afdx 116 has been researched along with muscarine in 23 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (muscarine) | Trials (muscarine) | Recent Studies (post-2010) (muscarine) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 971 | 1 | 74 |
| Protein | Taxonomy | afdx 116 (IC50) | muscarine (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 2.1745 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 4.263 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.012 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.241 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.012 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 2.0755 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 13 (56.52) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aguilar, JS; Ballesta, JJ; Criado, M; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Jiang, ZG; North, RA; Sugita, S; Uchimura, N | 1 |
| Inoue, M; Kuriyama, H | 1 |
| Nishimura, S; Sorimachi, M; Yamagami, K | 1 |
| Fujimoto, K; Hayakawa, T; Kashima, Y; Kawashima, K; Oohata, H; Suzuki, T | 1 |
| Aceves, J; Brassart, JL; Góngora-Alfaro, JL; Hernández-López, S; Martínez-Fong, D | 1 |
| Allen, TG; Burnstock, G | 1 |
| Kobayashi, H; Mochida, S | 1 |
| Galvan, M | 1 |
| Connolly, GP; Newberry, NR | 1 |
| Gilbert, MJ; Newberry, NR | 1 |
| Ellerbrock, BR; Hoss, W; Messer, WS; Smith, DA | 1 |
| Boer, R; Galvan, M; Schudt, C | 1 |
| Giachetti, A; Micheletti, R; Montagna, E | 1 |
| Chung, FZ; Lai, J; Mei, L; Roeske, WR; Venter, JC; Yamamura, HI | 1 |
| Akiba, I; Bujo, H; Kubo, T; Maeda, A; Mishina, M; Nakai, J; Numa, S | 1 |
| Burgard, EC; Cote, TE; Sarvey, JM | 1 |
| Akaike, N; Furukawa, K; Nabekura, J | 1 |
| Chen, FF; Hsu, HF; Sung, TC; Wu, D; Yang, CM | 1 |
| Wills-Karp, M | 1 |
| Bargas, J; Galarraga, E; Hernández-Echeagaray, E | 1 |
| Bargas, J; Bermudez-Rattoni, F; Galarraga, E; Hernández-López, S; Miranda, I; Reyes, A; Vilchis, C | 1 |
| Kato, T; Ogasawara, M; Sato, K; Shimoda, N; Sugaya, K | 1 |
23 other study(ies) available for afdx 116 and muscarine
| Article | Year |
|---|---|
Muscarinic receptor subtypes in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Dicyclomine; Muscarine; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1992 |
Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain; Corpus Striatum; Diamines; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Kinetics; Muscarine; Neurons; Nucleus Accumbens; Organ Specificity; Parasympatholytics; Pirenzepine; Quinoxalines; Rats; Receptors, Muscarinic; Synapses | 1991 |
Muscarinic receptor is coupled with a cation channel through a GTP-binding protein in guinea-pig chromaffin cells.
Topics: Adrenal Medulla; Animals; Barium; Calcium; Dose-Response Relationship, Drug; Female; GTP-Binding Proteins; Guinea Pigs; Ion Channels; Male; Membrane Potentials; Muscarine; Oxotremorine; Pirenzepine; Receptors, Muscarinic; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Internal Ca2+ mobilization by muscarinic stimulation increases secretion from adrenal chromaffin cells only in the presence of Ca2+ influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Atropine; Calcium; Catecholamines; Cats; Cattle; Cytosol; Gallopamil; Kinetics; Methacholine Chloride; Muscarine; Nicotine; Parasympatholytics; Pilocarpine; Pirenzepine; Receptors, Muscarinic | 1991 |
Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay.
Topics: Acetylcholine; Administration, Topical; Animals; Atropine; Corpus Striatum; Dialysis; Male; Muscarine; Parasympatholytics; Physostigmine; Pirenzepine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Activation of nigral M1 and M2 muscarinic receptors produces opposing effects on striatal 3,4-dihydroxyphenylacetic acid measured by in vivo voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Electrochemistry; Functional Laterality; Male; Muscarine; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stereotaxic Techniques; Substantia Nigra | 1991 |
M1 and M2 muscarinic receptors mediate excitation and inhibition of guinea-pig intracardiac neurones in culture.
Topics: Action Potentials; Animals; Cells, Cultured; Ganglia; Guinea Pigs; Heart; Membrane Potentials; Muscarine; Neural Inhibition; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
Activation of M2 muscarinic receptors causes an alteration of action potentials by modulation of Ca entry in isolated sympathetic neurons of rabbits.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Action Potentials; Animals; Calcium; Cells, Cultured; Ganglia, Sympathetic; Male; Muscarine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic | 1986 |
Modulation of synaptic transmission in autonomic ganglia mediated via the activation of postganglionic muscarinic M1 receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Ganglia, Autonomic; Ganglia, Sympathetic; In Vitro Techniques; Muscarine; Pirenzepine; Rabbits; Rats; Receptors, Muscarinic; Synapses; Synaptic Transmission | 1988 |
Muscarinic pharmacology of the spinal cord of the neonatal rat in vitro.
Topics: Action Potentials; Animals; Animals, Newborn; Atropine; In Vitro Techniques; Muscarine; Pirenzepine; Rats; Rats, Inbred Strains; Spinal Cord | 1989 |
Biphasic dose-response curve to muscarine on the rat superior cervical ganglion.
Topics: Animals; Dose-Response Relationship, Drug; Gallamine Triethiodide; Ganglia, Spinal; In Vitro Techniques; Muscarine; Pertussis Toxin; Pirenzepine; Rats; Virulence Factors, Bordetella | 1989 |
Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations.
Topics: Animals; Autoradiography; Brain; Computer Simulation; Diencephalon; Mesencephalon; Molecular Conformation; Molecular Structure; Muscarine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Rhombencephalon; Structure-Activity Relationship; Telencephalon; Thermodynamics; Tissue Distribution | 1989 |
Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Male; Membrane Potentials; Muscarine; Parasympatholytics; Pirenzepine; Rabbits; Rats; Receptors, Muscarinic; Time Factors | 1989 |
AF-DX 116, a cardioselective muscarinic antagonist.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Cats; Dimethylphenylpiperazinium Iodide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastric Acid; Gastric Emptying; Guinea Pigs; Heart; Heart Rate; Male; Muscarine; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Pirenzepine; Rats; Receptors, Muscarinic | 1987 |
The cloned murine M1 muscarinic receptor is associated with the hydrolysis of phosphatidylinositols in transfected murine B82 cells.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Cell Line; Cell Membrane; DNA, Recombinant; Fibroblasts; Guanylyl Imidodiphosphate; Hydrolysis; Mice; Muscarine; Nucleic Acid Hybridization; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Recombinant Proteins; Sequence Homology, Nucleic Acid; Transfection | 1988 |
Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA, Recombinant; Glycosylation; Molecular Sequence Data; Muscarine; Oocytes; Piperidines; Pirenzepine; Protein Conformation; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; RNA, Messenger; Sequence Homology, Nucleic Acid; Swine; Xenopus laevis | 1988 |
Muscarinic depression of synaptic transmission and blockade of norepinephrine-induced long-lasting potentiation in the dentate gyrus.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Cyclic AMP; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Muscarine; Norepinephrine; Parasympatholytics; Pertussis Toxin; Piperidines; Pirenzepine; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synapses; Synaptic Transmission; Virulence Factors, Bordetella | 1993 |
Nicotinic and muscarinic acetylcholine responses in differentiated PC12 cells.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Differentiation; Cell Membrane Permeability; Egtazic Acid; Hexamethonium; Hexamethonium Compounds; Membrane Potentials; Muscarine; Nerve Growth Factors; Nicotine; Nystatin; Parasympatholytics; PC12 Cells; Pirenzepine; Potassium; Receptors, Muscarinic; Receptors, Nicotinic; Tubocurarine | 1994 |
Pharmacological characterization of muscarinic receptors in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Kinetics; Muscarine; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1993 |
Age-related changes in pulmonary muscarinic receptor binding properties.
Topics: Aging; Animals; Binding, Competitive; Guinea Pigs; Lung; Male; Muscarine; Parasympathomimetics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1993 |
3-Alpha-chloro-imperialine, a potent blocker of cholinergic presynaptic modulation of glutamatergic afferents in the rat neostriatum.
Topics: 4-Aminopyridine; Afferent Pathways; Animals; Atropine; Bicuculline; Carbachol; Cevanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gallamine Triethiodide; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Pirenzepine; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic; Synapses | 1998 |
Cholinergic modulation of neostriatal output: a functional antagonism between different types of muscarinic receptors.
Topics: Acetylcholine; Animals; Cadmium Chloride; Cesium; Chlorides; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Physostigmine; Pirenzepine; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Tetrodotoxin | 1999 |
[The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction].
Topics: Animals; Atropine; Brain; Female; Muscarine; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder; Urination | 2002 |