afdx 116 has been researched along with n-methylscopolamine in 35 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (n-methylscopolamine) | Trials (n-methylscopolamine) | Recent Studies (post-2010) (n-methylscopolamine) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 1,026 | 12 | 52 |
| Protein | Taxonomy | afdx 116 (IC50) | n-methylscopolamine (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.335 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0023 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.0023 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0018 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.0011 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (37.14) | 18.7374 |
| 1990's | 18 (51.43) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pinkas-Kramarski, R; Sokolovsky, M; Stein, R | 1 |
| Ehlert, FJ; Thomas, EA | 2 |
| Atkins, PT; Kitai, ST; Nishi, K; Surmeier, DJ | 1 |
| Hersey, SJ; Kajimura, M; Sachs, G; Scott, DR; Wilkes, JM | 1 |
| Annis, SJ; Ehlert, FJ; Leslie, FM; Smith, TD | 1 |
| Bonner, TI; Brann, MR; Wess, J | 1 |
| Hanack, C; Herawi, M; Kopp, R; Lambrecht, G; Moser, U; Mutschler, E; Pfeiffer, A; Tacke, R | 1 |
| Ehlert, FJ; Tran, LP | 1 |
| Fujimoto, K; Kawashima, K; Oohata, H; Suzuki, T | 1 |
| Delen, FM; Ehlert, FJ; Liem, HA; Yun, SH | 1 |
| Haga, T; Honda, N; Ichiyama, A; Kajimura, M; Kaneko, E | 1 |
| Ackerman, MS; Korc, M; Roeske, WR | 1 |
| Palm, D; Pitschner, HF; Schlepper, M; Schulte, B; Wellstein, A | 1 |
| Michel, AD; Stefanich, E; Whiting, RL | 1 |
| Delen, FM; Ehlert, FJ; Friedman, DJ; Self, DW; Yun, SH | 1 |
| Brown, DA; Marrion, NV; Marsh, SJ; Smart, TG | 1 |
| Anderson, W; Dickinson, KE; Hirschowitz, BI; Matsumoto, H; Pruitt, RE; Uemura, N | 1 |
| Camus, J; Christophe, J; Waelbroeck, M; Winand, J | 1 |
| Giraldo, E; Hammer, R; Ladinsky, H; Viganò, MA | 1 |
| Michel, AD; Whiting, RL | 1 |
| De Paoli, AM; Giraldo, E; Hammer, R; Martos, F; Monferini, E | 1 |
| Giraldo, E; Hammer, R; Ladinsky, H; Monferini, E; Schiavi, GB | 1 |
| Baylis, HA; Bunting, R; Mason, WT; Millar, NS; Reaper, C; Sattelle, DB | 1 |
| Jakubík, J; Tucek, S | 1 |
| Chen, FF; Hsu, HF; Sung, TC; Wu, D; Yang, CM | 1 |
| Greten, H; Mirau, S; Raedler, A; Sievers, J; von Schrenck, T | 1 |
| Cappello, B; Di Carlo, R; Greco, G; Meli, R; Muccioli, G; Novellino, E; Perissutti, E; Santagada, V; Silipo, C; Vittoria, A | 1 |
| Consolo, S; Garcia Ruiz, AJ; La Porta, C; Ladinsky, H; Zambelli, M | 1 |
| Bacáková, L; el-Fakahany, EE; Jakubík, J; Tucek, S | 1 |
| Ehlert, FJ; Lambrecht, G; Sawyer, GW | 1 |
| Christopoulos, A; Lanzafame, A; Mitchelson, F | 1 |
| Blackstone, K; Pratt, WE | 1 |
| Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A | 1 |
1 review(s) available for afdx 116 and n-methylscopolamine
| Article | Year |
|---|---|
Cardioselective muscarinic antagonists.
Topics: Animals; Carbachol; Cardiotonic Agents; Carrier Proteins; Cyclic AMP; Cyclic AMP Receptor Protein; Dose-Response Relationship, Drug; Heart; N-Methylscopolamine; Oxotremorine; Phorbol Esters; Pirenzepine; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
34 other study(ies) available for afdx 116 and n-methylscopolamine
| Article | Year |
|---|---|
Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Atropine; Carbachol; Cell Line; Cloning, Molecular; GTP-Binding Proteins; Oxotremorine; Phosphatidylinositols; Rats; Receptors, Muscarinic; Recombinant Proteins | 1988 |
Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo.
Topics: Alkylating Agents; Animals; Diphenylacetic Acids; Male; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
Muscarinic regulation of cyclic AMP metabolism in rat neostriatal cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cells, Cultured; Corpus Striatum; Cyclic AMP; Embryo, Mammalian; Kinetics; N-Methylscopolamine; Neurons; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Muscarinic responses of gastric parietal cells.
Topics: Aminopyrine; Animals; Arachidonic Acids; Calcium; Carbachol; Glucose; Image Processing, Computer-Assisted; Ionomycin; N-Methylscopolamine; Parasympatholytics; Parietal Cells, Gastric; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1991 |
N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Drug Interactions; Male; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1991 |
Chimeric m2/m3 muscarinic receptors: role of carboxyl terminal receptor domains in selectivity of ligand binding and coupling to phosphoinositide hydrolysis.
Topics: Animals; Cells, Cultured; Diamines; Hydrolysis; Ligands; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship | 1990 |
Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors.
Topics: Carbachol; Gastric Mucosa; Humans; In Vitro Techniques; N-Methylscopolamine; Parasympatholytics; Piperazines; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Choline; Kinetics; Male; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1990 |
Pharmacological differentiation of presynaptic M1 muscarinic receptors modulating acetylcholine release from postsynaptic muscarinic receptors in guinea-pig ileum.
Topics: Acetylcholine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Synapses | 1990 |
The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart.
Topics: Adenylyl Cyclase Inhibitors; Amitriptyline; Animals; Brain; Doxepin; Heart; Imipramine; In Vitro Techniques; Male; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Carbachol-induced potentiation and inhibition of acid secretion by guinea pig gastric gland.
Topics: Aminopyrine; Animals; Atropine; Binding, Competitive; Carbachol; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine; In Vitro Techniques; Male; N-Methylscopolamine; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
A cholinergic antagonist identifies a subclass of muscarinic receptors in isolated rat pancreatic acini.
Topics: Amylases; Animals; Atropine; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
AF-DX 116 discriminates heart from gland M2-cholinoceptors in man.
Topics: Adult; Animals; Atropine; Blood Pressure; Cattle; Cell Membrane; Cerebral Cortex; Heart Rate; Humans; Kinetics; Male; Myocardium; N-Methylscopolamine; Organ Specificity; Pirenzepine; Propranolol; Receptors, Cholinergic; Reference Values; Saliva; Salivary Glands; Scopolamine Derivatives; Swine | 1989 |
Direct labeling of rat M3-muscarinic receptors by [3H]4DAMP.
Topics: Adamantane; Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Ligands; N-Methylscopolamine; Pirenzepine; Proteins; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland | 1989 |
Coupling of subtypes of the muscarinic receptor to adenylate cyclase in the corpus striatum and heart.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; Corpus Striatum; Gallamine Triethiodide; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives | 1989 |
Muscarinic suppression of the M-current in the rat sympathetic ganglion is mediated by receptors of the M1-subtype.
Topics: Animals; Calcium; Gallamine Triethiodide; Ganglia, Spinal; Ganglia, Sympathetic; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Piperidines; Pirenzepine; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Esophagus; Imipramine; Kinetics; N-Methylscopolamine; Oxotremorine; Pepsinogens; Pirenzepine; Propranolol; Radioligand Assay; Rana catesbeiana; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Different antagonist binding properties of rat pancreatic and cardiac muscarinic receptors.
Topics: Animals; Binding, Competitive; GTP-Binding Proteins; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Type C Phospholipases | 1987 |
Characterization of muscarinic receptors in guinea pig ileum longitudinal smooth muscle.
Topics: Animals; Binding, Competitive; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Myocardium; N-Methylscopolamine; Parasympatholytics; Phenoxybenzamine; Piperidines; Pirenzepine; Receptors, Muscarinic; Salivary Glands; Scopolamine Derivatives | 1988 |
Direct binding studies on ileal and cardiac muscarinic receptors.
Topics: Animals; Gallamine Triethiodide; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Membranes; Muscle, Smooth; Myocardium; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Characterization of muscarinic receptors in salivary and lacrimal glands of the rat.
Topics: Animals; Atropine Derivatives; Dicyclomine; Exocrine Glands; In Vitro Techniques; Lacrimal Apparatus; Male; N-Methylscopolamine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Salivary Glands; Scopolamine Derivatives; Synaptosomes | 1987 |
Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Cell Membrane; Cerebellum; Cerebral Cortex; Kinetics; Lacrimal Apparatus; Male; Myocardium; N-Methylscopolamine; Organ Specificity; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland | 1986 |
Functional expression of a cloned Drosophila muscarinic acetylcholine receptor in a stable Drosophila cell line.
Topics: Animals; Calcium; Cell Line; Cloning, Molecular; Drosophila melanogaster; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Fura-2; Gene Expression Regulation; Microscopy, Fluorescence; Molecular Weight; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1995 |
Two populations of muscarinic binding sites in the chick heart distinguished by affinities for ligands and selective inactivation.
Topics: Alcuronium; Animals; Chickens; Choline; Cholinergic Agents; Diamines; Female; In Vitro Techniques; Ligands; Male; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives | 1994 |
Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Cyclic AMP; Guanosine Triphosphate; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Signal Transduction; Virulence Factors, Bordetella | 1994 |
Pharmacological characterization of muscarinic receptors in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Kinetics; Muscarine; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1993 |
Characterization of muscarinic receptors on guinea pig gallbladder smooth muscle.
Topics: Animals; Autoradiography; Carbachol; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tetrodotoxin | 1993 |
Synthesis and muscarinic receptor binding profiles of antagonist benzotriazole derivatives.
Topics: Animals; Chromatography, Thin Layer; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Triazoles | 1993 |
Differences between rat dorsal and ventral hippocampus in muscarinic receptor agonist binding and interaction with phospholipase C.
Topics: Alkaloids; Animals; Carbachol; Furans; Guanylyl Imidodiphosphate; Hippocampus; Male; Membranes; Mitochondria; N-Methylscopolamine; Naphthalenes; Oxotremorine; Parasympatholytics; Parasympathomimetics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Synaptosomes; Type C Phospholipases | 1993 |
Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; Humans; Inositol Phosphates; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Transfection; Tritium | 1995 |
Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum.
Topics: Adenosine Triphosphate; Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Tetrodotoxin; Virulence Factors, Bordetella | 2000 |
The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria.
Topics: Acetylcholine; Allosteric Regulation; Animals; Atropine; Carbachol; Cardiotonic Agents; Dexetimide; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Nicotinic Antagonists; Parasympatholytics; Phthalimides; Pirenzepine; Quaternary Ammonium Compounds; Radioligand Assay; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Male; Microinjections; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Nucleus Accumbens; Oxotremorine; Parasympatholytics; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 2009 |
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
Topics: Adenosine Triphosphate; Animals; Benzhydryl Compounds; Benzofurans; Cresols; Cystitis; Disease Models, Animal; Down-Regulation; Female; Hydrochloric Acid; Mandelic Acids; N-Methylscopolamine; Organophosphonates; Phenols; Phenylpropanolamine; Pirenzepine; Polycyclic Compounds; Pyridoxal Phosphate; Pyrrolidines; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Purinergic; Solifenacin Succinate; Tetrahydroisoquinolines; Tolterodine Tartrate; Urinary Bladder; Urination; Urodynamics | 2010 |