Page last updated: 2024-09-02

afdx 116 and (4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride

afdx 116 has been researched along with (4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride in 25 studies

Compound Research Comparison

Studies (afdx 116)	Trials (afdx 116)	Recent Studies (post-2010) (afdx 116)	Studies ((4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride)	Trials ((4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride)	Recent Studies (post-2010) ((4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride)
367	1	24	285	0	17

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (24.00)	18.7374
1990's	17 (68.00)	18.2507
2000's	1 (4.00)	29.6817
2010's	1 (4.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bartolini, A; Fantetti, L; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P	1
Gies, JP; Haddad, EB; Landry, Y	1
Bindslev, N; Winding, B	1
Daniel, EE; Janssen, LJ	1
Choo, LK; Mitchelson, F	1
Kimura, T; Mukaiyama, O; Satoh, S; Takeuchi, A	1
Matsumoto, K; Pappano, AJ	1
Donoff, B; Lad, R; Rangachari, PK	1
Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E; Tacke, R	1
Boddeke, HW	1
Alonso, MJ; Arribas, S; Balfagón, G; Marín, J; Salaices, M	1
Kobayashi, H; Mochida, S	1
Goode, TL; Mathiasen, JR; Raffa, RB; Vaught, JL	1
Jaiswal, N; Malik, KU	1
Duckles, SP	1
Galvan, M	1
Murugaian, J; Sapru, H; Sundaram, K; Watson, M	1
Chiba, S; Nakane, T; Ren, LM	1
Bai, D; Sattelle, DB	1
Imaizumi, Y; Kawai, T; Masuda, Y; Ryang, S; Tanaka, M; Watanabe, M; Yamahara, NS	1
Baird, AW; Farrell, CB; O'Boyle, KM; O'Malley, KE	1
Marks, GA; Roffwarg, HP	1
Islam, MA; Kimura, I; Nojima, H	1
Ehlert, FJ; Figueroa, KW; Griffin, MT; Liller, S	1
Anderson, RW; Strowbridge, BW	1

Other Studies

25 other study(ies) available for afdx 116 and (4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride

Article	Year
Role of muscarinic receptor subtypes in central antinociception. British journal of pharmacology, 1992, Volume: 105, Issue:1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesia; Animals; Male; Mice; Pain Measurement; Pirenzepine; Quinuclidines; Receptors, Muscarinic; Thiophenes	1992
Sialic acid residues as catalysts for M2-muscarinic agonist-receptor interactions. Molecular pharmacology, 1990, Volume: 37, Issue:5 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cell Membrane; Kinetics; Male; Myocardium; Neuraminidase; Oxotremorine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Sialic Acids	1990
Characterization of a muscarinic receptor controlling Cl- secretion in hen trachea. The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bumetanide; Calcium Channels; Chickens; Chlorides; Dicyclomine; Female; In Vitro Techniques; Ion Channels; Kinetics; Mucous Membrane; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea	1990
Pre- and postjunctional muscarinic receptors in canine bronchi. The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bethanechol Compounds; Bronchi; Carbachol; Dogs; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Pirenzepine; Receptors, Muscarinic	1990
Selective inhibition of responses to carbachol and McN-A-343 in the rabbit vas deferens. Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:9 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bis-Trimethylammonium Compounds; Carbachol; Cocaine; Electric Stimulation; In Vitro Techniques; Isoindoles; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pancuronium; Pirenzepine; Rabbits; Vas Deferens	1990
Effects of pirenzepine and AF-DX 116 on ganglionic transmission in the cardiac sympathetic nerves of the dog: interaction of M1 and M2 receptors with nicotinic receptors. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:2 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Blood Pressure; Dogs; Electric Stimulation; Female; Ganglia, Sympathetic; Heart Rate; Hexamethonium; Hexamethonium Compounds; Male; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Sympathetic Nervous System; Synaptic Transmission	1991
Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors. Molecular pharmacology, 1991, Volume: 39, Issue:3 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Cells, Cultured; Electric Conductivity; GTP-Binding Proteins; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Pertussis Toxin; Pirenzepine; Receptors, Muscarinic; Sodium; Virulence Factors, Bordetella	1991
Functional subtyping of muscarinic receptors on canine esophageal mucosa. The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Amiloride; Animals; Atropine; Carbachol; Chlorides; Dogs; Electric Conductivity; Esophagus; Female; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Mucous Membrane; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Sodium	1991
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihypertensive Agents; Aorta, Abdominal; Arecoline; Atropine; Diamines; Endothelium, Vascular; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Norepinephrine; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic	1991
Different effects of muscarinic agonists in rat superior cervical ganglion and hippocampal slices. European journal of pharmacology, 1991, Aug-29, Volume: 201, Issue:2-3 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Ganglia, Sympathetic; Hippocampus; In Vitro Techniques; Male; Oxotremorine; Parasympathomimetics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains	1991
Presynaptic M2-muscarinic receptors on noradrenergic nerve endings and endothelium-derived M3 receptors in cat cerebral arteries. Brain research, 1991, Dec-13, Volume: 567, Issue:1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Carbachol; Cats; Cerebral Arteries; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasodilation	1991
Activation of M2 muscarinic receptors causes an alteration of action potentials by modulation of Ca entry in isolated sympathetic neurons of rabbits. Neuroscience letters, 1986, Dec-12, Volume: 72, Issue:2 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Action Potentials; Animals; Calcium; Cells, Cultured; Ganglia, Sympathetic; Male; Muscarine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic	1986
Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M1 type receptors. Life sciences, 1987, Oct-12, Volume: 41, Issue:15 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Injections, Spinal; Male; Mice; Parasympathomimetics; Pilocarpine; Pirenzepine; Receptors, Muscarinic; Spinal Cord; Stereotyped Behavior	1987
Prostaglandin synthesis elicited by cholinergic stimuli is mediated by activation of M2 muscarinic receptors in rabbit heart. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Arecoline; Heart; Heart Rate; Hexamethonium Compounds; Indomethacin; Male; Myocardium; Phentolamine; Pirenzepine; Propranolol; Prostaglandins; Rabbits; Receptors, Muscarinic	1988
Vascular muscarinic receptors: pharmacological characterization in the bovine coronary artery. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Calcimycin; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Muscle Contraction; Muscle, Smooth, Vascular; Pirenzepine; Rabbits; Receptors, Muscarinic	1988
Modulation of synaptic transmission in autonomic ganglia mediated via the activation of postganglionic muscarinic M1 receptors. Pharmacology, 1988, Volume: 37 Suppl 1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Ganglia, Autonomic; Ganglia, Sympathetic; In Vitro Techniques; Muscarine; Pirenzepine; Rabbits; Rats; Receptors, Muscarinic; Synapses; Synaptic Transmission	1988
M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii. Brain research, 1989, Jan-16, Volume: 477, Issue:1-2 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Blood Pressure; Glutamates; Heart Rate; Male; Medulla Oblongata; Microinjections; Physostigmine; Pirenzepine; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Reference Values	1989
Muscarinic receptor subtypes mediating vasodilation and vasoconstriction in isolated, perfused simian coronary arteries. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:6 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Female; In Vitro Techniques; Macaca; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth, Vascular; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasoconstriction; Vasodilation	1993
Muscarinic acetylcholine receptors on an identified motor neurone in the cockroach, Periplaneta americana. Neuroscience letters, 1994, Jul-04, Volume: 175, Issue:1-2 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Atropine; Dose-Response Relationship, Drug; Evoked Potentials; Ganglia, Invertebrate; In Vitro Techniques; Male; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Periplaneta; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine; Vertebrates	1994
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle. British journal of pharmacology, 1995, Volume: 114, Issue:4 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Animals; Arecoline; Bethanechol; Carbachol; Diamines; Dose-Response Relationship, Drug; Furans; Ganglia, Parasympathetic; Ganglionectomy; Iris; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic	1995
Cholinergic activation of Cl- secretion in rat colonic epithelia. European journal of pharmacology, 1995, Feb-24, Volume: 275, Issue:1 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Binding, Competitive; Chlorides; Cholinergic Agonists; Cholinergic Antagonists; Colon; Dose-Response Relationship, Drug; Epithelium; Hexamethonium; In Vitro Techniques; Ion Transport; Male; Muscarinic Agonists; Parasympatholytics; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Wistar	1995
Cholinergic responsiveness of neurons in the ventroposterior thalamus of the anesthetized rat. Neuroscience, 1993, Volume: 54, Issue:2 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Anesthesia, General; Animals; Carbachol; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Hypothalamus, Posterior; Iontophoresis; Male; Neurons; Parasympatholytics; Pirenzepine; Rats; Stereotaxic Techniques	1993
Muscarinic M1 receptor activation reduces maximum upstroke velocity of action potential in mouse right atria. European journal of pharmacology, 1998, Apr-10, Volume: 346, Issue:2-3 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Action Potentials; Animals; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Mice; Microelectrodes; Muscarinic Agonists; Oxotremorine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic	1998
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Algorithms; Animals; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Humans; Isoproterenol; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidines; Receptor, Muscarinic M2; Signal Transduction; Transfection	2007
Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials. Learning & memory (Cold Spring Harbor, N.Y.), 2014, Apr-15, Volume: 21, Issue:5 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Animals, Newborn; Carbachol; Cholinergic Agonists; Electric Stimulation; Excitatory Amino Acid Agents; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Muscarinic Agonists; Muscarinic Antagonists; Nerve Fibers; Pirenzepine; Pyramidal Cells; Rats; Rats, Sprague-Dawley	2014