NMD | 1 |
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| Abraham, GM; Etxeandia-Ikobaltzeta, I; Forciea, MA; Humphrey, LL; Jokela, JA; Miller, MC; Qaseem, A; Yost, J | 2 |
| Kaka, AS; Linskens, EJ; MacDonald, R; Wilt, TJ | 1 |
| Decimo, D; Favède, V; Ferren, M; Greninger, AL; Horvat, B; Iampietro, M; Lieberman, NAP; Mathieu, C; Mazelier, M; Messaddeq, N; Moscona, A; Pelissier, R; Porotto, M; Terrier, O; Weickert, JL | 1 |
| Deng, R; Ding, Q; Kwok, M; Lee, C; Leung, KT; Li, HS; Poon, EN; Tsang, SY; Tsoi, C; Yan, BP | 1 |
| Brainard, D; Cao, H; Carratalà, J; Cavalcante, AW; Diaz, G; Garcia-Diaz, J; Gordeev, I; Gordon, O; Gottlieb, RL; Graham, E; Hanania, NA; Hunter, BD; Lewin-Koh, N; Lobo, SM; Olsson, JK; Overcash, JS; Robinson, P; Rosas, IO; Skarbnik, A; Tsai, L; Tuckwell, K | 1 |
| Choi, YK; Han, HJ; Im, M; Jang, SG; Jeong, K; Kim, EH; Kim, YI | 1 |
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| Bisimwa, HM; Ciesielska, EJ; Ciesielski, GL; Grier, C; Kim, S; Oliveira, MT; Rahman, MM; Young, CKJ; Young, MJ | 1 |
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| Bal, W; Balwierz, W; Bień, E; Chaber, R; Dembowska-Bagińska, B; Gryniewicz-Kwiatkowska, O; Irga-Jaworska, N; Kazanowska, B; Krawczuk-Rybak, M; Kruk, A; Książek, A; Matkowska-Kocjan, A; Matysiak, M; Mizia-Malarz, A; Młynarski, W; Ociepa, T; Peregud-Pogorzelski, J; Pierlejewski, F; Raciborska, A; Sawicka-Żukowska, M; Styczyński, J; Szczepański, T; Szmydki-Baran, A; Ussowicz, M; Wachowiak, J; Węcławek-Tompol, J; Zając-Spychała, O; Zakrzewska, Z; Zaucha-Prażmo, A | 1 |
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| Abd-Elsalam, S; Abdul-Baki, EAM; El Ghafar, MSA; Elhendawy, M; Ibrahim, IS; Naguib, AM; Salama, M; Soliman, S; Torky, M | 1 |
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| Ali, S; Desai, K; Ghosh, S; Harris, I; Kiptanui, Z | 1 |
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| Chen, J; Han, F; Liu, Y; Mo, M; Wang, C; Wu, J; Yang, Y | 1 |
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| Bašić-Jukić, N; Sabljić, Z | 1 |
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| Dragioti, E; Jacob, L; Jung, SY; Kang, HC; Kim, JH; Kim, MS; Kostev, K; Koyanagi, A; Lascu, A; Lee, S; Lee, SW; Salem, JE; Shin, JI; Smith, L; Tizaoui, K; Yang, JW; Yon, DK | 1 |
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| Misra, A; Singh, A; Singh, AK; Singh, R | 1 |
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| Agoritsas, T; Bartoszko, JJ; Brignardello-Petersen, R; Chu, DK; Ge, L; Izcovich, A; Khamis, AM; Kum, E; McLeod, SL; Mustafa, RA; Qasim, A; Rochwerg, B; Siemieniuk, RA; Vandvik, P; Zeraatkar, D | 1 |
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| Catherine Muenker, M; Ferguson, D; Fournier, J; Gandhi, S; Greninger, AL; Iwasaki, A; Kerantzas, N; Klein, J; Ko, AI; Lin, MJ; Lindenbach, B; Lu, P; Mohamed Bakhash, SAK; Ogbuagu, O; Peña-Hernández, MA; Pyle, A; Robertson, AJ; Roychoudhury, P; Schulz, WL; Srivathsan, A; Wang, W; Wilen, CB; Wunder, EA | 1 |
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| Barsic, B; Bistrovic, P; Busic, N; Cesar, N; Cikara, T; Koscak, V; Lackovic, M; Lucijanic, M; Lucijanic, T; Mitrovic, J; Ortner Hadziabdic, M; Papic, I | 1 |
| Heise, MT; Hickey, AJ; Hwang, D; Kabanov, AV; Lim, C; Madden, EA; Ramsey, JD; Stewart, IE | 1 |
| Bilello, JP; Camus, G; Cihlar, T; Du Pont, V; Kurhade, C; Li, J; Lu, X; Maiorova, E; Manhas, S; Martin, R; Mo, H; Perry, JK; Pitts, J; Porter, DP; Riola, N; Rodriguez, L; Shi, PY; Xie, X | 1 |
| Bunyan, E; Jordan, R; Julander, JG; Porter, DP | 1 |
| Amarasinghe, N; Bruno, R; Colaneri, M; Gregorini, M; Meloni, F; Pelenghi, S; Pieri, TC; Rampino, T; Rezzonico, L; Ricciardi, A; Roda, S; Sambo, M; Segalini, E | 1 |
| de la Rica, A; Fernández, M; García, JA; García-Abellán, J; Gonzalo-Jiménez, N; Gutiérrez, F; Mascarell, P; Masiá, M; Padilla, S; Polotskaya, K | 1 |
| Vuppalanchi, R; Vuppalanchi, S | 1 |
| Agoritsas, T; Calmy, A; Huttner, A; Kaiser, L; Vetter, P | 1 |
| Abdel Hakiem, AF; Attia, TZ; Boushra, JM; Lashien, AS; Noureldeen, DAM | 1 |
| Cao, GH; Chen, YM; Li, JT; Li, RJ; Liu, CH; Song, LL; Song, XR; Tian, M; Yang, WL; Zhang, SF; Zhang, YD | 1 |
| Bistrovic, P; Jordan, A; Lucijanic, M; Manola, S; Ortner Hadziabdic, M; Papic, I | 1 |
| Kaur, M; Mukhopadhyay, K; Sidana, V; Tiwari, D | 1 |
| Brophy, JM; Butler-Laporte, G; Del Corpo, O; Lee, TC; McDonald, EG; Murthy, S; Senécal, J; Sohani, ZN | 1 |
| Alarcon, VB; Marikawa, Y | 1 |
| Antinori, S; Casalini, G; Cozzi-Lepri, A; Giacomelli, A; Oreni, L; Ridolfo, AL | 1 |
| Drosos, AA; Pelechas, E; Voulgari, PV | 1 |
| Chatterjee, B; Thakur, SS | 1 |
| Santos, WC; Viveiros Rosa, SG | 1 |
| Ader, F; Bouscambert-Duchamp, M; Burdet, C; Hites, M; Mentré, F; Peiffer-Smadja, N | 1 |
| Bosma, LBE; Leegwater, E; Moes, DJAR; Ottens, TH; van der Meer, IM; van Nieuwkoop, C; Wilms, EB | 1 |
| Dovjak, P; Heppner, HJ | 1 |
| Chanfreau, C; Chang, KM; Chen, HC; Chung, CP; Gorman, BR; Hung, AM; Hunt, CM; Joseph, J; Luoh, SW; Napolioni, V; Robinson-Cohen, C; Shah, SC; Suzuki, A; Tao, R; Tuteja, S; Wendt, F; Wilson, O; Yu, Z; Zhou, J | 1 |
| Arabidarrehdor, G; Chaturbedi, A; Florian, J; Han, X; Howard, KE; Li, Z; Mann, J; Rouse, R; Samieegohar, M; Strauss, DG; Weaver, JL; Zirkle, J | 1 |
| Andersson, LM; Brink, M; Gisslén, M; Lindh, M; Marklund, E; Nilsson, S; Robertson, J; Sourander, B; Sundell, N; Yilmaz, A | 1 |
| Boivin, G; Carbonneau, J; Checkmahomed, L; Du Pont, V; Li, J; Paré, B; Perry, JK; Porter, DP; Riola, NC; Simpson, SM; Smith, MA | 1 |
| Fischer, M; Luck, M; Müller, P; Scheidt, HA | 1 |
| Celant, S; Colatrella, A; Olimpieri, PP; Palù, G; Russo, P; Tacconelli, E; Tomassini, L | 1 |
| Belal, F; El-Awady, M; Elmansi, H; Shabana, RA | 1 |
| Li, R; Miao, H; Ruan, X; Tong, Z; Yu, J | 1 |
| Brandt, C; Deinhardt-Emmer, S; Doshi, H; Ehrhardt, C; Giebeler, L; Häring, C; Jungwirth, J; König, S; Löffler, B | 1 |
| Diószegi, Á; Farkas, K; Hevessy, Z; Illés, Á; Magyari, F; Nagy, B; Nagy, G; Páyer, E; Pinczés, LI; Sik, M; Simon, Z; Ujfalusi, S | 1 |
| Al Musawi, T; Alali, A; Alraddadi, B; Caravaggio, S; Harfouche, C; Jarrett, J; Kozma, S; Ruggeri, M; Signorini, A | 1 |
| Agrati, C; Ascoli Bartoli, T; Benvenuto, D; Marchioni, L; Nicastri, E; Stazi, GV; Tempestilli, M | 1 |
| Hirai, T; Inoue, T; Iwamoto, T; Mizuta, A; Nishikawa, K; Sasaki, T | 1 |
| Abdelazim, AH; Hasan, MA; Osman, AO; Ramzy, S | 1 |
| Drolet, B; Pilote, S; Simard, C | 1 |
| Ebenezer, O; Ginindza, TG; Jordaan, MA; Ogunsakin, RE; Shapi, M | 1 |
| Faughn, J; Ing, A; Kim, K; Montero, J; Piccicacco, N; Silbert, S; Zeitler, K | 1 |
| Aukrust, P; Barratt-Due, A; Dahl, TB; Dyrhol-Riise, AM; Halvorsen, B; Murphy, SL; Trøseid, M | 1 |
| Horii, H; Kamada, K; Kojima, Y; Konno, S; Matsumoto, M; Nakakubo, S; Nakamura, J; Sato, K; Shima, H; Suzuki, M; Takei, N; Yamashita, Y | 1 |
| Agarwal, G; Burkholder, GA; Erdmann, NB; Goepfert, PA; Hauptfeld-Dolejsek, V; Houp, JA; Kew, CE; Killian, AC; Killian, JT; Kumar, V; Leal, SM; Levitan, EB; Locke, JE; Lund, FE; Nellore, A; Ong, SC; Orandi, BJ; Porrett, PM; Roman Soto, SA; Zumaquero, E | 1 |
| Vatandaslar, H | 1 |
| Markowitz, JS; Melchert, PW; Zhang, Q | 1 |
| Bodro, M; Cacho, J; Cofàn, F; Cuadrado-Payán, E; Cucchiari, D; Diekmann, F; Gonzalez-Rojas, Á; Herrera, S; Montagud-Marrahi, E; Nicolás, D; Oppenheimer, F; Revuelta, I; Rico, V; Torres-Jaramillo, V; Ventura-Aguiar, P | 1 |
| Finsterer, J | 1 |
| Kaka, AS; Wilt, TJ | 1 |
| Ahsan, CH; Al-Taweel, O; Batra, K; Bauzon, JS; Cosme, C; Diep, J; Go, A; Hawwass, D; Houshmand, N; Inciong, K; Lee, K; Mohammed, S; Nasser, K; Pham, U; Rana, J; Schreiber, A; Sossou, C | 1 |
| Ferrara, F; Trama, U; Vitiello, A; Zovi, A | 1 |
| Hirata, H; Imakyure, O; Ishii, H; Kinoshita, Y; Kushima, H; Matsuo, K; Miyazaki, M; Moriwaki, N; Nakashima, A; Uchiyama, M; Yamada, Y; Yanagida, R | 1 |
| Cheng, M; Fowler, R; Murthy, S; Pinto, R; Sheehan, NL; Tseng, A | 1 |
| Bragantini, D; Domenici, E; Marchetti, L; Piretto, E; Selvaggio, G | 1 |
| Barczi, E; Dinya, E; Fazekas, L; Gajdacsi, J; Hidvegi, E; Maurovich-Horvat, P; Merkely, B; Müller, V; Polivka, L; Sebok, S; Sutto, Z; Szabo, AJ | 1 |
| Batista, VS; Konigsberg, WH; Lisi, GP; Lolis, E; Maschietto, F; Reiss, K; Shi, Y; Wang, J | 1 |
| Fitzpatrick, EA; Gao, W; He, M; Hu, H; Jonsson, CB; Li, R; Mady Traore, MD; Sun, D; Wen, B; Yuan, H | 1 |
| Addo, MM; Aepfelbacher, M; Fischer, N; Grundhoff, A; Günther, T; Heyer, A; Jarczak, D; Kluge, S; Lütgehetmann, M; Robitaille, A; Schulze Zur Wiesch, J | 1 |
| Alexander, J; Arya, V; Belew, Y; Birnkrant, D; Chan-Tack, K; Earp, J; Hausman, E; Sampson, M; Struble, K; Yao, L | 1 |
| Babudieri, S; Colpani, A; De Vito, A; Fanelli, C; Fiore, V; Fois, A; Fois, M; Lo Caputo, S; Madeddu, G; Meloni, MC; Poliseno, M; Puci, MV; Saderi, L; Santantonio, T; Sotgiu, G; Zauli, B | 1 |
| Bando, Y; Ishii, H; Otori, K; Yokota, N | 1 |
| Rochwerg, B; Tran, A | 1 |
| Cheong, HJ; Choi, YJ; Hyun, H; Kim, WJ; Nham, E; Noh, JY; Seong, H; Song, JY; Yoon, JG | 1 |
| Hashimoto, S; Kuraoka, N; Matsui, S | 1 |
| Aldrich, CC; Hegde, P; Orimoloye, M; Panda, S; Poudel, TN | 1 |
| Tsuji, M | 1 |
| Aiken, JM; Choi, S; Herbst, A; Hoang, AN; Kim, C; Martinez Moreno, D; McKenzie, D; Wanagat, J | 1 |
| Biering, SB; Chien, M; Dugast-Darzacq, C; Garzia, A; Graham, TGW; Jockusch, S; Ju, J; Meyer, C; Näär, AM; Nguyenla, X; Patel, DJ; Russo, JJ; Schaletzky, J; Stanley, S; Stroumza, J; Tao, C; Tuschl, T; Van Dis, E; Wang, X; Wehri, E; Xie, W; Yamashiro, LH; Zhu, C | 1 |
| Chafouleas, J; Cugia, G; De Forni, D; Lisziewicz, J; Lori, F; Poddesu, B | 1 |
| Arora, V; Barton, R; Chakraborty, A; Chiniga, V; Diwan, A; Holkar, N; Holkar, P; Pandey, R; Pond, B; Tatake, J; Thakur, Y | 1 |
| Bilello, JP; Chan, J; Chia, JJ; Cihlar, T; Cowfer, D; Feng, JY; Gong, R; Iversen, P; Kaptein, SJF; Leventhal, SM; Lu, X; Neyts, J; Porter, DP; Radoshitzky, SR; Sapre, AA; Shi, PY; Shornikov, A; Song, ZJ; Steffens, J; Stuthman, KS; Truong, H; Van Tongeren, SA; Warren, T; Wells, J; Xie, X; Yang, H; Yu, H; Zhang, X; Zou, J | 1 |
| Kalil, AC | 1 |
| Aldir, I; Campos, L; Carmo, E; Carmo, I; Carvalho, A; Coelho, L; Correia, J; Falcão, F; Farinha, H; Fonseca, C; Mansinho, K; Martins, AP; Mendes, D; Miranda, AC; Mirco, A; Póvoa, P; Soares, J; Solano, M; Viegas, E | 1 |
| Cardoza, S; Chatterjee, AK; Mandal, A; Riva, L; Shrivash, MK; Tandon, V | 1 |
| Bunyan, E; Cihlar, T; de Wit, E; Feldmann, F; Feldmann, H; Goldin, K; Lo, MK; Lovaglio, J; Okumura, A; Porter, DP; Saturday, G; Spiropoulou, CF; Williamson, BN | 1 |
| Camus, G; Gale, M; Greninger, AL; Han, D; Hao, L; Hedskog, C; Huang, ML; Ireton, RC; Jerome, KR; Li, J; Perry, JK; Porter, DP; Rodriguez, L; Roychoudhury, P | 1 |
| Anoshchenko, O; Chen, S; Davies, S; DeZure, A; Dresser, M; Ellis, S; Girish, S; Humeniuk, R; Johnston, M; Juneja, K; Llewellyn, J; Osinusi, A; Palaparthy, R; Share, A; Winter, H; Xiao, D | 1 |
239 review(s) available for alanine and adenosine monophosphate
| Article | Year |
|---|---|
Will There Be a Cure for Ebola?
Topics: Adenine; Adenosine; Adenosine Monophosphate; Africa, Western; Alanine; Animals; Antiviral Agents; Disease Outbreaks; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Purine Nucleosides; Pyrrolidines; Ribonucleotides | 2017 |
The path towards effective antivirals against rabies.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Drug Repositioning; Humans; Post-Exposure Prophylaxis; Pyrazines; Pyrrolidines; Rabies; Rabies virus | 2019 |
Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus Infections; Humans; Influenza, Human; Pandemics; Respiratory Syncytial Virus, Human; Respiratory Tract Infections | 2019 |
Understanding of COVID-19 based on current evidence.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Animals; Antiviral Agents; Betacoronavirus; China; Chiroptera; Communicable Disease Control; Coronavirus Infections; COVID-19; Disease Management; Humans; Oseltamivir; Pandemics; Pneumonia, Viral; SARS-CoV-2; Survival Analysis | 2020 |
Clinical trial analysis of 2019-nCoV therapy registered in China.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; China; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Disease Management; Disease Outbreaks; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Pandemics; Pneumonia, Viral; Practice Guidelines as Topic; Pyrazines; SARS-CoV-2 | 2020 |
Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Monoclonal; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Humans; Immunization, Passive; Interferon-beta; Lopinavir; Mice, Transgenic; Middle East Respiratory Syndrome Coronavirus; Pandemics; Pneumonia, Viral; Ribavirin; Ritonavir; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus | 2020 |
[Pharmacotherapeutics for the new coronavirus pneumonia].
Topics: Adenosine; Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antiviral Agents; China; Coronavirus Infections; COVID-19; Cytochrome P-450 CYP3A Inhibitors; Drug Therapy, Combination; Humans; Lopinavir; Pneumonia, Viral; Retrospective Studies; Ribonucleotides; Ritonavir | 2020 |
Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Alanine; Asymptomatic Infections; Betacoronavirus; China; Chloroquine; Comorbidity; Coronavirus Infections; COVID-19; Humans; Infection Control; Middle Aged; Pandemics; Pneumonia, Viral; SARS-CoV-2; Young Adult | 2020 |
Controversial treatments: An updated understanding of the coronavirus disease 2019.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Extracorporeal Membrane Oxygenation; Glucocorticoids; Humans; Liver, Artificial; Ribavirin | 2020 |
[Remdesivir, the antiviral hope against SARS-CoV-2].
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Potential therapeutic agents against COVID-19: What we know so far.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Drug Combinations; Humans; Hydroxychloroquine; Interferon-alpha; Lopinavir; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2 | 2020 |
Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azetidines; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Immunomodulation; Interferon-alpha; Lopinavir; Nelfinavir; Nitro Compounds; Pandemics; Pneumonia, Viral; Purines; Pyrazoles; Ribavirin; Ritonavir; SARS-CoV-2; Sulfonamides; Thiazoles | 2020 |
Drug repositioning is an alternative for the treatment of coronavirus COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Humans; Hydroxychloroquine; Pandemics; Pneumonia, Viral; SARS-CoV-2; Teicoplanin | 2020 |
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Amides; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Azithromycin; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Immunoglobulins; Immunologic Factors; Indoles; Lopinavir; Oseltamivir; Pandemics; Pneumonia, Viral; Pyrazines; Ribavirin; Ritonavir; SARS-CoV-2; Withholding Treatment | 2020 |
Antiviral treatment of COVID-19
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Hydroxychloroquine; Ivermectin; Lopinavir; Nitro Compounds; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; SARS-CoV-2; Thiazoles | 2020 |
Pharmacologic Treatment of Transplant Recipients Infected With SARS-CoV-2: Considerations Regarding Therapeutic Drug Monitoring and Drug-Drug Interactions.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Interactions; Drug Monitoring; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Pandemics; Pneumonia, Viral; Protease Inhibitors; SARS-CoV-2; Transplant Recipients | 2020 |
Novel 2019 coronavirus: Genome structure, clinical trials, and outstanding questions.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; China; Communicable Disease Control; Coronavirus Infections; COVID-19; Genome, Viral; Humans; Middle East Respiratory Syndrome Coronavirus; Pandemics; Pneumonia, Viral; SARS-CoV-2; Serine Proteinase Inhibitors; Severe acute respiratory syndrome-related coronavirus | 2020 |
Treatment options for COVID-19: The reality and challenges.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; RNA-Dependent RNA Polymerase; SARS-CoV-2; Teicoplanin | 2020 |
Respiratory Support in COVID-19 Patients, with a Focus on Resource-Limited Settings.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Continuous Positive Airway Pressure; Coronavirus Infections; COVID-19; Developing Countries; Disease Management; Humans; Hydroxychloroquine; Lopinavir; Lung; Oxygen; Pandemics; Pneumonia, Viral; Respiration, Artificial; Ritonavir; SARS-CoV-2; Tomography, X-Ray Computed | 2020 |
Scientific research progress of COVID-19/SARS-CoV-2 in the first five months.
Topics: Adenosine Monophosphate; Alanine; Amides; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; COVID-19 Testing; COVID-19 Vaccines; Disease Progression; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunization, Passive; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Pyrazines; SARS-CoV-2; Severity of Illness Index; Spike Glycoprotein, Coronavirus; Viral Vaccines | 2020 |
[Remdesivir for patients with severe COVID-19].
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; Severity of Illness Index | 2020 |
Pharmacotherapy in COVID-19; A narrative review for emergency providers.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Amides; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Hydroxychloroquine; Interleukin-6; Pandemics; Pneumonia, Viral; Pyrazines; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2020 |
Treatment of SARS-CoV-2: How far have we reached?
Topics: Adenosine Monophosphate; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Darunavir; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferon-alpha; Interferon-beta; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; SARS-CoV-2 | 2020 |
Addressing the Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hematopoietic Cell Transplantation: Learning Networks as a Means for Sharing Best Practices.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Bone Marrow Transplantation; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; COVID-19 Testing; Drug Combinations; Education, Distance; Hematopoietic Stem Cell Transplantation; Humans; Hydroxychloroquine; Immunization, Passive; Infection Control; Information Dissemination; Lopinavir; Pandemics; Pneumonia, Viral; Practice Guidelines as Topic; Real-Time Polymerase Chain Reaction; Ritonavir; SARS-CoV-2; Severity of Illness Index; Tissue Donors | 2020 |
Medical treatment options for COVID-19.
Topics: Adenosine Monophosphate; Administration, Intravenous; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Cytochrome P-450 CYP3A Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunologic Factors; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Recombinant Proteins; RNA, Viral; SARS-CoV-2 | 2020 |
Potential therapeutic targets and promising drugs for combating SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Basigin; Benzamidines; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Cytokine Release Syndrome; Esters; Gabexate; Genome, Viral; Guanidines; Humans; Immunization, Passive; Immunosuppressive Agents; Medicine, Chinese Traditional; Nucleic Acid Synthesis Inhibitors; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Protease Inhibitors; RNA-Dependent RNA Polymerase; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Viral Vaccines; Virus Internalization; Virus Replication | 2020 |
Rapid review for the anti-coronavirus effect of remdesivir.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Humans; Middle East Respiratory Syndrome Coronavirus; Pandemics; Pneumonia, Viral; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus | 2020 |
Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Humans; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2021 |
Severe Covid-19.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Brain; COVID-19; COVID-19 Testing; Dexamethasone; Dyspnea; Humans; Lung; Male; Middle Aged; Patient Acuity; Radiography, Thoracic; Respiration, Artificial; Respiratory Distress Syndrome; SARS-CoV-2; Tomography, X-Ray Computed | 2020 |
COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokine Release Syndrome; Cytokines; Drug Therapy, Combination; Humans; Inflammation; Interferons; Oligonucleotides; Pandemics; Pneumonia, Viral; SARS-CoV-2; Viral Vaccines | 2020 |
Medicines for the Treatment Of COVID-19: Awaiting the Evidence.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Drug Combinations; Drugs, Investigational; Global Health; Humans; Hydroxychloroquine; Lopinavir; Off-Label Use; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2 | 2020 |
Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Alanine; Anti-Infective Agents; Azithromycin; Betacoronavirus; Cardiovascular Diseases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Enzyme Inhibitors; Humans; Hydroxychloroquine; Lopinavir; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2 | 2020 |
Just the facts: What drugs are safe and effective for COVID-19?
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antiviral Agents; Coronavirus Infections; COVID-19; Drug Therapy; Humans; Male; Middle Aged; Needs Assessment; Pandemics; Patient Safety; Pneumonia, Viral; Risk Assessment; Severe Acute Respiratory Syndrome; Severity of Illness Index; Steroids; Treatment Outcome | 2020 |
Ebola.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Disease Outbreaks; Ebola Vaccines; Ebolavirus; Hemorrhagic Fever, Ebola; Humans | 2020 |
A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Drug Combinations; Humans; Hydroxychloroquine; Interferon beta-1a; Lopinavir; Middle East Respiratory Syndrome Coronavirus; Pandemics; Respiration, Artificial; Ritonavir; SARS-CoV-2; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Severity of Illness Index | 2020 |
Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir in Treatment of COVID-19: A Systematic Benefit-Risk Assessment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; Risk Assessment; SARS-CoV-2; Treatment Outcome | 2020 |
Educational case series of electrocardiographs during the COVID-19 pandemic and the implications for therapy.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronavirus Infections; COVID-19; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Pandemics; Pneumonia, Viral; Sampling Studies; Severe Acute Respiratory Syndrome; Singapore; Treatment Outcome | 2020 |
A current review of COVID-19 for the cardiovascular specialist.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Biomarkers; Cardiovascular Diseases; Chloroquine; Coronavirus Infections; COVID-19; Humans; Hydroxychloroquine; Hypoxia; Pandemics; Plasma; Pneumonia, Viral; Receptor, Angiotensin, Type 2; Risk Factors; SARS-CoV-2; Takotsubo Cardiomyopathy; Virus Internalization | 2020 |
Coronavirus Disease 2019: Clinical Review.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antiviral Agents; Azithromycin; Betacoronavirus; Blood Coagulation Disorders; China; Chiroptera; Chloroquine; Coronavirus Infections; COVID-19; Glucocorticoids; Humans; Hydroxychloroquine; Infectious Disease Incubation Period; Lopinavir; Lung; Pandemics; Pneumonia, Viral; Prognosis; Pyrazines; Radiography, Thoracic; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Symptom Assessment | 2020 |
COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2.
Topics: Acetylcysteine; Adenosine Monophosphate; Adjuvants, Immunologic; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Autophagy; Betacoronavirus; Colchicine; Copper; Coronavirus Infections; COVID-19; Cytidine; Drug Synergism; Drug Therapy, Combination; Humans; Hydroxylamines; Inflammation; Nitric Oxide; Pandemics; Pneumonia, Viral; Prodrugs; Ribonucleosides; SARS-CoV-2; Virus Internalization; Virus Replication | 2020 |
Potential Antiviral Drugs for SARS-Cov-2 Treatment: Preclinical Findings and Ongoing Clinical Research.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Drugs, Investigational; Humans; Indoles; Lopinavir; Multicenter Studies as Topic; Neuraminidase; Pandemics; Pneumonia, Viral; Primates; Ribavirin; Ritonavir; SARS-CoV-2; Treatment Outcome | 2020 |
Use of Remdesivir in the Management of COVID-19: A Systematic Review on Current Evidences.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; Prospective Studies; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2020 |
Remdesivir in Patients with Acute or Chronic Kidney Disease and COVID-19.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Alanine; Antiviral Agents; Cause of Death; Comorbidity; Coronavirus Infections; COVID-19; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Kidney Failure, Chronic; Male; Massachusetts; Pandemics; Pneumonia, Viral; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Survival Rate | 2020 |
Potential drugs for the treatment of the novel coronavirus pneumonia (COVID-19) in China.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; China; Chloroquine; Coronavirus Infections; COVID-19; Drug Combinations; Drugs, Chinese Herbal; Humans; Indoles; Interferons; Lopinavir; Lung; Pandemics; Pneumonia, Viral; Pyrazines; Ribavirin; Ritonavir; SARS-CoV-2; Survival Analysis | 2020 |
Infant With SARS-CoV-2 Infection Causing Severe Lung Disease Treated With Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Female; Humans; Infant; Infant, Premature; Intensive Care Units; Intubation, Intratracheal; Pandemics; Patient Discharge; Pneumonia, Viral; Radiography, Thoracic; Respiration, Artificial; Severe Acute Respiratory Syndrome; Treatment Outcome | 2020 |
[COVID-19 trials: surfing between expectations and illusions, looking forward to evidence].
Topics: Adenosine Monophosphate; Alanine; Coronavirus Infections; COVID-19; Female; Humans; Hydroxychloroquine; Italy; Male; Pandemics; Pneumonia, Viral; Prevalence; Randomized Controlled Trials as Topic; Risk Assessment | 2020 |
Investigational Therapies for the Treatment of COVID-19: Updates from Ongoing Clinical Trials.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral Agents; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Humans; Hydroxychloroquine; Immunization, Passive; Immunologic Factors; Pandemics; Pneumonia, Viral; Receptors, Interleukin-6; SARS-CoV-2 | 2020 |
A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Emerging pharmacotherapy for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokines; Enzyme Inhibitors; Humans; Hydroxychloroquine; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Have we found the panacea to COVID-19 with remdesivir, an old but newly packaged drug?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
COVID-19: Review on latest available drugs and therapies against SARS-CoV-2. Coagulation and inflammation cross-talking.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Anticoagulants; Antiviral Agents; Azetidines; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokine Release Syndrome; Disseminated Intravascular Coagulation; Drug Combinations; Heparin; Humans; Hydroxychloroquine; Inflammation; Interleukin 1 Receptor Antagonist Protein; Lopinavir; Pandemics; Pneumonia, Viral; Purines; Pyrazoles; Ritonavir; SARS-CoV-2; Sulfonamides | 2020 |
[Drug treatment of coronavirus disease COVID-19: evidence exists?]
Topics: Adenosine Monophosphate; Alanine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2; Tissue Plasminogen Activator | 2020 |
Antiviral mechanisms of candidate chemical medicines and traditional Chinese medicines for SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; China; Coronavirus Infections; COVID-19; Drug Combinations; Drugs, Chinese Herbal; Humans; Hydroxychloroquine; Indoles; Interferons; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ribavirin; Ritonavir; SARS-CoV-2; Survival Analysis; Teicoplanin | 2020 |
Current pharmacological treatments for SARS-COV-2: A narrative review.
Topics: Adenosine Monophosphate; Adjuvants, Immunologic; Alanine; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Glucocorticoids; Heparin, Low-Molecular-Weight; Humans; Hydroxychloroquine; Immunity, Innate; Inflammation Mediators; Oseltamivir; Pandemics; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
Clinical management of COVID-19.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Airway Management; Alanine; Antibodies, Monoclonal, Humanized; Antimalarials; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Critical Illness; Humans; Hydroxychloroquine; Immunization, Passive; Pandemics; Patient Acuity; Pneumonia, Viral; SARS-CoV-2; Shock; Specimen Handling; Symptom Assessment; Vulnerable Populations | 2020 |
Molecular mechanisms and epidemiology of COVID-19 from an allergist's perspective.
Topics: Adenosine Monophosphate; Age Factors; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Asthma; Betacoronavirus; Clinical Laboratory Techniques; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Drug Repositioning; Humans; Masks; Pandemics; Peptidyl-Dipeptidase A; Physical Distancing; Pneumonia, Viral; Prevalence; Quarantine; Receptors, Virus; SARS-CoV-2; Severity of Illness Index; Spike Glycoprotein, Coronavirus | 2020 |
Clinical Trials of Repurposed Antivirals for SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Administration Schedule; Drug Combinations; Drug Repositioning; Humans; Hydroxychloroquine; Interferons; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Randomized Controlled Trials as Topic; Ribavirin; Ritonavir; SARS-CoV-2; Survival Analysis; Treatment Outcome | 2020 |
CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection.
Topics: Adenosine Monophosphate; Alanine; Animals; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Blood-Brain Barrier; Brain; Central Nervous System Agents; Coronavirus Infections; COVID-19; Drug Evaluation, Preclinical; Humans; Methylprednisolone; Pandemics; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
Is hydroxychloroquine beneficial for COVID-19 patients?
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cytokines; Humans; Hydroxychloroquine; Pandemics; Pneumonia, Viral; Risk; SARS-CoV-2 | 2020 |
Current pharmacological modalities for management of novel coronavirus disease 2019 (COVID-19) and the rationale for their utilization: A review.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Disease Progression; Drug Combinations; Drug Repositioning; Esters; Gabexate; Gene Expression Regulation; Guanidines; Host-Pathogen Interactions; Humans; Hydroxychloroquine; Indoles; Lopinavir; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Ritonavir; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2020 |
Characteristics of the Multiplicity of Randomized Clinical Trials for Coronavirus Disease 2019 Launched During the Pandemic.
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antimalarials; Antiviral Agents; Azithromycin; Betacoronavirus; Biological Products; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Humans; Hydroxychloroquine; Immunization, Passive; Non-Randomized Controlled Trials as Topic; Pandemics; Pneumonia, Viral; Protease Inhibitors; Protein-Tyrosine Kinases; Randomized Controlled Trials as Topic; Respiration, Artificial; SARS-CoV-2; Viral Load | 2020 |
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Drug Discovery; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Middle East Respiratory Syndrome Coronavirus; Pyrazines; RNA-Dependent RNA Polymerase; SARS-CoV-2; Viral Proteins; Virus Replication | 2020 |
Hypothetical targets and plausible drugs of coronavirus infection caused by SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Humans; Pandemics; SARS-CoV-2 | 2021 |
Systematic review and meta-analysis of effectiveness of treatment options against SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19; COVID-19 Serotherapy; Drug Administration Schedule; Drug Combinations; Female; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Male; Middle Aged; Odds Ratio; Ritonavir; SARS-CoV-2; Survival Analysis; Treatment Outcome | 2021 |
Re-tasking the use of pre-existing medications and potential therapeutic options for coronavirus disease (COVID-19): systematic review of clinical studies.
Topics: Adenosine Monophosphate; Alanine; Antirheumatic Agents; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Drug Repositioning; Humans; Hydroxychloroquine; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics.
Topics: Adenosine Monophosphate; Alanine; Amides; Angiotensin-Converting Enzyme Inhibitors; Antimalarials; Antiviral Agents; Betacoronavirus; Biomedical Research; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Drug Combinations; Drug Development; Drugs, Chinese Herbal; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferons; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ribavirin; Ritonavir; SARS-CoV-2 | 2020 |
Antimalarial and cytotoxic drugs on COVID-19 and the cardiovascular burden: Literature review and lessons to be learned.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Azithromycin; Cardiovascular Diseases; Chemically-Induced Disorders; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Humans; SARS-CoV-2 | 2021 |
Use of remdesivir for patients with Covid-19: a review article.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Safety profile of the antiviral drug remdesivir: An update.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Female; Humans; Pregnancy | 2020 |
Emerging treatments in COVID-19: Adverse drug reactions including drug hypersensitivities.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokine Release Syndrome; Drug Hypersensitivity; Humans; Immunity, Innate; Immunologic Factors; Indoles; Infliximab; Interleukin 1 Receptor Antagonist Protein; Nitriles; Pandemics; Pneumonia, Viral; Pyrazines; Pyrazoles; Pyrimidines; SARS-CoV-2; Severity of Illness Index | 2020 |
Nanomedicine as a promising approach for diagnosis, treatment and prophylaxis against COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Drug Repositioning; Host Microbial Interactions; Humans; Nanomedicine; Nanotechnology; Pandemics; Pneumonia, Viral; SARS-CoV-2; Vaccines, Synthetic; Viral Vaccines | 2020 |
Severe Acute Respiratory Syndrome Coronavirus 2 and Coronavirus Disease 2019: A Clinical Overview and Primer.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; SARS-CoV-2 | 2020 |
Remdesivir for the Treatment of COVID-19: A Systematic Review of the Literature.
Topics: Adenosine Monophosphate; Administration, Intravenous; Alanine; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
COVID-19 and liver disease: An update.
Topics: Adenosine Monophosphate; Age Factors; Alanine; Antiviral Agents; Betacoronavirus; Bile Ducts; Chemical and Drug Induced Liver Injury; Chronic Disease; Comorbidity; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Disease Susceptibility; Gastroenterology; Health Resources; Hepatitis, Chronic; Humans; Immunosuppressive Agents; Liver; Liver Diseases; Liver Function Tests; Liver Transplantation; Obesity; Pandemics; Pneumonia, Viral; Resource Allocation; Risk Factors; SARS-CoV-2 | 2020 |
Drug treatments for covid-19: living systematic review and network meta-analysis
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Centers for Disease Control and Prevention, U.S.; China; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Databases, Factual; Drug Combinations; Evidence-Based Medicine; Glucocorticoids; Humans; Hydroxychloroquine; Lopinavir; Network Meta-Analysis; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; Respiration, Artificial; Ritonavir; SARS-CoV-2; Severity of Illness Index; Standard of Care; Treatment Outcome; United States | 2020 |
A Perspective on Emerging Therapeutic Interventions for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; COVID-19; Humans; Hydroxychloroquine; Public Health; Vaccines; Virus Replication | 2020 |
Remdesivir-induced symmetrical drug-related intertriginous and flexural exanthema (SDRIFE)? A case report with review of the literature.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Eruptions; Exanthema; Humans; Male | 2021 |
Update on recommendations for the diagnosis and treatment of SARS-CoV-2 infection in children.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Asymptomatic Diseases; Betacoronavirus; Biomarkers; Child; Clinical Laboratory Techniques; Coronavirus Infections; Cough; COVID-19; COVID-19 Testing; Drug Combinations; Early Diagnosis; Fever; Humans; Hydroxychloroquine; Interferon-alpha; Lopinavir; Pandemics; Pneumonia, Viral; Practice Guidelines as Topic; Ribavirin; Ritonavir; RNA, Viral; SARS-CoV-2; Severity of Illness Index; Tomography, X-Ray Computed | 2020 |
Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Combinations; Humans; Indoles; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; SARS-CoV-2 | 2020 |
Potential strategies for combating COVID-19.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; COVID-19 Vaccines; Cytokine Release Syndrome; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Immunologic Factors; Indoles; Interleukin 1 Receptor Antagonist Protein; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; SARS-CoV-2; Severity of Illness Index; Viral Vaccines | 2020 |
Efficacy of various treatment modalities for nCOV-2019: A systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Europe; Female; Humans; Lopinavir; Male; Pandemics; Pneumonia, Viral; Prognosis; Ritonavir; Survival Analysis; Treatment Outcome | 2020 |
Effectiveness of remdesivir for the treatment of hospitalized COVID-19 persons: A network meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Hospitalization; Humans; Network Meta-Analysis; Treatment Outcome | 2021 |
COVID-19 and the burning issue of drug interaction: never forget the ECG.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral Agents; Arrhythmias, Cardiac; Chloroquine; COVID-19 Drug Treatment; Drug Combinations; Drug Interactions; Electrocardiography; Heart Failure; Humans; Hydroxychloroquine; Hypoxia; Inflammation; Long QT Syndrome; Lopinavir; Myocarditis; Myocardium; Precipitating Factors; Receptors, Interleukin-6; Respiratory Distress Syndrome; Ribavirin; Ritonavir; SARS-CoV-2; Water-Electrolyte Imbalance | 2021 |
A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; Virus Replication | 2020 |
Effect of remdesivir on patients with COVID-19: A network meta-analysis of randomized control trials.
Topics: Adenosine Monophosphate; Alanine; Antimetabolites; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Disease Progression; Drug Administration Schedule; Humans; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; SARS-CoV-2; Severity of Illness Index; Survival Analysis; Treatment Outcome | 2020 |
Drug Discovery by Drug Repurposing: Combating COVID-19 in the 21st Century.
Topics: Adenosine Monophosphate; Alanine; Animals; Antimalarials; Antiviral Agents; Chloroquine; COVID-19 Drug Treatment; Drug Discovery; Drug Repositioning; Humans; Hydroxychloroquine; SARS-CoV-2 | 2021 |
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2.
Topics: Adenosine Monophosphate; Age Factors; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Chloroquine; Communicable Disease Control; Coronavirus Infections; COVID-19; Drug Repositioning; Humans; Incidence; Pandemics; Personal Protective Equipment; Physical Distancing; Pneumonia, Viral; Quarantine; SARS-CoV-2; Severity of Illness Index; Survival Analysis | 2020 |
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Cytidine; Genome, Viral; Humans; Hydroxylamines; Molecular Targeted Therapy; Mutation; Pandemics; Pneumonia, Viral; Pyrazines; Ribonucleosides; RNA, Viral; SARS-CoV-2; Severity of Illness Index; Transcription, Genetic; Viral Nonstructural Proteins; Virus Replication | 2020 |
[Pharmacological treatment of COVID-19: Narrative review of the Working Group in Infectious Diseases and Sepsis (GTEIS) and the Working Groups in Transfusions and Blood Products (GTTH)].
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticoagulants; Antiviral Agents; Azithromycin; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Disease Progression; Humans; Hydroxychloroquine; Immunization, Passive; Immunoglobulins, Intravenous; Immunomodulation; Interferon-beta; Interleukin 1 Receptor Antagonist Protein; Lopinavir; Nitriles; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Ritonavir; SARS-CoV-2 | 2021 |
Developing an Ethics Framework for Allocating Remdesivir in the COVID-19 Pandemic.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drugs, Investigational; Health Care Rationing; Humans; Minnesota; Pandemics; Pneumonia, Viral; SARS-CoV-2; United States; United States Food and Drug Administration | 2020 |
Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Hydroxychloroquine; Lopinavir; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2 | 2020 |
Remdesivir: First Approval.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Development; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir emergency approvals: a comparison of the U.S., Japanese, and EU systems.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Approval; Emergency Medical Services; European Union; Humans; Japan; Pandemics; Pneumonia, Viral; SARS-CoV-2; United States | 2020 |
The effect of antivirals on COVID-19: a systematic review.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Humans; Ritonavir; Treatment Outcome | 2021 |
Important Pharmacogenetic Information for Drugs Prescribed During the SARS-CoV-2 Infection (COVID-19).
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Chloroquine; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Pharmacogenetics; SARS-CoV-2 | 2020 |
A Review of the Preclinical and Clinical Efficacy of Remdesivir, Hydroxychloroquine, and Lopinavir-Ritonavir Treatments against COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Drug Therapy, Combination; Humans; Hydroxychloroquine; Lopinavir; Ritonavir; SARS-CoV-2; Treatment Outcome | 2020 |
RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Catalytic Domain; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Drug Discovery; Humans; Nucleic Acid Synthesis Inhibitors; Protein Conformation; RNA, Viral; SARS-CoV-2; Virus Replication | 2021 |
Evaluation of current medical approaches for COVID-19: a systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Antirheumatic Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Immunoglobulins, Intravenous; Immunologic Factors; Indoles; Lopinavir; Medicine, Chinese Traditional; Ritonavir; SARS-CoV-2; Treatment Outcome | 2021 |
Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; COVID-19 Vaccines; Gene Expression; Host-Pathogen Interactions; Humans; Hydroxychloroquine; Immunization, Passive; Ivermectin; Models, Molecular; Niclosamide; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Protein Interaction Domains and Motifs; Protein Structure, Secondary; SARS-CoV-2; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus; Viral Vaccines | 2020 |
A contemporary look at COVID-19 medications: available and potentially effective drugs.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Humans; Imatinib Mesylate; Lopinavir; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2 | 2020 |
Advances in SARS-CoV-2: a systematic review.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Extracorporeal Membrane Oxygenation; Glucocorticoids; Humans; Immunization, Passive; Immunotherapy; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Current treatment of COVID-19 in renal patients: hope or hype?
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Amides; Antibodies, Monoclonal; Cobicistat; Coronavirus Infections; COVID-19; Darunavir; Drug Combinations; Humans; Kidney; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Renal Insufficiency, Chronic; Renal Replacement Therapy; Ritonavir | 2020 |
COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antibodies, Viral; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Repositioning; Humans; Immunization, Passive; Medicine, Chinese Traditional; Pandemics; Pyrazines; SARS-CoV-2; World Health Organization | 2020 |
Remdesivir-COVID-19: drug interactions in dentistry.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Dentistry; Drug Interactions; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Benzamidines; COVID-19 Drug Treatment; Drug Repositioning; Esters; Guanidines; Guanine; Humans; Indoles; Lopinavir; Protease Inhibitors; Pyrazines; Ribavirin; Ritonavir; SARS-CoV-2; Virus Internalization; Virus Replication | 2021 |
Remdesivir for Adults With COVID-19 : A Living Systematic Review for American College of Physicians Practice Points.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Administration Schedule; Humans; Length of Stay; Randomized Controlled Trials as Topic; SARS-CoV-2; Severity of Illness Index | 2021 |
Systemic Medications of Dermatological Importance in COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Biological Products; Coronavirus Infections; COVID-19; Dermatologic Agents; Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Pandemics; Pneumonia, Viral; Prognosis; Risk Assessment; Severe Acute Respiratory Syndrome | 2020 |
Tackling COVID-19 Using Remdesivir and Favipiravir as Therapeutic Options.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrazines; SARS-CoV-2 | 2021 |
SARS-CoV-2 pharmacologic therapies and their safety/effectiveness according to level of evidence.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Drug Combinations; Evidence-Based Medicine; Humans; Hydroxychloroquine; Interferon beta-1b; Lopinavir; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Ribavirin; Ritonavir; Systematic Reviews as Topic | 2020 |
Remdesivir against COVID-19 and Other Viral Diseases.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Compassionate Use Trials; Coronavirus Infections; COVID-19; Drug Administration Schedule; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Middle East Respiratory Syndrome Coronavirus; Pandemics; Patient Safety; Pneumonia, Viral; SARS-CoV-2; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Survival Analysis; Treatment Outcome | 2020 |
Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; China; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2021 |
Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chiroptera; Coronavirus Protease Inhibitors; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Humans; Lopinavir; Ritonavir; SARS-CoV-2; Virus Attachment; Virus Internalization | 2021 |
Computational and theoretical exploration for clinical suitability of Remdesivir drug to SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Humans; Molecular Dynamics Simulation; SARS-CoV-2 | 2021 |
Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antiviral Agents; Biological Products; COVID-19; COVID-19 Drug Treatment; Cytokines; Dexamethasone; Drug Therapy, Combination; Humans; Inflammation Mediators; Intensive Care Units; Pandemics; Retrospective Studies; SARS-CoV-2 | 2020 |
Severe Acute Respiratory Distress Syndrome Secondary to Coronavirus 2 (SARS-CoV-2).
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Humans; Immunization, Passive; Lung; Pandemics; Pneumonia, Viral; Positive-Pressure Respiration; Respiratory Distress Syndrome; SARS-CoV-2; United States | 2020 |
Effect of remdesivir on mortality in patients with COVID-19: A meta-analysis of randomized control trials.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic | 2021 |
Remdesivir: A potential game-changer or just a myth? A systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antibodies, Monoclonal; Antibodies, Viral; Antiviral Agents; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Testing; Disease Reservoirs; Drug Repositioning; Humans; Immunoenzyme Techniques; Immunotherapy; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Receptors, Virus; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Serologic Tests; Spike Glycoprotein, Coronavirus | 2020 |
Remdesivir: Critical Clinical Appraisal for COVID 19 Treatment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Drug Approval; Humans; RNA, Viral; SARS-CoV-2; Treatment Outcome; United States; United States Food and Drug Administration | 2021 |
Emerging treatment strategies for COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Humans; Hydroxychloroquine; Immunization, Passive; Palliative Care; Pyrazines; SARS-CoV-2; Treatment Outcome | 2021 |
Efficacy and safety of remdesivir in hospitalized Covid-19 patients: Systematic review and meta-analysis including network meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Network Meta-Analysis; SARS-CoV-2 | 2021 |
Use of remdesivir in the presence of elevated LFTs for the treatment of severe COVID-19 infection.
Topics: Adenosine Monophosphate; Aged, 80 and over; Alanine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Emergency Service, Hospital; Humans; Length of Stay; Liver Diseases; Liver Function Tests; Male; Pandemics; Patient Discharge; Pneumonia, Viral; Respiratory Insufficiency; Severity of Illness Index; Treatment Outcome | 2020 |
New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Breast Feeding; Clinical Trials as Topic; Coronavirus Infections; COVID-19 Drug Treatment; Female; Humans; Immunocompromised Host; Middle East Respiratory Syndrome Coronavirus; Pregnancy; SARS-CoV-2 | 2020 |
A comprehensive review on sarilumab in COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Humans; Pandemics; SARS-CoV-2 | 2021 |
Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antioxidants; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Humans; SARS-CoV-2; Treatment Outcome; Virus Internalization | 2021 |
Remdesivir: A beacon of hope from Ebola virus disease to COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; SARS-CoV-2; Treatment Outcome; Virus Replication | 2020 |
An effective drug against COVID-19: reality or dream?
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Drug Development; Humans; Pandemics; Pyrazines | 2021 |
Clinical studies assessing the efficacy, effectiveness and safety of remdesivir in management of COVID-19: A scoping review.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
One year update on the COVID-19 pandemic: Where are we now?
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antiviral Agents; Chloroquine; Clinical Trials as Topic; Coronavirus; Coronavirus Infections; COVID-19; COVID-19 Vaccines; Drug Combinations; Drug Repositioning; Glucocorticoids; Humans; Hydroxychloroquine; Indoles; Ivermectin; Lopinavir; Mutation; Pandemics; Phytotherapy; Plant Extracts; Pyrazines; Ritonavir; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Tinospora; Viral Zoonoses | 2021 |
The COVID-19 pandemic: consequences for nephrology.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Glucocorticoids; Humans; Kidney Failure, Chronic; Kidney Transplantation; Nephrology; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors; SARS-CoV-2; Severity of Illness Index | 2021 |
Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; Compassionate Use Trials; COVID-19; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
USA stockpiling of remdesivir: How should the world respond?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; International Cooperation; Internationality; SARS-CoV-2; Strategic Stockpile; United States | 2020 |
Application of machine intelligence technology in the detection of vaccines and medicines for SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Artificial Intelligence; Ascorbic Acid; Chloroquine; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Deep Learning; Drug Combinations; Drug Development; Drug Repositioning; Humans; Hydroxychloroquine; Immunosuppressive Agents; Lopinavir; Machine Learning; Ribavirin; Ritonavir; Vitamins | 2020 |
Repurposing drugs for the management of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Female; Humans; Male; SARS-CoV-2 | 2021 |
Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome | 2020 |
Remdesivir for the treatment of coronavirus COVID-19: A meta-analysis of randomised controlled trials.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic | 2021 |
Treatment Options for Coronavirus Disease 2019 in Patients With Reduced or Absent Kidney Function.
Topics: Adenosine Monophosphate; Alanine; Amides; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Creatinine; Cytidine; Dexamethasone; Drug Combinations; Drug Interactions; Humans; Hydroxychloroquine; Hydroxylamines; Immunization, Passive; Interferons; Janus Kinase Inhibitors; Lopinavir; Pyrazines; Renal Elimination; Renal Insufficiency, Chronic; Renal Replacement Therapy; Ribavirin; Ritonavir; SARS-CoV-2 | 2020 |
Update on COVID-19 Myocarditis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Humans; Immunization, Passive; Myocarditis; SARS-CoV-2; Steroids | 2020 |
Therapeutic and Vaccine Options for COVID-19: Status after Six Months of the Disease Outbreak.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Dexamethasone; Humans; Immunization, Passive; Pyrazines; SARS-CoV-2; Viral Proteins | 2021 |
Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Dose-Response Relationship, Drug; Drug Repositioning; Humans; Hydroxychloroquine; Kidney Diseases; Liver Diseases | 2021 |
Possible treatment and strategies for COVID-19: review and assessment.
Topics: Adenosine Monophosphate; Alanine; Amides; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiparasitic Agents; Antiviral Agents; Cannabinoids; Chloroquine; Complement Inactivating Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Dexamethasone; Drug Combinations; Enzyme Inhibitors; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferons; Ivermectin; Lopinavir; Nitro Compounds; Pyrazines; Ritonavir; SARS-CoV-2; Teicoplanin; Tetracyclines; Thiazoles | 2020 |
Can drug repurposing strategies be the solution to the COVID-19 crisis?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Drug Therapy, Combination; Humans | 2021 |
Remdesivir for the treatment of COVID-19: a living systematic review.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic; Respiration, Artificial; Treatment Outcome | 2020 |
Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Compassionate Use Trials; COVID-19 Drug Treatment; Humans; Hydroxychloroquine | 2021 |
Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Azithromycin; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Critical Illness; Hospitalization; Humans; Hydroxychloroquine; Immunization, Passive; Network Meta-Analysis; Observational Studies as Topic; Randomized Controlled Trials as Topic | 2020 |
Remdesivir: From Ebola to COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Discovery; Hemorrhagic Fever, Ebola; Humans | 2021 |
Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Time Factors; Treatment Outcome | 2021 |
Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Monitoring; Humans; Predictive Value of Tests; Treatment Outcome | 2021 |
Remdesivir for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome | 2021 |
Timing of remdesivir for COVID-19.
Topics: Adenosine Monophosphate; Administration, Intravenous; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Hospitalization; Humans; Recovery of Function; Time Factors | 2020 |
Antiviral treatment in COVID-19: which is the most promising?-a narrative review.
Topics: Adenosine Monophosphate; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azetidines; Chloroquine; COVID-19; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferons; Ivermectin; Lopinavir; Nitro Compounds; Oseltamivir; Purines; Pyrazines; Pyrazoles; Ribavirin; Ritonavir; Sulfonamides; Thiazoles | 2021 |
[Pharmacovigilance update].
Topics: Adenosine Monophosphate; Alanine; Cleft Lip; Contraindications, Drug; COVID-19 Drug Treatment; Cytokine Release Syndrome; Female; Fingolimod Hydrochloride; Humans; Hydroxychloroquine; Leiomyoma; Norpregnadienes; Pharmacokinetics; Pharmacovigilance; Pregnancy; Ranitidine; Safety-Based Drug Withdrawals; Skin Neoplasms | 2021 |
A complementary critical appraisal on systematic reviews regarding the most efficient therapeutic strategies for the current COVID-19 (SARS-CoV-2) pandemic.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Databases, Factual; Humans; Hydroxychloroquine; Immunoglobulins; Lopinavir; Pandemics; Pyrazines; Respiration, Artificial; Ritonavir; SARS-CoV-2 | 2021 |
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Drug Development; Drug Repositioning; Humans; Hydroxylamines; Pyrazines; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2021 |
The History, Efficacy, and Safety of Potential Therapeutics: A Narrative Overview of the Complex Life of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19; COVID-19 Serotherapy; Humans; Hydroxychloroquine; Immunization, Passive; Pandemics; Pyrazines | 2021 |
Remdesivir as a broad-spectrum antiviral drug against COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; Diabetes Complications; Glucocorticoids; Humans; Kidney Failure, Chronic; Male; Middle Aged; Mucormycosis; Rhizopus; Risk Factors; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
COVID-19 and Its Implications for Thrombosis and Anticoagulation.
Topics: Adenosine Monophosphate; Alanine; Ambulatory Care; Antibodies, Antiphospholipid; Antibodies, Monoclonal, Humanized; Anticoagulants; Antirheumatic Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Dose-Response Relationship, Drug; Drug Combinations; Duration of Therapy; Glucocorticoids; Hospitalization; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Ritonavir; SARS-CoV-2; Thrombolytic Therapy; Thrombophilia; Thrombosis; Venous Thromboembolism | 2021 |
Remdesivir for treatment of COVID-19; an updated systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pandemics; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
COVID-19: molecular pathophysiology, genetic evolution and prospective therapeutics-a review.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Serotherapy; Dexamethasone; Drug Repositioning; Evolution, Molecular; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Pandemics; Phylogeny; Prospective Studies; Pyrazines; Ribavirin; Ritonavir; SARS-CoV-2 | 2021 |
Major Update: Remdesivir for Adults With COVID-19 : A Living Systematic Review and Meta-analysis for the American College of Physicians Practice Points.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pneumonia, Viral; SARS-CoV-2 | 2021 |
The Era of the Coronavirus Disease 2019 Pandemic: A Review on Dynamics, Clinical Symptoms and Complications, Diagnosis, and Treatment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Evolution, Molecular; Global Burden of Disease; Humans; Hydroxychloroquine; Mutation; Off-Label Use; Pandemics; RNA, Viral; SARS-CoV-2; Severity of Illness Index | 2021 |
A Review on Remdesivir: A Broad-spectrum Antiviral Molecule for Possible COVID-19 Treatment.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2021 |
Coronavirus disease 2019 management.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Serotherapy; Dexamethasone; Humans; Immunization, Passive; Immunologic Factors; Patient Selection; Respiration, Artificial; SARS-CoV-2 | 2021 |
COVID-19 illness and autoimmune diseases: recent insights.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Arthritis, Rheumatoid; Autoimmune Diseases; Azetidines; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Dendritic Cells; Humans; Immune System; Immunity, Innate; Immunization, Passive; Inflammatory Bowel Diseases; Killer Cells, Natural; Lupus Erythematosus, Systemic; Monocytes; Multiple Sclerosis; Purines; Pyrazoles; Sulfonamides | 2021 |
Systematic Review and Patient-Level Meta-Analysis of SARS-CoV-2 Viral Dynamics to Model Response to Antiviral Therapies.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Female; Humans; Interferons; Male; Middle Aged; Proportional Hazards Models; SARS-CoV-2; Viral Load; Virus Shedding | 2021 |
[The praise of uncertainty: a systematic living review to evaluate the efficacy and safety of drug treatments for patients with covid-19.]
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Combined Modality Therapy; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Drug Repositioning; Humans; Hydroxychloroquine; Immunization, Passive; Immunoglobulins, Intravenous; Lopinavir; Mesenchymal Stem Cell Transplantation; Pandemics; Pyrazines; Randomized Controlled Trials as Topic; Ritonavir; SARS-CoV-2; Treatment Outcome; Uncertainty | 2021 |
Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project).
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Bromhexine; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Expectorants; Humans; Immunoglobulins, Intravenous; Respiration, Artificial; SARS-CoV-2; Treatment Outcome | 2021 |
A Comprehensive Review of Viral Characteristics, Transmission, Pathophysiology, Immune Response, and Management of SARS-CoV-2 and COVID-19 as a Basis for Controlling the Pandemic.
Topics: Adenosine Monophosphate; Aged; Alanine; Anti-Inflammatory Agents; Antigenic Variation; Antiviral Agents; Asymptomatic Diseases; Child; COVID-19; COVID-19 Vaccines; Dexamethasone; Humans; Immunity; Pandemics; SARS-CoV-2 | 2021 |
Pharmacological interventions for COVID-19: a systematic review of observational studies and clinical trials.
Topics: Adenosine Monophosphate; Alanine; Amides; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antimalarials; Antiviral Agents; Chloroquine; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Intensive Care Units; Length of Stay; Lopinavir; Methylprednisolone; Observational Studies as Topic; Patient Admission; Pyrazines; Ritonavir; SARS-CoV-2; Survival Rate | 2021 |
SARS-CoV-2: Insight in genome structure, pathogenesis and viral receptor binding analysis - An updated review.
Topics: Adenosine Monophosphate; Alanine; Animals; Chloroquine; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Genome, Viral; Humans; Receptors, Coronavirus; SARS-CoV-2; Virus Attachment | 2021 |
Clinical efficacy and safety of remdesivir in patients with COVID-19: a systematic review and network meta-analysis of randomized controlled trials.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome | 2021 |
A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Computational Biology; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Humans; Models, Molecular; Nucleosides; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2021 |
A metaresearch study revealed susceptibility of Covid-19 treatment research to white hat bias: first, do no harm.
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antiviral Agents; Azithromycin; Bias; COVID-19 Drug Treatment; Drug Therapy, Combination; Humans; Hydroxychloroquine; SARS-CoV-2 | 2021 |
COVID19 and acute lymphoblastic leukemias of children and adolescents: Updated recommendations (Version 2) of the Leukemia Committee of the French Society for the fight against Cancers and leukemias in children and adolescents (SFCE).
Topics: Adenosine Monophosphate; Adolescent; Adrenal Cortex Hormones; Alanine; Antiviral Agents; Cancer Care Facilities; Child; Consolidation Chemotherapy; COVID-19; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; COVID-19 Vaccines; Drug Interactions; France; Humans; Induction Chemotherapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Maintenance Chemotherapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Assessment; Societies, Medical | 2021 |
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor.
Topics: Adenosine; Adenosine Monophosphate; Adult; Alanine; Animals; Antiviral Agents; Area Under Curve; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Drug Interactions; Furans; Half-Life; Humans; Metabolic Clearance Rate; Pyrroles; SARS-CoV-2; Triazines | 2021 |
Hepatic transplant during SARS-CoV-2 (COVID-19) pandemic. A literature review.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azithromycin; Blood Component Transfusion; COVID-19; COVID-19 Serotherapy; Graft Rejection; Humans; Hydroxychloroquine; Immunization, Passive; Immunocompromised Host; Immunosuppressive Agents; Liver Transplantation; Pandemics; Waiting Lists; Withholding Treatment | 2021 |
Treatment of COVID-19: a review of current and prospective pharmacotherapies.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Anticoagulants; Antiviral Agents; Azetidines; Colchicine; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Dexamethasone; Glucocorticoids; Humans; Immunization, Passive; Immunologic Factors; Ivermectin; Janus Kinase Inhibitors; Platelet Aggregation Inhibitors; Purines; Pyrazoles; SARS-CoV-2; Sulfonamides | 2021 |
Mortality in mechanically ventilated patients with COVID-19: a systematic review.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; COVID-19; Humans; Respiration, Artificial; SARS-CoV-2; Treatment Outcome | 2021 |
Recent knowledge in favor of remdesivir (GS-5734) as a therapeutic option for the COVID-19 infections.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature.
Topics: Adenosine Monophosphate; Adult; Alanine; Antibodies, Monoclonal, Humanized; Anticoagulants; Antiviral Agents; COVID-19; Creatine Kinase; Critical Illness; Dexamethasone; Electromyography; Glucocorticoids; Heparin, Low-Molecular-Weight; Humans; Intensive Care Units; Magnetic Resonance Imaging; Male; Methicillin-Resistant Staphylococcus aureus; Muscle, Skeletal; Muscular Diseases; Neural Conduction; Pulmonary Embolism; Quadriplegia; Respiration, Artificial; Respiratory Distress Syndrome; SARS-CoV-2; Severity of Illness Index; Staphylococcal Infections; Ventilator Weaning | 2021 |
Insight in the Current Progress in the Largest Clinical Trials for Covid-19 Drug Management (As of January 2021).
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Chloroquine; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Dexamethasone; Drug Combinations; Glucocorticoids; Humans; Hydroxychloroquine; Immunization, Passive; Immunologic Factors; Lopinavir; Ritonavir; SARS-CoV-2 | 2021 |
Broad-Spectrum Antiviral Strategies and Nucleoside Analogues.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antiviral Agents; COVID-19 Drug Treatment; Hemorrhagic Fever, Ebola; Humans; Middle East Respiratory Syndrome Coronavirus; Mutagenesis; Nucleosides; Pyrazines; Ribavirin; SARS-CoV-2; Virus Replication; Zika Virus; Zika Virus Infection | 2021 |
What if COVID-19 affects the child: which weapons and how to use them.
Topics: Adenosine Monophosphate; Adolescent; Age Factors; Alanine; Antibodies, Monoclonal, Humanized; Anticoagulants; Antiviral Agents; Carrier State; Child; Child, Preschool; Chloroquine; Continuous Renal Replacement Therapy; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Extracorporeal Membrane Oxygenation; Glucocorticoids; Humans; Hydroxychloroquine; Immunization, Passive; Immunoglobulins, Intravenous; Immunologic Factors; Infant; Infant, Newborn; Interferon-alpha; Lopinavir; Oseltamivir; Receptors, Cell Surface; Respiration, Artificial; Ribavirin; Ritonavir; SARS-CoV-2; Severity of Illness Index; Thrombosis | 2021 |
[COVID-19: From a clinician's perspective.]
Topics: Adenosine Monophosphate; Alanine; COVID-19; Disease Progression; Extracorporeal Membrane Oxygenation; Female; Humans; Male; Polymerase Chain Reaction; Risk Factors; SARS-CoV-2; Sputum; Time Factors | 2020 |
Remdesivir for coronavirus disease 2019 (COVID-19): a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2021 |
Management of COVID-19 in patients with seizures: Mechanisms of action of potential COVID-19 drug treatments and consideration for potential drug-drug interactions with anti-seizure medications.
Topics: Adenosine Monophosphate; Alanine; Amides; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Anticonvulsants; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A Inducers; Dexamethasone; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Epilepsy; Glucocorticoids; Humans; Hydroxychloroquine; Interleukin 1 Receptor Antagonist Protein; Ivermectin; Lopinavir; Pyrazines; Ritonavir; SARS-CoV-2 | 2021 |
Safety and Efficacy of Remdesivir for the Treatment of COVID-19: A Systematic Review and Meta-Analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Hypoalbuminemia; Hypokalemia; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Remdesivir for the treatment of Covid-19: the value of biochemical studies.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Humans; Prodrugs; RNA, Viral; SARS-CoV-2; Substrate Specificity; Virus Replication | 2021 |
Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Azithromycin; COVID-19; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; SARS-CoV-2; Vitamin D | 2021 |
Efficacy and safety of remdesivir in COVID-19 caused by SARS-CoV-2: a systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Sinus Bradycardia in a Pediatric Patient Treated With Remdesivir for Acute Coronavirus Disease 2019: A Case Report and a Review of the Literature.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bradycardia; Child; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
The use of remdesivir for the management of patients with moderate-to-severe COVID-19: a systematic review.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Clinical Trials, Phase III as Topic; COVID-19 Drug Treatment; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Trends in the development of remdesivir based inventions against COVID-19 and other disorders: A patent review.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Inventions; SARS-CoV-2; Saudi Arabia | 2021 |
Clinical efficacy of antiviral agents against coronavirus disease 2019: A systematic review of randomized controlled trials.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Carbamates; Cobicistat; COVID-19 Drug Treatment; Darunavir; Dibenzothiepins; Drug Combinations; Drug Therapy, Combination; Humans; Imidazoles; Indoles; Iran; Lopinavir; Morpholines; Pyrazines; Pyridones; Pyrrolidines; Randomized Controlled Trials as Topic; Ritonavir; SARS-CoV-2; Sofosbuvir; Treatment Outcome; Triazines; Valine | 2021 |
Synthetic Attempts Towards Eminent Anti-viral Candidates of SARS-CoV.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Lopinavir; Pyrazines; SARS-CoV-2 | 2022 |
A Meta-Analysis of Safety of Different Regimens of Remdesivir in COVID-19 Patients.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans | 2022 |
Efficacy and safety of remdesivir in hospitalised COVID-19 patients: a systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Should we be concerned when COVID-19-positive patients take opioids to control their pain? Insights from a pharmacological point of view.
Topics: Adenosine Monophosphate; Alanine; Analgesics, Opioid; Anti-Inflammatory Agents; Antiviral Agents; Chronic Pain; COVID-19 Drug Treatment; Dexamethasone; Drug Interactions; Humans; SARS-CoV-2 | 2021 |
Remdesivir for the treatment of COVID 19: review of the pharmacological properties, safety and clinical effectiveness.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome; Virus Replication | 2021 |
Remdesivir for the treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bias; Cause of Death; Confidence Intervals; COVID-19; COVID-19 Drug Treatment; Disease Progression; Humans; Middle Aged; Oxygen; Randomized Controlled Trials as Topic; Respiration, Artificial; SARS-CoV-2; Ventilator Weaning | 2021 |
Possible Therapeutic Potential of Cysteinyl Leukotriene Receptor Antagonist Montelukast in Treatment of SARS-CoV-2-Induced COVID-19.
Topics: Acetates; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cyclopropanes; Humans; Leukotriene Antagonists; Quinolines; Receptors, Leukotriene; Sulfides | 2021 |
What is the role of remdesivir in patients with COVID-19?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Clinical Efficacy of Remdesivir and Favipiravir in the Treatment of COVID-19 Patients: Scenario so far.
Topics: Adenosine Monophosphate; Alanine; Amides; COVID-19 Drug Treatment; Humans; Pyrazines; SARS-CoV-2; Treatment Outcome | 2022 |
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Humans; Phosphorylation; Prodrugs; SARS-CoV-2 | 2021 |
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Genetic Structures; Humans; Pandemics; SARS-CoV-2; Vaccination | 2021 |
An overview of the preclinical discovery and development of remdesivir for the treatment of coronavirus disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
A review of remdesivir for COVID-19 in pregnancy and lactation.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Breast Feeding; COVID-19 Drug Treatment; Female; Humans; Lactation; Pandemics; Pregnancy; Pregnancy Complications, Infectious; SARS-CoV-2 | 2021 |
COVID-19: potential therapeutics for pediatric patients.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azithromycin; Child; COVID-19 Drug Treatment; Dexamethasone; Humans; Hydroxychloroquine; Ivermectin; Lopinavir; Oseltamivir; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2021 |
Biology of COVID-19 and related viruses: Epidemiology, signs, symptoms, diagnosis, and treatment.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Animals; Antiviral Agents; Coronavirus; Cough; COVID-19; Diabetes Mellitus; Fatigue; Fever; Heart Diseases; Humans; Positive-Pressure Respiration; Prognosis; Pulmonary Disease, Chronic Obstructive; SARS-CoV-2; Treatment Outcome | 2021 |
Remdesivir: A Closer Look at Its Effect in COVID-19 Pandemic.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2021 |
COVID-19: The Disease, the Immunological Challenges, the Treatment with Pharmaceuticals and Low-Dose Ionizing Radiation.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Humans; Pandemics; Radiation, Ionizing; Radiotherapy; SARS-CoV-2; X-Ray Therapy | 2021 |
Potential Cardiotoxic Effects of Remdesivir on Cardiovascular System: A Literature Review.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cardiotoxicity; Cardiovascular System; COVID-19 Drug Treatment; Humans | 2022 |
Prediction of in-hospital mortality with machine learning for COVID-19 patients treated with steroid and remdesivir.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Hospital Mortality; Humans; Machine Learning; Steroids | 2022 |
Current treatment strategies for COVID‑19 (Review).
Topics: Adenosine Monophosphate; Alanine; Animals; Antimalarials; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Serotherapy; Drugs, Chinese Herbal; Humans; Hydroxychloroquine; Immunization, Passive; SARS-CoV-2 | 2021 |
Association and pharmacological synergism of the triple drug therapy baricitinib/remdesivir/rhACE2 for the management of COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Azetidines; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Disease Management; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Purines; Pyrazoles; Sulfonamides | 2022 |
Remdesivir: Quo vadis?
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Humans; Protein Structure, Tertiary; SARS-CoV-2 | 2021 |
Mechanisms of inhibition of viral RNA replication by nucleotide analogs.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; Hepatitis C, Chronic; Humans; Kinetics; Nucleotides; RNA, Viral; SARS-CoV-2 | 2021 |
Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Datasets as Topic; Drug Development; Drug Repositioning; Host-Pathogen Interactions; Humans; Metabolic Networks and Pathways; Pandemics; RNA, Small Interfering; SARS-CoV-2; Sequence Analysis, RNA; Vero Cells | 2021 |
Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents.
Topics: Adenosine Monophosphate; Alanine; Amides; COVID-19 Drug Treatment; Humans; Pyrazines; RNA, Viral; SARS-CoV-2 | 2022 |
Use of remdesivir in children with COVID-19 infection: a quick narrative review.
Topics: Adenosine Monophosphate; Adult; Alanine; Child; COVID-19 Drug Treatment; Humans; Infant, Newborn; SARS-CoV-2 | 2021 |
Protocol: Benefits and harms of remdesivir for COVID-19 in adults: A systematic review with meta-analysis.
Topics: Adenosine Monophosphate; Adult; Alanine; COVID-19 Drug Treatment; Humans; Publication Bias; Risk | 2021 |
Therapeutic dilemmas in addressing SARS-CoV-2 infection: Favipiravir versus Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrazines; SARS-CoV-2 | 2022 |
Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp).
Topics: Adenosine Monophosphate; Alanine; Amides; Catalytic Domain; Computational Biology; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Pyrazines; Pyrimidines; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Triazoles; Virus Replication | 2022 |
COVID-19 in Children.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Child; COVID-19; Glucocorticoids; Hospitalization; Humans; Immunoglobulins, Intravenous; Systemic Inflammatory Response Syndrome | 2022 |
Major Update 2: Remdesivir for Adults With COVID-19: A Living Systematic Review and Meta-analysis for the American College of Physicians Practice Points.
Topics: Adenosine Monophosphate; Adult; Alanine; COVID-19 Drug Treatment; Humans; Physicians; United States | 2022 |
Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Drug Combinations; Humans; Hydroxychloroquine; Lopinavir; Randomized Controlled Trials as Topic; Ritonavir; SARS-CoV-2 | 2022 |
Is the efficacy of remdesivir so different from that of lopinavir-ritonavir in severe COVID-19? The answer by real time-PCR: a narrative review.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Lopinavir; Polymerase Chain Reaction; Ritonavir; SARS-CoV-2; Treatment Outcome | 2021 |
The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infections.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Drug Development; Hemorrhagic Fevers, Viral; Humans; Medical Countermeasures; Models, Animal; Primates; RNA Virus Infections; United States; United States Food and Drug Administration | 2022 |
Efficacy of early use of remdesivir: a systematic review of subgroup analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans | 2022 |
Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Virus Replication | 2022 |
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Interferon beta-1a; Lopinavir; Oxygen; Randomized Controlled Trials as Topic; Treatment Outcome; World Health Organization | 2022 |
Remdesivir for the treatment of COVID-19: a systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Adult; Alanine; Bayes Theorem; COVID-19 Drug Treatment; Humans; Oxygen; SARS-CoV-2; United States | 2022 |
Treatment strategies of COVID-19: A rheumatology perspective.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal; COVID-19 Drug Treatment; Critical Illness; Cytokine Release Syndrome; Cytokines; Humans; Rheumatology; SARS-CoV-2 | 2022 |
Remdesivir and Its Combination With Repurposed Drugs as COVID-19 Therapeutics.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2022 |
Remdesivir: an overview of patenting trends, clinical evidence on COVID-19 treatment, pharmacology and chemistry.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Hospitalization; Humans | 2022 |
Mapping Scientific Productivity Trends and Hotspots in Remdesivir Research Publications: A Bibliometric Study from 2016 to 2021.
Topics: Adenosine Monophosphate; Alanine; Bibliometrics; Databases, Factual; Efficiency; Global Health; Publications | 2022 |
47 trial(s) available for alanine and adenosine monophosphate
| Article | Year |
|---|---|
Randomised controlled trial begins for Ebola therapeutics.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Child, Preschool; Democratic Republic of the Congo; Ebolavirus; Feasibility Studies; Female; Hemorrhagic Fever, Ebola; Humans; Infant; Infant, Newborn; Male; Ribonucleotides; Treatment Outcome | 2018 |
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.
Topics: Adenosine Monophosphate; Adolescent; Adult; Alanine; Antibodies, Monoclonal; Antiviral Agents; Child; Child, Preschool; Democratic Republic of the Congo; Disease Outbreaks; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Male; Ribonucleotides; RNA, Viral; Single-Blind Method; Young Adult | 2019 |
Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post-treatment hospitalisation status.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; Female; Hospitalization; Humans; Intensive Care Units; Male; Middle Aged; Pandemics; Pneumonia, Viral; SARS-CoV-2; Transaminases; Treatment Outcome | 2020 |
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; China; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Negative Results; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir for the Treatment of Covid-19 - Final Report.
Topics: Adenosine Monophosphate; Administration, Intravenous; Adult; Aged; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Extracorporeal Membrane Oxygenation; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Oxygen Inhalation Therapy; Pandemics; Pneumonia, Viral; Respiration, Artificial; SARS-CoV-2; Time Factors; Young Adult | 2020 |
Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; China; Clinical Trials, Phase III as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Equivalence Trials as Topic; Female; Humans; Infusions, Intravenous; Male; Multicenter Studies as Topic; Pandemics; Patient Safety; Pneumonia, Viral; Risk Assessment; Risk Factors; SARS-CoV-2; Severity of Illness Index; Time Factors; Treatment Outcome | 2020 |
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Administration Schedule; Female; Hospitalization; Humans; Male; Middle Aged; Oxygen Inhalation Therapy; Pandemics; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID-19, in Healthy Subjects.
Topics: Adenosine Monophosphate; Administration, Intravenous; Adult; Alanine; Antiviral Agents; Area Under Curve; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Female; Healthy Volunteers; Humans; Japan; Male; Middle Aged; Pandemics; Pneumonia, Viral; SARS-CoV-2; Young Adult | 2020 |
Remdesivir for Severe Coronavirus Disease 2019 (COVID-19) Versus a Cohort Receiving Standard of Care.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Cohort Studies; COVID-19 Drug Treatment; Humans; Oxygen Saturation; Retrospective Studies; SARS-CoV-2; Standard of Care; Treatment Outcome | 2021 |
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial.
Topics: Adenosine Monophosphate; Administration, Intravenous; Aged; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Administration Schedule; Female; Hospitalization; Humans; Male; Middle Aged; Odds Ratio; Pandemics; Patient Acuity; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Drug Therapy, Combination; Early Warning Score; Extracorporeal Membrane Oxygenation; Hospital Mortality; Hospitalization; Humans; Hydroxychloroquine; Interferon beta-1a; Length of Stay; Lopinavir; Oxygen Inhalation Therapy; Pandemics; Pneumonia, Viral; Respiration, Artificial; Ritonavir; SARS-CoV-2; Standard of Care; Treatment Outcome | 2020 |
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Female; Hospital Mortality; Hospitalization; Humans; Hydroxychloroquine; Intention to Treat Analysis; Interferon beta-1a; Kaplan-Meier Estimate; Length of Stay; Lopinavir; Male; Middle Aged; Respiration, Artificial; Treatment Failure | 2021 |
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; Azetidines; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Drug Therapy, Combination; Female; Hospital Mortality; Hospitalization; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Oxygen Inhalation Therapy; Purines; Pyrazoles; Respiration, Artificial; Sulfonamides; Treatment Outcome | 2021 |
Remdesivir in The Treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Double-Blind Method; Female; Humans; Male; Middle Aged | 2021 |
A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Hospitalization; Humans; Intention to Treat Analysis; Male; Middle Aged; Treatment Failure | 2021 |
PREVAIL IV: A Randomized, Double-Blind, 2-Phase, Phase 2 Trial of Remdesivir vs Placebo for Reduction of Ebola Virus RNA in the Semen of Male Survivors.
Topics: Adenosine Monophosphate; Alanine; Double-Blind Method; Ebolavirus; Female; Follow-Up Studies; Hemorrhagic Fever, Ebola; Humans; Male; RNA; Semen; Survivors | 2021 |
Liver and kidney function in patients with Covid-19 treated with remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Kidney; Liver; Retrospective Studies; SARS-CoV-2; Treatment Outcome | 2021 |
Race and ethnicity do not impact eligibility for remdesivir: A single-center experience.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Alanine; Antiviral Agents; Black or African American; COVID-19 Drug Treatment; Delivery of Health Care; Eligibility Determination; Female; Hispanic or Latino; Humans; Male; Middle Aged; Minority Groups; SARS-CoV-2; United States; White People; Young Adult | 2021 |
Favipiravir use in children with COVID-19 and acute kidney injury: is it safe?
Topics: Acute Kidney Injury; Adenosine Monophosphate; Adolescent; Alanine; Amides; Child; COVID-19; COVID-19 Drug Treatment; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Male; Pyrazines; Renal Elimination; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2021 |
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Viral; Antiviral Agents; Biomarkers; Cause of Death; COVID-19; COVID-19 Drug Treatment; Female; Hospital Mortality; Humans; Hydroxychloroquine; Inflammation; Male; Middle Aged; Norway; Oropharynx; Respiratory Insufficiency; SARS-CoV-2; Severity of Illness Index; Standard of Care; Treatment Outcome; Viral Load | 2021 |
Successful early treatment combining remdesivir with high-titer convalescent plasma among COVID-19-infected hematological patients.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Czech Republic; Female; Follow-Up Studies; Hematologic Neoplasms; Humans; Immunization, Passive; Male; Middle Aged; Prognosis; Retrospective Studies; SARS-CoV-2 | 2021 |
Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Critical Care; Humans; Oxygen; SARS-CoV-2 | 2022 |
Evaluation of adalimumab effects in managing severe cases of COVID-19: A randomized controlled trial.
Topics: Adalimumab; Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Dexamethasone; Drug Therapy, Combination; Female; Humans; Middle Aged; Pregnancy; Respiration, Artificial | 2021 |
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Adult; Alanine; Antiviral Agents; Asia; Azetidines; COVID-19 Drug Treatment; Dexamethasone; Double-Blind Method; Europe; Humans; North America; Purines; Pyrazoles; SARS-CoV-2; South America; Sulfonamides; Treatment Outcome | 2021 |
Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Europe; Extracorporeal Membrane Oxygenation; Female; Hospitalization; Humans; Male; Middle Aged; Oxygen; Respiration, Artificial; Standard of Care | 2022 |
Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antimetabolites; Antiviral Agents; COVID-19 Drug Treatment; Humans | 2021 |
RETRACTED: Remdesivir Efficacy in COVID-19 Treatment: A Randomized Controlled Trial.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Double-Blind Method; Female; Humans; Interferon beta-1a; Japan; Male; Mexico; Middle Aged; Oxygen; Oxygen Saturation; Republic of Korea; SARS-CoV-2; Singapore; Treatment Outcome; United States | 2021 |
An open-label, randomized, single intravenous dosing study to investigate the effect of fixed-dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR).
Topics: Adenosine Monophosphate; Adult; Alanine; Anti-HIV Agents; Atazanavir Sulfate; Healthy Volunteers; Humans; Lamivudine; Oligopeptides; Pyridines; Ritonavir; Tenofovir; Uganda | 2021 |
The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial.
Topics: Adenosine Monophosphate; Alanine; Amides; Antioxidants; Antiviral Agents; Biomarkers; COVID-19; COVID-19 Drug Treatment; Drug Monitoring; Female; Hemoglobins; Humans; Male; Middle Aged; Outcome and Process Assessment, Health Care; Patient Discharge; Pyrazines; Quercetin; Respiratory Rate | 2022 |
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Adult; Alanine; Antibodies, Monoclonal; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Disease-Free Survival; Double-Blind Method; Female; Humans; Male; Middle Aged; Respiratory Distress Syndrome; SARS-CoV-2; Survival Rate; Tumor Necrosis Factor Ligand Superfamily Member 14 | 2022 |
Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.
Topics: Adenosine Monophosphate; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antigens, Viral; Antiviral Agents; Biomarkers; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Medical Futility; Middle Aged; RNA, Viral; SARS-CoV-2; Treatment Failure | 2022 |
Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Alanine; Antiviral Agents; Comorbidity; COVID-19; COVID-19 Drug Treatment; Disease Progression; Double-Blind Method; Female; Hospitalization; Humans; Male; Middle Aged; Outpatients; SARS-CoV-2; Time-to-Treatment; Viral Load | 2022 |
Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Canada; Comorbidity; COVID-19; COVID-19 Drug Treatment; Female; Hospital Mortality; Humans; Length of Stay; Male; Middle Aged; Pandemics; Respiration, Artificial; SARS-CoV-2 | 2022 |
An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19.
Topics: Adenosine Monophosphate; Aged; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Double-Blind Method; Drug Approval; Drug Combinations; Female; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Male; Middle Aged; Nitriles; Proline; Ritonavir; SARS-CoV-2; Severity of Illness Index; Treatment Outcome | 2022 |
Remdesivir Plus Dexamethasone Versus Dexamethasone Alone for the Treatment of Coronavirus Disease 2019 (COVID-19) Patients Requiring Supplemental O2 Therapy: A Prospective Controlled Nonrandomized Study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Dexamethasone; Humans; Prospective Studies; SARS-CoV-2 | 2022 |
Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Neutralizing; Antiviral Agents; COVID-19; COVID-19 Vaccines; Double-Blind Method; Female; Hospitalization; Humans; Inpatients; Internationality; Male; Middle Aged; Treatment Outcome; Vaccines, Inactivated | 2022 |
Remdesivir and Human Milk: A Case Study.
Topics: Adenosine Monophosphate; Adult; Alanine; Breast Feeding; COVID-19 Drug Treatment; Female; Humans; Infant; Milk, Human; SARS-CoV-2 | 2022 |
Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Remdesivir in Coronavirus Disease 2019 patients treated with anti-CD20 monoclonal antibodies: a case series.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Humans; Immunization, Passive; Recurrence; SARS-CoV-2; Treatment Outcome | 2022 |
In adults hospitalized with COVID-19, adding remdesivir to standard care did not reduce in-hospital mortality.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Hospital Mortality; Humans; SARS-CoV-2 | 2022 |
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans | 2022 |
Real-world effectiveness of early remdesivir and sotrovimab in the highest-risk COVID-19 outpatients during the Omicron surge.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; COVID-19 Drug Treatment; Humans; Outpatients; Retrospective Studies; SARS-CoV-2 | 2022 |
Remdesivir in Patients With Severe Kidney Dysfunction: A Secondary Analysis of the CATCO Randomized Trial.
Topics: Adenosine Monophosphate; Alanine; Humans; Kidney; Kidney Diseases | 2022 |
In adults hospitalized with COVID-19, adding baricitinib vs. dexamethasone to remdesivir did not differ for MV-free survival.
Topics: Adenosine Monophosphate; Adult; Alanine; Azetidines; COVID-19 Drug Treatment; Dexamethasone; Double-Blind Method; Humans; Purines; Pyrazoles; Sulfonamides | 2022 |
Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1).
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Child; COVID-19; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2023 |
Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants.
Topics: Adenosine Monophosphate; Adult; Alanine; Dose-Response Relationship, Drug; Double-Blind Method; Healthy Volunteers; Humans | 2023 |
811 other study(ies) available for alanine and adenosine monophosphate
| Article | Year |
|---|---|
Influence of anoxia on the energy metabolism of goldfish Carassius auratus (L.).
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Animals; Carbon Dioxide; Creatine; Cyprinidae; Energy Metabolism; Fatty Acids; Glutamates; Goldfish; Hypoxia; Lactates; Muscles; Phosphocreatine; Species Specificity | 1976 |
Inorganic nitrogen assimilation by the photosynthetic bacterium Rhodopseudomonas capsulata.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Oxidoreductases; Ammonia; Glutamate Dehydrogenase; Glutamate Synthase; Glutamate-Ammonia Ligase; Kinetics; Methionine Sulfoximine; Nitrogen; Rhodopseudomonas | 1976 |
The mechanism of clay catalyzed polymerization of amino acid adenylates.
Topics: Adenosine Monophosphate; Adsorption; Alanine; Catalysis; Hydrogen-Ion Concentration; Minerals; Peptides; Structure-Activity Relationship | 1977 |
The influence of various cations on the catalytic properties of clays.
Topics: Adenosine Monophosphate; Alanine; Aluminum Silicates; Catalysis; Cations; Hydrogen-Ion Concentration; Lysine; Minerals; Molecular Weight; Peptides | 1978 |
Regulation of the activity of mung bean (Phaseolus aureus) glutamine synthetase by amino acids and nucleotides.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Amino Acids; Binding, Competitive; Glutamate-Ammonia Ligase; Glycine; Histidine; Kinetics; Plants | 1979 |
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate.
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Aspartic Acid; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Glucose; Hypoxanthines; Inosine Nucleotides; Liver Neoplasms; Mengovirus; Neoplasm Proteins; Neoplasms, Experimental; Nitroso Compounds; Purine Nucleotides; Pyrimidine Nucleotides; RNA, Neoplasm; Succinates; Uracil Nucleotides; Uridine | 1976 |
Synthesis of amino acyl adenylates using the tert-butoxycarbonyl protecting group.
Topics: Adenosine Monophosphate; Alanine; Amino Acids; Aminoacylation; Chemical Phenomena; Chemistry; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methionine; Methods; Phenylalanine; Spectrophotometry, Infrared | 1979 |
The purine nucleotide cycle. Studies of ammonia production by skeletal muscle in situ and in perfused preparations.
Topics: Adenosine Monophosphate; Alanine; Ammonia; Animals; Citrates; Cyanides; Epinephrine; Glutamine; Glycolysis; Hypoxanthines; Hypoxia; Inosine Nucleotides; Malates; Male; Muscles; Perfusion; Physical Exertion; Purine Nucleotides; Rats; Succinates | 1977 |
His92Ala mutation in ribonuclease T1 induces segmental flexibility. An X-ray study.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Sequence; Catalysis; Cysteine; Guanine; Guanosine Monophosphate; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Ribonuclease T1; Structure-Activity Relationship; Temperature; Valine; X-Ray Diffraction | 1992 |
Activation of methionine by Escherichia coli methionyl-tRNA synthetase.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Sequence; Arginine; Aspartic Acid; Bacterial Proteins; Base Sequence; Catalysis; Enzyme Activation; Escherichia coli; Glutamine; Methionine; Methionine-tRNA Ligase; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Substrate Specificity; Transfer RNA Aminoacylation; Tryptophan | 1991 |
Comparison of alanine production after L-leucine and AMP deamination in an enzymatic model and in muscle specimens.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Oxidoreductases; AMP Deaminase; Animals; Deamination; In Vitro Techniques; Leucine Dehydrogenase; Models, Biological; Muscles; Nucleotide Deaminases; Rats | 1990 |
Regulation and properties of the glutamine synthetase purified from Photobacterium phosphoreum.
Topics: Adenosine Monophosphate; Alanine; Catalysis; Cations, Divalent; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Hydrogen-Ion Concentration; Molecular Weight; Photobacterium; Serine; Spectrophotometry, Ultraviolet | 1986 |
Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity.
Topics: Acylation; Adenosine Monophosphate; Alanine; Alanine-tRNA Ligase; Amino Acyl-tRNA Synthetases; Base Sequence; Cloning, Molecular; Codon; Escherichia coli; Genes; Genes, Bacterial; Molecular Weight; Mutation; Plasmids; Transformation, Bacterial | 1985 |
Purification and properties of rat brain pyruvate kinase.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Animals; Brain; Calcium; Chromatography; Electrophoresis, Polyacrylamide Gel; Female; Fructosediphosphates; Hydrogen-Ion Concentration; Kinetics; Phenylalanine; Pyruvate Kinase; Rats; Rats, Inbred Strains; Substrate Specificity | 1985 |
[Effect of a pyruvate injection on liver metabolism in the rat].
Topics: Acetone; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Animals; Aspartic Acid; Citrates; Glutamates; Glycerophosphates; Ketoglutaric Acids; Liver; Male; Metabolism; Models, Chemical; NADP; Phosphates; Phosphoric Acids; Pyruvates; Rats; Time Factors; Trioses; Urea | 1971 |
[Effect of the simultaneous administration of pyruvate and ethanol on liver metabolism in the rat].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Animals; Aspartic Acid; Citrates; Drug Synergism; Ethanol; Glutamates; Ketoglutaric Acids; Liver; Male; Metabolism; Models, Chemical; NADP; Oxidation-Reduction; Phosphates; Pyruvates; Rats; Time Factors; Urea | 1971 |
Studies on the enzymes involved in the biosynthesis of cyclo-tris (N-2,3-dihydroxybenzoyl-L-seryl) in Escherichia coli: kinetic properties of the L-serine-activating enzyme.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Anti-Bacterial Agents; Drug Stability; Enzyme Induction; Escherichia coli; Ethylmaleimide; Glycine; Gramicidin; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Phosphates; Phosphorus Radioisotopes; Proline; Serine; Threonine; Time Factors; Tritium; Tyrosine | 1973 |
Regulation of glutamine synthetase from Bacillus subtilis by divalent cations, feedback inhibitors, and L-glutamine.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Ammonia; Bacillus subtilis; Feedback; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Glycine; Histidine; Kinetics; Magnesium; Manganese; Tryptophan | 1974 |
Feedback inhibition of glutamine synthetase from green pea seeds.
Topics: Adenosine Monophosphate; Alanine; Animals; Chromatography, Gel; Escherichia coli; Glutamate-Ammonia Ligase; Glycine; Histidine; Kinetics; Liver; Plants; Rats; Seeds; Species Specificity; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Tryptophan | 1974 |
Some properties of glutamine synthetase from baker's yeast.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Amino Acids; Cations, Divalent; Electrophoresis; Glutamate-Ammonia Ligase; Glutamates; Glycine; Histidine; Molecular Weight; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Tryptophan; Ultracentrifugation | 1974 |
Formation of D-alanyl-D-alanine and D-alanine from UDPMurNAc-L-Ala-D-isoGlu-L-Lys-D-Ala-D-Ala by extracts of Staphylococcus aureus and Streptococcus faecalis.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Carbon Radioisotopes; Chromatography, Paper; Dipeptides; Enterococcus faecalis; Muramic Acids; Oligopeptides; Penicillin G; Peptide Synthases; Phosphates; Serine; Species Specificity; Staphylococcus; Sugar Acids; Uracil Nucleotides | 1974 |
Rabbit liver fructose 1,6-diphosphatase. Properties of the native enzyme and their modification by subtilisin.
Topics: Adenosine Monophosphate; Alanine; Amino Acids; Ammonium Sulfate; Animals; Carboxypeptidases; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography, Ion Exchange; Electrophoresis; Endopeptidases; Fructose-Bisphosphatase; Fructosephosphates; Hydrogen-Ion Concentration; Liver; Macromolecular Substances; Molecular Weight; Rabbits; Sodium Dodecyl Sulfate; Tryptophan; Ultracentrifugation | 1972 |
Some properties of a homocarnosine-carnosine synthetase isolated from rat brain.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Aminobutyrates; Ammonium Sulfate; Animals; Brain; Carbon Radioisotopes; Chromatography; Chromatography, Paper; Dialysis; Dipeptides; Diphosphates; Electrophoresis, Paper; Female; Histidine; Hydrogen-Ion Concentration; NAD; Nerve Tissue Proteins; Peptide Synthases; Peptides; Rats | 1973 |
Bacillus subtilis glutamine synthetase. Dependence of -glutamyltransferase activity on ionic strength and specific monovalent cations.
Topics: Adenosine Monophosphate; Alanine; Arsenic; Bacillus subtilis; Catalysis; Enzyme Activation; Feedback; Glutamate-Ammonia Ligase; Glycine; Hydroxylamines; Lithium; Macromolecular Substances; Magnesium; Manganese; Naphthalenes; Osmolar Concentration; Potassium; Rubidium; Scattering, Radiation; Sodium; Spectrometry, Fluorescence; Sulfonic Acids; Tryptophan; Ultracentrifugation | 1972 |
Effects of cobaltous ion on various catalytic parameters and on heterologous subunit interactions of Escherichia coli glutamine synthetase.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Catalysis; Cobalt; Colorimetry; Cytosine Nucleotides; Enzyme Activation; Escherichia coli; Feedback; Glutamate-Ammonia Ligase; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Macromolecular Substances; Magnesium; Manganese; Models, Structural; Quaternary Ammonium Compounds; Tryptophan | 1972 |
The effect of tryptophan administration on fatty acid synthesis in the liver of the fasted normal rat.
Topics: Acetates; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Animals; Carbon Radioisotopes; Cholesterol; Chromatography, Thin Layer; Citric Acid Cycle; Fasting; Fatty Acids; Fatty Acids, Nonesterified; Glycerol; Intestine, Small; Lipids; Liver; Male; Phospholipids; Pyruvate Dehydrogenase Complex; Quinolines; Rats; Time Factors; Triglycerides; Tritium; Tryptophan; Water | 1974 |
Phenethylbiguanide and the inhibition of hepatic gluconeogenesis in the guinea pig.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Alanine; Animals; Cell Fractionation; Gluconeogenesis; Glycerides; Guinea Pigs; Ketoglutaric Acids; Kinetics; Lactates; Malates; Mitochondria, Liver; Oxygen Consumption; Perfusion; Phenformin; Phosphoenolpyruvate; Pyruvates; Rats; Time Factors | 1974 |
The synthesis of taurine from sulfate. V. Regulatory modifiers of the chick liver enzyme system.
Topics: Adenosine Monophosphate; Alanine; Allosteric Regulation; Animals; Chickens; Cysteine; Ethionine; Homocysteine; Liver; Methionine; Organophosphorus Compounds; S-Adenosylmethionine; Serine; Sulfinic Acids; Sulfonic Acids; Sulfur Radioisotopes; Sulfuric Acids; Sulfurtransferases; Taurine | 1973 |
Regulation of the activity of the Bacillus licheniformis A5 glutamine synthetase.
Topics: Adenosine Monophosphate; Alanine; Allosteric Site; Bacillus; Binding Sites; Glutamate-Ammonia Ligase; Glutamine; Phosphoribosyl Pyrophosphate | 1981 |
Ab-initio refinement of an orbital-centred force field for biomolecules. Test cases including peptides, a sulphonamide and modelling of DNA helices.
Topics: Adenosine Monophosphate; Alanine; Dipeptides; DNA; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Protein Conformation; Quantum Theory; Sulfonamides | 1982 |
Studies on the mechanism of resistance of selected murine tumors to L-alanosine.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibiotics, Antineoplastic; DNA; Drug Resistance; Leukemia L1210; Leukemia P388; Male; Mice; Neoplasms, Experimental; Nerve Tissue Proteins; Nitrosamines; Peptide Synthases; Succinates | 1981 |
Fructose-1,6-bisphosphatase: arginine-22 is involved in stabilization of the T allosteric state.
Topics: Adenosine Monophosphate; Alanine; Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Arginine; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Fructose-Bisphosphatase; Kidney; Kinetics; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Proteins; Swine | 1995 |
Effect of acetyl-L-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat--study by 13P- and 1H-NMR spectroscopy.
Topics: Acetylcarnitine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Analysis of Variance; Animals; Brain; Creatine; Energy Metabolism; Glycerophosphates; Hydrogen; Ischemic Attack, Transient; Lactates; Magnetic Resonance Spectroscopy; Male; Phosphates; Phosphocreatine; Phosphorus; Rats; Rats, Inbred F344; Reference Values; Reperfusion | 1994 |
Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells.
Topics: Adenosine Monophosphate; Alanine; Amino Acids; Animals; Arachidonic Acid; Ascorbic Acid; Aspartic Acid; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Chick Embryo; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Iron; Membrane Potentials; Neurotoxins; Oxidative Stress; Retina; Taurine; Tritium | 1996 |
Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding.
Topics: Adenosine Monophosphate; Alanine; Allosteric Regulation; Animals; Aspartic Acid; Binding Sites; Caffeine; Crystallization; Glucose; Glucosephosphates; Kinetics; Muscles; Mutagenesis, Site-Directed; Phosphorylases; Protein Conformation; Rabbits; Structure-Activity Relationship | 1996 |
Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy.
Topics: Adenosine Monophosphate; Alanine; Antimetabolites, Antineoplastic; Chromosomes, Human, Pair 9; DNA Mutational Analysis; DNA, Neoplasm; Exons; Genes; Genes, Tumor Suppressor; Humans; Leukemia-Lymphoma, Adult T-Cell; Methionine; Neoplasm Proteins; Polymerase Chain Reaction; Purine-Nucleoside Phosphorylase; Sequence Deletion; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
Topics: Adenosine Monophosphate; Alanine; Animals; Anti-HIV Agents; Antiviral Agents; Cell Line; Cells, Cultured; Dideoxyadenosine; Hepatitis B virus; HIV; Humans; Leukocytes, Mononuclear; Macrophages; Molecular Structure; Moloney murine sarcoma virus; Simian Immunodeficiency Virus; Transfection; Tumor Cells, Cultured | 1997 |
Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro.
Topics: Adenosine Monophosphate; Alanine; Antibiotics, Antineoplastic; Humans; Leukemia-Lymphoma, Adult T-Cell; Polymerase Chain Reaction; Purine-Nucleoside Phosphorylase; Thymidine | 1999 |
Mutations in the hinge of a dynamic loop broadly influence functional properties of fructose-1,6-bisphosphatase.
Topics: Adenosine Monophosphate; Alanine; Allosteric Regulation; Animals; Catalytic Domain; Fructose-Bisphosphatase; Kinetics; Lysine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Proline; Swine | 2000 |
Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Isomerases; Amino Acid Motifs; Aminoacylation; Apoenzymes; Bacillus; Carbon Radioisotopes; Catalysis; Gramicidin; Histidine; Holoenzymes; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Peptide Chain Initiation, Translational; Phenylalanine; Protein Structure, Tertiary | 2001 |
Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hydroxybutyrates; Ions; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Mycobacterium tuberculosis; Oxygen; Peptide Synthases; Protein Binding; Recombinant Proteins; Temperature; Time Factors | 2001 |
Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Alanine; Amino Acid Substitution; Arginine; Bacillus subtilis; Binding Sites; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Genetic Complementation Test; Glutamic Acid; Kinetics; Light; Lysine; Molecular Weight; Mutagenesis, Site-Directed; Peptide Fragments; Protein Structure, Secondary; Scattering, Radiation; Tritium | 2002 |
Functional role of "N" (nucleotide) and "P" (phosphorylation) domain interactions in the sarcoplasmic reticulum (SERCA) ATPase.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Amino Acid Substitution; Animals; Arginine; Binding Sites; Calcium-Transporting ATPases; COS Cells; Cross-Linking Reagents; Endopeptidase K; Hydrolysis; Lysine; Phosphorylation; Photosensitizing Agents; Protein Structure, Tertiary; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Vanadates | 2002 |
Purinergic regulation of glucose and glutamine synthesis in isolated rabbit kidney-cortex tubules.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Ammonium Chloride; Animals; Aspartic Acid; Calcium Signaling; Cyclic AMP; Dose-Response Relationship, Drug; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glutamine; Glycerol; Hypoxanthine; In Vitro Techniques; Inosine; Kidney Tubules; Ligands; Male; Phosphorylation; Pyruvic Acid; Rabbits; Signal Transduction | 2002 |
Crucial role of conserved lysine 277 in the fidelity of tRNA aminoacylation by Escherichia coli valyl-tRNA synthetase.
Topics: Acylation; Adenosine Monophosphate; Alanine; Amino Acid Sequence; Binding Sites; Catalytic Domain; Conserved Sequence; Escherichia coli Proteins; Lysine; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; RNA Editing; RNA, Transfer, Thr; RNA, Transfer, Val; Sequence Alignment; Sequence Homology, Amino Acid; Threonine; Valine-tRNA Ligase | 2002 |
An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate. II. Reconstruction of the system from purified components.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Nucleosides; Nucleotides; Ribonucleases | 1959 |
STUDIES ON ADENOSINE TRIPHOSPHATE-ADENOSINE TRIPHOSPHATE TRANSPHOSPHORYLASES. V. CARBOXYL-TERMINAL SEQUENCES OF ADENOSINE TRIPHOSPHATE-CREATINE TRANSPHOSPHORYLASE AND OF ADENOSINE 5'-PHOSPHATE TRANSPHOSPHORYLASE (MYOKINASE).
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adenylate Kinase; Alanine; Carboxypeptidases; Chromatography; Creatine; Creatine Kinase; Glutamine; Leucine; Lysine; Phosphotransferases; Research; Valine | 1964 |
MTAP homozygous deletion: an Achilles heel of human cancers ready for clinical use?
Topics: Adenosine Monophosphate; Alanine; Antibiotics, Antineoplastic; Clinical Trials as Topic; Drug Resistance, Neoplasm; Gene Deletion; Homozygote; Humans; Neoplasms; Purine-Nucleoside Phosphorylase | 2005 |
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.
Topics: Adenosine Monophosphate; Alanine; Analysis of Variance; Animals; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Design; Fructose-Bisphosphatase; Gluconeogenesis; Humans; Liver; Male; Molecular Mimicry; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Rats, Zucker; Spectrophotometry; Thiazoles | 2005 |
Mutation of the adenylylated tyrosine of glutamine synthetase alters its catalytic properties.
Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Alanine; Catalysis; Cations, Divalent; Enzyme Activation; Escherichia coli Proteins; Esterification; Feedback, Physiological; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Glutamine; Hydrogen-Ion Concentration; Hydroxides; Magnesium; Manganese; Mutagenesis, Site-Directed; Phenylalanine; Serine; Tyrosine | 2005 |
Structure-guided mutational analysis of T4 RNA ligase 1.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Sequence; Binding Sites; Conserved Sequence; DNA Mutational Analysis; Glutamic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Protein Conformation; RNA Ligase (ATP); Structure-Activity Relationship; Tyrosine; Viral Proteins | 2006 |
Structural basis for catalysis by onconase.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Binding Sites; Catalysis; Crystallography, X-Ray; Disulfides; Glutamic Acid; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; K562 Cells; Kinetics; Lysine; Models, Biological; Models, Chemical; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Ribonucleases; Sequence Homology, Amino Acid; Substrate Specificity; X-Ray Diffraction | 2008 |
Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1).
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Amino Acid Sequence; Animals; Carnosine; Cell Line; Chickens; gamma-Aminobutyric Acid; Humans; Mass Spectrometry; Mice; Molecular Sequence Data; Peptide Synthases; Peptides; Sequence Homology, Amino Acid; Substrate Specificity | 2010 |
Using a fluorescent cytosine analogue tC(o) to probe the effect of the Y567 to Ala substitution on the preinsertion steps of dNMP incorporation by RB69 DNA polymerase.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Substitution; Bacteriophages; Base Pairing; Binding Sites; Crystallography, X-Ray; Cytosine; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA-Directed DNA Polymerase; Isomerism; Models, Molecular; Protein Conformation; Viral Proteins | 2012 |
Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Sequence; Aminoglycosides; Anti-Bacterial Agents; Aspartic Acid; Bacterial Proteins; Crystallography, X-Ray; Escherichia coli; Models, Molecular; Molecular Sequence Data; Multigene Family; Mutation; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Synthases; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Tryptophan | 2013 |
Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Motifs; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Mutagenesis; Nucleotidases; Phylogeny; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2014 |
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Sequence; Animals; Antiviral Agents; Cell Line, Tumor; Ebolavirus; Female; HeLa Cells; Hemorrhagic Fever, Ebola; Humans; Macaca mulatta; Male; Molecular Sequence Data; Organ Specificity; Prodrugs; Ribonucleotides | 2016 |
Late Ebola virus relapse causing meningoencephalitis: a case report.
Topics: Acute Disease; Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Cranial Nerve Diseases; Disease Outbreaks; Drugs, Investigational; Ebolavirus; Female; Genome, Viral; Hemorrhagic Fever, Ebola; Humans; Meningoencephalitis; Nurses; Radiculopathy; Recurrence; Ribonucleotides; RNA, Viral; Scotland; Sierra Leone; Viral Load | 2016 |
Multiple Quality Control Pathways Limit Non-protein Amino Acid Use by Yeast Cytoplasmic Phenylalanyl-tRNA Synthetase.
Topics: Acylation; Adenosine Monophosphate; Alanine; Mutation; Phenylalanine; Phenylalanine-tRNA Ligase; RNA, Fungal; RNA, Transfer, Phe; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2016 |
First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; Blood; Female; Hemorrhagic Fever, Ebola; Humans; Immunologic Factors; Infant, Newborn; Pregnancy; Ribonucleotides; Therapies, Investigational; Treatment Outcome; Young Adult | 2017 |
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
Topics: Adenosine Monophosphate; Alanine; Amides; Cell Line; Drug Discovery; Hemorrhagic Fever, Ebola; Humans; Microbial Sensitivity Tests; Phosphoric Acids; Prodrugs; Ribonucleotides; Structure-Activity Relationship; Virus Diseases | 2017 |
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.
Topics: A549 Cells; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; Ebolavirus; Gene Expression; HEK293 Cells; HeLa Cells; Hepatocytes; Humans; Marburgvirus; Microbial Sensitivity Tests; Nucleosides; Paramyxoviridae; Pneumovirinae; Prodrugs; Ribonucleotides; RNA-Dependent RNA Polymerase; Vero Cells; Viral Proteins | 2017 |
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Callithrix; Cell Line; Coronavirus; Epidemics; Epithelial Cells; Humans; Lung; Mice; Ribonucleotides; Virus Replication; Zoonoses | 2017 |
Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Kinetics; Molecular Dynamics Simulation; Mutation; Mycobacterium tuberculosis; Peptide Synthases; Protein Binding; Substrate Specificity | 2018 |
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus; Exoribonucleases; Mice; Mutation; Ribonucleotides; Severe acute respiratory syndrome-related coronavirus; Virus Replication | 2018 |
Experimental drugs poised for use in Ebola outbreak.
Topics: Adenosine Monophosphate; Alanine; Amides; Antibodies, Monoclonal; Congo; Disease Outbreaks; Drugs, Investigational; Ebola Vaccines; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Internationality; Pyrazines; Ribonucleotides | 2018 |
Public health round-up.
Topics: Adenosine Monophosphate; Alanine; Aminoisobutyric Acids; Anti-Bacterial Agents; Antibodies, Monoclonal; Benzimidazoles; Cyclopropanes; Democratic Republic of the Congo; Disease Outbreaks; Drug Resistance, Bacterial; Global Health; Hemorrhagic Fever, Ebola; Hepatitis C; Humans; Interinstitutional Relations; Lactams, Macrocyclic; Leucine; Malaria; Measles; Measles Vaccine; Poliomyelitis; Proline; Public Health Practice; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Ribonucleotides; Sulfonamides; Tuberculosis | 2019 |
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Antiviral Agents; DNA-Directed RNA Polymerases; Ebolavirus; Enzyme Inhibitors; Humans; Kinetics; Molecular Structure; Prodrugs; Respiratory Syncytial Virus, Human; Ribonucleotides; RNA-Dependent RNA Polymerase; RNA, Viral; Substrate Specificity; Viral Proteins | 2019 |
Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge.
Topics: Adenosine Monophosphate; Alanine; Animals; Brain; Chlorocebus aethiops; Female; Henipavirus Infections; Male; Meningoencephalitis; Neutralization Tests; Nipah Virus; Viremia; Virus Replication | 2019 |
Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Cell Line; Coronavirus; Coronavirus Infections; Humans; Middle East Respiratory Syndrome Coronavirus; Phylogeny; RNA-Dependent RNA Polymerase; Severe acute respiratory syndrome-related coronavirus; Swine; Virus Replication | 2019 |
Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target.
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Burkholderia pseudomallei; Enzyme Inhibitors; Molecular Docking Simulation; Peptide Synthases; Protein Binding; Small Molecule Libraries | 2019 |
New treatments for Ebola virus disease.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; Blood-Brain Barrier; Democratic Republic of the Congo; Ebolavirus; Epidemics; Hemorrhagic Fever, Ebola; Humans; Infusions, Intravenous; International Cooperation; Randomized Controlled Trials as Topic; Ribonucleotides | 2019 |
Non-gradient and genotype-dependent patterns of RSV gene expression.
Topics: Adenosine Monophosphate; Alanine; Animals; Cell Line; Female; Genotype; Half-Life; Humans; Male; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; RNA Stability; RNA, Messenger; RNA, Viral; Sigmodontinae; Transcription, Genetic; Virus Replication | 2020 |
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Carboxylesterase; Coronavirus Infections; Drug Combinations; Drug Development; Female; Humans; Interferon-beta; Lopinavir; Lung Injury; Male; Mice; Mice, Knockout; Middle East Respiratory Syndrome Coronavirus; Ritonavir; Viral Load; Virus Replication | 2020 |
Drug treatment options for the 2019-new coronavirus (2019-nCoV).
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Drug Discovery; Humans; Lopinavir; Neuraminidase; Nucleosides; Pneumonia, Viral; Ribonucleotides; Ritonavir; SARS-CoV-2 | 2020 |
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Topics: Adenosine Monophosphate; Alanine; Animals; Antimalarials; Antiviral Agents; Betacoronavirus; Biological Assay; Chlorocebus aethiops; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Discovery; Drug Evaluation, Preclinical; Humans; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus; Sincalide; Vero Cells | 2020 |
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Disease Models, Animal; Lung; Macaca mulatta; Male; Middle East Respiratory Syndrome Coronavirus; Pandemics; Pneumonia, Viral; Post-Exposure Prophylaxis; SARS-CoV-2; Viral Load; Virus Replication | 2020 |
More than 80 clinical trials launch to test coronavirus treatments.
Topics: Adenosine Monophosphate; Alanine; Animals; Anti-HIV Agents; Betacoronavirus; China; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Dioxanes; Disease Models, Animal; Drug Combinations; Humans; Immunization, Passive; Lopinavir; Medicine, Chinese Traditional; Monosaccharides; Pandemics; Pneumonia, Viral; Registries; Ritonavir; SARS-CoV-2; Severe Acute Respiratory Syndrome; Stem Cell Transplantation; Steroids; Time Factors; Treatment Outcome; World Health Organization | 2020 |
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus; Ebolavirus; Gene Expression; Middle East Respiratory Syndrome Coronavirus; Nucleic Acid Synthesis Inhibitors; RNA; RNA-Dependent RNA Polymerase; Sf9 Cells; Viral Nonstructural Proteins; Virus Replication | 2020 |
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.
Topics: Adenosine Monophosphate; Alanine; Alphacoronavirus; Amino Acid Sequence; Antiviral Agents; Betacoronavirus; Catalytic Domain; Computational Biology; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Molecular Docking Simulation; Pneumonia, Viral; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Ribavirin; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sequence Alignment; Sequence Homology, Amino Acid; Sofosbuvir; Thermodynamics; Uridine Triphosphate; Viral Proteins | 2020 |
Therapeutic options for the 2019 novel coronavirus (2019-nCoV).
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Hepatitis B; Hepatitis C; HIV Infections; Humans; Influenza, Human; Interferon-alpha; Middle East Respiratory Syndrome Coronavirus; Nucleosides; Pneumonia, Viral; Polyethylene Glycols; Protease Inhibitors; Recombinant Proteins; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus | 2020 |
Breastfeeding and Respiratory Antivirals: Coronavirus and Influenza.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Breast Feeding; Coronavirus Infections; COVID-19; Female; Humans; Infant; Infant, Newborn; Influenza, Human; Milk, Human; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Coronavirus; Coronavirus Infections; COVID-19; Hydroxychloroquine; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Arguments in favour of remdesivir for treating SARS-CoV-2 infections.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; DNA-Directed RNA Polymerases; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Discovering drugs to treat coronavirus disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Chloroquine; Clinical Studies as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Discovery; Humans; Indoles; Pandemics; Pneumonia, Viral; Pyrazines; Ribonucleotides; SARS-CoV-2; Virus Replication | 2020 |
Advance of promising targets and agents against COVID-19 in China.
Topics: Adenine; Adenosine Monophosphate; Alanine; Amides; Antimalarials; Antiviral Agents; Betacoronavirus; China; Chloroquine; Clinical Trials as Topic; Cobicistat; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cysteine Endopeptidases; Dibenzothiepins; Drug Combinations; Drug Discovery; Drug Therapy, Combination; Emtricitabine; Humans; Hydroxychloroquine; Indoles; Lopinavir; Medicine, Chinese Traditional; Morpholines; Oseltamivir; Oxazines; Pandemics; Pneumonia, Viral; Pyrazines; Pyridines; Pyridones; Ritonavir; RNA-Dependent RNA Polymerase; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Tenofovir; Thiepins; Triazines; Viral Nonstructural Proteins | 2020 |
Are there any Therapeutic Options Currently Available for Wuhan Coronavirus?
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Betacoronavirus; Chloroquine; Communicable Disease Control; Coronavirus Infections; COVID-19; Drug Discovery; Drug Repositioning; Humans; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; SARS-CoV-2; Virus Internalization | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate Use Trials; Cord Blood Stem Cell Transplantation; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Critical Illness; Cytokines; Humans; Hydroxychloroquine; Mesenchymal Stem Cell Transplantation; Pandemics; Pneumonia, Viral; SARS-CoV-2; Umbilical Cord; United States; Viral Vaccines | 2020 |
Race to find COVID-19 treatments accelerates.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Biomedical Research; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Hydroxychloroquine; Lopinavir; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2; World Health Organization | 2020 |
Remdesivir attenuates high fat diet (HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING.
Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Animals; Antiviral Agents; Diet, High-Fat; Dyslipidemias; Hepatocytes; Inflammation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Palmitates | 2020 |
A Community-transmitted Case of Severe Acute Respiratory Distress Syndrome (SARS) Due to SARS-CoV-2 in the United States.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Community-Acquired Infections; COVID-19; COVID-19 Drug Treatment; Female; Humans; Middle Aged; Respiratory Distress Syndrome; Risk Factors; Shock, Septic; Thorax; Tomography, X-Ray Computed; Treatment Outcome; United States | 2020 |
To consider or not antimalarials as a prophylactic intervention in the SARS-CoV-2 (Covid-19) pandemic.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Betacoronavirus; Chloroquine; Coronavirus; Coronavirus Infections; COVID-19; Pandemics; Pneumonia, Viral; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus | 2020 |
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antimetabolites; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Emetine; Epithelial Cells; Homoharringtonine; Humans; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ribavirin; SARS-CoV-2; Vero Cells; Virus Replication | 2020 |
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibiotic Prophylaxis; Antiviral Agents; Betacoronavirus; Cell Line; Coronavirus Infections; COVID-19; Cytidine; Disease Models, Animal; Drug Resistance, Viral; Humans; Hydroxylamines; Lung; Mice; Mice, Inbred C57BL; Middle East Respiratory Syndrome Coronavirus; Models, Molecular; Mutation; Pandemics; Pneumonia, Viral; Primary Cell Culture; Random Allocation; Respiratory System; Ribonucleosides; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Virus Replication | 2020 |
Compassionate Use of Remdesivir for Patients with Severe Covid-19.
Topics: Adenosine Monophosphate; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Alanine; Antiviral Agents; Betacoronavirus; Canada; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Europe; Female; Humans; Japan; Male; Middle Aged; Pandemics; Pneumonia, Viral; Respiration, Artificial; SARS-CoV-2; United States; Young Adult | 2020 |
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Catalytic Domain; Coronavirus RNA-Dependent RNA Polymerase; Cryoelectron Microscopy; Drug Design; Models, Molecular; Multiprotein Complexes; Protein Conformation, beta-Strand; Protein Domains; RNA-Dependent RNA Polymerase; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |
Halting coronavirus polymerase.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus; Coronavirus Infections; Exonucleases; Humans; Pandemics; RNA-Dependent RNA Polymerase; Virus Replication | 2020 |
Delayed Initiation of Remdesivir in a COVID-19-Positive Patient.
Topics: Adenosine Monophosphate; Adult; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Hydroxychloroquine; Male; Pandemics; Pneumonia, Viral; SARS-CoV-2; Time Factors; Time-to-Treatment | 2020 |
Coronavirus Disease (COVID-19) Pandemic: A Race Against Time.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Vaccines; Hand Hygiene; Humans; International Cooperation; Masks; Pandemics; Patient Education as Topic; Pneumonia, Viral; Quarantine; SARS-CoV-2; Viral Vaccines | 2020 |
Early impact of COVID-19 on transplant center practices and policies in the United States.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Critical Illness; Evidence-Based Medicine; Health Policy; Humans; Hydroxychloroquine; Incidence; Kidney Failure, Chronic; Kidney Transplantation; Liver Transplantation; Living Donors; Organ Transplantation; Pandemics; Pneumonia, Viral; Resource Allocation; SARS-CoV-2; Surveys and Questionnaires; Tissue Donors; Transplant Recipients; United States | 2020 |
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites.
Topics: Adenosine Monophosphate; Alanine; Antimetabolites; Antiviral Agents; Betacoronavirus; Catalytic Domain; Coronavirus Infections; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Drug Resistance, Viral; Exoribonucleases; Humans; Models, Molecular; Mutation; Pandemics; Pneumonia, Viral; Protein Conformation; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Structure-Activity Relationship; Viral Nonstructural Proteins | 2020 |
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Models, Molecular; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sf9 Cells; Spodoptera; Virus Replication | 2020 |
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; China; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Darunavir; Drug Combinations; Humans; Hydroxychloroquine; Indoles; Lopinavir; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; SARS-CoV-2 | 2020 |
COVID-2019: update on epidemiology, disease spread and management.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Basic Reproduction Number; Betacoronavirus; Clinical Laboratory Techniques; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Humans; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Quarantine; Receptors, Virus; SARS-CoV-2 | 2020 |
The race against COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Viral; Antiviral Agents; Betacoronavirus; Clinical Laboratory Techniques; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Humans; Hydroxychloroquine; Nucleic Acid Amplification Techniques; Pandemics; Pneumonia, Viral; SARS-CoV-2; Viral Vaccines | 2020 |
Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Amino Acid Substitution; Catalytic Domain; Lysine; Manganese; Models, Molecular; Naegleria; RNA Ligase (ATP) | 2020 |
COVID-19 in a high-risk dual heart and kidney transplant recipient.
Topics: Adenosine Monophosphate; Adult; Alanine; Betacoronavirus; Cardiomyopathy, Dilated; Coronavirus Infections; COVID-19; Heart Transplantation; Humans; Hydroxychloroquine; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Male; Pandemics; Pneumonia, Viral; Radiography, Thoracic; Randomized Controlled Trials as Topic; Risk Factors; SARS-CoV-2; Treatment Outcome | 2020 |
Remdesivir in covid-19.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; Ribonucleotides; SARS-CoV-2 | 2020 |
Some drugs for COVID-19.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Azithromycin; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Drug Repositioning; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Neuraminidase; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2 | 2020 |
Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Aquatic Organisms; Biological Products; Chloroquine; Coronavirus Infections; COVID-19; Drug Compounding; Humans; Hydroxychloroquine; Models, Molecular; Pandemics; Pneumonia, Viral; Volatilization | 2020 |
COVID-19 in solid organ transplant recipients: Initial report from the US epicenter.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azithromycin; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Critical Care; Female; Hospitalization; Humans; Hydroxychloroquine; Immunosuppression Therapy; Immunosuppressive Agents; Intensive Care Units; Intubation; Male; Middle Aged; New York City; Organ Transplantation; Pandemics; Pneumonia, Viral; Respiration, Artificial; SARS-CoV-2; Steroids; Transplant Recipients; Treatment Outcome; United States | 2020 |
Chloroquine hype is derailing the search for coronavirus treatments.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Coronavirus; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
The clinical manifestations and management of COVID-19-related liver injury.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Liver; Liver Diseases; Liver Function Tests; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Coronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Catalytic Domain; Coronavirus RNA-Dependent RNA Polymerase; Cryoelectron Microscopy; Enzyme Inhibitors; Models, Molecular; Multiprotein Complexes; Protein Conformation; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Viral Nonstructural Proteins; Virus Replication | 2020 |
Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway.
Topics: Adenosine Monophosphate; Alanine; Animals; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Cell Proliferation; Cells, Cultured; Chlorocebus aethiops; Complex Mixtures; Coronavirus Infections; COVID-19; Humans; Inflammation Mediators; NF-kappa B; Pandemics; Pneumonia, Viral; SARS-CoV-2; Signal Transduction; Virion | 2020 |
Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Betacoronavirus; Chromatography, High Pressure Liquid; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Hemorrhagic Fever, Ebola; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; Sensitivity and Specificity; Tandem Mass Spectrometry | 2020 |
Five reasons why data on compassionate use of remdesivir deserved publication (and are worth reading).
Topics: Adenosine Monophosphate; Alanine; Compassionate Use Trials; Humans; Reading | 2020 |
The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications.
Topics: ADAM17 Protein; Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Benzylisoquinolines; Betacoronavirus; Biological Transport; Cathepsin L; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Endocytosis; Endosomes; Glycopeptides; Humans; Hydroxychloroquine; Intracellular Signaling Peptides and Proteins; Lysosomes; Membrane Lipids; Membrane Microdomains; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Oxysterols; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Receptors, Virus; SARS-CoV-2; Serine Endopeptidases; Triazoles; Virus Internalization | 2020 |
Repurposing of chloroquine and some clinically approved antiviral drugs as effective therapeutics to prevent cellular entry and replication of coronavirus.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Azithromycin; Chloroquine; Drug Repositioning; Humans; Lopinavir; Molecular Docking Simulation; Severe acute respiratory syndrome-related coronavirus; Virus Internalization; Virus Replication | 2021 |
Audio Interview: Studying Potential Covid-19 Therapies.
Topics: Adenosine Monophosphate; Alanine; Anti-Infective Agents; Azithromycin; Betacoronavirus; Controlled Clinical Trials as Topic; Coronavirus Infections; COVID-19; Drug Therapy, Combination; Humans; Hydroxychloroquine; Observational Studies as Topic; Pandemics; Pneumonia, Viral; Research Design; SARS-CoV-2 | 2020 |
When the Others Become Us: A Chemist's Perspective of the COVID-19 Outbreak in Italy.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Betacoronavirus; Biomedical Research; Chemistry; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Italy; Laboratories; Pandemics; Phylogeny; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Novel coronavirus 2019 (COVID-19): A case report and review of treatments.
Topics: Adenosine Monophosphate; Aged; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Fatal Outcome; Female; Humans; Hydroxychloroquine; Pandemics; Pneumonia, Viral; Respiratory Distress Syndrome; SARS-CoV-2 | 2020 |
[Chloroquine as a possible treatment for COVID-19].
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Humans; Lopinavir; Off-Label Use; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2; Treatment Outcome | 2020 |
Remdesivir in the treatment of coronavirus disease 2019 (COVID-19): a simplified summary.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pandemics | 2021 |
[The "Historic Study" SOLIDARITY-Research's Answer to the Sars-CoV-2 Pandemic].
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Bioethical Issues; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Drug Combinations; Editorial Policies; Humans; Hydroxychloroquine; International Cooperation; Lopinavir; Pandemics; Pneumonia, Viral; Research Design; Ritonavir; SARS-CoV-2; World Health Organization | 2020 |
In Vitro Data of Current Therapies for SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; China; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Emetine; Homoharringtonine; Humans; Hydroxychloroquine; Ivermectin; Lopinavir; Nitro Compounds; Pandemics; Pneumonia, Viral; SARS-CoV-2; Teicoplanin; Thiazoles | 2020 |
What Do We Know About Remdesivir Drug Interactions?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Compassionate Use Trials; COVID-19; COVID-19 Drug Treatment; Drug Interactions; Drug Therapy, Combination; Excipients; Humans; Pandemics; Review Literature as Topic | 2020 |
Case 17-2020: A 68-Year-Old Man with Covid-19 and Acute Kidney Injury.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Aged; Alanine; Amides; Anti-Inflammatory Agents; Anticoagulants; Antiviral Agents; Betacoronavirus; Continuous Renal Replacement Therapy; Coronavirus Infections; COVID-19; Creatinine; Humans; Hypertension; Lung; Male; Obesity; Pandemics; Pneumonia, Viral; Pyrazines; Radiography, Thoracic; SARS-CoV-2 | 2020 |
Coronavirus drugs trials must get bigger and more collaborative.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Compassionate Use Trials; Coronavirus; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Characteristics and Outcomes of Coronavirus Disease Patients under Nonsurge Conditions, Northern California, USA, March-April 2020.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Asthma; Azithromycin; Betacoronavirus; California; Clinical Laboratory Techniques; Comorbidity; Coronavirus Infections; COVID-19; COVID-19 Testing; Diabetes Mellitus; Female; Humans; Hyperlipidemias; Hypertension; Intensive Care Units; Length of Stay; Male; Pandemics; Pneumonia, Viral; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Severity of Illness Index; Survival Analysis; Tomography, X-Ray Computed | 2020 |
Emergency Use Authorization of Remdesivir: The Need for a Transparent Distribution Process.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Approval; Emergencies; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; United States | 2020 |
Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 at a Tertiary Care Medical Center in New York City.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Asthma; Betacoronavirus; Blood Urea Nitrogen; C-Reactive Protein; Child; Child, Preschool; Coronavirus Infections; COVID-19; Creatinine; Critical Illness; Dyspnea; Female; Hospitalization; Hospitals, Pediatric; Humans; Infant; Infant, Newborn; Intensive Care Units, Pediatric; Male; Natriuretic Peptide, Brain; New York City; Pandemics; Pediatric Obesity; Platelet Count; Pneumonia, Viral; Procalcitonin; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Sepsis; Shock, Septic; Tertiary Care Centers; Young Adult | 2020 |
Dozens of coronavirus drugs are in development - what happens next?
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Coronavirus Infections; COVID-19; Drug Development; Drug Industry; Humans; Hydroxychloroquine; Oseltamivir; Pandemics; Pneumonia, Viral | 2020 |
Compassionate Use of Remdesivir in Covid-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Compassionate Use of Remdesivir in Covid-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Compassionate Use of Remdesivir in Covid-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Compassionate Use of Remdesivir in Covid-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Compassionate Use of Remdesivir in Covid-19. Reply.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
The sprint to solve coronavirus protein structures - and disarm them with drugs.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Azoles; Betacoronavirus; China; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Papain-Like Proteases; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Vaccines; Cryoelectron Microscopy; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Drug Design; Drug Evaluation, Preclinical; Germany; High-Throughput Screening Assays; Humans; Isoindoles; Mice; National Institutes of Health (U.S.); Organoselenium Compounds; Peptidyl-Dipeptidase A; Protease Inhibitors; RNA-Dependent RNA Polymerase; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Synchrotrons; Time Factors; United Kingdom; United States; Viral Nonstructural Proteins; Viral Proteins; Viral Vaccines | 2020 |
Early experience with remdesivir in SARS-CoV-2 pneumonia.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chemical and Drug Induced Liver Injury; Convalescence; Coronavirus Infections; COVID-19; Critical Illness; Darunavir; Drug Administration Schedule; Drug Combinations; Fatal Outcome; Humans; Hydroxychloroquine; Lopinavir; Multiple Organ Failure; Pandemics; Pneumonia, Viral; Ritonavir; RNA, Viral; SARS-CoV-2; Torsades de Pointes | 2020 |
Protect Pregnant and Lactating Women with COVID-19 Through Research, Not from Research.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Breast Feeding; Coronavirus Infections; COVID-19; Drug Approval; Female; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infectious Disease Transmission, Vertical; Lactation; Milk, Human; Pandemics; Pneumonia, Viral; Pregnancy; Risk Assessment; SARS-CoV-2 | 2020 |
Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Interleukin 1 Receptor Antagonist Protein; Male; Middle Aged; Pandemics; Pneumonia, Viral; Receptors, Interleukin-1; Respiratory Insufficiency; SARS-CoV-2 | 2020 |
[From empiricism to scientific evidence in antiviral treatment in severe cases of coronavirus infection in times of epidemic].
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chloroquine; Clinical Decision-Making; Clinical Trials as Topic; Coronavirus Infections; Cost-Benefit Analysis; COVID-19; Drug Combinations; Empiricism; Humans; Hydroxychloroquine; Information Dissemination; Lopinavir; Pandemics; Pneumonia, Viral; Reproducibility of Results; Ritonavir; SARS-CoV-2; Viral Load | 2020 |
Remdesivir for COVID-19: challenges of underpowered studies.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Double-Blind Method; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2020 |
Does lopinavir really inhibit SARS-CoV-2?
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Emetine; Homoharringtonine; Humans; Lopinavir; Pandemics; Pneumonia, Viral; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus | 2020 |
5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Deoxyribonucleosides; Deoxyribose; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Inflammation; Models, Theoretical; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Structure of replicating SARS-CoV-2 polymerase.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus RNA-Dependent RNA Polymerase; Cryoelectron Microscopy; Models, Molecular; Protein Conformation; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |
Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; RNA, Viral; SARS-CoV-2 | 2020 |
Synergistic effect of vitamin D and remdesivir can fight COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Vitamin D | 2021 |
Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit.
Topics: Adenosine Monophosphate; Administration, Inhalation; Administration, Intravenous; Alanine; Animals; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus 3C Proteases; Cysteine; Cysteine Endopeptidases; Molecular Docking Simulation; Ritonavir; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |
Remdesivir - An Important First Step.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Audio Interview: New Data on Remdesivir in Covid-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Administration Schedule; Drug Evaluation; Humans; Hydroxychloroquine; Infusions, Intravenous; Pandemics; Placebos; Pneumonia, Viral; Randomized Controlled Trials as Topic; SARS-CoV-2; Time Factors; Treatment Outcome; Viral Load | 2020 |
Remdesivir and Potential Interactions With Psychotropic Medications: A COVID-19 Perspective.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Interactions; Humans; Pandemics; Pneumonia, Viral; Psychotropic Drugs; SARS-CoV-2 | 2020 |
Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus.
Topics: Adenosine Monophosphate; Alanine; Animals; Antimetabolites; Antiviral Agents; Disease Models, Animal; Female; Kaplan-Meier Estimate; Macaca fascicularis; Male; Marburg Virus Disease; Marburgvirus; Monkey Diseases; RNA, Viral | 2020 |
Direct endothelial damage and vasculitis due to SARS-CoV-2 in small bowel submucosa of COVID-19 patient with diarrhea.
Topics: Adenosine Monophosphate; Adult; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Diarrhea; Female; Humans; Intestinal Mucosa; Intestine, Small; SARS-CoV-2; Vasculitis | 2021 |
Remdesivir and tocilizumab: Mix or match.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; COVID-19 Drug Treatment; Cytokine Release Syndrome; Humans; Receptors, Interleukin-6; SARS-CoV-2 | 2021 |
An update on novel COVID-19 pandemic: a battle between humans and virus.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; Respiratory Distress Syndrome; RNA, Viral; SARS-CoV-2; Survival Analysis | 2020 |
Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Adolescent; Adult; Alanine; Antiviral Agents; Child; Child, Preschool; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Administration Schedule; Drug Dosage Calculations; Female; Humans; Hydroxychloroquine; Infant; Infant, Newborn; Male; Models, Biological; Pandemics; Patient Simulation; Pneumonia, Viral; Therapies, Investigational; Young Adult | 2020 |
Efficacy of remdesivir in patients with COVID-19: a protocol for systematic review and meta-analysis of randomised controlled trials.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Infection Control; Meta-Analysis as Topic; Pandemics; Pneumonia, Viral; Research Design; SARS-CoV-2; Systematic Reviews as Topic; Treatment Outcome | 2020 |
[Remdesivir til behandling af COVID-19-pneumoni].
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Betacoronavirus; Bronchoalveolar Lavage Fluid; Coronavirus Infections; COVID-19; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Drug Resistance, Viral; Female; Lung; Macaca mulatta; Male; Pandemics; Pneumonia, Viral; SARS-CoV-2; Secondary Prevention; Time Factors; Viral Load; Virus Replication; Virus Shedding | 2020 |
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Humans; Negative Results; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
COVID-19 in lung transplant recipients.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Cough; COVID-19; Cross Infection; Cystic Fibrosis; Dyspnea; Female; Fever; Gastrointestinal Diseases; Glucocorticoids; Graft Rejection; Humans; Idiopathic Pulmonary Fibrosis; Immunoglobulins, Intravenous; Immunologic Factors; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Lung; Lung Transplantation; Male; Methylprednisolone; Middle Aged; Pancreatitis, Acute Necrotizing; Pulmonary Disease, Chronic Obstructive; Pulse Therapy, Drug; SARS-CoV-2; Sepsis; Severity of Illness Index; Tomography, X-Ray Computed | 2020 |
Structural Basis of the Potential Binding Mechanism of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Amino Acid Sequence; Antiviral Agents; Betacoronavirus; Binding Sites; Coronavirus RNA-Dependent RNA Polymerase; Enzyme Inhibitors; Hydrogen Bonding; Molecular Dynamics Simulation; Protein Binding; RNA-Dependent RNA Polymerase; SARS-CoV-2; Thermodynamics; Viral Nonstructural Proteins | 2020 |
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Catalytic Domain; Coronavirus RNA-Dependent RNA Polymerase; Cryoelectron Microscopy; Models, Chemical; Models, Molecular; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Transcription, Genetic; Viral Nonstructural Proteins; Virus Replication | 2020 |
Flight of the COVID-19 patient: experience with a Wuhan evacuee: a case report.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Blood Cell Count; California; China; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Testing; Disease Transmission, Infectious; Female; Humans; Liver Function Tests; Middle Aged; Pandemics; Pneumonia, Viral; Quarantine; Radiography, Thoracic; SARS-CoV-2; Treatment Outcome | 2020 |
The rationale for Low-Molecular Weight Heparin (LMWH) use in SARS-CoV-2 infection
Topics: Adenosine Monophosphate; Alanine; Anticoagulants; Antiviral Agents; Biomarkers; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Critical Care; Disease Management; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Embolism; Endothelium, Vascular; Heparin, Low-Molecular-Weight; Humans; Hydroxychloroquine; Interferon beta-1b; Lopinavir; Macrophage Activation; Pandemics; Pneumonia, Viral; Pulmonary Fibrosis; Randomized Controlled Trials as Topic; Ritonavir; Thromboembolism; Thrombophilia; Thrombosis | 2020 |
Uncertainty about the Efficacy of Remdesivir on COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Repositioning; Humans; Pandemics; Pneumonia, Viral; RNA-Dependent RNA Polymerase; SARS-CoV-2; Uncertainty; Virus Replication | 2020 |
Coronavirus breakthrough: dexamethasone is first drug shown to save lives.
Topics: Adenosine Monophosphate; Alanine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Critical Illness; Dexamethasone; Humans; Pandemics; Pneumonia, Viral; Preprints as Topic; Randomized Controlled Trials as Topic; Respiration, Artificial; Risk Assessment; Survival Rate | 2020 |
A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application.
Topics: Adenosine Monophosphate; Aerosols; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Humans; Inflammation; Lung; Models, Theoretical; Phenotype; Povidone-Iodine; SARS-CoV-2 | 2020 |
A Case of Breakthrough COVID-19 during Hydroxychloroquine Maintenance.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Azithromycin; Betacoronavirus; Coronavirus Infections; COVID-19; Female; Humans; Hydroxychloroquine; Middle Aged; Pandemics; Pneumonia, Viral; Primary Prevention; SARS-CoV-2 | 2020 |
[Remdesivir for patients with COVID-19].
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chromatography, Liquid; Coronavirus Infections; COVID-19; Drug Monitoring; Drug Stability; Female; Furans; Humans; Limit of Detection; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pyrroles; Reproducibility of Results; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2020 |
A Proposed Lottery System to Allocate Scarce COVID-19 Medications: Promoting Fairness and Generating Knowledge.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Approval; Health Care Rationing; Humans; Pandemics; Pneumonia, Viral; Resource Allocation; SARS-CoV-2; State Government | 2020 |
Missed Opportunities on Emergency Remdesivir Use.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Clinical Trials, Phase III as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Costs; Drugs, Investigational; Hemorrhagic Fever, Ebola; Humans; Length of Stay; National Institute of Allergy and Infectious Diseases (U.S.); Pandemics; Pneumonia, Viral; Registries; SARS-CoV-2; Treatment Outcome; United States | 2020 |
Validity of the UK early access to medicines scheme criteria for Remdesivir use in patients with COVID-19 disease.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Health Services Accessibility; Humans; London; Pandemics; Pneumonia, Viral; Retrospective Studies; SARS-CoV-2; State Medicine; United Kingdom | 2020 |
Statistical Issues and Lessons Learned From COVID-19 Clinical Trials With Lopinavir-Ritonavir and Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Coronavirus Infections; COVID-19 Drug Treatment; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Lopinavir; Randomized Controlled Trials as Topic; Research Design; Ritonavir; Treatment Outcome | 2020 |
Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; Chemical and Drug Induced Liver Injury; COVID-19 Drug Treatment; Humans; Male; SARS-CoV-2 | 2021 |
Optimizing Medication Management During the COVID-19 Pandemic: It Takes a Village.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Therapy; Humans; Hydroxychloroquine; Nurse-Patient Relations; Nursing Homes; Pandemics; Pneumonia, Viral; Prodrugs; SARS-CoV-2 | 2020 |
Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Critical Illness; Female; Humans; Male; Pandemics; Pneumonia, Viral; Recovery of Function; SARS-CoV-2 | 2020 |
Phylogenetic Analysis and Structural Perspectives of RNA-Dependent RNA-Polymerase Inhibition from SARs-CoV-2 with Natural Products.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Biological Products; Catalytic Domain; Computer Simulation; Coronavirus Infections; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Databases, Pharmaceutical; Drug Evaluation, Preclinical; Genome, Viral; Host Microbial Interactions; Humans; Ligands; Molecular Docking Simulation; Pandemics; Phylogeny; Pneumonia, Viral; RNA-Dependent RNA Polymerase; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |
Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Adult; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; C-Reactive Protein; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Female; Humans; Interleukin-6; Lung; Oximetry; Pandemics; Pneumonia, Viral; Pregnancy; Pregnancy Complications, Infectious; Radiography, Thoracic; SARS-CoV-2; Treatment Outcome | 2020 |
Case report study of the first five COVID-19 patients treated with remdesivir in France.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Female; France; Hospitalization; Humans; Male; Pandemics; Pneumonia, Viral; SARS-CoV-2; Viral Load; Withholding Treatment | 2020 |
A proposed strategy for management of immunosuppression in heart transplant patients with COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Algorithms; Antiviral Agents; Clinical Decision-Making; COVID-19; COVID-19 Testing; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Graft Rejection; Heart Transplantation; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Middle Aged; Postoperative Complications; Prospective Studies; Quality Improvement; SARS-CoV-2; Severity of Illness Index; Treatment Outcome | 2020 |
Idiopathic nonhistaminergic acquired angioedema in a patient with coronavirus disease 2019.
Topics: Adenosine Monophosphate; Adult; Alanine; Ampicillin; Angioedema; Betacoronavirus; Coronavirus Infections; COVID-19; Diabetes Mellitus, Type 2; Female; Humans; Hydroxychloroquine; Hyperlipidemias; Intubation, Intratracheal; Obesity; Pandemics; Pneumonia, Viral; Respiration, Artificial; Respiratory Insufficiency; SARS-CoV-2; Treatment Outcome | 2020 |
Leaks of Clinical Trial Data and Research Integrity.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Drug Industry; Ethics, Research; Humans; SARS-CoV-2; Security Measures | 2020 |
The Role of Remdesivir in South Africa: Preventing COVID-19 Deaths Through Increasing Intensive Care Unit Capacity.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Intensive Care Units; SARS-CoV-2; South Africa | 2021 |
Commentary: "Emergency Use Authorization for Remdesivir: A Pediatric Perspective".
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Emergency Treatment; Humans; Pediatrics; United States; United States Food and Drug Administration | 2020 |
Does remdesivir have any neuropsychiatric adverse effects?
Topics: Adenosine Monophosphate; Alanine; Humans | 2021 |
Remdesivir for the Treatment of Covid-19 - Preliminary Report.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir for the Treatment of Covid-19 - Preliminary Report.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir for the Treatment of Covid-19 - Preliminary Report.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir for the Treatment of Covid-19 - Preliminary Report.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir for the Treatment of Covid-19 - Preliminary Report. Reply.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir during induction chemotherapy for newly diagnosed paediatric acute lymphoblastic leukaemia with concomitant SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Child, Preschool; Coronavirus Infections; COVID-19; Humans; Induction Chemotherapy; Male; Pandemics; Pneumonia, Viral; Precursor Cell Lymphoblastic Leukemia-Lymphoma; SARS-CoV-2 | 2020 |
COVID-19 Therapeutics: Making Sense of It All.
Topics: Adenosine Monophosphate; Adult; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Berberine; Betacoronavirus; Chlorocebus aethiops; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cyclosporine; Drug Antagonism; Drug Combinations; Drug Repositioning; Drug Synergism; Humans; Indoles; Lopinavir; Pandemics; Pneumonia, Viral; SARS-CoV-2; Vero Cells | 2020 |
Remdesivir improved time to recovery in adults hospitalized with COVID-19 and lower respiratory tract involvement.
Topics: Adenosine Monophosphate; Adolescent; Adult; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2020 |
Using "old" medications to fight new COVID-19: Re-purposing with a purpose.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Dexamethasone; Diabetes Mellitus; Drug Repositioning; Host-Pathogen Interactions; Humans; Hydroxychloroquine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Obesity; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Potential Repurposed Therapeutics and New Vaccines against COVID-19 and Their Clinical Status.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiviral Agents; Chloroquine; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cyclopropanes; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Mice, Transgenic; Proline; Pyrazines; SARS-CoV-2; Small Molecule Libraries; Sulfonamides; Vaccines, Synthetic | 2020 |
Utilization of COVID-19 Treatments and Clinical Outcomes among Patients with Cancer: A COVID-19 and Cancer Consortium (CCC19) Cohort Study.
Topics: Adenosine Monophosphate; Age Factors; Aged; Alanine; Betacoronavirus; Clinical Decision-Making; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Drug Utilization; Follow-Up Studies; Glucocorticoids; Healthcare Disparities; Hospital Mortality; Humans; Hydroxychloroquine; Male; Middle Aged; Neoplasms; Pandemics; Pneumonia, Viral; Risk Factors; SARS-CoV-2; Severity of Illness Index; Sex Factors; Treatment Outcome; United States | 2020 |
Persistent COVID-19 in an Immunocompromised Patient Temporarily Responsive to Two Courses of Remdesivir Therapy.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Fever; Humans; Immunocompromised Host; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pandemics; Pneumonia, Viral; SARS-CoV-2; Severe Acute Respiratory Syndrome; Time Factors; Treatment Outcome | 2020 |
Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Motifs; Antiviral Agents; Betacoronavirus; Binding Sites; Databases, Protein; Hydrogen Bonding; Molecular Docking Simulation; Nucleic Acid Conformation; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Quantum Theory; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Thermodynamics; Viral Proteins | 2020 |
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Topics: Adenosine Monophosphate; Alanine; Alveolar Epithelial Cells; Antiviral Agents; Betacoronavirus; Cell Line; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Repositioning; Drug Synergism; Gene Expression Regulation; Humans; Hydrazones; Induced Pluripotent Stem Cells; Models, Biological; Morpholines; Pandemics; Pneumonia, Viral; Pyrimidines; Reproducibility of Results; SARS-CoV-2; Small Molecule Libraries; Triazines; Virus Internalization; Virus Replication | 2020 |
Interactions Between Remdesivir, Ribavirin, Favipiravir, Galidesivir, Hydroxychloroquine and Chloroquine with Fragment Molecular of the COVID-19 Main Protease with Inhibitor N3 Complex (PDB ID:6LU7) Using Molecular Docking.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Binding Sites; Chloroquine; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cysteine Endopeptidases; Drug Interactions; Humans; Hydrogen Bonding; Hydroxychloroquine; Ligands; Molecular Docking Simulation; Nanotechnology; Pandemics; Pneumonia, Viral; Protease Inhibitors; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Static Electricity; Viral Nonstructural Proteins | 2020 |
Ethical Allocation of Remdesivir.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Resource Allocation | 2020 |
Hepatic Disorders With the Use of Remdesivir for Coronavirus 2019.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chemical and Drug Induced Liver Injury; Coronavirus Infections; COVID-19; Europe; Female; Humans; Incidence; Male; Middle Aged; Pandemics; Pneumonia, Viral; SARS-CoV-2; United States | 2020 |
Liver injury in remdesivir-treated COVID-19 patients.
Topics: Adenosine Monophosphate; Administration, Intravenous; Adult; Aged; Alanine; Antiviral Agents; Betacoronavirus; Chemical and Drug Induced Liver Injury; Compassionate Use Trials; Coronavirus Infections; COVID-19; Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Italy; Liver Function Tests; Male; Middle Aged; Pandemics; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
[COVID-19: a cardiological point-of-view].
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Arteritis; Betacoronavirus; Cardiovascular Diseases; Coronavirus Infections; COVID-19; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; Venous Thrombosis | 2020 |
Remdesivir for severe covid-19: a clinical practice guideline.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Guideline Adherence; Humans; Length of Stay; Network Meta-Analysis; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; Respiration, Artificial; SARS-CoV-2; Severity of Illness Index; Time Factors; Treatment Outcome | 2020 |
The Multidimensional Challenge of Treating Coronavirus Disease 2019 (COVID-19): Remdesivir Is a Foot in the Door.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Probing antiviral drugs against SARS-CoV-2 through virus-drug association prediction based on the KATZ method.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Drug Evaluation, Preclinical; Host-Pathogen Interactions; Humans; Molecular Docking Simulation; Oseltamivir; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Zanamivir | 2020 |
Communicating Science in the Time of a Pandemic.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Communication; Coronavirus Infections; COVID-19; Dexamethasone; Glucocorticoids; Humans; Hydroxychloroquine; Journalism, Medical; Pandemics; Peer Review, Research; Pneumonia, Viral; SARS-CoV-2; Science | 2020 |
Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice.
Topics: Adaptation, Physiological; Adenosine Monophosphate; Administration, Intranasal; Alanine; Animals; Betacoronavirus; Chlorocebus aethiops; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Female; Host Specificity; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation, Missense; Nasal Mucosa; Pandemics; Pneumonia, Viral; RNA, Viral; SARS-CoV-2; Turbinates; Vero Cells; Viral Load; Virus Replication | 2020 |
BET 1: The role of remdesivir in COVID-19 infection.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Evidence-Based Practice; Female; Humans; Male; Pandemics; Pneumonia, Viral; SARS-CoV-2; Treatment Outcome | 2020 |
The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid.
Topics: Adenosine Monophosphate; Alanine; Amides; Amino Acids; Antiviral Agents; Catalytic Domain; COVID-19; COVID-19 Drug Treatment; Crystallography, X-Ray; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Dynamics Simulation; Nucleotides; Phosphoric Acids; Ribonuclease, Pancreatic; SARS-CoV-2 | 2020 |
Treatments for COVID-19: where are we now?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Immunologic Factors; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Were it business opportunities or hidden risks: Observations on clinical trials and marketing authorizations of Gilead Science's remdesivir in China.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; China; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Industry; Drugs, Generic; Economic Competition; Humans; Pandemics; Pneumonia, Viral | 2020 |
Use of remdesivir for pregnant patients with severe novel coronavirus disease 2019.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Coronavirus Infections; COVID-19; Female; Humans; Pandemics; Pneumonia, Viral; Pregnancy; Pregnancy Complications, Infectious; Treatment Outcome | 2020 |
Experts Discuss COVID-19-Remdesivir, Vaccines, and More.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Contact Tracing; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Dexamethasone; Disease Transmission, Infectious; Humans; Masks; Pandemics; Pneumonia, Viral; SARS-CoV-2; Viral Vaccines | 2020 |
Joint analysis of duration of ventilation, length of intensive care, and mortality of COVID-19 patients: a multistate approach.
Topics: Adenosine Monophosphate; Alanine; Algorithms; Antiviral Agents; Betacoronavirus; Cohort Studies; Compassionate Use Trials; Coronavirus Infections; COVID-19; Critical Care; Humans; Intensive Care Units; Length of Stay; Models, Theoretical; Pandemics; Pneumonia, Viral; Respiration, Artificial; SARS-CoV-2; Survival Analysis; Survival Rate; Time Factors | 2020 |
A Chemoenzymatic Synthesis of the (
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Caulobacteraceae; Coronavirus Infections; COVID-19; Humans; Molecular Structure; Pandemics; Phosphoric Triester Hydrolases; Pneumonia, Viral; RNA-Dependent RNA Polymerase; SARS-CoV-2; Virus Replication | 2020 |
Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study.
Topics: Adenosine Monophosphate; Age Factors; Aged; Alanine; Antiviral Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Betacoronavirus; Cardiovascular Diseases; Case-Control Studies; Cohort Studies; Comorbidity; Connective Tissue Diseases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Female; Glucocorticoids; Hospitalization; Humans; Hydroxychloroquine; Immunosuppressive Agents; Logistic Models; Lopinavir; Lupus Erythematosus, Systemic; Male; Middle Aged; Obesity; Pandemics; Pneumonia, Viral; Polymyalgia Rheumatica; Prognosis; Rheumatic Diseases; Risk Factors; Ritonavir; SARS-CoV-2; Severity of Illness Index; Sex Factors; Sjogren's Syndrome; Spondylarthropathies | 2020 |
Policy Implications of the Orphan Drug Designation for Remdesivir to Treat COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Orphan Drug Production; Pandemics; Pneumonia, Viral; SARS-CoV-2; United States; United States Food and Drug Administration | 2020 |
Bilateral posterior cerebral artery territory infarction in a SARS-Cov-2 infected patient: discussion about an unusual case.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Diagnosis, Differential; Fatal Outcome; Host-Pathogen Interactions; Humans; Infarction, Posterior Cerebral Artery; Male; Middle Aged; Pandemics; Pneumonia, Viral; Predictive Value of Tests; Risk Factors; SARS-CoV-2; Thrombolytic Therapy; Treatment Outcome | 2020 |
COVID-19 and remdesivir in pediatric patients: the invisible part of the iceberg.
Topics: Adenosine Monophosphate; Alanine; Child; COVID-19 Drug Treatment; Humans; Respiratory Insufficiency; SARS-CoV-2; Thrombocytopenia | 2021 |
A fatal case of coronavirus disease 2019 in a patient with common variable immunodeficiency.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Asthma; Common Variable Immunodeficiency; COVID-19; COVID-19 Serotherapy; Fatal Outcome; Humans; IgG Deficiency; Immunization, Passive; Immunoglobulin G; Immunoglobulins, Intravenous; Male; Methicillin-Resistant Staphylococcus aureus; Obesity, Morbid; SARS-CoV-2; Staphylococcal Infections | 2021 |
Efficacy of Remdesivir in COVID-19.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Female; Follow-Up Studies; Humans; Intensive Care Units; Italy; Male; Middle Aged; Pandemics; Pneumonia, Viral; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Treatment Outcome | 2020 |
Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia.
Topics: Adenosine Monophosphate; Airway Remodeling; Alanine; Animals; Antiviral Agents; Bronchi; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Diltiazem; Drug Synergism; Humans; Immunity, Innate; Models, Biological; Nose; Respiratory Mucosa; SARS-CoV-2; Vero Cells | 2020 |
Compassionate use of remdesivir for treatment of severe coronavirus disease 2019 in pregnant women at a United States academic center.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Clinical Decision-Making; Compassionate Use Trials; COVID-19; COVID-19 Drug Treatment; Drug Monitoring; Female; Humans; Infant, Newborn; Liver Function Tests; Neonatal Screening; Perinatology; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; SARS-CoV-2; Treatment Outcome | 2020 |
Allocating Remdesivir Under Scarcity: Social Justice or More Systemic Racism.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Healthcare Disparities; Humans; Pandemics; Pneumonia, Viral; Racism; SARS-CoV-2; Social Justice; United States | 2020 |
Preferential use of dexamethasone for fetal lung maturation in severe coronavirus disease 2019.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Compassionate Use Trials; COVID-19; Dexamethasone; Female; Fetal Organ Maturity; Glucocorticoids; Humans; Obesity; Oxygen Inhalation Therapy; Pregnancy; Respiratory Insufficiency; SARS-CoV-2; Severity of Illness Index; Treatment Outcome | 2020 |
Antiviral treatment for COVID-19: the evidence supporting remdesivir.
Topics: Adenosine Monophosphate; Administration, Intravenous; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Female; Humans; Male; Middle Aged; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; SARS-CoV-2 | 2020 |
Data Monitoring for the Chinese Clinical Trials of Remdesivir in Treating Patients with COVID-19 During the Pandemic Crisis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; China; Clinical Trials Data Monitoring Committees; Clinical Trials, Phase III as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Data Accuracy; Host Microbial Interactions; Humans; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; Research Design; SARS-CoV-2; Time Factors; Treatment Outcome | 2020 |
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; beta-Cyclodextrins; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Interactions; Furans; Humans; Intensive Care Units; Lung Transplantation; Multiple Organ Failure; Pandemics; Pneumonia, Viral; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines | 2020 |
Catalytic Asymmetric Synthesis of the anti-COVID-19 Drug Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Catalysis; COVID-19; COVID-19 Drug Treatment; Humans; Imidazoles; Kinetics; Molecular Conformation; SARS-CoV-2; Stereoisomerism | 2020 |
It Ain't Over Till It's Over: The Triple Threat of COVID-19, TB, and HIV.
Topics: Adenosine Monophosphate; Alanine; Antitubercular Agents; Antiviral Agents; Betacoronavirus; Coinfection; Comorbidity; Coronavirus Infections; COVID-19; Drug Interactions; HIV Infections; HIV-1; Humans; Mycobacterium tuberculosis; Pandemics; Pneumonia, Viral; Prevalence; Rifampin; SARS-CoV-2; Survival Analysis; Tuberculosis, Pulmonary; United States | 2020 |
Successful treatment with Remdesivir and corticosteroids in a patient with COVID-19-associated pneumonia: A case report.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Glucocorticoids; Humans; Male; Methylprednisolone; Middle Aged; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir and COVID-19: What are the implications for Africa?
Topics: Adenosine Monophosphate; Africa; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Emergency Use Authorization for Remdesivir and Its Potential Implications.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; Humans; SARS-CoV-2 | 2021 |
Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Disease Models, Animal; Drug Administration Schedule; Humans; Inflammation; Macaca mulatta; Models, Statistical; Pandemics; Pneumonia, Viral; SARS-CoV-2; Viral Load; Virus Replication | 2020 |
Remdesivir, a remedy or a ripple in severe COVID-19?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2020 |
Kidney Transplantation and COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Pandemics; Pneumonia, Viral; SARS-CoV-2; Transplant Recipients | 2020 |
Case of multisystem inflammatory syndrome in children presenting as fever and abdominal pain.
Topics: Abdominal Pain; Adenosine Monophosphate; Alanine; C-Reactive Protein; Child; COVID-19; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing; Diagnosis, Differential; Fever; Humans; Interleukin 1 Receptor Antagonist Protein; Intubation, Intratracheal; Male; Mucocutaneous Lymph Node Syndrome; Myocarditis; Nasopharynx; Natriuretic Peptide, Brain; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Tachycardia; Treatment Outcome | 2020 |
COVID-19 convalescent plasma clears SARS-CoV-2 refractory to remdesivir in an infant with congenital heart disease.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Neutralizing; Antiviral Agents; Coronavirus Infections; COVID-19; Down Syndrome; Female; Heart Diseases; Humans; Immunization, Passive; Infant; Pandemics; Pneumonia, Viral; Respiratory Insufficiency | 2020 |
Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Child; COVID-19; COVID-19 Drug Treatment; Evidence-Based Medicine; Humans; Immunocompromised Host; Risk Factors; Severity of Illness Index; Systemic Inflammatory Response Syndrome | 2021 |
COVID-19: Rescue by transcriptional inhibition.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Cytidine; Humans; Hydroxylamines; Pandemics; Pneumonia, Viral; Ribonucleosides; RNA-Dependent RNA Polymerase; SARS-CoV-2; Transcription, Genetic | 2020 |
Pulmonary administration of remdesivir in the treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Public Risk-Taking and Rewards During the COVID-19 Pandemic - A Case Study of Remdesivir in the Context of Global Health Equity.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Global Health; Humans; Pandemics; Reward; Risk-Taking | 2022 |
Severe COVID-19 Infections-Knowledge Gained and Remaining Questions.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Critical Care; Critical Care Outcomes; Extracorporeal Membrane Oxygenation; Hospital Mortality; Humans; Patient Positioning; Prone Position; Respiration, Artificial; Respiratory Distress Syndrome; SARS-CoV-2; Severity of Illness Index | 2021 |
Response to: Status of Remdesivir: Not Yet Beyond Question!
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Successfully treated severe COVID-19 and invasive aspergillosis in early hematopoietic cell transplantation setting.
Topics: Adenosine Monophosphate; Alanine; Amphotericin B; Coinfection; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Invasive Pulmonary Aspergillosis; Lung; Male; Methylprednisolone; Myeloablative Agonists; Nitriles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; Pyrimidines; SARS-CoV-2; Severity of Illness Index; Tomography, X-Ray Computed; Transplantation Conditioning; Treatment Outcome; Young Adult | 2021 |
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Apoptosis; Caco-2 Cells; Cathepsins; COVID-19; COVID-19 Drug Treatment; Heart Diseases; Host-Pathogen Interactions; Humans; Myocytes, Cardiac; Reactive Oxygen Species; SARS-CoV-2; Signal Transduction | 2020 |
Recognition of Potential COVID-19 Drug Treatments through the Study of Existing Protein-Drug and Protein-Protein Structures: An Analysis of Kinetically Active Residues.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antibodies, Viral; Antigen-Antibody Reactions; Antiviral Agents; Betacoronavirus; Binding Sites; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Eflornithine; Humans; Hydrophobic and Hydrophilic Interactions; Ivermectin; L-Lactate Dehydrogenase; Models, Molecular; Molecular Docking Simulation; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Proline; Protein Binding; Protein Conformation; Protein Interaction Mapping; Receptors, Glycine; Saposins; SARS-CoV-2; Sofosbuvir; Spike Glycoprotein, Coronavirus; Structure-Activity Relationship | 2020 |
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus RNA-Dependent RNA Polymerase; Models, Chemical; Mutation; Nucleotides; SARS-CoV-2; Templates, Genetic; Transcription Termination, Genetic; Virus Replication | 2020 |
Status of Remdesivir: Not Yet Beyond Question!
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.
Topics: Abdominal Pain; Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azithromycin; Chemical and Drug Induced Liver Injury; Chloroquine; COVID-19 Drug Treatment; Databases, Pharmaceutical; Diarrhea; Drug Combinations; Drug Eruptions; Drug Repositioning; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; Long QT Syndrome; Lopinavir; Male; Nausea; Oseltamivir; Ritonavir; Sex Distribution; Sex Factors; Vomiting | 2020 |
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response.
Topics: Adenosine Monophosphate; Alanine; Alveolar Epithelial Cells; Animals; Antiviral Agents; Cells, Cultured; COVID-19; Drug Development; Enzyme Inhibitors; Humans; Inflammation; Models, Biological; Pluripotent Stem Cells; RNA-Seq; SARS-CoV-2; Serine Endopeptidases; Virus Replication | 2020 |
Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Aged; Alanine; B-Lymphocytes; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Female; Humans; Immunization, Passive; Mutation; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2021 |
Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity".
Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung Transplantation; Neuroglia; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines | 2020 |
Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity.
Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines | 2020 |
Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Chloroquine; Digoxin; Inhibitory Concentration 50; Ouabain; SARS-CoV-2; Vero Cells; Virus Replication | 2020 |
Acetylcysteine for the Treatment of Suspected Remdesivir-Associated Acute Liver Failure in COVID-19: A Case Series.
Topics: Acetylcysteine; Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Fatal Outcome; Female; Humans; Liver Failure, Acute; Liver Function Tests; SARS-CoV-2; Treatment Outcome | 2020 |
Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antibodies, Viral; Antiviral Agents; B-Lymphocytes; COVID-19; Hospitalization; Humans; Interleukin-6; Male; NF-kappa B p52 Subunit; Respiration, Artificial; SARS-CoV-2; Severity of Illness Index | 2021 |
Compassionate Drug Use - Time Arising for a New Law in Bulgaria in the Era of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Bulgaria; Compassionate Use Trials; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drugs, Investigational; Health Policy; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir and COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir and COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir and COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Double-Blind Method; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Remdesivir and COVID-19 - Authors' reply.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; Ribonucleotides; SARS-CoV-2 | 2020 |
Quality of adverse event reporting in clinical trials of remdesivir in patients with COVID-19.
Topics: Adenosine Monophosphate; Adverse Drug Reaction Reporting Systems; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Humans; Quality Indicators, Health Care; Research Design; Risk Assessment | 2021 |
Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 1).
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Administration Schedule; Evidence-Based Medicine; Humans; SARS-CoV-2; Severity of Illness Index | 2021 |
Fatal outcome of anti-MDA5 juvenile dermatomyositis in a paediatric COVID-19 patient: a case report.
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antiviral Agents; Autoantibodies; Bronchoscopy; Child; COVID-19; COVID-19 Nucleic Acid Testing; Cyclophosphamide; Dermatomyositis; Disease Progression; Fatal Outcome; Female; Humans; Hydroxychloroquine; Immunocompromised Host; Immunoglobulins, Intravenous; Immunologic Factors; Immunosuppressive Agents; Interferon-Induced Helicase, IFIH1; Lung; Lung Diseases, Interstitial; Lymphohistiocytosis, Hemophagocytic; Mediastinal Emphysema; Methylprednisolone; Piperidines; Pneumonia, Pneumocystis; Pneumothorax; Pyrimidines; Respiratory Insufficiency; Shock, Septic; Subcutaneous Emphysema; Tomography, X-Ray Computed; Trimethoprim, Sulfamethoxazole Drug Combination | 2021 |
Origins and Ownership of Remdesivir: Implications for Pricing.
Topics: Adenosine Monophosphate; Alanine; Coronavirus Infections; COVID-19 Drug Treatment; Drug Discovery; Drug Repositioning; History, 21st Century; Humans; Intellectual Property; Ownership; SARS-CoV-2; United States | 2020 |
Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Drug Discovery; Drug Repositioning; Exonucleases; Hepacivirus; Hepatitis C; Humans; Pandemics; Pneumonia, Viral; Prodrugs; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Sofosbuvir; Viral Nonstructural Proteins; Virus Replication | 2020 |
Audio Interview: Covid-19 and the President.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Federal Government; Glucocorticoids; Government Employees; HIV Protease Inhibitors; Humans; Hypoxia; Immunization, Passive; Lopinavir; Oxygen Inhalation Therapy; Pandemics; Patient Acuity; Pneumonia, Viral; Risk Assessment; SARS-CoV-2; United States; Virus Replication | 2020 |
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Cell Line; Drug Tolerance; Ebolavirus; Humans; Models, Molecular; Mutation; RNA-Dependent RNA Polymerase; SARS-CoV-2; Viral Nonstructural Proteins; Virus Replication | 2020 |
Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Adult; Alanine; Compassionate Use Trials; COVID-19 Drug Treatment; Female; Humans; Infant; Oxygen Saturation; Pregnancy; Pregnancy Complications, Infectious; Pregnant Women; SARS-CoV-2 | 2021 |
Severe COVID-19 initially presenting as mesenteric adenopathy.
Topics: Abdominal Pain; Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; COVID-19; COVID-19 Testing; Diagnosis, Differential; Humans; Lymphadenopathy; Male; Peritoneal Diseases; Polymerase Chain Reaction; Positive-Pressure Respiration; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Kidney; Liver; Lung; Male; Mice; Nucleosides; Nucleotides; Polyphosphates; SARS-CoV-2; Tissue Distribution | 2021 |
Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection.
Topics: Adenosine Monophosphate; Alanine; Alphacoronavirus; Animals; Cells, Cultured; Chlorocebus aethiops; Coronavirus Infections; Disease Susceptibility; Gene Expression; Host Specificity; Humans; Luminescent Proteins; Mice; Vero Cells; Virus Replication | 2020 |
Management and outcomes of patients hospitalized with severe COVID-19 at a tertiary care center in midwestern United States.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Anticoagulants; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Critical Care; Glucocorticoids; Hospitalization; Humans; Immunization, Passive; Midwestern United States; Pandemics; Pneumonia, Viral; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Tertiary Care Centers; Tertiary Healthcare | 2020 |
Psychiatric Disorders and Hydroxychloroquine for Coronavirus Disease 2019 (COVID-19): A VigiBase Study.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19 Drug Treatment; Databases, Pharmaceutical; Drug Combinations; Female; Hallucinations; Humans; Hydroxychloroquine; Lopinavir; Male; Mental Disorders; Middle Aged; Psychoses, Substance-Induced; Ritonavir; Self-Injurious Behavior; Suicide; Suicide, Attempted; Young Adult | 2020 |
Cyanoamidine Cyclization Approach to Remdesivir's Nucleobase.
Topics: Adenosine Monophosphate; Alanine; Amidines; Antiviral Agents; Chemistry Techniques, Synthetic; Coronavirus Infections; COVID-19; Cyclization; Pandemics; Pneumonia, Viral | 2020 |
Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Viral; COVID-19; Hospitalization; Humans; Immunity, Humoral; Immunocompromised Host; Lymphoma, Mantle-Cell; Male; Middle Aged; Primary Immunodeficiency Diseases; SARS-CoV-2; Seroconversion; Virus Replication | 2021 |
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antimalarials; Antiviral Agents; Chlorocebus aethiops; Chloroquine; COVID-19; COVID-19 Drug Treatment; Electrocardiography; Flow Cytometry; Heart Diseases; Humans; Hydroxychloroquine; Microscopy, Fluorescence; Myocytes, Cardiac; Pluripotent Stem Cells; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Vero Cells; Viral Plaque Assay | 2020 |
Global trial eliminates drugs, pivots to new ones.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Interferon-beta; Randomized Controlled Trials as Topic; World Health Organization | 2020 |
Anti-infective therapy against SARS-CoV-2: some light at the end of the tunnel?
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antiparasitic Agents; Antiviral Agents; COVID-19 Drug Treatment; Drug Development; Drug Repositioning; Humans; SARS-CoV-2; Virus Physiological Phenomena | 2020 |
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response.
Topics: Adenosine Monophosphate; Adoptive Transfer; Alanine; Antibodies, Viral; Antiviral Agents; Broadly Neutralizing Antibodies; Cell- and Tissue-Based Therapy; COVID-19; COVID-19 Drug Treatment; Humans; Hydrazines; Killer Cells, Natural; Models, Theoretical; SARS-CoV-2; Time Factors; Treatment Outcome; Triazoles; Viral Load; Virus Shedding | 2020 |
Exploring RdRp-remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Molecular Docking Simulation; Pandemics; Pneumonia, Viral; Quantitative Structure-Activity Relationship; RNA-Dependent RNA Polymerase; SARS-CoV-2; Viral Proteins | 2020 |
Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum Computations.
Topics: Adenosine Monophosphate; Alanine; Antimetabolites; Antiviral Agents; China; COVID-19; COVID-19 Drug Treatment; Dioxolanes; Fluoroquinolones; Humans; Methyltransferases; Molecular Docking Simulation; Nelfinavir; Phytochemicals; Piperazines; Protein Conformation; RNA Helicases; SARS-CoV-2; Topoisomerase II Inhibitors; Viral Nonstructural Proteins | 2020 |
Sustained Response After Remdesivir and Convalescent Plasma Therapy in a B-Cell-Depleted Patient With Protracted Coronavirus Disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Humans; Immunization, Passive; SARS-CoV-2 | 2021 |
The Binding of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase May Pave The Way Towards the Design of Potential Drugs for COVID-19 Treatment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pharmaceutical Preparations; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2 | 2021 |
Development of a Simple
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus RNA-Dependent RNA Polymerase; Drug Evaluation, Preclinical; Nucleotides; RNA; RNA, Viral; Viral Nonstructural Proteins | 2020 |
Remdesivir for the Treatment of Severe COVID-19: A Community Hospital's Experience.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Combined Modality Therapy; COVID-19; COVID-19 Drug Treatment; Critical Care; Female; Hospital Mortality; Hospitalization; Hospitals, Community; Humans; Male; Middle Aged; Retrospective Studies; SARS-CoV-2; Treatment Outcome | 2020 |
Identification of potential COVID-19 main protease inhibitors using structure-based pharmacophore approach, molecular docking and repurposing studies.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Crystallography, X-Ray; Drug Discovery; Drug Repositioning; Humans; Models, Chemical; Molecular Docking Simulation; Molecular Structure; Pandemics; Pneumonia, Viral; Protease Inhibitors; Structure-Activity Relationship | 2021 |
Impact of Trump's Promotion of Unproven COVID-19 Treatments and Subsequent Internet Trends: Observational Study.
Topics: Adenosine Monophosphate; Alanine; Azithromycin; Chloroquine; Communication; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Federal Government; Fraud; Humans; Hydroxychloroquine; Internet; Language; Mass Media; Pandemics; Pneumonia, Viral; Public Health; United States | 2020 |
Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on haemodialysis.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Furans; Humans; Kidney Failure, Chronic; Pyrroles; Renal Dialysis; Triazines | 2021 |
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Monoclonal; Antimetabolites; Antiviral Agents; Autophagy; Betacoronavirus; COVID-19; Dexamethasone; Disease Outbreaks; Drug Development; Humans; Mice; Pandemics; SARS-CoV-2; Signal Transduction; Virus Internalization | 2020 |
'A very, very bad look' for remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Drug Approval; Drug Industry; Europe; Humans; Investments; Treatment Failure; United States; United States Food and Drug Administration | 2020 |
Scientists criticize use of unproven COVID drugs in India.
Topics: Adenosine Monophosphate; Alanine; Amides; Antibodies, Monoclonal, Humanized; Clinical Trials, Phase III as Topic; Controlled Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; Drugs, Investigational; Humans; Hydroxychloroquine; India; Patient Safety; Placebos; Pyrazines; Reproducibility of Results; SARS-CoV-2; Time Factors; United States; Virus Shedding | 2020 |
The Challenges Ahead With Monoclonal Antibodies: From Authorization to Access.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Humans; Pandemics; United States | 2020 |
Why do COVID death rates seem to be falling?
Topics: Adenosine Monophosphate; Age Distribution; Age Factors; Aged; Aged, 80 and over; Alanine; Antibodies, Monoclonal, Humanized; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Dexamethasone; Humans; Immunization, Passive; Intensive Care Units; Oxygen; Pandemics; Pneumonia, Viral; Respiratory Distress Syndrome; SARS-CoV-2; Time Factors; Ventilators, Mechanical | 2020 |
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Synergism; Humans; Models, Molecular; Recombinant Proteins; SARS-CoV-2; Vero Cells; Virus Internalization; Virus Replication | 2021 |
Safe and effective medication utilization in pediatric patients requiring rehabilitation services during the Coronavirus pandemic of 2019.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Child; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Drug Discovery; Humans; Hydroxychloroquine; Off-Label Use; Pandemics; Pediatrics; Public-Private Sector Partnerships; Rehabilitation; Research Support as Topic; United States | 2020 |
Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Binding Sites; Coronavirus Papain-Like Proteases; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Protein Conformation; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids.
Topics: Adenosine Monophosphate; Alanine; Caco-2 Cells; COVID-19; COVID-19 Drug Treatment; Human Embryonic Stem Cells; Humans; Intestinal Mucosa; Organoids; SARS-CoV-2; Virus Replication | 2021 |
SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down Syndrome.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Child, Preschool; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Critical Care; Down Syndrome; Genetic Predisposition to Disease; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Lymphohistiocytosis, Hemophagocytic; Male; Prednisolone; SARS-CoV-2; Systemic Inflammatory Response Syndrome | 2021 |
Revealing the Inhibition Mechanism of RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 by Remdesivir and Nucleotide Analogues: A Molecular Dynamics Simulation Study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Caco-2 Cells; Catalytic Domain; Coronavirus RNA-Dependent RNA Polymerase; Density Functional Theory; Enzyme Inhibitors; Humans; Hydrogen Bonding; Models, Chemical; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; SARS-CoV-2; Thermodynamics | 2020 |
Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Female; Humans; Hydroxychloroquine; Inflammation; Intensive Care Units; Interleukin-10; Interleukin-6; Interleukin-8; Italy; Leukocytes; Leukocytes, Mononuclear; Lopinavir; Lung; Lymphocytes; Macrophages, Alveolar; Male; Microscopy, Electron, Transmission; Middle Aged; Neutrophils; Pandemics; Pneumonia, Viral; Prognosis; Prospective Studies; Respiration, Artificial; Ritonavir; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Survival Rate; Virion | 2020 |
Compassionate use of remdesivir in children with COVID-19.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Child; Child, Preschool; Compassionate Use Trials; COVID-19 Drug Treatment; Critical Illness; Female; Humans; Infant; Male; Severity of Illness Index; Spain; Treatment Outcome | 2021 |
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; ATPases Associated with Diverse Cellular Activities; Cell Cycle Proteins; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; Furans; Hep G2 Cells; Humans; Mass Spectrometry; Proteomics; Pyrroles; Triazines; United States; United States Food and Drug Administration | 2021 |
Hydration-Induced Disorder Lowers the Energy Barriers for Methyl Rotation in Drug Molecules.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; Crystallography, X-Ray; Dexamethasone; Hydroxychloroquine; Methylation; Models, Molecular; Water | 2020 |
A Patient with Fever and Dyspnea.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Combined Modality Therapy; COVID-19; Dexamethasone; Diagnosis, Differential; Dyspnea; Female; Fever; Humans; Leukocyte Count; Lung; Middle Aged; Myalgia; Nasopharynx; Oxygen; Radiography, Thoracic; Respiration, Artificial; Respiratory Distress Syndrome; SARS-CoV-2 | 2020 |
Audio Interview: What the U.S. Response to Covid-19 Looks Like Today.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antiviral Agents; Asymptomatic Diseases; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Dexamethasone; Disease Transmission, Infectious; Drug Development; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Treatment Outcome; Viral Vaccines | 2020 |
Covid-19-Associated Myopathy Caused by Type I Interferonopathy.
Topics: Adenosine Monophosphate; Adult; Alanine; COVID-19; Humans; Interferon Type I; Male; Methylprednisolone; Muscle, Skeletal; Muscular Diseases; Myxovirus Resistance Proteins; Prednisone | 2020 |
A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Chromosomes, Artificial, Bacterial; COVID-19; COVID-19 Drug Treatment; HEK293 Cells; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Replicon; RNA-Binding Proteins; SARS-CoV-2; Sofosbuvir; Vero Cells; Virus Replication | 2021 |
Is remdesivir important in clinical practice as a treatment of COVID-19? A study based on meta-analysis data.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Reference Standards; SARS-CoV-2 | 2021 |
Remdesivir: a pendulum in a pandemic.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome | 2020 |
Management of an Immunocompromised Pediatric Patient With Multiple Hospitalizations for Symptomatic COVID-19.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Disease Management; Female; Hospitalization; Humans; Immunocompromised Host; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; SARS-CoV-2 | 2022 |
The place for remdesivir in COVID-19 treatment.
Topics: Adenosine Monophosphate; Adult; Alanine; COVID-19 Drug Treatment; Double-Blind Method; Humans; SARS-CoV-2 | 2021 |
Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent haemodialysis.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Male; Renal Dialysis | 2021 |
Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications.
Topics: Adenosine Monophosphate; Adverse Drug Reaction Reporting Systems; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Databases, Factual; Humans; SARS-CoV-2; World Health Organization | 2021 |
Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Protein Conformation; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2021 |
Remdesivir Strongly Binds to Both RNA-Dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations.
Topics: Adenosine Monophosphate; Alanine; Algorithms; Antiviral Agents; Coronavirus 3C Proteases; Humans; Hydrogen Bonding; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; RNA-Dependent RNA Polymerase; SARS-CoV-2; Static Electricity | 2020 |
FDA Approval of Remdesivir - A Step in the Right Direction.
Topics: Adenosine Monophosphate; Adolescent; Adult; Alanine; Antiviral Agents; Child; Clinical Trials, Phase III as Topic; COVID-19 Drug Treatment; Drug Approval; Humans; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration | 2020 |
Risk of congenital birth defects during COVID-19 pandemic: Draw attention to the physicians and policymakers.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Congenital Abnormalities; COVID-19; COVID-19 Drug Treatment; Female; Global Health; Humans; Hydroxychloroquine; Infant, Newborn; Infant, Newborn, Diseases; Neural Tube Defects; Physicians; Pregnancy; Pregnancy Complications, Infectious; SARS-CoV-2 | 2020 |
[Nursing Experience Caring for a COVID-19 Patient With Hearing Loss].
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Communication; Coronavirus Infections; COVID-19; Hearing Loss; Humans; Male; Pandemics; Patient-Centered Care; Pneumonia, Viral; SARS-CoV-2; Social Isolation; Taiwan; Treatment Outcome | 2020 |
Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC-MS/MS.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Humans; Liver; Male; Mice; Prodrugs; Tandem Mass Spectrometry | 2021 |
The Adaptive COVID-19 Treatment Trial-1 (ACTT-1) in a real-world population: a comparative observational study.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Pandemics; SARS-CoV-2 | 2020 |
A survey of US hospitals' criteria for the allocation of remdesivir to treat COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cross-Sectional Studies; Health Personnel; Humans; Patient Care Team; Pharmacists; Pharmacy Service, Hospital; Resource Allocation; Surveys and Questionnaires; United States | 2021 |
IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; Clinical Trials, Phase II as Topic; COVID-19 Drug Treatment; Dihydroorotate Dehydrogenase; Drug Discovery; Drug Repositioning; Drug Synergism; Humans; Oxidoreductases Acting on CH-CH Group Donors; SARS-CoV-2; Vero Cells; Virus Replication | 2020 |
Molecular Descriptors of Some Chemicals that Prevent COVID-19.
Topics: Adenosine Monophosphate; Alanine; Biflavonoids; Catechin; COVID-19; Humans; Hydroxychloroquine; Quantitative Structure-Activity Relationship; SARS-CoV-2 | 2021 |
A mechanism-based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID-19 treatment in humans.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cells, Cultured; COVID-19; COVID-19 Drug Treatment; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Respiratory Mucosa; Species Specificity | 2021 |
Structure-aided ACEI-capped remdesivir-loaded novel PLGA nanoparticles: toward a computational simulation design for anti-SARS-CoV-2 therapy.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; COVID-19 Drug Treatment; Drug Carriers; Drug Synergism; Humans; Lisinopril; Molecular Docking Simulation; Molecular Dynamics Simulation; Nanoparticles; Polylactic Acid-Polyglycolic Acid Copolymer; Protein Binding; SARS-CoV-2 | 2020 |
Gender differences in treatment of Coronavirus Disease-2019.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Amides; Antimalarials; Antiviral Agents; Cardiovascular Diseases; Chloroquine; Clinical Trials as Topic; Combined Modality Therapy; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Diabetes Complications; Female; Humans; Hypertension; Immunity; Immunization, Passive; Immunoglobulins; Lopinavir; Male; Middle Aged; Mortality; Pandemics; Pyrazines; Ritonavir; SARS-CoV-2; Sex Characteristics | 2020 |
Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia in a Newborn Treated With Remdesivir and Coronavirus Disease 2019 Convalescent Plasma.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; COVID-19; COVID-19 Serotherapy; Female; Humans; Immunization, Passive; Infant, Newborn; Infectious Disease Transmission, Vertical; Pneumonia, Viral; SARS-CoV-2 | 2021 |
Are academia-pharma partnerships essential for novel drug discovery in the time of the COVID-19 pandemic?
Topics: Academic Medical Centers; Adenosine Monophosphate; Alanine; Antiviral Agents; Bias; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Drug Discovery; Drug Industry; Humans; Public-Private Sector Partnerships; Research; Research Support as Topic; SARS-CoV-2; Universities | 2021 |
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Alveolar Epithelial Cells; Antibodies, Neutralizing; COVID-19; COVID-19 Drug Treatment; Down-Regulation; Drug Discovery; Human Embryonic Stem Cells; Humans; Immunity; Lipid Metabolism; Lung; RNA, Viral; SARS-CoV-2; Virus Replication | 2021 |
Remdesivir Use in the Setting of Severe Renal Impairment: A Theoretical Concern or Real Risk?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Retrospective Studies; SARS-CoV-2 | 2021 |
Use of Intravenous Immunoglobulin (Prevagen or Octagam) for the Treatment of COVID-19: Retrospective Case Series.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Adult; Aged; Alanine; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antiviral Agents; APACHE; Azithromycin; COVID-19; COVID-19 Drug Treatment; Doxycycline; Enzyme Inhibitors; Extracorporeal Membrane Oxygenation; Female; Humans; Hydroxychloroquine; Immunoglobulins, Intravenous; Immunologic Factors; Intensive Care Units; Length of Stay; Lopinavir; Male; Middle Aged; Respiration, Artificial; Retrospective Studies; Severity of Illness Index; Time Factors; Young Adult | 2020 |
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19; Fever; Humans; Immunity, Humoral; Lymphocyte Count; Male; SARS-CoV-2; Treatment Outcome | 2020 |
The safety of remdesivir for COVID-19 patients.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Network Meta-Analysis; SARS-CoV-2 | 2021 |
[The medicinal treatment of COVID-19: a brief update].
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Glucocorticoids; Humans; Hydroxychloroquine; Netherlands; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome | 2020 |
Synergistic and Antagonistic Drug Combinations against SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Drug Synergism; Humans; Hydroxychloroquine; SARS-CoV-2 | 2021 |
Remdesivir and Acute Renal Failure: A Potential Safety Signal From Disproportionality Analysis of the WHO Safety Database.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Odds Ratio; Pharmacovigilance; SARS-CoV-2; World Health Organization | 2021 |
Remdesivir for COVID-19 in Europe: will it provide value for money?
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antiviral Agents; Cost-Benefit Analysis; COVID-19 Drug Treatment; Drug Combinations; Europe; Humans | 2021 |
Remdesivir Approved to Treat COVID-19 Amid Controversy.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Drug Approval; Humans; United States; United States Food and Drug Administration | 2021 |
Advantages of visualisations to evaluate and communicate adverse event information in randomised controlled trials.
Topics: Adenosine Monophosphate; Alanine; Antiparkinson Agents; Antiviral Agents; Computer Graphics; COVID-19 Drug Treatment; Data Accuracy; Data Analysis; Data Display; Data Visualization; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Glial Cell Line-Derived Neurotrophic Factor; Humans; Parkinson Disease; Randomized Controlled Trials as Topic; Research Design | 2020 |
On the molecular structure of Remdesivir for the treatment of Covid-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Humans; Models, Molecular; Molecular Structure; SARS-CoV-2; Vero Cells | 2021 |
Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Female; Humans; Immunocompromised Host; SARS-CoV-2; Virus Replication | 2021 |
Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Carboxylesterase; COVID-19 Drug Treatment; Drug Interactions; Enzyme Inhibitors; Humans; Microsomes; Pharmaceutical Preparations; Tenofovir | 2021 |
Extracorporeal Membrane Oxygenation for COVID-19-Associated Multisystem Inflammatory Syndrome in a 5-year-old.
Topics: Adenosine Monophosphate; Adrenergic alpha-Agonists; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Child, Preschool; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Epinephrine; Extracorporeal Membrane Oxygenation; Female; Humans; Hypotension; Immunization, Passive; Immunoglobulins, Intravenous; Interleukin 1 Receptor Antagonist Protein; Methylprednisolone; Norepinephrine; Shock, Cardiogenic; Systemic Inflammatory Response Syndrome | 2022 |
Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections.
Topics: Adenosine Monophosphate; Alanine; Amaryllidaceae Alkaloids; Animals; Antiviral Agents; Chlorocebus aethiops; Hydrogen Bonding; Middle East Respiratory Syndrome Coronavirus; Molecular Docking Simulation; Phenanthridines; RNA-Dependent RNA Polymerase; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus; Vero Cells; Viral Proteins | 2021 |
Remdesivir-based therapy improved the recovery of patients with COVID-19 in the multicenter, real-world SARSTer study.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Female; Humans; Lopinavir; Male; Middle Aged; Poland; Risk Factors; Ritonavir; Severity of Illness Index; Treatment Outcome | 2021 |
The anti-HCV, Sofosbuvir, versus the anti-EBOV Remdesivir against SARS-CoV-2 RNA dependent RNA polymerase in silico.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Sofosbuvir | 2022 |
Essential medicine selection during the COVID-19 pandemic: Enabling access in uncharted territory.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Decision Making; Dexamethasone; Drugs, Essential; Evidence-Based Medicine; Glucocorticoids; Humans; Policy Making; Practice Guidelines as Topic; SARS-CoV-2; Severity of Illness Index; South Africa; Time Factors | 2020 |
Hybrid physiologically-based pharmacokinetic model for remdesivir: Application to SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Models, Biological; SARS-CoV-2 | 2021 |
Remdesivir for COVID-19 pneumonia: still undecided, but it might all be about adequate timing.
Topics: Adenosine Monophosphate; Airway Management; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Disease Progression; Humans; Hypoxia; Mortality; Patient Selection; Pneumonia, Viral; Randomized Controlled Trials as Topic; Respiratory Insufficiency; SARS-CoV-2; Time-to-Treatment; Treatment Outcome | 2021 |
COVID-19 FAQs in paediatric and congenital cardiology: AEPC position paper.
Topics: Adenosine Monophosphate; Alanine; Anti-Arrhythmia Agents; Anticoagulants; Antiviral Agents; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Surgical Procedures; Cardiology; COVID-19; COVID-19 Drug Treatment; Heart Defects, Congenital; Heart Transplantation; Humans; Immunologic Factors; Infectious Disease Transmission, Vertical; Long QT Syndrome; Myocarditis; Myocardium; Pediatrics; Risk Assessment; SARS-CoV-2; Societies, Medical; Systemic Inflammatory Response Syndrome; Tachycardia, Ventricular | 2021 |
Remdesivir for patients with COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chemical and Drug Induced Liver Injury; COVID-19 Drug Treatment; Critical Care; Drug Hypersensitivity; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
[Clinical progression of the first wave of novel coronavirus infection in Ostrava].
Topics: Adenosine Monophosphate; Aged; Alanine; Amides; COVID-19; Czech Republic; Female; Humans; Hydroxychloroquine; Length of Stay; Male; Pyrazines; Respiration, Artificial | 2020 |
Remdesivir and COVID-19 infection, therapeutic benefits or unnecessary risks?
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans | 2021 |
Research shows racial disparity, mortality data for patients with cancer and COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Black or African American; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Healthcare Disparities; Humans; Hydroxychloroquine; Mortality; Neoplasms; Race Factors; United Kingdom; United States | 2021 |
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Aptamers, Nucleotide; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Nucleotides; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Virus Replication | 2021 |
Remdesivir and mortality reduction in COVID-19 patients: a systematized subgroup analysis of clinical trials.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic | 2021 |
Remdesivir (Veklury) for COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Drug Interactions; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Randomized Controlled Trials as Topic | 2020 |
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Autophagy; Benzimidazoles; Bronchi; Cell Line; Coronavirus 229E, Human; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Epithelial Cells; Humans; Interferon Type I; Lung; Membrane Proteins; SARS-CoV-2; Virus Replication | 2021 |
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Apolipoproteins E; Astrocytes; Brain; Cell Differentiation; Chlorocebus aethiops; COVID-19; Humans; Induced Pluripotent Stem Cells; Nerve Degeneration; Neurites; Neurons; Organoids; Protein Isoforms; SARS-CoV-2; Synapses; Tropism; Vero Cells | 2021 |
An EUA for baricitinib (Olumiant) for COVID-19.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; Azetidines; Child; COVID-19 Drug Treatment; Drug Approval; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Purines; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; United States; United States Food and Drug Administration | 2020 |
Deep vein thrombosis with pulmonary thromboembolism in a case of severe COVID-19 pneumonia.
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Anticoagulants; Antiparasitic Agents; Antiviral Agents; Computed Tomography Angiography; COVID-19; COVID-19 Drug Treatment; Diabetes Mellitus, Type 2; Doxycycline; Femoral Vein; Fibrin Fibrinogen Degradation Products; Glucocorticoids; Heparin, Low-Molecular-Weight; Humans; Ivermectin; Male; Methylprednisolone; Middle Aged; Oxygen Inhalation Therapy; Popliteal Vein; Pulmonary Embolism; SARS-CoV-2; Tomography, X-Ray Computed; Ultrasonography, Doppler, Color; Venous Thrombosis | 2021 |
A prospective, observational study to evaluate adverse drug reactions in patients with COVID-19 treated with remdesivir or hydroxychloroquine: a preliminary report.
Topics: Adenosine Monophosphate; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Alanine; Antiviral Agents; Cohort Studies; COVID-19; COVID-19 Drug Treatment; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; Incidence; Inpatients; Male; Middle Aged; Monitoring, Physiologic; Pharmacovigilance; Portugal; Prospective Studies | 2021 |
Improving SARS-CoV-2 structures: Peer review by early coordinate release.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Viral; Catalytic Domain; DNA-Directed RNA Polymerases; Humans; Models, Molecular; Nucleocapsid; Peer Review; Phosphoproteins; RNA-Binding Proteins; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Zinc | 2021 |
Streptococcus pneumoniae coinfection in hospitalised patients with COVID-19.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Alanine; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antiviral Agents; Azithromycin; Ceftriaxone; Coinfection; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Dexamethasone; Female; Humans; Hydroxychloroquine; Male; Middle Aged; Pneumococcal Infections; SARS-CoV-2; Streptococcus pneumoniae | 2021 |
Severe sinus bradycardia associated with remdesivir in a child with severe SARS-COV-2 infection-reply.
Topics: Adenosine Monophosphate; Alanine; Bradycardia; Child; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses
Topics: Adenosine Monophosphate; Alanine; Animals; Antimetabolites; Antiviral Agents; Azo Compounds; Chlorocebus aethiops; Coronavirus NL63, Human; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Humans; Isoquinolines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolinones; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
Prediction of adverse drug reactions using drug convolutional neural networks.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Databases, Pharmaceutical; Deep Learning; Dexamethasone; Drug-Related Side Effects and Adverse Reactions; Humans; Neural Networks, Computer | 2021 |
Is it safe to use remdesivir in combination with a combined p-glycoprotein and CYP3A4 inhibitor?
Topics: Adenosine Monophosphate; Alanine; ATP Binding Cassette Transporter, Subfamily B; Chemical and Drug Induced Liver Injury; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; SARS-CoV-2 | 2021 |
Immune Profiling to Determine Early Disease Trajectories Associated With Coronavirus Disease 2019 Mortality Rate: A Substudy from the ACTT-1 Trial.
Topics: Adenosine Monophosphate; Adult; Alanine; Antibodies, Viral; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytokines; Female; Humans; Immunity; Male; SARS-CoV-2 | 2021 |
Allergen fragrance molecules: a potential relief for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Allergens; Benzopyrans; Benzyl Compounds; Cinnamates; Coronavirus 3C Proteases; Coronavirus Nucleocapsid Proteins; COVID-19; COVID-19 Drug Treatment; Diterpenes; Drug Evaluation, Preclinical; Humans; Ligands; Molecular Docking Simulation; Odorants; Perfume; Phosphoproteins; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Transcription Factors | 2021 |
Developing statewide remdesivir use criteria.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pharmacy Service, Hospital; Practice Guidelines as Topic; SARS-CoV-2; Utah | 2021 |
Severe sinus bradycardia associated with Remdesivir in a child with severe SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Bradycardia; Child; Compassionate Use Trials; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Available drugs and supplements for rapid deployment for treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Repositioning; Flavonoids; Humans; Mice; Nitro Compounds; Pharmaceutical Preparations; SARS-CoV-2; Small Molecule Libraries; Teicoplanin; Thiazoles | 2021 |
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus Nucleocapsid Proteins; COVID-19; COVID-19 Drug Treatment; Depsipeptides; Drug Evaluation, Preclinical; Female; HEK293 Cells; Humans; Lung; Mice, Inbred C57BL; Mutation; Peptide Elongation Factor 1; Peptides, Cyclic; Phosphoproteins; RNA, Viral; SARS-CoV-2; Virus Replication | 2021 |
Audio Interview: Covid-19 in South Africa and a New SARS-CoV-2 Variant.
Topics: Adenosine Monophosphate; Africa; Age Factors; Alanine; Antibodies, Neutralizing; Azabicyclo Compounds; Communicable Disease Control; COVID-19; COVID-19 Testing; COVID-19 Vaccines; Dexamethasone; Disease Transmission, Infectious; Humans; Immunization Programs; Mutation; Patient Acuity; Quinazolines; Risk Factors; SARS-CoV-2; Sequence Analysis, RNA; South Africa; Virulence | 2021 |
A PCR amplicon-based SARS-CoV-2 replicon for antiviral evaluation.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; CHO Cells; COVID-19; Cricetulus; Drug Design; Drug Evaluation, Preclinical; Electroporation; Genome, Viral; HEK293 Cells; Humans; Inhibitory Concentration 50; Kinetics; Open Reading Frames; Polymerase Chain Reaction; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Untranslated Regions; Vero Cells; Virion; Virus Replication | 2021 |
Physiologically-Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID-19.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Area Under Curve; Body Weight; Child; Child, Preschool; Computer Simulation; COVID-19 Drug Treatment; Drug Dosage Calculations; Female; Humans; Infant; Male; Models, Biological; Pandemics; SARS-CoV-2 | 2021 |
Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Epithelium; Humans; Interferons; Interleukin-6; Lung; SARS-CoV-2; Viral Tropism; Virus Replication | 2021 |
Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, High Pressure Liquid; COVID-19 Drug Treatment; Drug Monitoring; Furans; Humans; Limit of Detection; Pyrroles; Tandem Mass Spectrometry; Triazines | 2021 |
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Coronavirus Protease Inhibitors; COVID-19 Drug Treatment; Humans; Indoles; Pyridines; SARS-CoV-2; Vero Cells; Viral Proteases | 2021 |
Early remdesivir treatment in COVID-19: Why wait another day?
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Male; Time-to-Treatment | 2021 |
In inpatients with COVID-19, none of remdesivir, hydroxychloroquine, lopinavir, or interferon β-1a differed from standard care for in-hospital mortality.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Female; Hospital Mortality; Hospitalization; Humans; Hydroxychloroquine; Intention to Treat Analysis; Interferon beta-1a; Kaplan-Meier Estimate; Length of Stay; Lopinavir; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Respiration, Artificial; Treatment Failure; World Health Organization | 2021 |
Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Viral; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Macrophages; Male; Mesocricetus; Methylprednisolone; Respiratory System; RNA, Viral; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Viral Load; Virus Replication | 2021 |
Self-injectable extended release formulation of Remdesivir (SelfExRem): A potential formulation alternative for COVID-19 treatment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Delayed-Action Preparations; Drug Evaluation, Preclinical; Humans; Injections, Subcutaneous; Prodrugs; SARS-CoV-2 | 2021 |
Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysis.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Bayes Theorem; COVID-19; COVID-19 Drug Treatment; Humans; Probability; Respiration, Artificial; SARS-CoV-2 | 2021 |
SARS-CoV-2 evolution during treatment of chronic infection.
Topics: Adenosine Monophosphate; Aged; Alanine; Antibodies, Neutralizing; Antibodies, Viral; Chronic Disease; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Evolution, Molecular; Genome, Viral; High-Throughput Nucleotide Sequencing; Humans; Immune Evasion; Immune Tolerance; Immunization, Passive; Immunosuppression Therapy; Male; Mutagenesis; Mutant Proteins; Mutation; Phylogeny; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Time Factors; Viral Load; Virus Shedding | 2021 |
A Patient with X-Linked Agammaglobulinemia and COVID-19 Infection Treated with Remdesivir and Convalescent Plasma.
Topics: Adenosine Monophosphate; Adult; Agammaglobulinemia; Alanine; COVID-19; COVID-19 Serotherapy; Genetic Diseases, X-Linked; Humans; Immunization, Passive; Male | 2021 |
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum
Topics: Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Chloroquine; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Furans; Humans; Hydroxychloroquine; Isotopes; Lopinavir; Pandemics; Pyrazines; Pyrroles; Ritonavir; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2021 |
Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Substitution; Animals; COVID-19; COVID-19 Drug Treatment; Drug Resistance, Viral; Evolution, Molecular; Genetic Variation; Humans; Mink; Models, Molecular; Protein Conformation; RNA, Viral; SARS-CoV-2; Sequence Analysis, DNA; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication; Whole Genome Sequencing | 2021 |
Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Anticoagulants; COVID-19; COVID-19 Serotherapy; Critical Care; Dexamethasone; Disease Management; Evidence-Based Medicine; Hemodynamics; Humans; Hydroxychloroquine; Immunization, Passive; Intensive Care Units; Patient Positioning; Practice Guidelines as Topic; Ventilation | 2021 |
Comparison of Antiviral Activity of Gemcitabine with 2'-Fluoro-2'-Deoxycytidine and Combination Therapy with Remdesivir against SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Deoxycytidine; Drug Therapy, Combination; Gemcitabine; Humans; Inhibitory Concentration 50; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
Reply to Yan and Muller, "Remdesivir for COVID-19: Why Not Dose Higher?"
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Remdesivir for COVID-19: Why Not Dose Higher?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 2).
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pneumonia, Viral; SARS-CoV-2 | 2021 |
The
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Cattle; Cell Line; Cells, Cultured; Coronavirus; Drug Delivery Systems; Drug Synergism; Heparan Sulfate Proteoglycans; Heparin; Humans; Lactoferrin; Microbial Sensitivity Tests; SARS-CoV-2; Virus Attachment | 2021 |
Comment on: Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Intensive Care Units; Italy; Respiration, Artificial; SARS-CoV-2 | 2021 |
Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Culture Techniques; Cell Line; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Defensins; Guanidines; Humans; Peptidomimetics; Pyrimidines; SARS-CoV-2; Vero Cells; Virus Internalization; Virus Replication | 2021 |
Remdesivir-Associated Pancreatitis.
Topics: Acute Disease; Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Pancreatitis | 2022 |
Potential remdesivir-related transient bradycardia in patients with coronavirus disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Aged; Alanine; Bradycardia; COVID-19; COVID-19 Drug Treatment; Female; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; SARS-CoV-2; Treatment Outcome | 2021 |
Remdesivir for the Treatment of COVID-19: A Need for Combined
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Catalytic Domain; Humans; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Viral Proteins; Virus Replication | 2021 |
Clinical features and outcomes of hospitalized COVID-19 patients in a low burden region.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Adult; Aged; Alanine; Anti-Bacterial Agents; Antimalarials; Antiviral Agents; Azithromycin; Colchicine; COVID-19; Drug Therapy, Combination; Female; Greece; Hospitalization; Humans; Hydroxychloroquine; Male; Middle Aged; Retrospective Studies; SARS-CoV-2; Treatment Outcome; Young Adult | 2021 |
Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Carbonates; Cathepsin L; Cell Line; Chlorocebus aethiops; Coronavirus 229E, Human; Coronavirus 3C Proteases; Coronavirus NL63, Human; Coronavirus OC43, Human; COVID-19 Drug Treatment; Drug Combinations; Glycoproteins; HEK293 Cells; Humans; Leucine; Middle East Respiratory Syndrome Coronavirus; Oligopeptides; Proline; SARS-CoV-2; Serine Endopeptidases; Sulfonic Acids; Vero Cells | 2021 |
Kidney disorders as serious adverse drug reactions of remdesivir in coronavirus disease 2019: a retrospective case-noncase study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug-Related Side Effects and Adverse Reactions; Humans; Kidney; Retrospective Studies; SARS-CoV-2 | 2021 |
A shorter symptom onset to remdesivir treatment (SORT) interval is associated with a lower mortality in moderate-to-severe COVID-19: A real-world analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Hospital Mortality; Humans; Male; Middle Aged; Odds Ratio; Retrospective Studies; Treatment Outcome | 2021 |
Baricitinib Therapy in Covid-19 Pneumonia - An Unmet Need Fulfilled.
Topics: Adenosine Monophosphate; Adult; Alanine; Azetidines; COVID-19 Drug Treatment; Humans; Purines; Pyrazoles; SARS-CoV-2; Sulfonamides | 2021 |
In vitro activity of itraconazole against SARS-CoV-2.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Repositioning; Furans; Humans; Itraconazole; Pyrroles; SARS-CoV-2; Triazines; Vero Cells; Virus Replication | 2021 |
COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels.
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antimalarials; Antiviral Agents; Azithromycin; Chloroquine; COVID-19; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; ERG1 Potassium Channel; HEK293 Cells; Humans; Hydroxychloroquine; Potassium Channel Blockers | 2021 |
Real-life use of remdesivir in hospitalized patients with COVID-19.
Topics: Adenosine Monophosphate; Aged; Alanine; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antiviral Agents; Cohort Studies; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Female; Hospital Mortality; Humans; Inpatients; Intensive Care Units; Male; Middle Aged; Respiration, Artificial; Spain; Treatment Outcome | 2021 |
Dermatological manifestations during COVID-19 infection: a case series and discussion on the problem of differential diagnosis.
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; SARS-CoV-2; Skin Diseases | 2021 |
[Scientific research in times of pandemics.]
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Vaccines; Disease Outbreaks; Drug Approval; European Union; Humans; Influenza, Human; Information Dissemination; Informed Consent; Oseltamivir; Pandemics; Peer Review, Research; Periodicals as Topic; Politics; Publishing; Research; Risk; SARS-CoV-2; Time Factors; United States | 2021 |
1'-Ribose cyano substitution allows Remdesivir to effectively inhibit nucleotide addition and proofreading during SARS-CoV-2 viral RNA replication.
Topics: Adenosine Monophosphate; Alanine; Catalytic Domain; COVID-19; COVID-19 Drug Treatment; Cyanides; Humans; Molecular Dynamics Simulation; Nucleotides; Ribose; RNA-Dependent RNA Polymerase; SARS-CoV-2; Static Electricity; Virus Replication | 2021 |
A real-life setting evaluation of the effect of remdesivir on viral load in COVID-19 patients admitted to a large tertiary centre in Israel.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; Female; Hospitalization; Humans; Israel; Male; Middle Aged; Nasopharynx; SARS-CoV-2; Severity of Illness Index; Tertiary Healthcare; Treatment Outcome; Viral Load | 2021 |
Extensive environmental contamination and prolonged severe acute respiratory coronavirus-2 (SARS CoV-2) viability in immunosuppressed recent heart transplant recipients with clinical and virologic benefit with remdesivir.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Heart Transplantation; Humans; Severe Acute Respiratory Syndrome | 2022 |
Usage experience of remdesivir for SARS-CoV-2 infection in a patient with chronic cirrhosis of Child-Pugh class C.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Liver Cirrhosis | 2021 |
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Anti-Inflammatory Agents; Antiviral Agents; Biological Availability; Cell Fusion; Cell Line; Clofazimine; Coronavirus; Cricetinae; DNA Helicases; Drug Synergism; Female; Humans; Life Cycle Stages; Male; Mesocricetus; Pre-Exposure Prophylaxis; SARS-CoV-2; Species Specificity; Spike Glycoprotein, Coronavirus; Transcription, Genetic | 2021 |
Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents | 2021 |
Prolonged SARS-CoV-2 viral shedding in patients with solid tumours and associated factors.
Topics: Adenosine Monophosphate; Aged; Alanine; Antineoplastic Agents; Antiviral Agents; Breast Neoplasms; COVID-19; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing; COVID-19 Serotherapy; Dexamethasone; Drug Combinations; Female; Follow-Up Studies; Glucocorticoids; Humans; Hydroxychloroquine; Immunization, Passive; Immunotherapy; Latent Infection; Lopinavir; Lung Neoplasms; Male; Molecular Targeted Therapy; Neoplasms; Proportional Hazards Models; Risk Factors; Ritonavir; SARS-CoV-2; Spain; Time Factors; Virus Shedding | 2021 |
Prioritizing antiviral drugs against SARS-CoV-2 by integrating viral complete genome sequences and drug chemical structures.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Aniline Compounds; Antiviral Agents; Drug Evaluation, Preclinical; Genome, Viral; Molecular Docking Simulation; Ribavirin; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Sulfonamides | 2021 |
Remdesivir: An Antiviral Still Seeking a Raison d'Être.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Humans | 2021 |
Clinical and Virologic Effectiveness of Remdesivir Treatment for Severe Coronavirus Disease 2019 (COVID-19) in Korea: a Nationwide Multicenter Retrospective Cohort Study.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Female; Humans; Male; Middle Aged; Real-Time Polymerase Chain Reaction; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Viral Load | 2021 |
Early combination treatment with existing HIV antivirals: an effective treatment for COVID-19?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Atazanavir Sulfate; COVID-19 Drug Treatment; Darunavir; Drug Combinations; Drug Therapy, Combination; Early Medical Intervention; Emtricitabine; Humans; Lamivudine; Lopinavir; Molecular Docking Simulation; Nucleosides; Protease Inhibitors; Ritonavir; SARS-CoV-2 | 2021 |
Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, High Pressure Liquid; COVID-19 Drug Treatment; Drug Monitoring; Female; Humans; Limit of Detection; Male; Tandem Mass Spectrometry | 2021 |
Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Baltimore; Case-Control Studies; Comparative Effectiveness Research; COVID-19; COVID-19 Drug Treatment; District of Columbia; Female; Hospital Mortality; Hospitalization; Humans; Male; Middle Aged; Retrospective Studies; SARS-CoV-2; Treatment Outcome | 2021 |
A young man presenting with encephalopathy and seizures secondary to SARS-CoV-2.
Topics: Adenosine Monophosphate; Adult; Alanine; Anticonvulsants; Antiviral Agents; Brain Diseases; Confusion; COVID-19; COVID-19 Serotherapy; Humans; Immunization, Passive; Magnetic Resonance Imaging; Male; Polymerase Chain Reaction; Radiography; SARS-CoV-2; Seizures; Treatment Outcome | 2021 |
In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Pyrazines; Pyrrolidines; Ribavirin; RNA, Viral; SARS-CoV-2 | 2022 |
Combination therapy protects macaques against advanced Marburg virus disease.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Monoclonal; Antibodies, Viral; Disease Models, Animal; Drug Therapy, Combination; Macaca mulatta; Marburg Virus Disease; Marburgvirus; Viral Load | 2021 |
Remdesivir for the treatment of COVID-19 in pregnancy.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Young Adult | 2021 |
Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU-authors' response.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Intensive Care Units; Italy; Respiration, Artificial; SARS-CoV-2 | 2021 |
Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Antiviral Agents; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Dynamics Simulation; SARS-CoV-2; Thermodynamics; Viral Nonstructural Proteins | 2021 |
COVID-19 and Heart Transplant: A Case Series and Review of the Literature.
Topics: Adenosine Monophosphate; Aged; Alanine; Comorbidity; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Glucocorticoids; Graft Rejection; Heart Failure; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; SARS-CoV-2; Withholding Treatment | 2021 |
COVID-19, a tale of two peaks: patients' characteristics, treatments, and clinical outcomes.
Topics: Adenosine Monophosphate; Adult; Age Distribution; Aged; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Disease Progression; Female; Hospitalization; Humans; Immunization, Passive; Male; Middle Aged; Respiration, Artificial; Retrospective Studies; Sex Distribution | 2021 |
Prolonged persistence of SARS-CoV-2 infection during A+AVD therapy for classical Hodgkin's lymphoma: A case report.
Topics: Adenosine Monophosphate; Adult; Alanine; Amides; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Brentuximab Vedotin; COVID-19; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; Dacarbazine; Disease Progression; Doxorubicin; Hodgkin Disease; Humans; Male; Pregnenediones; Pyrazines; Time Factors; Vinblastine | 2021 |
The Role of Immunological and Clinical Biomarkers to Predict Clinical COVID-19 Severity and Response to Therapy-A Prospective Longitudinal Study.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Bacteremia; Biomarkers; C-Reactive Protein; Cohort Studies; Comorbidity; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Female; Humans; Interleukin-6; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Respiratory Distress Syndrome; Severity of Illness Index; Staphylococcal Infections | 2021 |
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chemical and Drug Induced Liver Injury; COVID-19; COVID-19 Drug Treatment; Critical Care; Drug Hypersensitivity; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Fluoxetine; Hepatitis C, Chronic; Humans; Itraconazole; Pharmaceutical Preparations; SARS-CoV-2 | 2021 |
Use of Remdesivir in Myasthenia gravis and COVID-19.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Fatal Outcome; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Treatment Outcome | 2021 |
Neonates With SARS-CoV-2 Infection and Pulmonary Disease Safely Treated With Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Infant; Male; SARS-CoV-2; United Kingdom | 2021 |
The race for antiviral drugs to beat COVID - and the next pandemic.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Birds; Clinical Trials as Topic; Coronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cytidine; Drug Development; Drug Industry; Europe; Humans; Hydroxylamines; Indoles; Influenza, Human; Leucine; Orthomyxoviridae; Pandemics; Pyrrolidinones; Severe Acute Respiratory Syndrome; Strategic Stockpile; United States | 2021 |
Funders, now is the time to invest big in COVID drugs.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Development; Humans; Investments; Pandemics; Strategic Stockpile | 2021 |
Economic evaluation of remdesivir for the treatment of severe COVID-19 patients in China under different scenarios.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; China; Cost-Benefit Analysis; COVID-19; COVID-19 Drug Treatment; Humans; Quality of Life | 2021 |
A combined assay for quantifying remdesivir and its metabolite, along with dexamethasone, in serum.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, Liquid; COVID-19 Drug Treatment; Dexamethasone; Furans; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2021 |
Machine Learning as a Precision-Medicine Approach to Prescribing COVID-19 Pharmacotherapy with Remdesivir or Corticosteroids.
Topics: Adenosine Monophosphate; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Female; Humans; Machine Learning; Male; Middle Aged; Young Adult | 2021 |
Laboratory divergences in concurrent diagnosis of acute myeloid leukemia relapse and COVID-19: A case report.
Topics: Adenosine Monophosphate; Alanine; Allografts; Antiviral Agents; Bone Marrow; Chromosomes, Human, Pair 8; COVID-19; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; Hematopoietic Stem Cell Transplantation; Humans; Laboratories; Leukemia, Myeloid, Acute; Lymphocytes; Male; Middle Aged; Neoplastic Stem Cells; Plasma Cells; Recurrence; Salvage Therapy; SARS-CoV-2; Trisomy | 2021 |
Japan's Drug Regulation During the COVID-19 Pandemic: Lessons From a Case Study of Favipiravir.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Clinical Trials, Phase III as Topic; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Double-Blind Method; Drug Approval; Humans; Japan; Pyrazines | 2022 |
Compassionate Use of Remdesivir in Children With Severe COVID-19.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Child; Child, Preschool; Compassionate Use Trials; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Female; Hospitalization; Humans; Infant; Male; Oxygen Inhalation Therapy; Respiration, Artificial; SARS-CoV-2; Severity of Illness Index; Treatment Outcome | 2021 |
Remdesivir: Preliminary Data and Clinical Use Versus Recommended Use.
Topics: Adenosine Monophosphate; Alanine; Humans; Preliminary Data | 2021 |
A 10-Year-old Girl With Late Acute Lymphoblastic Leukemia Recurrence Diagnosed With COVID-19 and Treated With Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Child; COVID-19; COVID-19 Drug Treatment; Female; Humans; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; SARS-CoV-2 | 2022 |
Successful Management of COVID-19 Infection in 2 Early Post-Liver Transplant Recipients.
Topics: Adenosine Monophosphate; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Female; Humans; Hydroxychloroquine; Immunization, Passive; Immunosuppressive Agents; Liver Failure; Liver Transplantation; Methylprednisolone; Middle Aged; SARS-CoV-2 | 2021 |
A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase.
Topics: A549 Cells; Adenosine Monophosphate; Alanine; Antiviral Agents; Cell Survival; COVID-19; COVID-19 Drug Treatment; Drug Discovery; Exoribonucleases; HEK293 Cells; High-Throughput Screening Assays; Humans; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Viral Nonstructural Proteins | 2021 |
Bradycardia associated with remdesivir therapy for COVID-19 in a 59-year-old man.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bradycardia; COVID-19 Drug Treatment; Humans; Male; Middle Aged | 2021 |
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Alveolar Epithelial Cells; Child, Preschool; COVID-19; COVID-19 Drug Treatment; Drug Discovery; Epithelial Cells; Epithelium; Female; Fibroblasts; Humans; Lung; Male; Middle Aged; Models, Biological; Primary Cell Culture; Respiratory Mucosa; SARS-CoV-2; Virus Replication | 2021 |
Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; beta-Cyclodextrins; Calorimetry, Differential Scanning; COVID-19 Drug Treatment; Excipients; Freeze Drying; Magnetic Resonance Spectroscopy; Microscopy, Electron, Scanning; Molecular Docking Simulation; Nanofibers; Powders; Solubility; Spectrum Analysis, Raman; X-Ray Diffraction | 2021 |
Treatment patterns in US patients hospitalized with COVID-19 and pulmonary involvement.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Black People; Bronchodilator Agents; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Female; Hospitalization; Humans; Hydroxychloroquine; Lung; Male; Middle Aged; Pneumonia; Retrospective Studies; SARS-CoV-2; United States; White People | 2021 |
Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; Aspirin; Blood Platelets; Coronary Artery Disease; COVID-19; COVID-19 Drug Treatment; Diabetes Mellitus; Disseminated Intravascular Coagulation; Drug Combinations; Female; Hospital Mortality; Humans; Hypertension; Iran; Lopinavir; Lung; Male; Middle Aged; Platelet Aggregation Inhibitors; Pulmonary Embolism; Respiration, Artificial; Retrospective Studies; Ritonavir; SARS-CoV-2; Severity of Illness Index; Survival Analysis; Treatment Outcome | 2021 |
Feasibility and safety of remdesivir in SARS-CoV2 infected renal transplant recipients: A retrospective cohort from a developing nation.
Topics: Adenosine Monophosphate; Adult; Alanine; COVID-19 Drug Treatment; Developing Countries; Feasibility Studies; Humans; Kidney Transplantation; Middle Aged; Retrospective Studies; RNA, Viral; SARS-CoV-2; Transplant Recipients | 2021 |
Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; Coronavirus Nucleocapsid Proteins; COVID-19; Deep Learning; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Machine Learning; Phosphoproteins; SARS-CoV-2; Vero Cells; Viral Load | 2021 |
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus Infections; COVID-19 Drug Treatment; Drug Approval; Drug Evaluation, Preclinical; Drug Repositioning; Drug Synergism; Humans; Life Cycle Stages; Middle East Respiratory Syndrome Coronavirus; SARS-CoV-2; Small Molecule Libraries | 2021 |
Remdesivir Use in COVID-19 Patients: Cutaneous Adverse Effect or Disease Manifestation?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; Diagnosis, Differential; Drug Eruptions; Humans | 2021 |
Clinical Outcomes of COVID-19 Patients Treated with Convalescent Plasma or Remdesivir Alone and in Combination at a Community Hospital in California's Central Valley.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; California; Combined Modality Therapy; COVID-19; COVID-19 Serotherapy; Female; Hospitals, Community; Humans; Immunization, Passive; Length of Stay; Male; Middle Aged; Retrospective Studies; Treatment Outcome | 2021 |
Hepatobiliary Adverse Drug Reactions Associated With Remdesivir: The WHO International Pharmacovigilance Study.
Topics: Adenosine Monophosphate; Adverse Drug Reaction Reporting Systems; Alanine; COVID-19 Drug Treatment; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacovigilance; SARS-CoV-2; World Health Organization | 2021 |
A toddler diagnosed with severe postinfectious bronchiolitis obliterans and COVID-19 infection.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Bronchiolitis Obliterans; Child; Child, Preschool; COVID-19; Humans; Pandemics; Retrospective Studies; SARS-CoV-2 | 2021 |
Remdesivir and Ledipasvir among the FDA-Approved Antiviral Drugs Have Potential to Inhibit SARS-CoV-2 Replication.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Benzimidazoles; Chlorocebus aethiops; Fluorenes; Molecular Docking Simulation; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
A Novel Liquid Chromatographic Method for the Quantitative Determination of Degradation Products in Remdesivir Injectable Drug product.
Topics: Adenosine Monophosphate; Alanine; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Pharmaceutical Preparations; Reproducibility of Results | 2022 |
Peripheral infiltration of remdesivir in 3 patients with COVID-19: Case series and discussion.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Female; Humans; Male; SARS-CoV-2 | 2021 |
A case report of COVID-19 in refractory myasthenia: Outcome with remdesivir and dexamethasone.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Dexamethasone; Drug Therapy, Combination; Glucocorticoids; Humans; Male; Myasthenia Gravis; Plasmapheresis; Pneumonia, Viral; SARS-CoV-2 | 2021 |
Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells.
Topics: Adenosine; Adenosine Monophosphate; Alanine; CD8-Positive T-Lymphocytes; Cell Proliferation; Humans; Immunologic Memory; T-Lymphocytes | 2021 |
Predictors of mortality in patients with severe COVID-19 pneumonia - a retrospective study.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; COVID-19; Critical Illness; Female; Hospital Mortality; Hospitalization; Humans; India; Intensive Care Units; Male; Middle Aged; Retrospective Studies; Risk Factors; Treatment Outcome | 2021 |
Realizing Public Rights Through Government Patent Use.
Topics: Adenosine Monophosphate; Alanine; Biomedical Research; Drug Development; Drugs, Generic; Financing, Government; Patents as Topic; Public Sector | 2021 |
Synthesis, molecular docking, and in silico ADMET studies of 4-benzyl-1-(2,4,6-trimethyl-benzyl)-piperidine: Potential Inhibitor of SARS-CoV2.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Binding Sites; COVID-19; Crystallography, X-Ray; Density Functional Theory; Half-Life; Humans; Molecular Conformation; Molecular Docking Simulation; Piperidines; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Viral Matrix Proteins | 2021 |
Plasma concentrations of remdesivir metabolite in a critical COVID-19 patient needing continuous venovenous haemodialysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Continuous Renal Replacement Therapy; COVID-19 Drug Treatment; Female; Humans; Middle Aged | 2021 |
Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment
Topics: A549 Cells; Adenosine Monophosphate; Administration, Inhalation; Aerosols; Alanine; COVID-19 Drug Treatment; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Humans; Liposomes; Nanoparticles; Particle Size | 2021 |
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Treatment Outcome | 2021 |
Notes From the Field: The Combined Effects of Tocilizumab and Remdesivir in a Patient With Severe COVID-19 and Cytokine Release Syndrome.
Topics: Adenosine Monophosphate; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Cytokine Release Syndrome; Drug Therapy, Combination; Humans; Immunization, Passive; Male; SARS-CoV-2 | 2021 |
Green and sensitive spectrofluorimetric determination of Remdesivir, an FDA approved SARS-CoV-2 candidate antiviral; application in pharmaceutical dosage forms and spiked human plasma.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pharmaceutical Preparations; SARS-CoV-2; Spectrometry, Fluorescence | 2021 |
Medication Use Patterns in Hospitalized Patients With COVID-19 in California During the Pandemic.
Topics: Adenosine Monophosphate; Adult; Alanine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anticoagulants; Antiviral Agents; Azithromycin; California; Colchicine; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Drug Therapy, Combination; Drug Utilization Review; Female; Hospitalization; Humans; Hydrocortisone; Hydroxychloroquine; Male; Pandemics; SARS-CoV-2 | 2021 |
A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Combined Modality Therapy; Computational Biology; COVID-19 Drug Treatment; Drug Repositioning; Drug Synergism; Drug Therapy, Combination; GTP Phosphohydrolases; Humans; Knowledge Bases; Nelfinavir; Pandemics; Raloxifene Hydrochloride; SARS-CoV-2 | 2021 |
Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Dogs; Dose-Response Relationship, Drug; Drug Approval; Furans; Humans; Kidney; Kidney Tubules, Proximal; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Pyrroles; Triazines | 2021 |
Bradycardia due to remdesivir: Report of two cases.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bradycardia; Humans | 2022 |
Remdesivir treatment and transient bradycardia in patients with coronavirus diseases 2019 (COVID-19).
Topics: Adenosine Monophosphate; Alanine; Bradycardia; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Remdesivir for Early COVID-19 Treatment of High-Risk Individuals Prior to or at Early Disease Onset-Lessons Learned.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome; Virus Replication | 2021 |
Medication of Hydroxychloroquine, Remdesivir and Convalescent Plasma during the COVID-19 Pandemic in Germany-An Ethical Analysis.
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Ethical Analysis; Germany; Humans; Hydroxychloroquine; Immunization, Passive; Pandemics; SARS-CoV-2 | 2021 |
Assessing efficacy of antiviral therapy for COVID-19 patients: A case study on remdesivir with bayesian synthesis design and multistate analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bayes Theorem; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
Remdesivir in moderate to severe COVID-19: A matter of time?
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Culture Techniques; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Folic Acid Antagonists; Humans; Methotrexate; RNA, Viral; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Alanine; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Disease Models, Animal; Humans; Immunomodulation; Inflammasomes; Inflammation Mediators; Macrophages, Peritoneal; Male; Mice; Mitogen-Activated Protein Kinases; Models, Biological; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction | 2021 |
Immune responses and therapeutic challenges in paediatric patients with new-onset acute myeloid leukaemia and concomitant COVID-19.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antimalarials; Antineoplastic Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Disease Management; Humans; Hydroxychloroquine; Hydroxyurea; Leukemia, Myeloid, Acute; Male; SARS-CoV-2; Young Adult | 2021 |
Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; COVID-19 Drug Treatment; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Protease Inhibitors; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Vero Cells; Viral Protease Inhibitors | 2021 |
Real-world risk evaluation of remdesivir in patients with an estimated glomerular filtration rate of less than 30 mL/min.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Glomerular Filtration Rate; Humans | 2021 |
Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Computer Simulation; COVID-19; COVID-19 Drug Treatment; Databases, Chemical; Drug Interactions; Furans; Humans; Prodrugs; Pyrroles; Risk Assessment; Risk Factors; SARS-CoV-2; Triazines | 2021 |
Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Base Pairing; Coronavirus RNA-Dependent RNA Polymerase; Ebolavirus; Enzyme Inhibitors; Models, Molecular; Protein Biosynthesis; RNA; RNA, Messenger; RNA, Viral; SARS-CoV-2; Virus Replication | 2021 |
Improved Survival Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Treated With Remdesivir and Dexamethasone. A Nationwide Population-Based Cohort Study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cohort Studies; COVID-19 Drug Treatment; Dexamethasone; Humans; Retrospective Studies; SARS-CoV-2 | 2021 |
Remdesivir, Renal Function and Short-Term Clinical Outcomes in Elderly COVID-19 Pneumonia Patients: A Single-Centre Study.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Aging; Alanine; Antiviral Agents; Cohort Studies; COVID-19; COVID-19 Drug Treatment; Female; Glomerular Filtration Rate; Humans; Male; Retrospective Studies; SARS-CoV-2; Severity of Illness Index; Treatment Outcome | 2021 |
COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Alanine; Antibodies, Monoclonal, Humanized; Anticoagulants; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Delivery of Health Care; Drug Therapy, Combination; Humans; Hydroxychloroquine; Intensive Care Units; Length of Stay; Male; Middle Aged; Pandemics; Retrospective Studies; SARS-CoV-2; Treatment Outcome; United States | 2021 |
Impact of Remdesivir on the Treatment of COVID-19 During the First Wave in Spain.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Europe; Humans; Retrospective Studies; SARS-CoV-2; Spain | 2021 |
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Lung; Nerve Tissue Proteins; SARS-CoV-2 | 2021 |
Remdesivir inhibits the polymerases of the novel filoviruses Lloviu and Bombali virus.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cell Line; Ebolavirus; Filoviridae; Humans; Inhibitory Concentration 50; Phylogeny; RNA-Dependent RNA Polymerase; Virus Replication | 2021 |
Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors.
Topics: Acetamides; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Molecular Structure; Protein Binding; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Structure-Activity Relationship | 2021 |
Acute Pain Crisis Caused by Tramadol Remdesivir Drug-Drug Interaction.
Topics: Acute Pain; Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Drug Interactions; Humans; Pharmaceutical Preparations; SARS-CoV-2; Tramadol; United States | 2021 |
Novel adenosine derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Binding Sites; Computer Simulation; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Drug Design; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; SARS-CoV-2 | 2021 |
COVID-19 Second Wave in India - Wait or Act?
Topics: Adenosine Monophosphate; Administration, Intravenous; Alanine; Ambulatory Care; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Critical Pathways; Female; Humans; India; Male; Middle Aged; Risk Adjustment; SARS-CoV-2; Severity of Illness Index; Triage | 2021 |
Remdesivir-Induced Bradycardia in COVID-19: A Single Center Prospective Study.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Bradycardia; COVID-19; COVID-19 Drug Treatment; Female; Heart Rate; Hospitalization; Humans; Incidence; Italy; Male; Middle Aged; Prospective Studies; Risk Assessment; Risk Factors | 2021 |
To Study Role of Remdesivir in COVID 19 Patients at a Tertiary Referral Hospital in Mumbai, India.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; India; SARS-CoV-2; Tertiary Care Centers | 2021 |
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease.
Topics: Adenosine Monophosphate; Alanine; Aniline Compounds; Animals; Antiviral Agents; Benzamides; Chlorocebus aethiops; Coronavirus Papain-Like Proteases; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Assays; Flavins; Fluorescence Resonance Energy Transfer; Furans; High-Throughput Screening Assays; Inhibitory Concentration 50; Naphthalenes; Phenanthrenes; Quinones; Reproducibility of Results; SARS-CoV-2; Small Molecule Libraries; Vero Cells; Virus Replication | 2021 |
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorobenzenes; Chlorocebus aethiops; Drug Evaluation, Preclinical; Enzyme Assays; Exoribonucleases; Fluorescence Resonance Energy Transfer; High-Throughput Screening Assays; Indazoles; Indenes; Indoles; Methyltransferases; Nitriles; Phenothiazines; Purines; Reproducibility of Results; RNA Caps; SARS-CoV-2; Small Molecule Libraries; Substrate Specificity; Trifluperidol; Vero Cells; Viral Nonstructural Proteins; Viral Regulatory and Accessory Proteins | 2021 |
Modeling within-Host SARS-CoV-2 Infection Dynamics and Potential Treatments.
Topics: Adaptive Immunity; Adenosine Monophosphate; Alanine; Antibodies, Viral; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Host-Pathogen Interactions; Humans; Immunity, Innate; Immunization, Passive; Models, Theoretical; Virus Internalization | 2021 |
Remdesivir MD Simulations Suggest a More Favourable Binding to SARS-CoV-2 RNA Dependent RNA Polymerase Mutant P323L Than Wild-Type.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Binding Sites; Catalytic Domain; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Dynamics Simulation; Point Mutation; SARS-CoV-2 | 2021 |
Dramatic Response to Convalescent Hyperimmune Plasma in Association With an Extended Course of Remdesivir in 4 B Cell-Depleted Non-Hodgkin Lymphoma Patients With SARS-Cov-2 Pneumonia After Rituximab Therapy.
Topics: Adenosine Monophosphate; Alanine; B-Lymphocytes; Combined Modality Therapy; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Administration Schedule; Humans; Immunization, Passive; Immunocompromised Host; Immunosuppressive Agents; Italy; Lymphoma, Non-Hodgkin; Lymphopenia; Male; Middle Aged; Pneumonia, Viral; Rituximab; SARS-CoV-2; Treatment Outcome | 2021 |
Accelerated stability study of the ester prodrug remdesivir: Recently FDA-approved Covid-19 antiviral using reversed-phase-HPLC with fluorimetric and diode array detection.
Topics: Acetonitriles; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; COVID-19 Drug Treatment; Drug Stability; Hot Temperature; Humans; Hydrolysis; Limit of Detection; Oxidation-Reduction; Photolysis; Prodrugs | 2021 |
Remdesivir might induce changes in electrocardiogram beyond bradycardia in patients with coronavirus disease 2019-The pilot study.
Topics: Adenosine Monophosphate; Alanine; Bradycardia; COVID-19 Drug Treatment; Electrocardiography; Humans; Pilot Projects; SARS-CoV-2 | 2021 |
Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; Drug Synergism; Humans; User-Computer Interface; Vero Cells | 2021 |
A fast protein binding site comparison algorithm for proteome-wide protein function prediction and drug repurposing.
Topics: Adenosine Monophosphate; Alanine; Algorithms; Antiviral Agents; Binding Sites; Coronavirus 3C Proteases; Databases, Protein; Drug Repositioning; GTP Phosphohydrolases; Phosphoglycerate Mutase; Proteins; ROC Curve; SARS-CoV-2 | 2021 |
Update Alert: Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 2).
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Physicians; SARS-CoV-2; United States | 2021 |
Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Hemorrhagic Fever, Ebola; Humans; Macaca mulatta; SARS-CoV-2; Treatment Outcome | 2021 |
Differential Cytokine Responses in Hospitalized COVID-19 Patients Limit Efficacy of Remdesivir.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antibodies, Viral; Antiviral Agents; Becaplermin; Brain-Derived Neurotrophic Factor; Case-Control Studies; COVID-19; COVID-19 Drug Treatment; Cytokines; Female; Hospitalization; Humans; Immunoglobulin G; Male; Membrane Proteins; Middle Aged; Prospective Studies; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Treatment Outcome | 2021 |
Association of Remdesivir Treatment With Survival and Length of Hospital Stay Among US Veterans Hospitalized With COVID-19.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Female; Hospital Mortality; Hospitalization; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Pandemics; Patient Discharge; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Severity of Illness Index; Survival Analysis; United States; Veterans; Veterans Health Services | 2021 |
Remdesivir Use and Hospital Length of Stay-The Paradox of a Clinical Trial vs Real-Life Use.
Topics: Adenosine Monophosphate; Alanine; Hospitals; Humans; Length of Stay | 2021 |
Clinical Improvement, Outcomes, Antiviral Activity, and Costs Associated With Early Treatment With Remdesivir for Patients With Coronavirus Disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Hospital Mortality; Humans; Immunoglobulin G; Retrospective Studies; SARS-CoV-2 | 2022 |
Clinical course and serial chest ultra-low-dose CT findings in a patient with COVID-19 treated with remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Female; Humans; Middle Aged; Radiation Dosage; Thorax; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
Remdesivir shifts circadian rhythmicity to eveningness; similar to the most prevalent chronotype in ADHD.
Topics: Adenosine Monophosphate; Alanine; Attention Deficit Disorder with Hyperactivity; Circadian Clocks; Circadian Rhythm; Humans; Sleep | 2021 |
Sinus Bradycardia in Children Treated With Remdesivir for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Bradycardia; Child; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2021 |
Rethinking remdesivir for COVID-19: A Bayesian reanalysis of trial findings.
Topics: Adenosine Monophosphate; Alanine; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; Europe; Humans; SARS-CoV-2; Treatment Outcome; United States | 2021 |
Pharmacokinetics of Remdesivir and GS-441524 during PIRRT and Seraph 100 Therapy.
Topics: Adenosine; Adenosine Monophosphate; Adult; Aged; Alanine; COVID-19 Drug Treatment; Female; Hemofiltration; Humans; Intermittent Renal Replacement Therapy; Male; SARS-CoV-2 | 2021 |
Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; COVID-19 Drug Treatment; Cricetinae; Humans; Lipids; Prodrugs; SARS-CoV-2 | 2021 |
A Case Report for Severe COVID-19 in a 9-Year-Old Child Treated with Remdesivir and Dexamethasone.
Topics: Adenosine Monophosphate; Alanine; Child; COVID-19 Drug Treatment; Dexamethasone; Drug Therapy, Combination; Humans; Male; SARS-CoV-2 | 2021 |
Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cells, Cultured; Chymases; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Humans; Molecular Docking Simulation; Phenylurea Compounds; Protein Kinase Inhibitors; Quinolines; SARS-CoV-2 | 2021 |
Remdesivir therapy associated with Bradycardia in SARS-CoV2.
Topics: Adenosine Monophosphate; Alanine; Bradycardia; COVID-19 Drug Treatment; Humans; RNA, Viral; SARS-CoV-2 | 2021 |
Trends in COVID-19 cases and clinical management in Veterans Health Administration medical facilities: A national cohort study.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Comorbidity; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Female; Hospital Mortality; Hospitalization; Humans; Longitudinal Studies; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Respiration, Artificial; Retrospective Studies; United States; Veterans Health | 2021 |
Assessment of adverse events associated with remdesivir use for coronavirus disease 2019 using real-world data.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Adverse Drug Reaction Reporting Systems; Alanine; Antiviral Agents; Bradycardia; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Function Tests; Male; Middle Aged; SARS-CoV-2; United States; United States Food and Drug Administration | 2021 |
Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia.
Topics: Adenosine Monophosphate; Adult; Agammaglobulinemia; Alanine; Antibodies, Neutralizing; Antibodies, Viral; COVID-19 Drug Treatment; Genetic Diseases, X-Linked; Humans; Recurrence; SARS-CoV-2 | 2021 |
Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Lung; Macaca mulatta; Models, Theoretical; Nose; Pharynx; SARS-CoV-2; Time Factors; Viral Load; Virus Replication; Virus Shedding | 2021 |
Therapeutic interventions of remdesivir in diabetic and nondiabetic COVID-19 patients: A prospective observational study conducted on Pakistani population.
Topics: Adenosine Monophosphate; Adolescent; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Diabetes Mellitus; Female; Hospitalization; Humans; Male; Middle Aged; Pakistan; Prospective Studies; Young Adult | 2021 |
Structural Bioinformatics Used to Predict the Protein Targets of Remdesivir and Flavones in SARS-CoV-2 Infection.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Computational Biology; COVID-19 Drug Treatment; Flavones; Humans; SARS-CoV-2 | 2022 |
The association of remdesivir and in-hospital outcomes for COVID-19 patients treated with steroids.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Retrospective Studies; SARS-CoV-2; Steroids | 2021 |
Clinical Trends Among U.S. Adults Hospitalized With COVID-19, March to December 2020 : A Cross-Sectional Study.
Topics: Adenosine Monophosphate; Adolescent; Adrenal Cortex Hormones; Adult; Age Distribution; Aged; Alanine; Antiviral Agents; COVID-19; Critical Care; Cross-Sectional Studies; Female; Hospitalization; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Pandemics; Respiration, Artificial; SARS-CoV-2; United States; Vasoconstrictor Agents; Young Adult | 2021 |
Reply to Yan and Muller, "Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver".
Topics: Adenosine Monophosphate; Alanine; Liver; Sequence Analysis, RNA | 2021 |
Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Liver; Sequence Analysis, RNA | 2021 |
Remdesivir in the COVID-19 Pandemic: An Analysis of Spontaneous Reports in VigiBase During 2020.
Topics: Adenosine Monophosphate; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Child; Child, Preschool; COVID-19 Drug Treatment; Female; Humans; Male; Middle Aged; Pandemics; SARS-CoV-2; Severity of Illness Index; Sex Factors; Socioeconomic Factors; World Health Organization; Young Adult | 2021 |
Cost-Effectiveness Analysis of Remdesivir Treatment in COVID-19 Patients Requiring Low-Flow Oxygen Therapy: Payer Perspective in Turkey.
Topics: Adenosine Monophosphate; Alanine; Cost-Benefit Analysis; COVID-19 Drug Treatment; Humans; Oxygen; SARS-CoV-2; Turkey | 2021 |
Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Humans; Respiration, Artificial; SARS-CoV-2 | 2022 |
Cardiovascular Considerations of Remdesivir and Favipiravir in the Treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Heart Diseases; Humans; Pyrazines; SARS-CoV-2 | 2021 |
Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caspase 9; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Cytopathogenic Effect, Viral; Endoplasmic Reticulum Stress; Humans; MAP Kinase Signaling System; Models, Biological; Nelfinavir; NF-kappa B; SARS-CoV-2; Unfolded Protein Response; Vero Cells | 2022 |
Novel quinolone derivatives targeting human dihydroorotate dehydrogenase suppress Ebola virus infection in vitro.
Topics: Adenosine Monophosphate; Africa, Western; Alanine; Antiviral Agents; Cell Line; Dihydroorotate Dehydrogenase; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Inhibitory Concentration 50; Quinolones; Virus Replication | 2021 |
Combination Treatment With Remdesivir and Ivermectin Exerts Highly Synergistic and Potent Antiviral Activity Against Murine Coronavirus Infection.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus Infections; COVID-19 Drug Treatment; Humans; Ivermectin; Mice; Murine hepatitis virus; Pandemics; SARS-CoV-2 | 2021 |
Use of Hydroxychloroquine, Remdesivir, and Dexamethasone Among Adults Hospitalized With COVID-19 in the United States : A Retrospective Cohort Study.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Alanine; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Female; Humans; Hydroxychloroquine; Male; Middle Aged; Pandemics; Practice Patterns, Physicians'; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; United States; Young Adult | 2021 |
A cost of illness study of COVID-19 patients and retrospective modelling of potential cost savings when administering remdesivir during the pandemic "first wave" in a German tertiary care hospital.
Topics: Adenosine Monophosphate; Alanine; Cost of Illness; Cost Savings; COVID-19 Drug Treatment; Humans; Pandemics; Retrospective Studies; SARS-CoV-2; Tertiary Care Centers | 2022 |
Elevated inflammatory markers are associated with poor outcomes in COVID-19 patients treated with remdesivir.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Biomarkers; C-Reactive Protein; COVID-19; COVID-19 Drug Treatment; Female; Fibrin Fibrinogen Degradation Products; Humans; Inflammation; L-Lactate Dehydrogenase; Length of Stay; Male; Middle Aged; Prognosis; Retrospective Studies; SARS-CoV-2 | 2022 |
Remdesivir and Mortality in Patients With Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Oxygen; Retrospective Studies; SARS-CoV-2 | 2022 |
Pre-Hospital Administration of Remdesivir During a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Outbreak in a Skilled Nursing Facility.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Disease Outbreaks; Hospital Administration; Humans; SARS-CoV-2; Skilled Nursing Facilities | 2022 |
Clinical impact of combination therapy with baricitinib, remdesivir, and dexamethasone in patients with severe COVID-19.
Topics: Adenosine Monophosphate; Aged; Alanine; Azetidines; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Purines; Pyrazoles; Respiration, Artificial; SARS-CoV-2; Sulfonamides; Treatment Outcome | 2021 |
Evolution of viral variants in remdesivir-treated and untreated SARS-CoV-2-infected pediatrics patients.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Child; Child, Preschool; COVID-19; COVID-19 Drug Treatment; Drug Resistance, Viral; Evolution, Molecular; Female; Haplotypes; Humans; Infant; Lung; Male; Phylogeny; RNA, Viral; SARS-CoV-2; Viral Load; Virus Replication | 2022 |
Retrospective evaluation of seven different treatment protocols in hospitalized COVID-19 patients
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Amides; Antiviral Agents; Clinical Protocols; COVID-19; COVID-19 Nucleic Acid Testing; Female; Humans; Hydroxychloroquine; Length of Stay; Male; Middle Aged; Oseltamivir; Pandemics; Pyrazines; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Treatment Outcome; Young Adult | 2021 |
Optimal Timing of Remdesivir Initiation in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Administered With Dexamethasone.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Dexamethasone; Hospital Mortality; Humans; Immunoglobulin G; SARS-CoV-2 | 2022 |
Management and Outcome of Coronavirus Disease 2019 (COVID-19) in Pediatric Cancer Patients: A Single Centre Experience from a Developing Country.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Child; Child, Preschool; COVID-19; Developing Countries; Female; Humans; Infant; Male; Neoplasms; Prospective Studies; SARS-CoV-2; Severity of Illness Index; Treatment Outcome | 2021 |
Binding of boswellic acids to functional proteins of the SARS-CoV-2 virus: Bioinformatic studies.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Binding Sites; Boswellia; Computational Biology; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Nucleoproteins; Polyproteins; Prodrugs; Protein Binding; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Structure-Activity Relationship; Triterpenes; Viral Proteins | 2021 |
Clinical Study of Use of Remdesivir and Tocilizumab in Severely Ill COVID-19 Patients.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; COVID-19 Drug Treatment; Humans; Retrospective Studies; SARS-CoV-2 | 2021 |
Oxygen Sparing Effect of Bacteriotherapy in COVID-19.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Azithromycin; Blood Gas Analysis; Cell Line; COVID-19; Female; Heparin; Humans; Hypoxia; Italy; Lung; Male; Middle Aged; Oxygen; Probiotics; Prospective Studies | 2021 |
Clearance of the SARS-CoV-2 Virus in an Immunocompromised Patient Mediated by Convalescent Plasma without B-Cell Recovery.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; B-Lymphocytes; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Humans; Immunization, Passive; Immunocompromised Host; Rituximab; SARS-CoV-2; T-Lymphocytes; Vero Cells | 2021 |
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Benzothiazoles; Cell Line; Cell Survival; Coronavirus RNA-Dependent RNA Polymerase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Pyridones; SARS-CoV-2; Virus Replication | 2021 |
Convalescent plasma and remdesivir for protracted COVID-19 in a patient with chronic lymphocytic leukaemia: a case report of late relapse after rapid initial response.
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Humans; Immunization, Passive; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; SARS-CoV-2 | 2022 |
Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing.
Topics: Adenosine Monophosphate; Alanine; Alveolar Epithelial Cells; Antiviral Agents; Bleomycin; Cell Differentiation; Cell Line; Cell Survival; COVID-19 Drug Treatment; Host-Pathogen Interactions; Humans; Induced Pluripotent Stem Cells; Phenotype; SARS-CoV-2; Toxicity Tests; Virus Replication | 2021 |
Clinical Efficacy and Safety of Remdesivir among Hospitalised Adult Patients with RT PCR Confirmed COVID 19 Requiring ICU Care in Kalyana Karnataka.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Child; COVID-19 Drug Treatment; Cross-Sectional Studies; Humans; India; Intensive Care Units; Male; Middle Aged; Prospective Studies; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Treatment Outcome | 2021 |
Impact of remdesivir according to the pre-admission symptom duration in patients with COVID-19.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Male; Respiration, Artificial; Retrospective Studies; SARS-CoV-2 | 2021 |
Remdesivir-associated bradycardia.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; Bradycardia; COVID-19 Drug Treatment; Humans; Male; SARS-CoV-2 | 2021 |
Treatment of moderate to severe respiratory COVID-19: a cost-utility analysis.
Topics: Adenosine Monophosphate; Alanine; Clinical Decision-Making; Computer Simulation; Cost-Benefit Analysis; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Health Care Costs; Health Care Rationing; Humans; Intensive Care Units; Middle Aged; Oxygen; Quality-Adjusted Life Years; Respiration, Artificial; SARS-CoV-2; Severity of Illness Index; Treatment Outcome; United States | 2021 |
Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 11; Comorbidity; COVID-19 Drug Treatment; Drug Repositioning; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Lopinavir; Multidrug Resistance-Associated Protein 2; Organic Cation Transport Proteins; Ritonavir; SARS-CoV-2; Substrate Specificity | 2021 |
Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Dose-Response Relationship, Drug; Drug Interactions; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; HeLa Cells; Humans; Protein Binding; SARS-CoV-2 | 2021 |
Theaflavin-3'-O-gallate a Black-tea Constituent Blocked SARS CoV-2 RNA dependant RNA Polymerase Active-site with Better Docking Results than Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Biflavonoids; Catalytic Domain; Catechin; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; COVID-19 Drug Treatment; Drug Design; Enzyme Inhibitors; Gallic Acid; Molecular Docking Simulation; Protein Conformation; SARS-CoV-2; Structure-Activity Relationship | 2021 |
Remdesivir (Veklury) for the Treatment of COVID-19 in Hospitalized Patients.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Child; COVID-19 Drug Treatment; Drug Administration Schedule; Hospitalization; Humans; Practice Guidelines as Topic; SARS-CoV-2 | 2021 |
Deep learning identifies synergistic drug combinations for treating COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cell Survival; COVID-19 Drug Treatment; Deep Learning; Drug Combinations; Drug Interactions; Drug Synergism; Humans; SARS-CoV-2 | 2021 |
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.
Topics: Adenosine Monophosphate; Alanine; Animals; Binding Sites; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19; Crystallography, X-Ray; Humans; Indoles; Molecular Dynamics Simulation; Protease Inhibitors; Pyridines; SARS-CoV-2; Structure-Activity Relationship; Vero Cells | 2021 |
In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Biological Evolution; Chlorocebus aethiops; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Drug Resistance, Microbial; Humans; Mutation; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Vero Cells | 2021 |
Remdesivir, on the road to DisCoVeRy.
Topics: Adenosine Monophosphate; Alanine; Humans | 2022 |
Can the Antivirals Remdesivir and Favipiravir Work Better Jointly? In Silico Insights.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrazines; SARS-CoV-2 | 2022 |
Cost utility analysis of Remdesivir and Dexamethasone treatment for hospitalised COVID-19 patients - a hypothetical study.
Topics: Adenosine Monophosphate; Alanine; Cost-Benefit Analysis; COVID-19 Drug Treatment; Dexamethasone; Humans; SARS-CoV-2 | 2021 |
Safety and heart rate changes in Covid-19 patients treated with Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Heart Rate; Humans; SARS-CoV-2 | 2021 |
Prospect of compassionate use in China from remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials, Phase III as Topic; Compassionate Use Trials; Humans | 2021 |
New Drugs 2021, Part 2.
Topics: Adenosine Monophosphate; Alanine; Amisulpride; Carbamates; Cefiderocol; Cephalosporins; Chlorophenols; COVID-19 Drug Treatment; Drug Approval; Drug Combinations; Fumarates; Humans; Indans; Organophosphates; Oxadiazoles; Piperazines; Spiro Compounds; Tetrazoles; Thiophenes; Tromethamine; United States; United States Food and Drug Administration | 2021 |
Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; Ebolavirus; Fatty Acids; Humans; SARS-CoV-2 | 2021 |
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2.
Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Animals; Antiviral Agents; Clinical Studies as Topic; COVID-19 Drug Treatment; Humans; Mice; Rats | 2021 |
Remdesivir, Sinus Bradycardia and Therapeutic Drug Monitoring in Children With Severe COVID-19.
Topics: Adenosine Monophosphate; Alanine; Bradycardia; Child; COVID-19 Drug Treatment; Drug Monitoring; Humans; SARS-CoV-2 | 2021 |
Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus.
Topics: Adenosine Monophosphate; Administration, Intravenous; Aerosols; Alanine; Animals; Antiviral Agents; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Kaplan-Meier Estimate; Liver; Lung; Lymph Nodes; Macaca mulatta; Male; Random Allocation; Systemic Inflammatory Response Syndrome; Viral Load; Viremia | 2021 |
Remdesivir Treatment in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19): A Comparative Analysis of In-hospital All-cause Mortality in a Large Multicenter Observational Cohort.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Hospitals; Humans; Oxygen; Respiration, Artificial; SARS-CoV-2 | 2022 |
SARS-CoV-2 Infection in an Adolescent With X-linked Agammaglobulinemia.
Topics: Adenosine Monophosphate; Adolescent; Agammaglobulinemia; Alanine; Antibodies, Viral; Antiviral Agents; Biomarkers; Bronchoalveolar Lavage Fluid; COVID-19; COVID-19 Drug Treatment; Fever; Genetic Diseases, X-Linked; Humans; Inflammation; Male; Pneumonia, Viral; SARS-CoV-2 | 2021 |
Development of potent remdesivir derivative against SARS-CoV-2 protease inhibitors: Design, modification, molecular modeling and MD simulations.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Pandemics; Peptide Hydrolases; Protease Inhibitors; SARS-CoV-2; Viral Nonstructural Proteins | 2021 |
Update Alert 2: Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 2).
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Administration Schedule; Humans; SARS-CoV-2 | 2021 |
Update Alert 2: Remdesivir for Adults With COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Administration Schedule; Humans; SARS-CoV-2; Viral Load | 2021 |
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection.
Topics: Adenosine Monophosphate; Alanine; Alveolar Epithelial Cells; Animals; Antiviral Agents; Brain Stem; Cricetinae; Immunity, Innate; Inflammation; Lung; Models, Biological; Neurons; Organ Culture Techniques; Regulated Cell Death; SARS-CoV-2; Viral Tropism | 2021 |
Remdesivir induces persistent mitochondrial and structural damage in human induced pluripotent stem cell-derived cardiomyocytes.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Animals; Cardiotoxicity; COVID-19 Drug Treatment; Humans; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Nucleosides; Prodrugs | 2022 |
Antiviral effects of human placenta hydrolysate (Laennec
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; COVID-19 Drug Treatment; Female; Ferrets; Humans; Male; Placenta; Pregnancy; Protein Hydrolysates; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
Inhaled remdesivir treatment for COVID-19.
Topics: Adenosine Monophosphate; Administration, Inhalation; Alanine; COVID-19 Drug Treatment; Humans | 2021 |
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cell Line; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Models, Theoretical; Nucleotides; RNA, Viral; SARS-CoV-2; Stochastic Processes; Virus Replication | 2021 |
Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ.
Topics: Adenosine Monophosphate; Alanine; Cells, Cultured; COVID-19; COVID-19 Drug Treatment; DNA Polymerase gamma; DNA Replication; DNA, Mitochondrial; Fibroblasts; Humans; SARS-CoV-2 | 2021 |
Effect of drug metabolism in the treatment of SARS-CoV-2 from an entirely computational perspective.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Design; Drug Discovery; Humans; Metabolic Networks and Pathways; Molecular Docking Simulation; Nitro Compounds; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Thiazoles | 2021 |
COVID-19 survivors with calcineurin-inhibitors-treated rheumatoid arthritis.
Topics: Adenosine Monophosphate; Alanine; Arthritis, Rheumatoid; Calcineurin; Calcineurin Inhibitors; COVID-19 Drug Treatment; Dexamethasone; Humans; Survivors | 2022 |
COVID-19 in pediatric cancer patients is associated with treatment interruptions but not with short-term mortality: a Polish national study.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Child; Child, Preschool; COVID-19; COVID-19 Serotherapy; Disease Management; Female; Hematologic Neoplasms; Humans; Immunization, Passive; Infant; Male; Poland; SARS-CoV-2 | 2021 |
Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Cryoelectron Microscopy; Humans; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Viral Proteins; Virus Replication | 2021 |
Whole Body PBPK Modeling of Remdesivir and Its Metabolites to Aid in Estimating Active Metabolite Exposure in the Lung and Liver in Patients With Organ Dysfunction.
Topics: Adenosine Monophosphate; Adult; Alanine; Humans; Liver; Lung; Male; Models, Biological; Multiple Organ Failure; Tissue Distribution | 2022 |
Unmet need for COVID-19 therapies in community settings.
Topics: Adenosine Monophosphate; Alanine; Ambulatory Care; Antibodies, Monoclonal; Antiviral Agents; Community Health Services; COVID-19; COVID-19 Vaccines; Cytidine; Drug Combinations; Health Services Needs and Demand; Humans; Hydroxylamines; Socioeconomic Factors; Treatment Outcome; Viral Load | 2021 |
Transparency, health equity, and strategies in state-based protocols for remdesivir allocation and use.
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; Health Equity; Humans; Information Dissemination; Internet; Pandemics; SARS-CoV-2; United States | 2021 |
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Topics: Adenosine Monophosphate; Alanine; Animals; Chlorocebus aethiops; Coronavirus 229E, Human; Coronavirus 3C Proteases; Coronavirus Protease Inhibitors; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Design; Drug Synergism; Drug Therapy, Combination; HeLa Cells; Humans; Indoles; Infusions, Intravenous; Leucine; Mice; Pyrrolidinones; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus; Vero Cells | 2021 |
Real-world outcomes of COVID-19 treatment with remdesivir in a Spanish hospital.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Female; Hospitalization; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Retrospective Studies; Spain; Statistics, Nonparametric | 2021 |
Toxic myopathy and liver damage caused by concomitant therapy with remdesivir, atorvastatin, ezetimibe, and tacrolimus in a renal transplant patient with recently treated SARS-CoV-2 induced pneumonia: A case report.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Atorvastatin; COVID-19 Drug Treatment; Ezetimibe; Humans; Kidney Transplantation; Liver; Myotoxicity; Pneumonia; SARS-CoV-2; Tacrolimus | 2022 |
Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report.
Topics: Adenosine Monophosphate; Aged; Alanine; Antibodies, Monoclonal, Humanized; B-Lymphocytes; COVID-19; COVID-19 Serotherapy; Humans; Immunization, Passive; Killer Cells, Natural; SARS-CoV-2; T-Lymphocytes, Cytotoxic | 2021 |
Comparing the outcomes of treatment with INF-β 1-a (interferon beta-1a) and IFN-β 1-b (interferon beta-1b) among COVID-19 inpatients.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; Atazanavir Sulfate; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Female; Humans; Immunization, Passive; Inpatients; Intensive Care Units; Interferon beta-1a; Interferon beta-1b; Male; Middle Aged; Patient Discharge; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Treatment Outcome | 2021 |
Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro.
Topics: A549 Cells; Adenosine Monophosphate; Alanine; Amantadine; Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 Drug Treatment; Denmark; Drug Repositioning; Humans; Ion Channels; Memantine; Rimantadine; SARS-CoV-2; Vero Cells | 2021 |
Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: A retrospective cohort study.
Topics: Adenosine Monophosphate; Adult; Alanine; COVID-19 Drug Treatment; Hospitalization; Humans; Intensive Care Units; Male; Middle Aged; Retrospective Studies; Treatment Outcome | 2021 |
The shifting sands of 'gain-of-function' research.
Topics: Adaptation, Physiological; Adenosine Monophosphate; Alanine; Animals; Biomedical Research; Censorship, Research; Coronavirus; Dipeptidyl Peptidase 4; Evolution, Molecular; Ferrets; Gain of Function Mutation; Host Specificity; Humans; Influenza A Virus, H5N1 Subtype; Mice; Mutagenesis; Respiratory Tract Infections; Risk Assessment; Spike Glycoprotein, Coronavirus; Viral Vaccines | 2021 |
Specific delivering of RNAi using Spike's aptamer-functionalized lipid nanoparticles for targeting SARS-CoV-2: A strong anti-Covid drug in a clinical case study.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Alanine; Antiviral Agents; Aptamers, Nucleotide; Cell Line; COVID-19; COVID-19 Drug Treatment; Humans; Liposomes; Lung; Male; Nanoparticles; Protein Domains; Recombinant Proteins; RNA Interference; RNA, Small Interfering; SARS-CoV-2; SELEX Aptamer Technique; Severity of Illness Index; Spike Glycoprotein, Coronavirus; Viral Load | 2022 |
Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cardiovascular Diseases; COVID-19 Drug Treatment; Databases, Factual; Humans; Myocytes, Cardiac; Pharmacovigilance; Retrospective Studies; SARS-CoV-2; World Health Organization | 2022 |
Remdesivir; molecular and functional measures of mitochondrial safety.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; DNA-Directed RNA Polymerases; DNA, Mitochondrial; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Mitochondria; RNA, Messenger | 2021 |
Understanding the binding mechanism for potential inhibition of SARS-CoV-2 Mpro and exploring the modes of ACE2 inhibition by hydroxychloroquine.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; Binding Sites; Catalytic Domain; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Datasets as Topic; Drug Repositioning; Energy Transfer; Humans; Hydroxychloroquine; Lopinavir; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Receptors, Virus; Ritonavir; SARS-CoV-2 | 2022 |
Genomic diversity and molecular dynamics interaction on mutational variances among RB domains of SARS-CoV-2 interplay drug inactivation.
Topics: Adenosine Monophosphate; Alanine; Amino Acid Substitution; Antiviral Agents; Bangladesh; Binding Sites; China; COVID-19; COVID-19 Drug Treatment; Evolution, Molecular; Gene Expression; Genome, Viral; Humans; Likelihood Functions; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Netherlands; Phylogeny; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; SARS-CoV-2; Spike Glycoprotein, Coronavirus; United States | 2022 |
Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series.
Topics: Adenosine; Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Kidney; Renal Replacement Therapy | 2022 |
Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans.
Topics: Acetylcholinesterase; Adenosine Monophosphate; Alanine; Butyrylcholinesterase; Carboxylesterase; Cathepsin A; Humans; Hydrolysis; Kinetics; Liver; Microsomes, Liver; Simvastatin | 2022 |
Treatment of chronic or relapsing COVID-19 in immunodeficiency.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Alanine; Antibodies, Monoclonal; Antiviral Agents; B-Lymphocytes; Chronic Disease; COVID-19; COVID-19 Serotherapy; Female; Humans; Immunization, Passive; Immunologic Deficiency Syndromes; Lymphocyte Count; Male; Middle Aged; Recombinant Fusion Proteins; Recurrence; SARS-CoV-2; Treatment Failure | 2022 |
Potential kidney damage associated with the use of remdesivir for COVID-19: analysis of a pharmacovigilance database.
Topics: Adenosine Monophosphate; Adverse Drug Reaction Reporting Systems; Alanine; Brazil; COVID-19 Drug Treatment; Humans; Kidney; Pharmacovigilance; SARS-CoV-2 | 2021 |
Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction.
Topics: Adenosine; Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Body Surface Area; COVID-19; COVID-19 Drug Treatment; Drug Administration Schedule; Extracorporeal Membrane Oxygenation; Female; Glomerular Filtration Rate; Humans; Japan; Kidney Diseases; Male; Middle Aged; Monte Carlo Method; Precision Medicine; Retrospective Studies | 2022 |
Remdesivir and GS-441524 Extraction by Ex Vivo Extracorporeal Life Support Circuits.
Topics: Adenosine; Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; Extracorporeal Membrane Oxygenation; Humans; Renal Replacement Therapy | 2022 |
Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
Topics: Adenosine Monophosphate; Africa; Alanine; Amino Acid Substitution; Angiotensin-Converting Enzyme 2; Antiviral Agents; Asia; Binding Sites; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; COVID-19 Drug Treatment; Databases, Factual; Epidemiological Monitoring; Europe; Evolution, Molecular; Furin; Gene Expression; Genome, Viral; Humans; Molecular Docking Simulation; Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; SARS-CoV-2; Spike Glycoprotein, Coronavirus; United States; Viral Nonstructural Proteins | 2022 |
Experience in the use of remdesivir in patients with SARS-CoV-2 pneumonia.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome | 2021 |
Cost-Effectiveness of Combination of Baricitinib and Remdesivir in Hospitalized Patients with COVID-19 in the United States: A Modelling Study.
Topics: Adenosine Monophosphate; Alanine; Azetidines; Cost-Benefit Analysis; COVID-19 Drug Treatment; Humans; Purines; Pyrazoles; Quality-Adjusted Life Years; SARS-CoV-2; Sulfonamides; United States | 2022 |
Evaluation of the therapeutic regimen in COVID-19 in transplant patients: where do immunomodulatory and antivirals stand?
Topics: Adenosine Monophosphate; Aged; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; COVID-19 Testing; Female; Humans; Immunologic Factors; Iran; Length of Stay; Male; Middle Aged; Retrospective Studies; SARS-CoV-2; Transplant Recipients | 2021 |
Broad-Spectrum
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Glyceryl Ethers; Humans; Lipids; Nucleosides; Prodrugs; SARS-CoV-2 | 2021 |
Computational hunting of natural active compounds as an alternative for Remdesivir to target RNA-dependent polymerase.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Biological Products; Catalytic Domain; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Curcumin; Databases, Protein; Drug Discovery; Drug Evaluation, Preclinical; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Molecular Docking Simulation; Phytochemicals; Protein Binding; SARS-CoV-2; Silybin | 2021 |
Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Survival; Chlorocebus aethiops; Coronavirus Infections; Coronavirus NL63, Human; Emodin; Halogenation; Humans; Vero Cells | 2021 |
Assessing the evidence on remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome | 2021 |
Assessing the evidence on remdesivir.
Topics: Adenosine Monophosphate; Alanine; Humans | 2021 |
Perspectives of association Baricitinib/Remdesivir for adults with Covid-19 infection.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Azetidines; COVID-19 Drug Treatment; Cytokine Release Syndrome; Drug Combinations; Humans; Immunologic Factors; Pandemics; Purines; Pyrazoles; Sulfonamides | 2022 |
Retrospective modelling of hospital bed capacities associated with the administration of remdesivir during the first wave of COVID-19 in a German metropolitan city.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Hospital Bed Capacity; Humans; Retrospective Studies; SARS-CoV-2 | 2022 |
Risk factors and incidence of long-COVID syndrome in hospitalized patients: does remdesivir have a protective effect?
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; Hospitalization; Humans; Incidence; Intensive Care Units; Post-Acute COVID-19 Syndrome; Prospective Studies; Risk Factors; SARS-CoV-2 | 2022 |
Case Report: Severe SARS-CoV-2 Infection Treated with Remdesivir in a Patient with ESRD.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Kidney Failure, Chronic; Male; Middle Aged; Respiratory Distress Syndrome; SARS-CoV-2 | 2022 |
Direct and Catalytic C-Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Catalysis; Chemistry Techniques, Synthetic; COVID-19 Drug Treatment; Cyclization; Glycosylation; Humans; Models, Molecular; Nucleosides; Stereoisomerism; Time Factors | 2022 |
Molecular interactions in remdesivir-cyclodextrin systems.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Cyclodextrins; Humans; SARS-CoV-2; Solubility | 2022 |
Safety of Remdesivir for Patients 80 Years of Age or Older with Coronavirus Disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Retrospective Studies; SARS-CoV-2 | 2021 |
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target.
Topics: A549 Cells; Adenosine Monophosphate; Alanine; Antiviral Agents; Exoribonucleases; Humans; SARS-CoV-2; Viral Nonstructural Proteins; Viral Regulatory and Accessory Proteins; Virus Replication | 2022 |
Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Benzoquinones; Cell Line; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Drug Discovery; Drug Synergism; High-Throughput Screening Assays; Humans; Lactams, Macrocyclic; Lapatinib; Naphthalenes; Phenylurea Compounds; Pyrazoles; RNA, Viral; SARS-CoV-2; Vero Cells; Virus Replication | 2022 |
Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antiviral Agents; Binding Sites; Cell Culture Techniques; Cell Line; Coronavirus NL63, Human; Haplorhini; Humans; Molecular Docking Simulation; Pyrazines; RNA-Dependent RNA Polymerase; Virus Replication | 2021 |
Bradycardia during remdesivir treatment might be associated with improved survival in patients with COVID-19: a retrospective cohort study on 473 patients from a tertiary centre.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bradycardia; COVID-19 Drug Treatment; Humans; Retrospective Studies | 2022 |
Chemical Synthesis of the Anti-COVID-19 Drug Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pharmaceutical Preparations; SARS-CoV-2 | 2021 |
Real-World Effectiveness of Remdesivir in Adults Hospitalized With Coronavirus Disease 2019 (COVID-19): A Retrospective, Multicenter Comparative Effectiveness Study.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Female; Humans; Male; Retrospective Studies; SARS-CoV-2; United States | 2022 |
Neuropsychological adverse drug reactions of Remdesivir: analysis using VigiBase, the WHO global database of individual case safety reports.
Topics: Adenosine Monophosphate; Adverse Drug Reaction Reporting Systems; Alanine; Bayes Theorem; Cohort Studies; Databases, Factual; Humans; Nervous System Diseases; Pharmacovigilance; Psychological Distress; Stress, Psychological; World Health Organization | 2021 |
Audio Interview: A Potential New Agent to Treat Covid-19.
Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Evolution, Molecular; Hospitalization; Humans; Hydroxylamines; Mutagenesis; Risk Assessment; SARS-CoV-2; Time-to-Treatment; Vaccine Efficacy; Viral Load; Virus Replication | 2021 |
The Goldilocks Time for Remdesivir - Is Any Indication Just Right?
Topics: Adenosine Monophosphate; Alanine; Humans | 2022 |
Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Treated with Remdesivir, Glucocorticoids, and Hyperimmune Plasma.
Topics: Adenosine Monophosphate; Alanine; Child; COVID-19 Drug Treatment; Glucocorticoids; Humans; Infant; Infant, Newborn; Infant, Premature; SARS-CoV-2; Venous Thrombosis | 2021 |
Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Hepacivirus; Models, Molecular; Negative-Sense RNA Viruses; Nipah Virus; Positive-Strand RNA Viruses; RNA Viruses; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Virus Replication | 2022 |
Real-world treatment patterns and clinical outcomes for inpatients with COVID-19 in the US from September 2020 to February 2021.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Anti-Inflammatory Agents; Antiviral Agents; Comorbidity; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Obesity; Patient Discharge; Retrospective Studies; RNA, Viral; SARS-CoV-2; Treatment Outcome; United States; Young Adult | 2021 |
Remdesivir: Mechanism of Metabolic Conversion from Prodrug to Drug.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Nerve Tissue Proteins; Pandemics; Prodrugs | 2022 |
Audio Interview: Covid-19 Vaccination and the Omicron Variant.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; COVID-19; COVID-19 Vaccines; Disease Transmission, Infectious; Drug Approval; Hospitalization; Humans; Immunogenicity, Vaccine; SARS-CoV-2; Time Factors; Time-to-Treatment; Vaccine Efficacy | 2021 |
Assessment of Safety of Remdesivir in Covid - 19 Patients with Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min per 1.73 m^2.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Adult; Alanine; COVID-19 Drug Treatment; Creatinine; Female; Glomerular Filtration Rate; Humans; Male; Retrospective Studies | 2022 |
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chlorocebus aethiops; COVID-19 Drug Treatment; Humans; Primates; SARS-CoV-2; Viral Load | 2022 |
[Remdesivir for COVID-19].
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Hemorrhagic Fever, Ebola; Hepatitis C, Chronic; Humans; SARS-CoV-2 | 2022 |
Safety and clinical outcomes of remdesivir in hospitalised COVID-19 patients: a retrospective analysis of active surveillance database.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Male; Middle Aged; Retrospective Studies; SARS-CoV-2; Treatment Outcome; Watchful Waiting | 2022 |
Should remdesivir be recommended in France in the early stage of COVID-19.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; France; Humans; SARS-CoV-2 | 2022 |
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Humans; In Situ Hybridization; In Situ Hybridization, Fluorescence; Microscopy, Electron; Reproducibility of Results; RNA, Viral; SARS-CoV-2; Sensitivity and Specificity; Vero Cells; Virus Release; Virus Replication | 2022 |
Remdesivir-associated bradycardia might be a sign of good prognosis in COVID-19 patients.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bradycardia; COVID-19 Drug Treatment; Humans; Prognosis | 2022 |
Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibitors.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Cellulose; Computational Biology; Coronavirus RNA-Dependent RNA Polymerase; Molecular Docking Simulation; Molecular Dynamics Simulation; Nucleosides; Pyrolysis; SARS-CoV-2 | 2022 |
Comparative Greenness Metric Estimates for Content Uniformity Testing of Anti-Cov-2, GS-5734 in Commercial Vials: Validated Micellar Electrokinetic Chromatographic Assay.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, Micellar Electrokinetic Capillary; COVID-19 Drug Treatment; Humans; Micelles; Reproducibility of Results | 2022 |
Remdesivir and dexamethasone as tools to relieve hospital care systems stressed by COVID-19: A modelling study on bed resources and budget impact.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bed Occupancy; COVID-19; COVID-19 Drug Treatment; Dexamethasone; France; Hospitalization; Humans; Intensive Care Units; Length of Stay; Models, Statistical; SARS-CoV-2 | 2022 |
Remdesivir retreatment: another unproven intervention for COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Inpatient COVID-19 mortality has reduced over time: Results from an observational cohort.
Topics: Adenosine Monophosphate; Aged; Alanine; Cohort Studies; Comorbidity; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Female; Hospital Mortality; Hospitalization; Humans; Inpatients; London; Male; Middle Aged; Pandemics; Patient Discharge; Proportional Hazards Models | 2022 |
COVID-19 Therapeutics for Nonhospitalized Patients.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; Child; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Female; Health Care Rationing; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Outpatients; Pregnancy; Proline; Ritonavir | 2022 |
Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2.
Topics: Adenosine Monophosphate; Administration, Cutaneous; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Disease Models, Animal; Female; Lung; Lung Diseases, Interstitial; Macaca mulatta; Male; SARS-CoV-2; Viral Load; Virus Replication | 2022 |
Very low levels of remdesivir resistance in SARS-COV-2 genomes after 18 months of massive usage during the COVID19 pandemic: A GISAID exploratory analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Drug Resistance, Viral; Genome, Viral; Humans; Polyproteins; RNA-Dependent RNA Polymerase; SARS-CoV-2; Viral Proteins | 2022 |
The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; SARS-CoV-2; Signal Transduction; Virus Activation | 2022 |
Remdesivir significantly reduces SARS-CoV-2 viral load on nasopharyngeal swabs in hospitalized patients with COVID-19: A retrospective case-control study.
Topics: Adenosine Monophosphate; Alanine; Case-Control Studies; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Humans; Nasopharynx; Retrospective Studies; SARS-CoV-2; Viral Load | 2022 |
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Outpatients; SARS-CoV-2 | 2022 |
Racial and Ethnic Disparities in Receipt of Medications for Treatment of COVID-19 - United States, March 2020-August 2021.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal; COVID-19 Drug Treatment; Dexamethasone; Ethnic and Racial Minorities; Ethnicity; Health Services Accessibility; Healthcare Disparities; Humans; Social Determinants of Health; United States | 2022 |
Risk Factors for Therapeutic Intervention of Remdesivir in Mild to Moderate COVID-19-A Single-Center Retrospective Study of the COVID-19 Fourth Pandemic Period in Wakayama, Japan.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Japan; Middle Aged; Pandemics; Retrospective Studies; Risk Factors; SARS-CoV-2 | 2022 |
Why scientists are racing to develop more COVID antivirals.
Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Approval; Drug Combinations; Drug Development; Drug Resistance, Viral; Drug Therapy, Combination; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Medication Adherence; Molecular Targeted Therapy; Mutagenesis; Nitriles; Proline; Public-Private Sector Partnerships; Research Personnel; Ritonavir; SARS-CoV-2 | 2022 |
Impact of cytokine storm on severity of COVID-19 disease in a private hospital in West Jakarta prior to vaccination.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Comorbidity; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Female; Hospitals, Private; Humans; Immunization, Passive; Indonesia; Male; Middle Aged; Vaccination; Vitamins | 2022 |
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Microbial Sensitivity Tests; Nitriles; Proline; RNA-Dependent RNA Polymerase; SARS-CoV-2; Vero Cells; Virus Replication | 2022 |
Successful treatment with a short course of remdesivir in a case of prolonged COVID-19 in a lymphoma patient.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Lymphoma; SARS-CoV-2 | 2022 |
Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Ivermectin; SARS-CoV-2 | 2022 |
A Comment on "Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites".
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Cytidine; Humans; Nucleosides; SARS-CoV-2 | 2022 |
Response to Comments on "Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites".
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Cytidine; Humans; Nucleosides; SARS-CoV-2 | 2022 |
Successful management of remdesivir extravasation.
Topics: Adenosine Monophosphate; Alanine; Humans | 2022 |
Early Use of Remdesivir and Risk of Disease Progression in Hospitalized Patients With Mild to Moderate COVID-19.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Disease Progression; Humans; Pneumonia; Prospective Studies | 2022 |
Early Administration of Remdesivir and Intensive Care Unit Admission in Hospitalized Pregnant Individuals With Coronavirus Disease 2019 (COVID-19).
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Female; Hospitalization; Humans; Intensive Care Units; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; SARS-CoV-2 | 2022 |
Treatment of COVID-19 in high-risk outpatients.
Topics: Adenosine Monophosphate; Alanine; Ambulatory Care; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Outpatients; Proline; Ritonavir; Treatment Outcome | 2022 |
Association of Treatment with Remdesivir and 30-day Hospital Readmissions in Patients Hospitalized with COVID-19.
Topics: Adenosine Monophosphate; Adult; Aftercare; Alanine; Cohort Studies; COVID-19 Drug Treatment; Hospitalization; Hospitals; Humans; Pandemics; Patient Discharge; Patient Readmission; Prospective Studies; Retrospective Studies; SARS-CoV-2 | 2022 |
Remdesivir for the Treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Treatment Outcome | 2022 |
COVID-19 updates: Remdesivir (Veklury) in high-risk outpatients with COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Outpatient Remdesivir to Prevent Progression to Severe Covid-19.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Outpatients | 2022 |
Outpatient Remdesivir to Prevent Progression to Severe Covid-19. Reply.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Outpatients | 2022 |
Remdesivir in combination with dexamethasone for patients hospitalized with COVID-19: A retrospective multicenter study.
Topics: Adenosine Monophosphate; Aged; Alanine; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Drug Therapy, Combination; Female; Follow-Up Studies; France; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; SARS-CoV-2; Survival Rate | 2022 |
The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its application in remdesivir pharmacokinetics study for pediatric patients.
Topics: Adenosine Monophosphate; Alanine; beta-Cyclodextrins; Child; Chromatography, Liquid; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Sodium; Tandem Mass Spectrometry | 2022 |
The Cost-Effectiveness of Remdesivir for Hospitalized Patients With COVID-19.
Topics: Adenosine Monophosphate; Alanine; Cost-Benefit Analysis; COVID-19 Drug Treatment; Humans; Quality-Adjusted Life Years | 2022 |
Most published systematic reviews of remdesivir for COVID-19 were redundant and lacked currency.
Topics: Adenosine Monophosphate; Alanine; Australia; COVID-19 Drug Treatment; Cross-Sectional Studies; Humans; Systematic Reviews as Topic | 2022 |
Effectiveness of remdesivir in hospitalized nonsevere patients with COVID-19 in Japan: A large observational study using the COVID-19 Registry Japan.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Japan; Oxygen; Registries; SARS-CoV-2 | 2022 |
Comparative outcomes of combined corticosteroid and remdesivir therapy with corticosteroid monotherapy in ventilated COVID-19 patients.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Aged; Alanine; Cohort Studies; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Female; Hospital Mortality; Humans; Incidence; Kaplan-Meier Estimate; Length of Stay; Male; Middle Aged; Proportional Hazards Models; Pseudomonas Infections; Respiration, Artificial; SARS-CoV-2; Staphylococcal Infections; Treatment Outcome | 2022 |
A Cost-Effectiveness Analysis of Remdesivir for the Treatment of Hospitalized Patients With COVID-19 in England and Wales.
Topics: Adenosine Monophosphate; Alanine; Cost-Benefit Analysis; COVID-19 Drug Treatment; Humans; Quality of Life; Quality-Adjusted Life Years; State Medicine; Wales | 2022 |
SARS-CoV-2 Associated Respiratory Failure in a Preterm Infant and the Outcome after Remdesivir Treatment.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Infant; Infant, Newborn; Infant, Premature; Respiratory Insufficiency; SARS-CoV-2 | 2022 |
Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells.
Topics: Adenosine Monophosphate; Alanine; Alveolar Epithelial Cells; Antiviral Agents; Cell Line; Chloroquine; COVID-19 Drug Treatment; Drug Repositioning; Humans; Mefloquine; SARS-CoV-2; Serine Endopeptidases; Virus Internalization | 2022 |
Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 2, Update Alert 3).
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Physicians | 2022 |
The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cobicistat; COVID-19 Drug Treatment; Cricetinae; Disease Progression; Hepatitis C, Chronic; Humans; Mesocricetus; Pandemics; SARS-CoV-2; Viral Load | 2022 |
Hundreds of COVID trials could provide a deluge of new drugs.
Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Neutralizing; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Depsipeptides; Dexamethasone; Drug Combinations; Drug Repositioning; Drug Synergism; Esters; Guanidines; Hospitalization; Host-Pathogen Interactions; Humans; Hydroxylamines; Internationality; Lactams; Leucine; Mice; National Institutes of Health (U.S.); Nitriles; Peptide Elongation Factor 1; Peptides, Cyclic; Proline; Protease Inhibitors; Ritonavir; RNA-Dependent RNA Polymerase; SARS-CoV-2; Serine Endopeptidases; Sodium-Glucose Transporter 2 Inhibitors; United States; Virus Replication | 2022 |
Remdesivir for Outpatient Management: Time to Wait, Not to Act.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Outpatients | 2022 |
Remdesivir use in COVID-19 patients with end-stage kidney disease on intermittent hemodialysis: An absolute contraindication?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Contraindications; COVID-19 Drug Treatment; Humans; Kidney Failure, Chronic; Renal Dialysis | 2022 |
Concerns about subgroup analyses and reason for stopping remdesivir trial.
Topics: Adenosine Monophosphate; Alanine; Humans | 2022 |
The authors respond to "Concerns about subgroup analyses and reason for stopping remdesivir trial".
Topics: Adenosine Monophosphate; Alanine; Humans | 2022 |
Estimation Model for Healthcare Costs and Intensive Care Units Access for Covid-19 Patients and Evaluation of the Effects of Remdesivir in the Portuguese Context: Hypothetical Study.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Health Care Costs; Humans; Intensive Care Units; Portugal; SARS-CoV-2 | 2022 |
COVID-19 and kidney transplantation: the impact of remdesivir on renal function and outcome - a retrospective cohort study.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Kidney; Kidney Transplantation; Retrospective Studies; SARS-CoV-2 | 2022 |
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Female; Humans; Immunocompromised Host; Mutation; SARS-CoV-2 | 2022 |
Postmarketing pharmacovigilance: Remdesivir and cardiovascular events.
Topics: Adenosine Monophosphate; Alanine; Cardiovascular Diseases; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacovigilance; Product Surveillance, Postmarketing | 2022 |
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Chlorocebus aethiops; Common Cold; Coronavirus Infections; Coronavirus OC43, Human; COVID-19 Drug Treatment; Cytokines; Drug Synergism; Humans; Isothiocyanates; Lung; Macrophages, Alveolar; Male; Mice, Transgenic; SARS-CoV-2; Spleen; Sulfoxides; T-Lymphocytes; Vero Cells; Viral Load | 2022 |
Cost-Effectiveness of Remdesivir for COVID-19 Treatment: What Are We Missing?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cost-Benefit Analysis; COVID-19 Drug Treatment; Humans | 2022 |
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Coronavirus Infections; COVID-19 Drug Treatment; Humans; Mice; Nucleosides; Parents; Prodrugs; SARS-CoV-2 | 2022 |
Efficacy of the combination of baricitinib, remdesivir, and dexamethasone in hypoxic adults with COVID-19: A retrospective study.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Azetidines; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Humans; Purines; Pyrazoles; Retrospective Studies; SARS-CoV-2; Sulfonamides | 2022 |
Remdesivir use and risks of acute kidney injury and acute liver injury among patients hospitalised with COVID-19: a self-controlled case series study.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Hong Kong; Humans; Liver; Retrospective Studies; Risk Factors; SARS-CoV-2 | 2022 |
Aurasperone A Inhibits SARS CoV-2 In Vitro: An Integrated In Vitro and In Silico Study.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Aspergillus niger; Chlorocebus aethiops; Chromones; Coronavirus 3C Proteases; Coronavirus Papain-Like Proteases; Coronavirus RNA-Dependent RNA Polymerase; Molecular Docking Simulation; Protease Inhibitors; RNA Helicases; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Vero Cells | 2022 |
Viable SARS-CoV-2 shedding under remdesivir and dexamethasone treatment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Dexamethasone; Humans; SARS-CoV-2 | 2022 |
Acute pancreatitis or severe increase in pancreatic enzyme levels following remdesivir administration in COVID-19 patients: an observational study.
Topics: Acute Disease; Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Pancreatitis; Retrospective Studies | 2022 |
Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chromatography, Liquid; COVID-19 Drug Treatment; Diabetes Mellitus; Diabetic Nephropathies; Mice; Mice, Inbred DBA; Nucleosides; Tandem Mass Spectrometry | 2022 |
Use of Remdesivir in the treatment of Coronavirus Disease 2019 (COVID-19) infection among Sudanese patients: a case series.
Topics: Adenosine Monophosphate; Aged; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Male; SARS-CoV-2 | 2021 |
Spectrophotometric quantitative analysis of remdesivir using acid dye reagent selected by computational calculations.
Topics: Adenosine Monophosphate; Alanine; Bromphenol Blue; Child; Coloring Agents; COVID-19 Drug Treatment; Humans; Indicators and Reagents; Pharmaceutical Preparations; United States | 2022 |
Potential Effects of Ibuprofen, Remdesivir and Omeprazole on Dexamethasone Metabolism in Control Sprague Dawley Male Rat Liver Microsomes (Drugs Often Used Together Alongside COVID-19 Treatment).
Topics: Adenosine Monophosphate; Alanine; Animals; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Ibuprofen; Isoenzymes; Male; Microsomes, Liver; Omeprazole; Rats; Rats, Sprague-Dawley | 2022 |
Remdesivir treatment in hospitalized patients affected by COVID-19 pneumonia: A case-control study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Case-Control Studies; COVID-19 Drug Treatment; Humans; SARS-CoV-2; Treatment Outcome | 2022 |
Combination therapy with remdesivir and monoclonal antibodies protects nonhuman primates against advanced Sudan virus disease.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibodies, Monoclonal; Antibodies, Viral; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Macaca mulatta; Marburgvirus; Virus Diseases | 2022 |
Comparative bioavailability study following a single dose intravenous and buccal administration of remdesivir in rabbits.
Topics: Adenosine Monophosphate; Administration, Buccal; Administration, Intravenous; Alanine; Animals; Antiviral Agents; Biological Availability; COVID-19 Drug Treatment; Furans; Humans; Pyrroles; Rabbits; SARS-CoV-2; Triazines | 2022 |
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model.
Topics: Adenosine Monophosphate; Alanine; Animals; Mice; Respiratory Syncytial Virus, Human | 2022 |
Impact of Remdesivir Incorporation along the Primer Strand on SARS-CoV-2 RNA-Dependent RNA Polymerase.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2 | 2022 |
Mortality comparision in patients receiving either Remdesivir or Remdesivir plus Baricitinib combination in case of moderate to severe COVID-19 Pneumonia: A retrospective study.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Azetidines; COVID-19 Drug Treatment; Humans; Purines; Pyrazoles; Retrospective Studies; SARS-CoV-2; Sulfonamides | 2022 |
Amphiphilic anti-SARS-CoV-2 drug remdesivir incorporates into the lipid bilayer and nerve terminal membranes influencing excitatory and inhibitory neurotransmission.
Topics: Adenosine Monophosphate; Alanine; Animals; COVID-19 Drug Treatment; gamma-Aminobutyric Acid; Lipid Bilayers; Rats; Rats, Wistar; SARS-CoV-2; Synaptic Transmission | 2022 |
Clinical course of patients with severe COVID-19 pneumonia treated with remdesivir: A real-life study.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Respiration, Artificial; Retrospective Studies | 2022 |
Remdesivir plus Dexamethasone in COVID-19: A cohort study of severe patients requiring high flow oxygen therapy or non-invasive ventilation.
Topics: Adenosine Monophosphate; Alanine; Cohort Studies; COVID-19 Drug Treatment; Critical Illness; Dexamethasone; Humans; Noninvasive Ventilation; Oxygen; Prospective Studies | 2022 |
Linear mixed model analysis to evaluate correlations between remdesivir adverse effects with age and gender of patients with mild Covid-19 pneumonia.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Creatinine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male | 2022 |
Journey of remdesivir from the inhibition of hepatitis C virus to the treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Hepacivirus; Humans; Pandemics; SARS-CoV-2 | 2022 |
In high-risk outpatients with COVID-19, remdesivir reduced COVID-19-related hospitalization or all-cause death at 28 d.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Hospitalization; Humans; Outpatients; SARS-CoV-2 | 2022 |
Report of a combination of remdesivir, intravenous methylprednisolone pulse, and tocilizumab for severe coronavirus disease: 20-case series at a single institution.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; COVID-19 Drug Treatment; Humans; Methylprednisolone; SARS-CoV-2 | 2022 |
Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Endothelial Cells; Histamine Antagonists; Inflammation; Lung Injury; Mice; Rodent Diseases; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2022 |
Covid-19: Remdesivir has "small effect" against death or progression to ventilation, WHO trial finds.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Treatment Outcome; World Health Organization | 2022 |
The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Dyslipidemias; Humans; Obesity; SARS-CoV-2 | 2022 |
When and which patients should receive remdesivir?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Humans | 2022 |
Remdesivir use in COVID-19 patients might predispose bacteremia, matched case-control analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Bacteremia; COVID-19 Drug Treatment; Humans | 2022 |
Nanoformulated Remdesivir with Extremely Low Content of Poly(2-oxazoline)-Based Stabilizer for Aerosol Treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Excipients; Humans; Oxazoles; Respiratory Aerosols and Droplets; RNA, Viral; SARS-CoV-2 | 2022 |
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Remdesivir efficacy against yellow fever in a hamster model.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cricetinae; Viremia; Yellow Fever; Yellow Fever Vaccine; Yellow fever virus | 2022 |
Early remdesivir to prevent severe COVID-19 in recipients of solid organ transplant: a real-life study from Northern Italy.
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; Humans; Organ Transplantation; Retrospective Studies; SARS-CoV-2; Transplant Recipients | 2022 |
Survival benefit of remdesivir in hospitalized COVID-19 patients with high SARS-CoV-2 viral loads and low-grade systemic inflammation.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cohort Studies; COVID-19 Drug Treatment; Dexamethasone; Humans; Inflammation; SARS-CoV-2; Viral Load | 2022 |
Editorial: liver and kidney injury from remdesivir-an issue not as much as its purpose. Authors' reply.
Topics: Adenosine Monophosphate; Alanine; Humans; Kidney; Liver | 2022 |
Editorial: liver and kidney injury from remdesivir-an issue not as much as its purpose.
Topics: Adenosine Monophosphate; Alanine; Humans; Kidney; Liver | 2022 |
Dexamethasone and remdesivir: finding method in the COVID-19 madness.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Dexamethasone; Humans | 2020 |
Spectrofluorimetric determination of the anti-Covid 19 agent, remdesivir, in vials and spiked human plasma.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Micelles; Spectrometry, Fluorescence | 2022 |
The mechanism and effects of remdesivir-induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations.
Topics: Adenosine Monophosphate; Alanine; Animals; COVID-19 Drug Treatment; Ecosystem; Embryo, Nonmammalian; Hepatocyte Nuclear Factor 1-beta; Larva; Water Pollutants, Chemical; Zebrafish; Zebrafish Proteins | 2022 |
Atrial fibrillation in COVID-19 patients receiving remdesivir, matched case-control analysis.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Atrial Fibrillation; COVID-19 Drug Treatment; Humans | 2022 |
Remdesivir-Induced Liver Injury in a COVID-Positive Newborn.
Topics: Adenosine Monophosphate; Alanine; Chemical and Drug Induced Liver Injury, Chronic; COVID-19 Drug Treatment; Humans; Infant, Newborn | 2022 |
Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations.
Topics: Adenosine Monophosphate; Alanine; Animals; Blastocyst; COVID-19 Drug Treatment; Embryonic Development; Female; Mice; Pregnancy; Pregnancy Complications, Infectious | 2022 |
Estimating the effectiveness of remdesivir on risk of COVID-19 mortality: The role of observational data.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Treatment Outcome | 2022 |
Final results of the DisCoVeRy trial of remdesivir for patients admitted to hospital with COVID-19.
Topics: Adenosine Monophosphate; Alanine; Clinical Trials as Topic; COVID-19 Drug Treatment; Hospitalization; Humans | 2022 |
Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; COVID-19 Drug Treatment; Critical Illness; Furans; Humans; Monte Carlo Method; Triazines | 2022 |
COVID-19 update: Remdesivir (Veklury) FDA-approved for children <12 years old.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Child; COVID-19 Drug Treatment; Humans | 2022 |
Pharmacogenetic variants and risk of remdesivir-associated liver enzyme elevations in Million Veteran Program participants hospitalized with COVID-19.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Liver; Pharmacogenomic Variants; Retrospective Studies; SARS-CoV-2; Veterans | 2022 |
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology - A Proof-of-Concept Model Development for Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Calibration; COVID-19 Drug Treatment; Humans; Network Pharmacology; SARS-CoV-2 | 2022 |
No effect of remdesivir or betamethasone on upper respiratory tract SARS-CoV-2 RNA kinetics in hospitalised COVID-19 patients: a retrospective observational study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betamethasone; COVID-19 Drug Treatment; Female; Humans; Male; Middle Aged; Nasopharynx; Retrospective Studies; RNA, Viral; SARS-CoV-2 | 2022 |
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Drug-Membrane Interactions: Effects of Virus-Specific RNA-Dependent RNA Polymerase Inhibitors Remdesivir and Favipiravir on the Structure of Lipid Bilayers.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Humans; Lipid Bilayers; Pyrazines; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2022 |
Mortality in SARS-CoV-2 Hospitalized Patients Treated with Remdesivir: A Nationwide, Registry-Based Study in Italy.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; COVID-19 Testing; Humans; Italy; Registries; SARS-CoV-2 | 2022 |
Insights on the Quantitative Concurrent Fluorescence-Based Analysis of Anti-COVID-19 Drugs Remdesivir and Favipiravir.
Topics: Adenosine Monophosphate; Alanine; Amides; COVID-19 Drug Treatment; Humans; Pandemics; Pyrazines; SARS-CoV-2 | 2022 |
Remdesivir powders manufactured by jet milling for potential pulmonary treatment of COVID-19.
Topics: Adenosine Monophosphate; Administration, Inhalation; Alanine; COVID-19 Drug Treatment; Dry Powder Inhalers; Excipients; Humans; Lactose; Particle Size; Powders; Respiratory Aerosols and Droplets; Water | 2022 |
D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Aspirin; COVID-19 Drug Treatment; Glycine; Humans; Lysine; SARS-CoV-2 | 2022 |
Early administration of remdesivir plus convalescent plasma therapy is effective to treat COVID-19 pneumonia in B-cell depleted patients with hematological malignancies.
Topics: Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Hematologic Neoplasms; Humans; Immunization, Passive; Lymphopenia; Oxygen; SARS-CoV-2 | 2022 |
Modeling the Potential Impact of Remdesivir Treatment for Hospitalized Patients with COVID-19 in Saudi Arabia on Healthcare Resource Use and Direct Hospital Costs: A Hypothetical Study.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Health Care Costs; Hospitals; Humans; SARS-CoV-2; Saudi Arabia | 2022 |
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjects.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Transaminases; Triazines | 2022 |
Drug-drug interaction between remdesivir and immunosuppressant agents in a kidney transplant recipient.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Cytochrome P-450 Enzyme System; Delayed-Action Preparations; Drug Interactions; Everolimus; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Methylprednisolone; Middle Aged; Tacrolimus | 2022 |
Spectrofluorimetric quantitative analysis of favipiravir, remdesivir and hydroxychloroquine in spiked human plasma.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Pyrazines; SARS-CoV-2; Spectrometry, Fluorescence | 2022 |
Remdesivir (VEKLURY) for Treating COVID-19: Guinea Pig Ex Vivo and In Vivo Cardiac Electrophysiological Effects.
Topics: Action Potentials; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Bradycardia; COVID-19 Drug Treatment; Electrocardiography; Guinea Pigs; Long QT Syndrome; Male | 2022 |
Remdesivir modifies interferon response in hospitalized COVID-19 patients.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Interferons | 2022 |
Combination therapy with remdesivir and immunomodulators improves respiratory status in COVID-19: A retrospective study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Azetidines; COVID-19 Drug Treatment; Humans; Immunologic Factors; Oxygen; Purines; Pyrazoles; Retrospective Studies; SARS-CoV-2; Sulfonamides | 2022 |
COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increased Levels of Donor-Specific Antibodies Among Kidney Transplant Recipients Hospitalized With COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antibodies; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Graft Rejection; HLA Antigens; Humans; Kidney Transplantation; Pandemics; SARS-CoV-2; Transplant Recipients; Vaccination | 2022 |
A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA Polymerase.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Nucleotides; Pandemics; RNA, Viral; SARS-CoV-2 | 2022 |
In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivir.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Cannabidiol; Carboxylic Ester Hydrolases; COVID-19 Drug Treatment; Humans; Hydrolysis; Prodrugs | 2022 |
Use of remdesivir in kidney transplant recipients with SARS-CoV-2 Omicron infection.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Kidney Transplantation; SARS-CoV-2; Transplant Recipients | 2022 |
Major Update 2: Remdesivir for Adults With COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans | 2022 |
Major Update 2: Remdesivir for Adults With COVID-19.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans | 2022 |
Clinical Characteristics and Implications of Bradycardia in COVID-19 Patients Treated with Remdesivir: A Single-Center Retrospective Cohort Study.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; Bradycardia; COVID-19 Drug Treatment; Humans; Male; Middle Aged; Retrospective Studies; SARS-CoV-2 | 2022 |
Nirmatrelvir-remdesivir association for non-hospitalized adults with COVID-19, point of view.
Topics: Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19 Drug Treatment; Hospitalization; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2022 |
Evaluation of Remdesivir for Mildly to Moderately Ill Patients with COVID-19: A Single-Arm, Single-Center, Retrospective Study.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Oxygen; Retrospective Studies; SARS-CoV-2 | 2022 |
A novel logical model of COVID-19 intracellular infection to support therapies development.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2 | 2022 |
Long-term survival benefit of male and multimorbid COVID-19 patients with 5-day remdesivir treatment.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Coronavirus; Coronavirus Infections; COVID-19 Drug Treatment; Humans; Male; Pandemics; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; SARS-CoV-2 | 2022 |
Structural Insights into Binding of Remdesivir Triphosphate within the Replication-Transcription Complex of SARS-CoV-2.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Antiviral Agents; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Deoxyribonucleotides; Hydrogen; Nucleotides; Ribonucleotides; RNA, Viral; SARS-CoV-2 | 2022 |
Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Lung; Nucleosides; Prodrugs; SARS-CoV-2 | 2022 |
Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19 Drug Treatment; Disease Progression; Humans; Pandemics; Pneumonia, Viral; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2 | 2022 |
Considerations and Challenges in the Remdesivir COVID-19 Pediatric Development Program.
Topics: Adenosine Monophosphate; Adolescent; Adult; Alanine; Antiviral Agents; Child; COVID-19; COVID-19 Drug Treatment; Humans; Infant; Infant, Newborn; SARS-CoV-2 | 2023 |
Reduced risk of death in people with SARS-CoV-2 infection treated with remdesivir: a nested case-control study.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Case-Control Studies; COVID-19 Drug Treatment; Heparin; Humans; Retrospective Studies; SARS-CoV-2 | 2022 |
[Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir].
Topics: Adenosine Monophosphate; Alanine; Amiodarone; Anticoagulants; Atorvastatin; Bisoprolol; COVID-19 Drug Treatment; Dexamethasone; Diltiazem; Drug Interactions; Humans; International Normalized Ratio; Male; Middle Aged; Warfarin | 2022 |
Prognostic factors of 30-day mortality in patients with COVID-19 pneumonia under standard remdesivir and dexamethasone treatment.
Topics: Adenosine Monophosphate; Aged; Alanine; Anti-Bacterial Agents; C-Reactive Protein; COVID-19 Drug Treatment; Dexamethasone; Dyspnea; Humans; Lactate Dehydrogenases; Pneumonia; Prognosis; Retrospective Studies; SARS-CoV-2 | 2022 |
Remdesivir-Induced Pancreatitis in a Patient With Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Pancreatitis | 2022 |
1'-Cyano Intermediate Enables Rapid and Stereoretentive Access to 1'-Modified Remdesivir Nucleosides.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Nucleosides; SARS-CoV-2 | 2022 |
Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity.
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Cryoelectron Microscopy; Humans; Molecular Docking Simulation; Nucleosides; Polyphosphates; Pyrazines; Reproduction; Ribonucleosides; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2 | 2022 |
Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short report.
Topics: Adenosine Monophosphate; Alanine; Animals; Child, Preschool; COVID-19; DNA Copy Number Variations; DNA-Directed RNA Polymerases; DNA, Mitochondrial; Humans; Male; Mammals; Mitochondria; Nucleosides; Rats; RNA, Viral; SARS-CoV-2; Sequence Deletion | 2022 |
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Hepacivirus; Hepatitis C; Humans; Lung; Nucleosides; SARS-CoV-2; Sofosbuvir | 2022 |
Synergistic drug combinations designed to fully suppress SARS-CoV-2 in the lung of COVID-19 patients.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lung; SARS-CoV-2 | 2022 |
Dual effects of NV-CoV-2 biomimetic polymer: An antiviral regimen against COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Biomimetics; Body Weight; COVID-19; COVID-19 Drug Treatment; Humans; Rats; SARS-CoV-2 | 2022 |
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Filoviridae; Hemorrhagic Fever, Ebola; Humans; Zika Virus; Zika Virus Infection | 2023 |
Remdesivir saves lives. Were 3 years needed to learn that?
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; Humans; SARS-CoV-2 | 2023 |
Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Adult; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Respiratory Insufficiency | 2023 |
Multistep Synthesis of Analogues of Remdesivir: Incorporating Heterocycles at the C-1' Position.
Topics: Adenosine Monophosphate; Alanine; Nucleotides; Oxadiazoles | 2023 |
Late remdesivir treatment initiation partially protects African green monkeys from lethal Nipah virus infection.
Topics: Adenosine Monophosphate; Alanine; Animals; Brain; Chlorocebus aethiops; Henipavirus Infections; Nipah Virus | 2023 |