Page last updated: 2024-09-02

afdx 116 and propranolol

afdx 116 has been researched along with propranolol in 6 studies

Compound Research Comparison

Studies
(afdx 116)
Trials
(afdx 116)
Recent Studies (post-2010)
(afdx 116)
Studies
(propranolol)
Trials
(propranolol)
Recent Studies (post-2010) (propranolol)
36712433,3103,4063,218

Protein Interaction Comparison

ProteinTaxonomyafdx 116 (IC50)propranolol (IC50)
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)0.0347
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.294
Cytochrome P450 1A2Homo sapiens (human)4
Beta-2 adrenergic receptorHomo sapiens (human)0.0114
Beta-1 adrenergic receptorHomo sapiens (human)0.0575
5-hydroxytryptamine receptor 1AHomo sapiens (human)3.9811
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.012
Cytochrome P450 2D6Homo sapiens (human)2.9706
Beta-3 adrenergic receptorHomo sapiens (human)0.0493
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0288
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0827
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0288
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.012
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.466
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.243
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0288
Sodium-dependent serotonin transporterHomo sapiens (human)0.38
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.342
5-hydroxytryptamine receptor 6Homo sapiens (human)3.065
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.017
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0288
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.828
Sodium channel protein type 5 subunit alphaHomo sapiens (human)2.1
Sodium/bile acid cotransporterHomo sapiens (human)5.5
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0288
GABA theta subunitRattus norvegicus (Norway rat)0.0288
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.87
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0288

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Horne, C; Mutschler, E; Palm, D; Pitschner, HF; Schulte, B; Volz-Zang, C; Wellstein, A1
Baskin, SI; Thomsen, RH1
Jaiswal, N; Malik, KU1
Palm, D; Pitschner, HF; Schlepper, M; Schulte, B; Wellstein, A1
Anderson, W; Dickinson, KE; Hirschowitz, BI; Matsumoto, H; Pruitt, RE; Uemura, N1
García-Sacristán, A; Prieto, D; Simonsen, U; Triguero, D1

Other Studies

6 other study(ies) available for afdx 116 and propranolol

ArticleYear
AF-DX 116, a cardioselective muscarinic antagonist in humans: pharmacodynamic and pharmacokinetic properties.
    Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:4

    Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; Male; Parasympatholytics; Pirenzepine; Propranolol; Random Allocation; Receptors, Muscarinic; Reference Values; Salivation

1991
The effects of AF-DX 116, a cardioselective muscarinic antagonist, on the negative inotropic action of acetylcholine.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 71, Issue:1

    Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Pirenzepine; Propranolol; Rabbits; Rats; Receptors, Muscarinic

1991
Prostaglandin synthesis elicited by cholinergic stimuli is mediated by activation of M2 muscarinic receptors in rabbit heart.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Arecoline; Heart; Heart Rate; Hexamethonium Compounds; Indomethacin; Male; Myocardium; Phentolamine; Pirenzepine; Propranolol; Prostaglandins; Rabbits; Receptors, Muscarinic

1988
AF-DX 116 discriminates heart from gland M2-cholinoceptors in man.
    Life sciences, 1989, Volume: 45, Issue:6

    Topics: Adult; Animals; Atropine; Blood Pressure; Cattle; Cell Membrane; Cerebral Cortex; Heart Rate; Humans; Kinetics; Male; Myocardium; N-Methylscopolamine; Organ Specificity; Pirenzepine; Propranolol; Receptors, Cholinergic; Reference Values; Saliva; Salivary Glands; Scopolamine Derivatives; Swine

1989
Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Esophagus; Imipramine; Kinetics; N-Methylscopolamine; Oxotremorine; Pepsinogens; Pirenzepine; Propranolol; Radioligand Assay; Rana catesbeiana; Receptors, Muscarinic; Scopolamine Derivatives

1988
Cholinergic modulation of non-adrenergic, non-cholinergic relaxation in isolated, small coronary arteries from lambs.
    Pflugers Archiv : European journal of physiology, 1999, Volume: 438, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholinesterase; Adrenergic alpha-Antagonists; Animals; Capsaicin; Choline O-Acetyltransferase; Coronary Vessels; Electric Stimulation; In Vitro Techniques; Microcirculation; Myography; Norepinephrine; Phentolamine; Physostigmine; Pirenzepine; Propranolol; Sheep; Suramin; Vasoconstrictor Agents; Vasodilation

1999