afdx 116 has been researched along with piperidines in 130 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (9.23) | 18.7374 |
| 1990's | 97 (74.62) | 18.2507 |
| 2000's | 15 (11.54) | 29.6817 |
| 2010's | 5 (3.85) | 24.3611 |
| 2020's | 1 (0.77) | 2.80 |
| Authors | Studies |
|---|---|
| Kashima, K; Kataoka, K; Kato, M; Kuriyama, K; Ohkuma, S | 1 |
| Ishihara, H; Shimura, S | 1 |
| Harada, M; Koike, K; Takayanagi, I | 1 |
| Aguilar, JS; Ballesta, JJ; Criado, M; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Gabelt, BT; Kaufman, PL | 2 |
| Frey, KA; Howland, MM | 1 |
| Hendriks, MG; Pfaffendorf, M; Van Zwieten, PA | 2 |
| Badini, I; Beani, L; Bianchi, C; Cintra, A; Fuxe, K; Siniscalchi, A | 1 |
| Ehlert, FJ; Thomas, EA | 1 |
| Bloom, JW; Halonen, M; Mahesh, VK; Nunan, LM; Palmer, JD; Yamamura, HI | 1 |
| Fernandes, LB; Fryer, AD; Hirshman, CA | 1 |
| Funakoshi, A; Jimi, A; Kono, A; Tateishi, K; Tsuru, M; Wakasugi, H | 1 |
| Anderson, DJ; Connolly, T; McKinney, M; Miller, JH; Vella-Rountree, L | 1 |
| Buyse, MA; Fraeyman, NH; Lefebvre, RA | 1 |
| Challiss, RA; Nahorski, SR; Whitham, EM | 1 |
| Böhm, M; Erdmann, E; Gengenbach, S; Hauck, RW; Sunder-Plassmann, L | 1 |
| Bindslev, N; Winding, B | 1 |
| Daniel, EE; Janssen, LJ | 1 |
| Donoff, B; Lad, R; Rangachari, PK | 1 |
| Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E; Tacke, R | 1 |
| Boddeke, HW | 1 |
| Alonso, MJ; Arribas, S; Balfagón, G; Marín, J; Salaices, M | 1 |
| Buxton, IL; Horowitz, B; Zhang, LB | 1 |
| Aikawa, T; Itabashi, S; Ohrui, T; Sasaki, H; Sekizawa, K; Takishima, T | 1 |
| Chiba, S; Furukawa, Y; Nakane, T | 1 |
| Birdsall, NJ; Eveleigh, P; Hulme, EC; Pedder, EK; Poyner, D | 1 |
| Low, PA; Torres, NE; Zollman, PJ | 1 |
| Hersey, SJ; Kajimura, M; Sachs, G; Scott, DR; Wilkes, JM | 1 |
| Benedito, S; García-Sacristán, A; Hernández, M; Prieto, D; Rivera, L | 1 |
| Richards, MH | 1 |
| Boselli, C; Kenakin, TP | 1 |
| Bird, ED; Crino, PB; Plager, MD; Vogt, BA | 1 |
| Chiba, S; Tsukada, M | 1 |
| Baron, E; Boer, R; Eltze, M; Kromer, W | 1 |
| Doods, H; Entzeroth, M; Mayer, N | 1 |
| Bast, A; Doelman, CJ; Nagtegaal, JE; Rodrigues de Miranda, JF; Sprong, RC | 1 |
| Davidson, A; Matus-Leibovitch, N; Mengod, G; Oron, Y | 1 |
| Alger, BE; Pitler, TA | 1 |
| Li, AH; Nattie, EE | 1 |
| Elzinga, CR; Roffel, AF; Zaagsma, J | 1 |
| Harbon, S; Leiber, D; Marc, S | 1 |
| Fleming, N; Laniyonu, A; Sliwinski-Lis, E | 1 |
| Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J | 2 |
| Bloom, JW; Lai, J; Roeske, WR; Yamamura, HI | 1 |
| Entzeroth, M; Mayer, N | 1 |
| Hanack, C; Herawi, M; Kopp, R; Lambrecht, G; Moser, U; Mutschler, E; Pfeiffer, A; Tacke, R | 1 |
| Michel, AD; Whiting, RL | 1 |
| Coppes, RP; Meurs, H; Remie, R; Roffel, AF; Zaagsma, J | 1 |
| Jackson, KN; Kachur, JF; Lowe, VC; Noronha-Blob, L; Sturm, BL | 1 |
| Allen, TG; Burnstock, G | 1 |
| De Boer, P; Horn, AS; Rollema, H; Westerink, BH; Zaagsma, J | 1 |
| Anderson, D; el-Fakahany, EE; Forray, C; McKinney, M | 1 |
| Chiba, S; Haruta, K; Homma, N; Horiuchi, A; Iwatsuki, K; Yonekura, H | 1 |
| Ghataorre, AS; Lambert, DG; Nahorski, SR | 1 |
| Brown, DA; Marrion, NV; Marsh, SJ; Smart, TG | 1 |
| Camus, J; Christophe, J; Waelbroeck, M; Winand, J | 1 |
| Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E | 1 |
| Ruigt, GS; Tonnaer, JA; Van Wezenbeek, LA | 1 |
| Davidesko, D; Doods, HN; Rinner, I; van Charldorp, KJ; van Zwieten, PA | 1 |
| Giraldo, E; Hammer, R; Ladinsky, H; Viganò, MA | 1 |
| Akiba, I; Bujo, H; Kubo, T; Maeda, A; Mishina, M; Nakai, J; Numa, S | 1 |
| Nilvebrant, L; Sparf, B | 1 |
| Davidesko, D; de Jonge, A; Doods, HN; Mathy, MJ; van Charldorp, KJ; van Zwieten, PA | 1 |
| Chiba, S; Nakane, T; Ren, LM | 1 |
| Bai, D; Sattelle, DB | 1 |
| Imaizumi, Y; Kawai, T; Masuda, Y; Ryang, S; Tanaka, M; Watanabe, M; Yamahara, NS | 1 |
| Baird, AW; Farrell, CB; O'Boyle, KM; O'Malley, KE | 1 |
| Kondo, S; Morita, T; Tashima, Y | 1 |
| Dietrich, C; Kilbinger, H | 1 |
| Boselli, C; Grana, E | 1 |
| Burgard, EC; Cote, TE; Sarvey, JM | 1 |
| Gabelt, BT; Kaufman, PL; Poyer, JF | 1 |
| Fukui, H; Inagaki, N; Kondou, H | 1 |
| Imaizumi, Y; Tanaka, M; Watanabe, M; Yamahara, NS | 1 |
| Hamstra, JJ; Roffel, AF; Santing, RE; ten Berge, RE; Zaagsma, J | 1 |
| Robinson, NE; Wang, ZW; Yu, MF | 1 |
| Gillman, TA; Mitchelson, F; Pennefather, JN | 1 |
| Abe, K; Mizutani, A; Nakata, A; Saito, H | 1 |
| Dauphin, F; Hamel, E; Linville, DG | 1 |
| Davenport, TA; Fukumoto, Y; Gousse, A; Kamai, T; Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Baghdoyan, HA; Carlson, BX; Roth, MT | 1 |
| Chen, FF; Hsu, HF; Sung, TC; Wu, D; Yang, CM | 1 |
| Chuang, DM; Fukamauchi, F; Hough, C; Saunders, PA | 1 |
| Wills-Karp, M | 1 |
| Chen, J; Feldmann, BJ; Woldemussie, E | 1 |
| Andrioli, GC; Cavazzani, P; Marchi, M; Raiteri, M; Russo, C | 1 |
| Baker, SA; Ehlert, FJ; Thomas, EA | 1 |
| Baumgold, J; Cohen, VI; De La Cruz, R; Jin, B; Reba, RC; Rzeszotarski, WJ | 1 |
| Frey, KA; Zubieta, JK | 1 |
| Consolo, S; Garcia Ruiz, AJ; La Porta, C; Ladinsky, H; Zambelli, M | 1 |
| Cosentino, M; Crema, A; D'Angelo, L; de Ponti, F; Einaudi, A; Frigo, GM; Lecchini, S | 1 |
| Bechtel, WD; Doods, HN; Engel, W; Ensinger, HA; Entzeroth, M; Ladinsky, H; Mihm, G; Quirion, R; Rudolf, K; Schiavi, GB | 1 |
| Garssen, J; Gierveld, CM; Nijkamp, FP; Van der Vliet, H; Van Loveren, H | 1 |
| Garland, CJ; Hillier, K; Kerr, PM; Wallis, RM | 1 |
| Ehlert, FJ; Ostrom, RS | 2 |
| Arana, R; Bacman, S; Borda, E; Camusso, JJ; Hubscher, O; Sterin-Borda, L | 1 |
| Hanai, H; Kajimura, M; Kaneko, E; Kodaira, M; Lin, S; Takeuchi, K | 1 |
| Haga, N; Itoh, Z; Mizumoto, A; Satoh, M; Yamada, T | 1 |
| Ehlert, FJ; Sawyer, GW | 2 |
| Alfonzo, MJ; de Alfonzo, RG; de Becemberg, IL; de Herrera, VN; de Villaroel, SS; Misle, AJ | 1 |
| Go, ML; Sim, MK; Xu, R | 1 |
| Komori, S; Nakayama, T; Ohashi, H; Unno, T | 1 |
| Mitchelson, F; Shen, A | 1 |
| Rivers, RJ | 1 |
| Ehlert, FJ; Lambrecht, G; Sawyer, GW | 1 |
| Höhle, KD; Möhlig, T; Reinheimer, T; Wessler, I; Zimmermann, S | 1 |
| Fushimi, T; Masuda, T; Saitoh, H; Shimura, S; Shirato, K | 1 |
| Kwon, SC | 1 |
| Gerthoffer, WT; Singer, CA; Vang, S | 1 |
| Kato, T; Ogasawara, M; Sato, K; Shimoda, N; Sugaya, K | 1 |
| Albuquerque, EX; Aracava, Y; Castro, NG; Fawcett, WP; Pereira, EF; Randall, WR; Santos, MD | 1 |
| Mamiya, T; Okuda, A; Ukai, M | 1 |
| Crittenden, EL; García, DM; González, A | 1 |
| Doi, Y; Hayashi, H; Kaibara, M; Murasaki, O; Taniyama, K; Uezono, Y; Yano, K | 1 |
| de Groat, WC; Ng, YK; Wu, HY | 1 |
| Cao, J; Hashiba, K; Kitazawa, T; Komori, S; Taneike, T; Unno, T; Wess, J; Yamada, M | 1 |
| Hirose, K; Kaeriyama, S; Muramatsu, A; Nouchi, H; Sato, M; Shigenobu, K; Shimizu, N; Tanaka, H | 1 |
| Mevissen, M; Meylan, M; Pfeiffer, JB; Portier, CJ; Steiner, A | 1 |
| Ehlert, FJ; Figueroa, KW; Griffin, MT; Liller, S | 1 |
| Kajioka, S; Naito, S; Seki, N; Shahab, N | 1 |
| Barnes, PJ; Brown, SM; Donnelly, LE; Koarai, A; Nicholson, AG; Sturton, RG | 1 |
| Arrighi, N; Bodei, S; Cosciani Cunico, S; Michel, MC; Sigala, S; Simeone, C; Spano, P; Zani, D | 1 |
| Barathi, VA; Beuerman, RW; Goh, LK; Kwan, JL; Seet, LF; Tan, QS; Vithana, EN; Weon, SR | 1 |
| Chen, SR; Pan, HL; Zhu, Y | 1 |
| Hassanpour, S; Lankarani Mohajer, L; Zendehdel, M | 1 |
2 review(s) available for afdx 116 and piperidines
| Article | Year |
|---|---|
Pharmacology and second messenger interactions of cloned muscarinic receptors.
Topics: Animals; Atropine; Carbachol; Cell Line; Humans; Oxotremorine; Piperidines; Pirenzepine; Receptors, Muscarinic; Recombinant Proteins; Second Messenger Systems; Transfection | 1991 |
Therapeutic potential of CNS-active M2 antagonists: novel structures and pharmacology.
Topics: Animals; Benzodiazepinones; Brain; CHO Cells; Cognition Disorders; Cricetinae; Dibenzazepines; Drug Design; Motor Activity; Parasympatholytics; Piperidines; Pirenzepine; Pyridines; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1993 |
128 other study(ies) available for afdx 116 and piperidines
| Article | Year |
|---|---|
Characterization of muscarinic receptor subtypes on rat pancreatic acini: pharmacological identification by secretory responses and binding studies.
Topics: Amylases; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Male; Pancreas; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Sincalide | 1992 |
[The role of muscarinic receptor subtypes in feline tracheal submucosal gland secretion].
Topics: Animals; Atropine; Calcium; Cats; Electrolytes; Glycoproteins; In Vitro Techniques; Mucous Membrane; Piperidines; Pirenzepine; Receptors, Muscarinic; Second Messenger Systems; Trachea | 1992 |
Characterization of subtype of propylbenzilylcholine mustard (PrBCM)-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle.
Topics: 4-Aminopyridine; Alkaloids; Animals; Drug Resistance; Furans; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; Muscle, Smooth; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Propylbenzilylcholine Mustard; Receptors, Muscarinic; Sensitivity and Specificity | 1992 |
Muscarinic receptor subtypes in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Dicyclomine; Muscarine; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1992 |
Inhibition of outflow facility and accommodative and miotic responses to pilocarpine in rhesus monkeys by muscarinic receptor subtype antagonists.
Topics: Accommodation, Ocular; Animals; Aqueous Humor; Female; Intraocular Pressure; Macaca mulatta; Male; Miosis; Muscarinic Antagonists; Parasympatholytics; Phenylephrine; Pilocarpine; Piperidines; Pirenzepine; Pupil | 1992 |
Quantitative autoradiography of muscarinic cholinergic receptor binding in the rat brain: distinction of receptor subtypes in antagonist competition assays.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Male; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine | 1992 |
Characterization of the muscarinic receptor subtype mediating vasodilation in the rat perfused mesenteric vascular bed preparation.
Topics: Animals; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Methacholine Chloride; Parasympatholytics; Perfusion; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Vasodilation | 1992 |
Muscarinic modulation of acetylcholine release from slices of guinea pig nucleus basalis magnocellularis.
Topics: Acetylcholine; Animals; Atropine; Calcium; Choline; Female; Guinea Pigs; Male; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Receptors, Muscarinic; Substantia Innominata; Tetrodotoxin | 1992 |
Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo.
Topics: Alkylating Agents; Animals; Diphenylacetic Acids; Male; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
A minority of muscarinic receptors mediate rabbit tracheal smooth muscle contraction.
Topics: Animals; Atropine; Female; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myocardium; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Radioligand Assay; Receptors, Muscarinic; Trachea | 1992 |
M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.
Topics: Animals; Dogs; Drug Interactions; Isoproterenol; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1992 |
Acetylcholine regulates pancreastatin secretion from the human pancreastatin-producing cell line (QGP-1N).
Topics: Acetylcholine; Adenoma, Islet Cell; Atropine; Calcimycin; Calcium; Carbachol; Chromogranin A; Gastrin-Releasing Peptide; Humans; Pancreatic Hormones; Pancreatic Neoplasms; Parasympatholytics; Peptides; Piperidines; Pirenzepine; Receptors, Muscarinic; Sincalide; Tumor Cells, Cultured | 1991 |
Pharmacological profiles for rat cortical M1 and M2 muscarinic receptors using selective antagonists: comparison with N1E-115 muscarinic receptors.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Diamines; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Phenethylamines; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Tumor Cells, Cultured | 1991 |
Study of the muscarinic receptor subtypes in N1E 115 mouse neuroblastoma cells.
Topics: Animals; Carbachol; Cyclic AMP; Cyclic GMP; Indicators and Reagents; Ligands; Mice; Neuroblastoma; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tumor Cells, Cultured | 1991 |
M3 muscarinic cholinoceptors are linked to phosphoinositide metabolism in rat cerebellar granule cells.
Topics: Animals; Animals, Newborn; Binding, Competitive; Carbachol; Cerebellum; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Male; Parasympatholytics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Beta-adrenergic receptors and m-cholinergic receptors in human lung. Findings following in vivo and in vitro exposure to the beta-adrenergic receptor agonist, terbutaline.
Topics: Aged; Aged, 80 and over; Airway Obstruction; Dose-Response Relationship, Drug; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lung; Middle Aged; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Adrenergic, beta; Receptors, Cholinergic; Terbutaline | 1991 |
Characterization of a muscarinic receptor controlling Cl- secretion in hen trachea.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bumetanide; Calcium Channels; Chickens; Chlorides; Dicyclomine; Female; In Vitro Techniques; Ion Channels; Kinetics; Mucous Membrane; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Pre- and postjunctional muscarinic receptors in canine bronchi.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bethanechol Compounds; Bronchi; Carbachol; Dogs; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
Functional subtyping of muscarinic receptors on canine esophageal mucosa.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Amiloride; Animals; Atropine; Carbachol; Chlorides; Dogs; Electric Conductivity; Esophagus; Female; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Mucous Membrane; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Sodium | 1991 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihypertensive Agents; Aorta, Abdominal; Arecoline; Atropine; Diamines; Endothelium, Vascular; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Norepinephrine; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic | 1991 |
Different effects of muscarinic agonists in rat superior cervical ganglion and hippocampal slices.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Ganglia, Sympathetic; Hippocampus; In Vitro Techniques; Male; Oxotremorine; Parasympathomimetics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains | 1991 |
Presynaptic M2-muscarinic receptors on noradrenergic nerve endings and endothelium-derived M3 receptors in cat cerebral arteries.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Carbachol; Cats; Cerebral Arteries; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasodilation | 1991 |
Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes.
Topics: Animals; Binding, Competitive; Cells, Cultured; Colon; Dogs; Female; GTP-Binding Proteins; Male; Membranes; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Tritium | 1991 |
Pre- and postjunctional muscarinic receptor subtypes in dog airways.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1991 |
Anti-muscarinic effect of alinidine on acetylcholine-induced vasodilation in isolated and perfused dog coronary arteries.
Topics: Acetylcholine; Animals; Carbachol; Clonidine; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Parasympatholytics; Piperidines; Pirenzepine; Vasodilation | 1991 |
Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes.
Topics: Animals; Centrifugation; Cerebral Cortex; Cholic Acids; Digitonin; Gallamine Triethiodide; Heart; In Vitro Techniques; Lacrimal Apparatus; Membranes; Muscarinic Antagonists; Myocardium; Parasympatholytics; Piperidines; Pirenzepine; Rats; Structure-Activity Relationship | 1991 |
Characterization of muscarinic receptor subtype of rat eccrine sweat gland by autoradiography.
Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Eccrine Glands; Kinetics; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tritium | 1991 |
Muscarinic responses of gastric parietal cells.
Topics: Aminopyrine; Animals; Arachidonic Acids; Calcium; Carbachol; Glucose; Image Processing, Computer-Assisted; Ionomycin; N-Methylscopolamine; Parasympatholytics; Parietal Cells, Gastric; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1991 |
Distribution and function of cholinergic receptors in the sheep detrusor muscle.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Parasympathetic; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Piperidines; Pirenzepine; Receptors, Muscarinic; Sheep; Tetraisopropylpyrophosphamide; Urinary Bladder | 1991 |
Biphasic dose-response curves to arecoline in rat atria-mediation by a single promiscuous receptor or two receptor subtypes?
Topics: Animals; Arecoline; Dose-Response Relationship, Drug; GTP-Binding Proteins; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Pertussis Toxin; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Virulence Factors, Bordetella | 1991 |
Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebral Cortex; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Iodocyanopindolol; Ketanserin; Male; Middle Aged; Oxotremorine; Paroxetine; Pindolol; Piperidines; Pirenzepine; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
Predominant acetylcholine-induced vasoconstriction in isolated, perfused simian facial veins.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Diltiazem; Face; Female; In Vitro Techniques; Macaca; Male; Muscle, Smooth, Vascular; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Potassium Chloride; Quinazolines; Receptors, Muscarinic; Saponins; Vasoconstriction; Veins | 1990 |
Telenzepine inhibits electrically-stimulated, acetylcholine plus histamine-mediated acid secretion in the mouse isolated stomach by blockade of M1 muscarine receptors.
Topics: Acetylcholine; Alkaloids; Animals; Anti-Ulcer Agents; Electric Stimulation; Furans; Gastric Acid; Gastric Mucosa; Histamine; Mice; Muscarinic Antagonists; Naphthalenes; p-Methoxy-N-methylphenethylamine; Parasympatholytics; Piperidines; Pirenzepine; Stomach; Thiazepines; Vagus Nerve | 1991 |
Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Cats; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Prejunctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype.
Topics: Animals; Diamines; Electric Stimulation; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Male; Parasympathetic Nervous System; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1991 |
Native Xenopus oocytes express two types of muscarinic receptors.
Topics: Animals; Atropine; Elapid Venoms; Female; Oligonucleotide Probes; Oligonucleotides, Antisense; Oocytes; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Xenopus laevis | 1991 |
Activation of the pharmacologically defined M3 muscarinic receptor depolarizes hippocampal pyramidal cells.
Topics: Animals; Carbachol; Evoked Potentials; Hippocampus; In Vitro Techniques; Kinetics; Parasympatholytics; Piperidines; Pirenzepine; Pyramidal Tracts; Rats; Receptors, Muscarinic | 1990 |
Ventral medulla sites of muscarinic receptor subtypes involved in cardiorespiratory control.
Topics: Animals; Carbon Dioxide; Cardiovascular Physiological Phenomena; Cardiovascular System; Cats; Chemoreceptor Cells; Female; Male; Medulla Oblongata; Parasympatholytics; Phrenic Nerve; Piperidines; Pirenzepine; Receptors, Muscarinic; Respiratory Physiological Phenomena; Respiratory System | 1990 |
Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle.
Topics: Bronchi; Humans; In Vitro Techniques; Ipratropium; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Pharmacological evidence for distinct muscarinic receptor subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea pig myometrium.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Cyclic AMP; Female; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Myometrium; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Type C Phospholipases; Uterine Contraction | 1990 |
Muscarinic M3 receptors are coupled to two signal transduction pathways in rat submandibular cells.
Topics: Animals; Atropine; Carbachol; Cyclic AMP; Parasympatholytics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Signal Transduction; Submandibular Gland | 1990 |
Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle.
Topics: Animals; Cattle; In Vitro Techniques; Inositol Phosphates; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Fibroblasts; Furans; Gene Amplification; Gene Expression; Molecular Sequence Data; Muscarinic Antagonists; Naphthalenes; Phosphatidylinositols; Piperidines; Pirenzepine; Plasmids; Polymerase Chain Reaction; Rats; Receptors, Muscarinic; Transfection | 1990 |
Labeling of rat heart muscarinic receptors using the new M2 selective antagonist [3H]AF-DX 384.
Topics: Affinity Labels; Animals; Atropine; Binding, Competitive; Male; Muscarinic Antagonists; Myocardium; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1990 |
Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors.
Topics: Carbachol; Gastric Mucosa; Humans; In Vitro Techniques; N-Methylscopolamine; Parasympatholytics; Piperazines; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
The binding of [3H]4-diphenylacetoxy-N-methylpiperidine methiodide to longitudinal ileal smooth muscle muscarinic receptors.
Topics: Animals; Binding, Competitive; Diamines; Gallamine Triethiodide; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
Characterization of presynaptic vascular muscarinic receptors inhibiting endogenous noradrenaline overflow in the portal vein of the freely moving rat.
Topics: Animals; Catecholamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrochemistry; Male; Muscle, Smooth, Vascular; Norepinephrine; Piperidines; Pirenzepine; Portal Vein; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Synapses | 1990 |
In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues.
Topics: Animals; Atropine; Calcium; Female; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Structure-Activity Relationship; Thiazepines; Tumor Cells, Cultured; Urinary Bladder; Vas Deferens | 1990 |
M1 and M2 muscarinic receptors mediate excitation and inhibition of guinea-pig intracardiac neurones in culture.
Topics: Action Potentials; Animals; Cells, Cultured; Ganglia; Guinea Pigs; Heart; Membrane Potentials; Muscarine; Neural Inhibition; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
An M3-like muscarinic autoreceptor regulates the in vivo release of acetylcholine in rat striatum.
Topics: Acetylcholine; Animals; Atropine; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Male; Neostigmine; Oxotremorine; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Time Factors | 1990 |
Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.
Topics: Animals; Brain Stem; Corpus Striatum; Cyclic AMP; Diamines; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic | 1989 |
Subtypes of muscarinic receptors in pancreatic exocrine secretion in anesthetized dog.
Topics: Animals; Atropine; Bethanechol Compounds; Dogs; Female; Kinetics; Male; Pancreas; Pancreatic Juice; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Reference Values | 1989 |
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1.
Topics: Arecoline; Atropine; Carbachol; Cell Membrane; Humans; Neuroblastoma; Piperidines; Pirenzepine; Receptors, Muscarinic; Tumor Cells, Cultured | 1989 |
Muscarinic suppression of the M-current in the rat sympathetic ganglion is mediated by receptors of the M1-subtype.
Topics: Animals; Calcium; Gallamine Triethiodide; Ganglia, Spinal; Ganglia, Sympathetic; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Piperidines; Pirenzepine; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Different antagonist binding properties of rat pancreatic and cardiac muscarinic receptors.
Topics: Animals; Binding, Competitive; GTP-Binding Proteins; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Type C Phospholipases | 1987 |
Contribution of M2 alpha and M2 beta muscarinic receptors to the action of cholinergic stimuli on prostaglandin synthesis and mechanical function in the isolated rabbit heart.
Topics: Acetylcholine; Animals; Arecoline; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Prostaglandins; Rabbits; Receptors, Muscarinic | 1988 |
The endogenous muscarinic acetylcholine receptor in Xenopus oocytes is of the M3 subtype.
Topics: Acetylcholine; Animals; Female; In Vitro Techniques; Membrane Potentials; Oocytes; Piperidines; Pirenzepine; Receptors, Cholinergic; Xenopus laevis | 1988 |
Binding of muscarine receptor antagonists to pig coronary smooth muscle.
Topics: Animals; Atropine; Carbachol; Coronary Vessels; Heart Atria; In Vitro Techniques; Muscle, Smooth, Vascular; Piperazines; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Swine; Tritium | 1988 |
Characterization of muscarinic receptors in guinea pig ileum longitudinal smooth muscle.
Topics: Animals; Binding, Competitive; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Myocardium; N-Methylscopolamine; Parasympatholytics; Phenoxybenzamine; Piperidines; Pirenzepine; Receptors, Muscarinic; Salivary Glands; Scopolamine Derivatives | 1988 |
Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA, Recombinant; Glycosylation; Molecular Sequence Data; Muscarine; Oocytes; Piperidines; Pirenzepine; Protein Conformation; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; RNA, Messenger; Sequence Homology, Nucleic Acid; Swine; Xenopus laevis | 1988 |
Receptor binding profiles of some selective muscarinic antagonists.
Topics: Animals; Cerebral Cortex; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Parotid Gland; Piperidines; Pirenzepine; Procyclidine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Urinary Bladder | 1988 |
Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors.
Topics: Animals; Dicyclomine; Ganglia, Sympathetic; Hippocampus; Male; Myocardium; Parasympathomimetics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Submandibular Gland | 1987 |
Muscarinic receptor subtypes mediating vasodilation and vasoconstriction in isolated, perfused simian coronary arteries.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Female; In Vitro Techniques; Macaca; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth, Vascular; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasoconstriction; Vasodilation | 1993 |
Muscarinic acetylcholine receptors on an identified motor neurone in the cockroach, Periplaneta americana.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Atropine; Dose-Response Relationship, Drug; Evoked Potentials; Ganglia, Invertebrate; In Vitro Techniques; Male; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Periplaneta; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine; Vertebrates | 1994 |
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Animals; Arecoline; Bethanechol; Carbachol; Diamines; Dose-Response Relationship, Drug; Furans; Ganglia, Parasympathetic; Ganglionectomy; Iris; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 1995 |
Cholinergic activation of Cl- secretion in rat colonic epithelia.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Binding, Competitive; Chlorides; Cholinergic Agonists; Cholinergic Antagonists; Colon; Dose-Response Relationship, Drug; Epithelium; Hexamethonium; In Vitro Techniques; Ion Transport; Male; Muscarinic Agonists; Parasympatholytics; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Wistar | 1995 |
No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea.
Topics: Animals; Bronchoconstrictor Agents; Cattle; Dose-Response Relationship, Drug; Gallamine Triethiodide; Histamine; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicotinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Adrenergic, beta; Receptors, Muscarinic; Trachea | 1995 |
Muscarinic cholinergic receptor subtypes in human detrusor muscle studied by labeled and nonlabeled pirenzepine, AFDX-116 and 4DAMP.
Topics: Aged; Cystectomy; Female; Humans; Male; Muscle, Smooth; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Urinary Bladder Neoplasms | 1995 |
Prejunctional M1 and postjunctional M3 muscarinic receptors in the circular muscle of the guinea-pig ileum.
Topics: Acetylcholine; Animals; Choline; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1995 |
Mode of antagonism of methoctramine, AF-DX 116 and hexahydrosiladifenidol in guinea-pig left atrium and ileum: comparison of Schild and resultant analysis.
Topics: Animals; Diamines; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Piperidines; Pirenzepine | 1995 |
Muscarinic depression of synaptic transmission and blockade of norepinephrine-induced long-lasting potentiation in the dentate gyrus.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Cyclic AMP; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Muscarine; Norepinephrine; Parasympatholytics; Pertussis Toxin; Piperidines; Pirenzepine; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synapses; Synaptic Transmission; Virulence Factors, Bordetella | 1993 |
The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle.
Topics: Animals; Carbachol; Ciliary Body; Dose-Response Relationship, Drug; In Vitro Techniques; Macaca mulatta; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Pirenzepine; Quinuclidines | 1994 |
Formation of inositol phosphates mediated by M3 muscarinic receptors in type-1 and type-2 astrocytes from neonatal rat cerebral cortex.
Topics: Animals; Animals, Newborn; Astrocytes; Atropine; Carbachol; Cells, Cultured; Cerebral Cortex; Inositol Phosphates; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Tubocurarine | 1994 |
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Diamines; Dose-Response Relationship, Drug; Furans; GTP-Binding Proteins; In Vitro Techniques; Iris; Male; Microinjections; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pertussis Toxin; Phentolamine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Virulence Factors, Bordetella | 1995 |
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity; Diamines; Disease Models, Animal; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart; Histamine; Hypersensitivity; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth; Neuromuscular Junction; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1995 |
Prejunctional muscarinic autoreceptors on horse airway cholinergic nerves.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Fibers; Electric Stimulation; Horses; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1995 |
Muscarinic receptors in rat uterus.
Topics: Alkaloids; Animals; Atropine; Binding, Competitive; Computer Simulation; Female; Furans; In Vitro Techniques; Ligands; Muscarinic Antagonists; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Uterus | 1994 |
Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists.
Topics: Accommodation, Ocular; Animals; Aqueous Humor; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Pupil; Quinuclidines | 1994 |
Facilitatory but nonessential role of the muscarinic cholinergic system in the generation of long-term potentiation of population spikes in the dentate gyrus in vivo.
Topics: Animals; Evoked Potentials; Hippocampus; Injections, Intraventricular; Long-Term Potentiation; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine | 1994 |
Cholinergic dilatation and constriction of feline cerebral blood vessels are mediated by stimulation of phosphoinositide metabolism via two different muscarinic receptor subtypes.
Topics: Animals; Carbachol; Cats; Cerebral Arteries; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Inositol Phosphates; Muscarinic Antagonists; Muscle, Smooth, Vascular; Parasympatholytics; Phosphatidylinositols; Pia Mater; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasoconstriction; Vasodilation | 1994 |
Diabetes-induced alterations in the properties of muscarinic cholinergic receptors in rat vas deferens.
Topics: Animals; Atropine; Binding, Competitive; Diabetes Mellitus, Experimental; Diamines; Insulin; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Up-Regulation; Vas Deferens | 1994 |
Characterization of the muscarinic receptors in the mesenteric vascular bed of spontaneously hypertensive rats.
Topics: Animals; Atropine; Benzodiazepinones; Endothelium, Vascular; Hypertension; Male; Mesenteric Artery, Superior; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Muscarinic; Vasodilation | 1993 |
Pharmacological characterization of muscarinic cholinergic receptors in cat pons and cortex. Preliminary study.
Topics: Animals; Atropine; Binding, Competitive; Cats; Cerebral Cortex; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Pons; Receptors, Muscarinic | 1994 |
Pharmacological characterization of muscarinic receptors in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Kinetics; Muscarine; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1993 |
Agonist-induced down-regulation and antagonist-induced up-regulation of m2- and m3-muscarinic acetylcholine receptor mRNA and protein in cultured cerebellar granule cells.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Cerebellum; Down-Regulation; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; RNA, Messenger; Up-Regulation | 1993 |
Age-related changes in pulmonary muscarinic receptor binding properties.
Topics: Aging; Animals; Binding, Competitive; Guinea Pigs; Lung; Male; Muscarine; Parasympathomimetics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1993 |
Characterization of muscarinic receptors in cultured human iris sphincter and ciliary smooth muscle cells.
Topics: Binding, Competitive; Cells, Cultured; Ciliary Body; Humans; Iris; Muscle, Smooth; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1993 |
Enhancement of glycine release from human brain cortex synaptosomes by acetylcholine acting at M4 muscarinic receptors.
Topics: Acetylcholine; Alkaloids; Cerebral Cortex; Cholinergic Fibers; Drug Synergism; Female; Furans; Glycine; Humans; Kinetics; Male; Muscarinic Antagonists; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Potassium Chloride; Receptors, Muscarinic; Stimulation, Chemical; Synaptic Transmission; Synaptosomes; Tritium | 1993 |
Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum.
Topics: Animals; Cyclic AMP; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Second Messenger Systems | 1993 |
Synthesis and structure-activity relationship of some 5-[[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H- benzo[b,e][1,4]diazepin-11-ones as M2-selective antimuscarinics.
Topics: Animals; Benzodiazepinones; Brain; Mice; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1993 |
Autoradiographic mapping of M3 muscarinic receptors in the rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Male; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Tritium | 1993 |
Differences between rat dorsal and ventral hippocampus in muscarinic receptor agonist binding and interaction with phospholipase C.
Topics: Alkaloids; Animals; Carbachol; Furans; Guanylyl Imidodiphosphate; Hippocampus; Male; Membranes; Mitochondria; N-Methylscopolamine; Naphthalenes; Oxotremorine; Parasympatholytics; Parasympathomimetics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Synaptosomes; Type C Phospholipases | 1993 |
Differential effects of antimuscarinic agents on intestinal motility in the conscious dog.
Topics: Animals; Atropine; Dogs; Female; Gastrointestinal Motility; Heart Rate; Male; Parasympatholytics; Piperidines; Pirenzepine; Pupil; Receptors, Muscarinic | 1993 |
Functional characterization of muscarinic receptors in murine airways.
Topics: Administration, Inhalation; Airway Resistance; Animals; Atropine; Bronchi; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Lung Compliance; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1993 |
Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon.
Topics: Alkaloids; Atropine; Carbachol; Carcinoma; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Furans; Humans; In Vitro Techniques; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Pirenzepine | 1995 |
M2 muscarinic receptor inhibition of agonist-induced cyclic adenosine monophosphate accumulation and relaxation in the guinea pig ileum.
Topics: Animals; Cyclic AMP; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscle Relaxation; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic | 1997 |
Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Animals; Antibodies, Blocking; Atropine; Carbachol; Carbamates; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin G; Isoproterenol; Muscarinic Antagonists; Parasympatholytics; Parotid Gland; Phenylcarbamates; Phosphatidylinositols; Piperidines; Pirenzepine; Protease Inhibitors; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Sjogren's Syndrome | 1996 |
Expression of muscarinic receptor subtypes in rat gastric smooth muscle: effect of M3 selective antagonist on gastric motility and emptying.
Topics: Animals; Atropine; Butylscopolammonium Bromide; Dioxoles; Gastric Emptying; Gastrointestinal Motility; Glucagon; Male; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Pirenzepine; Polymerase Chain Reaction; Rats; Receptors, Muscarinic; Stomach | 1997 |
Muscarinic control of phase III contractions and motilin release in dogs.
Topics: Animals; Cell Separation; Dogs; Duodenum; Female; Infusions, Intravenous; Intestinal Mucosa; Male; Motilin; Muscarinic Antagonists; Piperidines; Pirenzepine; Stomach | 1997 |
Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon.
Topics: Animals; Colforsin; Colon; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella | 1998 |
Two opposite signal transducing mechanisms regulate a G-protein-coupled guanylyl cyclase.
Topics: Animals; Carbachol; Cattle; Cell Membrane; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanylate Cyclase; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Trachea; Virulence Factors, Bordetella | 1998 |
Synthesis, antimuscarinic activity and quantitative structure-activity relationship (QSAR) of tropinyl and piperidinyl esters.
Topics: Animals; Esters; In Vitro Techniques; Kinetics; Male; Models, Molecular; Muscarinic Antagonists; Piperidines; Pirenzepine; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Tropanes | 1998 |
M2 and M3 muscarinic receptors couple, respectively, with activation of nonselective cationic channels and potassium channels in intestinal smooth muscle cells.
Topics: Animals; Atropine; Calcium; Carbachol; Guinea Pigs; Male; Muscarinic Agonists; Muscle, Smooth; Piperidines; Pirenzepine; Potassium Channels; Receptors, Muscarinic | 1998 |
Muscarinic M2 receptor-mediated contraction in the guinea pig Taenia caeci: possible involvement of protein kinase C.
Topics: Animals; Cecum; Colforsin; Diphenylacetic Acids; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Kinetics; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Piperidines; Pirenzepine; Protein Kinase C; Receptor, Muscarinic M2; Receptors, Muscarinic; Second Messenger Systems | 1998 |
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.
Topics: Animals; Colforsin; Diphenylacetic Acids; Guinea Pigs; Histamine; Ileum; Isoproterenol; Muscle Relaxation; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea; Virulence Factors, Bordetella | 1999 |
Pharmacologic study of muscarinic receptor subtypes and arteriolar dilations: a comparison of conducted and local responses.
Topics: Animals; Arterioles; Cheek; Cricetinae; Dose-Response Relationship, Drug; Microcirculation; Mouth Mucosa; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptors, Muscarinic; Reference Values; Scopolamine; Vasodilation | 1999 |
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
Topics: Animals; Colon; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Models, Biological; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella | 1999 |
Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum.
Topics: Adenosine Triphosphate; Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Tetrodotoxin; Virulence Factors, Bordetella | 2000 |
Muscarinic control of histamine release from airways. Inhibitory M1-receptors in human bronchi but absence in rat trachea.
Topics: Acetylcholine; Animals; Bronchi; Calcimycin; Clozapine; Female; Histamine Release; Humans; Ionophores; Male; Mast Cells; Muscarinic Antagonists; Organ Culture Techniques; Oxotremorine; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Species Specificity; Trachea | 2000 |
Secretion and gene expression of secretory leukocyte protease inhibitor by human airway submucosal glands.
Topics: Adult; Aged; Aged, 80 and over; Atropine; Bronchi; Dexamethasone; Dose-Response Relationship, Drug; Exocrine Glands; Female; Gene Expression; Glucocorticoids; Humans; Leukocyte Elastase; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Proteinase Inhibitory Proteins, Secretory; Proteins; Respiratory Mucosa; RNA, Messenger; Secretory Leukocyte Peptidase Inhibitor; Trachea | 2001 |
Mechanisms of acetylcholine-induced vasorelaxation in high K+-stimulated rabbit renal arteries.
Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Channel Blockers; Cations, Monovalent; Endothelium, Vascular; Gadolinium; Imidazoles; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Parasympatholytics; Piperidines; Pirenzepine; Potassium; Rabbits; Renal Artery; Tropicamide; Vasoconstriction; Vasodilation | 2001 |
Coupling of M(2) muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells.
Topics: Animals; Atropine; Cells, Cultured; Colon; Dogs; Female; Gene Expression Regulation, Enzymologic; Genistein; Male; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Pyrazoles; Pyrimidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; src-Family Kinases; Teprotide | 2002 |
[The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction].
Topics: Animals; Atropine; Brain; Female; Muscarine; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder; Urination | 2002 |
Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors.
Topics: Animals; Atropine; Central Nervous System; Cholinesterase Inhibitors; Cholinesterases; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Neurons; Patch-Clamp Techniques; Piperidines; Pirenzepine; Pyramidal Cells; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Receptors, Nicotinic; Soman; Synaptic Transmission | 2003 |
Effects of anticholinergic drugs selective for muscarinic receptor subtypes on prepulse inhibition in mice.
Topics: Animals; Cholinergic Antagonists; Injections, Intraventricular; Male; Mice; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Reflex, Startle; Scopolamine; Tropicamide | 2004 |
Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill.
Topics: Adenylyl Cyclase Inhibitors; Animals; Arecoline; Atropine; Carbachol; Colforsin; Cyclic AMP; Cytoplasmic Granules; Light; Muscarinic Agonists; Muscarinic Antagonists; Perciformes; Pigment Epithelium of Eye; Piperidines; Pirenzepine; Quaternary Ammonium Compounds; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; Retinal Pigments; Second Messenger Systems; Tropicamide | 2004 |
Characterization of functional effects of Z-338, a novel gastroprokinetic agent, on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Humans; Membrane Potentials; Muscarinic Antagonists; Oocytes; Piperidines; Pirenzepine; Potassium; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Reproducibility of Results; Thiazoles; Xenopus | 2004 |
Muscarinic regulation of neonatal rat bladder spontaneous contractions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcium Channel Agonists; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Diamines; Electric Stimulation; Muscle Contraction; Muscle Hypertonia; Muscle, Smooth; Parasympatholytics; Peptides; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder | 2006 |
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.
Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Emptying; Gastric Fundus; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Physostigmine; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Stomach | 2007 |
Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.
Topics: Action Potentials; Alkaloids; Animals; Carbachol; Chick Embryo; Dose-Response Relationship, Drug; Furans; Heart Ventricles; Myocardial Contraction; Naphthalenes; Piperidines; Pirenzepine; Receptors, Muscarinic | 2007 |
In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows.
Topics: Animals; Bethanechol; Cattle; Dairying; Dose-Response Relationship, Drug; Duodenum; Female; In Vitro Techniques; Jejunum; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Tropicamide | 2007 |
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Algorithms; Animals; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Humans; Isoproterenol; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidines; Receptor, Muscarinic M2; Signal Transduction; Transfection | 2007 |
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Protein Kinase C; Pyridines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2012 |
A role for M(2) and M(3) muscarinic receptors in the contraction of rat and human small airways.
Topics: Animals; Carbachol; Cholinergic Agonists; Humans; In Vitro Techniques; Lung; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Scopolamine Derivatives; Tiotropium Bromide | 2013 |
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.
Topics: Aged; Atropine; Benzofurans; Carbachol; Cell Proliferation; Cells, Cultured; Cholinergic Agonists; Gene Expression; Humans; Male; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Piperidines; Pirenzepine; Proto-Oncogene Proteins c-akt; Pyrrolidines; Receptors, Muscarinic; RNA, Messenger; Urinary Bladder | 2013 |
Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.
Topics: Adult; Aged; Alkaloids; Animals; Cell Proliferation; Collagen; Disease Progression; Extracellular Matrix; Fibroblasts; Furans; Gene Knockdown Techniques; Humans; Mice; Mice, Knockout; Middle Aged; Myopia; Naphthalenes; Piperidines; Pirenzepine; Receptor, Muscarinic M2; RNA, Small Interfering; Sclera; Up-Regulation | 2013 |
Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons.
Topics: Alkenes; Animals; Bicuculline; Cerebellum; Cholinergic Agents; Drug Interactions; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gene Expression Regulation; Male; Neurons; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Piperidines; Pirenzepine; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptic Transmission; Vestibular Nuclei | 2016 |
Central muscarinic receptor subtypes (M1 and M3) involved in carbacol-induced hypophagia in neonatal broiler chicken.
Topics: Animals; Animals, Newborn; Behavior, Animal; Carbachol; Chickens; Disease Models, Animal; Eating; Injections, Intraventricular; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M3 | 2020 |