Page last updated: 2024-09-02

afdx 116 and isoproterenol

afdx 116 has been researched along with isoproterenol in 10 studies

Compound Research Comparison

Studies
(afdx 116)
Trials
(afdx 116)
Recent Studies (post-2010)
(afdx 116)
Studies
(isoproterenol)
Trials
(isoproterenol)
Recent Studies (post-2010) (isoproterenol)
36712430,7808032,640

Protein Interaction Comparison

ProteinTaxonomyafdx 116 (IC50)isoproterenol (IC50)
Beta-2 adrenergic receptorHomo sapiens (human)0.246
Beta-1 adrenergic receptorHomo sapiens (human)0.333
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.2125
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)1.77
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.2125
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.2125
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.6667

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (90.00)18.2507
2000's1 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fernandes, LB; Fryer, AD; Hirshman, CA1
Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J1
Ehlert, FJ; Thomas, EA2
Arana, R; Bacman, S; Borda, E; Camusso, JJ; Hubscher, O; Sterin-Borda, L1
Akaishi, Y; Hattori, Y; Kanno, M; Kitabatake, A; Sakuma, I1
Ehlert, FJ; Sawyer, GW1
Mitchelson, F; Shen, A1
Ehlert, FJ; Ostrom, RS1
Ehlert, FJ; Figueroa, KW; Griffin, MT; Liller, S1

Other Studies

10 other study(ies) available for afdx 116 and isoproterenol

ArticleYear
M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1

    Topics: Animals; Dogs; Drug Interactions; Isoproterenol; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea

1992
No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea.
    British journal of pharmacology, 1995, Volume: 115, Issue:4

    Topics: Animals; Bronchoconstrictor Agents; Cattle; Dose-Response Relationship, Drug; Gallamine Triethiodide; Histamine; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicotinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Adrenergic, beta; Receptors, Muscarinic; Trachea

1995
Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Cyclic AMP; Guanosine Triphosphate; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Signal Transduction; Virulence Factors, Bordetella

1994
Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus.
    Biochemical pharmacology, 1996, Mar-22, Volume: 51, Issue:6

    Topics: Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Esophagus; Gastric Fundus; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serotonin; Trachea; Virulence Factors, Bordetella

1996
Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome.
    Clinical and experimental immunology, 1996, Volume: 104, Issue:3

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Animals; Antibodies, Blocking; Atropine; Carbachol; Carbamates; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin G; Isoproterenol; Muscarinic Antagonists; Parasympatholytics; Parotid Gland; Phenylcarbamates; Phosphatidylinositols; Piperidines; Pirenzepine; Protease Inhibitors; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Sjogren's Syndrome

1996
Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:2

    Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atropine; Cell Membrane; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanylyl Imidodiphosphate; Heart Ventricles; Isoproterenol; Male; Muscarinic Antagonists; Pertussis Toxin; Pirenzepine; Propanolamines; Rabbits; Receptor, Muscarinic M2; Receptors, Adrenergic, beta; Receptors, Muscarinic; Virulence Factors, Bordetella

1997
Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:1

    Topics: Animals; Colforsin; Colon; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella

1998
Muscarinic M2 receptor-mediated contraction in the guinea pig Taenia caeci: possible involvement of protein kinase C.
    Biochemical pharmacology, 1998, Dec-01, Volume: 56, Issue:11

    Topics: Animals; Cecum; Colforsin; Diphenylacetic Acids; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Kinetics; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Piperidines; Pirenzepine; Protein Kinase C; Receptor, Muscarinic M2; Receptors, Muscarinic; Second Messenger Systems

1998
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: Animals; Colforsin; Diphenylacetic Acids; Guinea Pigs; Histamine; Ileum; Isoproterenol; Muscle Relaxation; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea; Virulence Factors, Bordetella

1999
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Algorithms; Animals; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Humans; Isoproterenol; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidines; Receptor, Muscarinic M2; Signal Transduction; Transfection

2007