Compounds > aklavinone
Page last updated: 2024-09-04

aklavinone and aclarubicin

aklavinone has been researched along with aclarubicin in 9 studies

Compound Research Comparison

Studies
(aklavinone)		Trials
(aklavinone)		Recent Studies (post-2010)
(aklavinone)		Studies
(aclarubicin)		Trials
(aclarubicin)		Recent Studies (post-2010) (aclarubicin)
240282697105

Protein Interaction Comparison

ProteinTaxonomyaklavinone (IC50)aclarubicin (IC50)
72 kDa type IV collagenaseHomo sapiens (human)9.9
5-hydroxytryptamine receptor 2BHomo sapiens (human)1.106

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's3 (33.33)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matsuzawa, Y; Oki, T; Takeuchi, T; Umezawa, H; Yoshimoto, A1
Kitamura, I; Naganawa, H; Oki, T; Takeuchi, T; Tobe, H; Umezawa, H; Yoshimoto, A1
Hakala, J; Lundell, J; Mäntsälä, P; Niemi, J; Ylihonko, K1
Demant, EJ; Friche, E; Hansen, HH; Jensen, PB; Kjeldsen, E; Sehested, M; Sørensen, BS1
Bartoshevich, IuE; Efremenkova, OV; Makhova, EV; Vasil'eva, SV1
Mäntsälä, P; Niemi, J; Wang, Y1
Hakala, J; Hautala, A; Kantola, J; Mäntsälä, P; Räty, K; Ylihonko, K1
Kahne, D; Leimkuhler, C; Lu, W; Oberthür, M; Walsh, CT1
Gatto, GJ; Kahne, D; Kruger, RG; Leimkuhler, C; Lu, W; Oberthür, M; Walsh, CT1

Other Studies

9 other study(ies) available for aklavinone and aclarubicin

ArticleYear
Biosynthesis of anthracycline antibiotics by Streptomyces galilaeus. I. Glycosidation of various anthracyclinones by an aclacinomycin-negative mutant and biosynthesis of aclacinomycins from aklavinone.
    The Journal of antibiotics, 1980, Volume: 33, Issue:11

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Glycosides; Mutation; Naphthacenes; Streptomyces

1980
Biosynthesis of aklavinone and aclacinomycins.
    The Journal of antibiotics, 1981, Volume: 34, Issue:11

    Topics: Aclarubicin; Anti-Bacterial Agents; Naphthacenes; Streptomyces

1981
Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants.
    Microbiology (Reading, England), 1994, Volume: 140 ( Pt 6)

    Topics: Acetates; Aclarubicin; Anthraquinones; Carbohydrate Sequence; Carbohydrates; Molecular Sequence Data; Molecular Structure; Mutagenesis; Naphthacenes; Propionates; Streptomyces

1994
Different modes of anthracycline interaction with topoisomerase II. Separate structures critical for DNA-cleavage, and for overcoming topoisomerase II-related drug resistance.
    Biochemical pharmacology, 1993, May-25, Volume: 45, Issue:10

    Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; Carcinoma, Small Cell; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Lung Neoplasms; Mice; Naphthacenes; Stimulation, Chemical; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1993
[Genotoxic and mutagenic activity of antineoplastic anthracyclines and their aglycones: study in two test-systems].
    Genetika, 1996, Volume: 32, Issue:2

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Carubicin; Daunorubicin; Doxorubicin; Intercalating Agents; Mutagenicity Tests; Mutagens; Naphthacenes; Nucleic Acid Conformation; Salmonella typhimurium; SOS Response, Genetics; Structure-Activity Relationship

1996
Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.
    FEMS microbiology letters, 2002, Feb-19, Volume: 208, Issue:1

    Topics: Aclarubicin; Anthracyclines; Antibiotics, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Bacterial Proteins; Carboxylic Ester Hydrolases; Mixed Function Oxygenases; Mutation; Naphthacenes; Streptomyces; Substrate Specificity

2002
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
    Gene, 2002, Jun-26, Volume: 293, Issue:1-2

    Topics: Aclarubicin; Cloning, Molecular; DNA, Bacterial; Genes, Bacterial; Genetic Complementation Test; Multienzyme Complexes; Multigene Family; Mutation; Naphthacenes; Plasmids; Sequence Analysis, DNA; Streptomyces

2002
AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.
    Biochemistry, 2004, Apr-20, Volume: 43, Issue:15

    Topics: Aclarubicin; Catalysis; Cloning, Molecular; Fucose; Fucosyltransferases; Glycosylation; Hexosamines; Naphthacenes; Streptomyces; Substrate Specificity; Thymine Nucleotides; Trisaccharides

2004
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
    Chemistry & biology, 2005, Volume: 12, Issue:5

    Topics: Aclarubicin; Anthracyclines; Bacterial Proteins; Disaccharides; Escherichia coli; Genetic Vectors; Glycosides; Glycosylation; Glycosyltransferases; Naphthacenes; Nucleoside Diphosphate Sugars; Protein Binding; Streptomyces

2005