Page last updated: 2024-09-03

ak 2123 and triazoles

ak 2123 has been researched along with triazoles in 35 studies

Compound Research Comparison

Studies (ak 2123)	Trials (ak 2123)	Recent Studies (post-2010) (ak 2123)	Studies (triazoles)	Trials (triazoles)	Recent Studies (post-2010) (triazoles)
52	8	5	25,808	2,252	13,501

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	14 (40.00)	18.2507
2000's	16 (45.71)	29.6817
2010's	5 (14.29)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
García-Angulo, AH; Kagiya, VT	1
Diatchkovskaya, RF; Kagiya, TV; Konovalova, NP; Volkova, LM	1
Hua, BY; Huan, LC	1
Hori, Y; Zhou, B	1
Chatterjee, N; Huilgol, NG; Mehta, AR	1
Devi, PU; Rao, BS	1
Kagiya, TV; Kunugita, N; Mei, N; Norimura, T	1
Iakushchenko, TN; Kagiia, T; Konovalova, NP; Kotel'nikova, RA; Tat'ianenko, LV; Volkova, LM	1
Kagiya, TV; Konovalova, NP; Kotelnikova, RA; Tatyanenko, LV; Volkova, LM; Yakushchenko, TN	1
Shchepetkin, IA	1
Shibamoto, Y	1
Schepetkin, IA	1
Afanasjev, S; Antipov, S; Cherdyntseva, N; Schepetkin, I; Zyryanov, B	1
Schepetkin, I	1
Goncharova, SA; Kagiia, VT; Konovalova, NP; Raevskaia, TA	1
Kothari, L; Murugesan, S; Nair, CK; Noronha, OP; Samuel, AM; Shetty, SJ; Srivastava, TS	1
Huilgol, NG; Kagiya, TV; Kapoor, S; Mathew, R; Nair, CK	1
Kagiya, TV; Nair, CK; Pasupathy, K	1
Goncharova, SA; Kagiya, TV; Konovalova, NP; Rajewskaya, TA	1
Chatterjee, NA; Das, K; Dobrowsky, W; Huilgol, NG; Kagiya, VT; Tatsuzaki, H	1
Cherdyntseva, NV; Kagiia, VT; Shchepetkin, IA	1
Konovalova, NP	1
Kagiya, TV; Nair, CK; Rajagopalan, R	1
Banerjee, S; Chakraborty, S; Das, T; Kagiya, VT; Mukherjee, A; Nair, CK; Samuel, G; Sarma, HD; Venkatesh, M	1
Cherdyntseva, NV; Choinzonov, EL; Kagiya, TV; Kondakova, IV; Tcheredova, VV; Zagrebelnaya, GV	1
Alam, A; Rapthap, CC; Sharan, RN; Singh, V; Singha, LI	1
Hori, H; Ito, M; Nagasawa, H; Ogino, H; Shibamoto, Y; Sugie, C; Suzuki, H; Uto, Y	1
Dobrowsky, W; Huigol, NG; Jayatilake, RS; Kagiya, VT; Kizilbash, NI; Okkan, S; Tatsuzaki, H	1
Kagiya, TV; Kashiwakura, I; Kondo, T; Nomura, T; Wei, ZL; Yu, DY; Zhao, QL	1
Kondo, T; Shehata, M; Wei, ZL; Yu, DY; Zhao, QL	1
Banerjee, S; Mallia, MB; Mathur, A; Pillai, MR; Sarma, HD	1
Aibe, N; Kagiya, T; Kobayashi, K; Kodani, N; Koizumi, M; Nakamura, S; Tsubokura, T; Yamada, K; Yamazaki, H; Yoshida, K	1
Aibe, N; Kagiya, T; Nakamura, S; Nishimura, T; Okabe, H; Yamazaki, H; Yoshida, K	1
Aibe, N; Kagiya, T; Kimoto, T; Kodani, N; Koizumi, M; Nakamura, S; Nishimura, T; Sihomi, H; Tsubokura, T; Yamazaki, H; Yoshida, K	1
Nair, CK; Sreeja, S	1

Reviews

1 review(s) available for ak 2123 and triazoles

Article	Year
[Contribution of radiation biology to the development of radiation therapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:9 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose Fractionation, Radiation; Humans; Imidazoles; Lung Neoplasms; Neoplasms; Nimorazole; Radiation-Sensitizing Agents; Triazoles	1999

Trials

6 trial(s) available for ak 2123 and triazoles

Article	Year
Intratumoral and parametrial infusion of a 3-nitrotriazole (AK-2123) in the radiotherapy of the uterine cervix cancer: stage II-III--preliminary positive results. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Evaluation; Female; Humans; Radiation-Sensitizing Agents; Triazoles; Uterine Cervical Neoplasms	1992
An overview of the initial experience with AK-2123 as a hypoxic cell sensitizer with radiation in the treatment of advanced head and neck cancers. International journal of radiation oncology, biology, physics, 1996, Mar-15, Volume: 34, Issue:5 Topics: Adult; Aged; Humans; Middle Aged; Neoplasm Staging; Oropharyngeal Neoplasms; Radiation-Sensitizing Agents; Remission Induction; Triazoles	1996
The luminol-amplified chemiluminescence of neutrophils and monocytes in patients with gastric cancer after intraoperative radiotherapy using radiosensitizer sanazole. Cancer biotherapy & radiopharmaceuticals, 1999, Volume: 14, Issue:5 Topics: Adenocarcinoma; Aged; Female; Humans; Intraoperative Period; Luminescent Measurements; Luminol; Lymphoma, Non-Hodgkin; Male; Middle Aged; Monocytes; Neutrophil Activation; Neutrophils; Radiation-Sensitizing Agents; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Triazoles	1999
Sanazole as a sensitizer of hypoxic cells with radical radiation in the treatment of advanced cancer of cervix an Indian experience. Indian journal of cancer, 2002, Volume: 39, Issue:2 Topics: Adult; Aged; Female; Humans; India; Middle Aged; Nervous System Diseases; Radiation-Sensitizing Agents; Radiotherapy Dosage; Survival Rate; Triazoles; Uterine Cervical Neoplasms	2002
AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre randomised trial. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2007, Volume: 82, Issue:1 Topics: Adult; Aged; Brachytherapy; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prospective Studies; Radiation-Sensitizing Agents; Radiotherapy; Survival Analysis; Treatment Outcome; Triazoles; Uterine Cervical Neoplasms	2007
Feasibility trial for daily oral administration of the hypoxic sensitizer AK-2123 (Sanazole) in radiotherapy. Anticancer research, 2013, Volume: 33, Issue:2 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Feasibility Studies; Female; Humans; Male; Middle Aged; Neoplasms; Radiation-Sensitizing Agents; Triazoles	2013

Other Studies

28 other study(ies) available for ak 2123 and triazoles

Article	Year
Radiosensitizer AK-2123 as modulating agent in the chemotherapy of experimental metastases. Neoplasma, 1995, Volume: 42, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Lewis Lung; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Female; Melanoma, Experimental; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Radiation-Sensitizing Agents; Triazoles	1995
Clinical pharmacokinetic study and sensitive effect of AK-2123. International journal of radiation oncology, biology, physics, 1994, Jun-15, Volume: 29, Issue:3 Topics: Adult; Aged; Female; Humans; Lung Neoplasms; Male; Middle Aged; Radiation-Sensitizing Agents; Triazoles	1994
[Modification effects of AK-2123 on adriamycin to mouse leukemic cells]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:10 Topics: Animals; Doxorubicin; Drug Synergism; Leukemia L1210; Mice; Triazoles; Tumor Cells, Cultured	1994
Multimodality treatment using AK-2123, hydralazine, radiation & hyperthermia on a transplantable mouse tumour. The Indian journal of medical research, 1996, Volume: 104 Topics: Animals; Combined Modality Therapy; Female; Hydralazine; Hyperthermia, Induced; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Peritoneal Neoplasms; Radiation-Sensitizing Agents; Sarcoma, Experimental; Triazoles; Vasodilator Agents	1996
Modification of radio-thermo-chemotherapy by AK-2123 and hydralazine in tumor bearing mice. Indian journal of experimental biology, 1996, Volume: 34, Issue:9 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hydralazine; Hyperthermia, Induced; Mice; Mice, Inbred C3H; Radiation-Sensitizing Agents; Triazoles; Tumor Cells, Cultured	1996
[Inhibitory effect of the radiosensitizer AK-2123 on experimental liver metastasis and active transport of calcium ions]. Voprosy onkologii, 1997, Volume: 43, Issue:3 Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Calcium Channel Blockers; Female; Fluorouracil; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Radiation-Sensitizing Agents; Time Factors; Triazoles	1997
Inhibitory effect of radiosensitizer AK-2123 on experimental hepatic metastases and Ca2+ active transport. Neoplasma, 1997, Volume: 44, Issue:6 Topics: Adenocarcinoma; Animals; Biological Transport, Active; Ca(2+) Mg(2+)-ATPase; Calcium; Colonic Neoplasms; Female; Liver Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Radiation-Sensitizing Agents; Triazoles	1997
Generation of sanazole nitro radicals by xanthine oxidase. Biochemistry. Biokhimiia, 1998, Volume: 63, Issue:12 Topics: Animals; Cattle; Nitro Compounds; Oxidation-Reduction; Radiation-Sensitizing Agents; Triazoles; Xanthine Oxidase	1998
Lucigenin luminescence elicited by microsomes and its modulation by nitroazole compounds. IUBMB life, 1999, Volume: 48, Issue:5 Topics: Acridines; Animals; Cattle; Horses; Luminescent Measurements; Male; Metronidazole; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Superoxide Dismutase; Triazoles; Xanthine Oxidase	1999
Suppression by radiosensitizer AK-2123 of early phorbol myristate acetate-stimulated chemiluminescence response of human neutrophils induced by gamma-irradiation (short communication). Cancer biotherapy & radiopharmaceuticals, 1998, Volume: 13, Issue:6 Topics: Dose-Response Relationship, Radiation; Gamma Rays; Humans; In Vitro Techniques; Kinetics; Luminescent Measurements; Neutrophil Activation; Neutrophils; Radiation-Sensitizing Agents; Tetradecanoylphorbol Acetate; Triazoles	1998
[The radiosensitizer AK-2123 enhances sensitivity of MDR-tumors to Mitomycin C]. Voprosy onkologii, 2000, Volume: 46, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Leukemia P388; Mice; Mitomycin; Radiation-Sensitizing Agents; Triazoles	2000
Technetium-99m-cyclam AK 2123: a novel marker for tumor hypoxia. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2001, Volume: 54, Issue:1 Topics: Animals; Cell Hypoxia; Female; Lung Neoplasms; Mammary Neoplasms, Experimental; Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Tissue Distribution; Triazoles	2001
Redox reactions of sanazole (AK-2123) in aqueous solutions: a pulse radiolysis study. Journal of radiation research, 2000, Volume: 41, Issue:4 Topics: Electron Transport; Escherichia coli; Oxidation-Reduction; Pulse Radiolysis; Radiation-Sensitizing Agents; Solutions; Triazoles	2000
Effect of a hypoxic radiosensitizer, AK 2123 (Sanazole), on yeast Saccharomyces cerevisiae. Journal of radiation research, 2001, Volume: 42, Issue:2 Topics: Cell Hypoxia; Radiation-Sensitizing Agents; Saccharomyces cerevisiae; Triazoles	2001
Nitrotriazole AK-2123 enhances mitomycin C activity in mice bearing multidrug-resistant tumors. Journal of chemotherapy (Florence, Italy), 2001, Volume: 13, Issue:6 Topics: Animals; Antibiotics, Antineoplastic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Leukemia P388; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitomycin; Radiation-Sensitizing Agents; Triazoles	2001
[Effect of sanazole and metrinidazole on production of reactive oxygen species by macrophages]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2003, Volume: 48, Issue:3 Topics: Adjuvants, Immunologic; Animals; Anti-Infective Agents; Antineoplastic Agents; In Vitro Techniques; Macrophages; Macrophages, Peritoneal; Metronidazole; Mice; Mice, Inbred BALB C; Radiation-Sensitizing Agents; Reactive Oxygen Species; Spleen; Tetradecanoylphorbol Acetate; Triazoles	2003
Ultralow doses of various drugs in chemotherapy of experimental tumors. Bulletin of experimental biology and medicine, 2003, Volume: 135 Suppl 7 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Indazoles; Leukemia P388; Lung Neoplasms; Melanoma; Mice; Mitomycin; Neoplasm Metastasis; Neoplasms, Experimental; Triazoles; Xenograft Model Antitumor Assays	2003
Radiosensitizer sanazole (AK-2123) enhances gamma-radiation-induced apoptosis in murine fibrosarcoma. Journal of radiation research, 2003, Volume: 44, Issue:4 Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Nucleus; DNA Fragmentation; Fibrosarcoma; Gamma Rays; Genome; Male; Mice; Neoplasm Transplantation; Neoplasms, Radiation-Induced; Nucleosomes; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors; Triazoles	2003
Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia. Bioorganic & medicinal chemistry, 2004, Dec-01, Volume: 12, Issue:23 Topics: Animals; Antineoplastic Agents; Drug Delivery Systems; Fibrosarcoma; Hypoxia; Lutetium; Mice; Neoplasms; Radioisotopes; Radiopharmaceuticals; Tissue Distribution; Triazoles	2004
Production of nitric oxide by hypoxic radiosensitizer sanazole. Experimental oncology, 2004, Volume: 26, Issue:4 Topics: Animals; Cell Hypoxia; Lymphoma; Mastocytoma; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Nitric Oxide; Oxyhemoglobins; Radiation-Sensitizing Agents; Triazoles	2004
Radiomodulatory effect of liposome encapsulated AK-2123 on tumor in mice exposed to hepatocarcinogen. Molecular and cellular biochemistry, 2005, Volume: 271, Issue:1-2 Topics: Acetylcholinesterase; Animals; Carcinogens; Combined Modality Therapy; Diethylnitrosamine; DNA; Gamma Rays; gamma-Glutamyltransferase; Liposomes; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Radiation-Sensitizing Agents; RNA; Triazoles; Whole-Body Irradiation	2005
Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo. Journal of radiation research, 2005, Volume: 46, Issue:4 Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Female; Mice; Nimorazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Treatment Outcome; Triazoles	2005
Enhancement of radiation-induced apoptosis of human lymphoma U937 cells by sanazole. Apoptosis : an international journal on programmed cell death, 2009, Volume: 14, Issue:5 Topics: Apoptosis; Apoptosis Regulatory Proteins; Calcium Signaling; Caspases; DNA Fragmentation; Drug Screening Assays, Antitumor; Exocytosis; fas Receptor; Humans; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Radiation-Sensitizing Agents; Radiation, Ionizing; Reactive Oxygen Species; Triazoles; U937 Cells	2009
Enhancement of hyperthermia-induced apoptosis by sanazole in human lymphoma U937 cells. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2009, Volume: 25, Issue:5 Topics: Apoptosis; Calcium Signaling; Caspases; Humans; Hyperthermia, Induced; Oxidative Stress; Reactive Oxygen Species; Triazoles; U937 Cells	2009
Preparation and evaluation of a ⁹⁹mTcN-PNP complex of sanazole analogue for detecting tumor hypoxia. Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5 Topics: Animals; Cell Hypoxia; Fibrosarcoma; Mice; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Triazoles	2013
Intensity-modulated radiation therapy with hypoxic sensitizer AK-2123 (sanazole) for glioblastoma multiforme using simultaneous integrated boost technique. Anticancer research, 2013, Volume: 33, Issue:4 Topics: Brain Neoplasms; Chemoradiotherapy; Female; Glioblastoma; Humans; Hypoxia; Middle Aged; Prognosis; Radiation-Sensitizing Agents; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Triazoles	2013
Hypofractionated stereotactic radiotherapy with the hypoxic sensitizer AK-2123 (sanazole) for reirradiation of brain metastases: a preliminary feasibility report. Anticancer research, 2013, Volume: 33, Issue:4 Topics: Administration, Oral; Adult; Aged; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dose Fractionation, Radiation; Feasibility Studies; Female; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Radiation-Sensitizing Agents; Radiosurgery; Triazoles	2013
Anticancer Property of Iron Oxide Nanoparticle-Drug Complexes: An In Vitro Study. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2015, Volume: 34, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Berberine; Cell Line, Tumor; Comet Assay; DNA Damage; Drug Screening Assays, Antitumor; Ferric Compounds; Gene Expression Regulation, Neoplastic; Metal Nanoparticles; Mice; Triazoles	2015