ag 1879 and genistein

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

Topics: Adaptor Proteins, Signal Transducing; Animals; Aorta; Benzoquinones; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Genistein; GRB2 Adaptor Protein; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Pyrimidines; Quinazolines; Quinones; Rifabutin; Swine; Transcriptional Activation; Tyrphostins

Topics: Animals; Cinnamates; Enzyme Inhibitors; Genistein; Heart Ventricles; Membrane Potentials; Myocytes, Cardiac; Protein-Tyrosine Kinases; Pyrimidines; Rabbits; Sodium; Sodium Channels; Sulfides; Tyrphostins

Topics: Adrenergic beta-Agonists; Animals; Calcimycin; Cell Degranulation; Eosinophil Peroxidase; Eosinophils; Fenoterol; Genistein; Guinea Pigs; In Vitro Techniques; Ionophores; Male; Peroxidases; Phosphodiesterase Inhibitors; Pyrimidines; Receptors, Adrenergic, beta-2; src-Family Kinases; Time Factors

Topics: Binding Sites; CD18 Antigens; Cell Adhesion; Cytochalasin D; Cytokines; Cytoskeleton; Genistein; Humans; Imidazoles; Indoles; Integrin beta Chains; Magnesium; Maleimides; Microspheres; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nocodazole; Particle Size; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrimidines; Serum Albumin; src-Family Kinases; Superoxides; Technology, Pharmaceutical; Tissue Adhesions; Tumor Necrosis Factor-alpha

Topics: Calcium; Cysteine; Egtazic Acid; Enzyme Activation; Estrenes; Genistein; GTP-Binding Proteins; Humans; Inflammation Mediators; Leukotriene D4; Leukotrienes; Membrane Proteins; Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyrimidines; Pyrrolidinones; ras Proteins; Receptors, Leukotriene; Signal Transduction; U937 Cells

Topics: Apoptosis; Carcinoma, Medullary; Cell Division; Cell Line, Tumor; CSK Tyrosine-Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; src-Family Kinases; Thyroid Neoplasms

Topics: Animals; Cadmium; Chloride Channels; Enzyme Inhibitors; ErbB Receptors; Genistein; Heart Ventricles; Membrane Potentials; Pyrimidines; Quinazolines; Rabbits; src-Family Kinases; Tamoxifen; Ventricular Function

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction

Topics: Animals; Benzoquinones; Biological Transport; Chalcone; Chalcones; Deoxyglucose; Electric Stimulation; Focal Adhesion Kinase 2; Genistein; Glucose; Glucose Transporter Type 4; Hypoxia; In Vitro Techniques; Insulin; Lactams, Macrocyclic; Male; Muscle Contraction; Muscle, Skeletal; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Quinones; Rats; Rats, Wistar; Rifabutin; src-Family Kinases

Topics: Benzoquinones; Cell Differentiation; Cells, Cultured; Chorionic Gonadotropin, beta Subunit, Human; Female; Gene Expression Regulation; Genistein; Humans; Lactams, Macrocyclic; Placenta; Placental Lactogen; Pregnancy; Protein Kinase Inhibitors; Pyrimidines; Quinones; Rifabutin; RNA, Messenger; src-Family Kinases; Time Factors; Trophoblasts

Topics: Absorption; Animals; Bicarbonates; Carbon Dioxide; Dimethyl Sulfoxide; Enzyme Inhibitors; Female; Genistein; Imidazoles; Kidney Tubules, Proximal; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction

Topics: Amino Acid Motifs; Amino Acid Sequence; Anaplasma phagocytophilum; Animals; Bacterial Proteins; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Genistein; HL-60 Cells; Humans; Immunoblotting; Immunoprecipitation; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyrimidines; Time Factors; Tyrosine

Topics: Apoptosis; Calcium Signaling; Cell Survival; Genistein; Humans; Hydrogen Peroxide; Immunoprecipitation; Necrosis; Oxidative Stress; Phosphorylation; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Pyrimidines; RNA Interference; RNA, Small Interfering; Time Factors; Transfection; TRPM Cation Channels; Tumor Necrosis Factor-alpha; Tyrosine; U937 Cells

Topics: Acute-Phase Proteins; Animals; Bile Ducts; Carrier Proteins; Cholangitis, Sclerosing; Epithelium; Genistein; Lipopolysaccharides; Membrane Glycoproteins; Membrane Proteins; Myosin-Light-Chain Kinase; Occludin; Permeability; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Rats; RNA, Small Interfering; Tight Junctions; Toll-Like Receptor 4; Zonula Occludens-1 Protein

Topics: Animals; Benzoflavones; Cell Differentiation; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Genistein; Hazardous Substances; Humans; Macrophages; MAP Kinase Signaling System; Mice; Phosphorylation; Polychlorinated Dibenzodioxins; Pyrimidines; Quinazolines; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha

Topics: Action Potentials; Animals; Cell Size; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; ErbB Receptors; Genistein; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Myocytes, Cardiac; Osmotic Pressure; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Signal Transduction; src-Family Kinases; Tyrphostins; Vanadates

Topics: Androgens; Anilides; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Docetaxel; Drug Synergism; Genistein; Humans; Male; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Pyrimidines; src-Family Kinases; Taxoids; Tosyl Compounds

Topics: Cell Line; ErbB Receptors; Ether-A-Go-Go Potassium Channels; Genistein; Humans; Ion Channel Gating; Phosphotyrosine; Point Mutation; Pyrimidines; src-Family Kinases; Tyrphostins; Vanadates

Topics: Animals; Benzoquinones; Breast Neoplasms; Chlorocebus aethiops; COS Cells; DNA Damage; Estrogens, Catechol; Genistein; Glucuronosyltransferase; Humans; Lactams, Macrocyclic; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidines; Receptors, Estrogen; Rifabutin; src-Family Kinases; Transfection

Topics: Acetophenones; Benzopyrans; Butadienes; Chromones; Gene Expression Regulation, Enzymologic; Genistein; Hexosaminidases; Humans; Imidazoles; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Messenger; Tyrphostins

Topics: Apoptosis; Cells, Cultured; Entamoeba histolytica; Genistein; GPI-Linked Proteins; Humans; Neutrophils; Protein Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species; Receptors, IgG; src-Family Kinases

Topics: Blotting, Western; Dose-Response Relationship, Drug; ErbB Receptors; Genistein; HEK293 Cells; Humans; Immunoprecipitation; Membrane Potentials; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pyrimidines; src-Family Kinases; Time Factors; Transfection; Tyrphostins; Vanadates

Topics: Androstadienes; Animals; Calcium; CSK Tyrosine-Protein Kinase; Enzyme Activation; Female; Genistein; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Kisspeptins; Membrane Potentials; Mice; Mice, Transgenic; Neurons; Ovariectomy; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; TRPC Cation Channels; Wortmannin

Topics: Cells, Cultured; Delayed Rectifier Potassium Channels; ErbB Receptors; Genistein; Heart Atria; HEK293 Cells; Humans; Protein Kinase Inhibitors; Pyrimidines; Tyrphostins