afdx 116 has been researched along with pirenzepine in 342 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (pirenzepine) | Trials (pirenzepine) | Recent Studies (post-2010) (pirenzepine) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 3,812 | 587 | 140 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (22.51) | 18.7374 |
| 1990's | 215 (62.87) | 18.2507 |
| 2000's | 35 (10.23) | 29.6817 |
| 2010's | 14 (4.09) | 24.3611 |
| 2020's | 1 (0.29) | 2.80 |
| Authors | Studies |
|---|---|
| Kashihara, K; Roeske, WR; Varga, EV; Waite, SL; Yamamura, HI | 1 |
| Hacksell, U; Nilsson, BM; Vargas, HM | 1 |
| Bonner, TI; Brann, MR; Buckley, CM; Buckley, NJ | 1 |
| Ellerbrock, BR; Hoss, W; Messer, WS; Smith, DA | 1 |
| Eberlein, WG; Engel, WW; Hammer, R; Mihm, G; Trummlitz, G | 1 |
| Pinkas-Kramarski, R; Sokolovsky, M; Stein, R | 1 |
| Kovacs, I; Roeske, WR; Varga, EV; Waite, SL; Yamamura, HI | 1 |
| Casida, JE; Honda, H; Tomizawa, M | 1 |
| Deaciuc, A; Dwoskin, LP; Huang, X; Siripurapu, KB; Smith, AM; Subramanian, KL; Zhan, CG; Zheng, G | 1 |
| Kashima, K; Kataoka, K; Kato, M; Kuriyama, K; Ohkuma, S | 1 |
| Narayanan, N; Su, N | 1 |
| Ishihara, H; Shimura, S | 1 |
| Crino, PB; Jensen, EL; Vogt, BA | 1 |
| Bachoo, M; Polosa, C | 1 |
| Konopka, LM; Parsons, RL | 1 |
| Egozi, Y; Koren, D; Sokolovsky, M | 1 |
| Bartolini, A; Fantetti, L; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P | 1 |
| Harada, M; Koike, K; Takayanagi, I | 1 |
| Costa, LG; Fitzgerald, BB | 1 |
| Bian, CF; Qin, W; Yu, AY; Zheng, JL | 1 |
| Aguilar, JS; Ballesta, JJ; Criado, M; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Gabelt, BT; Kaufman, PL | 2 |
| Frey, KA; Howland, MM | 1 |
| Hendriks, MG; Pfaffendorf, M; Van Zwieten, PA | 2 |
| Badini, I; Beani, L; Bianchi, C; Cintra, A; Fuxe, K; Siniscalchi, A | 1 |
| Ehlert, FJ; Thomas, EA | 3 |
| Bloom, JW; Halonen, M; Mahesh, VK; Nunan, LM; Palmer, JD; Yamamura, HI | 1 |
| Fernandes, LB; Fryer, AD; Hirshman, CA | 1 |
| Funakoshi, A; Jimi, A; Kono, A; Tateishi, K; Tsuru, M; Wakasugi, H | 1 |
| Anderson, DJ; Connolly, T; McKinney, M; Miller, JH; Vella-Rountree, L | 1 |
| Buyse, MA; Fraeyman, NH; Lefebvre, RA | 1 |
| Challiss, RA; Nahorski, SR; Whitham, EM | 1 |
| Böhm, M; Erdmann, E; Gengenbach, S; Hauck, RW; Sunder-Plassmann, L | 1 |
| Jiang, ZG; North, RA; Sugita, S; Uchimura, N | 1 |
| Kimura, T; Satoh, S; Shimamura, T | 1 |
| Bhattacharya, SK; Das Gupta, G; Sen, AP; Seth, K; Seth, PK | 1 |
| Gies, JP; Haddad, EB; Landry, Y | 1 |
| Bindslev, N; Winding, B | 1 |
| Daniel, EE; Janssen, LJ | 1 |
| Choo, LK; Mitchelson, F | 1 |
| Kimura, T; Mukaiyama, O; Satoh, S; Takeuchi, A | 1 |
| Atkins, PT; Kitai, ST; Nishi, K; Surmeier, DJ | 1 |
| Matsumoto, K; Pappano, AJ | 1 |
| Inoue, M; Kuriyama, H | 1 |
| Donoff, B; Lad, R; Rangachari, PK | 1 |
| Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E; Tacke, R | 1 |
| Nishimura, S; Sorimachi, M; Yamagami, K | 1 |
| Boddeke, HW | 1 |
| Alonso, MJ; Arribas, S; Balfagón, G; Marín, J; Salaices, M | 1 |
| Dowdall, MJ; Green, AC | 1 |
| Myers, AC; Undem, BJ | 1 |
| Buxton, IL; Horowitz, B; Zhang, LB | 1 |
| Aikawa, T; Itabashi, S; Ohrui, T; Sasaki, H; Sekizawa, K; Takishima, T | 1 |
| Igarashi, M; Komiya, Y; Saito, S | 1 |
| Akaike, N; Harata, N; Tateishi, N | 1 |
| Bian, CF; Hong, XM; Yin, XX; Zhou, J | 1 |
| Chiba, S; Furukawa, Y; Nakane, T | 1 |
| Angelucci, L; Ghirardi, O; Imperato, A; Ramacci, MT; Scrocco, MG | 1 |
| Fujimoto, K; Hayakawa, T; Kashima, Y; Kawashima, K; Oohata, H; Suzuki, T | 1 |
| Tang, LC | 1 |
| Birdsall, NJ; Eveleigh, P; Hulme, EC; Pedder, EK; Poyner, D | 1 |
| Low, PA; Torres, NE; Zollman, PJ | 1 |
| Hersey, SJ; Kajimura, M; Sachs, G; Scott, DR; Wilkes, JM | 1 |
| Horne, C; Mutschler, E; Palm, D; Pitschner, HF; Schulte, B; Volz-Zang, C; Wellstein, A | 1 |
| Benedito, S; García-Sacristán, A; Hernández, M; Prieto, D; Rivera, L | 1 |
| Richards, MH | 1 |
| Aceves, J; Brassart, JL; Góngora-Alfaro, JL; Hernández-López, S; Martínez-Fong, D | 1 |
| Gibson, VA; McKinney, M; Miller, JH | 1 |
| Olianas, MC; Onali, P | 1 |
| Boselli, C; Kenakin, TP | 1 |
| Lawrence, R; Oktay, A; Oktay, S; Onat, FY; Yegen, BC | 1 |
| Bird, ED; Crino, PB; Plager, MD; Vogt, BA | 1 |
| Bernardini, MC; Blandizzi, C; Danesi, R; Del Tacca, M | 1 |
| Chiba, S; Tsukada, M | 1 |
| Annis, SJ; Ehlert, FJ; Leslie, FM; Smith, TD | 1 |
| Borkowski, JA; Buck, MA; Mallon, RG; McQuade, RD; Pai, JK; Pepitoni, S | 1 |
| Blaxall, HS; Cunningham, J; Gardier, RW; Killian, LN | 1 |
| Baskin, SI; Thomsen, RH | 1 |
| Baron, E; Boer, R; Eltze, M; Kromer, W | 1 |
| Doods, H; Entzeroth, M; Mayer, N | 1 |
| Kaneda, T; Kitamura, Y; Nomura, Y | 1 |
| Bast, A; Doelman, CJ; Nagtegaal, JE; Rodrigues de Miranda, JF; Sprong, RC | 1 |
| Davidson, A; Matus-Leibovitch, N; Mengod, G; Oron, Y | 1 |
| Chiba, S; Furukawa, Y; Karasawa, Y; Murakami, M; Narita, M; Ren, LM; Takei, M | 1 |
| Alger, BE; Pitler, TA | 1 |
| Altes, U; Forsyth, KM; Habermeier-Muth, A; Muscholl, E | 1 |
| Danilo, P; Rosen, MR; Steinberg, SF | 1 |
| Li, AH; Nattie, EE | 1 |
| Elzinga, CR; Roffel, AF; Zaagsma, J | 1 |
| Harbon, S; Leiber, D; Marc, S | 1 |
| Fleming, N; Laniyonu, A; Sliwinski-Lis, E | 1 |
| Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J | 3 |
| Bloom, JW; Lai, J; Roeske, WR; Yamamura, HI | 1 |
| Bonner, TI; Brann, MR; Wess, J | 1 |
| Hayashi, S; Kitamura, Y; Nomura, Y | 1 |
| Entzeroth, M; Mayer, N | 1 |
| Hanack, C; Herawi, M; Kopp, R; Lambrecht, G; Moser, U; Mutschler, E; Pfeiffer, A; Tacke, R | 1 |
| Bohnett, M; Messer, WS; Stibbe, J | 1 |
| Ehlert, FJ; Tran, LP | 1 |
| Giraldo, E; Ladinsky, H; Monferini, E; Schiavi, GB | 1 |
| Ashe, JH; Olito, AC; Yarosh, CA | 2 |
| Fujimoto, K; Kawashima, K; Oohata, H; Suzuki, T | 1 |
| Michel, AD; Whiting, RL | 2 |
| Costi, A; Marchi, M; Raiteri, M; Volpe, G | 1 |
| Coppes, RP; Meurs, H; Remie, R; Roffel, AF; Zaagsma, J | 1 |
| Delen, FM; Ehlert, FJ; Liem, HA; Yun, SH | 1 |
| Haga, T; Honda, N; Ichiyama, A; Kajimura, M; Kaneko, E | 1 |
| Bagetta, G; Constanti, A | 1 |
| Jackson, KN; Kachur, JF; Lowe, VC; Noronha-Blob, L; Sturm, BL | 1 |
| Allen, TG; Burnstock, G | 1 |
| De Boer, P; Horn, AS; Rollema, H; Westerink, BH; Zaagsma, J | 1 |
| Araujo, DM; Collier, B; Lapchak, PA; Meaney, MJ; Quirion, R | 1 |
| Packard, MG; Quirion, R; Regenold, W; White, NM | 1 |
| el-Fakahany, EE; Fryer, AD | 2 |
| Ackerman, MS; Korc, M; Roeske, WR | 1 |
| Kobayashi, H; Mochida, S | 2 |
| Goode, TL; Mathiasen, JR; Raffa, RB; Vaught, JL | 1 |
| Jaiswal, N; Malik, KU | 1 |
| Daemmgen, JW; Gross, GJ; Pelc, LR; Warltier, DC | 1 |
| Duckles, SP | 1 |
| Arrang, JM; Gulat-Marnay, C; Lafitte, A; Schwartz, JC | 1 |
| Galvan, M | 1 |
| Murugaian, J; Sapru, H; Sundaram, K; Watson, M | 1 |
| Goritski, W; Mega, A; Nattie, EE; Wood, J | 1 |
| Eglen, RM; Michel, AD; Whiting, RL | 1 |
| Anderson, D; el-Fakahany, EE; Forray, C; McKinney, M | 1 |
| Kopp, R; Lambrecht, G; Moser, U; Mutschler, E; Pfeiffer, A; Tacke, R | 1 |
| Fraser, CM; Gocayne, JD; Robinson, DA; Venter, JC; Wang, CD | 1 |
| Marchi, M; Raiteri, M | 1 |
| Micheletti, R; Prudentino, A; Schiavone, A | 1 |
| Kito, S; Miyoshi, R; Shimoyama, M | 1 |
| Gehlert, DR; Hawkins, KN; Roeske, WR; Wang, JX; Yamamura, HI | 1 |
| Connolly, GP; Newberry, NR | 1 |
| Gilbert, MJ; Newberry, NR | 1 |
| Dammann, F; Fuder, H; Giachetti, A; Giraldo, E; Kilbinger, H; Micheletti, R | 1 |
| Chiba, S; Haruta, K; Homma, N; Horiuchi, A; Iwatsuki, K; Yonekura, H | 1 |
| Kato, T; Mizobe, F; Xu, M; Yamamoto, T | 1 |
| Ghataorre, AS; Lambert, DG; Nahorski, SR | 1 |
| Palm, D; Pitschner, HF; Schlepper, M; Schulte, B; Wellstein, A | 1 |
| Boer, R; Galvan, M; Schudt, C | 1 |
| Araujo, DM; Lapchak, PA; Quirion, R; Regenold, W | 1 |
| Araujo, DM; Quirion, R; Regenold, W | 1 |
| Araujo, DM; Collier, B; Lapchak, PA; Quirion, R | 2 |
| Michel, AD; Stefanich, E; Whiting, RL | 1 |
| Delen, FM; Ehlert, FJ; Friedman, DJ; Self, DW; Yun, SH | 1 |
| Brown, DA; Marrion, NV; Marsh, SJ; Smart, TG | 1 |
| Canning, B; Costello, D; Kinnier, WJ; Noronha-Blob, L | 1 |
| Londong, W | 1 |
| Giachetti, A; Micheletti, R; Montagna, E | 2 |
| Kunysz, EL; Michel, AD; Whiting, RL | 1 |
| Anderson, W; Dickinson, KE; Hirschowitz, BI; Matsumoto, H; Pruitt, RE; Uemura, N | 1 |
| Henquin, JC; Nenquin, M | 1 |
| De Conti, L; Giraldo, E; Hammer, R; Ladinsky, H; Micheletti, R; Monferini, E; Schiavi, GB; Viganò, MA | 1 |
| Camus, J; Christophe, J; Waelbroeck, M; Winand, J | 1 |
| Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E | 1 |
| Ruigt, GS; Tonnaer, JA; Van Wezenbeek, LA | 1 |
| Camus, J; Christophe, J; De Neef, P; Fourmy, D; Pradayrol, L; Robberecht, P; Scemama, JL; Tastenoy, M; Vaysse, N; Waelbroeck, M | 1 |
| Bonner, TI; Brann, MR; Buckley, NJ; Young, AC | 1 |
| Krieger, AJ; Sapru, H; Sundaram, K | 1 |
| Herawi, M; Lambrecht, G; Moser, U; Mutschler, E; Pfeiffer, A | 1 |
| Lui, GK; Mei, L; Roeske, WR; Serra, M; Watson, M; Yamamura, HI | 1 |
| Davidesko, D; Doods, HN; Rinner, I; van Charldorp, KJ; van Zwieten, PA | 1 |
| Chung, FZ; Lai, J; Mei, L; Roeske, WR; Venter, JC; Yamamura, HI | 1 |
| Giraldo, E; Hammer, R; Ladinsky, H; Viganò, MA | 1 |
| Akiba, I; Bujo, H; Kubo, T; Maeda, A; Mishina, M; Nakai, J; Numa, S | 1 |
| Nilvebrant, L; Sparf, B | 1 |
| Sapru, H; Sundaram, K | 1 |
| Araujo, D; Quirion, R; Regenold, W | 1 |
| Duckles, SP; Lee, V; Yamamura, HI | 1 |
| Bloom, JW; Halonen, M; Seaver, NA; Yamamura, HI | 1 |
| Davidesko, D; de Jonge, A; Doods, HN; Mathy, MJ; van Charldorp, KJ; van Zwieten, PA | 1 |
| de Zeeuw, RA; in't Hout, WG; Roffel, AF; Zaagsma, J | 1 |
| Gulya, K; Roeske, WR; Wang, JX; Wang, W; Yamamura, HI | 1 |
| Roeske, WR; Wang, JX; Wang, W; Yamamura, HI | 1 |
| Giraldo, E; Hammer, R; Ladinsky, H; Monferini, E | 1 |
| Smith, TL; Yamamura, HI | 1 |
| De Paoli, AM; Giraldo, E; Hammer, R; Martos, F; Monferini, E | 1 |
| Giraldo, E; Hammer, R; Ladinsky, H; Monferini, E; Schiavi, GB | 1 |
| Giraldo, E; Hammer, R; Ladinsky, H | 1 |
| Chiba, S; Nakane, T; Ren, LM | 1 |
| Bai, D; Sattelle, DB | 1 |
| Imaizumi, Y; Kawai, T; Masuda, Y; Ryang, S; Tanaka, M; Watanabe, M; Yamahara, NS | 1 |
| Baird, AW; Farrell, CB; O'Boyle, KM; O'Malley, KE | 1 |
| Amenta, F; Giannella, M; Liu, A; Pigini, M; Tayebati, SK; Zaccheo, D | 1 |
| Bacman, S; Borda, E; Camusso, JJ; Rodriguez, M; Sterin-Borda, L | 1 |
| Baylis, HA; Bunting, R; Mason, WT; Millar, NS; Reaper, C; Sattelle, DB | 1 |
| Bellido, I; Fernández, JL; Gómez, A; Sánchez de la Cuesta, F | 1 |
| Kondo, S; Morita, T; Tashima, Y | 1 |
| Bruning, TA; Chang, PC; Hendriks, MG; Pfaffendorf, M; van Zwieten, PA; Vermeij, P | 1 |
| Dietrich, C; Kilbinger, H | 1 |
| Boselli, C; Grana, E | 1 |
| Burgard, EC; Cote, TE; Sarvey, JM | 1 |
| Marks, GA; Roffwarg, HP | 1 |
| Gabelt, BT; Kaufman, PL; Poyer, JF | 1 |
| Fukui, H; Inagaki, N; Kondou, H | 1 |
| Bouaziz, H; Eisenach, JC; Tong, C | 1 |
| Imaizumi, Y; Tanaka, M; Watanabe, M; Yamahara, NS | 1 |
| Hamstra, JJ; Roffel, AF; Santing, RE; ten Berge, RE; Zaagsma, J | 1 |
| Doods, HN; van Zwieten, PA | 1 |
| Suslova, IV | 1 |
| Robinson, NE; Wang, ZW; Yu, MF | 1 |
| Haass, M; Haunstetter, A; Krüger, C; Kübler, W; Yi, X | 1 |
| Gillman, TA; Mitchelson, F; Pennefather, JN | 1 |
| Amenta, F; Liu, A; Zaccheo, D; Zeng, YC | 1 |
| Neuzner, J; Palm, D; Pitschner, HF; Schlepper, M; Schulte, B; Wellstein, A | 1 |
| Kotlikoff, MI; Kume, H; Mikawa, K; Takagi, K | 1 |
| Jakubík, J; Tucek, S | 1 |
| Furukawa, N; Okada, H; Qu, RY | 1 |
| Akaike, N; Furukawa, K; Nabekura, J | 1 |
| Anthony, TL; Kreulen, DL | 1 |
| Cynader, MS; Drance, SM; Gupta, N; McAllister, R; Rootman, J | 1 |
| Bouaziz, H; Detweiler, DJ; Eisenach, JC; Li, P; Lothe, A; Tong, C; Yoon, Y | 1 |
| Abe, K; Mizutani, A; Nakata, A; Saito, H | 1 |
| Maeda, T; Satoh, M | 1 |
| Bian, CF; Qin, W; Yao, B; Zheng, JL | 1 |
| Dauphin, F; Hamel, E; Linville, DG | 1 |
| Altiere, RJ; Roberts, J; Thompson, DC; Travis, DC | 1 |
| Davenport, TA; Fukumoto, Y; Gousse, A; Kamai, T; Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Huang, Q; Li, A; Mills, J; Nattie, EE | 1 |
| Allescher, HD; Classen, M; Kurjak, M; Schusdziarra, V | 1 |
| Kaneko, S; Maeda, T; Satoh, M | 1 |
| Aslan, AN; Oktay, S; Onat, F; Ozkutlu, U | 1 |
| Baghdoyan, HA; Carlson, BX; Roth, MT | 1 |
| Bruning, TA; Chang, PC; Hendriks, MG; Kuypers, EA; van Zwieten, PA | 1 |
| Chen, FF; Hsu, HF; Sung, TC; Wu, D; Yang, CM | 1 |
| Baratti, CM; Kopf, SR; Opezzo, JW | 1 |
| Doods, H; Eberlein, W; Engel, W; Entzeroth, M; Mihm, G; Rudolf, K; Schiavi, G; Ziegler, H | 1 |
| Greten, H; Mirau, S; Raedler, A; Sievers, J; von Schrenck, T | 1 |
| Chuang, DM; Fukamauchi, F; Hough, C; Saunders, PA | 1 |
| Hirano, S; Kondo, S; Morita, T | 1 |
| Christopoulos, A; Loiacono, R; Mitchelson, F | 1 |
| Wills-Karp, M | 1 |
| Chen, J; Feldmann, BJ; Woldemussie, E | 1 |
| Andrioli, GC; Cavazzani, P; Marchi, M; Raiteri, M; Russo, C | 1 |
| Baker, SA; Ehlert, FJ; Thomas, EA | 1 |
| Cappello, B; Di Carlo, R; Greco, G; Meli, R; Muccioli, G; Novellino, E; Perissutti, E; Santagada, V; Silipo, C; Vittoria, A | 1 |
| Baumgold, J; Cohen, VI; De La Cruz, R; Jin, B; Reba, RC; Rzeszotarski, WJ | 1 |
| Frey, KA; Zubieta, JK | 1 |
| Consolo, S; Garcia Ruiz, AJ; La Porta, C; Ladinsky, H; Zambelli, M | 1 |
| Cosentino, M; Crema, A; D'Angelo, L; de Ponti, F; Einaudi, A; Frigo, GM; Lecchini, S | 1 |
| Bechtel, WD; Doods, HN; Engel, W; Ensinger, HA; Entzeroth, M; Ladinsky, H; Mihm, G; Quirion, R; Rudolf, K; Schiavi, GB | 1 |
| Garssen, J; Gierveld, CM; Nijkamp, FP; Van der Vliet, H; Van Loveren, H | 1 |
| Bacáková, L; el-Fakahany, EE; Jakubík, J; Tucek, S | 1 |
| Garland, CJ; Hillier, K; Kerr, PM; Wallis, RM | 1 |
| Borda, E; Echagüe, AV; Genaro, A; Leiros, CP; Sterin-Borda, L | 1 |
| Hoss, W; Messer, WS; Periyasamy, S; Roknich, S; Sauerberg, P | 1 |
| Nomura, Y; Ohnuki, T | 1 |
| Barahona, MV; Sánchez-Fortún, S; Sanz, F | 1 |
| Bellanger, C; Boutin, H; Chevalier, C; Dauphin, F; MacKenzie, ET; Mickala, P | 1 |
| Anderson, JW; Brundage, KL; Fisher, JT | 1 |
| Ehlert, FJ; Ostrom, RS | 2 |
| Arana, R; Bacman, S; Borda, E; Camusso, JJ; Hubscher, O; Sterin-Borda, L | 1 |
| Akaike, A; Kaneko, S; Maeda, T; Satoh, M; Shimoshige, Y | 1 |
| Akaishi, Y; Hattori, Y; Kanno, M; Kitabatake, A; Sakuma, I | 1 |
| Aslan, N; Gören, Z; Oktay, S; Onat, F; Ozkutlu, U | 1 |
| Hanai, H; Kajimura, M; Kaneko, E; Kodaira, M; Lin, S; Takeuchi, K | 1 |
| Haga, N; Itoh, Z; Mizumoto, A; Satoh, M; Yamada, T | 1 |
| Belmonte, KE; Fryer, AD; Jacoby, DB | 1 |
| Matthews, MR; Zaidi, ZF | 1 |
| Egerland, U; Kaverina, NV; Lichoscherstow, A; Lyskovzev, VV; Poppe, H; Rüger, C; Sauer, W; Skoldinow, A | 1 |
| Ehlert, FJ; Sawyer, GW | 2 |
| Alfonzo, MJ; de Alfonzo, RG; de Becemberg, IL; de Herrera, VN; de Villaroel, SS; Misle, AJ | 1 |
| Hirano, S; Kakefuda, A; Shibata, H; Takizawa, K; Tanaka, A; Watanabe, T; Yamagiwa, Y; Yanagisawa, I | 1 |
| Go, ML; Sim, MK; Xu, R | 1 |
| Komori, S; Nakayama, T; Ohashi, H; Unno, T | 1 |
| Islam, MA; Kimura, I; Nojima, H | 1 |
| Baratti, CM; Boccia, MM; Kopf, SR | 1 |
| Bian, CF; Ge, XQ; Qin, W; Yao, B; Zheng, JL | 1 |
| Mitchelson, F; Shen, A | 1 |
| Backman, SB; Collier, B; Polosa, C; Stein, RD | 1 |
| Furukawa, Y; Hashimoto, K; Naito, H | 1 |
| Bargas, J; Galarraga, E; Hernández-Echeagaray, E | 1 |
| Rivers, RJ | 1 |
| Bargas, J; Bermudez-Rattoni, F; Galarraga, E; Hernández-López, S; Miranda, I; Reyes, A; Vilchis, C | 1 |
| DeLapp, NW; Falcone, J; Felder, CC; McClure, D; McKinzie, JH; Sawyer, BD; Vandergriff, A | 1 |
| Motomura, S; Sasaki, S | 1 |
| García-Sacristán, A; Prieto, D; Simonsen, U; Triguero, D | 1 |
| Cohen, ML; Gomeza, J; Stengel, PW; Wess, J | 1 |
| Ehlert, FJ; Lambrecht, G; Sawyer, GW | 1 |
| Fitzgerald, RS; Shirahata, M; Wang, HY | 1 |
| Höhle, KD; Möhlig, T; Reinheimer, T; Wessler, I; Zimmermann, S | 1 |
| Fushimi, T; Masuda, T; Saitoh, H; Shimura, S; Shirato, K | 1 |
| Qian, JQ; Zhong, N | 1 |
| Kwon, SC | 1 |
| Christopoulos, A; Lanzafame, A; Mitchelson, F | 1 |
| De Iuri, L; Imbrogno, S; Mazza, R; Tota, B | 1 |
| Funakami, Y; Hata, T; Ishida, K; Itoh, E; Uchida, S | 1 |
| Baghdoyan, HA; Douglas, CL; Lydic, R | 2 |
| Gerthoffer, WT; Singer, CA; Vang, S | 1 |
| Fu, ML; Hayase, M; Katsuda, S; Kurihara, T; Matsui, S; Takekoshi, N; Teraoka, K; Yamaguchi, N | 1 |
| Fu, ML; Matsui, S | 1 |
| Cohen, ML; Stengel, PW | 1 |
| Kato, T; Ogasawara, M; Sato, K; Shimoda, N; Sugaya, K | 1 |
| Albuquerque, EX; Aracava, Y; Castro, NG; Fawcett, WP; Pereira, EF; Randall, WR; Santos, MD | 1 |
| Bermúdez-Rattoni, F; Escobar, ML; Espinosa, E; Miranda, MI; Ramírez-Lugo, L | 1 |
| Hosoi, T; Nomura, J; Nomura, Y; Okuma, Y | 1 |
| Mamiya, T; Okuda, A; Ukai, M | 1 |
| Crittenden, EL; García, DM; González, A | 1 |
| Bukharaeva, EA; Magazanik, LG; Nikolsky, EE; Samigullin, D; Vyskocil, F | 1 |
| Doi, Y; Hayashi, H; Kaibara, M; Murasaki, O; Taniyama, K; Uezono, Y; Yano, K | 1 |
| Althaus, H; Marti, M; Mevissen, M; Steiner, A | 1 |
| de Groat, WC; Ng, YK; Wu, HY | 1 |
| Cao, J; Hashiba, K; Kitazawa, T; Komori, S; Taneike, T; Unno, T; Wess, J; Yamada, M | 1 |
| Arreola, JL; Chávez, J; Flores-Soto, E; Montaño, LM; Segura, P; Vargas, MH | 1 |
| Hirose, K; Kaeriyama, S; Muramatsu, A; Nouchi, H; Sato, M; Shigenobu, K; Shimizu, N; Tanaka, H | 1 |
| McGowan, SE | 1 |
| Mevissen, M; Meylan, M; Pfeiffer, JB; Portier, CJ; Steiner, A | 1 |
| Ehlert, FJ; Figueroa, KW; Griffin, MT; Liller, S | 1 |
| Endoh, T | 1 |
| Mohler, EG; Palencia, CA; Prior, M; Ragozzino, ME; Rozman, S | 1 |
| Blackstone, K; Pratt, WE | 1 |
| Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A | 1 |
| Brenner, R; Herlihy, JT; Semenov, I; Wang, B | 1 |
| Kajioka, S; Naito, S; Seki, N; Shahab, N | 1 |
| Choisy, SC; Hancox, JC; James, AF | 1 |
| Dehnicke, C; Deisz, RA; Gigout, S; Horn, P; Lehmann, TN; Wierschke, S | 1 |
| Barnes, PJ; Brown, SM; Donnelly, LE; Koarai, A; Nicholson, AG; Sturton, RG | 1 |
| Arrighi, N; Bodei, S; Cosciani Cunico, S; Michel, MC; Sigala, S; Simeone, C; Spano, P; Zani, D | 1 |
| Barathi, VA; Beuerman, RW; Goh, LK; Kwan, JL; Seet, LF; Tan, QS; Vithana, EN; Weon, SR | 1 |
| Anderson, RW; Strowbridge, BW | 1 |
| Chen, SR; Pan, HL; Zhu, Y | 1 |
| Chen, HJ; Corcoran, KA; Guedea, AL; Jovasevic, V; Leaderbrand, K; Radulovic, J; Wess, J | 1 |
| Buyukafsar, K; Cevik, OS; Koyuncu, DD; Sahin, L | 1 |
| Hassanpour, S; Lankarani Mohajer, L; Zendehdel, M | 1 |
| Geng, B; Li, M; Liu, L; Wang, Z | 1 |
7 review(s) available for afdx 116 and pirenzepine
| Article | Year |
|---|---|
Pharmacology and second messenger interactions of cloned muscarinic receptors.
Topics: Animals; Atropine; Carbachol; Cell Line; Humans; Oxotremorine; Piperidines; Pirenzepine; Receptors, Muscarinic; Recombinant Proteins; Second Messenger Systems; Transfection | 1991 |
Pharmacological muscarinic receptor subtypes.
Topics: Animals; Binding, Competitive; Brain; Organ Specificity; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1990 |
Cardioselective muscarinic antagonists.
Topics: Animals; Carbachol; Cardiotonic Agents; Carrier Proteins; Cyclic AMP; Cyclic AMP Receptor Protein; Dose-Response Relationship, Drug; Heart; N-Methylscopolamine; Oxotremorine; Phorbol Esters; Pirenzepine; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Muscarinic receptor heterogeneity in smooth muscle: binding and functional studies with AF-DX 116.
Topics: Animals; Humans; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic | 1988 |
Muscarinic receptors and drugs in cardiovascular medicine.
Topics: Bradycardia; Cardiovascular Diseases; Cholinergic Agents; Endothelium, Vascular; Humans; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth, Vascular; Nitric Oxide; Parasympatholytics; Pirenzepine; Quinuclidines; Receptors, Muscarinic; Regression Analysis; Structure-Activity Relationship | 1995 |
[Subtypes of muscarinic receptors--aspects of their physiologic significance for controlling heart rate in the human].
Topics: Atropine; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Heart Rate; Humans; Parasympatholytics; Pirenzepine; Radioligand Assay; Receptors, Muscarinic | 1994 |
Therapeutic potential of CNS-active M2 antagonists: novel structures and pharmacology.
Topics: Animals; Benzodiazepinones; Brain; CHO Cells; Cognition Disorders; Cricetinae; Dibenzazepines; Drug Design; Motor Activity; Parasympatholytics; Piperidines; Pirenzepine; Pyridines; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1993 |
1 trial(s) available for afdx 116 and pirenzepine
| Article | Year |
|---|---|
In vivo characterization of muscarinic receptor subtypes that mediate vasodilatation in patients with essential hypertension.
Topics: Atropine; Forearm; Humans; Hypertension; Male; Methacholine Chloride; Middle Aged; Nitroprusside; Parasympatholytics; Pirenzepine; Plethysmography; Receptors, Muscarinic; Vasodilation | 1995 |
334 other study(ies) available for afdx 116 and pirenzepine
| Article | Year |
|---|---|
Cloning of the rat M3, M4 and M5 muscarinic acetylcholine receptor genes by the polymerase chain reaction (PCR) and the pharmacological characterization of the expressed genes.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Fibroblasts; Gene Expression; Inositol Phosphates; Molecular Sequence Data; Parasympatholytics; Polymerase Chain Reaction; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Muscarinic; Transfection | 1992 |
Amide, urea, and carbamate analogues of the muscarinic agent [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Blood Pressure; Denervation; Ganglia; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscles; Parasympathomimetics; Pirenzepine; Rabbits; Ranidae; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Structure-Activity Relationship; Substrate Specificity | 1992 |
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
Topics: Animals; Cell Line; Cloning, Molecular; Cricetinae; Humans; Kinetics; N-Methylscopolamine; Parasympatholytics; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations.
Topics: Animals; Autoradiography; Brain; Computer Simulation; Diencephalon; Mesencephalon; Molecular Conformation; Molecular Structure; Muscarine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Rhombencephalon; Structure-Activity Relationship; Telencephalon; Thermodynamics; Tissue Distribution | 1989 |
Tricyclic compounds as selective muscarinic receptor antagonists. 3. Structure-selectivity relationships in a series of cardioselective (M2) antimuscarinics.
Topics: Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Myocardium; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1989 |
Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Atropine; Carbachol; Cell Line; Cloning, Molecular; GTP-Binding Proteins; Oxotremorine; Phosphatidylinositols; Rats; Receptors, Muscarinic; Recombinant Proteins | 1988 |
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
Topics: Amino Acid Sequence; Animals; Carbachol; Cloning, Molecular; Cyclic AMP; Humans; Mice; Molecular Sequence Data; Muscarinic Agonists; Muscarinic Antagonists; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Muscarinic; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity | 1998 |
Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists.
Topics: Animals; Brain; Drosophila; Houseflies; Insecta; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tritium | 2007 |
Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.
Topics: Animals; CHO Cells; Corpus Striatum; Cricetinae; Cricetulus; Dopamine; Esters; Humans; In Vitro Techniques; Molecular Docking Simulation; Muscarinic Agonists; Oxotremorine; Pyridines; Radioligand Assay; Rats; Receptor, Muscarinic M5; Structure-Activity Relationship | 2013 |
Characterization of muscarinic receptor subtypes on rat pancreatic acini: pharmacological identification by secretory responses and binding studies.
Topics: Amylases; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Male; Pancreas; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Sincalide | 1992 |
Enhanced chronotropic and inotropic responses of rat myocardium to cholinergic stimulus with aging.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Carbachol; Heart; Heart Rate; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Proteins; Myocardial Contraction; Myocardium; Parasympathetic Nervous System; Parasympatholytics; Parasympathomimetics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred F344 | 1992 |
[The role of muscarinic receptor subtypes in feline tracheal submucosal gland secretion].
Topics: Animals; Atropine; Calcium; Cats; Electrolytes; Glycoproteins; In Vitro Techniques; Mucous Membrane; Piperidines; Pirenzepine; Receptors, Muscarinic; Second Messenger Systems; Trachea | 1992 |
Multiple heteroreceptors on limbic thalamic axons: M2 acetylcholine, serotonin1B, beta 2-adrenoceptors, mu-opioid, and neurotensin.
Topics: Atenolol; Autoradiography; Axons; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethanolamines; Limbic System; Neurotensin; Oxotremorine; Pindolol; Pirenzepine; Receptors, Adrenergic, beta; Receptors, Muscarinic; Receptors, Neurotensin; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, mu; Receptors, Serotonin; Thalamus; Tritium | 1992 |
An AF-DX 116 sensitive inhibitory mechanism modulates nicotinic and muscarinic transmission in cat superior cervical ganglion in the presence of anticholinesterase.
Topics: Action Potentials; Animals; Cats; Cholinesterase Inhibitors; Ganglia, Sympathetic; Hexamethonium Compounds; Parasympatholytics; Parasympathomimetics; Physostigmine; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission | 1992 |
Bethanechol-induced responses in mudpuppy parasympathetic neurons.
Topics: Animals; Bethanechol; Bethanechol Compounds; Ganglia, Parasympathetic; Membrane Potentials; Necturus; Neurons; Parasympatholytics; Pirenzepine; Receptors, Nicotinic | 1992 |
Muscarinic involvement in the regulation of gonadotropin-releasing hormone in the cyclic rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Diamines; Estrus; Female; Gonadotropin-Releasing Hormone; Median Eminence; Muscarinic Antagonists; Norepinephrine; Parasympatholytics; Pirenzepine; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Secretory Rate; Serotonin Antagonists | 1992 |
Role of muscarinic receptor subtypes in central antinociception.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesia; Animals; Male; Mice; Pain Measurement; Pirenzepine; Quinuclidines; Receptors, Muscarinic; Thiophenes | 1992 |
Characterization of subtype of propylbenzilylcholine mustard (PrBCM)-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle.
Topics: 4-Aminopyridine; Alkaloids; Animals; Drug Resistance; Furans; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; Muscle, Smooth; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Propylbenzilylcholine Mustard; Receptors, Muscarinic; Sensitivity and Specificity | 1992 |
Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats.
Topics: Animals; Brain; Disulfoton; Male; Organophosphorus Compounds; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tritium | 1992 |
[Muscarinic receptor subtypes in respiratory center and their functions].
Topics: Animals; Atropine; Blood Gas Analysis; Female; Male; Medulla Oblongata; Pilocarpine; Pirenzepine; Pons; Rabbits; Radioligand Assay; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, Muscarinic; Respiration; Respiratory Center; Scopolamine; Tidal Volume | 1992 |
Muscarinic receptor subtypes in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Dicyclomine; Muscarine; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1992 |
Inhibition of outflow facility and accommodative and miotic responses to pilocarpine in rhesus monkeys by muscarinic receptor subtype antagonists.
Topics: Accommodation, Ocular; Animals; Aqueous Humor; Female; Intraocular Pressure; Macaca mulatta; Male; Miosis; Muscarinic Antagonists; Parasympatholytics; Phenylephrine; Pilocarpine; Piperidines; Pirenzepine; Pupil | 1992 |
Quantitative autoradiography of muscarinic cholinergic receptor binding in the rat brain: distinction of receptor subtypes in antagonist competition assays.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Male; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine | 1992 |
Characterization of the muscarinic receptor subtype mediating vasodilation in the rat perfused mesenteric vascular bed preparation.
Topics: Animals; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Methacholine Chloride; Parasympatholytics; Perfusion; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Vasodilation | 1992 |
Muscarinic modulation of acetylcholine release from slices of guinea pig nucleus basalis magnocellularis.
Topics: Acetylcholine; Animals; Atropine; Calcium; Choline; Female; Guinea Pigs; Male; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Receptors, Muscarinic; Substantia Innominata; Tetrodotoxin | 1992 |
Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo.
Topics: Alkylating Agents; Animals; Diphenylacetic Acids; Male; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
A minority of muscarinic receptors mediate rabbit tracheal smooth muscle contraction.
Topics: Animals; Atropine; Female; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myocardium; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Radioligand Assay; Receptors, Muscarinic; Trachea | 1992 |
M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.
Topics: Animals; Dogs; Drug Interactions; Isoproterenol; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1992 |
Acetylcholine regulates pancreastatin secretion from the human pancreastatin-producing cell line (QGP-1N).
Topics: Acetylcholine; Adenoma, Islet Cell; Atropine; Calcimycin; Calcium; Carbachol; Chromogranin A; Gastrin-Releasing Peptide; Humans; Pancreatic Hormones; Pancreatic Neoplasms; Parasympatholytics; Peptides; Piperidines; Pirenzepine; Receptors, Muscarinic; Sincalide; Tumor Cells, Cultured | 1991 |
Pharmacological profiles for rat cortical M1 and M2 muscarinic receptors using selective antagonists: comparison with N1E-115 muscarinic receptors.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Diamines; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Phenethylamines; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Tumor Cells, Cultured | 1991 |
Study of the muscarinic receptor subtypes in N1E 115 mouse neuroblastoma cells.
Topics: Animals; Carbachol; Cyclic AMP; Cyclic GMP; Indicators and Reagents; Ligands; Mice; Neuroblastoma; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tumor Cells, Cultured | 1991 |
M3 muscarinic cholinoceptors are linked to phosphoinositide metabolism in rat cerebellar granule cells.
Topics: Animals; Animals, Newborn; Binding, Competitive; Carbachol; Cerebellum; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Male; Parasympatholytics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Beta-adrenergic receptors and m-cholinergic receptors in human lung. Findings following in vivo and in vitro exposure to the beta-adrenergic receptor agonist, terbutaline.
Topics: Aged; Aged, 80 and over; Airway Obstruction; Dose-Response Relationship, Drug; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lung; Middle Aged; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Adrenergic, beta; Receptors, Cholinergic; Terbutaline | 1991 |
Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain; Corpus Striatum; Diamines; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Kinetics; Muscarine; Neurons; Nucleus Accumbens; Organ Specificity; Parasympatholytics; Pirenzepine; Quinoxalines; Rats; Receptors, Muscarinic; Synapses | 1991 |
Effects of pirenzepine, AF-DX 116 and gallamine on the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation: interaction of M1 and M2 receptors with nicotinic receptors.
Topics: Adrenal Glands; Animals; Catecholamines; Dogs; Electric Stimulation; Female; Gallamine Triethiodide; Hexamethonium; Hexamethonium Compounds; Male; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Splanchnic Nerves | 1991 |
Central muscarinic receptor subtypes and carrageenin-induced paw oedema in rats.
Topics: Animals; Arecoline; Carbachol; Carrageenan; Cerebellum; Corpus Striatum; Edema; Female; Foot; Gallamine Triethiodide; Inflammation; Male; Oxotremorine; Pirenzepine; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine | 1991 |
Sialic acid residues as catalysts for M2-muscarinic agonist-receptor interactions.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cell Membrane; Kinetics; Male; Myocardium; Neuraminidase; Oxotremorine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Sialic Acids | 1990 |
Characterization of a muscarinic receptor controlling Cl- secretion in hen trachea.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bumetanide; Calcium Channels; Chickens; Chlorides; Dicyclomine; Female; In Vitro Techniques; Ion Channels; Kinetics; Mucous Membrane; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Pre- and postjunctional muscarinic receptors in canine bronchi.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bethanechol Compounds; Bronchi; Carbachol; Dogs; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
Selective inhibition of responses to carbachol and McN-A-343 in the rabbit vas deferens.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bis-Trimethylammonium Compounds; Carbachol; Cocaine; Electric Stimulation; In Vitro Techniques; Isoindoles; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pancuronium; Pirenzepine; Rabbits; Vas Deferens | 1990 |
Effects of pirenzepine and AF-DX 116 on ganglionic transmission in the cardiac sympathetic nerves of the dog: interaction of M1 and M2 receptors with nicotinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Blood Pressure; Dogs; Electric Stimulation; Female; Ganglia, Sympathetic; Heart Rate; Hexamethonium; Hexamethonium Compounds; Male; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Sympathetic Nervous System; Synaptic Transmission | 1991 |
Muscarinic regulation of cyclic AMP metabolism in rat neostriatal cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cells, Cultured; Corpus Striatum; Cyclic AMP; Embryo, Mammalian; Kinetics; N-Methylscopolamine; Neurons; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Cells, Cultured; Electric Conductivity; GTP-Binding Proteins; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Pertussis Toxin; Pirenzepine; Receptors, Muscarinic; Sodium; Virulence Factors, Bordetella | 1991 |
Muscarinic receptor is coupled with a cation channel through a GTP-binding protein in guinea-pig chromaffin cells.
Topics: Adrenal Medulla; Animals; Barium; Calcium; Dose-Response Relationship, Drug; Female; GTP-Binding Proteins; Guinea Pigs; Ion Channels; Male; Membrane Potentials; Muscarine; Oxotremorine; Pirenzepine; Receptors, Muscarinic; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Functional subtyping of muscarinic receptors on canine esophageal mucosa.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Amiloride; Animals; Atropine; Carbachol; Chlorides; Dogs; Electric Conductivity; Esophagus; Female; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Mucous Membrane; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Sodium | 1991 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihypertensive Agents; Aorta, Abdominal; Arecoline; Atropine; Diamines; Endothelium, Vascular; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Norepinephrine; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic | 1991 |
Internal Ca2+ mobilization by muscarinic stimulation increases secretion from adrenal chromaffin cells only in the presence of Ca2+ influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Atropine; Calcium; Catecholamines; Cats; Cattle; Cytosol; Gallopamil; Kinetics; Methacholine Chloride; Muscarine; Nicotine; Parasympatholytics; Pilocarpine; Pirenzepine; Receptors, Muscarinic | 1991 |
Different effects of muscarinic agonists in rat superior cervical ganglion and hippocampal slices.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Ganglia, Sympathetic; Hippocampus; In Vitro Techniques; Male; Oxotremorine; Parasympathomimetics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains | 1991 |
Presynaptic M2-muscarinic receptors on noradrenergic nerve endings and endothelium-derived M3 receptors in cat cerebral arteries.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Carbachol; Cats; Cerebral Arteries; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasodilation | 1991 |
Muscarinic autoreceptors of Torpedo electric organ are of the M1 subtype: evidence by radioligand binding using selective antagonists.
Topics: Animals; Diamines; Electric Organ; Muscarinic Antagonists; Myocardium; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Muscarinic; Torpedo | 1992 |
Analysis of preganglionic nerve evoked cholinergic contractions of the guinea pig bronchus.
Topics: Animals; Bronchoconstriction; Electric Stimulation; Electrophysiology; Ganglia, Parasympathetic; Guinea Pigs; Male; Parasympathetic Nervous System; Parasympatholytics; Pirenzepine; Time Factors; Vagus Nerve | 1991 |
Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes.
Topics: Animals; Binding, Competitive; Cells, Cultured; Colon; Dogs; Female; GTP-Binding Proteins; Male; Membranes; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Tritium | 1991 |
Pre- and postjunctional muscarinic receptor subtypes in dog airways.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1991 |
Muscarinic acetylcholine receptors are expressed and enriched in growth cone membranes isolated from fetal and neonatal rat forebrain: pharmacological demonstration and characterization.
Topics: Animals; Animals, Newborn; Atropine; Axons; Binding, Competitive; Cell Membrane; Nerve Tissue Proteins; Pirenzepine; Prosencephalon; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Acetylcholine receptors in dissociated nucleus basalis of Meynert neurons of the rat.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Membrane Potentials; Neurons; Nicotine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Substantia Innominata | 1991 |
Effects of anticholinergic drugs on rabbit efferent phrenic discharges.
Topics: Animals; Atropine; Electrophysiology; Female; Injections, Intraventricular; Male; Phrenic Nerve; Pirenzepine; Rabbits; Respiratory Center; Scopolamine; Vagotomy | 1991 |
Anti-muscarinic effect of alinidine on acetylcholine-induced vasodilation in isolated and perfused dog coronary arteries.
Topics: Acetylcholine; Animals; Carbachol; Clonidine; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Parasympatholytics; Piperidines; Pirenzepine; Vasodilation | 1991 |
In vivo probing of the brain cholinergic system in the aged rat. Effects of long-term treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Acetylcholine; Aging; Analysis of Variance; Animals; Atropine; Hippocampus; Male; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reference Values | 1991 |
Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay.
Topics: Acetylcholine; Administration, Topical; Animals; Atropine; Corpus Striatum; Dialysis; Male; Muscarine; Parasympatholytics; Physostigmine; Pirenzepine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Human erythrocyte as a model for investigating muscarinic agonists and antagonists.
Topics: Animals; Brain; Caudate Nucleus; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Models, Biological; Parasympatholytics; Parasympathomimetics; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1991 |
Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes.
Topics: Animals; Centrifugation; Cerebral Cortex; Cholic Acids; Digitonin; Gallamine Triethiodide; Heart; In Vitro Techniques; Lacrimal Apparatus; Membranes; Muscarinic Antagonists; Myocardium; Parasympatholytics; Piperidines; Pirenzepine; Rats; Structure-Activity Relationship | 1991 |
Characterization of muscarinic receptor subtype of rat eccrine sweat gland by autoradiography.
Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Eccrine Glands; Kinetics; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tritium | 1991 |
Muscarinic responses of gastric parietal cells.
Topics: Aminopyrine; Animals; Arachidonic Acids; Calcium; Carbachol; Glucose; Image Processing, Computer-Assisted; Ionomycin; N-Methylscopolamine; Parasympatholytics; Parietal Cells, Gastric; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1991 |
AF-DX 116, a cardioselective muscarinic antagonist in humans: pharmacodynamic and pharmacokinetic properties.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; Male; Parasympatholytics; Pirenzepine; Propranolol; Random Allocation; Receptors, Muscarinic; Reference Values; Salivation | 1991 |
Distribution and function of cholinergic receptors in the sheep detrusor muscle.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Parasympathetic; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Piperidines; Pirenzepine; Receptors, Muscarinic; Sheep; Tetraisopropylpyrophosphamide; Urinary Bladder | 1991 |
Activation of nigral M1 and M2 muscarinic receptors produces opposing effects on striatal 3,4-dihydroxyphenylacetic acid measured by in vivo voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Electrochemistry; Functional Laterality; Male; Muscarine; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stereotaxic Techniques; Substantia Nigra | 1991 |
Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Stem; Cerebral Cortex; CHO Cells; Cloning, Molecular; Corpus Striatum; Cricetinae; Kinetics; Myocardium; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Tritium | 1991 |
Muscarinic stimulation of adenylate cyclase activity of rat olfactory bulb. I. Analysis of agonist sensitivity.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Corpus Striatum; Drug Interactions; Male; Muscarinic Antagonists; Olfactory Bulb; Pilocarpine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sodium; Stimulation, Chemical | 1991 |
Biphasic dose-response curves to arecoline in rat atria-mediation by a single promiscuous receptor or two receptor subtypes?
Topics: Animals; Arecoline; Dose-Response Relationship, Drug; GTP-Binding Proteins; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Pertussis Toxin; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Virulence Factors, Bordetella | 1991 |
Mad honey poisoning in man and rat.
Topics: Aged; Animals; Atropine; Bradycardia; Diterpenes; Female; Honey; Humans; Hypotension; Male; Middle Aged; Parasympatholytics; Pirenzepine; Rats; Respiration; Turkey | 1991 |
Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebral Cortex; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Iodocyanopindolol; Ketanserin; Male; Middle Aged; Oxotremorine; Paroxetine; Pindolol; Piperidines; Pirenzepine; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
Differential affinities of AF-DX 116, atropine and pirenzepine for muscarinic receptors of guinea pig gastric fundus, atria and urinary bladder: might atropine distinguish among muscarinic receptor subtypes?
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Female; Gastric Fundus; Guinea Pigs; Heart Atria; Kinetics; Male; Muscarinic Antagonists; Myocardium; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Urinary Bladder | 1990 |
Predominant acetylcholine-induced vasoconstriction in isolated, perfused simian facial veins.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Diltiazem; Face; Female; In Vitro Techniques; Macaca; Male; Muscle, Smooth, Vascular; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Potassium Chloride; Quinazolines; Receptors, Muscarinic; Saponins; Vasoconstriction; Veins | 1990 |
N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Drug Interactions; Male; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1991 |
Phospholipase D activity and phosphatidylethanol formation in stimulated HeLa cells expressing the human m1 muscarinic acetylcholine receptor gene.
Topics: Cloning, Molecular; Enzyme Activation; Genetic Vectors; Glycerophospholipids; HeLa Cells; Humans; Kinetics; Myristic Acid; Myristic Acids; Oxotremorine; Parasympatholytics; Phosphatidic Acids; Phospholipase D; Pirenzepine; Plasmids; Quinuclidinyl Benzilate; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Reserpine-induced post-receptor reduction in muscarinic-mediated airway smooth muscle contraction.
Topics: Animals; Binding, Competitive; Bronchi; Humans; Lung; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Organ Specificity; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Reserpine; Trachea | 1991 |
The effects of AF-DX 116, a cardioselective muscarinic antagonist, on the negative inotropic action of acetylcholine.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Pirenzepine; Propranolol; Rabbits; Rats; Receptors, Muscarinic | 1991 |
Telenzepine inhibits electrically-stimulated, acetylcholine plus histamine-mediated acid secretion in the mouse isolated stomach by blockade of M1 muscarine receptors.
Topics: Acetylcholine; Alkaloids; Animals; Anti-Ulcer Agents; Electric Stimulation; Furans; Gastric Acid; Gastric Mucosa; Histamine; Mice; Muscarinic Antagonists; Naphthalenes; p-Methoxy-N-methylphenethylamine; Parasympatholytics; Piperidines; Pirenzepine; Stomach; Thiazepines; Vagus Nerve | 1991 |
Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Cats; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist.
Topics: Animals; Atropine; Calcium; Humans; Parasympathomimetics; Pirenzepine; Psychotropic Drugs; Pyrrolidinones; Tumor Cells, Cultured; Xenopus | 1991 |
Prejunctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype.
Topics: Animals; Diamines; Electric Stimulation; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Male; Parasympathetic Nervous System; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1991 |
Native Xenopus oocytes express two types of muscarinic receptors.
Topics: Animals; Atropine; Elapid Venoms; Female; Oligonucleotide Probes; Oligonucleotides, Antisense; Oocytes; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Xenopus laevis | 1991 |
Functional participation in M1 receptor subtype on chronotropic and dromotropic responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Atropine; Dogs; Electric Stimulation; Heart; Heart Conduction System; Heart Rate; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Vagus Nerve | 1991 |
Activation of the pharmacologically defined M3 muscarinic receptor depolarizes hippocampal pyramidal cells.
Topics: Animals; Carbachol; Evoked Potentials; Hippocampus; In Vitro Techniques; Kinetics; Parasympatholytics; Piperidines; Pirenzepine; Pyramidal Tracts; Rats; Receptors, Muscarinic | 1990 |
A presynaptic excitatory M1 muscarine receptor at postganglionic cardiac noradrenergic nerve fibres that is activated by endogenous acetylcholine.
Topics: Acetylcholine; Animals; Autonomic Fibers, Postganglionic; Carbon Radioisotopes; Electric Stimulation; Female; Heart; Male; Norepinephrine; Pirenzepine; Rabbits; Reaction Time; Receptors, Muscarinic; Sympathetic Nervous System; Synaptosomes; Vagus Nerve | 1990 |
Developmental changes in the muscarinic stimulation of canine Purkinje fibers.
Topics: Acetylcholine; Age Factors; Animals; Dogs; Female; GTP-Binding Proteins; Heart Conduction System; In Vitro Techniques; Male; Membrane Potentials; Oxotremorine; Pertussis Toxin; Pirenzepine; Purkinje Fibers; Receptors, Muscarinic; Virulence Factors, Bordetella | 1990 |
Ventral medulla sites of muscarinic receptor subtypes involved in cardiorespiratory control.
Topics: Animals; Carbon Dioxide; Cardiovascular Physiological Phenomena; Cardiovascular System; Cats; Chemoreceptor Cells; Female; Male; Medulla Oblongata; Parasympatholytics; Phrenic Nerve; Piperidines; Pirenzepine; Receptors, Muscarinic; Respiratory Physiological Phenomena; Respiratory System | 1990 |
Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle.
Topics: Bronchi; Humans; In Vitro Techniques; Ipratropium; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Pharmacological evidence for distinct muscarinic receptor subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea pig myometrium.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Cyclic AMP; Female; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Myometrium; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Type C Phospholipases; Uterine Contraction | 1990 |
Muscarinic M3 receptors are coupled to two signal transduction pathways in rat submandibular cells.
Topics: Animals; Atropine; Carbachol; Cyclic AMP; Parasympatholytics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Signal Transduction; Submandibular Gland | 1990 |
Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle.
Topics: Animals; Cattle; In Vitro Techniques; Inositol Phosphates; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Fibroblasts; Furans; Gene Amplification; Gene Expression; Molecular Sequence Data; Muscarinic Antagonists; Naphthalenes; Phosphatidylinositols; Piperidines; Pirenzepine; Plasmids; Polymerase Chain Reaction; Rats; Receptors, Muscarinic; Transfection | 1990 |
Chimeric m2/m3 muscarinic receptors: role of carboxyl terminal receptor domains in selectivity of ligand binding and coupling to phosphoinositide hydrolysis.
Topics: Animals; Cells, Cultured; Diamines; Hydrolysis; Ligands; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship | 1990 |
Effects of WEB 1881 FU, a novel nootropic, on cholinergic and adrenergic receptors in the rat brain: action on M1-muscarinic receptors.
Topics: Animals; Brain Chemistry; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Iodocyanopindolol; Kinetics; Male; Nicotine; Parasympatholytics; Pindolol; Pirenzepine; Prazosin; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Muscarinic; Thionucleotides; Yohimbine | 1990 |
Labeling of rat heart muscarinic receptors using the new M2 selective antagonist [3H]AF-DX 384.
Topics: Affinity Labels; Animals; Atropine; Binding, Competitive; Male; Muscarinic Antagonists; Myocardium; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1990 |
Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors.
Topics: Carbachol; Gastric Mucosa; Humans; In Vitro Techniques; N-Methylscopolamine; Parasympatholytics; Piperazines; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Evidence for a preferential involvement of M1 muscarinic receptors in representational memory.
Topics: Animals; Hippocampus; Male; Memory; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Reference Values | 1990 |
Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Choline; Kinetics; Male; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1990 |
Differential effects of the muscarinic M2 antagonists, AF-DX 116 and gallamine, on single neurons of rabbit sympathetic ganglia.
Topics: Action Potentials; Animals; Electrophysiology; Gallamine Triethiodide; Ganglia, Sympathetic; Membrane Potentials; Membranes; Methacholine Compounds; Neurons; Parasympatholytics; Pirenzepine; Rabbits | 1990 |
Pharmacological differentiation of presynaptic M1 muscarinic receptors modulating acetylcholine release from postsynaptic muscarinic receptors in guinea-pig ileum.
Topics: Acetylcholine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Synapses | 1990 |
The binding of [3H]4-diphenylacetoxy-N-methylpiperidine methiodide to longitudinal ileal smooth muscle muscarinic receptors.
Topics: Animals; Binding, Competitive; Diamines; Gallamine Triethiodide; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
Endogenous aspartate release in the rat hippocampus is inhibited by M2 'cardiac' muscarinic receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Calcium; Carbachol; Chromatography, High Pressure Liquid; Heart; Hippocampus; In Vitro Techniques; Male; Myocardium; Neuromuscular Depolarizing Agents; Oxotremorine; Pirenzepine; Potassium; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Synaptosomes | 1990 |
Characterization of presynaptic vascular muscarinic receptors inhibiting endogenous noradrenaline overflow in the portal vein of the freely moving rat.
Topics: Animals; Catecholamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrochemistry; Male; Muscle, Smooth, Vascular; Norepinephrine; Piperidines; Pirenzepine; Portal Vein; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Synapses | 1990 |
The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart.
Topics: Adenylyl Cyclase Inhibitors; Amitriptyline; Animals; Brain; Doxepin; Heart; Imipramine; In Vitro Techniques; Male; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Carbachol-induced potentiation and inhibition of acid secretion by guinea pig gastric gland.
Topics: Aminopyrine; Animals; Atropine; Binding, Competitive; Carbachol; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine; In Vitro Techniques; Male; N-Methylscopolamine; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Muscarinic suppression of the evoked N-wave by oxotremorine-M recorded in the guinea-pig olfactory cortex slice.
Topics: Action Potentials; Animals; Carbachol; Cerebral Cortex; Diamines; Electric Stimulation; Electroencephalography; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Olfactory Bulb; Oxotremorine; Parasympatholytics; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic | 1990 |
In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues.
Topics: Animals; Atropine; Calcium; Female; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Structure-Activity Relationship; Thiazepines; Tumor Cells, Cultured; Urinary Bladder; Vas Deferens | 1990 |
M1 and M2 muscarinic receptors mediate excitation and inhibition of guinea-pig intracardiac neurones in culture.
Topics: Action Potentials; Animals; Cells, Cultured; Ganglia; Guinea Pigs; Heart; Membrane Potentials; Muscarine; Neural Inhibition; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
An M3-like muscarinic autoreceptor regulates the in vivo release of acetylcholine in rat striatum.
Topics: Acetylcholine; Animals; Atropine; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Male; Neostigmine; Oxotremorine; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Time Factors | 1990 |
Effects of aging on nicotinic and muscarinic autoreceptor function in the rat brain: relationship to presynaptic cholinergic markers and binding sites.
Topics: Acetylcholine; Aging; Animals; Brain; Carbachol; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Hippocampus; Male; Muscarinic Antagonists; Nicotinic Antagonists; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Synapses; Thalamus | 1990 |
Post-training injection of the acetylcholine M2 receptor antagonist AF-DX 116 improves memory.
Topics: Animals; Dose-Response Relationship, Drug; Learning; Male; Memory; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Reference Values; Time Factors | 1990 |
Identification of three muscarinic receptor subtypes in rat lung using binding studies with selective antagonists.
Topics: Animals; Bronchi; Lung; Male; Muscarinic Antagonists; Myocardium; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Trachea | 1990 |
A cholinergic antagonist identifies a subclass of muscarinic receptors in isolated rat pancreatic acini.
Topics: Amylases; Animals; Atropine; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Activation of M2 muscarinic receptors causes an alteration of action potentials by modulation of Ca entry in isolated sympathetic neurons of rabbits.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Action Potentials; Animals; Calcium; Cells, Cultured; Ganglia, Sympathetic; Male; Muscarine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic | 1986 |
Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M1 type receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Injections, Spinal; Male; Mice; Parasympathomimetics; Pilocarpine; Pirenzepine; Receptors, Muscarinic; Spinal Cord; Stereotyped Behavior | 1987 |
Prostaglandin synthesis elicited by cholinergic stimuli is mediated by activation of M2 muscarinic receptors in rabbit heart.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Arecoline; Heart; Heart Rate; Hexamethonium Compounds; Indomethacin; Male; Myocardium; Phentolamine; Pirenzepine; Propranolol; Prostaglandins; Rabbits; Receptors, Muscarinic | 1988 |
Muscarinic receptor subtypes mediating myocardial blood flow redistribution.
Topics: Animals; Aorta; Coronary Circulation; Dogs; Female; Hemodynamics; In Vitro Techniques; Male; Methacholine Compounds; Pirenzepine; Rabbits; Receptors, Muscarinic | 1988 |
Vascular muscarinic receptors: pharmacological characterization in the bovine coronary artery.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Calcimycin; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Muscle Contraction; Muscle, Smooth, Vascular; Pirenzepine; Rabbits; Receptors, Muscarinic | 1988 |
Regulation of histamine release and synthesis in the brain by muscarinic receptors.
Topics: Animals; Brain; Carbachol; Histamine Release; Male; Oxotremorine; Pirenzepine; Potassium; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine | 1989 |
Modulation of synaptic transmission in autonomic ganglia mediated via the activation of postganglionic muscarinic M1 receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Ganglia, Autonomic; Ganglia, Sympathetic; In Vitro Techniques; Muscarine; Pirenzepine; Rabbits; Rats; Receptors, Muscarinic; Synapses; Synaptic Transmission | 1988 |
M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Blood Pressure; Glutamates; Heart Rate; Male; Medulla Oblongata; Microinjections; Physostigmine; Pirenzepine; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Reference Values | 1989 |
Rostral ventrolateral medulla muscarinic receptor involvement in central ventilatory chemosensitivity.
Topics: Animals; Atropine; Blood Pressure; Carbachol; Carbon Dioxide; Cats; Female; Male; Medulla Oblongata; Phrenic Nerve; Pirenzepine; Receptors, Muscarinic; Reference Values; Respiration; Vagotomy | 1989 |
Characterization of the muscarinic receptor subtype mediating contractions of the guinea-pig uterus.
Topics: Animals; Diamines; Edetic Acid; Female; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic; Uterine Contraction | 1989 |
Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.
Topics: Animals; Brain Stem; Corpus Striatum; Cyclic AMP; Diamines; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic | 1989 |
Human HT-29 colon carcinoma cells contain muscarinic M3 receptors coupled to phosphoinositide metabolism.
Topics: Carbachol; Carcinoma; Colonic Neoplasms; Gastric Mucosa; Humans; Inositol Phosphates; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Tumor Cells, Cultured | 1989 |
Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function.
Topics: Animals; Aspartic Acid; Cricetinae; Mutation; Phosphatidylinositols; Pirenzepine; Propylbenzilylcholine Mustard; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1989 |
Interaction acetylcholine-glutamate in rat hippocampus: involvement of two subtypes of M-2 muscarinic receptors.
Topics: Acetylcholine; Animals; Carbachol; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Oxotremorine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Synaptosomes | 1989 |
Muscarinic receptor subtypes involved in bethanechol-induced water intake in the rat.
Topics: Animals; Bethanechol Compounds; Drinking; Injections, Intraventricular; Pirenzepine; Rats; Receptors, Muscarinic | 1989 |
Quantitative autoradiographic localization of the M1 and M2 subtypes of muscarinic acetylcholine receptors in the monkey brain.
Topics: Animals; Autoradiography; Brain; In Vitro Techniques; Kinetics; Macaca; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic | 1989 |
An endogenous factor induces heterogeneity of binding sites of selective muscarinic receptor antagonists in rat heart.
Topics: Animals; Binding Sites; Binding, Competitive; Cytosol; Male; Membrane Proteins; Muscarinic Antagonists; Myocardium; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tissue Extracts; Tritium | 1989 |
Quantitative autoradiography of M2 muscarinic receptors in the rat brain identified by using a selective radioligand [3H]AF-DX 116.
Topics: Animals; Autoradiography; Brain; In Vitro Techniques; Male; Organ Specificity; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tritium | 1989 |
Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.
Topics: Animals; Cattle; Dexetimide; Diamines; Gallamine Triethiodide; Heart; In Vitro Techniques; Membrane Proteins; Muscle, Smooth; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Trachea | 1989 |
Muscarinic pharmacology of the spinal cord of the neonatal rat in vitro.
Topics: Action Potentials; Animals; Animals, Newborn; Atropine; In Vitro Techniques; Muscarine; Pirenzepine; Rats; Rats, Inbred Strains; Spinal Cord | 1989 |
Biphasic dose-response curve to muscarine on the rat superior cervical ganglion.
Topics: Animals; Dose-Response Relationship, Drug; Gallamine Triethiodide; Ganglia, Spinal; In Vitro Techniques; Muscarine; Pertussis Toxin; Pirenzepine; Rats; Virulence Factors, Bordetella | 1989 |
AF-DX 116 differentiates between prejunctional muscarine receptors located on noradrenergic and cholinergic nerves.
Topics: Acetylcholine; Animals; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Iris; Male; Muscle, Smooth; Myocardium; Norepinephrine; Parasympathetic Nervous System; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sympathetic Nervous System | 1989 |
Subtypes of muscarinic receptors in pancreatic exocrine secretion in anesthetized dog.
Topics: Animals; Atropine; Bethanechol Compounds; Dogs; Female; Kinetics; Male; Pancreas; Pancreatic Juice; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Reference Values | 1989 |
Differential effects of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism in freely moving rats.
Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Oxotremorine; Pirenzepine; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiophenes | 1989 |
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1.
Topics: Arecoline; Atropine; Carbachol; Cell Membrane; Humans; Neuroblastoma; Piperidines; Pirenzepine; Receptors, Muscarinic; Tumor Cells, Cultured | 1989 |
AF-DX 116 discriminates heart from gland M2-cholinoceptors in man.
Topics: Adult; Animals; Atropine; Blood Pressure; Cattle; Cell Membrane; Cerebral Cortex; Heart Rate; Humans; Kinetics; Male; Myocardium; N-Methylscopolamine; Organ Specificity; Pirenzepine; Propranolol; Receptors, Cholinergic; Reference Values; Saliva; Salivary Glands; Scopolamine Derivatives; Swine | 1989 |
Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Male; Membrane Potentials; Muscarine; Parasympatholytics; Pirenzepine; Rabbits; Rats; Receptors, Muscarinic; Time Factors | 1989 |
Characterization of [3H]AF-DX 116 binding sites in the rat brain: evidence for heterogeneity of muscarinic-M2 receptor sites.
Topics: Animals; Binding, Competitive; Brain; Kinetics; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1989 |
Quantitative autoradiographic distribution of [3H]AF-DX 116 muscarinic-M2 receptor binding sites in rat brain.
Topics: Animals; Autoradiography; Brain; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1989 |
Binding sites for [3H]AF-DX 116 and effect of AF-DX 116 on endogenous acetylcholine release from rat brain slices.
Topics: Acetylcholine; Animals; Brain; In Vitro Techniques; Male; Oxotremorine; Parasympathomimetics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1989 |
Direct labeling of rat M3-muscarinic receptors by [3H]4DAMP.
Topics: Adamantane; Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Ligands; N-Methylscopolamine; Pirenzepine; Proteins; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland | 1989 |
Presynaptic cholinergic mechanisms in the rat cerebellum: evidence for nicotinic, but not muscarinic autoreceptors.
Topics: Acetylcholine; Animals; Brain; Carbachol; Cerebellum; In Vitro Techniques; Kinetics; Ligands; Male; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Nicotinic | 1989 |
Coupling of subtypes of the muscarinic receptor to adenylate cyclase in the corpus striatum and heart.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; Corpus Striatum; Gallamine Triethiodide; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives | 1989 |
Muscarinic suppression of the M-current in the rat sympathetic ganglion is mediated by receptors of the M1-subtype.
Topics: Animals; Calcium; Gallamine Triethiodide; Ganglia, Spinal; Ganglia, Sympathetic; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Piperidines; Pirenzepine; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Selective agents for muscarinic receptors linked to phosphoinositide breakdown.
Topics: Adenylyl Cyclases; Animals; Brain; Heart; In Vitro Techniques; Male; Myocardium; Parasympatholytics; Parasympathomimetics; Phosphatidylinositols; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
Present status and future perspectives of muscarinic receptor antagonists.
Topics: Animals; Drug Therapy, Combination; Gastric Acid; Histamine H2 Antagonists; Humans; Parasympatholytics; Parietal Cells, Gastric; Peptic Ulcer; Pirenzepine | 1986 |
AF-DX 116, a cardioselective muscarinic antagonist.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Cats; Dimethylphenylpiperazinium Iodide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastric Acid; Gastric Emptying; Guinea Pigs; Heart; Heart Rate; Male; Muscarine; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Pirenzepine; Rats; Receptors, Muscarinic | 1987 |
Functional and direct binding studies using subtype selective muscarinic receptor antagonists.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Dicyclomine; Diphenylacetic Acids; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Myocardium; Phenethylamines; Phenylacetates; Pirenzepine; Receptors, Muscarinic | 1988 |
A novel muscarinic receptor antagonist AF-DX 116 differentially blocks slow inhibitory and slow excitatory postsynaptic potentials in the rabbit sympathetic ganglia.
Topics: Action Potentials; Animals; Bethanechol; Bethanechol Compounds; Evoked Potentials; Ganglia, Sympathetic; Male; Methacholine Chloride; Methacholine Compounds; Pirenzepine; Rabbits; Receptors, Muscarinic; Synapses | 1988 |
Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Esophagus; Imipramine; Kinetics; N-Methylscopolamine; Oxotremorine; Pepsinogens; Pirenzepine; Propranolol; Radioligand Assay; Rana catesbeiana; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
The muscarinic receptor subtype in mouse pancreatic B-cells.
Topics: Acetylcholine; Animals; Atropine; Calcium; Female; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Pirenzepine; Potassium; Receptors, Muscarinic; Rubidium Radioisotopes | 1988 |
Different antagonist binding properties of rat pancreatic and cardiac muscarinic receptors.
Topics: Animals; Binding, Competitive; GTP-Binding Proteins; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Type C Phospholipases | 1987 |
Contribution of M2 alpha and M2 beta muscarinic receptors to the action of cholinergic stimuli on prostaglandin synthesis and mechanical function in the isolated rabbit heart.
Topics: Acetylcholine; Animals; Arecoline; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Prostaglandins; Rabbits; Receptors, Muscarinic | 1988 |
The endogenous muscarinic acetylcholine receptor in Xenopus oocytes is of the M3 subtype.
Topics: Acetylcholine; Animals; Female; In Vitro Techniques; Membrane Potentials; Oocytes; Piperidines; Pirenzepine; Receptors, Cholinergic; Xenopus laevis | 1988 |
Characterization of muscarinic receptors in human pancreatic membranes.
Topics: Carbachol; Cell Membrane; Humans; Oxotremorine; Pancreas; Pilocarpine; Pirenzepine; Receptors, Muscarinic | 1988 |
Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Line; Cloning, Molecular; Gene Expression; Genetic Vectors; Humans; Inositol Phosphates; Kinetics; Molecular Sequence Data; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Restriction Mapping; Sequence Homology, Nucleic Acid; Transfection | 1988 |
AF-DX 116: a selective antagonist of the slow inhibitory postsynaptic potential and methacholine-induced hyperpolarization in superior cervical ganglion of the rabbit.
Topics: Animals; Ganglia, Sympathetic; In Vitro Techniques; Membrane Potentials; Methacholine Chloride; Methacholine Compounds; Pirenzepine; Rabbits; Receptors, Muscarinic; Synapses | 1988 |
M2 muscarinic receptors mediate pressor responses to cholinergic agonists in the ventrolateral medullary pressor area.
Topics: Animals; Blood Pressure; Decerebrate State; Dioxolanes; Dioxoles; Heart Rate; Male; Medulla Oblongata; Parasympathomimetics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stereotaxic Techniques | 1988 |
Different binding properties of muscarinic M2-receptor subtypes for agonists and antagonists in porcine gastric smooth muscle and mucosa.
Topics: Animals; Binding Sites; Carbachol; Ethylmaleimide; Gastric Mucosa; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic; Swine | 1988 |
The intact human neuroblastoma cell (SH-SY5Y) exhibits high-affinity [3H]pirenzepine binding associated with hydrolysis of phosphatidylinositols.
Topics: Atropine; Binding, Competitive; Humans; Hydrolysis; Kinetics; Neuroblastoma; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tumor Cells, Cultured | 1988 |
Binding of muscarine receptor antagonists to pig coronary smooth muscle.
Topics: Animals; Atropine; Carbachol; Coronary Vessels; Heart Atria; In Vitro Techniques; Muscle, Smooth, Vascular; Piperazines; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Swine; Tritium | 1988 |
The cloned murine M1 muscarinic receptor is associated with the hydrolysis of phosphatidylinositols in transfected murine B82 cells.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Cell Line; Cell Membrane; DNA, Recombinant; Fibroblasts; Guanylyl Imidodiphosphate; Hydrolysis; Mice; Muscarine; Nucleic Acid Hybridization; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Recombinant Proteins; Sequence Homology, Nucleic Acid; Transfection | 1988 |
Characterization of muscarinic receptors in guinea pig ileum longitudinal smooth muscle.
Topics: Animals; Binding, Competitive; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Myocardium; N-Methylscopolamine; Parasympatholytics; Phenoxybenzamine; Piperidines; Pirenzepine; Receptors, Muscarinic; Salivary Glands; Scopolamine Derivatives | 1988 |
Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA, Recombinant; Glycosylation; Molecular Sequence Data; Muscarine; Oocytes; Piperidines; Pirenzepine; Protein Conformation; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; RNA, Messenger; Sequence Homology, Nucleic Acid; Swine; Xenopus laevis | 1988 |
Receptor binding profiles of some selective muscarinic antagonists.
Topics: Animals; Cerebral Cortex; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Parotid Gland; Piperidines; Pirenzepine; Procyclidine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Urinary Bladder | 1988 |
Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacological evidence.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Animals; Blood Pressure; Hemicholinium 3; Medulla Oblongata; Microinjections; Nerve Endings; Parasympathetic Nervous System; Pirenzepine; Receptors, Muscarinic; Scopolamine; Sympathetic Nervous System | 1988 |
Direct binding studies on ileal and cardiac muscarinic receptors.
Topics: Animals; Gallamine Triethiodide; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Membranes; Muscle, Smooth; Myocardium; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Direct visualization of brain M2 muscarinic receptors using the selective antagonist [3H]AF-DX116.
Topics: Animals; Autoradiography; Brain; Male; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tissue Distribution | 1987 |
AF-DX 116 discriminates between muscarinic M2 receptors of the heart and vasculature.
Topics: Animals; Arteries; Atrial Function; Ear; Female; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Pirenzepine; Rabbits; Receptors, Muscarinic | 1987 |
Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116.
Topics: Animals; Cerebral Cortex; Female; Kinetics; Lung; Male; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic | 1987 |
Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors.
Topics: Animals; Dicyclomine; Ganglia, Sympathetic; Hippocampus; Male; Myocardium; Parasympathomimetics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Submandibular Gland | 1987 |
The M2 selective antagonist AF-DX 116 shows high affinity for muscarine receptors in bovine tracheal membranes.
Topics: Animals; Binding, Competitive; Cattle; Dexetimide; In Vitro Techniques; Membrane Proteins; Muscle, Smooth; Myocardium; Pirenzepine; Receptors, Muscarinic; Trachea | 1987 |
[3H]AF-DX 116 labels subsets of muscarinic cholinergic receptors in rat brain and heart.
Topics: Animals; Brain; Cell Membrane; Cerebral Cortex; Kinetics; Male; Myocardium; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tissue Distribution | 1987 |
Differential regulation of M2 muscarinic receptors by guanine nucleotides in rat cerebral cortical and cardiac membranes.
Topics: Animals; Cerebral Cortex; Guanine Nucleotides; Guanylyl Imidodiphosphate; Heart; In Vitro Techniques; Membranes; Pirenzepine; Rats; Receptors, Cholinergic; Receptors, Muscarinic | 1987 |
Muscarinic receptor heterogeneity in guinea pig intestinal smooth muscle: binding studies with AF-DX 116.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Myocardium; Pirenzepine; Receptors, Muscarinic; Salivary Glands | 1987 |
Competitive inhibition of phosphoinositide hydrolysis by the muscarinic receptor antagonist AF-DX 116 is of low affinity in mouse cerebral cortex.
Topics: Animals; Carbachol; Cerebral Cortex; In Vitro Techniques; Inositol Phosphates; Male; Mice; Mice, Inbred C57BL; Pirenzepine; Receptors, Muscarinic; Sugar Phosphates | 1987 |
Characterization of muscarinic receptors in salivary and lacrimal glands of the rat.
Topics: Animals; Atropine Derivatives; Dicyclomine; Exocrine Glands; In Vitro Techniques; Lacrimal Apparatus; Male; N-Methylscopolamine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Salivary Glands; Scopolamine Derivatives; Synaptosomes | 1987 |
Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Cell Membrane; Cerebellum; Cerebral Cortex; Kinetics; Lacrimal Apparatus; Male; Myocardium; N-Methylscopolamine; Organ Specificity; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland | 1986 |
Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist.
Topics: Animals; Atrial Function; Benzodiazepinones; Binding, Competitive; Cats; Clonidine; Dogs; Female; Guinea Pigs; Heart; Heart Atria; Heart Rate; Ileum; In Vitro Techniques; Kinetics; Male; Mice; Muscle, Smooth; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stomach; Sympatholytics; Urinary Bladder | 1986 |
Distribution of muscarinic receptor subtypes in rat brain as determined in binding studies with AF-DX 116 and pirenzepine.
Topics: Animals; Binding, Competitive; Brain; Kinetics; Male; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tissue Distribution | 1987 |
Muscarinic receptor subtypes mediating vasodilation and vasoconstriction in isolated, perfused simian coronary arteries.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Female; In Vitro Techniques; Macaca; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth, Vascular; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasoconstriction; Vasodilation | 1993 |
Muscarinic acetylcholine receptors on an identified motor neurone in the cockroach, Periplaneta americana.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Atropine; Dose-Response Relationship, Drug; Evoked Potentials; Ganglia, Invertebrate; In Vitro Techniques; Male; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Periplaneta; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine; Vertebrates | 1994 |
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Animals; Arecoline; Bethanechol; Carbachol; Diamines; Dose-Response Relationship, Drug; Furans; Ganglia, Parasympathetic; Ganglionectomy; Iris; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 1995 |
Cholinergic activation of Cl- secretion in rat colonic epithelia.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Binding, Competitive; Chlorides; Cholinergic Agonists; Cholinergic Antagonists; Colon; Dose-Response Relationship, Drug; Epithelium; Hexamethonium; In Vitro Techniques; Ion Transport; Male; Muscarinic Agonists; Parasympatholytics; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Wistar | 1995 |
Age-related changes in the density of muscarinic cholinergic M1 and M2 receptor subtypes in pyramidal neurons of the rat hippocampus.
Topics: Aging; Animals; Autoradiography; Hippocampus; Male; Parasympatholytics; Pirenzepine; Pyramidal Cells; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; Tritium | 1995 |
Pharmacological evidence for the existence of different subtypes of muscarinic acetylcholine receptors for phosphoinositide hydrolysis in neonatal versus adult rat atria.
Topics: Animals; Animals, Newborn; Carbachol; Depression, Chemical; Enzyme Inhibitors; Heart; Heart Atria; Hydrolysis; Muscarinic Agonists; Muscarinic Antagonists; Myocardial Contraction; Myocardium; Phosphatidylinositols; Pirenzepine; Rats; Receptors, Muscarinic; Type C Phospholipases | 1995 |
No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea.
Topics: Animals; Bronchoconstrictor Agents; Cattle; Dose-Response Relationship, Drug; Gallamine Triethiodide; Histamine; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicotinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Adrenergic, beta; Receptors, Muscarinic; Trachea | 1995 |
Functional expression of a cloned Drosophila muscarinic acetylcholine receptor in a stable Drosophila cell line.
Topics: Animals; Calcium; Cell Line; Cloning, Molecular; Drosophila melanogaster; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Fura-2; Gene Expression Regulation; Microscopy, Fluorescence; Molecular Weight; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1995 |
Otenzepad shows two populations of binding sites in human gastric smooth muscle.
Topics: Adult; Aged; Atropine; Binding, Competitive; Female; Gastric Mucosa; Humans; In Vitro Techniques; Kinetics; Ligands; Male; Middle Aged; Muscle, Smooth; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1995 |
Muscarinic cholinergic receptor subtypes in human detrusor muscle studied by labeled and nonlabeled pirenzepine, AFDX-116 and 4DAMP.
Topics: Aged; Cystectomy; Female; Humans; Male; Muscle, Smooth; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Urinary Bladder Neoplasms | 1995 |
Prejunctional M1 and postjunctional M3 muscarinic receptors in the circular muscle of the guinea-pig ileum.
Topics: Acetylcholine; Animals; Choline; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1995 |
Mode of antagonism of methoctramine, AF-DX 116 and hexahydrosiladifenidol in guinea-pig left atrium and ileum: comparison of Schild and resultant analysis.
Topics: Animals; Diamines; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Piperidines; Pirenzepine | 1995 |
Muscarinic depression of synaptic transmission and blockade of norepinephrine-induced long-lasting potentiation in the dentate gyrus.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Cyclic AMP; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Muscarine; Norepinephrine; Parasympatholytics; Pertussis Toxin; Piperidines; Pirenzepine; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synapses; Synaptic Transmission; Virulence Factors, Bordetella | 1993 |
Cholinergic responsiveness of neurons in the ventroposterior thalamus of the anesthetized rat.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Anesthesia, General; Animals; Carbachol; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Hypothalamus, Posterior; Iontophoresis; Male; Neurons; Parasympatholytics; Pirenzepine; Rats; Stereotaxic Techniques | 1993 |
The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle.
Topics: Animals; Carbachol; Ciliary Body; Dose-Response Relationship, Drug; In Vitro Techniques; Macaca mulatta; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Pirenzepine; Quinuclidines | 1994 |
Formation of inositol phosphates mediated by M3 muscarinic receptors in type-1 and type-2 astrocytes from neonatal rat cerebral cortex.
Topics: Animals; Animals, Newborn; Astrocytes; Atropine; Carbachol; Cells, Cultured; Cerebral Cortex; Inositol Phosphates; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Tubocurarine | 1994 |
Postoperative analgesia from intrathecal neostigmine in sheep.
Topics: Analgesia, Epidural; Animals; Female; Neostigmine; Pain Measurement; Pain, Postoperative; Pirenzepine; Receptors, Muscarinic; Sheep | 1995 |
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Diamines; Dose-Response Relationship, Drug; Furans; GTP-Binding Proteins; In Vitro Techniques; Iris; Male; Microinjections; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pertussis Toxin; Phentolamine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Virulence Factors, Bordetella | 1995 |
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity; Diamines; Disease Models, Animal; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart; Histamine; Hypersensitivity; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth; Neuromuscular Junction; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1995 |
[Binding of the M2-selective antagonist AF-DX 116 with frog myocardial muscarinic receptors].
Topics: Animals; Heart Ventricles; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Pirenzepine; Protein Binding; Radioligand Assay; Rana temporaria; Receptors, Muscarinic | 1995 |
Prejunctional muscarinic autoreceptors on horse airway cholinergic nerves.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Fibers; Electric Stimulation; Horses; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1995 |
Muscarinic inhibition of cardiac norepinephrine and neuropeptide Y release during ischemia and reperfusion.
Topics: Animals; Atropine; Carbachol; Electric Stimulation; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Neuropeptide Y; Norepinephrine; Oxotremorine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1994 |
Muscarinic receptors in rat uterus.
Topics: Alkaloids; Animals; Atropine; Binding, Competitive; Computer Simulation; Female; Furans; In Vitro Techniques; Ligands; Muscarinic Antagonists; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Uterus | 1994 |
Muscarinic cholinergic receptors in the hippocampus of aged rats: influence of choline alphoscerate treatment.
Topics: Aging; Animals; Autoradiography; Glycerylphosphorylcholine; Hippocampus; Male; Osmolar Concentration; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Tissue Distribution | 1994 |
Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle.
Topics: Adenylate Cyclase Toxin; Animals; Calcium; Cholera Toxin; GTP-Binding Proteins; Guinea Pigs; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pertussis Toxin; Pirenzepine; Potassium Channel Blockers; Potassium Channels; Receptors, Adrenergic, beta; Receptors, Muscarinic; Trachea; Virulence Factors, Bordetella | 1995 |
Two populations of muscarinic binding sites in the chick heart distinguished by affinities for ligands and selective inactivation.
Topics: Alcuronium; Animals; Chickens; Choline; Cholinergic Agents; Diamines; Female; In Vitro Techniques; Ligands; Male; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives | 1994 |
Muscarinic receptors in vagal routes to the biliary system in dogs.
Topics: Animals; Atropine; Biliary Tract; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Gallbladder; Pirenzepine; Receptors, Muscarinic; Sphincter of Oddi; Vagus Nerve | 1994 |
Nicotinic and muscarinic acetylcholine responses in differentiated PC12 cells.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Differentiation; Cell Membrane Permeability; Egtazic Acid; Hexamethonium; Hexamethonium Compounds; Membrane Potentials; Muscarine; Nerve Growth Factors; Nicotine; Nystatin; Parasympatholytics; PC12 Cells; Pirenzepine; Potassium; Receptors, Muscarinic; Receptors, Nicotinic; Tubocurarine | 1994 |
A physiologically-evoked M1-muscarinic depolarization in guinea-pig inferior mesenteric ganglion neurons.
Topics: Action Potentials; Animals; Atropine; Carbachol; Colon; Female; Ganglia, Sympathetic; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Male; Mechanoreceptors; Pirenzepine; Receptors, Muscarinic; Stress, Mechanical | 1994 |
Muscarinic receptor M1 and M2 subtypes in the human eye: QNB, pirenzipine, oxotremorine, and AFDX-116 in vitro autoradiography.
Topics: Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Autoradiography; Ciliary Body; Eye; Female; Humans; Iris; Male; Middle Aged; Oxotremorine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Retina | 1994 |
Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists.
Topics: Accommodation, Ocular; Animals; Aqueous Humor; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Pupil; Quinuclidines | 1994 |
Spinal cholinergic alpha-2 adrenergic interactions in analgesia and hemodynamic control: role of muscarinic receptor subtypes and nitric oxide.
Topics: Analgesia; Animals; Clonidine; Female; Hemodynamics; Neostigmine; Nitric Oxide; Pirenzepine; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Sheep; Spinal Cord | 1994 |
Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Cyclic AMP; Guanosine Triphosphate; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Signal Transduction; Virulence Factors, Bordetella | 1994 |
Facilitatory but nonessential role of the muscarinic cholinergic system in the generation of long-term potentiation of population spikes in the dentate gyrus in vivo.
Topics: Animals; Evoked Potentials; Hippocampus; Injections, Intraventricular; Long-Term Potentiation; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine | 1994 |
[Experimental techniques for developing new drugs acting on dementia (3)--Experimental methods on the long-term potentiation].
Topics: Animals; Cholinergic Agents; Dementia; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Pirenzepine; Rats | 1994 |
[Inhibitory effect of 6 beta-acetoxy nortropane on respiration].
Topics: Animals; Dogs; Female; Male; Muscarinic Agonists; Nortropanes; Parasympatholytics; Pirenzepine; Rabbits; Receptors, Muscarinic; Respiration; Respiratory Center; Tidal Volume | 1994 |
Cholinergic dilatation and constriction of feline cerebral blood vessels are mediated by stimulation of phosphoinositide metabolism via two different muscarinic receptor subtypes.
Topics: Animals; Carbachol; Cats; Cerebral Arteries; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Inositol Phosphates; Muscarinic Antagonists; Muscle, Smooth, Vascular; Parasympatholytics; Phosphatidylinositols; Pia Mater; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasoconstriction; Vasodilation | 1994 |
Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Heart Atria; Ileum; Lung; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Pirenzepine; Pulmonary Artery; Rabbits; Receptors, Muscarinic | 1994 |
Diabetes-induced alterations in the properties of muscarinic cholinergic receptors in rat vas deferens.
Topics: Animals; Atropine; Binding, Competitive; Diabetes Mellitus, Experimental; Diamines; Insulin; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Up-Regulation; Vas Deferens | 1994 |
Retrotrapezoid nucleus muscarinic receptor subtypes localized by autoradiography.
Topics: Adamantane; Animals; Autoradiography; Binding, Competitive; Cats; Female; In Vitro Techniques; Male; Medulla Oblongata; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tissue Distribution | 1994 |
Release of bombesin-like immunoreactivity from synaptosomal membranes isolated from the rat ileum.
Topics: Animals; Atropine; Bombesin; Calcium; Carbachol; Cell Fractionation; Centrifugation, Density Gradient; Ileum; Male; Microscopy, Electron; Pirenzepine; Potassium Chloride; Radioimmunoassay; Rats; Rats, Wistar; Synaptosomes | 1994 |
Bidirectional modulation of long-term potentiation by carbachol via M1 and M2 muscarinic receptors in guinea pig hippocampal mossy fiber-CA3 synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Infusions, Parenteral; Male; Nerve Fibers; Neurons; Parasympatholytics; Pirenzepine; Pyramidal Tracts; Receptors, Muscarinic; Synapses | 1993 |
Central muscarinic M2 cholinoceptors involved in cholinergic hypertension.
Topics: Animals; Blood Pressure; Diamines; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Muscarinic Antagonists; Oxotremorine; Physostigmine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1993 |
Characterization of the muscarinic receptors in the mesenteric vascular bed of spontaneously hypertensive rats.
Topics: Animals; Atropine; Benzodiazepinones; Endothelium, Vascular; Hypertension; Male; Mesenteric Artery, Superior; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Muscarinic; Vasodilation | 1993 |
Pharmacological characterization of muscarinic cholinergic receptors in cat pons and cortex. Preliminary study.
Topics: Animals; Atropine; Binding, Competitive; Cats; Cerebral Cortex; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Pons; Receptors, Muscarinic | 1994 |
In vivo characterization of vasodilating muscarinic-receptor subtypes in humans.
Topics: Acetylcholine; Adult; Atropine; Clinical Protocols; Forearm; Humans; Male; Methacholine Chloride; Pirenzepine; Receptors, Muscarinic; Vasodilation | 1994 |
Pharmacological characterization of muscarinic receptors in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Kinetics; Muscarine; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1993 |
Facilitation of memory storage by the acetylcholine M2 muscarinic receptor antagonist AF-DX 116.
Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Brain; Drug Synergism; Male; Memory; Mice; Neostigmine; Parasympatholytics; Physostigmine; Pirenzepine; Receptors, Muscarinic | 1993 |
Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist.
Topics: Animals; Binding Sites; Dibenzazepines; Guinea Pigs; Heart; Hemodynamics; Male; Muscarinic Antagonists; Muscle, Smooth; Myocardium; Parasympatholytics; Pirenzepine; Pyridines; Rabbits; Rats; Rats, Wistar; Receptors, Muscarinic | 1993 |
Characterization of muscarinic receptors on guinea pig gallbladder smooth muscle.
Topics: Animals; Autoradiography; Carbachol; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tetrodotoxin | 1993 |
Agonist-induced down-regulation and antagonist-induced up-regulation of m2- and m3-muscarinic acetylcholine receptor mRNA and protein in cultured cerebellar granule cells.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Cerebellum; Down-Regulation; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; RNA, Messenger; Up-Regulation | 1993 |
[A study on the affinities of various muscarinic antagonists to the human detrusor muscle].
Topics: Adamantane; Aged; Binding, Competitive; Female; Humans; Male; Middle Aged; Muscle, Smooth; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Urinary Bladder | 1993 |
Binding of the muscarine receptor antagonist heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide at cholinoceptor sites.
Topics: Animals; Binding, Competitive; Bis-Trimethylammonium Compounds; Cerebral Cortex; Female; In Vitro Techniques; Isoindoles; Kinetics; Lung; Male; Muscarinic Antagonists; Myocardium; Nicotine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Cholinergic | 1993 |
Age-related changes in pulmonary muscarinic receptor binding properties.
Topics: Aging; Animals; Binding, Competitive; Guinea Pigs; Lung; Male; Muscarine; Parasympathomimetics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1993 |
Characterization of muscarinic receptors in cultured human iris sphincter and ciliary smooth muscle cells.
Topics: Binding, Competitive; Cells, Cultured; Ciliary Body; Humans; Iris; Muscle, Smooth; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1993 |
Enhancement of glycine release from human brain cortex synaptosomes by acetylcholine acting at M4 muscarinic receptors.
Topics: Acetylcholine; Alkaloids; Cerebral Cortex; Cholinergic Fibers; Drug Synergism; Female; Furans; Glycine; Humans; Kinetics; Male; Muscarinic Antagonists; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Potassium Chloride; Receptors, Muscarinic; Stimulation, Chemical; Synaptic Transmission; Synaptosomes; Tritium | 1993 |
Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum.
Topics: Animals; Cyclic AMP; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Second Messenger Systems | 1993 |
Synthesis and muscarinic receptor binding profiles of antagonist benzotriazole derivatives.
Topics: Animals; Chromatography, Thin Layer; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Triazoles | 1993 |
Synthesis and structure-activity relationship of some 5-[[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H- benzo[b,e][1,4]diazepin-11-ones as M2-selective antimuscarinics.
Topics: Animals; Benzodiazepinones; Brain; Mice; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1993 |
Autoradiographic mapping of M3 muscarinic receptors in the rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Male; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Tritium | 1993 |
Differences between rat dorsal and ventral hippocampus in muscarinic receptor agonist binding and interaction with phospholipase C.
Topics: Alkaloids; Animals; Carbachol; Furans; Guanylyl Imidodiphosphate; Hippocampus; Male; Membranes; Mitochondria; N-Methylscopolamine; Naphthalenes; Oxotremorine; Parasympatholytics; Parasympathomimetics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Synaptosomes; Type C Phospholipases | 1993 |
Differential effects of antimuscarinic agents on intestinal motility in the conscious dog.
Topics: Animals; Atropine; Dogs; Female; Gastrointestinal Motility; Heart Rate; Male; Parasympatholytics; Piperidines; Pirenzepine; Pupil; Receptors, Muscarinic | 1993 |
Functional characterization of muscarinic receptors in murine airways.
Topics: Administration, Inhalation; Airway Resistance; Animals; Atropine; Bronchi; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Lung Compliance; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1993 |
Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; Humans; Inositol Phosphates; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Transfection; Tritium | 1995 |
Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon.
Topics: Alkaloids; Atropine; Carbachol; Carcinoma; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Furans; Humans; In Vitro Techniques; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Pirenzepine | 1995 |
Endogenous nitric oxide signalling system and the cardiac muscarinic acetylcholine receptor-inotropic response.
Topics: Analysis of Variance; Animals; Atropine; Binding Sites; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heart Atria; Male; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase; Parasympatholytics; Phosphatidylinositols; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases | 1995 |
Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus.
Topics: Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Esophagus; Gastric Fundus; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serotonin; Trachea; Virulence Factors, Bordetella | 1996 |
1,2,5-Thiadiazole derivatives of arecoline stimulate M1 receptors coupled to phosphoinositide turnover.
Topics: Animals; Arecoline; Dose-Response Relationship, Drug; Hippocampus; Male; Muscarinic Agonists; Muscarinic Antagonists; Parasympatholytics; Phosphatidylinositols; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiadiazoles | 1995 |
Effects of selective muscarinic antagonists, pirenzepine and AF-DX 116, on passive avoidance tasks in mice.
Topics: Animals; Atropine; Avoidance Learning; Male; Mice; Muscarinic Antagonists; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic | 1996 |
Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae.
Topics: Animals; Artemia; Atropine; Chlorpyrifos; Cholinergic Antagonists; Cholinesterase Reactivators; Cysts; Hexamethonium; Insecticides; Larva; Methyl Parathion; Parasympatholytics; Parathion; Pirenzepine; Poisoning; Pralidoxime Compounds; Species Specificity; Structure-Activity Relationship | 1996 |
In vivo binding, pharmacokinetics and metabolism of the selective M2 muscarinic antagonists [3H]AF-DX 116 and [3H]AF-DX 384 in the anesthetized rat.
Topics: Anesthesia; Animals; Brain; Chromatography, Thin Layer; Half-Life; Male; Muscarinic Antagonists; Parasympatholytics; Pirenzepine; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1996 |
Cardiopulmonary actions of muscarinic receptor subtypes in the newborn dog.
Topics: Airway Resistance; Analysis of Variance; Animals; Animals, Newborn; Bronchoconstriction; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pirenzepine; Respiratory Mechanics; Vagus Nerve | 1996 |
M2 muscarinic receptor inhibition of agonist-induced cyclic adenosine monophosphate accumulation and relaxation in the guinea pig ileum.
Topics: Animals; Cyclic AMP; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscle Relaxation; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic | 1997 |
Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Animals; Antibodies, Blocking; Atropine; Carbachol; Carbamates; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin G; Isoproterenol; Muscarinic Antagonists; Parasympatholytics; Parotid Gland; Phenylcarbamates; Phosphatidylinositols; Piperidines; Pirenzepine; Protease Inhibitors; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Sjogren's Syndrome | 1996 |
Involvement of M2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices.
Topics: Animals; Atropine; Carbachol; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Receptors, Muscarinic; Synapses | 1997 |
Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation.
Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atropine; Cell Membrane; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanylyl Imidodiphosphate; Heart Ventricles; Isoproterenol; Male; Muscarinic Antagonists; Pertussis Toxin; Pirenzepine; Propanolamines; Rabbits; Receptor, Muscarinic M2; Receptors, Adrenergic, beta; Receptors, Muscarinic; Virulence Factors, Bordetella | 1997 |
Modulation of the pressor response elicited by carbachol and electrical stimulation of the amygdala by muscarinic antagonists in conscious rats.
Topics: Amygdala; Analysis of Variance; Animals; Blood Pressure; Carbachol; Electric Stimulation; Female; Heart Rate; Injections, Intraventricular; Microinjections; Muscarinic Agonists; Muscarinic Antagonists; Parasympatholytics; Pirenzepine; Rats; Rats, Sprague-Dawley | 1997 |
Expression of muscarinic receptor subtypes in rat gastric smooth muscle: effect of M3 selective antagonist on gastric motility and emptying.
Topics: Animals; Atropine; Butylscopolammonium Bromide; Dioxoles; Gastric Emptying; Gastrointestinal Motility; Glucagon; Male; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Pirenzepine; Polymerase Chain Reaction; Rats; Receptors, Muscarinic; Stomach | 1997 |
Muscarinic control of phase III contractions and motilin release in dogs.
Topics: Animals; Cell Separation; Dogs; Duodenum; Female; Infusions, Intravenous; Intestinal Mucosa; Male; Motilin; Muscarinic Antagonists; Piperidines; Pirenzepine; Stomach | 1997 |
Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs.
Topics: Acetylcholine; Animals; Bronchoconstriction; Diabetes Mellitus, Experimental; Insulin; Insulin-Like Growth Factor I; Lung; Male; Neural Inhibition; Pilocarpine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Muscarinic; Streptozocin; Vagus Nerve | 1997 |
Exocytotic release from neuronal cell bodies, dendrites and nerve terminals in sympathetic ganglia of the rat, and its differential regulation.
Topics: Animals; Atropine; Carbachol; Cell Membrane; Dendrites; Exocytosis; Ganglia, Sympathetic; Male; Membrane Potentials; Nerve Endings; Neurons; Nicotine; Oxotremorine; Parasympatholytics; Pirenzepine; Potassium; Rats; Rats, Wistar; Receptors, Muscarinic; Regression Analysis; Synapses | 1997 |
New 5-aminoacyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones with antiarrhythmic activity.
Topics: Animals; Anti-Arrhythmia Agents; Benzodiazepines; Bronchi; Cats; Cholinergic Antagonists; Dogs; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Organ Specificity; Parasympatholytics; Pirenzepine; Pupil; Rats; Receptors, Muscarinic; Salivation; Urinary Bladder | 1997 |
Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon.
Topics: Animals; Colforsin; Colon; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella | 1998 |
Two opposite signal transducing mechanisms regulate a G-protein-coupled guanylyl cyclase.
Topics: Animals; Carbachol; Cattle; Cell Membrane; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanylate Cyclase; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Trachea; Virulence Factors, Bordetella | 1998 |
Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists.
Topics: Animals; Bradycardia; Cerebral Cortex; Dibenzazepines; Dogs; Heart; Male; Mice; Muscarinic Antagonists; Parasympatholytics; Phenylacetates; Pirenzepine; Pyridines; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Salivation; Structure-Activity Relationship; Submandibular Gland; Tremor | 1998 |
Synthesis, antimuscarinic activity and quantitative structure-activity relationship (QSAR) of tropinyl and piperidinyl esters.
Topics: Animals; Esters; In Vitro Techniques; Kinetics; Male; Models, Molecular; Muscarinic Antagonists; Piperidines; Pirenzepine; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Tropanes | 1998 |
M2 and M3 muscarinic receptors couple, respectively, with activation of nonselective cationic channels and potassium channels in intestinal smooth muscle cells.
Topics: Animals; Atropine; Calcium; Carbachol; Guinea Pigs; Male; Muscarinic Agonists; Muscle, Smooth; Piperidines; Pirenzepine; Potassium Channels; Receptors, Muscarinic | 1998 |
Muscarinic M1 receptor activation reduces maximum upstroke velocity of action potential in mouse right atria.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Action Potentials; Animals; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Mice; Microelectrodes; Muscarinic Agonists; Oxotremorine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1998 |
AF-DX 116, a presynaptic muscarinic receptor antagonist, potentiates the effects of glucose and reverses the effects of insulin on memory.
Topics: Acetylcholine; Animals; Glucose; Insulin; Male; Memory; Mice; Muscarinic Antagonists; Pirenzepine | 1998 |
Effects of M1 and M2 receptor agonists and blockers on dog respiration.
Topics: Animals; Blood Gas Analysis; Dogs; Female; Male; Muscarinic Agonists; Muscarinic Antagonists; Nortropanes; Pilocarpine; Pirenzepine; Respiration; Scopolamine | 1996 |
Muscarinic M2 receptor-mediated contraction in the guinea pig Taenia caeci: possible involvement of protein kinase C.
Topics: Animals; Cecum; Colforsin; Diphenylacetic Acids; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Kinetics; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Piperidines; Pirenzepine; Protein Kinase C; Receptor, Muscarinic M2; Receptors, Muscarinic; Second Messenger Systems | 1998 |
Synaptic inhibitory effects of edrophonium on sympathetic ganglionic transmission.
Topics: Acetylcholinesterase; Action Potentials; Animals; Axons; Cholinesterase Inhibitors; Edrophonium; Evoked Potentials; Muscarinic Antagonists; Neostigmine; Nerve Fibers; Parasympatholytics; Parasympathomimetics; Pirenzepine; Potassium; Presynaptic Terminals; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Synapses; Synaptic Transmission; Tritium | 1998 |
Effects of a cardioselective M2 receptor antagonist, AF-DX 116, on ventricular arrhythmias in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Female; Heart Rate; Male; Parasympatholytics; Pirenzepine; Tachycardia, Ventricular | 1997 |
3-Alpha-chloro-imperialine, a potent blocker of cholinergic presynaptic modulation of glutamatergic afferents in the rat neostriatum.
Topics: 4-Aminopyridine; Afferent Pathways; Animals; Atropine; Bicuculline; Carbachol; Cevanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gallamine Triethiodide; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Pirenzepine; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic; Synapses | 1998 |
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.
Topics: Animals; Colforsin; Diphenylacetic Acids; Guinea Pigs; Histamine; Ileum; Isoproterenol; Muscle Relaxation; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea; Virulence Factors, Bordetella | 1999 |
Pharmacologic study of muscarinic receptor subtypes and arteriolar dilations: a comparison of conducted and local responses.
Topics: Animals; Arterioles; Cheek; Cricetinae; Dose-Response Relationship, Drug; Microcirculation; Mouth Mucosa; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptors, Muscarinic; Reference Values; Scopolamine; Vasodilation | 1999 |
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
Topics: Animals; Colon; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Models, Biological; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella | 1999 |
Cholinergic modulation of neostriatal output: a functional antagonism between different types of muscarinic receptors.
Topics: Acetylcholine; Animals; Cadmium Chloride; Cesium; Chlorides; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Physostigmine; Pirenzepine; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Tetrodotoxin | 1999 |
Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay.
Topics: Algorithms; Animals; Antibodies; Cell Membrane; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Oxotremorine; Pirenzepine; Precipitin Tests; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic | 1999 |
Comparison of anti-M2-muscarinic effect of AF-DX 116 on atrioventricular nodal conduction with those of pirenzepine and atropine as antibradyarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Atropine; Cardiac Surgical Procedures; Dogs; Female; In Vitro Techniques; Male; Parasympatholytics; Perfusion; Pirenzepine | 1999 |
Cholinergic modulation of non-adrenergic, non-cholinergic relaxation in isolated, small coronary arteries from lambs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholinesterase; Adrenergic alpha-Antagonists; Animals; Capsaicin; Choline O-Acetyltransferase; Coronary Vessels; Electric Stimulation; In Vitro Techniques; Microcirculation; Myography; Norepinephrine; Phentolamine; Physostigmine; Pirenzepine; Propranolol; Sheep; Suramin; Vasoconstrictor Agents; Vasodilation | 1999 |
Otenzepad. AFDX 116.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drugs, Investigational; Humans; Male; Muscarinic Antagonists; Pirenzepine; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic | 1999 |
M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro.
Topics: Adenosine; Animals; Carbachol; Heart Rate; In Vitro Techniques; Male; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic | 2000 |
Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum.
Topics: Adenosine Triphosphate; Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Tetrodotoxin; Virulence Factors, Bordetella | 2000 |
Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation.
Topics: Acetylcholine; Animals; Atropine; Carotid Body; Cats; Gallamine Triethiodide; Hypoxia; In Vitro Techniques; Mecamylamine; Parasympatholytics; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic | 2000 |
Muscarinic control of histamine release from airways. Inhibitory M1-receptors in human bronchi but absence in rat trachea.
Topics: Acetylcholine; Animals; Bronchi; Calcimycin; Clozapine; Female; Histamine Release; Humans; Ionophores; Male; Mast Cells; Muscarinic Antagonists; Organ Culture Techniques; Oxotremorine; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Species Specificity; Trachea | 2000 |
Secretion and gene expression of secretory leukocyte protease inhibitor by human airway submucosal glands.
Topics: Adult; Aged; Aged, 80 and over; Atropine; Bronchi; Dexamethasone; Dose-Response Relationship, Drug; Exocrine Glands; Female; Gene Expression; Glucocorticoids; Humans; Leukocyte Elastase; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Proteinase Inhibitory Proteins, Secretory; Proteins; Respiratory Mucosa; RNA, Messenger; Secretory Leukocyte Peptidase Inhibitor; Trachea | 2001 |
Modulation by muscarinic receptor antagonists on negative chronotropic effects of tetrandrine.
Topics: Action Potentials; Alkaloids; Animals; Anti-Arrhythmia Agents; Atropine; Benzylisoquinolines; Calcium Channels; Depression, Chemical; Guinea Pigs; Heart Rate; Male; Muscarinic Antagonists; Myocardial Contraction; Pirenzepine; Rabbits; Rats; Sinoatrial Node | 1999 |
Mechanisms of acetylcholine-induced vasorelaxation in high K+-stimulated rabbit renal arteries.
Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Channel Blockers; Cations, Monovalent; Endothelium, Vascular; Gadolinium; Imidazoles; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Parasympatholytics; Piperidines; Pirenzepine; Potassium; Rabbits; Renal Artery; Tropicamide; Vasoconstriction; Vasodilation | 2001 |
The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria.
Topics: Acetylcholine; Allosteric Regulation; Animals; Atropine; Carbachol; Cardiotonic Agents; Dexetimide; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Nicotinic Antagonists; Parasympatholytics; Phthalimides; Pirenzepine; Quaternary Ammonium Compounds; Radioligand Assay; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Anguilla; Animals; Arginine; Atropine; Detergents; Enzyme Inhibitors; Female; Free Radical Scavengers; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Molsidomine; Muscarinic Antagonists; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Octoxynol; omega-N-Methylarginine; Ornithine; Oxadiazoles; Parasympatholytics; Pirenzepine; Quinoxalines; Superoxide Dismutase | 2001 |
Blood pressure and heart rate are increased by AF-DX 116, a selective M2 antagonist, in autonomic imbalanced and hypotensive rats caused by repeated cold stress.
Topics: Animals; Atropine; Blood Pressure; Cold Temperature; Heart Rate; Hypotension; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Stress, Physiological | 2001 |
M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse.
Topics: Acetylcholine; Animals; Male; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Pirenzepine; Prefrontal Cortex; Receptor, Muscarinic M2; Receptors, Muscarinic; Scopolamine | 2001 |
Coupling of M(2) muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells.
Topics: Animals; Atropine; Cells, Cultured; Colon; Dogs; Female; Gene Expression Regulation, Enzymologic; Genistein; Male; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Pyrazoles; Pyrimidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; src-Family Kinases; Teprotide | 2002 |
Beneficial effect of muscarinic-2 antagonist on dilated cardiomyopathy induced by autoimmune mechanism against muscarinic-2 receptor.
Topics: Animals; Anti-Arrhythmia Agents; Autoimmune Diseases; Blood Pressure; Body Weight; Cardiomyopathy, Dilated; Heart Rate; Injections, Subcutaneous; Muscarinic Antagonists; Myocardium; Peptides; Pirenzepine; Rabbits; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Prevention of experimental autoimmune cardiomyopathy in rabbits by receptor blockers.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Autoimmune Diseases; Bisoprolol; Cardiomyopathies; Disease Models, Animal; Muscarinic Antagonists; Pirenzepine; Rabbits; Receptors, Adrenergic, beta-1; Receptors, Muscarinic | 2001 |
Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility.
Topics: Animals; Anti-Arrhythmia Agents; Atropine; Carbachol; Cardiovascular Agents; Cholinesterase Inhibitors; Drug Interactions; Gallbladder; Indomethacin; Mice; Mice, Knockout; Muscarinic Antagonists; Muscle Contraction; Neostigmine; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic | 2002 |
[The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction].
Topics: Animals; Atropine; Brain; Female; Muscarine; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder; Urination | 2002 |
Prefrontal cortex acetylcholine release, EEG slow waves, and spindles are modulated by M2 autoreceptors in C57BL/6J mouse.
Topics: Acetylcholine; Animals; Autoreceptors; Electroencephalography; Isotonic Solutions; Male; Mice; Mice, Inbred C57BL; Microdialysis; Parasympatholytics; Pirenzepine; Prefrontal Cortex; Receptor, Muscarinic M2; Receptors, Muscarinic; Ringer's Solution | 2002 |
Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors.
Topics: Animals; Atropine; Central Nervous System; Cholinesterase Inhibitors; Cholinesterases; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Neurons; Patch-Clamp Techniques; Piperidines; Pirenzepine; Pyramidal Cells; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Receptors, Nicotinic; Soman; Synaptic Transmission | 2003 |
The role of cortical cholinergic pre- and post-synaptic receptors in taste memory formation.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Conditioning, Operant; Long-Term Potentiation; Male; Memory; Microdialysis; Microinjections; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Presynaptic; Scopolamine; Taste | 2003 |
The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system.
Topics: Acetylcholine; Blotting, Northern; DNA; DNA Probes; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-2; Jurkat Cells; Muscarinic Agonists; Oxotremorine; Parasympatholytics; Pirenzepine; Receptors, Interleukin-2; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes | 2003 |
Effects of anticholinergic drugs selective for muscarinic receptor subtypes on prepulse inhibition in mice.
Topics: Animals; Cholinergic Antagonists; Injections, Intraventricular; Male; Mice; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Reflex, Startle; Scopolamine; Tropicamide | 2004 |
Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill.
Topics: Adenylyl Cyclase Inhibitors; Animals; Arecoline; Atropine; Carbachol; Colforsin; Cyclic AMP; Cytoplasmic Granules; Light; Muscarinic Agonists; Muscarinic Antagonists; Perciformes; Pigment Epithelium of Eye; Piperidines; Pirenzepine; Quaternary Ammonium Compounds; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; Retinal Pigments; Second Messenger Systems; Tropicamide | 2004 |
Cholinergic regulation of the evoked quantal release at frog neuromuscular junction.
Topics: Acetylcholine; Action Potentials; Animals; Arecoline; Carbachol; Cholinergic Agonists; Diamines; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Neural Conduction; Neuromuscular Junction; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Parasympatholytics; Pirenzepine; Rana ridibunda; Receptors, Muscarinic; Synaptic Transmission; Tubocurarine | 2004 |
Characterization of functional effects of Z-338, a novel gastroprokinetic agent, on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Humans; Membrane Potentials; Muscarinic Antagonists; Oocytes; Piperidines; Pirenzepine; Potassium; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Reproducibility of Results; Thiazoles; Xenopus | 2004 |
In vitro effects of bethanechol on equine gastrointestinal contractility and functional characterization of involved muscarinic receptor subtypes.
Topics: Animals; Area Under Curve; Bethanechol; Cecum; Dose-Response Relationship, Drug; Duodenum; Female; Gastrointestinal Motility; Horses; Jejunum; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pelvic Floor; Pirenzepine; Receptors, Muscarinic | 2005 |
Muscarinic regulation of neonatal rat bladder spontaneous contractions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcium Channel Agonists; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Diamines; Electric Stimulation; Muscle Contraction; Muscle Hypertonia; Muscle, Smooth; Parasympatholytics; Peptides; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder | 2006 |
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.
Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Emptying; Gastric Fundus; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Physostigmine; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Stomach | 2007 |
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan | 2007 |
Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.
Topics: Action Potentials; Alkaloids; Animals; Carbachol; Chick Embryo; Dose-Response Relationship, Drug; Furans; Heart Ventricles; Myocardial Contraction; Naphthalenes; Piperidines; Pirenzepine; Receptors, Muscarinic | 2007 |
Vitamin A deficiency increases airway resistance following C-fiber stimulation.
Topics: Airway Resistance; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atropine; Capsaicin; Disease Models, Animal; Drug Interactions; Female; Lung; Lung Compliance; Lung Volume Measurements; Nerve Fibers, Unmyelinated; Pirenzepine; Positive-Pressure Respiration; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sulfur Dioxide; Vitamin A Deficiency | 2007 |
In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows.
Topics: Animals; Bethanechol; Cattle; Dairying; Dose-Response Relationship, Drug; Duodenum; Female; In Vitro Techniques; Jejunum; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Tropicamide | 2007 |
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Algorithms; Animals; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Humans; Isoproterenol; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidines; Receptor, Muscarinic M2; Signal Transduction; Transfection | 2007 |
Muscarinic M2 receptor inhibition of calcium current in rat nucleus tractus solitarius.
Topics: Acetylcholine; Animals; Animals, Newborn; Antibodies; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; GTP-Binding Protein alpha Subunits; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M2; Solitary Nucleus | 2007 |
Acetylcholine activity in selective striatal regions supports behavioral flexibility.
Topics: Acetylcholine; Analysis of Variance; Animals; Cognition; Corpus Striatum; Male; Maze Learning; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Pirenzepine; Random Allocation; Rats; Rats, Long-Evans; Receptor, Muscarinic M2; Reversal Learning | 2009 |
Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Male; Microinjections; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Nucleus Accumbens; Oxotremorine; Parasympatholytics; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 2009 |
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
Topics: Adenosine Triphosphate; Animals; Benzhydryl Compounds; Benzofurans; Cresols; Cystitis; Disease Models, Animal; Down-Regulation; Female; Hydrochloric Acid; Mandelic Acids; N-Methylscopolamine; Organophosphonates; Phenols; Phenylpropanolamine; Pirenzepine; Polycyclic Compounds; Pyridoxal Phosphate; Pyrrolidines; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Purinergic; Solifenacin Succinate; Tetrahydroisoquinolines; Tolterodine Tartrate; Urinary Bladder; Urination; Urodynamics | 2010 |
BK channel β1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization.
Topics: Animals; Calcium Channels, L-Type; Excitation Contraction Coupling; In Vitro Techniques; Indoles; Large-Conductance Calcium-Activated Potassium Channel beta Subunits; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pirenzepine; Potassium Channel Blockers; Receptor, Muscarinic M2; Respiratory Mechanics; Signal Transduction; Trachea | 2011 |
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Protein Kinase C; Pyridines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2012 |
Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node.
Topics: Acetylcholine; Animals; Atrioventricular Node; Bee Venoms; Cells, Cultured; Endothelin-1; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Pirenzepine; Potassium Channels, Inwardly Rectifying; Rabbits; Receptor, Muscarinic M2 | 2012 |
Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex.
Topics: Action Potentials; Adult; Biophysics; Carbachol; Cerebral Cortex; Cholinergic Agonists; Drug Combinations; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; Humans; In Vitro Techniques; Male; Muscarinic Antagonists; Patch-Clamp Techniques; Pirenzepine; Pyridines; Receptors, Muscarinic; Thiadiazoles | 2012 |
A role for M(2) and M(3) muscarinic receptors in the contraction of rat and human small airways.
Topics: Animals; Carbachol; Cholinergic Agonists; Humans; In Vitro Techniques; Lung; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Scopolamine Derivatives; Tiotropium Bromide | 2013 |
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.
Topics: Aged; Atropine; Benzofurans; Carbachol; Cell Proliferation; Cells, Cultured; Cholinergic Agonists; Gene Expression; Humans; Male; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Piperidines; Pirenzepine; Proto-Oncogene Proteins c-akt; Pyrrolidines; Receptors, Muscarinic; RNA, Messenger; Urinary Bladder | 2013 |
Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.
Topics: Adult; Aged; Alkaloids; Animals; Cell Proliferation; Collagen; Disease Progression; Extracellular Matrix; Fibroblasts; Furans; Gene Knockdown Techniques; Humans; Mice; Mice, Knockout; Middle Aged; Myopia; Naphthalenes; Piperidines; Pirenzepine; Receptor, Muscarinic M2; RNA, Small Interfering; Sclera; Up-Regulation | 2013 |
Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Animals, Newborn; Carbachol; Cholinergic Agonists; Electric Stimulation; Excitatory Amino Acid Agents; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Muscarinic Agonists; Muscarinic Antagonists; Nerve Fibers; Pirenzepine; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2014 |
Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons.
Topics: Alkenes; Animals; Bicuculline; Cerebellum; Cholinergic Agents; Drug Interactions; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gene Expression Regulation; Male; Neurons; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Piperidines; Pirenzepine; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptic Transmission; Vestibular Nuclei | 2016 |
Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory.
Topics: Animals; Catheters, Indwelling; Cerebral Cortex; Dependovirus; Fear; Gene Knockout Techniques; Genetic Vectors; Hippocampus; Immunohistochemistry; Learning; Male; Memory; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Muscarinic Antagonists; Pirenzepine; Receptors, Muscarinic; Scopolamine | 2016 |
Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle.
Topics: Amides; Animals; Atropine; Carbachol; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Nifedipine; Organ Culture Techniques; Pirenzepine; Pyridines; Ranidae; rho-Associated Kinases | 2018 |
Central muscarinic receptor subtypes (M1 and M3) involved in carbacol-induced hypophagia in neonatal broiler chicken.
Topics: Animals; Animals, Newborn; Behavior, Animal; Carbachol; Chickens; Disease Models, Animal; Eating; Injections, Intraventricular; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M3 | 2020 |
Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock.
Topics: Animals; Atropine; Cytokines; Lipopolysaccharides; Liver; Lung; Macrophages; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Shock, Septic; Tumor Necrosis Factor-alpha | 2019 |