adrenomedullin and 1-1-diethyl-2-hydroxy-2-nitrosohydrazine

adrenomedullin has been researched along with 1-1-diethyl-2-hydroxy-2-nitrosohydrazine* in 2 studies

Other Studies

2 other study(ies) available for adrenomedullin and 1-1-diethyl-2-hydroxy-2-nitrosohydrazine

Article	Year
Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat. Life sciences, 1997, Volume: 60, Issue:16 The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1. In the present study responses to intravenous administration of nociceptin were investigated in the systemic vascular bed of the rat. Nociceptin induced dose-related decreases in systemic arterial pressure when injected in doses of 1-30 nmol/kg i.v. In terms of relative vasodepressor activity, nociceptin was approximately 10-fold more potent than the nitric oxide donor, DEA/NO, and 10-fold less potent than adrenomedullin. The duration of the vasodepressor response to nociceptin was shorter than adrenomedullin but longer than DEA/NO. These results show that nociceptin has significant vasodepressor activity in the rat. Topics: Adrenomedullin; Amino Acid Sequence; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Hydrazines; Hypotension; Ligands; Male; Molecular Sequence Data; Nitrogen Oxides; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Vasoconstrictor Agents; Vasodilator Agents	1997
Nociceptin, an endogenous ligand for the ORL1 receptor, has vasodilator activity in the hindquarters vascular bed of the rat. Peptides, 1997, Volume: 18, Issue:6 The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the G-protein coupled, opioid-like receptor ORL1. In the present study, responses to intra-arterial injections of nociceptin were investigated in the hindquarters vascular bed of the rat. Under constant-flow conditions nociceptin induced dose-dependent decreases in hindquarters perfusion pressure when injected in doses of 1-30 nmol into the hindquarters perfusion circuit. The decreases in hindquarters perfusion pressure were rapid in onset and pressure returned to control values over a 3-6 min period. In terms of relative vasodilator activity, nociceptin was approximately equipotent to the nitric oxide donor, DEA/NO, and 30-fold less potent than adrenomedullin. These data demonstrate that nociceptin has significant vasodilator activity in the hindquarters vascular bed of the rat. Topics: Adrenomedullin; Animals; Female; Hindlimb; Hydrazines; Injections, Intra-Arterial; Ligands; Male; Nitrogen Oxides; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Vasoactive Intestinal Peptide; Vasodilator Agents	1997

Article

Year

Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat.

Life sciences, 1997, Volume: 60, Issue:16

The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1. In the present study responses to intravenous administration of nociceptin were investigated in the systemic vascular bed of the rat. Nociceptin induced dose-related decreases in systemic arterial pressure when injected in doses of 1-30 nmol/kg i.v. In terms of relative vasodepressor activity, nociceptin was approximately 10-fold more potent than the nitric oxide donor, DEA/NO, and 10-fold less potent than adrenomedullin. The duration of the vasodepressor response to nociceptin was shorter than adrenomedullin but longer than DEA/NO. These results show that nociceptin has significant vasodepressor activity in the rat.

Topics: Adrenomedullin; Amino Acid Sequence; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Hydrazines; Hypotension; Ligands; Male; Molecular Sequence Data; Nitrogen Oxides; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Vasoconstrictor Agents; Vasodilator Agents

1997

Nociceptin, an endogenous ligand for the ORL1 receptor, has vasodilator activity in the hindquarters vascular bed of the rat.

Peptides, 1997, Volume: 18, Issue:6

The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the G-protein coupled, opioid-like receptor ORL1. In the present study, responses to intra-arterial injections of nociceptin were investigated in the hindquarters vascular bed of the rat. Under constant-flow conditions nociceptin induced dose-dependent decreases in hindquarters perfusion pressure when injected in doses of 1-30 nmol into the hindquarters perfusion circuit. The decreases in hindquarters perfusion pressure were rapid in onset and pressure returned to control values over a 3-6 min period. In terms of relative vasodilator activity, nociceptin was approximately equipotent to the nitric oxide donor, DEA/NO, and 30-fold less potent than adrenomedullin. These data demonstrate that nociceptin has significant vasodilator activity in the hindquarters vascular bed of the rat.

Topics: Adrenomedullin; Animals; Female; Hindlimb; Hydrazines; Injections, Intra-Arterial; Ligands; Male; Nitrogen Oxides; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Vasoactive Intestinal Peptide; Vasodilator Agents

1997