afdx 116 has been researched along with scopolamine hydrobromide in 16 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (scopolamine hydrobromide) | Trials (scopolamine hydrobromide) | Recent Studies (post-2010) (scopolamine hydrobromide) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 7,548 | 563 | 1,401 |
| Protein | Taxonomy | afdx 116 (IC50) | scopolamine hydrobromide (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.003 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.006 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.0006 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0026 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 9 (56.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deaciuc, A; Dwoskin, LP; Huang, X; Siripurapu, KB; Smith, AM; Subramanian, KL; Zhan, CG; Zheng, G | 1 |
| Bian, CF; Qin, W; Yu, AY; Zheng, JL | 1 |
| Frey, KA; Howland, MM | 1 |
| Bhattacharya, SK; Das Gupta, G; Sen, AP; Seth, K; Seth, PK | 1 |
| Gies, JP; Haddad, EB; Landry, Y | 1 |
| Bian, CF; Hong, XM; Yin, XX; Zhou, J | 1 |
| Arrang, JM; Gulat-Marnay, C; Lafitte, A; Schwartz, JC | 1 |
| Sapru, H; Sundaram, K | 1 |
| Bai, D; Sattelle, DB | 1 |
| Abe, K; Mizutani, A; Nakata, A; Saito, H | 1 |
| Bian, CF; Ge, XQ; Qin, W; Yao, B; Zheng, JL | 1 |
| Rivers, RJ | 1 |
| Baghdoyan, HA; Douglas, CL; Lydic, R | 1 |
| Bermúdez-Rattoni, F; Escobar, ML; Espinosa, E; Miranda, MI; Ramírez-Lugo, L | 1 |
| Mamiya, T; Okuda, A; Ukai, M | 1 |
| Chen, HJ; Corcoran, KA; Guedea, AL; Jovasevic, V; Leaderbrand, K; Radulovic, J; Wess, J | 1 |
16 other study(ies) available for afdx 116 and scopolamine hydrobromide
| Article | Year |
|---|---|
Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.
Topics: Animals; CHO Cells; Corpus Striatum; Cricetinae; Cricetulus; Dopamine; Esters; Humans; In Vitro Techniques; Molecular Docking Simulation; Muscarinic Agonists; Oxotremorine; Pyridines; Radioligand Assay; Rats; Receptor, Muscarinic M5; Structure-Activity Relationship | 2013 |
[Muscarinic receptor subtypes in respiratory center and their functions].
Topics: Animals; Atropine; Blood Gas Analysis; Female; Male; Medulla Oblongata; Pilocarpine; Pirenzepine; Pons; Rabbits; Radioligand Assay; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, Muscarinic; Respiration; Respiratory Center; Scopolamine; Tidal Volume | 1992 |
Quantitative autoradiography of muscarinic cholinergic receptor binding in the rat brain: distinction of receptor subtypes in antagonist competition assays.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Male; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine | 1992 |
Central muscarinic receptor subtypes and carrageenin-induced paw oedema in rats.
Topics: Animals; Arecoline; Carbachol; Carrageenan; Cerebellum; Corpus Striatum; Edema; Female; Foot; Gallamine Triethiodide; Inflammation; Male; Oxotremorine; Pirenzepine; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine | 1991 |
Sialic acid residues as catalysts for M2-muscarinic agonist-receptor interactions.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cell Membrane; Kinetics; Male; Myocardium; Neuraminidase; Oxotremorine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Sialic Acids | 1990 |
Effects of anticholinergic drugs on rabbit efferent phrenic discharges.
Topics: Animals; Atropine; Electrophysiology; Female; Injections, Intraventricular; Male; Phrenic Nerve; Pirenzepine; Rabbits; Respiratory Center; Scopolamine; Vagotomy | 1991 |
Regulation of histamine release and synthesis in the brain by muscarinic receptors.
Topics: Animals; Brain; Carbachol; Histamine Release; Male; Oxotremorine; Pirenzepine; Potassium; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine | 1989 |
Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacological evidence.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Animals; Blood Pressure; Hemicholinium 3; Medulla Oblongata; Microinjections; Nerve Endings; Parasympathetic Nervous System; Pirenzepine; Receptors, Muscarinic; Scopolamine; Sympathetic Nervous System | 1988 |
Muscarinic acetylcholine receptors on an identified motor neurone in the cockroach, Periplaneta americana.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Atropine; Dose-Response Relationship, Drug; Evoked Potentials; Ganglia, Invertebrate; In Vitro Techniques; Male; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Periplaneta; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine; Vertebrates | 1994 |
Facilitatory but nonessential role of the muscarinic cholinergic system in the generation of long-term potentiation of population spikes in the dentate gyrus in vivo.
Topics: Animals; Evoked Potentials; Hippocampus; Injections, Intraventricular; Long-Term Potentiation; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine | 1994 |
Effects of M1 and M2 receptor agonists and blockers on dog respiration.
Topics: Animals; Blood Gas Analysis; Dogs; Female; Male; Muscarinic Agonists; Muscarinic Antagonists; Nortropanes; Pilocarpine; Pirenzepine; Respiration; Scopolamine | 1996 |
Pharmacologic study of muscarinic receptor subtypes and arteriolar dilations: a comparison of conducted and local responses.
Topics: Animals; Arterioles; Cheek; Cricetinae; Dose-Response Relationship, Drug; Microcirculation; Mouth Mucosa; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptors, Muscarinic; Reference Values; Scopolamine; Vasodilation | 1999 |
M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse.
Topics: Acetylcholine; Animals; Male; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Pirenzepine; Prefrontal Cortex; Receptor, Muscarinic M2; Receptors, Muscarinic; Scopolamine | 2001 |
The role of cortical cholinergic pre- and post-synaptic receptors in taste memory formation.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Conditioning, Operant; Long-Term Potentiation; Male; Memory; Microdialysis; Microinjections; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Presynaptic; Scopolamine; Taste | 2003 |
Effects of anticholinergic drugs selective for muscarinic receptor subtypes on prepulse inhibition in mice.
Topics: Animals; Cholinergic Antagonists; Injections, Intraventricular; Male; Mice; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Reflex, Startle; Scopolamine; Tropicamide | 2004 |
Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory.
Topics: Animals; Catheters, Indwelling; Cerebral Cortex; Dependovirus; Fear; Gene Knockout Techniques; Genetic Vectors; Hippocampus; Immunohistochemistry; Learning; Male; Memory; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Muscarinic Antagonists; Pirenzepine; Receptors, Muscarinic; Scopolamine | 2016 |