adrenomedullin and phenylhydrazine

The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

Topics: Adrenomedullin; Agaricus; Animals; Antioxidants; Complex Mixtures; Disease Models, Animal; Jaundice, Neonatal; NF-kappa B; Phenylhydrazines; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides