ag 1879 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

Topics: Animals; Cells, Cultured; Chromones; Cricetinae; DNA-Binding Proteins; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Granulosa Cells; Janus Kinase 2; Milk Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrphostins

Topics: Acetylcholine; Animals; Barium; Calcium Channels, L-Type; Carbazoles; Cells, Cultured; Chromones; Class Ib Phosphatidylinositol 3-Kinase; Diamines; Enzyme Inhibitors; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Indoles; Ion Channel Gating; Ion Transport; Isoenzymes; Male; Morpholines; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Portal Vein; Protein Kinase C; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Rabbits; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Signal Transduction

Topics: Actins; Amides; Blotting, Western; Breast Neoplasms; Butadienes; Carcinoma; Catalysis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; CSK Tyrosine-Protein Kinase; Culture Media, Serum-Free; Depsipeptides; Down-Regulation; Fibronectins; Flow Cytometry; Humans; Immunoprecipitation; Insulin-Like Growth Factor I; Integrin alpha5beta1; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Models, Biological; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; src-Family Kinases; Time Factors

Topics: Animals; Cell Line; Chromones; Cyclooxygenase 2; Endotoxemia; Flavonoids; Gene Expression Regulation; Genes, src; Lipopolysaccharides; Macrophage Activation; Macrophages; Macrophages, Peritoneal; Mice; Morpholines; NF-kappa B; Nitric Oxide; Peritonitis; Phosphoinositide-3 Kinase Inhibitors; Proline; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Thiocarbamates; Tumor Necrosis Factor-alpha

Topics: Actins; Animals; Binding Sites; Cell Differentiation; Cells, Cultured; Chromones; Cytochalasin D; Cytoskeleton; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred C57BL; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein Transport; Pyrimidines; src-Family Kinases; Time Factors

Topics: Chromones; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Inflammation; Kinetics; Leukocytes; Lipopolysaccharides; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Morpholines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peptidoglycan; Pyridines; Pyrimidines; src-Family Kinases; Staphylococcus aureus; Time Factors

Topics: Animals; Animals, Newborn; Cell Culture Techniques; Cell Extracts; Cells, Cultured; Chromatography, Gel; Chromones; Endothelin-1; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Immunoblotting; Indoles; Maleimides; Morpholines; Myocytes, Cardiac; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C-delta; Pyrimidines; Rats; Rats, Sprague-Dawley; Solubility; Tetradecanoylphorbol Acetate; Time Factors

Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antibodies; Blastocyst; Cell Proliferation; Cells, Cultured; Chromones; Cross-Linking Reagents; Dose-Response Relationship, Drug; Female; Histocompatibility Antigens Class I; Immunoglobulins; Immunoprecipitation; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Nucleosides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fyn; Pyridazines; Pyrimidines; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin

Topics: Animals; Caveolin 1; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Chromones; Embryonic Stem Cells; Estradiol; Estrogen Antagonists; Fulvestrant; MAP Kinase Signaling System; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; RNA, Small Interfering; src-Family Kinases

Topics: Animals; Apoptosis; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Insulin-Like Growth Factor I; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Rats; Reproductive Control Agents; src-Family Kinases

Topics: Acetophenones; Benzopyrans; Butadienes; Chromones; Gene Expression Regulation, Enzymologic; Genistein; Hexosaminidases; Humans; Imidazoles; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Messenger; Tyrphostins

Topics: Cell Movement; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors; Estrenes; Focal Adhesion Kinase 2; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Morpholines; Neovascularization, Physiologic; Oxytocin; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrrolidinones; Receptors, Oxytocin; RNA, Small Interfering; Signal Transduction; Sphingosine; src-Family Kinases; Type C Phospholipases; Umbilical Veins; Vascular Endothelial Growth Factor A

Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Antibodies; Binding Sites; CD3 Complex; Cell Line; Cell Movement; Cell Polarity; Cells, Cultured; Chromones; Enzyme Inhibitors; Green Fluorescent Proteins; Intercellular Adhesion Molecule-1; Interleukin-2; Lymphocyte Function-Associated Antigen-1; Mice; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Pyrimidines; rho GTP-Binding Proteins; Signal Transduction; src-Family Kinases; T-Lymphocytes

Topics: 4-1BB Ligand; Animals; Carrier Proteins; Cell Adhesion; Cell Line; Cell Survival; Chromones; Cytokines; Enzyme Inhibitors; Immunity, Innate; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Inbred BALB C; Morpholines; Myeloid Cells; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyrimidines; Recombinant Proteins; Signal Transduction; Sirolimus; src-Family Kinases; TOR Serine-Threonine Kinases; Tumor Necrosis Factor Receptor Superfamily, Member 9

Topics: Animals; Cell Count; Chromones; Embryo, Mammalian; Extracellular Matrix; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; GPI-Linked Proteins; Membrane Glycoproteins; Mice; Morpholines; NIH 3T3 Cells; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Quinolones; Serum; src-Family Kinases; Sulfones; Up-Regulation

Topics: 3T3-L1 Cells; Animals; Antineoplastic Agents, Phytogenic; Chromones; Drug Interactions; Enzyme Activation; Flavonoids; Free Radical Scavengers; Mice; Mitogen-Activated Protein Kinase 1; Morpholines; Naphthoquinones; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Pyrimidines; src-Family Kinases; Superoxides

Topics: Actins; Androstadienes; Animals; Bacillus anthracis; Blotting, Western; Cell Line; Cell Survival; Chromones; CSK Tyrosine-Protein Kinase; Epithelial Cells; HeLa Cells; Humans; Indoles; Mice; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; RNA, Small Interfering; Spores, Bacterial; src-Family Kinases; Sulfonamides; Wortmannin

Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Inhibitors; ErbB Receptors; Estrogen Receptor alpha; Estrogens; Feedback, Physiological; Female; Humans; Mice; Mice, Nude; Morpholines; Ovariectomy; Pyrimidines; RNA, Small Interfering; Shc Signaling Adaptor Proteins; src-Family Kinases

Topics: Amides; Cell Movement; Cells, Cultured; Chemotaxis; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organophosphonates; Protein Folding; Pyridines; Pyrimidines; Signal Transduction; Thrombospondin 1

Topics: Active Transport, Cell Nucleus; Blotting, Western; Cell Adhesion; Cells, Cultured; Chromones; Coculture Techniques; Dose-Response Relationship, Drug; E-Selectin; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Mechanotransduction, Cellular; Monocytes; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; RNA Interference; src-Family Kinases; Stress, Mechanical; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor Receptor-2

Topics: Butadienes; C-Peptide; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Glomerular Mesangium; Humans; MAP Kinase Signaling System; Mesangial Cells; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyrimidines; Retinoblastoma Protein; src-Family Kinases

Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cerebral Cortex; Chromones; Embryo, Mammalian; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Glutamic Acid; Indole Alkaloids; Morpholines; Neurons; Phospholipase C gamma; Phosphorylation; Primary Cell Culture; Pyrimidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; src-Family Kinases

Topics: Animals; Cell Line; Chromones; Hydrocarbons, Fluorinated; Hydroxycholesterols; Liver X Receptors; Macrophages; Morpholines; Orphan Nuclear Receptors; Pertussis Toxin; Plaque, Atherosclerotic; Pyrimidines; Sulfonamides; Transcription, Genetic; Tumor Necrosis Factor-alpha

Topics: Animals; Cadaverine; Cell Survival; Chromones; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Fibroblasts; GTP-Binding Proteins; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Morpholines; Multiprotein Complexes; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Glutamine gamma Glutamyltransferase 2; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; src-Family Kinases; TOR Serine-Threonine Kinases; Transglutaminases

Topics: Animals; Butadienes; Chromones; Ciliary Body; Enzyme Activation; Epithelium; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds, 3-Ring; Imidazoles; Insulin; Models, Biological; Morpholines; Nitriles; Ouabain; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pigmentation; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Rubidium; Signal Transduction; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Sus scrofa; Time Factors

Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Chromones; Disease Models, Animal; Ephrin-B1; Excitatory Amino Acid Agents; Glaucoma; Glial Fibrillary Acidic Protein; Intercellular Signaling Peptides and Proteins; Male; Morpholines; Phenols; Piperidines; Proline; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Eph Family; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha