Compounds > afdx 116

Page last updated: 2024-09-02

afdx 116 and methacholine chloride

afdx 116 has been researched along with methacholine chloride in 12 studies

Compound Research Comparison

Studies (afdx 116)	Trials (afdx 116)	Recent Studies (post-2010) (afdx 116)	Studies (methacholine chloride)	Trials (methacholine chloride)	Recent Studies (post-2010) (methacholine chloride)
367	1	24	5,443	835	824

Protein Interaction Comparison

Protein	Taxonomy	afdx 116 (IC50)	methacholine chloride (IC50)
galanin receptor type 3	Homo sapiens (human)		7.365

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (16.67)	18.7374
1990's	9 (75.00)	18.2507
2000's	1 (8.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hendriks, MG; Pfaffendorf, M; Van Zwieten, PA	1
Bloom, JW; Halonen, M; Mahesh, VK; Nunan, LM; Palmer, JD; Yamamura, HI	1
Fernandes, LB; Fryer, AD; Hirshman, CA	1
Nishimura, S; Sorimachi, M; Yamagami, K	1
Blaxall, HS; Cunningham, J; Gardier, RW; Killian, LN	1
Kobayashi, H; Mochida, S	1
Ashe, JH; Olito, AC; Yarosh, CA	1
Imaizumi, Y; Kawai, T; Masuda, Y; Ryang, S; Tanaka, M; Watanabe, M; Yamahara, NS	1
Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J	1
Bruning, TA; Chang, PC; Hendriks, MG; Pfaffendorf, M; van Zwieten, PA; Vermeij, P	1
Bruning, TA; Chang, PC; Hendriks, MG; Kuypers, EA; van Zwieten, PA	1
Fushimi, T; Masuda, T; Saitoh, H; Shimura, S; Shirato, K	1

Trials

1 trial(s) available for afdx 116 and methacholine chloride

Article	Year
In vivo characterization of muscarinic receptor subtypes that mediate vasodilatation in patients with essential hypertension. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 26, Issue:1 Topics: Atropine; Forearm; Humans; Hypertension; Male; Methacholine Chloride; Middle Aged; Nitroprusside; Parasympatholytics; Pirenzepine; Plethysmography; Receptors, Muscarinic; Vasodilation	1995

Other Studies

11 other study(ies) available for afdx 116 and methacholine chloride

Article	Year
Characterization of the muscarinic receptor subtype mediating vasodilation in the rat perfused mesenteric vascular bed preparation. Journal of autonomic pharmacology, 1992, Volume: 12, Issue:6 Topics: Animals; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Methacholine Chloride; Parasympatholytics; Perfusion; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Vasodilation	1992
A minority of muscarinic receptors mediate rabbit tracheal smooth muscle contraction. American journal of respiratory cell and molecular biology, 1992, Volume: 6, Issue:3 Topics: Animals; Atropine; Female; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myocardium; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Radioligand Assay; Receptors, Muscarinic; Trachea	1992
M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1 Topics: Animals; Dogs; Drug Interactions; Isoproterenol; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea	1992
Internal Ca2+ mobilization by muscarinic stimulation increases secretion from adrenal chromaffin cells only in the presence of Ca2+ influx. Journal of neurochemistry, 1991, Volume: 57, Issue:5 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Atropine; Calcium; Catecholamines; Cats; Cattle; Cytosol; Gallopamil; Kinetics; Methacholine Chloride; Muscarine; Nicotine; Parasympatholytics; Pilocarpine; Pirenzepine; Receptors, Muscarinic	1991
Reserpine-induced post-receptor reduction in muscarinic-mediated airway smooth muscle contraction. Life sciences, 1991, Volume: 48, Issue:18 Topics: Animals; Binding, Competitive; Bronchi; Humans; Lung; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Organ Specificity; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Reserpine; Trachea	1991
A novel muscarinic receptor antagonist AF-DX 116 differentially blocks slow inhibitory and slow excitatory postsynaptic potentials in the rabbit sympathetic ganglia. Life sciences, 1988, Volume: 42, Issue:22 Topics: Action Potentials; Animals; Bethanechol; Bethanechol Compounds; Evoked Potentials; Ganglia, Sympathetic; Male; Methacholine Chloride; Methacholine Compounds; Pirenzepine; Rabbits; Receptors, Muscarinic; Synapses	1988
AF-DX 116: a selective antagonist of the slow inhibitory postsynaptic potential and methacholine-induced hyperpolarization in superior cervical ganglion of the rabbit. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:2 Topics: Animals; Ganglia, Sympathetic; In Vitro Techniques; Membrane Potentials; Methacholine Chloride; Methacholine Compounds; Pirenzepine; Rabbits; Receptors, Muscarinic; Synapses	1988
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle. British journal of pharmacology, 1995, Volume: 114, Issue:4 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Animals; Arecoline; Bethanechol; Carbachol; Diamines; Dose-Response Relationship, Drug; Furans; Ganglia, Parasympathetic; Ganglionectomy; Iris; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic	1995
No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea. British journal of pharmacology, 1995, Volume: 115, Issue:4 Topics: Animals; Bronchoconstrictor Agents; Cattle; Dose-Response Relationship, Drug; Gallamine Triethiodide; Histamine; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicotinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Adrenergic, beta; Receptors, Muscarinic; Trachea	1995
In vivo characterization of vasodilating muscarinic-receptor subtypes in humans. Circulation research, 1994, Volume: 74, Issue:5 Topics: Acetylcholine; Adult; Atropine; Clinical Protocols; Forearm; Humans; Male; Methacholine Chloride; Pirenzepine; Receptors, Muscarinic; Vasodilation	1994
Secretion and gene expression of secretory leukocyte protease inhibitor by human airway submucosal glands. American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Atropine; Bronchi; Dexamethasone; Dose-Response Relationship, Drug; Exocrine Glands; Female; Gene Expression; Glucocorticoids; Humans; Leukocyte Elastase; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Proteinase Inhibitory Proteins, Secretory; Proteins; Respiratory Mucosa; RNA, Messenger; Secretory Leukocyte Peptidase Inhibitor; Trachea	2001