Page last updated: 2024-09-05

ajugarin i and chloroquine

ajugarin i has been researched along with chloroquine in 2 studies

*Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. [MeSH]

*Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. [MeSH]

Compound Research Comparison

Studies
(ajugarin i)
Trials
(ajugarin i)
Recent Studies (post-2010)
(ajugarin i)
Studies
(chloroquine)
Trials
(chloroquine)
Recent Studies (post-2010) (chloroquine)
60216,4057634,029

Protein Interaction Comparison

ProteinTaxonomyajugarin i (IC50)chloroquine (IC50)
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium berghei43
Spike glycoproteinBetacoronavirus England 15.47
Replicase polyprotein 1abBetacoronavirus England 15.47
Transmembrane protease serine 2Homo sapiens (human)5.47
Dihydrofolate reductase Bos taurus (cattle)0.0301
Amyloid-beta precursor proteinHomo sapiens (human)7
Histidine-rich protein PFHRP-IIPlasmodium falciparum (malaria parasite P. falciparum)0.2383
Procathepsin LHomo sapiens (human)5.47
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus5.47
Replicase polyprotein 1abHuman coronavirus 229E5.47
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus5.47
Spike glycoproteinSevere acute respiratory syndrome coronavirus 23.58
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 26.375
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)1.5
Serine/threonine-protein kinase mTORHomo sapiens (human)0.27
Beta-secretase 1Homo sapiens (human)7
Spike glycoproteinSevere acute respiratory syndrome-related coronavirus5.47
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.503
Angiotensin-converting enzyme 2 Homo sapiens (human)6.235
Cysteine proteinase falcipain 2a Plasmodium falciparum (malaria parasite P. falciparum)0.02
Cysteine proteinase falcipain 2a Plasmodium falciparum (malaria parasite P. falciparum)0.2

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Busson, R; Chepkwony, H; De Witte, P; Govaerts, C; Hoogmartens, J; Hoornaert, G; Janssens, L; Kuria, KA; Laekeman, G; Maes, L; Quirynen, L; Roets, E; Zupko, I1
Cocquyt, K; Cos, P; Herdewijn, P; Laekeman, G; Maes, L; Van den Steen, PE1

Reviews

1 review(s) available for ajugarin i and chloroquine

ArticleYear
Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Nov-15, Volume: 18, Issue:14

    Topics: Ajuga; Antimalarials; Artemisinins; Chloroquine; Dehydroepiandrosterone Sulfate; Diterpenes; Ergosterol; Ethnopharmacology; Lactones; Malaria; Molecular Structure; Phytosterols; Plant Preparations; Plasmodium; Species Specificity

2011

Other Studies

1 other study(ies) available for ajugarin i and chloroquine

ArticleYear
The antiplasmodial activity of isolates from Ajuga remota.
    Journal of natural products, 2002, Volume: 65, Issue:5

    Topics: Animals; Antimalarials; Antineoplastic Agents; Chloroquine; Chromatography, Thin Layer; Diterpenes; Drug Resistance, Microbial; Drug Screening Assays, Antitumor; Ergosterol; Fluorouracil; Humans; In Vitro Techniques; Inhibitory Concentration 50; Kenya; L-Lactate Dehydrogenase; Lamiaceae; Plants, Medicinal; Plasmodium falciparum; Skin Neoplasms; Tumor Cells, Cultured

2002