Page last updated: 2024-09-03

ah 6809 and indomethacin

ah 6809 has been researched along with indomethacin in 18 studies

Compound Research Comparison

Studies
(ah 6809)
Trials
(ah 6809)
Recent Studies (post-2010)
(ah 6809)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
16314929,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyah 6809 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (27.78)18.2507
2000's8 (44.44)29.6817
2010's5 (27.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Malinowska, B; Molderings, G; Schlicker, E1
McCann, JD; Smith, JJ; Welsh, MJ1
Akarsu, ES; Ayhan, IH1
Berrino, L; Bräutigam, M; Griepenkerl, I; Jäger, R; Möhlig, A; Racké, K; Reimann, A1
Leff, AR; Mitchell, RW; Ndukwu, IM; White, SR1
Henry, PJ; Knight, DA; Lan, RS; Stewart, GA1
Halm, DR; Halm, ST1
Carmignoto, G; Fellin, T; Gobbo, S; Pozzan, T; Sebelin, A; Zonta, M1
Belvisi, MG; Catley, MC; Clarke, DL; Giembycz, MA; Newton, R; Yacoub, MH1
Brink, C; deMontpreville, V; Gascard, JP; Norel, X; Walch, L1
Bonaventura, D; de Oliveira, AM; Tirapelli, CR2
Kassardjian, A; Kreydiyyeh, SI; Riman, S; Serhan, M1
Carlini, CR; Orchard, I; Stanisçuaski, F; Te Brugge, V1
Henry, PJ; Mann, TS; Taylor, SJ1
de Queiroz, DB; Duarte, GP; Ramos-Alves, FE; Santos-Rocha, J; Xavier, FE1
An, N; Chen, D; Fan, J; Li, J; Liu, C; Luo, J; Su, W; Wang, H; Zhao, J; Zhou, Y1
Arantes, EC; Faccioli, LH; Hori, JI; Paula-Silva, FW; Serezani, CH; Sorgi, CA; Zamboni, DS; Zoccal, KF1

Other Studies

18 other study(ies) available for ah 6809 and indomethacin

ArticleYear
Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype.
    British journal of pharmacology, 1992, Volume: 107, Issue:2

    Topics: Alprostadil; Animals; Dinoprost; Dinoprostone; Electric Stimulation; Indomethacin; Misoprostol; Norepinephrine; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandins; Rats; Receptors, Prostaglandin; Receptors, Prostaglandin E; Vena Cava, Inferior; Xanthenes; Xanthones; Yohimbine

1992
Bradykinin stimulates airway epithelial Cl- secretion via two second messenger pathways.
    The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Calcimycin; Cells, Cultured; Charybdotoxin; Chlorides; Cyclic AMP; Dogs; Epithelium; Indomethacin; Inositol 1,4,5-Trisphosphate; Isoproterenol; Kinetics; Mucous Membrane; Muscle, Smooth; Prostaglandin Antagonists; Quinacrine; Scorpion Venoms; Second Messenger Systems; Thionucleotides; Trachea; Xanthenes; Xanthones

1990
Iloprost, a stable analogue of PGI2, potentiates the hyperthermic effect of PGE2 in rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:2

    Topics: Animals; Body Temperature; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Iloprost; Indomethacin; Injections; Injections, Intraventricular; Male; Preoptic Area; Prostaglandin Antagonists; Rats; Rats, Wistar; Receptors, Prostaglandin E; Xanthenes; Xanthones

1993
Modulation of noradrenaline release in rat isolated stomach by prostanoids, but not by histaminergic mechanisms.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:6

    Topics: Abortifacient Agents, Nonsteroidal; Animals; Dinoprostone; Electric Stimulation; Female; Gastric Mucosa; Histamine Agonists; Indomethacin; Methylhistamines; Misoprostol; Muscarinic Agonists; Norepinephrine; Oxotremorine; Parasympatholytics; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Histamine; Receptors, Prostaglandin; Scopolamine; Stomach; Tetrodotoxin; Xanthenes; Xanthones; Yohimbine

1995
EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 1

    Topics: Acetylcholine; Animals; Biphenyl Compounds; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Electric Stimulation; Epithelium; Guinea Pigs; Iloprost; In Vitro Techniques; Indomethacin; Kinetics; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Prostaglandin Antagonists; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Trachea; Xanthenes; Xanthones

1997
Role of PGE(2) in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea.
    British journal of pharmacology, 2001, Volume: 132, Issue:1

    Topics: Animals; Caenorhabditis elegans Proteins; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; In Vitro Techniques; Indomethacin; Isoenzymes; Ligands; Male; Membrane Proteins; Mice; Mice, Inbred CBA; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Receptor, PAR-2; Receptors, Thrombin; Thrombin; Trachea; Trypsin; Xanthenes; Xanthones

2001
Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 281, Issue:4

    Topics: Animals; Bumetanide; Chlorides; Colon; Cyclooxygenase Inhibitors; Dinoprostone; Diuretics; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Male; Potassium; Prostaglandin Antagonists; Receptors, Prostaglandin; Xanthenes; Xanthones

2001
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.
    The Journal of physiology, 2003, Dec-01, Volume: 553, Issue:Pt 2

    Topics: Animals; Astrocytes; Calcium; Calcium Signaling; Cell Line; Cells, Cultured; Coculture Techniques; Cycloleucine; Cytosol; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Epithelial Cells; Glutamic Acid; Green Fluorescent Proteins; Humans; Indomethacin; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Patch-Clamp Techniques; Prostaglandins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Transfection; Valine; Xanthones

2003
Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.
    British journal of pharmacology, 2004, Volume: 141, Issue:7

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Adenoviridae; Adolescent; Adult; Aged; Alprostadil; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Female; Gene Expression; Genetic Vectors; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Interleukin-1; Isoquinolines; Male; Middle Aged; Misoprostol; Myocytes, Smooth Muscle; Prostaglandins E, Synthetic; Protein Isoforms; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Sulfonamides; Trachea; Xanthones

2004
Prostacyclin release and receptor activation: differential control of human pulmonary venous and arterial tone.
    British journal of pharmacology, 2004, Volume: 142, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Animals; Arachidonic Acid; Blotting, Western; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dose-Response Relationship, Drug; Epoprostenol; Female; France; Humans; Indomethacin; Male; Middle Aged; Muscle, Smooth, Vascular; Nitroarginine; Pulmonary Artery; Pulmonary Veins; Receptors, Prostaglandin; Receptors, Prostaglandin E; Vasoconstriction; Vasodilation; Xanthones

2004
Functional characterization of the mechanisms underlying bradykinin-induced relaxation in the isolated rat carotid artery.
    Life sciences, 2007, Apr-17, Volume: 80, Issue:19

    Topics: Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Imines; In Vitro Techniques; Indazoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptor, Bradykinin B2; Vasodilation; Xanthones

2007
TNF-alpha modulates hepatic Na+-K+ ATPase activity via PGE2 and EP2 receptors.
    Prostaglandins & other lipid mediators, 2007, Volume: 83, Issue:4

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Indomethacin; Liver; Male; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Sodium-Potassium-Exchanging ATPase; Tumor Necrosis Factor-alpha; Xanthones

2007
Chronic methionine load-induced hyperhomocysteinemia impairs the relaxation induced by bradykinin in the isolated rat carotid.
    Amino acids, 2009, Volume: 37, Issue:4

    Topics: Animals; Bradykinin; Cardiovascular Agents; Carotid Arteries; Chronic Disease; Enzyme Inhibitors; Hyperhomocysteinemia; Indazoles; Indomethacin; Male; Methionine; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandin Antagonists; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Vasodilator Agents; Xanthones

2009
Jack bean urease alters serotonin-induced effects on Rhodnius prolixus anterior midgut.
    Journal of insect physiology, 2010, Volume: 56, Issue:9

    Topics: Analysis of Variance; Animals; Canavalia; Cyclic AMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gastrointestinal Tract; Hemolymph; Indomethacin; Muscle Contraction; Plant Proteins; Rhodnius; Second Messenger Systems; Serotonin; Toxins, Biological; Water-Electrolyte Balance; Xanthones

2010
Influence of influenza A infection on capsaicin-induced responses in murine airways.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2

    Topics: Animals; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Capsaicin; Carbachol; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Influenza A virus; Isoproterenol; Leukocytes; Male; Mice; Mice, Inbred BALB C; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Orthomyxoviridae Infections; Piperidines; Prostaglandin Antagonists; Respiratory Mucosa; Specific Pathogen-Free Organisms; Substance P; Trachea; TRPV Cation Channels; Xanthones

2012
Increased cyclooxygenase-2-derived prostanoids contributes to the hyperreactivity to noradrenaline in mesenteric resistance arteries from offspring of diabetic rats.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Dinoprost; Endothelial Cells; Female; Immunoenzyme Techniques; Indomethacin; Male; Mesenteric Arteries; Nitrobenzenes; Norepinephrine; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Sulfonamides; Thromboxane A2; Xanthones

2012
Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury.
    Scientific reports, 2015, Jul-10, Volume: 5

    Topics: Animals; Antineoplastic Agents; Calcium; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Evoked Potentials; Fluorouracil; Ileum; Immunohistochemistry; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Ions; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Neoplasms; Oxytocin; Rats; Rats, Wistar; Receptors, Oxytocin; Wound Healing; Xanthones

2015
Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.
    Nature communications, 2016, Feb-23, Volume: 7

    Topics: Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Carrier Proteins; Celecoxib; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dinoprostone; In Vitro Techniques; Indoles; Indomethacin; Inflammasomes; Interleukin-1beta; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Macrophages, Peritoneal; Mice; Mice, Knockout; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphoproteins; Prostaglandin Antagonists; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction; Scorpion Stings; Scorpion Venoms; Scorpions; Xanthones

2016