ailanthoidol and homoegonol

2-Aryl/alkylbenzofurans, which constitute an important subclass of naturally occurring lignans and neolignans, have attracted extensive synthetic efforts due to their useful biological activities and significant pharmacological potential. Herein, we report a general and efficient approach to divergent 2-arylbenzofurans through a one-pot synthesis of versatile 2-bromobenzofurans as key intermediates. Using this approach, the first total synthesis of a series of trisubstituted and tetrasubstituted benzofurans bearing the hydroxyethyl unit, including the natural compounds isolated from

Topics: Anisoles; Benzofurans; Cell Line, Tumor; Cell Survival; Cyclization; Drug Screening Assays, Antitumor; Humans; Lavandula; Oxidation-Reduction; Spectrum Analysis