Page last updated: 2024-09-02

afdx 116 and physostigmine

afdx 116 has been researched along with physostigmine in 12 studies

Compound Research Comparison

Studies
(afdx 116)
Trials
(afdx 116)
Recent Studies (post-2010)
(afdx 116)
Studies
(physostigmine)
Trials
(physostigmine)
Recent Studies (post-2010) (physostigmine)
3671246,230252331

Protein Interaction Comparison

ProteinTaxonomyafdx 116 (IC50)physostigmine (IC50)
AcetylcholinesteraseElectrophorus electricus (electric eel)0.1666
AcetylcholinesteraseTetronarce californica (Pacific electric ray)0.3023
CholinesteraseHomo sapiens (human)0.3055
Cytochrome P450 2D6Homo sapiens (human)0.2
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.857
AcetylcholinesteraseMus musculus (house mouse)0.0269
AcetylcholinesteraseHomo sapiens (human)0.0853
Acetylcholinesterase Bos taurus (cattle)0.7197
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.857
Delta-type opioid receptorMus musculus (house mouse)1.1821
AcetylcholinesteraseGallus gallus (chicken)0.02
AcetylcholinesteraseRattus norvegicus (Norway rat)0.0416
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.857
CholinesteraseEquus caballus (horse)0.4081
CholinesteraseMus musculus (house mouse)0.28
Acyl-CoA:cholesterol acyltransferase Oryctolagus cuniculus (rabbit)0.0189
Carboxylic ester hydrolase Rattus norvegicus (Norway rat)0.018
Carboxylic ester hydrolase Equus caballus (horse)1.263

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's8 (66.67)18.2507
2000's3 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bachoo, M; Polosa, C1
Badini, I; Beani, L; Bianchi, C; Cintra, A; Fuxe, K; Siniscalchi, A1
Fujimoto, K; Hayakawa, T; Kashima, Y; Kawashima, K; Oohata, H; Suzuki, T1
Chiba, S; Tsukada, M1
Murugaian, J; Sapru, H; Sundaram, K; Watson, M1
Aslan, AN; Oktay, S; Onat, F; Ozkutlu, U1
Baratti, CM; Kopf, SR; Opezzo, JW1
Bargas, J; Bermudez-Rattoni, F; Galarraga, E; Hernández-López, S; Miranda, I; Reyes, A; Vilchis, C1
García-Sacristán, A; Prieto, D; Simonsen, U; Triguero, D1
de Groat, WC; Ng, YK; Wu, HY1
Cao, J; Hashiba, K; Kitazawa, T; Komori, S; Taneike, T; Unno, T; Wess, J; Yamada, M1
Arreola, JL; Chávez, J; Flores-Soto, E; Montaño, LM; Segura, P; Vargas, MH1

Other Studies

12 other study(ies) available for afdx 116 and physostigmine

ArticleYear
An AF-DX 116 sensitive inhibitory mechanism modulates nicotinic and muscarinic transmission in cat superior cervical ganglion in the presence of anticholinesterase.
    Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:12

    Topics: Action Potentials; Animals; Cats; Cholinesterase Inhibitors; Ganglia, Sympathetic; Hexamethonium Compounds; Parasympatholytics; Parasympathomimetics; Physostigmine; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission

1992
Muscarinic modulation of acetylcholine release from slices of guinea pig nucleus basalis magnocellularis.
    Neuroscience letters, 1992, Jun-22, Volume: 140, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Calcium; Choline; Female; Guinea Pigs; Male; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Receptors, Muscarinic; Substantia Innominata; Tetrodotoxin

1992
Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay.
    Journal of neurochemistry, 1991, Volume: 57, Issue:3

    Topics: Acetylcholine; Administration, Topical; Animals; Atropine; Corpus Striatum; Dialysis; Male; Muscarine; Parasympatholytics; Physostigmine; Pirenzepine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1991
Predominant acetylcholine-induced vasoconstriction in isolated, perfused simian facial veins.
    European journal of pharmacology, 1990, Dec-04, Volume: 191, Issue:3

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Diltiazem; Face; Female; In Vitro Techniques; Macaca; Male; Muscle, Smooth, Vascular; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Potassium Chloride; Quinazolines; Receptors, Muscarinic; Saponins; Vasoconstriction; Veins

1990
M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii.
    Brain research, 1989, Jan-16, Volume: 477, Issue:1-2

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Blood Pressure; Glutamates; Heart Rate; Male; Medulla Oblongata; Microinjections; Physostigmine; Pirenzepine; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Reference Values

1989
Central muscarinic M2 cholinoceptors involved in cholinergic hypertension.
    European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3

    Topics: Animals; Blood Pressure; Diamines; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Muscarinic Antagonists; Oxotremorine; Physostigmine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic

1993
Facilitation of memory storage by the acetylcholine M2 muscarinic receptor antagonist AF-DX 116.
    Behavioral and neural biology, 1993, Volume: 60, Issue:1

    Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Brain; Drug Synergism; Male; Memory; Mice; Neostigmine; Parasympatholytics; Physostigmine; Pirenzepine; Receptors, Muscarinic

1993
Cholinergic modulation of neostriatal output: a functional antagonism between different types of muscarinic receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, May-01, Volume: 19, Issue:9

    Topics: Acetylcholine; Animals; Cadmium Chloride; Cesium; Chlorides; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Physostigmine; Pirenzepine; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Tetrodotoxin

1999
Cholinergic modulation of non-adrenergic, non-cholinergic relaxation in isolated, small coronary arteries from lambs.
    Pflugers Archiv : European journal of physiology, 1999, Volume: 438, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholinesterase; Adrenergic alpha-Antagonists; Animals; Capsaicin; Choline O-Acetyltransferase; Coronary Vessels; Electric Stimulation; In Vitro Techniques; Microcirculation; Myography; Norepinephrine; Phentolamine; Physostigmine; Pirenzepine; Propranolol; Sheep; Suramin; Vasoconstrictor Agents; Vasodilation

1999
Muscarinic regulation of neonatal rat bladder spontaneous contractions.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 291, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcium Channel Agonists; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Diamines; Electric Stimulation; Muscle Contraction; Muscle Hypertonia; Muscle, Smooth; Parasympatholytics; Peptides; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder

2006
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.
    European journal of pharmacology, 2007, Jan-12, Volume: 554, Issue:2-3

    Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Emptying; Gastric Fundus; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Physostigmine; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Stomach

2007
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:4

    Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan

2007