afdx 116 has been researched along with clonidine in 3 studies
| Studies (afdx 116) | Trials (afdx 116) | Recent Studies (post-2010) (afdx 116) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 367 | 1 | 24 | 13,692 | 2,044 | 1,394 |
| Protein | Taxonomy | afdx 116 (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiba, S; Furukawa, Y; Nakane, T | 1 |
| Giachetti, A; Micheletti, R; Montagna, E | 1 |
| Bouaziz, H; Detweiler, DJ; Eisenach, JC; Li, P; Lothe, A; Tong, C; Yoon, Y | 1 |
3 other study(ies) available for afdx 116 and clonidine
| Article | Year |
|---|---|
Anti-muscarinic effect of alinidine on acetylcholine-induced vasodilation in isolated and perfused dog coronary arteries.
Topics: Acetylcholine; Animals; Carbachol; Clonidine; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Parasympatholytics; Piperidines; Pirenzepine; Vasodilation | 1991 |
Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist.
Topics: Animals; Atrial Function; Benzodiazepinones; Binding, Competitive; Cats; Clonidine; Dogs; Female; Guinea Pigs; Heart; Heart Atria; Heart Rate; Ileum; In Vitro Techniques; Kinetics; Male; Mice; Muscle, Smooth; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stomach; Sympatholytics; Urinary Bladder | 1986 |
Spinal cholinergic alpha-2 adrenergic interactions in analgesia and hemodynamic control: role of muscarinic receptor subtypes and nitric oxide.
Topics: Analgesia; Animals; Clonidine; Female; Hemodynamics; Neostigmine; Nitric Oxide; Pirenzepine; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Sheep; Spinal Cord | 1994 |