agar and enzastaurin

agar has been researched along with enzastaurin* in 1 studies

Other Studies

1 other study(ies) available for agar and enzastaurin

ArticleYear
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments.
    Investigational new drugs, 2007, Volume: 25, Issue:3

    Enzastaurin (LY317615.HCl) is an antiproliferative agent targeted specifically against PKC-beta. We have investigated the antitumoral effects of Enzastaurin against human cancer cell lines and freshly explanted human tumor tissue. Ten human cancer cell lines (NSCLC, colon, and thyroid) and human tumor specimens from 72 patients were used for in vitro studies in a cloning assay (HTCA). Cell lines and primary tumor cells were exposed to Enzastaurin for either 1 h or 7 days, or for 1 h or 21 days. At clinically achievable concentrations of Enzastaurin, inhibition of cell growth was observed for lung, colorectal, and thyroid cancer cell lines in a concentration dependent manner. Patient specimens exposed 1 h or 21 days to 1,400 nM Enzastaurin demonstrated inhibition rates of 24 and 32%, respectively. Marked inhibitory effects were observed in breast, thyroid, head/neck, non-small cell lung cancer, pancreatic cancer, and melanoma. In addition to its established antiangiogenic effects, Enzastaurin has direct antitumor activity against established human cancer cell lines and primary tumor specimens. This warrants further clinical development in tumors which have been identified to be potentially sensitive to Enzastaurin.

    Topics: Agar; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Culture Media; Dose-Response Relationship, Drug; Humans; Indoles; Neoplasms; Neoplastic Stem Cells; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Time Factors; Tumor Cells, Cultured; Tumor Stem Cell Assay

2007