afdx 116 has been researched along with physostigmine in 12 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (physostigmine) | Trials (physostigmine) | Recent Studies (post-2010) (physostigmine) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 6,230 | 252 | 331 |
| Protein | Taxonomy | afdx 116 (IC50) | physostigmine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.1666 | |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | 0.3023 | |
| Cholinesterase | Homo sapiens (human) | 0.3055 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.2 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.857 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 0.0269 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.0853 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.7197 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.857 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 1.1821 | |
| Acetylcholinesterase | Gallus gallus (chicken) | 0.02 | |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | 0.0416 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.857 | |
| Cholinesterase | Equus caballus (horse) | 0.4081 | |
| Cholinesterase | Mus musculus (house mouse) | 0.28 | |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | 0.0189 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 0.018 | |
| Carboxylic ester hydrolase | Equus caballus (horse) | 1.263 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 8 (66.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bachoo, M; Polosa, C | 1 |
| Badini, I; Beani, L; Bianchi, C; Cintra, A; Fuxe, K; Siniscalchi, A | 1 |
| Fujimoto, K; Hayakawa, T; Kashima, Y; Kawashima, K; Oohata, H; Suzuki, T | 1 |
| Chiba, S; Tsukada, M | 1 |
| Murugaian, J; Sapru, H; Sundaram, K; Watson, M | 1 |
| Aslan, AN; Oktay, S; Onat, F; Ozkutlu, U | 1 |
| Baratti, CM; Kopf, SR; Opezzo, JW | 1 |
| Bargas, J; Bermudez-Rattoni, F; Galarraga, E; Hernández-López, S; Miranda, I; Reyes, A; Vilchis, C | 1 |
| García-Sacristán, A; Prieto, D; Simonsen, U; Triguero, D | 1 |
| de Groat, WC; Ng, YK; Wu, HY | 1 |
| Cao, J; Hashiba, K; Kitazawa, T; Komori, S; Taneike, T; Unno, T; Wess, J; Yamada, M | 1 |
| Arreola, JL; Chávez, J; Flores-Soto, E; Montaño, LM; Segura, P; Vargas, MH | 1 |
12 other study(ies) available for afdx 116 and physostigmine
| Article | Year |
|---|---|
An AF-DX 116 sensitive inhibitory mechanism modulates nicotinic and muscarinic transmission in cat superior cervical ganglion in the presence of anticholinesterase.
Topics: Action Potentials; Animals; Cats; Cholinesterase Inhibitors; Ganglia, Sympathetic; Hexamethonium Compounds; Parasympatholytics; Parasympathomimetics; Physostigmine; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission | 1992 |
Muscarinic modulation of acetylcholine release from slices of guinea pig nucleus basalis magnocellularis.
Topics: Acetylcholine; Animals; Atropine; Calcium; Choline; Female; Guinea Pigs; Male; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Receptors, Muscarinic; Substantia Innominata; Tetrodotoxin | 1992 |
Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay.
Topics: Acetylcholine; Administration, Topical; Animals; Atropine; Corpus Striatum; Dialysis; Male; Muscarine; Parasympatholytics; Physostigmine; Pirenzepine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Predominant acetylcholine-induced vasoconstriction in isolated, perfused simian facial veins.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Diltiazem; Face; Female; In Vitro Techniques; Macaca; Male; Muscle, Smooth, Vascular; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Potassium Chloride; Quinazolines; Receptors, Muscarinic; Saponins; Vasoconstriction; Veins | 1990 |
M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Blood Pressure; Glutamates; Heart Rate; Male; Medulla Oblongata; Microinjections; Physostigmine; Pirenzepine; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Reference Values | 1989 |
Central muscarinic M2 cholinoceptors involved in cholinergic hypertension.
Topics: Animals; Blood Pressure; Diamines; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Muscarinic Antagonists; Oxotremorine; Physostigmine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1993 |
Facilitation of memory storage by the acetylcholine M2 muscarinic receptor antagonist AF-DX 116.
Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Brain; Drug Synergism; Male; Memory; Mice; Neostigmine; Parasympatholytics; Physostigmine; Pirenzepine; Receptors, Muscarinic | 1993 |
Cholinergic modulation of neostriatal output: a functional antagonism between different types of muscarinic receptors.
Topics: Acetylcholine; Animals; Cadmium Chloride; Cesium; Chlorides; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Physostigmine; Pirenzepine; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Tetrodotoxin | 1999 |
Cholinergic modulation of non-adrenergic, non-cholinergic relaxation in isolated, small coronary arteries from lambs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholinesterase; Adrenergic alpha-Antagonists; Animals; Capsaicin; Choline O-Acetyltransferase; Coronary Vessels; Electric Stimulation; In Vitro Techniques; Microcirculation; Myography; Norepinephrine; Phentolamine; Physostigmine; Pirenzepine; Propranolol; Sheep; Suramin; Vasoconstrictor Agents; Vasodilation | 1999 |
Muscarinic regulation of neonatal rat bladder spontaneous contractions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcium Channel Agonists; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Diamines; Electric Stimulation; Muscle Contraction; Muscle Hypertonia; Muscle, Smooth; Parasympatholytics; Peptides; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder | 2006 |
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.
Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Emptying; Gastric Fundus; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Physostigmine; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Stomach | 2007 |
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan | 2007 |