Compounds > afdx 384
Page last updated: 2024-09-03

afdx 384 and afdx 116

afdx 384 has been researched along with afdx 116 in 5 studies

Compound Research Comparison

Studies
(afdx 384)		Trials
(afdx 384)		Recent Studies (post-2010)
(afdx 384)		Studies
(afdx 116)		Trials
(afdx 116)		Recent Studies (post-2010) (afdx 116)
7806367124
500367124

Protein Interaction Comparison

ProteinTaxonomyafdx 384 (IC50)afdx 116 (IC50)
Muscarinic acetylcholine receptor M2Homo sapiens (human)1.8
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)2.927
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)3.4558
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)2.927
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)2.927
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)2.5994
Muscarinic acetylcholine receptor M2Mus musculus (house mouse)6.2

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Costa, LG; Fitzgerald, BB1
Gibson, VA; McKinney, M; Miller, JH1
Entzeroth, M; Mayer, N1
Bellanger, C; Boutin, H; Chevalier, C; Dauphin, F; MacKenzie, ET; Mickala, P1
Casida, JE; Honda, H; Tomizawa, M1

Other Studies

5 other study(ies) available for afdx 384 and afdx 116

ArticleYear
Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats.
    Toxicology and applied pharmacology, 1992, Volume: 117, Issue:1

    Topics: Animals; Brain; Disulfoton; Male; Organophosphorus Compounds; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tritium

1992
Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: Animals; Binding Sites; Binding, Competitive; Brain Stem; Cerebral Cortex; CHO Cells; Cloning, Molecular; Corpus Striatum; Cricetinae; Kinetics; Myocardium; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Tritium

1991
Labeling of rat heart muscarinic receptors using the new M2 selective antagonist [3H]AF-DX 384.
    Biochemical pharmacology, 1990, Oct-01, Volume: 40, Issue:7

    Topics: Affinity Labels; Animals; Atropine; Binding, Competitive; Male; Muscarinic Antagonists; Myocardium; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1990
In vivo binding, pharmacokinetics and metabolism of the selective M2 muscarinic antagonists [3H]AF-DX 116 and [3H]AF-DX 384 in the anesthetized rat.
    Nuclear medicine and biology, 1996, Volume: 23, Issue:2

    Topics: Anesthesia; Animals; Brain; Chromatography, Thin Layer; Half-Life; Male; Muscarinic Antagonists; Parasympatholytics; Pirenzepine; Rats; Rats, Sprague-Dawley; Tissue Distribution

1996
Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists.
    Journal of agricultural and food chemistry, 2007, Mar-21, Volume: 55, Issue:6

    Topics: Animals; Brain; Drosophila; Houseflies; Insecta; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tritium

2007