alamethicin has been researched along with tsushimycin* in 2 studies
1 review(s) available for alamethicin and tsushimycin
| Article | Year |
|---|---|
Antimicrobial peptide killing of African trypanosomes.
The diseases caused by trypanosomes are medically and economically devastating to the population of Sub-Saharan Africa. Parasites of the genus Trypanosoma infect both humans, causing African sleeping sickness, and livestock, causing Nagana. The development of effective treatment strategies has suffered from severe side effects of approved drugs, resistance and major difficulties in delivering drugs. Antimicrobial peptides (AMPs) are ubiquitous components of immune defence and are being rigorously pursued as novel sources of new therapeutics for a variety of pathogens. Here, we review the role of AMPs in the innate immune response of the tsetse fly to African trypanosomes, catalogue trypanocidal AMPs from diverse organisms and highlight the susceptibility of bloodstream form African trypanosomes to killing by unconventional toxic peptides. Topics: Alamethicin; Animals; Antimicrobial Cationic Peptides; Cell Membrane; Cell Membrane Permeability; Humans; Lipopeptides; Peptides; Peptides, Cyclic; Trypanocidal Agents; Trypanosoma; Tsetse Flies | 2011 |
1 other study(ies) available for alamethicin and tsushimycin
| Article | Year |
|---|---|
In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin.
In the course of our screening for antitrypanosomal compounds from soil microorganisms, as well as from the antibiotics library of the Kitasato Institute for Life Sciences, we found three peptide antibiotics, leucinostatin (A and B), alamethicin I and tsushimycin, which exhibited potent or moderate antitrypanosomal activity. We report here the in vitro and in vivo antitrypanosomal properties and cytotoxicities of leucinostatin A and B, alamethicin I and tsushimycin compared with suramin. We also discuss their possible mode of action. This is the first report of in vitro and in vivo trypanocidal activity of leucinostatin A and B, alamethicin I and tsushimycin. Topics: Alamethicin; Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cell Line; Cell Survival; Female; Fermentation; Lipopeptides; Mice; Mice, Inbred ICR; Paecilomyces; Peptides; Peptides, Cyclic; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |