Compounds > aj 76

Page last updated: 2024-09-03

aj 76 and 8-hydroxy-2-(di-n-propylamino)tetralin

aj 76 has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 16 studies

Compound Research Comparison

Studies (aj 76)	Trials (aj 76)	Recent Studies (post-2010) (aj 76)	Studies (8-hydroxy-2-(di-n-propylamino)tetralin)	Trials (8-hydroxy-2-(di-n-propylamino)tetralin)	Recent Studies (post-2010) (8-hydroxy-2-(di-n-propylamino)tetralin)
37	0	2	3,530	7	389

Protein Interaction Comparison

Protein	Taxonomy	aj 76 (IC50)	8-hydroxy-2-(di-n-propylamino)tetralin (IC50)
5-hydroxytryptamine receptor 1A	Homo sapiens (human)		0.0012
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)		0.0032
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)		0.81
D(2) dopamine receptor	Bos taurus (cattle)		0.8
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)		0.81
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)		0.81
D(2) dopamine receptor	Rattus norvegicus (Norway rat)		2.8959
Lysosomal alpha-glucosidase	Bos taurus (cattle)		0.0021

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (31.25)	18.7374
1990's	10 (62.50)	18.2507
2000's	1 (6.25)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carlsson, A; Hoffmann, WE; Ljung, E; Lum, JT; Piercey, MF; Svensson, K	1
Callahan, PM; Cunningham, KA; Piercey, MF	1
Carlsson, A; Carlsson, M; Svensson, A	1
Lum, JT; Piercey, MF	1
Carlsson, A; Johansson, AM; Magnusson, T; Svensson, K	1
Carlsson, A; Hajos, M; Hjorth, S; Svensson, K	1
Alföldi, P; Carlsson, A; Hajós, M; Johansson, AM; Obál, F; Rubicsek, G; Svensson, K	1
Carlsson, M; Clark, D; Eriksson, E; Nilsson, C; Svensson, K	1
Carlsson, A; Carlsson, M; Eriksson, E; Hjorth, S; Johansson, AM; Svensson, K	1
Aretha, CW; Galloway, MP; Sinha, A	1
Gaĭnetdinov, RR; Grekhova, TV; Raevskiĭ, KS; Sotnikova, TD	1
Gifford, AN; Johnson, KM	1
Carlsson, A; Hansson, L; Löfberg, L; Waters, N	1
Carlsson, A; Lagerkvist, S; Löfberg, L; Piercey, M; Waters, N	1
Hoffmann, WE; Hyslop, DK; Piercey, MF	1
Gainetdinov, RR; Grekhova, TV; Rayevsky, KS; Sotnikova, TD	1

Other Studies

16 other study(ies) available for aj 76 and 8-hydroxy-2-(di-n-propylamino)tetralin

Article	Year
Antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-AJ76 and (+)-UH232. Brain research, 1992, Aug-21, Volume: 588, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain Chemistry; Cocaine; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Electrophysiology; Homovanillic Acid; Male; Microelectrodes; Motor Activity; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes	1992
Effects of the putative dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 on the discriminative stimulus properties of cocaine. Psychopharmacology, 1992, Volume: 107, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cocaine; Discrimination, Psychological; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes	1992
Synergistic interactions between the NMDA antagonist dizocilpine and the preferential dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 with regard to locomotor stimulation in monoamine-depleted mice. Journal of neural transmission. General section, 1991, Volume: 85, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dizocilpine Maleate; Dopamine Antagonists; Drug Synergism; Locomotion; Male; Mice; Motor Activity; N-Methylaspartate; Tetrahydronaphthalenes	1991
Electrophysiological effects of dopamine autoreceptor antagonists, (+)-AJ 76 and (+)-UH 232. European journal of pharmacology, 1990, Jul-03, Volume: 182, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Animals; Apomorphine; Dendrites; Dopamine; Dopamine Antagonists; Electrophysiology; Feedback; Haloperidol; In Vitro Techniques; Male; Naphthalenes; Neurons; Rats; Rats, Inbred Strains; Substantia Nigra; Tetrahydronaphthalenes	1990
(+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 334, Issue:3 Topics: 4-Butyrolactone; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Brain; Male; Methyltyrosines; Motor Activity; Naphthalenes; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Tetrahydronaphthalenes	1986
In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion. Experimental brain research, 1988, Volume: 70, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Functional Laterality; Hydroxydopamines; Male; Naphthalenes; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Tetrahydronaphthalenes	1988
Dopamine autoreceptor antagonists: effects on sleep-wake activity in the rat. Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electroencephalography; Male; Motor Activity; Naphthalenes; Rats; Receptors, Dopamine; Sleep; Tetrahydronaphthalenes	1987
Compounds with selectivity for dopamine autoreceptors: effects on prolactin secretion in male and female rats. Clinical neuropharmacology, 1986, Volume: 9 Suppl 4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Azepines; Female; Male; Phenanthrenes; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes	1986
The putatively selective dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 stimulate prolactin release in rats. European journal of pharmacology, 1986, Nov-04, Volume: 130, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Azepines; Male; Naphthalenes; Prolactin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Tetrahydronaphthalenes	1986
Dopamine D3-preferring ligands act at synthesis modulating autoreceptors. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Dopamine; Ligands; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes	1995
[Regulation of liberation and metabolism of dopamine in the dorsal striatum of free-living rats: the role of D2- and D3-dopamine autoreceptors]. Doklady Akademii nauk, 1994, Volume: 337, Issue:6 Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Homovanillic Acid; Microdialysis; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes	1994
A pharmacological analysis of the effects of (+)-AJ 76 and (+)-UH 232 at release regulating pre- and postsynaptic dopamine receptors. European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Binding, Competitive; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; In Vitro Techniques; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Tetrahydronaphthalenes	1993
Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo. European journal of pharmacology, 1994, Jan-14, Volume: 251, Issue:2-3 Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Corpus Striatum; Dialysis; Dopamine; Dopamine Antagonists; Drug Administration Routes; Homovanillic Acid; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Salicylamides; Tetrahydronaphthalenes	1994
The dopamine D3 receptor and autoreceptor preferring antagonists (+)-AJ76 and (+)-UH232; a microdialysis study. European journal of pharmacology, 1993, Sep-28, Volume: 242, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Corpus Striatum; Dopamine; Dopamine Antagonists; Haloperidol; Male; Microdialysis; Neurons; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Salicylamides; Substantia Nigra; Tetrahydronaphthalenes; Ventral Tegmental Area	1993
Excitation of type II anterior caudate neurons by stimulation of dopamine D3 receptors. Brain research, 1997, Jul-11, Volume: 762, Issue:1-2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminoquinolines; Animals; Benzothiazoles; Caudate Nucleus; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Imidazoles; Neurons; Pramipexole; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Tetrahydronaphthalenes; Thiazoles	1997
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study). Pharmacological research, 2001, Volume: 43, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes	2001