ag 1879 and dasatinib

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

Topics: Adenylyl Imidodiphosphate; Animals; Apoenzymes; B-Lymphocytes; Catalytic Domain; Crystallography, X-Ray; Dasatinib; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Mice; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrimidines; src-Family Kinases; Thiazoles

Topics: Animals; Antigens, CD; Antigens, Neoplasm; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Dasatinib; Enzyme Activation; Fluorescent Antibody Technique; HEK293 Cells; Humans; Lung Neoplasms; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Neoplasm Proteins; Pyrimidines; src-Family Kinases; Tandem Mass Spectrometry; Thiazoles; Transplantation, Heterologous

Topics: Animals; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Benzimidazoles; Benzodioxoles; Breast Neoplasms; Cell Death; Cell Line, Transformed; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dasatinib; Female; Fibroblasts; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Protease Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Pyrimidines; Quinazolines; Radiation Tolerance; src-Family Kinases; Thiazoles

Topics: Agammaglobulinaemia Tyrosine Kinase; Binding Sites; Chromosomes, Human, X; Crystallography, X-Ray; Dasatinib; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyrimidines; src-Family Kinases; Thiazoles

Topics: Antineoplastic Agents; Blotting, Western; Cell Cycle; Cell Differentiation; Dasatinib; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Humans; Immunoprecipitation; Leukemia, Myeloid; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-raf; Pyrimidines; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Thiazoles; Tretinoin; Tumor Cells, Cultured

Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; Female; Humans; Indoles; Neoplasm Invasiveness; Paxillin; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Sulfonamides; Thiazoles

Topics: Animals; Carcinoma; Carcinoma, Papillary; Cell Proliferation; Dasatinib; Disease Models, Animal; Indoles; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; src-Family Kinases; Sulfonamides; Thiazoles; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Cells, Cultured

Topics: Adaptor Proteins, Signal Transducing; ADP-ribosyl Cyclase 1; Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Class Ia Phosphatidylinositol 3-Kinase; Dasatinib; HL-60 Cells; Humans; Leukemia, Myeloid; Membrane Glycoproteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-vav; Pyrimidines; src-Family Kinases; Thiazoles; Tretinoin

Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cetuximab; Dasatinib; DNA Replication; Dose Fractionation, Radiation; Female; Humans; Mice; Mice, Nude; Neovascularization, Pathologic; Pyrimidines; ras Proteins; src-Family Kinases; Thiazoles; Tumor Burden; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

Topics: Animals; Apoptosis; Carcinoma; Cell Line, Tumor; Claudins; Dasatinib; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplasm Proteins; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Pyrimidines; RNA Interference; RNA, Messenger; RNA, Neoplasm; Signal Transduction; src-Family Kinases; Transcription Factor AP-1; Transcription, Genetic; Triple Negative Breast Neoplasms

Topics: Animals; Cell Line; Cell Survival; Dasatinib; Dystroglycans; Liver; Male; Mice, Inbred mdx; Muscle Fatigue; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Protein Kinase Inhibitors; Pyrimidines; Reproducibility of Results; src-Family Kinases; Torque

Topics: Animals; Caveolin 1; Cell Line, Tumor; Cell Movement; Cell Survival; Dasatinib; Female; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neuropeptides; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; rac1 GTP-Binding Protein; Skin Neoplasms; src-Family Kinases; Transfection; Tyrosine

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Dasatinib; Disulfiram; Drug Synergism; Humans; Male; Mice; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Xenograft Model Antitumor Assays