afdx 116 has been researched along with methoctramine in 26 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (methoctramine) | Trials (methoctramine) | Recent Studies (post-2010) (methoctramine) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 40 | 0 | 15 |
| 367 | 1 | 24 | 332 | 1 | 32 |
| Protein | Taxonomy | afdx 116 (IC50) | methoctramine (IC50) |
|---|---|---|---|
| Cholinesterase | Homo sapiens (human) | 0.9772 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.0407 | |
| Acetylcholinesterase | Homo sapiens (human) | 5.3703 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 0.138 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 0.138 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 0.9772 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 18 (69.23) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bonner, TI; Brann, MR; Buckley, CM; Buckley, NJ | 1 |
| Ehlert, FJ; Esqueda, EE; Gerstin, EH; Griffin, MT | 1 |
| Kovacs, I; Roeske, WR; Varga, EV; Waite, SL; Yamamura, HI | 1 |
| Casida, JE; Honda, H; Tomizawa, M | 1 |
| Egozi, Y; Koren, D; Sokolovsky, M | 1 |
| Anderson, DJ; Connolly, T; McKinney, M; Miller, JH; Vella-Rountree, L | 1 |
| Jiang, ZG; North, RA; Sugita, S; Uchimura, N | 1 |
| Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E; Tacke, R | 1 |
| Dowdall, MJ; Green, AC | 1 |
| Bast, A; Doelman, CJ; Nagtegaal, JE; Rodrigues de Miranda, JF; Sprong, RC | 1 |
| Bonner, TI; Brann, MR; Wess, J | 1 |
| Michel, AD; Whiting, RL | 1 |
| Bagetta, G; Constanti, A | 1 |
| Eglen, RM; Michel, AD; Whiting, RL | 1 |
| Anderson, D; el-Fakahany, EE; Forray, C; McKinney, M | 1 |
| Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J | 1 |
| Imaizumi, Y; Kawai, T; Masuda, Y; Ryang, S; Tanaka, M; Watanabe, M; Yamahara, NS | 1 |
| Boselli, C; Grana, E | 1 |
| Imaizumi, Y; Tanaka, M; Watanabe, M; Yamahara, NS | 1 |
| Hamstra, JJ; Roffel, AF; Santing, RE; ten Berge, RE; Zaagsma, J | 1 |
| Jakubík, J; Tucek, S | 1 |
| Davenport, TA; Fukumoto, Y; Gousse, A; Kamai, T; Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Aslan, AN; Oktay, S; Onat, F; Ozkutlu, U | 1 |
| Bukharaeva, EA; Magazanik, LG; Nikolsky, EE; Samigullin, D; Vyskocil, F | 1 |
| de Groat, WC; Ng, YK; Wu, HY | 1 |
| Arreola, JL; Chávez, J; Flores-Soto, E; Montaño, LM; Segura, P; Vargas, MH | 1 |
26 other study(ies) available for afdx 116 and methoctramine
| Article | Year |
|---|---|
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
Topics: Animals; Cell Line; Cloning, Molecular; Cricetinae; Humans; Kinetics; N-Methylscopolamine; Parasympatholytics; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Stimulation of cyclic AMP accumulation and phosphoinositide hydrolysis by M3 muscarinic receptors in the rat peripheral lung.
Topics: Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Hydrolysis; Lung; Male; Oxotremorine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1996 |
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
Topics: Amino Acid Sequence; Animals; Carbachol; Cloning, Molecular; Cyclic AMP; Humans; Mice; Molecular Sequence Data; Muscarinic Agonists; Muscarinic Antagonists; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Muscarinic; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity | 1998 |
Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists.
Topics: Animals; Brain; Drosophila; Houseflies; Insecta; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tritium | 2007 |
Muscarinic involvement in the regulation of gonadotropin-releasing hormone in the cyclic rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Diamines; Estrus; Female; Gonadotropin-Releasing Hormone; Median Eminence; Muscarinic Antagonists; Norepinephrine; Parasympatholytics; Pirenzepine; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Secretory Rate; Serotonin Antagonists | 1992 |
Pharmacological profiles for rat cortical M1 and M2 muscarinic receptors using selective antagonists: comparison with N1E-115 muscarinic receptors.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Diamines; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Phenethylamines; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Tumor Cells, Cultured | 1991 |
Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain; Corpus Striatum; Diamines; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Kinetics; Muscarine; Neurons; Nucleus Accumbens; Organ Specificity; Parasympatholytics; Pirenzepine; Quinoxalines; Rats; Receptors, Muscarinic; Synapses | 1991 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihypertensive Agents; Aorta, Abdominal; Arecoline; Atropine; Diamines; Endothelium, Vascular; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Norepinephrine; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic | 1991 |
Muscarinic autoreceptors of Torpedo electric organ are of the M1 subtype: evidence by radioligand binding using selective antagonists.
Topics: Animals; Diamines; Electric Organ; Muscarinic Antagonists; Myocardium; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Muscarinic; Torpedo | 1992 |
Prejunctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype.
Topics: Animals; Diamines; Electric Stimulation; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Male; Parasympathetic Nervous System; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1991 |
Chimeric m2/m3 muscarinic receptors: role of carboxyl terminal receptor domains in selectivity of ligand binding and coupling to phosphoinositide hydrolysis.
Topics: Animals; Cells, Cultured; Diamines; Hydrolysis; Ligands; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship | 1990 |
The binding of [3H]4-diphenylacetoxy-N-methylpiperidine methiodide to longitudinal ileal smooth muscle muscarinic receptors.
Topics: Animals; Binding, Competitive; Diamines; Gallamine Triethiodide; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic | 1990 |
Muscarinic suppression of the evoked N-wave by oxotremorine-M recorded in the guinea-pig olfactory cortex slice.
Topics: Action Potentials; Animals; Carbachol; Cerebral Cortex; Diamines; Electric Stimulation; Electroencephalography; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Olfactory Bulb; Oxotremorine; Parasympatholytics; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic | 1990 |
Characterization of the muscarinic receptor subtype mediating contractions of the guinea-pig uterus.
Topics: Animals; Diamines; Edetic Acid; Female; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic; Uterine Contraction | 1989 |
Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.
Topics: Animals; Brain Stem; Corpus Striatum; Cyclic AMP; Diamines; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic | 1989 |
Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.
Topics: Animals; Cattle; Dexetimide; Diamines; Gallamine Triethiodide; Heart; In Vitro Techniques; Membrane Proteins; Muscle, Smooth; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Trachea | 1989 |
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Animals; Arecoline; Bethanechol; Carbachol; Diamines; Dose-Response Relationship, Drug; Furans; Ganglia, Parasympathetic; Ganglionectomy; Iris; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 1995 |
Mode of antagonism of methoctramine, AF-DX 116 and hexahydrosiladifenidol in guinea-pig left atrium and ileum: comparison of Schild and resultant analysis.
Topics: Animals; Diamines; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Piperidines; Pirenzepine | 1995 |
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Diamines; Dose-Response Relationship, Drug; Furans; GTP-Binding Proteins; In Vitro Techniques; Iris; Male; Microinjections; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pertussis Toxin; Phentolamine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Virulence Factors, Bordetella | 1995 |
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity; Diamines; Disease Models, Animal; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart; Histamine; Hypersensitivity; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth; Neuromuscular Junction; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1995 |
Two populations of muscarinic binding sites in the chick heart distinguished by affinities for ligands and selective inactivation.
Topics: Alcuronium; Animals; Chickens; Choline; Cholinergic Agents; Diamines; Female; In Vitro Techniques; Ligands; Male; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives | 1994 |
Diabetes-induced alterations in the properties of muscarinic cholinergic receptors in rat vas deferens.
Topics: Animals; Atropine; Binding, Competitive; Diabetes Mellitus, Experimental; Diamines; Insulin; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Up-Regulation; Vas Deferens | 1994 |
Central muscarinic M2 cholinoceptors involved in cholinergic hypertension.
Topics: Animals; Blood Pressure; Diamines; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Muscarinic Antagonists; Oxotremorine; Physostigmine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1993 |
Cholinergic regulation of the evoked quantal release at frog neuromuscular junction.
Topics: Acetylcholine; Action Potentials; Animals; Arecoline; Carbachol; Cholinergic Agonists; Diamines; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Neural Conduction; Neuromuscular Junction; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Parasympatholytics; Pirenzepine; Rana ridibunda; Receptors, Muscarinic; Synaptic Transmission; Tubocurarine | 2004 |
Muscarinic regulation of neonatal rat bladder spontaneous contractions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcium Channel Agonists; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Diamines; Electric Stimulation; Muscle Contraction; Muscle Hypertonia; Muscle, Smooth; Parasympatholytics; Peptides; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder | 2006 |
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan | 2007 |