aj-3941 has been researched along with n-hexane* in 1 studies
1 other study(ies) available for aj-3941 and n-hexane
Article | Year |
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Determination of AJ-3941, a possible agent for the treatment of cerebrovascular disorders, in plasma and brain by means of high-performance liquid chromatography with fluorescence detection.
A sensitive and selective high-performance liquid chromatographic method with fluorescence detection is described for the determination of AJ-3941 (I), a possible agent for the treatment of cerebrovascular disorders, in plasma and brain tissue. A simple hexane extraction was used for plasma, and for brain homogenate the hexane extract was further purified by solid-phase extraction. The determination limit was ca. 3 ng/ml for both plasma (0.5 ml) and 10% (w/v) brain homogenate (1 ml). The method was applied to the determination of I in plasma and brain samples of experimental animals. Topics: Animals; Brain Chemistry; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Dibenzoxepins; Dogs; Hexanes; Mice; Piperazines; Rats | 1992 |