aglafoline and rocaglamide

aglafoline has been researched along with rocaglamide* in 2 studies

Other Studies

2 other study(ies) available for aglafoline and rocaglamide

Article	Year
Ponapensin, a cyclopenta[bc]benzopyran with potent NF-kappaB inhibitory activity from Aglaia ponapensis. Bioorganic & medicinal chemistry letters, 2007, Jan-01, Volume: 17, Issue:1 Two new compounds, a cyclopenta[bc]benzopyran, ponapensin (1), and an aglaialactone, 5,6-desmethylenedioxy-5-methoxy-aglalactone (2), together with nine known compounds were isolated from the CHCl(3) soluble extract of the leaves and twigs of Aglaia ponapensis. Their structures were established by spectroscopic data interpretation. Ponapensin (1) exhibited significant NF-kappaB inhibitory activity in an Elisa assay, and was found to be more potent than the positive control rocaglamide. All of the compounds isolated were also tested in a panel of human cancer cell lines, with the known sterol E-volkendousin (3) and methyl rocaglate (aglafoline) found to be the only active substances. Topics: Aglaia; Benzofurans; Benzopyrans; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Heterocyclic Compounds, 3-Ring; Humans; Molecular Structure; NF-kappa B; Plant Leaves	2007
Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia. Journal of natural products, 1997, Volume: 60, Issue:6 Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively. Topics: Animals; Antineoplastic Agents, Phytogenic; Benzofurans; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured	1997

Article

Year

Ponapensin, a cyclopenta[bc]benzopyran with potent NF-kappaB inhibitory activity from Aglaia ponapensis.

Bioorganic & medicinal chemistry letters, 2007, Jan-01, Volume: 17, Issue:1

Two new compounds, a cyclopenta[bc]benzopyran, ponapensin (1), and an aglaialactone, 5,6-desmethylenedioxy-5-methoxy-aglalactone (2), together with nine known compounds were isolated from the CHCl(3) soluble extract of the leaves and twigs of Aglaia ponapensis. Their structures were established by spectroscopic data interpretation. Ponapensin (1) exhibited significant NF-kappaB inhibitory activity in an Elisa assay, and was found to be more potent than the positive control rocaglamide. All of the compounds isolated were also tested in a panel of human cancer cell lines, with the known sterol E-volkendousin (3) and methyl rocaglate (aglafoline) found to be the only active substances.

Topics: Aglaia; Benzofurans; Benzopyrans; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Heterocyclic Compounds, 3-Ring; Humans; Molecular Structure; NF-kappa B; Plant Leaves

2007

Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.

Journal of natural products, 1997, Volume: 60, Issue:6

Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.

Topics: Animals; Antineoplastic Agents, Phytogenic; Benzofurans; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured

1997