alanine and GS-441524

alanine has been researched along with GS-441524 in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	27 (100.00)	2.80

Authors

Authors	Studies
Alvarez, JC; Annane, D; Etting, I; Larabi, IA; Moine, P	1
Bunel, V; Descamps, D; Jaquet, P; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH	1
Bunel, V; Descamps, D; Jaquet, P; Le Beller, C; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH	1
Muller, FL; Yan, VC	1
Cies, JJ; Davis, MR; Pham, CU	1
Arnold, L; Chernobrovkin, A; Friman, T; Martinez Molina, D	1
Chen, YS; Chu, J; German, P; Humeniuk, R; John Ling, KH; Mathias, A; Tarnowski, T; van Ingen, E; Xiao, D	1
Brügel, M; Habler, K; Liebchen, U; Paal, M; Scharf, C; Schönermarck, U; Teupser, D; Vogeser, M	1
Bojkova, D; Buyck, C; Ciesek, S; Cinatl, J; De Jonghe, S; De Meyer, S; Jochmans, D; Leyssen, P; Neyts, J; Van Damme, E; Van Loock, M	1
Babusis, D; Cao, H; German, P; Humeniuk, R; Kirby, BJ; Ling, J; Lutz, JD; Mathias, A; Osinusi, A; Porter, D; Reddy, YS; Wei, X	1
Gandhi, M; Gerona, R; Metcalfe, J; Ong, CM; Reckers, A; Wu, AHB	1
Daftarian, PM; George, MV; Kleiman, E; Magcase, D; Mao, B; Sierra, G	1
Abe, T; Maekawa, M; Mano, N; Sato, T; Yamaguchi, H	1
Deb, S; Reeves, AA	1
Bode-Böger, SM; Hoeper, MM; Kielstein, JT; Martens-Lobenhoffer, J; Schmidt, JJ	1
Beadle, JR; Carlin, AF; Clark, AE; Garretson, AF; Hostetler, KY; Leibel, SL; McMillan, RE; McVicar, RN; Murphy, J; Schooley, RT; Smith, VI; Valiaeva, N; Xie, J; Zhang, XQ	1
Hansen, PE; Hansen, PR; Jürgens, G; Rasmussen, HB; Taboureau, O; Thomsen, R; Zeth, K	1
Cho, JY; Choe, PG; Han, SS; Jeong, SI; Kang, CK; Kim, DK; Kim, NJ; Lee, S; Lee, SM; Oh, MD; Park, WB; Yang, L	1
Hamada, S; Hirai, T; Imoto, E; Ito, I; Itohara, K; Kai, S; Katada, Y; Matsumura, K; Nakagawa, T; Ohtsuru, S; Sato, Y; Sukeishi, A; Tanabe, N; Terada, T; Yanagita, M; Yonezawa, A	1
Green, DJ; Imburgia, CE; Kelley, WE; Mcknite, AM; Reilly, CA; Rower, JE; Watt, KM	1
Beadle, JR; Chatterjee, P; Flint, M; Hostetler, KY; Lo, MK; Montgomery, JM; Murphy, J; Schooley, RT; Shrivastava-Ranjan, P; Spiropoulou, CF; Valiaeva, N	1
Aukland, MH; Brunen, S; Grossmann, O; Leutzsch, M; List, B; Mitschke, B; Obradors, C; Schwengers, SA	1
Defant, A; Dosi, F; Innocenti, N; Mancini, I	1
André, E; Chiu, W; De Jonghe, S; Jochmans, D; Leyssen, P; Maes, P; Neyts, J; Raymenants, J; Slechten, B; Vangeel, L	1
Bilello, JP; Camus, G; Cihlar, T; Du Pont, V; Kurhade, C; Li, J; Lu, X; Maiorova, E; Manhas, S; Martin, R; Mo, H; Perry, JK; Pitts, J; Porter, DP; Riola, N; Rodriguez, L; Shi, PY; Xie, X	1
Bosma, LBE; Leegwater, E; Moes, DJAR; Ottens, TH; van der Meer, IM; van Nieuwkoop, C; Wilms, EB	1
Agrati, C; Ascoli Bartoli, T; Benvenuto, D; Marchioni, L; Nicastri, E; Stazi, GV; Tempestilli, M	1

Reviews

2 review(s) available for alanine and GS-441524

Article	Year
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor. Clinical pharmacokinetics, 2021, Volume: 60, Issue:5 Topics: Adenosine; Adenosine Monophosphate; Adult; Alanine; Animals; Antiviral Agents; Area Under Curve; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Drug Interactions; Furans; Half-Life; Humans; Metabolic Clearance Rate; Pyrroles; SARS-CoV-2; Triazines	2021
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19. Viruses, 2021, 07-14, Volume: 13, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Humans; Phosphorylation; Prodrugs; SARS-CoV-2	2021

Article

Year

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor.

Clinical pharmacokinetics, 2021, Volume: 60, Issue:5

Topics: Adenosine; Adenosine Monophosphate; Adult; Alanine; Animals; Antiviral Agents; Area Under Curve; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Drug Interactions; Furans; Half-Life; Humans; Metabolic Clearance Rate; Pyrroles; SARS-CoV-2; Triazines

2021

Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19.

Viruses, 2021, 07-14, Volume: 13, Issue:7

Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Humans; Phosphorylation; Prodrugs; SARS-CoV-2

2021

Other Studies

25 other study(ies) available for alanine and GS-441524

Article	Year
Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient. Clinical chemistry and laboratory medicine, 2020, 08-27, Volume: 58, Issue:9 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chromatography, Liquid; Coronavirus Infections; COVID-19; Drug Monitoring; Drug Stability; Female; Furans; Humans; Limit of Detection; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pyrroles; Reproducibility of Results; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2020
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19. Antimicrobial agents and chemotherapy, 2020, 10-20, Volume: 64, Issue:11 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; beta-Cyclodextrins; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Interactions; Furans; Humans; Intensive Care Units; Lung Transplantation; Multiple Organ Failure; Pandemics; Pneumonia, Viral; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity". Antimicrobial agents and chemotherapy, 2020, 11-17, Volume: 64, Issue:12 Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung Transplantation; Neuroglia; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity. Antimicrobial agents and chemotherapy, 2020, 11-17, Volume: 64, Issue:12 Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on haemodialysis. The Journal of antimicrobial chemotherapy, 2021, 02-11, Volume: 76, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Furans; Humans; Kidney Failure, Chronic; Pyrroles; Renal Dialysis; Triazines	2021
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target. SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; ATPases Associated with Diverse Cellular Activities; Cell Cycle Proteins; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; Furans; Hep G2 Cells; Humans; Mass Spectrometry; Proteomics; Pyrroles; Triazines; United States; United States Food and Drug Administration	2021
Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies. Analytical biochemistry, 2021, 03-15, Volume: 617 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, High Pressure Liquid; COVID-19 Drug Treatment; Drug Monitoring; Furans; Humans; Limit of Detection; Pyrroles; Tandem Mass Spectrometry; Triazines	2021
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum Journal of pharmaceutical and biomedical analysis, 2021, Mar-20, Volume: 196 Topics: Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Chloroquine; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Furans; Humans; Hydroxychloroquine; Isotopes; Lopinavir; Pandemics; Pyrazines; Pyrroles; Ritonavir; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2021
In vitro activity of itraconazole against SARS-CoV-2. Journal of medical virology, 2021, Volume: 93, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Repositioning; Furans; Humans; Itraconazole; Pyrroles; SARS-CoV-2; Triazines; Vero Cells; Virus Replication	2021
A combined assay for quantifying remdesivir and its metabolite, along with dexamethasone, in serum. The Journal of antimicrobial chemotherapy, 2021, 06-18, Volume: 76, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, Liquid; COVID-19 Drug Treatment; Dexamethasone; Furans; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2021
Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells. Scientific reports, 2021, 05-05, Volume: 11, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Alanine; CD8-Positive T-Lymphocytes; Cell Proliferation; Humans; Immunologic Memory; T-Lymphocytes	2021
Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2021, Volume: 24 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Dogs; Dose-Response Relationship, Drug; Drug Approval; Furans; Humans; Kidney; Kidney Tubules, Proximal; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Pyrroles; Triazines	2021
Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2021, Volume: 24 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Computer Simulation; COVID-19; COVID-19 Drug Treatment; Databases, Chemical; Drug Interactions; Furans; Humans; Prodrugs; Pyrroles; Risk Assessment; Risk Factors; SARS-CoV-2; Triazines	2021
Pharmacokinetics of Remdesivir and GS-441524 during PIRRT and Seraph 100 Therapy. Clinical journal of the American Society of Nephrology : CJASN, 2021, Volume: 16, Issue:8 Topics: Adenosine; Adenosine Monophosphate; Adult; Aged; Alanine; COVID-19 Drug Treatment; Female; Hemofiltration; Humans; Intermittent Renal Replacement Therapy; Male; SARS-CoV-2	2021
Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs. Antimicrobial agents and chemotherapy, 2021, 09-17, Volume: 65, Issue:10 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; COVID-19 Drug Treatment; Cricetinae; Humans; Lipids; Prodrugs; SARS-CoV-2	2021
Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series. Clinical and translational science, 2022, Volume: 15, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Humans; Kidney; Renal Replacement Therapy	2022
Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction. CPT: pharmacometrics & systems pharmacology, 2022, Volume: 11, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Body Surface Area; COVID-19; COVID-19 Drug Treatment; Drug Administration Schedule; Extracorporeal Membrane Oxygenation; Female; Glomerular Filtration Rate; Humans; Japan; Kidney Diseases; Male; Middle Aged; Monte Carlo Method; Precision Medicine; Retrospective Studies	2022
Remdesivir and GS-441524 Extraction by Ex Vivo Extracorporeal Life Support Circuits. ASAIO journal (American Society for Artificial Internal Organs : 1992), 2022, 09-01, Volume: 68, Issue:9 Topics: Adenosine; Adenosine Monophosphate; Alanine; COVID-19; COVID-19 Drug Treatment; Extracorporeal Membrane Oxygenation; Humans; Renal Replacement Therapy	2022
Broad-Spectrum Microbiology spectrum, 2021, 12-22, Volume: 9, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; COVID-19 Drug Treatment; Glyceryl Ethers; Humans; Lipids; Nucleosides; Prodrugs; SARS-CoV-2	2021
Direct and Catalytic C-Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside. Angewandte Chemie (International ed. in English), 2022, 03-07, Volume: 61, Issue:11 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Catalysis; Chemistry Techniques, Synthetic; COVID-19 Drug Treatment; Cyclization; Glycosylation; Humans; Models, Molecular; Nucleosides; Stereoisomerism; Time Factors	2022
Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibitors. International journal of molecular sciences, 2022, Jan-04, Volume: 23, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Cellulose; Computational Biology; Coronavirus RNA-Dependent RNA Polymerase; Molecular Docking Simulation; Molecular Dynamics Simulation; Nucleosides; Pyrolysis; SARS-CoV-2	2022
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern. Antiviral research, 2022, Volume: 198 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Microbial Sensitivity Tests; Nitriles; Proline; RNA-Dependent RNA Polymerase; SARS-CoV-2; Vero Cells; Virus Replication	2022
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants. Antimicrobial agents and chemotherapy, 2022, 06-21, Volume: 66, Issue:6 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; SARS-CoV-2	2022
Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients. Antimicrobial agents and chemotherapy, 2022, 06-21, Volume: 66, Issue:6 Topics: Adenosine; Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; COVID-19 Drug Treatment; Critical Illness; Furans; Humans; Monte Carlo Method; Triazines	2022
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjects. The Journal of antimicrobial chemotherapy, 2022, 09-30, Volume: 77, Issue:10 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Transaminases; Triazines	2022