agmatine and morphine
agmatine has been researched along with morphine in 43 studies
Research
Studies (43)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (16.28) | 18.2507 |
| 2000's | 25 (58.14) | 29.6817 |
| 2010's | 11 (25.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Jain, S; Kolesnikov, Y; Pasternak, GW | 1 |
| Fairbanks, CA; Wilcox, GL | 1 |
| Benedek, G; Dobos, I; Horváth, G; Kékesi, G; Klimscha, W; Szikszay, M | 1 |
| Li, J; Li, X; Pei, G; Qin, BY | 4 |
| Uzbay, IT; Yeşilyurt, O | 1 |
| Li, J; Li, X; Qin, BY; Su, RB | 1 |
| Aricioglu-Kartal, F; Regunathan, S | 1 |
| Li, J; Qin, BY; Su, RB | 1 |
| Li, J; Lu, G; Qin, BY; Su, RB | 1 |
| Aricioglu, F; Paul, IA; Regunathan, S | 1 |
| Roerig, SC | 1 |
| Llorente, J; Pineda, J; Ruiz-Durantez, E; Ugedo, L; Ulibarri, I | 1 |
| Aricioglu, F; Dulger, G; Ercil, E | 1 |
| Bakalkin, G; Marinova, Z; Nakagawasai, O; Niijima, F; Sakurada, S; Sato, T; Satoh, S; Tadano, T; Takahashi, H; Tan-No, K; Terenius, L; Yakovleva, T | 1 |
| Li, J; Liu, Y; Lu, XQ; Su, RB; Wei, XL; Yu, SZ; Yuan, BL | 1 |
| Dehpour, AR; Ebrahimkhani, MR; Ghaffari, K; Homayoun, H; Honar, H; Jannati, A; Kiani, S; Noorian, AR; Rashidi, N; Riazi, K | 1 |
| Li, J; Liu, Y; Lu, XQ; Piletz, JE; Qin, BY; Su, RB; Wu, N; Xu, B; Zheng, JQ | 1 |
| Dehpour, AR; Ghahremani, MH; Khoshnoodi, MA; Motiei-Langroudi, R; Tahaei, SA; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N | 1 |
| Dehpour, AR; Ghahremani, MH; Khoshnoodi, MA; Motiei-Langroudi, R; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N | 1 |
| Fairbanks, CA; Kitto, KF | 1 |
| Cong, B; Li, J; Liu, Y; Lu, XQ; Su, RB; Wu, N; Zheng, JQ | 1 |
| Regunathan, S | 1 |
| Amin, M; Rawls, SM; Zisk, J | 1 |
| Esashi, A; Furuta, S; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Tadano, T; Tan-No, K; Yasuhara, H | 1 |
| Li, J; Lu, XQ; Su, RB; Wei, XL; Wu, N; Zheng, JQ | 1 |
| Gong, ZH; Huang, Y; Li, J; Liu, Y; Lu, XQ; Su, RB; Wei, XL; Wu, N | 1 |
| Ding, T; Li, J; Liu, Y; Liu, ZM; Lu, XQ; Ren, YH; Su, RB; Wu, N | 1 |
| Li, J; Liu, ZM; Lu, XQ; Su, RB; Wang, WP; Wu, N | 1 |
| Bi, GH; Dong, HJ; Li, J; Lu, W; Su, RB; Yang, Z; Zhao, YQ | 1 |
| Dong, HJ; Gong, ZH; Li, J; Lu, W; Su, RB | 1 |
| Li, J; Liu, Y; Lu, XQ; Su, RB; Wang, XF; Wu, N | 1 |
| Bhalla, S; Gulati, A; Rapolaviciute, V | 1 |
| Li, JX; Winter, JC; Zhang, Y | 1 |
| Li, JX; Peng, BW; Thorn, DA; Winter, JC; Zhang, Y | 1 |
| Andurkar, SV; Bhalla, S; Gulati, A | 1 |
| Bahremand, A; Dehpour, AR; Derakhshanian, H; Ebrahimi, A; Fadakar, K; Moghaddas, P; Payandemehr, B; Rahimian, R; Saadat, S | 1 |
| Chen, YH; Gu, N; Lan, ZP; Sun, YY; Xiong, LZ | 1 |
| Li, J; Su, RB; Wang, XF; Wu, N; Zhao, TY | 1 |
| Chen, WQ; Li, J; Li, YF; Liu, Y; Lu, GY; Wu, N | 1 |
Reviews
2 review(s) available for agmatine and morphine
| Article | Year |
|---|---|
A biphasic opioid function modulator: agmatine.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Morphine; Morphine Dependence; Neurotransmitter Agents; Receptors, Opioid; Signal Transduction | 2003 |
Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Morphine; Morphine Dependence; Pain | 2006 |
Other Studies
41 other study(ies) available for agmatine and morphine
| Article | Year |
|---|---|
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Modulation of opioid analgesia by agmatine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Agmatine; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Gastrointestinal Transit; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pyrrolidines; Receptors, Opioid, kappa | 1996 |
Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance.
Topics: Agmatine; Analgesics, Opioid; Animals; Drug Tolerance; Indazoles; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1997 |
Effect of intrathecal agmatine on inflammation-induced thermal hyperalgesia in rats.
Topics: Agmatine; Analgesics, Opioid; Animals; Carrageenan; Dose-Response Relationship, Drug; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Male; Morphine; Pain Threshold; Rats; Rats, Wistar; Time Factors | 1999 |
Analgesic effect of agmatine and its enhancement on morphine analgesia in mice and rats.
Topics: Agmatine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Clonidine; Drug Synergism; Female; Imidazoles; Imidazoline Receptors; Male; Mice; Morphine; Rats; Rats, Wistar; Receptors, Drug | 1999 |
Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro.
Topics: Agmatine; Analgesics, Opioid; Animals; Drug Tolerance; Guinea Pigs; Ileum; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Receptors, Drug | 1998 |
Effects of agmatine on tolerance to and substance dependence on morphine in mice.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Drug Tolerance; Female; Idazoxan; Male; Mice; Morphine; Morphine Dependence; Substance Withdrawal Syndrome | 1999 |
Influence of agmatine in adaptation of cAMP signal transduction system of opiate receptors.
Topics: Adaptation, Physiological; Adrenergic alpha-Antagonists; Agmatine; Analgesics; Animals; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Idazoxan; Imidazoline Receptors; Mice; Morphine; Neuroblastoma; Rats; Receptors, Drug; Signal Transduction; Tumor Cells, Cultured | 1999 |
Agmatine potentiates the analgesic effect of morphine by an alpha(2)-adrenoceptor-mediated mechanism in mice.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Male; Mice; Morphine; Nociceptors; Pain; Pain Measurement; Rats; Receptors, Adrenergic, alpha-2; Yohimbine | 2001 |
Down-regulation of MAO-B activity and imidazoline receptors in rat brain following chronic treatment of morphine.
Topics: Agmatine; Animals; Brain; Chromatography, High Pressure Liquid; Down-Regulation; Idazoxan; Imidazoline Receptors; Male; Monoamine Oxidase; Morphine; Morphine Dependence; Rats; Rats, Wistar; Receptors, Drug | 2001 |
Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues.
Topics: Agmatine; Analgesics, Opioid; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley | 2002 |
Modulation by alpha-difluoromethyl-ornithine and aminoguanidine of pain threshold, morphine analgesia and tolerance.
Topics: Acetic Acid; Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Behavior, Animal; Drug Tolerance; Eflornithine; Female; Guanidines; Hot Temperature; Idazoxan; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain Measurement; Pain Threshold | 2003 |
Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice.
Topics: Agmatine; Animals; Behavior, Animal; Central Nervous System; Drug Interactions; Female; Male; Mice; Mice, Knockout; Morphine; Morphine Dependence; Naloxone; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Substance Withdrawal Syndrome | 2004 |
Spinal and supraspinal agmatine activate different receptors to enhance spinal morphine antinociception.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Norepinephrine; Pain Measurement; Receptors, Adrenergic, alpha-2; Spinal Cord | 2003 |
Agmatine-morphine interaction on nociception in mice.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Interactions; Enzyme Inhibitors; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement | 2003 |
Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Idazoxan; Ileum; Male; Morphine; Morphine Dependence; Muscle Contraction; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome; Yohimbine | 2003 |
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation.
Topics: Agmatine; Analysis of Variance; Animals; Behavior, Animal; Biguanides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Antagonists; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Nociceptin Receptor; Piperidines; Protein Precursors; Receptors, Opioid; Spinal Cord; Time Factors | 2005 |
Inhibition by agmatine on morphine-induced conditioned place preference in rats.
Topics: Agmatine; Animals; Choice Behavior; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; Male; Morphine; Narcotics; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Transcription Factors | 2005 |
The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analysis of Variance; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Morphine; Pentylenetetrazole; Receptors, Adrenergic, alpha-2; Seizures; Yohimbine | 2005 |
IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence.
Topics: Agmatine; Animals; CHO Cells; Cricetinae; Cyclic AMP; Dizocilpine Maleate; Imidazoles; Imidazoline Receptors; Intracellular Signaling Peptides and Proteins; Morphine; Naloxone; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase | 2005 |
Agmatine potentiates morphine-induced conditioned place preference in mice: modulation by alpha2-adrenoceptors.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Morphine; Receptors, Adrenergic, alpha-2 | 2006 |
Involvement of nitric oxide system in enhancement of morphine-induced conditioned place preference by agmatine in male mice.
Topics: Agmatine; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Male; Mice; Morphine; Narcotics; Nitric Oxide | 2006 |
Supraspinally administered agmatine prevents the development of supraspinal morphine analgesic tolerance.
Topics: Agmatine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Male; Mice; Morphine; Pain Measurement | 2006 |
Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor.
Topics: Agmatine; Animals; Calcium; Calcium Signaling; CHO Cells; CREB-Binding Protein; Cricetinae; Cricetulus; Extracellular Signal-Regulated MAP Kinases; Imidazoline Receptors; Intracellular Signaling Peptides and Proteins; Morphine; Naloxone; Opioid-Related Disorders; Proto-Oncogene Proteins c-fos; Receptors, Drug | 2006 |
Agmatine blocks morphine-evoked hyperthermia in rats.
Topics: Agmatine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Biogenic Amines; Body Temperature Regulation; Dose-Response Relationship, Drug; Drug Interactions; Fever; Idazoxan; Imidazoline Receptors; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Opioid, mu; Yohimbine | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Agmatine inhibits morphine-induced locomotion sensitization and morphine-induced changes in striatal dopamine and metabolites in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Agmatine; Analysis of Variance; Animals; Behavior, Animal; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Dynorphins; Gene Expression Regulation; Homovanillic Acid; Idazoxan; Locomotion; Male; Morphine; Narcotics; Rats; Rats, Wistar; Time Factors | 2007 |
Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys.
Topics: Agmatine; Analgesics, Opioid; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Intubation, Gastrointestinal; Macaca mulatta; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2008 |
Agmatine inhibits morphine-induced drug discrimination in rats.
Topics: Agmatine; Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Extinction, Psychological; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Substance-Related Disorders | 2008 |
Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats.
Topics: Agmatine; Animals; Disease Models, Animal; Extinction, Psychological; Infusions, Intravenous; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Substance-Related Disorders | 2009 |
Effect of agmatine on long-term potentiation in morphine-treated rats.
Topics: Agmatine; Animals; Dentate Gyrus; Drug Interactions; Hippocampus; Idazoxan; Imidazoline Receptors; Long-Term Potentiation; Male; Morphine; Rats; Rats, Wistar | 2010 |
Agmatine inhibits morphine-induced memory impairment in the mouse step-down inhibitory avoidance task.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Idazoxan; Imidazoline Receptors; Male; Memory Disorders; Mental Recall; Mice; Morphine | 2010 |
Agmatine modulates neuroadaptations of glutamate transmission in the nucleus accumbens of repeated morphine-treated rats.
Topics: Adaptation, Physiological; Agmatine; Animals; Biological Transport; Extracellular Space; Gene Expression Regulation; Glutamic Acid; Male; Microdialysis; Morphine; Morphine Dependence; Neurons; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes | 2011 |
Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.
Topics: Agmatine; Analgesics; Animals; Dansyl Compounds; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Oxycodone; Receptors, Adrenergic, alpha-2; Receptors, Endothelin; Yohimbine | 2011 |
Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Yohimbine | 2011 |
Effects of imidazoline I₂ receptor ligands on morphine- and tramadol-induced antinociception in rats.
Topics: Agmatine; Analgesics; Animals; Behavior, Animal; Benzofurans; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Imidazoline Receptors; Ligands; Morphine; Rats; Rats, Sprague-Dawley; Tramadol | 2011 |
Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Agmatine; Animals; Body Temperature Regulation; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Hypothermia; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Oxycodone; Receptor, Endothelin A; Receptors, Adrenergic, alpha-2; Yohimbine | 2013 |
Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine.
Topics: Agmatine; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epilepsy, Tonic-Clonic; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pentylenetetrazole; Seizures | 2013 |
[Effects of the spinal cord intrathecal injected to agmatine on intrathecal morphine analgesia].
Topics: Agmatine; Analgesia; Animals; Injections, Spinal; Male; Morphine; Rats; Rats, Sprague-Dawley; Spinal Cord | 2014 |
Agmatine Prevents Adaptation of the Hippocampal Glutamate System in Chronic Morphine-Treated Rats.
Topics: Adaptation, Physiological; Agmatine; Analysis of Variance; Animals; Down-Regulation; Drug Interactions; Electrochemical Techniques; Extracellular Fluid; Glutamic Acid; Hippocampus; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2016 |
Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats.
Topics: Agmatine; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Hippocampus; Male; Morphine; Morphine Dependence; Neural Stem Cells; Rats; Rats, Wistar; Signal Transduction; Time Factors | 2018 |