aflatoxin b1-2,3-oxide has been researched along with aflatoxin b1 in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (12.28) | 18.7374 |
| 1990's | 31 (54.39) | 18.2507 |
| 2000's | 13 (22.81) | 29.6817 |
| 2010's | 6 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, EA; Waters, R | 1 |
| Buetler, TM; Eaton, DL; Slone, D | 1 |
| Hayes, JD; Judah, DJ; Neal, GE; Nguyen, T | 1 |
| Gopalan, P; Jensen, DE; Lotlikar, PD | 1 |
| Hayes, JD; Judah, DJ; McLellan, LI; Neal, GE | 1 |
| Lin, JK; Shiah, HS; Wang, CJ | 1 |
| Hayes, JD; Judah, DJ; Kerr, LA; McLellan, LI; Neal, GE; Peacock, SD | 1 |
| Daniels, JM; Liu, L; Massey, TE; Stewart, RK | 1 |
| Eaton, DL; Ramsdell, HS | 1 |
| Humayun, MZ; Sahasrabudhe, S; Sambamurti, K | 1 |
| Conley, MP; Humayun, MZ; Jacobsen, JS; Refolo, LM; Sambamurti, K | 1 |
| Miller, EC; Miller, JA; Swenson, DH | 1 |
| Manson, MM; Moss, EJ; Neal, GE | 1 |
| Buhler, DR; Williams, DE | 1 |
| Clearfield, MS; Lotlikar, PD; Raj, HG | 1 |
| Degen, GH; Neumann, HG | 1 |
| Bender, W; Hutchcroft, A; Yu, FL | 1 |
| Chen, W; Chou, MW; Chung, KT; Hart, RW; Nichols, J; Zhou, Y | 1 |
| Chemin, I; Chisari, FV; Kirby, GM; Lang, MA; Montesano, R; Wild, CP | 1 |
| Gopalan-Kriczky, P; Jensen, DE; Lotlikar, D | 1 |
| Hayes, JD; Judah, DJ; Neal, GE; Nguyen, T; Petersson, DG | 1 |
| Berlad, LG; Eaton, DL; Gallagher, EP; Ramsdell, HS; Rettie, AE; Slone, DH; Stapleton, PL | 1 |
| Ross, MK; Said, B; Salib, T; Shank, RC | 1 |
| Bammler, TK; Buetler, TM; Eaton, DL; Hayes, JD | 1 |
| Ali, SL; Conlan, AA; Donnelly, PJ; Massey, TE; Petsikas, D; Reid, KR; Stewart, RK | 1 |
| Cahill, JM; Dipple, A; Lipinski, LJ; Yu, FL | 1 |
| Guengerich, FP; Hayes, JD; Johnson, WW; Ketterer, B; Mannervik, B; Sherratt, PJ; Ueng, YF; Widersten, M | 1 |
| Guengerich, FP; Johnson, WW | 2 |
| Guengerich, FP; Johnson, WW; Shimada, T; Ueng, YF; Yamazaki, H | 1 |
| Jones, WR; Stone, MP | 1 |
| Chen, JX; Tang, MS; West, M; Zheng, Y | 1 |
| Bammler, TK; Eaton, DL; McHugh, TE; Van Ness, KP | 1 |
| Mathison, BH; Ross, MK; Said, B; Shank, RC | 1 |
| Hayes, JD; Judah, DJ; Lian, LY; McDonagh, PD; Neal, GE; Roberts, GC; Wolf, CR | 1 |
| Alaoui-Jamali, MA; Groisman, IJ; Groopman, JD; Henkler, F; Koshy, R | 1 |
| Cahill, J; Denissenko, MF; Gerber, N; Koudriakova, TB; Pfeifer, GP | 1 |
| Hamade, AK; Matsumoto, DC; Ross, MK; Said, B; Shank, RC | 1 |
| Ross, MK; Said, B; Shank, RC | 1 |
| Buckner, R; Coulombe, RA; Kelly, J; Klein, PJ | 1 |
| Alaoui-Jamali, MA; Batist, G; Benlimame, N; Galipeau, J; Jaitovitch-Groisman, I; Sohn, S | 1 |
| Bammler, TK; Eaton, DL; Guo, Y; Kelly, EJ; Wang, C | 1 |
| Chuturgoon, AA; Dutton, MF; Palanee, T | 1 |
| Bammler, TK; Eaton, DL; Kelly, EJ | 1 |
| Arneson, KO; Deng, Z; Guengerich, FP; Harris, TM; Williams, KM | 1 |
| Esaki, H; Kumagai, S | 1 |
| Feng, Z; Hu, W; Tang, MS | 1 |
| Hayes, JD; Itoh, K; Jiang, Q; Jowsey, IR; Yamamoto, M | 1 |
| Brockmöller, J; Hustert, E; Kirk, G; Mendy, M; Pedersen, B; Turner, PC; Whittle, HC; Wild, CP; Wojnowski, L | 1 |
| Bren, U; Brown, KL; Guengerich, FP; Stone, MP | 1 |
| Netz, PA; Ricci, CG | 1 |
| Boermans, HJ; Cepeda, SM; Diaz, GJ; Murcia, HW | 1 |
| Bunderson, BR; Coulombe, RA; Croasdell, A; Kim, JE | 1 |
| Chen, Q; Chen, R; Deng, Y; Jiang, J; Li, K; Mu, P; Wang, L; Wen, J; Wu, J; Xu, W; Zhang, C | 1 |
| Chawanthayatham, S; Croy, RG; Egner, PA; Essigmann, JM; Fedeles, BI; Groopman, JD; Satayavivad, J; Slocum, SL; Sriwattanapong, K | 1 |
| Choudhary, D; Jiang, D; Kadimisetty, K; Malla, S; Rusling, JF | 1 |
| Rushing, BR; Selim, MI | 1 |
4 review(s) available for aflatoxin b1-2,3-oxide and aflatoxin b1
| Article | Year |
|---|---|
Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Drug Resistance; Glutathione Transferase; Humans; Liver; Molecular Sequence Data; Species Specificity | 1991 |
Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication.
Topics: Aflatoxin B1; Animals; Carcinogens; DNA; Epoxide Hydrolases; Epoxy Compounds; Glutathione; Humans; Hydrolysis; Inactivation, Metabolic; Kinetics | 1999 |
Interindividual differences in response to chemoprotection against aflatoxin-induced hepatocarcinogenesis: implications for human biotransformation enzyme polymorphisms.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Glutathione Transferase; Humans; Inactivation, Metabolic; Liver Neoplasms; Polymorphism, Genetic; Species Specificity | 2001 |
Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods.
Topics: Aflatoxin B1; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Decontamination; DNA Adducts; Food Contamination; Gamma Rays; Growth Disorders; Humans; Immunologic Factors; Liver Neoplasms; Malnutrition; Occupational Exposure | 2019 |
53 other study(ies) available for aflatoxin b1-2,3-oxide and aflatoxin b1
| Article | Year |
|---|---|
Sensitivity and single-strand DNA break repair in Chinese hamster mutants exposed to the carcinogen aflatoxin B1 epoxide and its dichloride model.
Topics: Aflatoxin B1; Animals; Carcinogenicity Tests; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Damage; DNA Repair; DNA, Single-Stranded; Mutagenicity Tests; Mutation | 1992 |
Comparison of the aflatoxin B1-8,9-epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat.
Topics: Aflatoxin B1; Animals; Base Sequence; Cloning, Molecular; Escherichia coli; Genetic Vectors; Glutathione Transferase; Isoenzymes; Kinetics; Liver; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Plasmids; Polymerase Chain Reaction; Rats; Recombinant Proteins; Restriction Mapping | 1992 |
Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Catalysis; Chromatography, High Pressure Liquid; Cloning, Molecular; DNA; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Glutathione Transferase; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Plasmids; Restriction Mapping | 1992 |
Glutathione conjugation of microsome-mediated and synthetic aflatoxin B1-8,9-oxide by purified glutathione S-transferases from rats.
Topics: Aflatoxin B1; Animals; Cytosol; Epoxy Compounds; Glutathione; Glutathione Transferase; Isoenzymes; Liver; Male; Microsomes, Liver; Rats; Rats, Inbred F344 | 1992 |
Modulatory effect of crocetin on aflatoxin B1 cytotoxicity and DNA adduct formation in C3H10T1/2 fibroblast cell.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carotenoids; Cell Survival; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Drug Antagonism; Fibroblasts; Glutathione; Glutathione Peroxidase; Glutathione Transferase; In Vitro Techniques; Male; Mice; Mice, Inbred C3H; Rats; Rats, Inbred Strains; Vitamin A | 1991 |
Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Drug Resistance; Enzyme Induction; Ethoxyquin; Glutathione Transferase; Immunohistochemistry; Isoenzymes; Liver; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Peptide Mapping; Rats; Rats, Inbred F344; Substrate Specificity | 1991 |
Biotransformation of aflatoxin B1 in rabbit lung and liver microsomes.
Topics: Aflatoxin B1; Aflatoxin M1; Aflatoxins; Animals; Biotransformation; Carcinogens; DNA; Kinetics; Lung; Male; Microsomes; Microsomes, Liver; NADP; Pyridines; Rabbits | 1990 |
Mouse liver glutathione S-transferase isoenzyme activity toward aflatoxin B1-8,9-epoxide and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Chromatography, Affinity; Cytosol; Glutathione Transferase; Liver; Macromolecular Substances; Male; Mice; Substrate Specificity | 1990 |
Mutagenesis by aflatoxin in M13 DNA: base-substitution mechanisms and the origin of strand bias.
Topics: Aflatoxin B1; Aflatoxins; Amino Acid Sequence; Bacteriophages; Base Composition; Base Sequence; DNA Mutational Analysis; DNA Replication; DNA, Viral; Escherichia coli; Molecular Sequence Data; Mutagens; Nucleic Acid Heteroduplexes | 1989 |
DNA replication-blocking properties of adducts formed by aflatoxin B1-2,3-dichloride and aflatoxin B1-2,3-oxide.
Topics: Aflatoxin B1; Aflatoxins; Base Composition; DNA; DNA Damage; DNA Replication; DNA, Bacterial; DNA, Single-Stranded; DNA, Viral; Guanine; Magnesium; Manganese; Nucleic Acid Conformation; Repetitive Sequences, Nucleic Acid | 1987 |
Aflatoxin B1-2,3-oxide: evidence for its formation in rat liver in vivo and by human liver microsomes in vitro.
Topics: Aflatoxin B1; Aflatoxins; Animals; Binding Sites; Carcinogens; Chromatography, Thin Layer; DNA; Ethers, Cyclic; Female; Humans; Hydrolysis; In Vitro Techniques; Liver; Male; Methyl Ethers; Methylation; Microsomes, Liver; Middle Aged; Rats; RNA, Ribosomal; Tritium | 1974 |
Effect of manipulation of gamma-glutamyl transpeptidase levels on biliary excretion of aflatoxin B1 conjugates.
Topics: Aflatoxin B1; Aflatoxins; Animals; Bile; gamma-Glutamyltransferase; Glutathione; Histocytochemistry; Liver; Rats; Rats, Inbred F344 | 1984 |
Purified form of cytochrome P-450 from rainbow trout with high activity toward conversion of aflatoxin B1 to aflatoxin B1-2,3-epoxide.
Topics: Aflatoxin B1; Aflatoxins; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Microsomes, Liver; Rats; Trout | 1983 |
Comparative kinetic studies on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with rat and hamster livers in vitro.
Topics: Aflatoxin B1; Aflatoxins; Animals; Biotransformation; Cricetinae; DNA; Glutathione; In Vitro Techniques; Liver; Male; Mesocricetus; Rats; Rats, Inbred Strains | 1984 |
Differences in aflatoxin B1-susceptibility of rat and mouse are correlated with the capability in vitro to inactivate aflatoxin B1-epoxide.
Topics: Aflatoxin B1; Aflatoxins; Animals; Chromatography, High Pressure Liquid; Female; Inactivation, Metabolic; Liver; Male; Mice; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity | 1981 |
Studies on the binding and transcriptional properties of aflatoxin B1-8,9-epoxide.
Topics: Aflatoxin B1; DNA; Dose-Response Relationship, Drug; Poly C; Poly G; RNA; Transcription, Genetic | 1994 |
Effect of dietary restriction on glutathione S-transferase activity specific toward aflatoxin B1-8,9-epoxide.
Topics: Aflatoxin B1; Animals; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytosol; DNA; DNA Adducts; Dose-Response Relationship, Drug; Food Deprivation; Glutathione Transferase; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred F344; Substrate Specificity | 1995 |
Induction of specific cytochrome P450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice.
Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hepatitis B virus; Liver Neoplasms, Experimental; Mice; Mice, Transgenic; Mixed Function Oxygenases; Viral Envelope Proteins | 1994 |
Conjugation of microsome generated and synthetic aflatoxin B1-8,9 epoxide and styrene oxide to glutathione by purified glutathione S-transferases from hamster and mouse livers.
Topics: Aflatoxin B1; Animals; Cricetinae; Cytosol; Epoxy Compounds; Glutathione; Glutathione Transferase; Liver; Male; Mesocricetus; Mice; Mice, Inbred BALB C; Microsomes, Liver; Rats; Rats, Inbred F344; Sensitivity and Specificity; Species Specificity | 1994 |
Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Cloning, Molecular; DNA, Complementary; Drug Resistance; Enzyme Induction; Escherichia coli; Female; Glutathione Transferase; Humans; Inactivation, Metabolic; Liver; Male; Molecular Sequence Data; Peptide Fragments; Rats; Rats, Inbred F344; Sequence Homology, Amino Acid | 1994 |
Human variability in hepatic glutathione S-transferase-mediated conjugation of aflatoxin B1-epoxide and other substrates.
Topics: Adolescent; Adult; Aflatoxin B1; Animals; Cricetinae; Cytosol; Female; Glutathione Transferase; Humans; Kinetics; Liver; Male; Mice; Middle Aged; Rats; Species Specificity; Substrate Specificity | 1995 |
Modulation of DNA adduct formation by successive exposures of DNA to small and bulky chemical carcinogens.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetoxyacetylaminofluorene; Aflatoxin B1; Bacteriophage M13; Base Sequence; Carcinogens; DNA; DNA Adducts; DNA Primers; Methylnitrosourea; Molecular Sequence Data | 1995 |
Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.
Topics: Aflatoxin B1; Aflatoxins; Animals; Anticarcinogenic Agents; Base Sequence; Biotransformation; Carcinogens; Clofibric Acid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Glutathione Transferase; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases; Pregnenolone Carbonitrile; Pyrazines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Species Specificity; Steroid Hydroxylases; Thiones; Thiophenes | 1996 |
Biotransformation of aflatoxin B1 in human lung.
Topics: Aflatoxin B1; Aged; Animals; Biotransformation; Carcinogens; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytosol; Female; Glutathione Transferase; Humans; Inactivation, Metabolic; Lipoxygenase; Lung; Macrophages, Alveolar; Male; Microsomes; Middle Aged; Prostaglandin-Endoperoxide Synthases; Pulmonary Alveoli; Rabbits; Subcellular Fractions | 1996 |
Effect of aflatoxin B1-8,9-epoxide-DNA adducts on transcription of a supF gene fragment.
Topics: Aflatoxin B1; Base Sequence; Dimethyl Sulfoxide; DNA Adducts; DNA-Directed RNA Polymerases; Genes, Suppressor; Genetic Vectors; Molecular Sequence Data; RNA; RNA, Transfer; Transcription, Genetic; Viral Proteins | 1996 |
Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters.
Topics: Aflatoxin B1; Animals; Glutathione; Glutathione Transferase; Humans; Kinetics; Rats; Recombinant Proteins | 1997 |
Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis.
Topics: Aflatoxin B1; Animals; Cattle; DNA; Hydrolysis; Isomerism; Kinetics; Poly dA-dT; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1997 |
Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.
Topics: Aflatoxin B1; Animals; Epoxide Hydrolases; Humans; Hydrolysis; Kinetics; Liver; Mutagenicity Tests; Rabbits; Rats; SOS Response, Genetics | 1997 |
Site-specific targeting of aflatoxin adduction directed by triple helix formation in the major groove of oligodeoxyribonucleotides.
Topics: Aflatoxin B1; Base Sequence; Binding Sites; DNA Adducts; Hydrogen-Ion Concentration; Mutagens; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Repetitive Sequences, Nucleic Acid | 1998 |
Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.
Topics: Acetoxyacetylaminofluorene; Aflatoxin B1; Binding Sites; Carcinogens; CpG Islands; Cytosine; DNA Methylation; Genes, p53; Humans; Mutation; Neoplasms | 1998 |
Identification of amino acid residues essential for high aflatoxin B1-8,9-epoxide conjugation activity in alpha class glutathione S-transferases through site-directed mutagenesis.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Binding Sites; Dinitrochlorobenzene; Epitopes; Escherichia coli; Ethacrynic Acid; Glutathione Transferase; Mice; Microsomes, Liver; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Sequence Homology, Amino Acid | 1998 |
5-Methylcytosine in CpG sites and the reactivity of nearest neighboring guanines toward the carcinogen aflatoxin B1-8,9-epoxide.
Topics: 5-Methylcytosine; Aflatoxin B1; Carcinogens; Cytosine; Gene Expression Regulation, Neoplastic; Genes, p53; Guanine; Humans; Oligonucleotides | 1999 |
Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Catalysis; Glutathione Transferase; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis; Rats; Sequence Homology, Amino Acid; Substrate Specificity | 1999 |
Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells.
Topics: Aflatoxin B1; Chloramphenicol O-Acetyltransferase; Cytomegalovirus; DNA Damage; DNA Repair; Down-Regulation; Humans; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays; Viral Regulatory and Accessory Proteins | 1999 |
Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems.
Topics: Aflatoxin B1; Animals; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA Adducts; DNA Damage; Genes, p53; Humans; Intestinal Mucosa; Liver; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley | 1999 |
DNA-damaging effects of genotoxins in mixture: nonadditive effects of aflatoxin B1 and N-acetylaminofluorene on their mutagenicity in Salmonella typhimurium.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Aflatoxin B1; Alleles; DNA Damage; Frameshift Mutation; Mutagenicity Tests; Mutagens; Salmonella typhimurium | 1999 |
DNA-damaging effects of genotoxins in mixture: modulation of covalent binding to DNA.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Binding, Competitive; Cattle; DNA; DNA Adducts; DNA Damage; Guanine; Mutagens; Sulfuric Acid Esters | 2000 |
Biochemical basis for the extreme sensitivity of turkeys to aflatoxin B(1).
Topics: Aflatoxin B1; Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Inactivation, Metabolic; Male; Microsomes, Liver; Mixed Function Oxygenases; Species Specificity; Turkeys | 2000 |
Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Apoptosis; Carcinogens; Cell Cycle; Cell Line; Codon; Disease Susceptibility; DNA Mutational Analysis; Genes, p53; Genetic Vectors; Hepatitis B virus; Humans; Liver; Mutagenesis, Site-Directed; Mutagens; Mutation; Polymerase Chain Reaction; Trans-Activators; Transduction, Genetic; Viral Regulatory and Accessory Proteins | 2000 |
Mu-class GSTs are responsible for aflatoxin B(1)-8, 9-epoxide-conjugating activity in the nonhuman primate macaca fascicularis liver.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Blotting, Western; Carcinogens; Chondroitin Sulfates; Chromatography, Affinity; Cloning, Molecular; Disaccharides; DNA, Complementary; Liver; Macaca fascicularis; Male; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2000 |
Cytotoxicity of aflatoxin B1 and its chemically synthesised epoxide derivative on the A549 human epithelioid lung cell line.
Topics: Aflatoxin B1; Carcinogens; Epithelioid Cells; Formazans; Humans; Lung; Tetrazolium Salts; Tumor Cells, Cultured | 2001 |
Reaction of aflatoxin B(1) oxidation products with lysine.
Topics: Aflatoxin B1; Aldehydes; Animals; Binding Sites; Binding, Competitive; Buffers; Cattle; Chromatography, High Pressure Liquid; Glutathione; Hydrogen-Ion Concentration; Kinetics; Lysine; Oxidation-Reduction; Serum Albumin; Serum Albumin, Bovine; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet | 2002 |
Glutathione-S-transferase activity toward aflatoxin epoxide in livers of mastomys and other rodents.
Topics: Aflatoxin B1; Animals; Carcinogens; Cricetinae; Cytosol; DNA; Glutathione Transferase; Liver; Mesocricetus; Mice; Mice, Inbred ICR; Microsomes, Liver; Muridae; Rats; Rats, Inbred F344; Species Specificity | 2002 |
Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Bronchi; Carcinogens; Cells, Cultured; Codon; CpG Islands; Cytosine; DNA; DNA Adducts; DNA Damage; DNA Methylation; Endodeoxyribonucleases; Epithelial Cells; Escherichia coli Proteins; Exons; Fluorenes; Genes, ras; Humans; Mutation | 2003 |
Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element.
Topics: Aflatoxin B1; Animals; Antioxidants; Base Sequence; Chromosome Mapping; DNA; DNA-Binding Proteins; Exons; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Isothiocyanates; Mice; Molecular Sequence Data; NF-E2-Related Factor 2; Protein Subunits; Regulatory Sequences, Nucleic Acid; Response Elements; Sequence Homology, Nucleic Acid; Sulfoxides; Thiocyanates; Trans-Activators; Tumor Cells, Cultured | 2003 |
Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.
Topics: Adolescent; Adult; Aflatoxin B1; Aflatoxins; Aged; Albumins; Base Sequence; Carcinoma, Hepatocellular; Child; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; Female; Gambia; Gene Expression; Gene Frequency; Genetic Variation; Haplotypes; Humans; Liver Neoplasms; Male; Middle Aged; Mutagens; Polymorphism, Genetic; Risk Factors | 2004 |
Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and efficiency of DNA catalysis.
Topics: Aflatoxin B1; Catalysis; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Stereoisomerism; Tandem Mass Spectrometry; Thermodynamics | 2009 |
Docking studies on DNA-ligand interactions: building and application of a protocol to identify the binding mode.
Topics: Acridines; Aflatoxin B1; Binding Sites; Computer Simulation; Crystallography, X-Ray; DNA; Ellipticines; Ligands; Models, Molecular; Netropsin; Nucleic Acid Conformation | 2009 |
The role of selected cytochrome P450 enzymes on the bioactivation of aflatoxin B1 by duck liver microsomes.
Topics: Aflatoxin B1; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Ducks; Female; Fluorescence; Male; Microsomes, Liver | 2010 |
Functional characterization of alpha-class glutathione s-transferases from the Turkey (meleagris gallopavo).
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Cloning, Molecular; Cytosol; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutathione Transferase; Humans; Isoenzymes; Liver; Male; Mice; Molecular Sequence Data; Protein Structure, Secondary; Protein Subunits; Rats; Sequence Alignment; Species Specificity; Substrate Specificity; Turkeys | 2011 |
Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B₁.
Topics: Activation, Metabolic; Aflatoxin B1; Allosteric Regulation; Animals; Binding Sites; Cloning, Molecular; Cytochrome P-450 CYP3A; Isoenzymes; Liver; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Conformation; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Sus scrofa | 2016 |
Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver.
Topics: Activation, Metabolic; Aflatoxin B1; Animals; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; DNA Adducts; DNA Damage; Female; Gestational Age; Glutathione Transferase; Guanine; Hepatocytes; Isoenzymes; Liver; Maternal Exposure; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Pregnancy | 2017 |
Pathways of Metabolite-Related Damage to a Synthetic p53 Gene Exon 7 Oligonucleotide Using Magnetic Enzyme Bioreactor Beads and LC-MS/MS Sequencing.
Topics: Aflatoxin B1; Bioreactors; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Exons; Humans; Magnetic Fields; Mass Spectrometry; Oligonucleotides; Sequence Analysis, DNA; Tumor Suppressor Protein p53 | 2018 |