Compounds > afdx 384
Page last updated: 2024-09-03

afdx 384 and n-methylscopolamine

afdx 384 has been researched along with n-methylscopolamine in 6 studies

Compound Research Comparison

Studies
(afdx 384)		Trials
(afdx 384)		Recent Studies (post-2010)
(afdx 384)		Studies
(n-methylscopolamine)		Trials
(n-methylscopolamine)		Recent Studies (post-2010) (n-methylscopolamine)
78061,0261252

Protein Interaction Comparison

ProteinTaxonomyafdx 384 (IC50)n-methylscopolamine (IC50)
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.335
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.0023
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.0023
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.0018
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.0011

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wells, JW; Wreggett, KA1
Adem, A; Hellman, U; Jolkkonen, M; Karlsson, E; Kumlin, E; Satyapan, N; Wernstedt, C1
Adem, A; Cowburn, RF; Lannfelt, L; Venizelos, N; Vestling, M; Winblad, B1
Berlan, M; Galitzky, J; Merial, C; Montastruc, JL; Pelat, M; Senard, JM; Verwaerde, P1
Dauphin, F; Deagostino, A; Desbène, PL; Ducandas, C; Lasne, MC; Martin, J; Morin, C; Perrio, C1
Hirata, K; Horita, S; Iwata, S; Kinoshita, M; Kobayashi, T; Kobilka, BK; Lee, S; Maeda, S; Murata, T; Suno, R; Tawaramoto, MS; Tsujimoto, H; Vaidehi, N; Yamamoto, M; Yamashita, K; Yasuda, S1

Other Studies

6 other study(ies) available for afdx 384 and n-methylscopolamine

ArticleYear
Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors.
    The Journal of biological chemistry, 1995, Sep-22, Volume: 270, Issue:38

    Topics: Allosteric Regulation; Animals; GTP-Binding Proteins; Guanylyl Imidodiphosphate; In Vitro Techniques; Molecular Weight; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Sarcolemma; Scopolamine Derivatives; Swine

1995
Protein toxins that bind to muscarinic acetylcholine receptors.
    Annals of the New York Academy of Sciences, 1994, Mar-09, Volume: 710

    Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Consensus Sequence; Elapid Venoms; Elapidae; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Protein Binding; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Sequence Homology, Amino Acid; Swine; Synaptosomes

1994
Characterization of muscarinic acetylcholine receptors in cultured adult skin fibroblasts: effects of the Swedish Alzheimer's disease APP 670/671 mutation on binding levels.
    Journal of neural transmission. Parkinson's disease and dementia section, 1995, Volume: 10, Issue:1

    Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Cells, Cultured; Fibroblasts; Humans; Mutation; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Reference Values; Scopolamine Derivatives; Skin; Sweden

1995
Impaired atrial M(2)-cholinoceptor function in obesity-related hypertension.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:5

    Topics: Adenylyl Cyclases; Animals; Blood Pressure; Body Weight; Dogs; Dose-Response Relationship, Drug; Heart Atria; Hypertension; Male; N-Methylscopolamine; Obesity; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic

1999
Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:3

    Topics: Animals; Binding, Competitive; Cyclodextrins; Electrophoresis, Capillary; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Rats; Solvents; Stereoisomerism; Tritium

2000
Structural insights into the subtype-selective antagonist binding to the M
    Nature chemical biology, 2018, Volume: 14, Issue:12

    Topics: Binding Sites; Crystallography, X-Ray; Enzyme Stability; Humans; Molecular Dynamics Simulation; Muscarinic Antagonists; Mutation; N-Methylscopolamine; Pirenzepine; Receptor, Muscarinic M2

2018