aflatoxin b1 has been researched along with benzo(a)pyrene in 118 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 39 (33.05) | 18.7374 |
1990's | 48 (40.68) | 18.2507 |
2000's | 12 (10.17) | 29.6817 |
2010's | 16 (13.56) | 24.3611 |
2020's | 3 (2.54) | 2.80 |
Authors | Studies |
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Butterworth, BE; Eldridge, SR; Gould, MN | 1 |
Linko, P; Liu, YH; Lucier, GW; Taylor, J; Thompson, CL | 1 |
Nath, J; Ong, TM; Warner, JR | 1 |
Abraham, SK | 1 |
Lee, MS; Wang, CY; Zukowski, K | 1 |
Said, B; Shank, RC | 1 |
Bauchinger, M; Kulka, U; Paul, D; Salassidis, K; Schmid, E | 1 |
Paumgartten, FJ; Röscheisen, C; Speit, G; Zamith, H | 1 |
Groopman, J; Lim, S; Ozturk, M; Puisieux, A | 1 |
Ersing, N; Faletto, MB; Gurtoo, HL; Kouli, F; Maccubbin, AE; Vangalio, JA | 1 |
Rubano, DC; Strother, A; Teel, RW | 1 |
Friederich, U; Grüter, A; Würgler, FE | 1 |
Busbee, DL; Norman, JO; Ziprin, RL | 1 |
Arlotto, MP; Crespi, CL; Davies, RL; Leakey, JA; Parkinson, A; Penman, BW; Rudo, K; Stark, A; Steimel, DT; Turner, T | 1 |
Cassand, P; Colin, C; Daubeze, M; Leveque, F; Narbonne, JF | 1 |
Cassand, P; Decoudu, S; Leveque, F; Narbonne, JF | 1 |
Dutcher, JS; Henderson, TR; Howard, AJ; McClellan, RO; Mitchell, CE | 1 |
Athar, M; Bickers, DR; Cheng, SJ; Khan, WA; Mukhtar, H; Wang, ZY; Zhou, ZC | 1 |
Faletto, MB; Gurtoo, HL; Koser, PL; Maccubbin, AE; Vangalio, JA | 1 |
Dvorackova, I; Garner, RC; Tursi, F | 1 |
Gurtoo, HL; Raina, V | 1 |
Al-Sabti, K | 1 |
Carluccio, MA; Gemperlein, I; Glatt, HR; Oesch, F; Turchi, G | 1 |
Armel, P; Williams, GM | 1 |
Würgler, FE | 1 |
Huang, CC; Qin, S | 1 |
Bjeldanes, LF; Hendrich, S | 1 |
Harris, CC; Hsu, IC; Lipsky, MM; Snyder, S; Trump, BF | 1 |
Chen, XR; Sun, L; Yu, YN | 1 |
Combes, RD; Walters, JM | 1 |
Bakke, JP; Green, CE; Mirsalis, JC; Spak, DK; Steinmetz, KL | 1 |
Felton, JS; Fuscoe, JC; Healy, SK; Shen, NH; Wu, R | 1 |
Fukuhara, M; Ohno, Y; Sunouchi, M; Takanaka, A | 1 |
Black, JJ; Maccubbin, AE; Schiffert, M | 1 |
Gurtoo, HL; Koser, P; Raina, V | 1 |
Jones, PA; Wilson, VL | 1 |
Autrup, H; Essigmann, JM; Harris, CC; Schwartz, RD; Smith, L; Trump, BF | 1 |
Cortesi, E; Donovan, PJ; Kakunaga, T; Rice, JM; Saffiotti, U | 1 |
Collins, MA; Cottrell, RC; Gangolli, SD; Harris, RA; Lake, BG; Phillips, JC; Rowland, IR | 1 |
Curtis, G; Garland, H; Nesnow, S | 1 |
Huh, N; Nemoto, N; Utakoji, T | 1 |
Gould, MN | 1 |
Akintonwa, DA | 1 |
Loquet, C; Wiebel, FJ | 1 |
Goldstein, JA; Robertson, IG; Zeiger, E | 1 |
Hsia, MT | 1 |
Heidelberger, C; Landolph, JR; Link, KH | 1 |
Friesen, E; Israels, ED; Israels, LG; Ollmann, DJ; Walls, GA | 1 |
Baker, RS; Meher-Homji, KM; Mitchell, GA; Podobna, E | 1 |
Choe, SY; Kim, DH; Shin, CG; Yang, KH | 1 |
Autrup, H; Bao, LY; Harris, CC; Hsia, CC; Lu, S; Pei, XF; Sun, TT; Wu, SM | 1 |
Avadhani, NG; Jefcoate, CR; Niranjan, BG; Wilson, NM | 1 |
Hall, SD; Lee, AM; Murison, GL | 1 |
Den Engelse, L; Kriek, E; Scherer, E; Westra, JG | 1 |
Hopkin, JM | 1 |
Bagnasco, M; Bennicelli, C; Bojnemirski, A; Camoirano, A; De Flora, S; Kurelec, B | 1 |
Chou, MW; Chung, KT; Hart, RW; Kong, J | 1 |
Borgerding, MF; Chang, KM; Doolittle, DJ; Fulp, C; Lee, CK; Munoz, JA; Rogers, JC | 1 |
Itahashi, K; Kamataki, T; Kato, T; Kitada, M; Nakasa, H; Ohmori, S; Rikihisa, T; Shimada, T | 1 |
al-Maskati, HA; Dairi, MG; el-Din, AY; Mohamed, AY | 1 |
Casciano, DA; Chou, MW; Hart, RW; Kong, J; Shaddock, JG | 1 |
Abdelali, H; Bouley, C; Cassand, P; Denariaz, G; Narbonne, JF | 1 |
Ball, RW; Coulombe, RA; Huie, JM | 1 |
Aleixandre, V; Blanco, M; Herrera, G; Sommer, S; Urios, A | 1 |
Montague, W; Raza, H | 1 |
Itoh, S; Kamataki, T; Sawada, M; Tagawa, S | 1 |
Crutzen-Fayt, MC; Gerber, GB; Hilali, A; Léonard, A | 1 |
Bauchinger, M; Doehmer, J; Glatt, HR; Kulka, U | 1 |
Kelly, MD; Park, BK; Tingle, MD; Wilson, AS | 1 |
al-Dakan, AA; al-Tuffail, M; Hannan, MA | 1 |
Bruijntjes-Rozier, GC; Evertz, SJ; Rompelberg, CJ; van den Heuvel, PD; Verhagen, H | 1 |
Dauterman, WC; DeMarini, DM; Woodall, GM | 2 |
Galloway, SM; Johnson, TE; Umbenhauer, DR | 1 |
Nash, RA | 1 |
Choi, MJ; Lee, BM; Lee, JW | 1 |
Horský, J; Pitha, J | 1 |
Duh, PD; Yen, GC | 1 |
Crespi, CL; Penman, BW; Smith, T; Steimel, DT; Sutter, TR; Yang, CS | 1 |
Chen, W; Chou, MW; Chung, KT; Hart, RW; Jackson, CD; Mikhailova, MV; Nichols, J; Weis, C | 1 |
Kranendonk, M; Laires, A; Mesquita, P; Rueff, J; Vermeulen, NP | 1 |
Kusamran, WR; Ratanavila, A; Tepsuwan, A | 1 |
Adav, SS; Govindwar, SP | 1 |
Harris, CC; Hussain, SP | 1 |
Hengstler, JG; Oesch, F; Steinberg, P; Van der Burg, B | 1 |
Monti, R; Tavares, DC; Varanda, EA | 1 |
Athar, M; Raisuddin, S; Sharma, N; Trikha, P | 1 |
Fujita, K; Kamataki, T; Muto, S; Yamazaki, Y | 1 |
de Boer, JG | 1 |
Chen, CF; Liao, JF; Lin, YL; Liu, TY; Oda, Y; Shyu, CC; Ueng, YF | 1 |
Cavin, C; Constable, A; Holzhaeuser, D; Huber, WW; Scharf, G; Schilter, B | 1 |
Ajith, TA; Joseph, S; Kuttan, R; Raphael, KR | 1 |
Fu, J; Jiang, X; Li, H; Qi, J | 1 |
Arimoto-Kobayashi, S; Fujita, K; Kamataki, T; Negishi, T; Okamoto, K; Takahashi, E | 1 |
Dávila, VM; Ito, A; Montero, R; Plancarte, A; Serrano, L | 1 |
Jin, Y; Xu, Z | 1 |
Biso, FI; Cardoso, CR; Longo, Mdo C; Nogueira, ME; Passoni, MH; Santos, LC; Varanda, EA | 1 |
Byun, SH; Kim, HS; Lee, BM | 1 |
Chen, L; Chen, W; Ji, W; Lai, Y; Li, D; Li, W; Lin, Y; Ma, R; Pang, Y; Tang, S; Wang, Q; Wei, Q; Xiao, Y; Yang, P; Zheng, Y; Zhuang, Z | 1 |
Angeli, JP; Barbosa, F; Barcelos, GR; Mantovani, MS; Nersesyan, A; Serpeloni, JM | 1 |
Boyd, WA; Freedman, JH; Goldstone, JV; Leung, MC; Meyer, JN | 1 |
Callegari, E; Elamin, BK; Gramantieri, L; Negrini, M; Sabbioni, S | 1 |
André, V; Billet, S; Garçon, G; Goff, JL; Lechevrel, M; Paget, V; Pottier, D; Shirali, P; Sichel, F | 1 |
Fessard, V; Huet, S; Le Hégarat, L | 1 |
Chesné, C; Claessen, SM; Jetten, MJ; Kleinjans, JC; van Delft, JH | 1 |
Castell, JV; Claessen, SM; Dejong, CH; Jetten, MJ; Kleinjans, JC; Lahoz, A; van Delft, JH | 1 |
Aubrecht, J; Buick, JK; Fornace, AJ; Hyduke, DR; Li, HH; Moffat, I; Recio, L; Swartz, CD; Williams, A; Yauk, CL | 1 |
Audebert, M; Glaise, D; Loyer, P; Martinais, S; Morel, F; Quesnot, N; Robin, MA; Rondel, K | 1 |
Beland, FA; Marrone, AK; Pogribny, IP; Tryndyak, V | 1 |
Jennen, DGJ; Kleinjans, JCS; Smit, E; Souza, T; van den Beucken, T | 1 |
Ferk, F; Filipič, M; Haas, O; Haslinger, E; Huber, WW; Knasmüller, S; Mai, S; Mikulits, W; Mišík, M; Tomc, J; Waldherr, M; Žegura, B | 1 |
Breznik, B; Filipič, M; Kamenšek, U; Kološa, K; Tomc, J; Turnšek, TL; Žegura, B | 1 |
Beland, FA; Churchwell, MI; Dreval, K; Kindrat, I; Pogribny, IP; Tryndyak, V | 1 |
Cao, Y; Chen, R; Han, L; Liu, W; Luan, Y; Pan, G; Xi, J; You, X; Zhang, X | 1 |
Auerbach, SS; Bushel, PR; DeVito, MJ; Dunlap, PE; Ferguson, SS; Merrick, BA; Paules, RS; Ramaiahgari, SC; Rice, JR; Saddler, TO; Shah, RR; Sipes, NS | 1 |
Chen, Y; Hu, K; Li, Z; Liu, Y; Zhu, N | 1 |
Carpi, D; Lloyd, GR; Malinowska, JM; Palosaari, T; Sund, J; Viant, MR; Weber, RJM; Whelan, M | 1 |
Guan, X; Li, W; Lv, Y; Sun, Y; Wang, Y; Wu, Y; Yu, M | 1 |
8 review(s) available for aflatoxin b1 and benzo(a)pyrene
Article | Year |
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Toxicological significance of dihydrodiol metabolites.
Topics: Aflatoxin B1; Aflatoxins; Alcohols; Aldrin; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Chemical Phenomena; Chemistry; Cricetinae; Environmental Pollutants; Insecticides; Mutagenicity Tests; Pesticide Residues; Rats; Structure-Activity Relationship | 1982 |
Formation of DNA modifications by chemical carcinogens. Identification, localization and quantification.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antibodies; Antibodies, Monoclonal; Benzo(a)pyrene; Blood-Brain Barrier; Blood-Testis Barrier; Carcinogens; Cyclophosphamide; DNA; DNA, Single-Stranded; Ethylnitrosourea; Female; Guanine; Histocytochemistry; Humans; Liver; Male; Nucleic Acid Conformation; Respiratory System; Spectrometry, Fluorescence; Tissue Distribution | 1984 |
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer.
Topics: Aflatoxin B1; Benzo(a)pyrene; Carcinogens; Carcinogens, Environmental; Codon; Genes, p53; Humans; Models, Biological; Mutation; Neoplasms; Nitric Oxide; Sunlight | 1999 |
Interspecies differences in cancer susceptibility and toxicity.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents, Hormonal; Benzo(a)pyrene; Cardiotonic Agents; Cricetinae; Digitoxin; Disease Susceptibility; Endocrine System; Estrogens; Female; Heterocyclic Compounds; Humans; Male; Mice; Microsomes, Liver; Neoplasms; Polychlorinated Dibenzodioxins; Rabbits; Rats; Species Specificity; Tamoxifen | 1999 |
Protection by dietary compounds against mutation in a transgenic rodent.
Topics: Aflatoxin B1; Animals; Animals, Genetically Modified; Bacterial Proteins; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Escherichia coli Proteins; Humans; Imidazoles; Lac Repressors; Mice; Mutagenesis; Mutagens; Mutation; Neoplasms; Rats; Repressor Proteins; Sex Characteristics; Species Specificity | 2001 |
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Cells, Cultured; Coffee; Colorectal Neoplasms; Disease Models, Animal; Diterpenes; Enzyme Induction; Humans; Imidazoles | 2002 |
[Environmental carcinogens and p53 gene mutation].
Topics: Aflatoxin B1; Animals; Benzo(a)pyrene; Carcinogens, Environmental; Genes, p53; Humans; Mutation; Neoplasms; Tumor Suppressor Protein p53 | 2004 |
MicroRNA response to environmental mutagens in liver.
Topics: Aflatoxin B1; Animals; Arsenic; Benzo(a)pyrene; Carcinoma, Hepatocellular; Environmental Pollutants; Ethanol; Gene Expression Regulation; Hepacivirus; Hepatitis B virus; Humans; Liver; Liver Neoplasms; MicroRNAs; Mutagens; Nicotiana; Poisons; Risk Factors; Rodenticides; Triazines | 2011 |
110 other study(ies) available for aflatoxin b1 and benzo(a)pyrene
Article | Year |
---|---|
Genotoxicity of environmental agents in human mammary epithelial cells.
Topics: 2-Acetylaminofluorene; Adult; Aflatoxin B1; Benzo(a)pyrene; Breast; DNA Repair; DNA, Neoplasm; Environmental Pollutants; Epithelial Cells; Epithelium; Female; Humans; Mutagenicity Tests; Pyrenes | 1992 |
Glutathione S-transferase mu in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts.
Topics: Adolescent; Adult; Aflatoxin B1; Aged; Aged, 80 and over; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chromatography, High Pressure Liquid; Cytosol; Dinitrochlorobenzene; DNA; Female; Glutathione Transferase; Humans; Liver; Liver Neoplasms; Lymphocytes; Male; Middle Aged; Polymorphism, Genetic; Pyrimidines; Stilbenes | 1991 |
Antimutagenicity studies of chlorophyllin using the Salmonella arabinose-resistant assay system.
Topics: Aflatoxin B1; Aflatoxins; Air Pollutants; Anthracenes; Benzo(a)pyrene; Carcinogens; Chlorophyllides; Coal; DNA; Dose-Response Relationship, Drug; Fossil Fuels; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutation; Plants, Toxic; Salmonella typhimurium; Tobacco, Smokeless; Wine | 1991 |
Inhibitory effects of coffee on the genotoxicity of carcinogens in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Bone Marrow; Carcinogens; Coffee; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Mutation; Urethane | 1991 |
Inhibition by diacylmethane derivatives of mutagenicity in Salmonella typhimurium and tRNA-binding of chemical carcinogens.
Topics: Aflatoxin B1; Aflatoxins; Benzo(a)pyrene; Benzoates; Butanones; Carcinogens; Chalcones; Dose-Response Relationship, Drug; Hydroxylamines; Indans; Methane; Methylnitrosourea; Mutagens; Pentanones | 1991 |
Nearest neighbor effects on carcinogen binding to guanine runs in DNA.
Topics: Aflatoxin B1; Aflatoxins; Autoradiography; Base Sequence; Benzo(a)pyrene; Binding, Competitive; Carcinogens; DNA; Electrophoresis, Agar Gel; Guanine; Hydrogen-Ion Concentration; Hydrolysis; Lomustine; Methylnitrosourea; Molecular Sequence Data; Photochemistry; Plasmids | 1991 |
Induction of chromosome aberrations and sister chromatid exchange by indirectly acting mutagens in immortal mouse and rat hepatocyte lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Chromosome Aberrations; Cyclophosphamide; Liver; Mice; Mutagenicity Tests; Mutagens; Rats; Sister Chromatid Exchange | 1991 |
Influence of beta-myrcene on sister-chromatid exchanges induced by mutagens in V79 and HTC cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acyclic Monoterpenes; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Cricetinae; Cricetulus; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Monoterpenes; Mutagens; Sister Chromatid Exchange; Terpenes | 1991 |
Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.
Topics: Aflatoxin B1; Base Sequence; Benzo(a)pyrene; DNA; DNA Fingerprinting; Genes, p53; Humans; Molecular Sequence Data; Mutation; Neoplasms | 1991 |
Altered benzo[a]pyrene metabolism in C3H/10T1/2 cells transformed by aflatoxin B1 or 3-methylcholanthrene.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; DNA; DNA Adducts; gamma-Glutamyltransferase; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Methylcholanthrene | 1990 |
Effect of glucose administration on hamster liver S9-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Cricetinae; DNA; DNA Damage; Glucose; Glucuronates; Glutathione; Liver; Male; Microsomes, Liver; Mutagenicity Tests; Mutation; Sulfates | 1990 |
Antimutagenic effects of mushrooms.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxin B1; Aflatoxins; Aminacrine; Basidiomycota; Benzo(a)pyrene; DNA Repair; Ethanol; Fluorenes; Hot Temperature; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutation; Nitrogen Mustard Compounds | 1990 |
Comparative uptake, vascular transport, and cellular internalization of aflatoxin-B1 and benzo(a)pyrene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biological Transport; Body Fluids; Carcinogens; Digestive System; Fibroblasts; Intracellular Fluid; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Lymph; Molecular Weight; Palmitates; Sheep; Thoracic Duct | 1990 |
Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.
Topics: Aflatoxin B1; Aflatoxins; Base Sequence; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; DNA; Humans; Molecular Sequence Data; Mutagens | 1990 |
Chemical mutagenicity and cellular status in vitamins A, E and C.
Topics: Aflatoxin B1; Aflatoxins; Animals; Ascorbic Acid; Benzo(a)pyrene; Injections, Intraperitoneal; Male; Microsomes, Liver; Mutagenicity Tests; Rats; Rats, Inbred Strains; Salmonella typhimurium; Vitamin A; Vitamin E | 1990 |
Relationship between vitamin A dietary intake and mutagenic activity of some chemical carcinogens.
Topics: 2-Acetylaminofluorene; Administration, Oral; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Dose-Response Relationship, Drug; Drug Interactions; Liver; Male; Mutagenicity Tests; Rats; Rats, Inbred Strains; Salmonella typhimurium; Vitamin A | 1990 |
Binding of nitropyrenes and benzo[a]pyrene to mouse lung deoxyribonucleic acid after pretreatment with inducing agents.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; DNA; Lung; Male; Methylene Chloride; Mice; Pyrenes; Vehicle Emissions | 1986 |
Antimutagenic activity of green tea polyphenols.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Chromosome Aberrations; Cricetinae; DNA Damage; Flavonoids; Free Radicals; Microsomes; Mutagenicity Tests; Mutagens; Nitroso Compounds; Phenols; Polymers; Polyphenols; Sister Chromatid Exchange; Tea | 1989 |
Induction of aryl hydrocarbon hydroxylase and DNA adduct formation in parental and carcinogen transformed C3H/10T1/2 clone 8 cells by benzo[a]pyrene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; Enzyme Induction; Fibroblasts; Male; Mice; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains | 1989 |
Immunoassay procedures to detect exposure to aflatoxin B1 and benzo(a)pyrene in animals and man at the DNA level.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; DNA; Enzyme-Linked Immunosorbent Assay; Humans; Liver; Liver Neoplasms; Lung; Male; Rats; Rats, Inbred Strains | 1988 |
Effects of vitamins A, C, and E on aflatoxin B1-induced mutagenesis in Salmonella typhimurium TA-98 and TA-100.
Topics: Aflatoxin B1; Aflatoxins; Animals; Ascorbic Acid; Benzo(a)pyrene; Biotransformation; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Tretinoin; Vitamin A; Vitamin E; Vitamin K | 1985 |
Carcinogenic-mutagenic chemicals induced chromosomal aberrations in the kidney cells of three cyprinids.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aroclors; Benzidines; Benzo(a)pyrene; Carcinogens; Chlorodiphenyl (54% Chlorine); Chromosome Aberrations; Cyprinidae; Kidney; Methylcholanthrene; Mutagens; Species Specificity | 1985 |
Characterization of an epithelial, nearly diploid liver cell strain, from Chinese hamster, able to activate promutagens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Cell Division; Cells, Cultured; Clone Cells; Cricetinae; Cricetulus; Epithelial Cells; Epithelium; Karyotyping; Liver; Mutagens; Pyruvate Kinase; Tyrosine Transaminase | 1987 |
The molecular nature of spontaneous and chemically induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene in rat liver epithelial cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Blotting, Southern; Cell Line; DNA Probes; Epithelium; Hypoxanthine Phosphoribosyltransferase; Liver; Mutation; Polymorphism, Restriction Fragment Length; Rats | 1988 |
Polysubstrate monooxygenases in Drosophila, mammals and man.
Topics: Aflatoxin B1; Aflatoxins; Aldrin; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Drosophila; Drug Resistance; Enzyme Induction; Humans; Insecticides; Mice; Mutagens; Nitrosamines; Oxygenases; Receptors, Aryl Hydrocarbon; Receptors, Drug; Species Specificity | 1985 |
Influence of mouse liver stored vitamin A on the induction of mutations (Ames tests) and SCE of bone marrow cells by aflatoxin B1, benzo(a)pyrene, or cyclophosphamide.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cyclophosphamide; Liver; Male; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Mutation; Sister Chromatid Exchange; Vitamin A; Vitamin A Deficiency | 1986 |
Effects of dietary Schizandra chinensis, brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver.
Topics: 7-Alkoxycoumarin O-Dealkylase; Administration, Oral; Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Cytosol; Drug Interactions; Epoxide Hydrolases; Female; Glutathione; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mutagens; Oxygenases; Plant Extracts; Salmonella typhimurium; Sex Factors; Vegetables | 1986 |
Cell and species differences in metabolic activation of chemical carcinogens.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Cricetinae; Cricetulus; Dimethylnitrosamine; DNA Damage; Fibroblasts; Humans; Liver; Lung; Macrophages; Male; Mice; Mutation; Rats; Species Specificity | 1987 |
A test using cultured cells with induced mixed-function oxygenase in the unscheduled DNA synthesis assay for detecting promutagens/procarcinogens.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; DNA Damage; DNA Repair; Enzyme Induction; Humans; Methylcholanthrene; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens | 1987 |
Activation of benzo[a]pyrene and aflatoxin B1 to mutagenic chemical species by microsomal preparations from rat liver and small intestine in relation to microsomal epoxide hydrolase.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Epoxide Hydrolases; Hydrocarbons, Chlorinated; Intestine, Small; Microsomes; Microsomes, Liver; Mutagens; Rats; Trichloroepoxypropane | 1986 |
Induction of unscheduled DNA synthesis in primary cultures of rat, mouse, hamster, monkey, and human hepatocytes.
Topics: 2-Acetylaminofluorene; Adult; Aflatoxin B1; Aflatoxins; Aminobiphenyl Compounds; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cricetinae; Dimethyl Sulfoxide; DNA; DNA Repair; Female; Haplorhini; Humans; Liver; Male; Mice; Rats; Species Specificity | 1988 |
Base-change analysis of revertants of the hisD3052 allele in Salmonella typhimurium.
Topics: Aflatoxin B1; Aflatoxins; Base Composition; Base Sequence; Benzo(a)pyrene; Carcinogens; Cloning, Molecular; DNA, Bacterial; Food; Histidine; Imidazoles; Molecular Sequence Data; Mutagens; Operon; Quinolines; Salmonella typhimurium | 1988 |
Effects of various inducers on the activities of cytochrome P-450-mixed function oxidases and aflatoxin B1 activation in microsomes of hamster livers.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzoflavones; Biotransformation; Cricetinae; DNA; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases | 1988 |
A reliable, efficient, microinjection apparatus and methodology for the in vivo exposure of rainbow trout and salmon embryos to chemical carcinogens.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Dimethyl Sulfoxide; Dimethylnitrosamine; Methylnitronitrosoguanidine; Microinjections; Mutagenicity Tests; Salmon; Trout | 1985 |
Differential sensitivity of Ah-responsive mice to beta-naphthoflavone-induced metabolism and mutagenesis of benzo[a]pyrene and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxin M1; Aflatoxins; Animals; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Drug Interactions; Female; Flavonoids; Mice; Mice, Inbred C57BL; Microsomes, Liver | 1985 |
Chemical carcinogen-mediated decreases in DNA 5-methylcytosine content of BALB/3T3 cells.
Topics: 5-Methylcytosine; Aflatoxin B1; Aflatoxins; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Fibroblasts; In Vitro Techniques; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phenanthrenes | 1984 |
Metabolism of aflatoxin B1, benzo[a]pyrene, and 1,2-dimethylhydrazine by cultured rat and human colon.
Topics: 1,2-Dimethylhydrazine; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Colon; Dimethylhydrazines; DNA; Humans; Male; Methylhydrazines; Organ Culture Techniques; Rats | 1980 |
Dose-response studies on neoplastic transformation of BALB/3T3 clone A31-1-1 cells by aflatoxin B1, benzidine, benzo[a]pyrene, 3-methylcholanthrene, and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzidines; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C | 1983 |
The effect of substrates and inhibitors of monoamine oxidase on hepatic dimethylnitrosamine metabolism and mutagenicity.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Dimethylnitrosamine; Microsomes, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutagenicity Tests; Mutation; Rats; Salmonella typhimurium | 1981 |
Improved transformation of C3H10T1/2CL8 cells by direct- and indirect-acting carcinogens.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Methylnitronitrosoguanidine; Mice; Probability | 1982 |
Metabolic activation of benzo[a]pyrene, aflatoxin B1, and dimethylnitrosamine by a human hepatoma cell line.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Dimethylnitrosamine; Humans; Liver Neoplasms; Middle Aged; Sister Chromatid Exchange | 1982 |
Chemical carcinogen activation in the rat mammary gland: intra-organ cell specificity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Organ Specificity; Rats; Rats, Inbred Strains | 1982 |
Some aspects of the human carcinogenicity of aflatoxin B1 and 3, 4 benz [a] pyrene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Humans; Liver Neoplasms; Mice; Rats | 1982 |
Geno- and cytotoxicity of nitrosamines, aflatoxin B1, and benzo[a]-pyrene in continuous cultures of rat hepatoma cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Survival; Clone Cells; Dexamethasone; Diethylnitrosamine; Dimethylnitrosamine; Ethylnitrosourea; Kinetics; Liver Neoplasms, Experimental; Methylnitronitrosoguanidine; Mutation; Nitrosamines; Rats | 1982 |
Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Amines; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isoenzymes; Mixed Function Oxygenases; Mutagens; NADP; Rats; Salmonella typhimurium | 1983 |
Induction of ouabain-resistant mutants by chemical carcinogens in rat prostate epithelial cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cells, Cultured; Drug Resistance; Epithelium; Male; Methylazoxymethanol Acetate; Methylnitronitrosoguanidine; Mutation; Ouabain; Prostate; Rats; Rats, Inbred F344 | 1983 |
Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Female; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Mutagenicity Tests; Mutation; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Vitamin K; Vitamin K 1; Vitamin K 3; Vitamin K Deficiency | 1983 |
Sensitivity of two Chinese hamster cell lines to SCE induction by a variety of chemical mutagens.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; Lung; Microsomes, Liver; Mutagenicity Tests; Mutagens; Ovary; Sister Chromatid Exchange; Time Factors | 1983 |
Detection of DNA single-strand breaks induced by procarcinogens in Chinese hamster ovary cells cocultured with rat hepatocytes.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Chromosomes; Cricetinae; Cricetulus; DNA, Single-Stranded; Female; Liver; Male; Ovary; Rats; Rats, Inbred Strains; Tritium | 1984 |
Activation of chemical carcinogens by cultured human fetal liver, esophagus and stomach.
Topics: Aflatoxin B1; Aflatoxins; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Culture Techniques; DNA; Esophagus; Female; Gestational Age; Humans; Liver; Male; Nitrosamines; Pregnancy; Stomach | 1984 |
Hepatic mitochondrial cytochrome P-450 system. Distinctive features of cytochrome P-450 involved in the activation of aflatoxin B1 and benzo(a)pyrene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Kinetics; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Inbred Strains; Tritium | 1984 |
Metabolic activation of procarcinogens to genotoxic products in cultured rat liver cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Survival; Cyclophosphamide; Liver; Liver Neoplasms, Experimental; Rats; Sister Chromatid Exchange | 1984 |
Sister chromatid exchange induction by cigarette smoke.
Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Cells, Cultured; Cricetinae; Female; Humans; Lung Neoplasms; Lymphocytes; Male; Mutagenicity Tests; Nicotiana; Plants, Toxic; Sister Chromatid Exchange; Smoke; Smoking | 1984 |
Biotransformation of genotoxic agents in marine sponges. Mechanisms and modulation.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Benzo(a)pyrene; Biotransformation; Carbolines; Glutathione; Glutathione Disulfide; Glutathione Transferase; Inactivation, Metabolic; Microsomes, Liver; Mutagens; Porifera; Quinolines; Rats; Salmonella typhimurium; Species Specificity; Vincristine | 1995 |
Effect of caloric restriction on the metabolic activation of xenobiotics.
Topics: Aflatoxin B1; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; DNA Damage; Energy Intake; Liver; Male; Rats; Rats, Inbred F344; Xenobiotics | 1993 |
Inhibitory activity of cigarette-smoke condensate on the mutagenicity of heterocyclic amines.
Topics: Aflatoxin B1; Amines; Antimutagenic Agents; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Heterocyclic Compounds; Mutagenicity Tests; Nicotiana; Plants, Toxic; Smoke | 1994 |
Possible occurrence of P450 related to P450 HFLb in extrahepatic tissues of human fetuses and its contribution to metabolic activation of promutagens.
Topics: Adrenal Glands; Aflatoxin B1; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Fetus; Humans; Kidney; Liver; Lung; Mutagens; Quinolines | 1994 |
Acrylamide as an inducer of metabolic activation system (S9) in rats.
Topics: 2-Acetylaminofluorene; Acrylamide; Acrylamides; Aflatoxin B1; Animals; Azides; Benzo(a)pyrene; Biotransformation; Dose-Response Relationship, Drug; Liver; Mutagenicity Tests; Mutagens; Rats; Salmonella typhimurium; Sodium Azide | 1993 |
Effect of dietary restriction on partial hepatectomy-induced liver regeneration of aged F344 rats.
Topics: Aflatoxin B1; Aging; Animals; Benzo(a)pyrene; Biotransformation; Body Weight; Cell Division; DNA; DNA Damage; Energy Intake; Hepatectomy; Liver; Liver Regeneration; Male; Organ Size; Rats; Rats, Inbred F344 | 1995 |
Inhibitory effect of dairy products on the mutagenicities of chemicals and dietary mutagens.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxin B1; Animals; Antimutagenic Agents; Benzo(a)pyrene; Bifidobacterium; Cattle; Female; Fluorenes; In Vitro Techniques; Lactobacillus; Male; Milk; Mutagenicity Tests; Quercetin; Rats; Rats, Sprague-Dawley; Salmonella typhimurium | 1994 |
Comparative activation of aflatoxin B1 by mammalian pulmonary tissues.
Topics: Aflatoxin B1; Animals; Benzo(a)pyrene; Biotransformation; Cricetinae; Cytochrome P-450 Enzyme System; In Vitro Techniques; Liver; Lung; Mesocricetus; Organ Specificity; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Subcellular Fractions; Trachea | 1995 |
Mutability of Salmonella tester strains TA1538 (hisD3052) and TA1535 (hisG46) containing the UmuD' and UmuC proteins of Escherichia coli.
Topics: Aflatoxin B1; Bacterial Proteins; Benzo(a)pyrene; Biotransformation; DNA-Directed DNA Polymerase; Escherichia coli; Escherichia coli Proteins; Frameshift Mutation; Genes, Bacterial; Microsomes, Liver; Mutagenesis, Insertional; Mutagenicity Tests; Mutagens; Operon; Plasmids; Pyrenes; Salmonella typhimurium; SOS Response, Genetics; Species Specificity; Suppression, Genetic | 1994 |
Metabolism of benzo(a)pyrene, dimethylbenzanthracene and aflatoxin B1 by camel liver microsomes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Benzo(a)pyrene; Camelus; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Male; Microsomes, Liver; Rats | 1994 |
High susceptibility to aflatoxin B1 and benzo[a]pyrene of BALB3T3 A31-1-1 cells expressing monkey CYP1A1.
Topics: 3T3 Cells; Aflatoxin B1; Animals; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Macaca fascicularis; Mice; Transfection | 1993 |
Effect of age on the ability of rat liver tissues to transform chemical promutagens to mutagens.
Topics: Aflatoxin B1; Aging; Animals; Anthracenes; Benzo(a)pyrene; Biotransformation; In Vitro Techniques; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Rats | 1993 |
Cytogenetic effects of promutagens in genetically engineered V79 Chinese hamster cells expressing cytochromes P450.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Genetic Engineering; Mutagens; Rats; Sister Chromatid Exchange | 1993 |
Evaluation of the generation of genotoxic and cytotoxic metabolites of benzo[a]pyrene, aflatoxin B1, naphthalene and tamoxifen using human liver microsomes and human lymphocytes.
Topics: 1-Propanol; Adult; Aflatoxin B1; Benzo(a)pyrene; Carcinogens; Cell Division; Environmental Pollutants; Epoxy Compounds; Estrogen Antagonists; Humans; Male; Microsomes, Liver; Mutagens; NADP; Naphthalenes; Propanols; Sister Chromatid Exchange; Spermatogenesis; Stilbenes; T-Lymphocytes; Tamoxifen; Trichloroepoxypropane | 1995 |
Cassia senna inhibits mutagenic activities of benzo[a]-pyrene, aflatoxin B1, shamma and methyl methanesulfonate.
Topics: Aflatoxin B1; Benzo(a)pyrene; Biotransformation; Cathartics; Dose-Response Relationship, Drug; Histidine; Methyl Methanesulfonate; Mutagenicity Tests; Mutation; Salmonella typhimurium; Senna Extract | 1995 |
Effect of eugenol on the genotoxicity of established mutagens in the liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Antimutagenic Agents; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; DNA; Electrophoresis, Agar Gel; Eugenol; Glutathione Transferase; Humans; Liver; Liver Neoplasms; Male; Micronucleus Tests; Mutagenicity Tests; Mutagens; Rats; Rats, Wistar; Salmonella typhimurium; Tumor Cells, Cultured | 1996 |
Effect of dietary casein levels on activation of promutagens in the spiral Salmonella mutagenicity assay. I. Studies with noninduced rat liver S9.
Topics: Aflatoxin B1; Animals; Anthracenes; Benzo(a)pyrene; Biotransformation; Body Weight; Caseins; Dietary Proteins; Enzymes; Liver; Male; Mutagenicity Tests; Mutagens; Organ Size; Rats; Rats, Inbred F344; Salmonella | 1996 |
Effect of dietary casein levels on activation of promutagens in the spiral Salmonella mutagenicity assay. II. Studies with induced rat liver S9.
Topics: Aflatoxin B1; Animals; Anthracenes; Benzo(a)pyrene; Biotransformation; Body Weight; Caseins; Dietary Proteins; Enzymes; Liver; Male; Mutagenicity Tests; Mutagens; Organ Size; Rats; Rats, Inbred F344; Salmonella | 1996 |
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1996 |
Commentary on "hydroxypropyl cyclodextrins: potential synergism with carcinogens".
Topics: Aflatoxin B1; Benzo(a)pyrene; Carcinogens; Cyclodextrins; Drug Carriers; Drug Synergism; Naphthalenes | 1996 |
Comparative assessment of DNA adduct formation, Salmonella mutagenicity, and chromosome aberration assays as short-term tests for DNA damage.
Topics: Aflatoxin B1; Analysis of Variance; Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Chromosome Aberrations; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Male; Mice; Mutagenesis; Mutagenicity Tests; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Spleen | 1996 |
Hydroxypropyl cyclodextrins: potential synergism with carcinogens.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Aflatoxin B1; Benzo(a)pyrene; beta-Cyclodextrins; Bile; Carcinogens; Chemical Phenomena; Chemistry, Physical; Cyclodextrins; Drug Synergism; Kinetics; Lipid Metabolism; Lipids; Mathematical Computing; Naphthalenes; Solubility; Water | 1996 |
Antimutagenic effect of methanolic extracts from peanut hulls.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxin B1; Animals; Antimutagenic Agents; Arachis; Benzo(a)pyrene; Carbolines; Imidazoles; Male; Methanol; Mutagenicity Tests; Mutagens; Plant Extracts; Quinolines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium | 1996 |
Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens.
Topics: Aflatoxin B1; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Cells, Cultured; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Microsomes; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; Oxazines; Recombinant Proteins; Steroid Hydroxylases; Substrate Specificity; Transfection | 1997 |
Dietary restriction modulated carcinogen-DNA adduct formation and the carcinogen-induced DNA strand breaks.
Topics: Aflatoxin B1; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Chrysenes; DNA Adducts; DNA Damage; Food Deprivation; Kidney; Liver; Male; Mice; Microsomes, Liver; Mutagens; Nitroreductases; Rats | 1997 |
Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxin B1; Animals; Anthracenes; Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Escherichia coli; Gene Expression Regulation, Bacterial; Humans; Mutagenicity Tests; Quinolines; Rats; Recombinant Fusion Proteins | 1998 |
Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monooxygenases and glutathione S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats.
Topics: Aflatoxin B1; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; China; Cytochrome P-450 Enzyme System; Enzyme Induction; Fruit; Glutathione Transferase; Liver; Male; Microsomes, Liver; Ocimum basilicum; Rats; Rats, Wistar; Thailand; Toxicity Tests; Vegetables | 1998 |
Effects of aflatoxin B1 on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo(a)pyrene treatment in chickens.
Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens; Chickens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Induction; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Steroid Hydroxylases | 1999 |
Inhibitory effect of propolis and bee venom on the mutagenicity of some direct- and indirect-acting mutagens.
Topics: Aflatoxin B1; Antimutagenic Agents; Bee Venoms; Benzo(a)pyrene; Brazil; Daunorubicin; Mutagenicity Tests; Mutagens; Phenylenediamines; Propolis; Salmonella typhimurium | 1999 |
In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis.
Topics: Aflatoxin B1; Antimutagenic Agents; Benzo(a)pyrene; Carcinogens; Cassia; Euphorbiaceae; Microsomes, Liver; Mutagenicity Tests; Mutagens; Plant Extracts; Plants, Medicinal; Salmonella typhimurium | 2000 |
Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450.
Topics: Aflatoxin B1; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Beverages; Carcinogens; Catechin; Cell Membrane; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Kinetics; Mixed Function Oxygenases; Mutagenesis; NADPH-Ferrihemoprotein Reductase; Protein Binding; Salmonella typhimurium | 2001 |
Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities.
Topics: Aflatoxin B1; Animals; Benzo(a)pyrene; Diet; Drug Interactions; Flavanones; Flavonoids; Hydroxylation; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mutagenicity Tests; NADPH-Ferrihemoprotein Reductase; Protective Agents | 2001 |
Anti-mutagenic activity of Phyllanthus amarus Schum & Thonn in vitro as well as in vivo.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Antimutagenic Agents; Benzo(a)pyrene; Biotransformation; Drug Evaluation, Preclinical; In Vitro Techniques; Male; Methanol; Methylnitronitrosoguanidine; Phenylenediamines; Phyllanthus; Plant Extracts; Plant Leaves; Plant Stems; Rats; Rats, Wistar; Salmonella typhimurium; Sodium Azide; Solvents; Urine | 2002 |
[Study of mutagenesis of two procarcinogens in human amnion cells using a shuttle vector pWB1].
Topics: Aflatoxin B1; Amnion; Benzo(a)pyrene; Genes, Suppressor; Genetic Vectors; Humans; Mutagenesis; Mutagens; Plasmids; RNA, Transfer | 1999 |
Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.
Topics: Aflatoxin B1; Anthraquinones; Antimutagenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carmine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1B1; Escherichia coli; Humans; Mutagens; Quinoxalines; Recombinant Proteins; Salmonella typhimurium | 2002 |
Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B(1).
Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens; Cats; Cyclophosphamide; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Female; Immunoblotting; Liver; Microsomes, Liver; Mixed Function Oxygenases; Mutagens; Nitrophenols; Protein Isoforms; Rats; Rats, Sprague-Dawley; Reticulocytes; Taenia; Time Factors | 2003 |
Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium.
Topics: Aflatoxin B1; Animals; Anti-Bacterial Agents; Antimutagenic Agents; Asteraceae; Benzo(a)pyrene; Chlorophyll; Chromatography, Thin Layer; Daunorubicin; DNA Damage; Dose-Response Relationship, Drug; Flowers; Mutagenicity Tests; Mutagens; Mutation; Plant Extracts; Rats; Salmonella typhimurium; Triterpenes | 2006 |
Effects of chemical carcinogens and physicochemical factors on the UV spectrophotometric determination of DNA.
Topics: Aflatoxin B1; Base Composition; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chloroform; DNA; Ethanol; Hydrogen-Ion Concentration; Nucleosides; Nucleotides; Pentanols; Phenol; Proteins; RNA; Spectrophotometry, Ultraviolet; Temperature | 2005 |
Development of human cell models for assessing the carcinogenic potential of chemicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Cytochrome P-450 CYP1A1; Genes, myc; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Nickel | 2008 |
Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2).
Topics: Aflatoxin B1; Benzo(a)pyrene; Bleomycin; Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell Line, Tumor; DNA; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Endonucleases; Escherichia coli Proteins; Humans; Intracellular Space; Liver Neoplasms; Micronuclei, Chromosome-Defective; Mutagens; Reactive Oxygen Species; Silybin; Silymarin | 2010 |
Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo.
Topics: Aflatoxin B1; Animal Testing Alternatives; Animals; Benzo(a)pyrene; Biotransformation; Caenorhabditis elegans; Cytochrome P-450 Enzyme System; DNA; DNA Damage; DNA Repair; Mutagens; Phylogeny; Species Specificity | 2010 |
Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.
Topics: Acetaldehyde; Aflatoxin B1; Benzo(a)pyrene; Carcinogens; Fibroblasts; Humans; Mutagens; Mutation; Neoplasms; Tumor Suppressor Protein p53 | 2012 |
A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds.
Topics: Aflatoxin B1; Benzo(a)pyrene; Biotransformation; Caco-2 Cells; Cell Line; Coculture Techniques; Comet Assay; DNA Damage; Humans; Methyl Methanesulfonate; Micronucleus Tests; Mutagens | 2012 |
Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes.
Topics: Adult; Aflatoxin B1; Animal Use Alternatives; Benzo(a)pyrene; Biliary Tract; Biotransformation; Cell Line, Tumor; Cells, Cultured; Child; Epithelium; Female; Gene Expression Profiling; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Infant; Male; Mutagens; Principal Component Analysis; Reproducibility of Results; Toxicogenetics | 2013 |
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices.
Topics: Acetaminophen; Aflatoxin B1; Benzo(a)pyrene; Cell Survival; Comet Assay; Cytochrome P-450 Enzyme System; DNA Damage; Fluorenes; Gene Expression; Glutathione Transferase; Humans; L-Lactate Dehydrogenase; Liver; NAD(P)H Dehydrogenase (Quinone); Xenobiotics | 2014 |
Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.
Topics: Activation, Metabolic; Aflatoxin B1; Animals; Apoptosis; Benzo(a)pyrene; Cell Line; Cell Survival; Cisplatin; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Profiling; Genetic Markers; Humans; Micronucleus Tests; Mutagens; Phenobarbital; Rats; Reproducibility of Results; Toxicogenetics | 2015 |
Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells.
Topics: Aflatoxin B1; Benzo(a)pyrene; Cell Line, Tumor; Comet Assay; DNA; DNA Damage; Endosulfan; Hep G2 Cells; Histones; Humans; Micronucleus Tests; Mutagenicity Tests; Mutagens; Phosphorylation; Pyrazoles | 2016 |
MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells.
Topics: Aflatoxin B1; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Dose-Response Relationship, Drug; Hepatocyte Nuclear Factor 4; Humans; Liver Neoplasms; MicroRNAs | 2016 |
Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics.
Topics: Aflatoxin B1; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Comet Assay; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P-450 CYP1A1; DNA Damage; DNA Repair; DNA-Binding Proteins; Gene Expression Profiling; Hep G2 Cells; Hepatocytes; Histones; Humans; Phosphorylation; Proteomics; Receptors, Aryl Hydrocarbon; RNA Interference; Time Factors; Transcription Factors; Transcriptome; Transfection; Tumor Suppressor Protein p53 | 2017 |
Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?
Topics: Aflatoxin B1; Benzo(a)pyrene; Cell Line, Tumor; Dimethylnitrosamine; Humans; Hydrogen Peroxide; Imidazoles; Inactivation, Metabolic; Liver; Mutagenicity Tests; Mutagens; Quinolines; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2018 |
Adipose tissue stem cell-derived hepatic progenies as an in vitro model for genotoxicity testing.
Topics: Adipose Tissue; Aflatoxin B1; Benzo(a)pyrene; Cell Differentiation; Cell Line; Comet Assay; Enzymes; Female; Hep G2 Cells; Humans; Imidazoles; Liver; Mesenchymal Stem Cells; Mutagenicity Tests | 2018 |
Effect of aflatoxin B
Topics: Aflatoxin B1; Benzo(a)pyrene; Cell Line; DNA Adducts; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Hepatocytes; Humans; Methapyrilene; Nucleic Acid Amplification Techniques; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Transcription, Genetic; Transcriptome | 2018 |
An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests.
Topics: Aflatoxin B1; Benzo(a)pyrene; Cells, Cultured; Comet Assay; Cyclophosphamide; Cytochrome P-450 Enzyme System; Diethylnitrosamine; DNA Damage; Fluorenes; Hepatocytes; Humans; Karyotype; Methyl Methanesulfonate; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Mutagens | 2019 |
The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling.
Topics: Activation, Metabolic; Aflatoxin B1; Benchmarking; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatocytes; High-Throughput Nucleotide Sequencing; Humans; Transcriptome | 2019 |
Micronuclei Formation by Promutagens in Metabolism-Incompetent V79 Cells Interacting With Activation-Proficient Cells in Various Experimental Settings.
Topics: Aflatoxin B1; Animals; Arylsulfotransferase; Benzo(a)pyrene; Cell Line; Cricetinae; Cytochrome P-450 Enzyme System; Humans; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagens; Pyrenes | 2020 |
Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line.
Topics: Aflatoxin B1; Benchmarking; Benzo(a)pyrene; Cell Line; Cyclosporine; Lipids; Metabolomics; Rotenone | 2023 |
Cuproptosis-related gene identification and immune infiltration analysis in systemic lupus erythematosus.
Topics: Aflatoxin B1; Apoptosis; Autoimmune Diseases; Benzo(a)pyrene; Copper; Humans; Lupus Erythematosus, Systemic; MicroRNAs; Molecular Docking Simulation | 2023 |