afdx 116 has been researched along with dexetimide in 4 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (dexetimide) | Trials (dexetimide) | Recent Studies (post-2010) (dexetimide) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 117 | 4 | 4 |
| Protein | Taxonomy | afdx 116 (IC50) | dexetimide (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | 0.0033 | |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | 0.0033 | |
| Muscarinic acetylcholine receptor M5 | Mus musculus (house mouse) | 0.0033 | |
| Muscarinic acetylcholine receptor M3 | Mus musculus (house mouse) | 0.0033 | |
| Muscarinic acetylcholine receptor M2 | Mus musculus (house mouse) | 0.0033 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kovacs, I; Roeske, WR; Varga, EV; Waite, SL; Yamamura, HI | 1 |
| Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J | 1 |
| de Zeeuw, RA; in't Hout, WG; Roffel, AF; Zaagsma, J | 1 |
| Christopoulos, A; Lanzafame, A; Mitchelson, F | 1 |
4 other study(ies) available for afdx 116 and dexetimide
| Article | Year |
|---|---|
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
Topics: Amino Acid Sequence; Animals; Carbachol; Cloning, Molecular; Cyclic AMP; Humans; Mice; Molecular Sequence Data; Muscarinic Agonists; Muscarinic Antagonists; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Muscarinic; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity | 1998 |
Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.
Topics: Animals; Cattle; Dexetimide; Diamines; Gallamine Triethiodide; Heart; In Vitro Techniques; Membrane Proteins; Muscle, Smooth; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Trachea | 1989 |
The M2 selective antagonist AF-DX 116 shows high affinity for muscarine receptors in bovine tracheal membranes.
Topics: Animals; Binding, Competitive; Cattle; Dexetimide; In Vitro Techniques; Membrane Proteins; Muscle, Smooth; Myocardium; Pirenzepine; Receptors, Muscarinic; Trachea | 1987 |
The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria.
Topics: Acetylcholine; Allosteric Regulation; Animals; Atropine; Carbachol; Cardiotonic Agents; Dexetimide; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Nicotinic Antagonists; Parasympatholytics; Phthalimides; Pirenzepine; Quaternary Ammonium Compounds; Radioligand Assay; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |