Page last updated: 2024-09-03

ah 6809 and h 89

ah 6809 has been researched along with h 89 in 7 studies

Compound Research Comparison

Studies
(ah 6809)
Trials
(ah 6809)
Recent Studies (post-2010)
(ah 6809)
Studies
(h 89)
Trials
(h 89)
Recent Studies (post-2010) (h 89)
1631491,6190409

Protein Interaction Comparison

ProteinTaxonomyah 6809 (IC50)h 89 (IC50)
Rho-associated protein kinase 2Homo sapiens (human)1.9504
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)0.12
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.073
cAMP-dependent protein kinase catalytic subunit alpha Mus musculus (house mouse)0.381
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)0.6365
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)0.6365
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)0.6365
Ribosomal protein S6 kinase beta-1Homo sapiens (human)0.08
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)1.9886
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)0.5417
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)0.27
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)0.3207

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kinsella, BT; Walsh, MT1
Bonewald, LF; Cheng, B; Cherian, PP; Gu, S; Jiang, JX; Sprague, E1
Belvisi, MG; Catley, MC; Clarke, DL; Giembycz, MA; Newton, R; Yacoub, MH1
Abruzzese, JL; Cognetti, F; McConkey, DJ; Nawrocki, ST; Pino, MS; Xiong, HQ1
Cho, EA; Juhnn, YS; Kim, SH; Kim, WH; Oh, JM; Song, YS1
Liu, J; Qian, X; Zhang, J1
Lee, YS; Shehzad, A; Yeo, HS1

Other Studies

7 other study(ies) available for ah 6809 and h 89

ArticleYear
Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors.
    British journal of pharmacology, 2000, Volume: 131, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Biological Transport; Blood Platelets; Calcium; Cells, Cultured; Dinoprostone; Drug Interactions; Enzyme Inhibitors; Epoprostenol; Humans; Indoles; Isoquinolines; Maleimides; Prostaglandin Antagonists; Prostaglandins; Protein Isoforms; Receptors, Epoprostenol; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Thromboxane; Signal Transduction; Sulfonamides; Vasoconstrictor Agents; Xanthenes; Xanthones

2000
Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor.
    The Journal of biological chemistry, 2003, Oct-31, Volume: 278, Issue:44

    Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cell Line; Cells, Cultured; Connexin 43; Culture Media, Conditioned; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Gap Junctions; Isoenzymes; Isoquinolines; Models, Biological; Osteocytes; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stress, Mechanical; Sulfonamides; Time Factors; Xanthones

2003
Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.
    British journal of pharmacology, 2004, Volume: 141, Issue:7

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Adenoviridae; Adolescent; Adult; Aged; Alprostadil; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Female; Gene Expression; Genetic Vectors; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Interleukin-1; Isoquinolines; Male; Middle Aged; Misoprostol; Myocytes, Smooth Muscle; Prostaglandins E, Synthetic; Protein Isoforms; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Sulfonamides; Trachea; Xanthones

2004
Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells.
    Cancer biology & therapy, 2005, Volume: 4, Issue:11

    Topics: Cell Line, Tumor; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Models, Biological; Pancreatic Neoplasms; Phosphorylation; Prostaglandin Antagonists; Sulfonamides; Xanthones

2005
Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells.
    Carcinogenesis, 2010, Volume: 31, Issue:3

    Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Humans; Hydrogen Peroxide; Isoquinolines; Neoplasm Proteins; Oncogene Proteins, Viral; Proteasome Endopeptidase Complex; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Small Interfering; Sulfonamides; Ubiquitin; Uterine Cervical Neoplasms; Wortmannin; Xanthones

2010
Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway.
    The Journal of biological chemistry, 2011, Jan-21, Volume: 286, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Cell Line; Chemokine CCL5; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Interferon-gamma; Interleukin-2; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Nitrobenzenes; Prostaglandin Antagonists; Protein Kinase Inhibitors; Shock, Septic; Signal Transduction; Sulfonamides; Tumor Escape; Xanthones

2011
Prostaglandin E2 blocks menadione-induced apoptosis through the Ras/Raf/Erk signaling pathway in promonocytic leukemia cell lines.
    Molecules and cells, 2012, Volume: 33, Issue:4

    Topics: Apoptosis; Cell Survival; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Isoquinolines; Lamin Type B; Leukemia; Lipid Peroxidation; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Receptors, Prostaglandin E, EP2 Subtype; Sulfonamides; Vitamin K 3; Xanthones

2012