agelasine-d and manool

An improved synthesis of (+)-agelasine D (10) from (+)-manool is reported together with cytotoxic and antibacterial data for agelasine D and structurally close synthetic analogues. These compounds display a broad spectrum of antibacterial activities including effects on M. tuberculosis and Gram-positive and Gram-negative bacteria (both aerobes and anaerobes). They exhibit profound cytotoxic activity against several cancer cells, including a multidrug-resistant cell line. (+)-Agelasine D (10) has been isolated earlier from a marine sponge (Agelas sp.).

Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Diterpenes; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Mice; Microbial Sensitivity Tests; Molecular Structure; Porifera; Purines; Stereoisomerism; Tumor Cells, Cultured