Page last updated: 2024-09-03

ah 6809 and alprostadil

ah 6809 has been researched along with alprostadil in 28 studies

Compound Research Comparison

Studies (ah 6809)	Trials (ah 6809)	Recent Studies (post-2010) (ah 6809)	Studies (alprostadil)	Trials (alprostadil)	Recent Studies (post-2010) (alprostadil)
163	1	49	7,136	864	761

Protein Interaction Comparison

Protein	Taxonomy	ah 6809 (IC50)	alprostadil (IC50)
Multidrug resistance-associated protein 4	Homo sapiens (human)		2.3
Solute carrier organic anion transporter family member 2B1	Rattus norvegicus (Norway rat)		0.0358

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.57)	18.7374
1990's	6 (21.43)	18.2507
2000's	13 (46.43)	29.6817
2010's	6 (21.43)	24.3611
2020's	2 (7.14)	2.80

Authors

Authors	Studies
Hirata, M; Kiriyama, M; Kobayashi, T; Narumiya, S; Sugimoto, Y; Ushikubi, F	1
Abramovitz, M; Boie, Y; Metters, KM; Neuschäfer-Rube, F; Püschel, GP; Sawyer, N; Slipetz, DM; Stocco, R; Ungrin, MD	1
Davis, TL; Sharif, NA	1
Malinowska, B; Molderings, G; Schlicker, E	1
Coleman, RA; Kennedy, I; Sheldrick, RL	1
Koda, H; Kumazawa, T; Mizumura, K	1
Fukusako, H; Koda, H; Kumazawa, T; Mizumura, K	1
Artibani, W; Corsi, M; Palea, S; Pietra, C; Romano, O; Toson, G; Trist, DG	1
Breuiller-Fouché, M; Cabrol, D; Dallot, E; Ferré, F; Leroy, MJ; Schmitz, T	1
Andelfinger, G; Bouayad, A; Chemtob, S; Clyman, RI; Fouron, JC; Gobeil, F; Kajino, H; Skoll, A; Varma, DR; Vazquez, A; Waleh, N	1
Abayasekara, DR; Bernal, AL; Harris, TE; Michael, AE; Squires, PE	1
Heinemann, A; Holzer, P; Peskar, BA; Shahbazian, A	1
Chakrabarti, S; Chakraborty, C; Lala, PK; Timoshenko, AV; Xu, G	1
Belvisi, MG; Catley, MC; Clarke, DL; Giembycz, MA; Newton, R; Yacoub, MH	1
Akaike, A; Banno, Y; Fushimi, K; Nakashima, S; Shimizu, K; Takigawa, M	1
Berliner, JA; Cruz, D; Dun, M; Gharavi, N; Koroniak, L; Li, R; Montoya, D; Mouillesseaux, KP	1
Matlhagela, K; Taub, M	1
Abayasekara, DR; Bernal, AL; Chandras, C; Harris, TE; Michael, AE	1
Bradding, P; Brightling, CE; Cockerill, SL; Cruse, G; Duffy, SM	1
Juvet, SC; Lee, BP; Zhang, L	1
Baun, M; Gupta, S; Jansen-Olesen, I; Myren, M; Olesen, J; Ploug, KB	1
Belvisi, MG; Birrell, MA; Buckley, J; Clarke, DL; Maher, SA; Nials, AT	1
Brant, KA; Fabisiak, JP	1
Chae, IG; Chun, KS; Kwon, TK; Min, KJ; Woo, SM	1
Chadee, K; Lejeune, M; Moreau, F	1
Cao, J; Deng, Y; Fu, C; Gao, L; Gao, R; Liu, B; Mao, W; Shen, Y; Wu, J; Wu, X; Zhang, N; Zhang, S; Zhang, Y	1
Qu, J; Reinach, PS; Srinivasalu, N; Su, Y; Xu, R; Zhang, S; Zhou, X; Zhu, Y	1
Cao, J; Feng, S; Fu, C; Li, Q; Liu, B; Mao, W; Zhang, S; Zhao, J	1

Other Studies

28 other study(ies) available for ah 6809 and alprostadil

Article	Year
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British journal of pharmacology, 1997, Volume: 122, Issue:2 Topics: Animals; CHO Cells; Cricetinae; Ligands; Mice; Prostaglandins; Receptors, Prostaglandin; Transfection	1997
Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. European journal of pharmacology, 1997, Dec-11, Volume: 340, Issue:2-3 Topics: Aequorin; Amino Acid Sequence; Animals; Blotting, Northern; Cell Line; Cell Membrane; Cloning, Molecular; Dinoprostone; Humans; Kidney; Ligands; Liver; Luminescent Measurements; Male; Mice; Molecular Sequence Data; Radioligand Assay; Rats; Receptors, Prostaglandin E; Spleen	1997
Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:4 Topics: Algorithms; Alprostadil; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; Dinoprost; Dinoprostone; DNA, Recombinant; Dose-Response Relationship, Drug; Epoprostenol; Humans; Ligands; Prostaglandin D2; Prostaglandins E; Radioligand Assay; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Tritium	2002
Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype. British journal of pharmacology, 1992, Volume: 107, Issue:2 Topics: Alprostadil; Animals; Dinoprost; Dinoprostone; Electric Stimulation; Indomethacin; Misoprostol; Norepinephrine; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandins; Rats; Receptors, Prostaglandin; Receptors, Prostaglandin E; Vena Cava, Inferior; Xanthenes; Xanthones; Yohimbine	1992
New evidence with selective agonists and antagonists for the subclassification of PGE2-sensitive (EP) receptors. Advances in prostaglandin, thromboxane, and leukotriene research, 1987, Volume: 17A Topics: Alprostadil; Animals; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; In Vitro Techniques; Muscle Contraction; Prostaglandins E; Prostaglandins E, Synthetic; Receptors, Prostaglandin; Receptors, Prostaglandin E; Xanthenes; Xanthones	1987
Involvement of EP3 subtype of prostaglandin E receptors in PGE2-induced enhancement of the bradykinin response of nociceptors. Brain research, 1993, Dec-31, Volume: 632, Issue:1-2 Topics: Alprostadil; Animals; Bradykinin; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Epididymis; Hot Temperature; In Vitro Techniques; Male; Nociceptors; Physical Stimulation; Prostaglandin Antagonists; Receptors, Prostaglandin E; Testis; Xanthenes; Xanthones	1993
EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in response to bradykinin and heat. Journal of neurophysiology, 1996, Volume: 75, Issue:6 Topics: Alprostadil; Animals; Bradykinin; Cyclic AMP; Dinoprostone; Dogs; Hot Temperature; Nociceptors; Prostaglandin Antagonists; Prostaglandins E, Synthetic; Receptors, Prostaglandin E; Xanthenes; Xanthones	1996
Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder. British journal of pharmacology, 1998, Volume: 124, Issue:5 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Biphenyl Compounds; Dinoprost; Dinoprostone; Electric Stimulation; Heptanoic Acids; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Prostaglandin Antagonists; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Thromboxane; Thromboxane A2; Urinary Bladder; Xanthenes; Xanthones	1998
EP(4) receptors mediate prostaglandin E(2)-stimulated glycosaminoglycan synthesis in human cervical fibroblasts in culture. Molecular human reproduction, 2001, Volume: 7, Issue:4 Topics: Alprostadil; Biphenyl Compounds; Cells, Cultured; Cervix Uteri; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Female; Fibroblasts; Glycosaminoglycans; Humans; Prostaglandin Antagonists; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Xanthenes; Xanthones	2001
Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:5 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Alprostadil; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Anti-Ulcer Agents; Binding, Competitive; Biphenyl Compounds; Colforsin; Dinoprost; Ductus Arteriosus; Female; Fetus; Polymerase Chain Reaction; Potassium Channels; Pregnancy; Prostaglandin Antagonists; Prostaglandins E, Synthetic; Radioligand Assay; Receptors, Prostaglandin E; Sheep; Tritium; Vasoconstriction; Xanthenes; Xanthones	2001
Human granulosa-lutein cells express functional EP1 and EP2 prostaglandin receptors. Biochemical and biophysical research communications, 2001, Aug-03, Volume: 285, Issue:5 Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Calcium; Cells, Cultured; Cyclic AMP; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Dose-Response Relationship, Drug; Female; Granulosa Cells; Humans; Intracellular Fluid; Lutein; Progesterone; Prostaglandin Antagonists; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; RNA, Messenger; Xanthenes; Xanthones	2001
Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. British journal of pharmacology, 2002, Volume: 137, Issue:7 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Guinea Pigs; Hydantoins; Hydrazines; Iloprost; In Vitro Techniques; Intestine, Small; Leukotriene Antagonists; Leukotriene D4; Male; Oxazepines; Peristalsis; Prostaglandin D2; Prostaglandins A; Receptors, Leukotriene; Receptors, Prostaglandin; Xanthenes; Xanthones; Yohimbine	2002
Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells. Experimental cell research, 2003, Oct-01, Volume: 289, Issue:2 Topics: Alprostadil; Animals; Breast Neoplasms; Carcinoma; Cell Movement; Colforsin; Cyclic AMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Indoles; Isoenzymes; Mammary Neoplasms, Experimental; Membrane Proteins; Mice; Neoplasm Invasiveness; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Tumor Cells, Cultured; Up-Regulation; Xanthenes; Xanthones	2003
Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF. British journal of pharmacology, 2004, Volume: 141, Issue:7 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Adenoviridae; Adolescent; Adult; Aged; Alprostadil; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Female; Gene Expression; Genetic Vectors; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Interleukin-1; Isoquinolines; Male; Middle Aged; Misoprostol; Myocytes, Smooth Muscle; Prostaglandins E, Synthetic; Protein Isoforms; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Sulfonamides; Trachea; Xanthones	2004
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. Osteoarthritis and cartilage, 2004, Volume: 12, Issue:11 Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Calpain; Cell Line, Tumor; Chondrocytes; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Diclofenac; Dinoprostone; Humans; Nitrobenzenes; Phenylpropionates; Prostaglandin Antagonists; Sulfonamides; Tumor Necrosis Factor-alpha; Up-Regulation; Xanthones	2004
Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC. Circulation research, 2006, Mar-17, Volume: 98, Issue:5 Topics: Alprostadil; Atherosclerosis; Cells, Cultured; Dinoprostone; Foam Cells; Humans; Interleukin-10; Isoprostanes; Macrophages; Monocytes; Oxidation-Reduction; Phosphatidylcholines; Phospholipid Ethers; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; RNA, Messenger; Tumor Necrosis Factor-alpha; Xanthones	2006
Involvement of EP1 and EP2 receptors in the regulation of the Na,K-ATPase by prostaglandins in MDCK cells. Prostaglandins & other lipid mediators, 2006, Volume: 79, Issue:1-2 Topics: Alprostadil; Animals; Cell Line; Dinoprostone; Dogs; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hydrazines; Ion Transport; Kidney Tubules, Distal; Oxazepines; Prostaglandin Antagonists; Protein Kinase C; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Sodium-Potassium-Exchanging ATPase; Xanthones	2006
PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells. The Journal of endocrinology, 2007, Volume: 194, Issue:3 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Alprostadil; Cells, Cultured; Cortisone; Cyclic AMP; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Hydrocortisone; Luteal Cells; Progesterone; Prostaglandin Antagonists; Prostaglandins E, Synthetic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Xanthones	2007
Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration. European journal of immunology, 2008, Volume: 38, Issue:9 Topics: Alprostadil; Benzimidazoles; Calcium Channel Agonists; Cell Movement; Chemotaxis; Dinoprostone; Histamine Release; Humans; Mast Cells; Potassium Channels; Prostaglandin Antagonists; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Xanthones	2008
Prostaglandin E2 signaling through E prostanoid receptor 2 impairs proliferative response of double negative regulatory T cells. International immunopharmacology, 2009, Volume: 9, Issue:5 Topics: Alprostadil; Animals; CD4 Antigens; CD8 Antigens; Cell Proliferation; Clone Cells; Cytotoxicity, Immunologic; Dinoprostone; Immunomagnetic Separation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prostaglandin Antagonists; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; T-Lymphocytes, Regulatory; Xanthones	2009
Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine. Cephalalgia : an international journal of headache, 2010, Volume: 30, Issue:9 Topics: Adenine; Alprostadil; Animals; Cerebral Arteries; Dinoprostone; Enzyme Inhibitors; Male; Meningeal Arteries; Migraine Disorders; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Trigeminal Nerve; Vasodilation; Xanthones	2010
EP4 receptor as a new target for bronchodilator therapy. Thorax, 2011, Volume: 66, Issue:12 Topics: Alprostadil; Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Bronchodilator Agents; Dinoprostone; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; Macaca fascicularis; Methyl Ethers; Mice; Mice, Inbred C57BL; Naphthalenes; Phenylbutyrates; Prostanoic Acids; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Regression Analysis; Species Specificity; Trachea; Xanthones	2011
Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts. American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:1 Topics: Alprostadil; Biomimetics; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dinoprostone; Drug Synergism; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-8; Lung; Nickel; p38 Mitogen-Activated Protein Kinases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Xanthones	2013
Silymarin suppresses the PGE2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways. Molecular carcinogenesis, 2015, Volume: 54, Issue:3 Topics: Alprostadil; Antioxidants; Benzodioxoles; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; HCT116 Cells; HT29 Cells; Humans; Integrases; Kidney Neoplasms; Phosphorylation; Prostaglandin Antagonists; Quinazolines; Receptors, Prostaglandin E, EP2 Subtype; RNA Interference; RNA, Small Interfering; Signal Transduction; Silymarin; src-Family Kinases; STAT3 Transcription Factor; Wound Healing; Xanthones	2015
Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4. PloS one, 2014, Volume: 9, Issue:11 Topics: Alprostadil; Caco-2 Cells; Cell Membrane Permeability; Claudin-4; Cytokines; Down-Regulation; Humans; Interferon-gamma; Receptors, Prostaglandin E, EP2 Subtype; RNA Interference; RNA, Messenger; RNA, Small Interfering; Tight Junctions; Xanthones	2014
PTGER2 activation induces PTGS-2 and growth factor gene expression in endometrial epithelial cells of cattle. Animal reproduction science, 2017, Volume: 187 Topics: Alprostadil; Animals; Cattle; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Endometrium; Epithelial Cells; Female; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Interleukin-8; MAP Kinase Signaling System; Prostaglandin Antagonists; Receptors, Prostaglandin E, EP2 Subtype; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Xanthones	2017
Crosstalk between EP2 and PPARα Modulates Hypoxic Signaling and Myopia Development in Guinea Pigs. Investigative ophthalmology & visual science, 2020, 07-01, Volume: 61, Issue:8 Topics: Alprostadil; Animals; Cyclic AMP; Extracellular Matrix; Guinea Pigs; Hypoxia-Inducible Factor 1, alpha Subunit; Myopia, Degenerative; PPAR alpha; Prostaglandin Antagonists; Prostaglandins E, Synthetic; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Xanthones	2020
Proliferation of bovine endometrial epithelial cells is promoted by prostaglandin E Prostaglandins, leukotrienes, and essential fatty acids, 2021, Volume: 174 Topics: Alprostadil; Aminopyridines; Animals; Cattle; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endometrium; Epithelial Cells; Female; Proliferating Cell Nuclear Antigen; Purines; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Up-Regulation; Xanthones	2021