Page last updated: 2024-09-02

afdx 116 and methoctramine

afdx 116 has been researched along with methoctramine in 26 studies

Compound Research Comparison

Studies
(afdx 116)
Trials
(afdx 116)
Recent Studies (post-2010)
(afdx 116)
Studies
(methoctramine)
Trials
(methoctramine)
Recent Studies (post-2010) (methoctramine)
36712440015
367124332132

Protein Interaction Comparison

ProteinTaxonomyafdx 116 (IC50)methoctramine (IC50)
CholinesteraseHomo sapiens (human)0.9772
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.0407
AcetylcholinesteraseHomo sapiens (human)5.3703
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)0.138
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)0.138
Carboxylic ester hydrolase Rattus norvegicus (Norway rat)0.9772

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19904 (15.38)18.7374
1990's18 (69.23)18.2507
2000's4 (15.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bonner, TI; Brann, MR; Buckley, CM; Buckley, NJ1
Ehlert, FJ; Esqueda, EE; Gerstin, EH; Griffin, MT1
Kovacs, I; Roeske, WR; Varga, EV; Waite, SL; Yamamura, HI1
Casida, JE; Honda, H; Tomizawa, M1
Egozi, Y; Koren, D; Sokolovsky, M1
Anderson, DJ; Connolly, T; McKinney, M; Miller, JH; Vella-Rountree, L1
Jiang, ZG; North, RA; Sugita, S; Uchimura, N1
Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E; Tacke, R1
Dowdall, MJ; Green, AC1
Bast, A; Doelman, CJ; Nagtegaal, JE; Rodrigues de Miranda, JF; Sprong, RC1
Bonner, TI; Brann, MR; Wess, J1
Michel, AD; Whiting, RL1
Bagetta, G; Constanti, A1
Eglen, RM; Michel, AD; Whiting, RL1
Anderson, D; el-Fakahany, EE; Forray, C; McKinney, M1
Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J1
Imaizumi, Y; Kawai, T; Masuda, Y; Ryang, S; Tanaka, M; Watanabe, M; Yamahara, NS1
Boselli, C; Grana, E1
Imaizumi, Y; Tanaka, M; Watanabe, M; Yamahara, NS1
Hamstra, JJ; Roffel, AF; Santing, RE; ten Berge, RE; Zaagsma, J1
Jakubík, J; Tucek, S1
Davenport, TA; Fukumoto, Y; Gousse, A; Kamai, T; Latifpour, J; Weiss, RM; Yoshida, M1
Aslan, AN; Oktay, S; Onat, F; Ozkutlu, U1
Bukharaeva, EA; Magazanik, LG; Nikolsky, EE; Samigullin, D; Vyskocil, F1
de Groat, WC; Ng, YK; Wu, HY1
Arreola, JL; Chávez, J; Flores-Soto, E; Montaño, LM; Segura, P; Vargas, MH1

Other Studies

26 other study(ies) available for afdx 116 and methoctramine

ArticleYear
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
    Molecular pharmacology, 1989, Volume: 35, Issue:4

    Topics: Animals; Cell Line; Cloning, Molecular; Cricetinae; Humans; Kinetics; N-Methylscopolamine; Parasympatholytics; Rats; Receptors, Muscarinic; Scopolamine Derivatives

1989
Stimulation of cyclic AMP accumulation and phosphoinositide hydrolysis by M3 muscarinic receptors in the rat peripheral lung.
    Biochemical pharmacology, 1996, Aug-23, Volume: 52, Issue:4

    Topics: Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Hydrolysis; Lung; Male; Oxotremorine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic

1996
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: Amino Acid Sequence; Animals; Carbachol; Cloning, Molecular; Cyclic AMP; Humans; Mice; Molecular Sequence Data; Muscarinic Agonists; Muscarinic Antagonists; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Muscarinic; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity

1998
Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists.
    Journal of agricultural and food chemistry, 2007, Mar-21, Volume: 55, Issue:6

    Topics: Animals; Brain; Drosophila; Houseflies; Insecta; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tritium

2007
Muscarinic involvement in the regulation of gonadotropin-releasing hormone in the cyclic rat.
    Molecular and cellular endocrinology, 1992, Volume: 90, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Diamines; Estrus; Female; Gonadotropin-Releasing Hormone; Median Eminence; Muscarinic Antagonists; Norepinephrine; Parasympatholytics; Pirenzepine; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Secretory Rate; Serotonin Antagonists

1992
Pharmacological profiles for rat cortical M1 and M2 muscarinic receptors using selective antagonists: comparison with N1E-115 muscarinic receptors.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:3

    Topics: Animals; Cerebral Cortex; Cyclic AMP; Diamines; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Phenethylamines; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Tumor Cells, Cultured

1991
Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Mar-15, Volume: 88, Issue:6

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain; Corpus Striatum; Diamines; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Kinetics; Muscarine; Neurons; Nucleus Accumbens; Organ Specificity; Parasympatholytics; Pirenzepine; Quinoxalines; Rats; Receptors, Muscarinic; Synapses

1991
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihypertensive Agents; Aorta, Abdominal; Arecoline; Atropine; Diamines; Endothelium, Vascular; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Norepinephrine; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic

1991
Muscarinic autoreceptors of Torpedo electric organ are of the M1 subtype: evidence by radioligand binding using selective antagonists.
    Journal of neurochemistry, 1992, Volume: 58, Issue:2

    Topics: Animals; Diamines; Electric Organ; Muscarinic Antagonists; Myocardium; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Muscarinic; Torpedo

1992
Prejunctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype.
    European journal of pharmacology, 1991, Jan-25, Volume: 193, Issue:1

    Topics: Animals; Diamines; Electric Stimulation; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Male; Parasympathetic Nervous System; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea

1991
Chimeric m2/m3 muscarinic receptors: role of carboxyl terminal receptor domains in selectivity of ligand binding and coupling to phosphoinositide hydrolysis.
    Molecular pharmacology, 1990, Volume: 38, Issue:6

    Topics: Animals; Cells, Cultured; Diamines; Hydrolysis; Ligands; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship

1990
The binding of [3H]4-diphenylacetoxy-N-methylpiperidine methiodide to longitudinal ileal smooth muscle muscarinic receptors.
    European journal of pharmacology, 1990, Feb-06, Volume: 176, Issue:2

    Topics: Animals; Binding, Competitive; Diamines; Gallamine Triethiodide; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic

1990
Muscarinic suppression of the evoked N-wave by oxotremorine-M recorded in the guinea-pig olfactory cortex slice.
    European journal of pharmacology, 1990, Mar-13, Volume: 178, Issue:1

    Topics: Action Potentials; Animals; Carbachol; Cerebral Cortex; Diamines; Electric Stimulation; Electroencephalography; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Olfactory Bulb; Oxotremorine; Parasympatholytics; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic

1990
Characterization of the muscarinic receptor subtype mediating contractions of the guinea-pig uterus.
    British journal of pharmacology, 1989, Volume: 96, Issue:3

    Topics: Animals; Diamines; Edetic Acid; Female; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic; Uterine Contraction

1989
Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:2

    Topics: Animals; Brain Stem; Corpus Striatum; Cyclic AMP; Diamines; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic

1989
Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.
    European journal of pharmacology, 1989, Mar-07, Volume: 172, Issue:1

    Topics: Animals; Cattle; Dexetimide; Diamines; Gallamine Triethiodide; Heart; In Vitro Techniques; Membrane Proteins; Muscle, Smooth; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Trachea

1989
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Animals; Arecoline; Bethanechol; Carbachol; Diamines; Dose-Response Relationship, Drug; Furans; Ganglia, Parasympathetic; Ganglionectomy; Iris; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic

1995
Mode of antagonism of methoctramine, AF-DX 116 and hexahydrosiladifenidol in guinea-pig left atrium and ileum: comparison of Schild and resultant analysis.
    Journal of autonomic pharmacology, 1995, Volume: 15, Issue:2

    Topics: Animals; Diamines; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Piperidines; Pirenzepine

1995
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: Acetylcholine; Alkaloids; Animals; Atropine; Diamines; Dose-Response Relationship, Drug; Furans; GTP-Binding Proteins; In Vitro Techniques; Iris; Male; Microinjections; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pertussis Toxin; Phentolamine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Virulence Factors, Bordetella

1995
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity; Diamines; Disease Models, Animal; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart; Histamine; Hypersensitivity; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth; Neuromuscular Junction; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea

1995
Two populations of muscarinic binding sites in the chick heart distinguished by affinities for ligands and selective inactivation.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Alcuronium; Animals; Chickens; Choline; Cholinergic Agents; Diamines; Female; In Vitro Techniques; Ligands; Male; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives

1994
Diabetes-induced alterations in the properties of muscarinic cholinergic receptors in rat vas deferens.
    The Journal of urology, 1994, Volume: 152, Issue:3

    Topics: Animals; Atropine; Binding, Competitive; Diabetes Mellitus, Experimental; Diamines; Insulin; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Up-Regulation; Vas Deferens

1994
Central muscarinic M2 cholinoceptors involved in cholinergic hypertension.
    European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3

    Topics: Animals; Blood Pressure; Diamines; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Muscarinic Antagonists; Oxotremorine; Physostigmine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic

1993
Cholinergic regulation of the evoked quantal release at frog neuromuscular junction.
    The Journal of physiology, 2004, Oct-01, Volume: 560, Issue:Pt 1

    Topics: Acetylcholine; Action Potentials; Animals; Arecoline; Carbachol; Cholinergic Agonists; Diamines; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Neural Conduction; Neuromuscular Junction; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Parasympatholytics; Pirenzepine; Rana ridibunda; Receptors, Muscarinic; Synaptic Transmission; Tubocurarine

2004
Muscarinic regulation of neonatal rat bladder spontaneous contractions.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 291, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcium Channel Agonists; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Diamines; Electric Stimulation; Muscle Contraction; Muscle Hypertonia; Muscle, Smooth; Parasympatholytics; Peptides; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder

2006
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:4

    Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan

2007